MCID: LCH014
MIFTS: 29

Lichen Amyloidosis

Categories: Rare diseases, Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Lichen Amyloidosis

MalaCards integrated aliases for Lichen Amyloidosis:

Name: Lichen Amyloidosis 58
Amyloidosis, Primary Cutaneous 71
Lichen Amyloidosus 58
Amyloid Lichen 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 via Orphanet 32 E85.4+ L99.0*
Orphanet 58 ORPHA49804
UMLS 71 C0268397

Summaries for Lichen Amyloidosis

Orphanet: 58 Lichen amyloidosis is a rare chronic form of cutaneous amyloidosis (see this term), a skin disease characterized by the accumulation of amyloid deposits in the dermis, clinically characterized by the development of pruritic, often pigmented, hyperkeratotic papules on trunk and extremities, especially on the shins, and histologically by the deposition of amyloid or amyloid-like proteins in the papillary dermis.

MalaCards based summary: Lichen Amyloidosis, also known as amyloidosis, primary cutaneous, is related to primary cutaneous amyloidosis and amyloidosis, primary localized cutaneous, 3. An important gene associated with Lichen Amyloidosis is GPNMB (Glycoprotein Nmb), and among its related pathways/superpathways is Interleukin-6 family signaling. The drugs Methylene blue and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and bone marrow, and related phenotypes are papule and pruritus

Related Diseases for Lichen Amyloidosis

Diseases related to Lichen Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 primary cutaneous amyloidosis 31.3 OSMR IL31RA GPNMB
2 amyloidosis, primary localized cutaneous, 3 30.8 OSMR IL31RA GPNMB
3 amyloidosis 30.4 OSMR IL31RA GPNMB
4 macular amyloidosis 29.3 OSMR IL31RA GPNMB
5 amyloidosis, primary localized cutaneous, 1 11.7
6 multiple endocrine neoplasia, type iia 11.4
7 amyloidosis, primary localized cutaneous, 2 11.3
8 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.2
9 multiple endocrine neoplasia 10.5
10 thyroid carcinoma, familial medullary 10.5
11 thyroid carcinoma 10.5
12 thyroid gland medullary carcinoma 10.4
13 pheochromocytoma 10.4
14 kimura disease 10.4
15 dermatitis, atopic 10.3
16 dermatitis 10.3
17 primary localized cutaneous nodular amyloidosis 10.2
18 hyperparathyroidism 10.2
19 skin disease 10.2
20 exanthem 10.1
21 lichen planus 10.1
22 bap1 tumor predisposition syndrome 10.1
23 inherited cancer-predisposing syndrome 10.1
24 nevus, epidermal 10.1
25 varicose veins 10.1
26 immune deficiency disease 10.1
27 ceroid lipofuscinosis, neuronal, 5 10.1
28 epidermolysis bullosa pruriginosa 10.1
29 epidermolysis bullosa 10.1
30 contact dermatitis 10.1
31 epidermolysis bullosa dystrophica 10.1
32 inflammatory linear verrucous epidermal nevus 10.1
33 prurigo nodularis 10.1
34 pigmentation anomaly of the skin 10.1
35 hashimoto thyroiditis 10.0
36 graves disease 1 10.0
37 partington syndrome 10.0
38 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.0
39 primary hyperparathyroidism 10.0
40 thyroiditis 10.0
41 spondyloarthropathy 1 9.9
42 alagille syndrome 1 9.9
43 dilution, pigmentary 9.9
44 hair whorl 9.9
45 ichthyosis vulgaris 9.9
46 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.9
47 mycosis fungoides 9.9
48 myeloma, multiple 9.9
49 myxedema 9.9
50 rhabdomyosarcoma 2 9.9

Graphical network of the top 20 diseases related to Lichen Amyloidosis:



Diseases related to Lichen Amyloidosis

Symptoms & Phenotypes for Lichen Amyloidosis

Human phenotypes related to Lichen Amyloidosis:

58 30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 papule 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0200034
2 pruritus 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0000989

Drugs & Therapeutics for Lichen Amyloidosis

Drugs for Lichen Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational 61-73-4 6099
2 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians: Pilot Study Unknown status NCT03068208
2 Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in Asians: Pilot Study Unknown status NCT03068156

Search NIH Clinical Center for Lichen Amyloidosis

Genetic Tests for Lichen Amyloidosis

Anatomical Context for Lichen Amyloidosis

Organs/tissues related to Lichen Amyloidosis:

MalaCards : Skin, Thyroid, Bone Marrow, Bone

Publications for Lichen Amyloidosis

Articles related to Lichen Amyloidosis:

(show top 50) (show all 338)
# Title Authors PMID Year
1
High-Frequency Electrosurgery for Generalized Lichen Amyloidosis. 62
36342257 2022
2
Upadacitinib for treatment-resistant Lichen amyloidosis. 62
36394121 2022
3
[Clinical and genetic analysis of seven Chinese pedigrees affected with multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis]. 62
36082561 2022
4
Refractory cutaneous lichen amyloidosis coexisting with atopic dermatitis responds to the Janus Kinase inhibitor baricitinib. 62
35855568 2022
5
Dermoscopy as a Supportive Tool to Differentiate Lichen Amyloidosus From Clinical Mimickers. 62
36159111 2022
6
A unique case of concurrent cutaneous lichen amyloidosis and myxedema. 62
36259802 2022
7
Diagnosing of primary cutaneous amyloidosis using dermoscopy and reflectance confocal microscopy. 62
35188697 2022
8
Multiple endocrine neoplasia type 2: A review. 62
33812987 2022
9
Lichen Amyloidosis on the Scalp: A Case Report. 62
35478776 2022
10
Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland. 62
34525472 2022
11
A Case of Lichen Amyloidosis Successfully Treated with Alitretinoin. 62
35656238 2022
12
Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants. 62
34286474 2021
13
Dermoscopic Features of Lichen Amyloidosis in Caucasians-A Case Series and Literature Review. 62
34684064 2021
14
Elevated basal serum levels of calcitonin and simultaneous surgery of MEN2A-specific tumors. 62
34156257 2021
15
Fractional Erbium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Primary Cutaneous Amyloidosis. 62
33731571 2021
16
A case of lichen amyloidosis associated with atopic dermatitis successfully treated with dupilumab: A case report and literature review. 62
34037298 2021
17
Treatment of lichen amyloidosis with fractional CO2 laser and topical steroid: a preliminary study of 10 cases. 62
33236201 2021
18
Dermatoscopic features of lichen amyloidosis: A case report. 62
33561294 2021
19
Efficacy of 1064-nm Nd:YAG picosecond laser in lichen amyloidosis treatment: clinical and dermoscopic evaluation. 62
34493149 2021
20
FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis. 62
34123561 2021
21
Successful Treatment of Lichen Amyloidosis Using a Fixed Combination of Halobetasol-Propionate and Tazarotene Lotion. 62
33683084 2021
22
Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy. 62
33423428 2020
23
A case report and differential diagnosis of pruritic pretibial skin lesions. 62
32975304 2020
24
Multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis. 62
32847897 2020
25
A primer on the genetics of medullary thyroid cancer. 62
31896937 2019
26
Successful Treatment of Lichen Amyloidosis With Trichloroacetic Acid Peels. 62
30234656 2019
27
Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study. 62
30644554 2019
28
Postherpetic hypohidrosis-related isotopic response associated with lichen planus and lichen amyloidosis. 62
30977728 2019
29
Symmetric lichen amyloidosis: an atypical location on the bilateral extensor surfaces of the arms. 62
31116822 2019
30
Lichen amyloidosis successfully treated with fractional ablative laser CO2: A new alternative therapeutic. 62
29400590 2019
31
Clinicopathological Study of Primary Cutaneous Amyloidosis in a Tertiary Care Center of Eastern India Reveals Insignificant Association with Friction, Scrubbing, and Photo-Exposure: How valid is the "Keratinocyte Hypothesis"? 62
30745632 2019
32
Image Gallery: Dermoscopy of lichen amyloidosis. 62
30508246 2018
33
Enlarging the irradiation spot to include the edge of hyperkeratotic papules using a CO2 surgical laser dramatically improves the treatment of lichen amyloidosus. 62
30325325 2018
34
The RET C611Y mutation causes MEN 2A and associated cutaneous 62
30300539 2018
35
An intensely pruritic pebbled presentation. 62
29630157 2018
36
Metastatic pheochromocytoma in MEN 2A: A rare association. 62
29592980 2018
37
The Clinical Spectrum of Multiple Endocrine Neoplasia Type 2A with Cutaneous Lichen Amyloidosis in Ethnic Han Chinese. 62
29420094 2018
38
Lichen amyloidosis involving the scalp. 62
28744954 2017
39
Alitretinoin treatment of lichen amyloidosis. 62
28906049 2017
40
Lichen amyloidosis of the scalp and forehead. 62
29447646 2017
41
Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review. 62
28342017 2017
42
Successful treatment of lichen amyloidosis accompanied by atopic dermatitis by fractional CO2 laser. 62
28535110 2017
43
Dermatologic manifestations of endocrine disorders. 62
29184811 2017
44
Increase in sensory sensitivity around, but not in the central part of, the hyperkeratotic papule in lichen amyloidosis. 62
28334422 2017
45
Primary Cutaneous Amyloidosis: A Clinical, Histopathological and Immunofluorescence Study. 62
28969251 2017
46
Lichen amyloidosus as a sweat gland/duct-related disorder: resolution associated with restoration of sweating disturbance. 62
27628905 2017
47
Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. 62
27530091 2017
48
Lichen amyloidosis associated with rheumatoid arthritis: unique presentation in a Bulgarian patient. 62
28076615 2017
49
Image Gallery: Lichen amyloidosis on the external auditory canal. 62
27996148 2016
50
Dermoscopy in General Dermatology: A Practical Overview. 62
27613297 2016

Variations for Lichen Amyloidosis

Expression for Lichen Amyloidosis

Search GEO for disease gene expression data for Lichen Amyloidosis.

Pathways for Lichen Amyloidosis

Pathways related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.47 OSMR IL31RA

GO Terms for Lichen Amyloidosis

Cellular components related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.92 OSMR IL31RA

Biological processes related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.92 OSMR IL31RA

Molecular functions related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 9.26 OSMR IL31RA
2 cytokine binding GO:0019955 8.92 OSMR IL31RA

Sources for Lichen Amyloidosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....