Lichen Amyloidosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lichen Amyloidosis

MalaCards integrated aliases for Lichen Amyloidosis:

Name: Lichen Amyloidosis ⁵⁸

Amyloidosis, Primary Cutaneous ⁷¹

Lichen Amyloidosus ⁵⁸

Amyloid Lichen ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare skin diseases

External Ids:

ICD10 via Orphanet ³² E85.4+ L99.0*

Orphanet ⁵⁸ ORPHA49804

SNOMED-CT via HPO ⁶⁹ 25694009 279333002 418290006 more

UMLS ⁷¹ C0268397

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Summaries for Lichen Amyloidosis

Orphanet: ⁵⁸ Lichen amyloidosis is a rare chronic form of cutaneous amyloidosis (see this term), a skin disease characterized by the accumulation of amyloid deposits in the dermis, clinically characterized by the development of pruritic, often pigmented, hyperkeratotic papules on trunk and extremities, especially on the shins, and histologically by the deposition of amyloid or amyloid-like proteins in the papillary dermis.

MalaCards based summary: Lichen Amyloidosis, also known as amyloidosis, primary cutaneous, is related to primary cutaneous amyloidosis and amyloidosis, primary localized cutaneous, 3. An important gene associated with Lichen Amyloidosis is GPNMB (Glycoprotein Nmb), and among its related pathways/superpathways is Interleukin-6 family signaling. The drugs Methylene blue and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and bone marrow, and related phenotypes are papule and pruritus

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Related Diseases for Lichen Amyloidosis

Diseases related to Lichen Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)

#	Related Disease	Score	Top Affiliating Genes
1	primary cutaneous amyloidosis	31.3	OSMR IL31RA GPNMB
2	amyloidosis, primary localized cutaneous, 3	30.8	OSMR IL31RA GPNMB
3	amyloidosis	30.4	OSMR IL31RA GPNMB
4	macular amyloidosis	29.3	OSMR IL31RA GPNMB
5	amyloidosis, primary localized cutaneous, 1	11.7
6	multiple endocrine neoplasia, type iia	11.4
7	amyloidosis, primary localized cutaneous, 2	11.3
8	pigmentary disorder, reticulate, with systemic manifestations, x-linked	11.2
9	multiple endocrine neoplasia	10.5
10	thyroid carcinoma, familial medullary	10.5
11	thyroid carcinoma	10.5
12	thyroid gland medullary carcinoma	10.4
13	pheochromocytoma	10.4
14	kimura disease	10.4
15	dermatitis, atopic	10.3
16	dermatitis	10.3
17	primary localized cutaneous nodular amyloidosis	10.2
18	hyperparathyroidism	10.2
19	skin disease	10.2
20	exanthem	10.1
21	lichen planus	10.1
22	bap1 tumor predisposition syndrome	10.1
23	inherited cancer-predisposing syndrome	10.1
24	nevus, epidermal	10.1
25	varicose veins	10.1
26	immune deficiency disease	10.1
27	ceroid lipofuscinosis, neuronal, 5	10.1
28	epidermolysis bullosa pruriginosa	10.1
29	epidermolysis bullosa	10.1
30	contact dermatitis	10.1
31	epidermolysis bullosa dystrophica	10.1
32	inflammatory linear verrucous epidermal nevus	10.1
33	prurigo nodularis	10.1
34	pigmentation anomaly of the skin	10.1
35	hashimoto thyroiditis	10.0
36	graves disease 1	10.0
37	partington syndrome	10.0
38	intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	10.0
39	primary hyperparathyroidism	10.0
40	thyroiditis	10.0
41	spondyloarthropathy 1	9.9
42	alagille syndrome 1	9.9
43	dilution, pigmentary	9.9
44	hair whorl	9.9
45	ichthyosis vulgaris	9.9
46	contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a	9.9
47	mycosis fungoides	9.9
48	myeloma, multiple	9.9
49	myxedema	9.9
50	rhabdomyosarcoma 2	9.9

Graphical network of the top 20 diseases related to Lichen Amyloidosis:

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Symptoms & Phenotypes for Lichen Amyloidosis

Human phenotypes related to Lichen Amyloidosis:

⁵⁸ ³⁰

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	papule ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0200034
2	pruritus ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000989

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Drugs & Therapeutics for Lichen Amyloidosis

Drugs for Lichen Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Methylene blue

Approved, Investigational

61-73-4

6099

2

Pharmaceutical Solutions

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians: Pilot Study	Unknown status	NCT03068208
2	Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in Asians: Pilot Study	Unknown status	NCT03068156

Search NIH Clinical Center for Lichen Amyloidosis

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Genetic Tests for Lichen Amyloidosis

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Anatomical Context for Lichen Amyloidosis

Organs/tissues related to Lichen Amyloidosis:

MalaCards : Skin, Thyroid, Bone Marrow, Bone

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Publications for Lichen Amyloidosis

Articles related to Lichen Amyloidosis:

(show top 50) (show all 338)

#	Title	Authors	PMID	Year
1	High-Frequency Electrosurgery for Generalized Lichen Amyloidosis. ⁶²	Cai YX...Fan YM	36342257	2022
2	Upadacitinib for treatment-resistant Lichen amyloidosis. ⁶²	Solimani F...Meier K	36394121	2022
3	[Clinical and genetic analysis of seven Chinese pedigrees affected with multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis]. ⁶²	Fang X...Qi X	36082561	2022
4	Refractory cutaneous lichen amyloidosis coexisting with atopic dermatitis responds to the Janus Kinase inhibitor baricitinib. ⁶²	Xia D...Li W	35855568	2022
5	Dermoscopy as a Supportive Tool to Differentiate Lichen Amyloidosus From Clinical Mimickers. ⁶²	Sabban ENC...Maronna E	36159111	2022
6	A unique case of concurrent cutaneous lichen amyloidosis and myxedema. ⁶²	Gaghan L...Lugo-Somolinos A	36259802	2022
7	Diagnosing of primary cutaneous amyloidosis using dermoscopy and reflectance confocal microscopy. ⁶²	Lei W...Ai-E X	35188697	2022
8	Multiple endocrine neoplasia type 2: A review. ⁶²	Mathiesen JS...Feldt-Rasmussen U	33812987	2022
9	Lichen Amyloidosis on the Scalp: A Case Report. ⁶²	Li X...Zhou C	35478776	2022
10	Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland. ⁶²	Guillet C...Kolm I	34525472	2022
11	A Case of Lichen Amyloidosis Successfully Treated with Alitretinoin. ⁶²	Kim JH...Lee UH	35656238	2022
12	Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants. ⁶²	Hamie L...Abbas O	34286474	2021
13	Dermoscopic Features of Lichen Amyloidosis in Caucasians-A Case Series and Literature Review. ⁶²	Zychowska M...Reich A	34684064	2021
14	Elevated basal serum levels of calcitonin and simultaneous surgery of MEN2A-specific tumors. ⁶²	Tang HX...Qi XP	34156257	2021
15	Fractional Erbium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Primary Cutaneous Amyloidosis. ⁶²	Fawzy MM...Osman MA	33731571	2021
16	A case of lichen amyloidosis associated with atopic dermatitis successfully treated with dupilumab: A case report and literature review. ⁶²	Aoki K...Mizukawa Y	34037298	2021
17	Treatment of lichen amyloidosis with fractional CO2 laser and topical steroid: a preliminary study of 10 cases. ⁶²	Wang M...Liu H	33236201	2021
18	Dermatoscopic features of lichen amyloidosis: A case report. ⁶²	Zapata-Salazar NA...Chavez-Alvarez S	33561294	2021
19	Efficacy of 1064-nm Nd:YAG picosecond laser in lichen amyloidosis treatment: clinical and dermoscopic evaluation. ⁶²	Lueangarun S...Tempark T	34493149	2021
20	FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis. ⁶²	Madarkar MS...Koti VR	34123561	2021
21	Successful Treatment of Lichen Amyloidosis Using a Fixed Combination of Halobetasol-Propionate and Tazarotene Lotion. ⁶²	Shoen E...Friedman A	33683084	2021
22	Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy. ⁶²	Humeda Y...Calder K	33423428	2020
23	A case report and differential diagnosis of pruritic pretibial skin lesions. ⁶²	Kecelj B...Zgavec B	32975304	2020
24	Multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis. ⁶²	Malhotra R...Khadgawat R	32847897	2020
25	A primer on the genetics of medullary thyroid cancer. ⁶²	Larouche V...Ezzat S	31896937	2019
26	Successful Treatment of Lichen Amyloidosis With Trichloroacetic Acid Peels. ⁶²	Robinson CG...Jahan-Tigh RR	30234656	2019
27	Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study. ⁶²	Hoxbroe Michaelsen S...Mathiesen JS	30644554	2019
28	Postherpetic hypohidrosis-related isotopic response associated with lichen planus and lichen amyloidosis. ⁶²	Katayama C...Aoyama Y	30977728	2019
29	Symmetric lichen amyloidosis: an atypical location on the bilateral extensor surfaces of the arms. ⁶²	Smogorzewski JM...Young L	31116822	2019
30	Lichen amyloidosis successfully treated with fractional ablative laser CO2: A new alternative therapeutic. ⁶²	Korbi M...Zili J	29400590	2019
31	Clinicopathological Study of Primary Cutaneous Amyloidosis in a Tertiary Care Center of Eastern India Reveals Insignificant Association with Friction, Scrubbing, and Photo-Exposure: How valid is the "Keratinocyte Hypothesis"? ⁶²	Biswas P...Sen S	30745632	2019
32	Image Gallery: Dermoscopy of lichen amyloidosis. ⁶²	Moscarella E...Argenziano G	30508246	2018
33	Enlarging the irradiation spot to include the edge of hyperkeratotic papules using a CO2 surgical laser dramatically improves the treatment of lichen amyloidosus. ⁶²	Kagoyama K...Shimizu T	30325325	2018
34	The RET C611Y mutation causes MEN 2A and associated cutaneous ⁶²	Qi XP...Zhao JQ	30300539	2018
35	An intensely pruritic pebbled presentation. ⁶²	Soriano LF...Ekeowa-Anderson AL	29630157	2018
36	Metastatic pheochromocytoma in MEN 2A: A rare association. ⁶²	Pal R...Bhansali A	29592980	2018
37	The Clinical Spectrum of Multiple Endocrine Neoplasia Type 2A with Cutaneous Lichen Amyloidosis in Ethnic Han Chinese. ⁶²	Qi XP...Jia H	29420094	2018
38	Lichen amyloidosis involving the scalp. ⁶²	Frew JW...Fallah H	28744954	2017
39	Alitretinoin treatment of lichen amyloidosis. ⁶²	Koh WS...Ro YS	28906049	2017
40	Lichen amyloidosis of the scalp and forehead. ⁶²	Kim Y...Chung CG	29447646	2017
41	Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review. ⁶²	Weidner T...Elsner P	28342017	2017
42	Successful treatment of lichen amyloidosis accompanied by atopic dermatitis by fractional CO2 laser. ⁶²	Chu H...Lee KH	28535110	2017
43	Dermatologic manifestations of endocrine disorders. ⁶²	Lause M...Fernandez Faith E	29184811	2017
44	Increase in sensory sensitivity around, but not in the central part of, the hyperkeratotic papule in lichen amyloidosis. ⁶²	Andoh T...Shimizu T	28334422	2017
45	Primary Cutaneous Amyloidosis: A Clinical, Histopathological and Immunofluorescence Study. ⁶²	Mehrotra K...Dewan A	28969251	2017
46	Lichen amyloidosus as a sweat gland/duct-related disorder: resolution associated with restoration of sweating disturbance. ⁶²	Shimoda Y...Aoyama Y	27628905	2017
47	Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. ⁶²	Kono M...Akiyama M	27530091	2017
48	Lichen amyloidosis associated with rheumatoid arthritis: unique presentation in a Bulgarian patient. ⁶²	Tchernev G...Wollina U	28076615	2017
49	Image Gallery: Lichen amyloidosis on the external auditory canal. ⁶²	Shiiya C...Ota M	27996148	2016
50	Dermoscopy in General Dermatology: A Practical Overview. ⁶²	Errichetti E...Stinco G	27613297	2016

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Genes for Lichen Amyloidosis

Genes related to Lichen Amyloidosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GPNMB	Glycoprotein Nmb	Protein Coding	8.05	GeneCards inferred via : Disorders (show sections)
2	IL31RA	Interleukin 31 Receptor A	Protein Coding	8.05	GeneCards inferred via : Disorders (show sections)
3	OSMR	Oncostatin M Receptor	Protein Coding	8.05	GeneCards inferred via : Disorders (show sections)

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Variations for Lichen Amyloidosis

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Expression for Lichen Amyloidosis

Search GEO for disease gene expression data for Lichen Amyloidosis.

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Pathways for Lichen Amyloidosis

Pathways related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Interleukin-6 family signaling ⁶⁶ Show member pathways IL-6-type cytokine receptor ligand interactions ⁶⁶ Immune response Oncostatin M signaling via JAK-Stat in human cells ²² Interleukin-6 signaling ⁶⁶	10.47	OSMR IL31RA

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GO Terms for Lichen Amyloidosis

Cellular components related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	receptor complex	GO:0043235	8.92	OSMR IL31RA

Biological processes related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	8.92	OSMR IL31RA

Molecular functions related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine receptor activity	GO:0004896	9.26	OSMR IL31RA
2	cytokine binding	GO:0019955	8.92	OSMR IL31RA

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Sources for Lichen Amyloidosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LCH014 MIFTS: 29	Lichen Amyloidosis Categories: Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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