MCID: LBM007
MIFTS: 27

Libman-Sacks Endocarditis

Categories: Cardiovascular diseases, Immune diseases
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Aliases & Classifications for Libman-Sacks Endocarditis

MalaCards integrated aliases for Libman-Sacks Endocarditis:

Name: Libman-Sacks Endocarditis 11 14 75
Libmann-Sachs, Endocarditis in Systemic Lupus Erythematosus 11

Classifications:



External Ids:

Disease Ontology 11 DOID:0080740

Summaries for Libman-Sacks Endocarditis

Disease Ontology: 11 An endocarditis that is characterized by Libman-Sacks vegetations, is common in patients with systemic lupus erythematosus and is commonly complicated with embolic cerebrovascular disease.

MalaCards based summary: Libman-Sacks Endocarditis, also known as libmann-sachs, endocarditis in systemic lupus erythematosus, is related to endocarditis and mitral valve insufficiency. An important gene associated with Libman-Sacks Endocarditis is CFHR2 (Complement Factor H Related 2), and among its related pathways/superpathways are Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) and Complement cascade. Affiliated tissues include heart, lung and brain.

Wikipedia: 75 Libman-Sacks endocarditis is a form of non-bacterial endocarditis that is seen in association with... more...

Related Diseases for Libman-Sacks Endocarditis

Diseases related to Libman-Sacks Endocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.9 F2 CRP APOH
2 mitral valve insufficiency 31.4 F2 CRP
3 aortic valve insufficiency 31.2 F2 CRP
4 antiphospholipid syndrome 31.1 F2 CRP C3 APOH
5 infective endocarditis 31.1 PRTN3 F2 CRP CFHR2
6 heart valve disease 31.0 F2 CRP APOH
7 intracranial embolism 31.0 F2 CRP
8 mitral valve stenosis 31.0 F2 CRP
9 tricuspid valve insufficiency 30.9 F2 CRP
10 nonbacterial thrombotic endocarditis 30.8 F2 CRP APOH
11 cerebrovascular disease 30.7 F2 CRP APOH
12 stroke, ischemic 30.6 PRTN3 F2 CRP APOH
13 retinal artery occlusion 30.5 F2 CRP APOH
14 facial paralysis 30.5 PRTN3 CRP
15 cellulitis 30.5 F2 CRP
16 patent foramen ovale 30.5 F2 CRP APOH
17 polyarteritis nodosa 30.4 PRTN3 CRP APOH
18 transient cerebral ischemia 30.3 F2 CRP APOH
19 pulmonary embolism 30.3 F2 CRP APOH
20 mitral valve disease 30.3 F2 CRP
21 central retinal artery occlusion 30.2 PRTN3 F2 CRP
22 lupus erythematosus 30.2 TRIM21 SNRNP70 RO60 C3 APOH
23 purpura 30.0 F2 CRP C3 APOH
24 autoimmune disease 30.0 TRIM21 RO60 PRTN3 CRP APOH
25 hypersensitivity reaction type iii disease 29.9 PRTN3 CRP CFHR2 C3
26 thrombocytopenia 29.6 TRIM21 F2 CRP C3 APOH
27 collagen disease 29.4 TRIM21 SNRNP70 PRTN3 CRP CFHR2 APOH
28 systemic lupus erythematosus 29.0 TRIM21 SNRNP70 RO60 PRTN3 F2 CRP
29 systemic lupus erythematosus 1 10.9
30 catastrophic antiphospholipid syndrome 10.5
31 systemic autoimmune disease 10.4
32 diffuse alveolar hemorrhage 10.4
33 cerebral artery occlusion 10.4
34 vitamin k deficiency bleeding 10.4
35 pulmonary edema 10.4
36 pyelonephritis 10.4
37 vascular disease 10.4
38 thrombophilia 10.4
39 cryopyrin-associated periodic syndrome 10.4
40 skeletal tuberculosis 10.2 CRP CFHR2
41 bicipital tenosynovitis 10.2 PRTN3 CRP
42 tenosynovitis 10.2 PRTN3 CRP
43 orbital granuloma 10.2 PRTN3 CRP
44 arteritic anterior ischemic optic neuropathy 10.2 PRTN3 CRP
45 sclerosing keratitis 10.2 PRTN3 CRP
46 anterior scleritis 10.2 PRTN3 CRP
47 scleritis 10.2 PRTN3 CRP
48 lateral medullary syndrome 10.2 PRTN3 CRP
49 multiple cranial nerve palsy 10.2 PRTN3 CRP
50 posterior scleritis 10.2 PRTN3 CRP

Graphical network of the top 20 diseases related to Libman-Sacks Endocarditis:



Diseases related to Libman-Sacks Endocarditis

Symptoms & Phenotypes for Libman-Sacks Endocarditis

Drugs & Therapeutics for Libman-Sacks Endocarditis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884

Search NIH Clinical Center for Libman-Sacks Endocarditis

Genetic Tests for Libman-Sacks Endocarditis

Anatomical Context for Libman-Sacks Endocarditis

Organs/tissues related to Libman-Sacks Endocarditis:

MalaCards : Heart, Lung, Brain

Publications for Libman-Sacks Endocarditis

Articles related to Libman-Sacks Endocarditis:

(show top 50) (show all 229)
# Title Authors PMID Year
1
Severe aortic regurgitation from aortic valve perforation in Libman-Sacks endocarditis: Incremental value of 3D TEE. 62
36354009 2022
2
A Rare Case of Tricuspid Valve Libman-Sacks Endocarditis in a Pregnant Woman with Primary Antiphospholipid Syndrome. 62
36233742 2022
3
Libman-Sacks Endocarditis and Infective Endocarditis Vegetations Coexisting in a Patient With Antiphospholipid Syndrome. 62
35922911 2022
4
[Delayed white matter lesion after mechanical thrombectomy for middle cerebral artery occlusion with Libman-Sacks endocarditis]. 62
36031377 2022
5
Aortic valve Libman‑Sacks endocarditis mimicking papillary fibroelastoma: therapeutic possibilities. 62
35699944 2022
6
All Endocarditis Is Not Infective: Libman-Sacks Endocarditis. 62
35936150 2022
7
[Aortic Valve Replacement for Libman-Sacks Endocarditis:Report of a Case]. 62
35618691 2022
8
Severe Libman-Sacks endocarditis complicating antiphospholipid syndrome: a retrospective analysis of 23 operated cases. 62
35686908 2022
9
Subacute infective endocarditis caused by Bacillus cereus in a patient with Systemic Lupus Erythematosus. 62
35544639 2022
10
Case report: Mitral valve replacement for Libman-Sacks endocarditis and cerebral embolism of primary antiphospholipid syndrome. 62
36061548 2022
11
Mitral valve replacement due to Libman-Sacks endocarditis: lower limb cellulitis as a red herring. 62
35058285 2022
12
[Superinfection of Libman-Sacks endocarditis in a lupus patient: a case report]. 62
36405651 2022
13
Catastrophic anti-phospholipid syndrome with Libman-Sacks endocarditis following eltrombopag therapy for immune thrombocytopenic purpura: A case report. 62
34923861 2021
14
Unveiling Uncommon Manifestations in a Pediatric Patient With Systemic Lupus Erythematosus: A Case Report. 62
35047258 2021
15
Severe mitral regurgitation from Libman-Sacks endocarditis treated with MitraClip: a case report. 62
34661053 2021
16
Left Atrial Wall Thickening Is Crucial to Identify Cardiac Light-Chain Amyloidosis in an Elderly Patient With Libman-Sacks Endocarditis-Like Valvulopathy. 62
34234084 2021
17
Autoinflammation leading to autoimmunity in adult-onset Still's disease: more than simple coincidence? 62
34544497 2021
18
Mitral valve 'kissing lesion' in Libman-Sacks endocarditis. 62
33401301 2021
19
Neovascular Glaucoma as a Presenting Sign of Catastrophic Antiphospholipid Syndrome with a "Catastrophic" Heart Valve Finding. 62
34413759 2021
20
Do all antiphospholipid antibodies confer the same risk for major organ involvement in systemic lupus erythematosus patients? 62
32828148 2021
21
Aortic valve surgery for aortic regurgitation caused by Libman-Sacks endocarditis in a patient with primary antiphospholipid syndrome: a case report. 62
33865405 2021
22
[Libman-Sacks endocarditis under apixaban in a patient with a high-risk profile venous antiphospholipid syndrome]. 62
33153775 2021
23
Surgical management of Libman-Sacks mitral valve endocarditis. 62
33529822 2021
24
Distinguishing aortic valve thrombus from Libman-Sacks endocarditis in antiphospholipid syndrome: imaging and management. 62
32648500 2021
25
[How to diagnose Libman-Sacks endocarditis with echocardiography?] 62
33390582 2021
26
A Case of Systemic Lupus Erythematosus in a Patient Presenting with Libman-Sacks Endocarditis. 62
34513093 2021
27
Mitral Valve Repair for Isolated Libman-Sacks Endocarditis in a Patient with Primary Antiphospholipid Syndrome. 62
33518657 2021
28
A 56-Year-Old Woman with Recurrent Strokes: A Clear Case with a Therapeutic Dilemma. 62
33708101 2021
29
Libman-Sacks endocarditis and associated cerebrovascular disease: The role of medical therapy. 62
33592060 2021
30
Nonbacterial Thrombotic Endocarditis-A Rare Case of Acute Libman-Sacks Endocarditis Complicated by Multiple Cerebral Infarcts: Case Report and Literature Review. 62
33376843 2020
31
Cardiogenic Shock and Mitral Valve Chord Rupture: A Rare Presentation of Libman-Sacks Endocarditis. 62
34317095 2020
32
Clinical characteristics and long-term outcomes of Libman-Sacks endocarditis in patients with systemic lupus erythematosus. 62
32536317 2020
33
Diagnostic performance of aPS/PT antibodies in neuropsychiatric lupus and cardiovascular complications of systemic lupus erythematosus. 62
31782311 2020
34
Hypertrophic obstructive cardiomyopathy and mitral regurgitation in Libman-Sacks endocarditis. 62
30519962 2020
35
Severe mitral valve regurgitation secondary to Libman-Sacks endocarditis. 62
33224587 2020
36
Cardiovascular Disease in Antiphospholipid Syndrome. 62
31530257 2020
37
Treatment of Libman-Sacks endocarditis by combination of warfarin and immunosuppressive therapy. 62
31802766 2019
38
Acute papillary muscle infarction and rupture in the puerperium complicating Libman-Sacks endocarditis in a patient with systemic lupus erythematosus and antiphospholipid syndrome: a case report. 62
32099964 2019
39
Pediatric systemic lupus erythematosus patients in South Africa have high prevalence and severity of cardiac and vascular manifestations. 62
31771606 2019
40
Libman-Sacks endocarditis in a Bangladeshi patient suffering from rhupus. 62
31180802 2019
41
Ischemic Stroke From Libman-Sacks Endocarditis Not Associated With Antiphospholipid Antibodies: Good Clinical Outcome Without Anticoagulation. 62
34316811 2019
42
Immunosuppressive therapy to reduce mitral regurgitation in Libman-Sacks endocarditis: a case report. 62
31377769 2019
43
Libman-Sacks Endocarditis Involving a Bioprosthesis in the Aortic Valve Position in Systemic Lupus Erythematosus. 62
31133276 2019
44
[Effectiveness and safety of selective and non - selective factor Xa inhibitors in antiphospholipid syndrome and systemic lupus erythematosus: anti - Xa - activity range]. 62
32598672 2019
45
A case of antiphospholipid syndrome presenting cryptogenically as Budd-Chiari syndrome, then fulminantly as Libman-Sacks endocarditis. 62
31092489 2019
46
Lung Disease in Antiphospholipid Syndrome. 62
31137066 2019
47
Dynamic morphological changes in Libman-Sacks endocarditis under different anticoagulation regimens. 62
30948419 2019
48
Cardiac MRI clinches diagnosis of Libman-Sacks endocarditis. 62
31034381 2019
49
Libman-Sacks Endocarditis in a Puerpera With Systemic Lupus Erythematosus. 62
30266614 2019
50
Libman-Sacks endocarditis in patients with systemic lupus erythematosus with secondary antiphospholipid syndrome. 62
31558998 2019

Variations for Libman-Sacks Endocarditis

Expression for Libman-Sacks Endocarditis

Search GEO for disease gene expression data for Libman-Sacks Endocarditis.

Pathways for Libman-Sacks Endocarditis

GO Terms for Libman-Sacks Endocarditis

Biological processes related to Libman-Sacks Endocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of blood coagulation GO:0030194 9.56 F2 APOH
2 negative regulation of fibrinolysis GO:0051918 9.46 F2 APOH
3 regulation of blood coagulation GO:0030193 9.13 F2 APOH
4 cytolysis by host of symbiont cells GO:0051838 8.92 F2 CFHR2

Sources for Libman-Sacks Endocarditis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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