Libman-Sacks Endocarditis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Libman-Sacks Endocarditis

MalaCards integrated aliases for Libman-Sacks Endocarditis:

Name: Libman-Sacks Endocarditis ¹¹ ¹⁴ ⁷⁵

Libmann-Sachs, Endocarditis in Systemic Lupus Erythematosus ¹¹

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0080740

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Summaries for Libman-Sacks Endocarditis

Disease Ontology: ¹¹ An endocarditis that is characterized by Libman-Sacks vegetations, is common in patients with systemic lupus erythematosus and is commonly complicated with embolic cerebrovascular disease.

MalaCards based summary: Libman-Sacks Endocarditis, also known as libmann-sachs, endocarditis in systemic lupus erythematosus, is related to endocarditis and mitral valve insufficiency. An important gene associated with Libman-Sacks Endocarditis is CFHR2 (Complement Factor H Related 2), and among its related pathways/superpathways are Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) and Complement cascade. Affiliated tissues include heart, lung and brain.

Wikipedia: ⁷⁵ Libman-Sacks endocarditis is a form of non-bacterial endocarditis that is seen in association with... more...

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Related Diseases for Libman-Sacks Endocarditis

Diseases related to Libman-Sacks Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)

#	Related Disease	Score	Top Affiliating Genes
1	endocarditis	31.9	F2 CRP APOH
2	mitral valve insufficiency	31.4	F2 CRP
3	aortic valve insufficiency	31.2	F2 CRP
4	antiphospholipid syndrome	31.1	F2 CRP C3 APOH
5	infective endocarditis	31.1	PRTN3 F2 CRP CFHR2
6	heart valve disease	31.0	F2 CRP APOH
7	intracranial embolism	31.0	F2 CRP
8	mitral valve stenosis	31.0	F2 CRP
9	tricuspid valve insufficiency	30.9	F2 CRP
10	nonbacterial thrombotic endocarditis	30.8	F2 CRP APOH
11	cerebrovascular disease	30.7	F2 CRP APOH
12	stroke, ischemic	30.6	PRTN3 F2 CRP APOH
13	retinal artery occlusion	30.5	F2 CRP APOH
14	facial paralysis	30.5	PRTN3 CRP
15	cellulitis	30.5	F2 CRP
16	patent foramen ovale	30.5	F2 CRP APOH
17	polyarteritis nodosa	30.4	PRTN3 CRP APOH
18	transient cerebral ischemia	30.3	F2 CRP APOH
19	pulmonary embolism	30.3	F2 CRP APOH
20	mitral valve disease	30.3	F2 CRP
21	central retinal artery occlusion	30.2	PRTN3 F2 CRP
22	lupus erythematosus	30.2	TRIM21 SNRNP70 RO60 C3 APOH
23	purpura	30.0	F2 CRP C3 APOH
24	autoimmune disease	30.0	TRIM21 RO60 PRTN3 CRP APOH
25	hypersensitivity reaction type iii disease	29.9	PRTN3 CRP CFHR2 C3
26	thrombocytopenia	29.6	TRIM21 F2 CRP C3 APOH
27	collagen disease	29.4	TRIM21 SNRNP70 PRTN3 CRP CFHR2 APOH
28	systemic lupus erythematosus	29.0	TRIM21 SNRNP70 RO60 PRTN3 F2 CRP
29	systemic lupus erythematosus 1	10.9
30	catastrophic antiphospholipid syndrome	10.5
31	systemic autoimmune disease	10.4
32	diffuse alveolar hemorrhage	10.4
33	cerebral artery occlusion	10.4
34	vitamin k deficiency bleeding	10.4
35	pulmonary edema	10.4
36	pyelonephritis	10.4
37	vascular disease	10.4
38	thrombophilia	10.4
39	cryopyrin-associated periodic syndrome	10.4
40	skeletal tuberculosis	10.2	CRP CFHR2
41	bicipital tenosynovitis	10.2	PRTN3 CRP
42	tenosynovitis	10.2	PRTN3 CRP
43	orbital granuloma	10.2	PRTN3 CRP
44	arteritic anterior ischemic optic neuropathy	10.2	PRTN3 CRP
45	sclerosing keratitis	10.2	PRTN3 CRP
46	anterior scleritis	10.2	PRTN3 CRP
47	scleritis	10.2	PRTN3 CRP
48	lateral medullary syndrome	10.2	PRTN3 CRP
49	multiple cranial nerve palsy	10.2	PRTN3 CRP
50	posterior scleritis	10.2	PRTN3 CRP

Graphical network of the top 20 diseases related to Libman-Sacks Endocarditis:

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Symptoms & Phenotypes for Libman-Sacks Endocarditis

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Drugs & Therapeutics for Libman-Sacks Endocarditis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus	Completed	NCT00858884

Search NIH Clinical Center for Libman-Sacks Endocarditis

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Genetic Tests for Libman-Sacks Endocarditis

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Anatomical Context for Libman-Sacks Endocarditis

Organs/tissues related to Libman-Sacks Endocarditis:

MalaCards : Heart, Lung, Brain

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Publications for Libman-Sacks Endocarditis

Articles related to Libman-Sacks Endocarditis:

(show top 50) (show all 229)

#	Title	Authors	PMID	Year
1	Severe aortic regurgitation from aortic valve perforation in Libman-Sacks endocarditis: Incremental value of 3D TEE. ⁶²	Adil A...Ammar KA	36354009	2022
2	A Rare Case of Tricuspid Valve Libman-Sacks Endocarditis in a Pregnant Woman with Primary Antiphospholipid Syndrome. ⁶²	Migliorini S...Sarno L	36233742	2022
3	Libman-Sacks Endocarditis and Infective Endocarditis Vegetations Coexisting in a Patient With Antiphospholipid Syndrome. ⁶²	Chen H...Chen X	35922911	2022
4	[Delayed white matter lesion after mechanical thrombectomy for middle cerebral artery occlusion with Libman-Sacks endocarditis]. ⁶²	Kutsuna A...Kimura K	36031377	2022
5	Aortic valve Libman‑Sacks endocarditis mimicking papillary fibroelastoma: therapeutic possibilities. ⁶²	Czub P...Budnik M	35699944	2022
6	All Endocarditis Is Not Infective: Libman-Sacks Endocarditis. ⁶²	Al Riyami H...Abdwani R	35936150	2022
7	[Aortic Valve Replacement for Libman-Sacks Endocarditis:Report of a Case]. ⁶²	Okada S...Oi A	35618691	2022
8	Severe Libman-Sacks endocarditis complicating antiphospholipid syndrome: a retrospective analysis of 23 operated cases. ⁶²	Chalvon Bourse N...Orquevaux P	35686908	2022
9	Subacute infective endocarditis caused by Bacillus cereus in a patient with Systemic Lupus Erythematosus. ⁶²	Ribeiro RL...Martins IS	35544639	2022
10	Case report: Mitral valve replacement for Libman-Sacks endocarditis and cerebral embolism of primary antiphospholipid syndrome. ⁶²	Liang H...Chen X	36061548	2022
11	Mitral valve replacement due to Libman-Sacks endocarditis: lower limb cellulitis as a red herring. ⁶²	Sexton G...Doddakula K	35058285	2022
12	[Superinfection of Libman-Sacks endocarditis in a lupus patient: a case report]. ⁶²	Tchibinda NDT...Fellat R	36405651	2022
13	Catastrophic anti-phospholipid syndrome with Libman-Sacks endocarditis following eltrombopag therapy for immune thrombocytopenic purpura: A case report. ⁶²	Dichtwald S...Ifrach N	34923861	2021
14	Unveiling Uncommon Manifestations in a Pediatric Patient With Systemic Lupus Erythematosus: A Case Report. ⁶²	Ranjan R...Saxena KN	35047258	2021
15	Severe mitral regurgitation from Libman-Sacks endocarditis treated with MitraClip: a case report. ⁶²	Ningyan W...Khung Keong Y	34661053	2021
16	Left Atrial Wall Thickening Is Crucial to Identify Cardiac Light-Chain Amyloidosis in an Elderly Patient With Libman-Sacks Endocarditis-Like Valvulopathy. ⁶²	Okada S...Kobayashi Y	34234084	2021
17	Autoinflammation leading to autoimmunity in adult-onset Still's disease: more than simple coincidence? ⁶²	Valor-Mendez L...Rech J	34544497	2021
18	Mitral valve 'kissing lesion' in Libman-Sacks endocarditis. ⁶²	Sadeghpour A...Nader ND	33401301	2021
19	Neovascular Glaucoma as a Presenting Sign of Catastrophic Antiphospholipid Syndrome with a "Catastrophic" Heart Valve Finding. ⁶²	Grinberg A...Kesler A	34413759	2021
20	Do all antiphospholipid antibodies confer the same risk for major organ involvement in systemic lupus erythematosus patients? ⁶²	Riancho-Zarrabeitia L...Pego Reigosa JM	32828148	2021
21	Aortic valve surgery for aortic regurgitation caused by Libman-Sacks endocarditis in a patient with primary antiphospholipid syndrome: a case report. ⁶²	Le Ho Y...Abdul Kareem BA	33865405	2021
22	[Libman-Sacks endocarditis under apixaban in a patient with a high-risk profile venous antiphospholipid syndrome]. ⁶²	Allain JS...Jego P	33153775	2021
23	Surgical management of Libman-Sacks mitral valve endocarditis. ⁶²	Abouelela Y...Livesey S	33529822	2021
24	Distinguishing aortic valve thrombus from Libman-Sacks endocarditis in antiphospholipid syndrome: imaging and management. ⁶²	Premyodhin N...Barseghian A	32648500	2021
25	[How to diagnose Libman-Sacks endocarditis with echocardiography?] ⁶²	Bicer A...Altiparmak IH	33390582	2021
26	A Case of Systemic Lupus Erythematosus in a Patient Presenting with Libman-Sacks Endocarditis. ⁶²	Al-Jehani M...Alameen W	34513093	2021
27	Mitral Valve Repair for Isolated Libman-Sacks Endocarditis in a Patient with Primary Antiphospholipid Syndrome. ⁶²	Ye T...Liao S	33518657	2021
28	A 56-Year-Old Woman with Recurrent Strokes: A Clear Case with a Therapeutic Dilemma. ⁶²	Miller ES...Gertner E	33708101	2021
29	Libman-Sacks endocarditis and associated cerebrovascular disease: The role of medical therapy. ⁶²	Roldan CA...Jung RE	33592060	2021
30	Nonbacterial Thrombotic Endocarditis-A Rare Case of Acute Libman-Sacks Endocarditis Complicated by Multiple Cerebral Infarcts: Case Report and Literature Review. ⁶²	Kato T...Kurabayashi M	33376843	2020
31	Cardiogenic Shock and Mitral Valve Chord Rupture: A Rare Presentation of Libman-Sacks Endocarditis. ⁶²	Lampert J...Fuster V	34317095	2020
32	Clinical characteristics and long-term outcomes of Libman-Sacks endocarditis in patients with systemic lupus erythematosus. ⁶²	Yoo BW...Jung SM	32536317	2020
33	Diagnostic performance of aPS/PT antibodies in neuropsychiatric lupus and cardiovascular complications of systemic lupus erythematosus. ⁶²	Ramirez GA...Rovere-Querini P	31782311	2020
34	Hypertrophic obstructive cardiomyopathy and mitral regurgitation in Libman-Sacks endocarditis. ⁶²	Yamashita G...Okabayashi H	30519962	2020
35	Severe mitral valve regurgitation secondary to Libman-Sacks endocarditis. ⁶²	Mizrahi M...Gomez-Sanchez M	33224587	2020
36	Cardiovascular Disease in Antiphospholipid Syndrome. ⁶²	Polytarchou K...Manolis AS	31530257	2020
37	Treatment of Libman-Sacks endocarditis by combination of warfarin and immunosuppressive therapy. ⁶²	Sonsoz MR...Atilgan D	31802766	2019
38	Acute papillary muscle infarction and rupture in the puerperium complicating Libman-Sacks endocarditis in a patient with systemic lupus erythematosus and antiphospholipid syndrome: a case report. ⁶²	Curtis E...Haydock D	32099964	2019
39	Pediatric systemic lupus erythematosus patients in South Africa have high prevalence and severity of cardiac and vascular manifestations. ⁶²	Harrison MJ...Scott C	31771606	2019
40	Libman-Sacks endocarditis in a Bangladeshi patient suffering from rhupus. ⁶²	Zaman S...Ullah M	31180802	2019
41	Ischemic Stroke From Libman-Sacks Endocarditis Not Associated With Antiphospholipid Antibodies: Good Clinical Outcome Without Anticoagulation. ⁶²	Krawczyk M...Sposato LA	34316811	2019
42	Immunosuppressive therapy to reduce mitral regurgitation in Libman-Sacks endocarditis: a case report. ⁶²	Ishizu K...Ando K	31377769	2019
43	Libman-Sacks Endocarditis Involving a Bioprosthesis in the Aortic Valve Position in Systemic Lupus Erythematosus. ⁶²	Roberts WC...Hamman BL	31133276	2019
44	[Effectiveness and safety of selective and non - selective factor Xa inhibitors in antiphospholipid syndrome and systemic lupus erythematosus: anti - Xa - activity range]. ⁶²	Seredavkina NV...Nasonov EL	32598672	2019
45	A case of antiphospholipid syndrome presenting cryptogenically as Budd-Chiari syndrome, then fulminantly as Libman-Sacks endocarditis. ⁶²	Goldhar HA...Castellucci LA	31092489	2019
46	Lung Disease in Antiphospholipid Syndrome. ⁶²	Maioli G...Chighizola CB	31137066	2019
47	Dynamic morphological changes in Libman-Sacks endocarditis under different anticoagulation regimens. ⁶²	Kitano T...Todo K	30948419	2019
48	Cardiac MRI clinches diagnosis of Libman-Sacks endocarditis. ⁶²	Elagha A...Mohsen A	31034381	2019
49	Libman-Sacks Endocarditis in a Puerpera With Systemic Lupus Erythematosus. ⁶²	Liu Y...Liu Y	30266614	2019
50	Libman-Sacks endocarditis in patients with systemic lupus erythematosus with secondary antiphospholipid syndrome. ⁶²	Mohammadi Kebar Y...Hemmati M	31558998	2019

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Genes for Libman-Sacks Endocarditis

Genes related to Libman-Sacks Endocarditis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CFHR2	Complement Factor H Related 2	Protein Coding	9.64	DISEASES inferred ¹⁴ ¹⁴
2	APOH	Apolipoprotein H	Protein Coding	6.16	DISEASES inferred ¹⁴
3	CRP	C-Reactive Protein	Protein Coding	5.3	DISEASES inferred ¹⁴
4	PRTN3	Proteinase 3	Protein Coding	5.06	DISEASES inferred ¹⁴
5	SNRNP70	Small Nuclear Ribonucleoprotein U1 Subunit 70	Protein Coding	4.98	DISEASES inferred ¹⁴
6	TRIM21	Tripartite Motif Containing 21	Protein Coding	4.93	DISEASES inferred ¹⁴
7	C3	Complement C3	Protein Coding	4.85	DISEASES inferred ¹⁴
8	RO60	Ro60, Y RNA Binding Protein	Protein Coding	4.8	DISEASES inferred ¹⁴
9	F2	Coagulation Factor II, Thrombin	Protein Coding	4.56	DISEASES inferred ¹⁴

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Variations for Libman-Sacks Endocarditis

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Expression for Libman-Sacks Endocarditis

Search GEO for disease gene expression data for Libman-Sacks Endocarditis.

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Pathways for Libman-Sacks Endocarditis

Pathways related to Libman-Sacks Endocarditis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) ⁶⁶ Show member pathways Blood clotting cascade ⁷⁴ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Complement and coagulation cascades ⁷⁴ Defective F8 binding to von Willebrand factor ⁶⁶ Defective F8 cleavage by thrombin ⁶⁶ Defective F8 sulfation at Y1699 ⁶⁶ Defective F9 activation ⁶⁶ Defective F9 secretion ⁶⁶ Defective factor IX causes hemophilia B ⁶⁶ Defective factor VIII causes hemophilia A ⁶⁶ Defective factor XII causes hereditary angioedema ⁶⁶ Defective gamma-carboxylation of F9 ⁶⁶ Diseases of hemostasis ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶ Thrombin/protease-activated receptor (PAR) pathway ⁶¹	11.59	PRTN3 F2 C3
2	Complement cascade ⁶⁶ Show member pathways Activation of C3 and C5 ⁶⁶ Classical Complement Pathway ⁶⁴ Complement Pathway ⁶⁴ Complement system ⁷⁴ Complement system in neuronal development and plasticity ⁷⁴ Lectin Induced Complement Pathway ⁶⁴ Regulation of Complement cascade ⁶⁶	11.48	F2 CRP CFHR2 C3

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GO Terms for Libman-Sacks Endocarditis

Biological processes related to Libman-Sacks Endocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of blood coagulation	GO:0030194	9.56	F2 APOH
2	negative regulation of fibrinolysis	GO:0051918	9.46	F2 APOH
3	regulation of blood coagulation	GO:0030193	9.13	F2 APOH
4	cytolysis by host of symbiont cells	GO:0051838	8.92	F2 CFHR2

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Sources for Libman-Sacks Endocarditis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

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¹³ DiseaseEnhancer

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¹⁵ DrugBank

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¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

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²⁹ HMDB

³⁰ HPO

³¹ ICD10

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³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

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⁴³ MeSH

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⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LBM007 MIFTS: 27	Libman-Sacks Endocarditis Categories: Cardiovascular diseases, Immune diseases	Data Licensing For inquiries, contact: [email protected]
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