MCID: LCH014
MIFTS: 28

Lichen Amyloidosis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lichen Amyloidosis

MalaCards integrated aliases for Lichen Amyloidosis:

Name: Lichen Amyloidosis 58
Amyloidosis, Primary Cutaneous 70
Lichen Amyloidosus 58
Amyloid Lichen 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 via Orphanet 33 E85.4+ L99.0*
Orphanet 58 ORPHA49804
UMLS 70 C0268397

Summaries for Lichen Amyloidosis

MalaCards based summary : Lichen Amyloidosis, also known as amyloidosis, primary cutaneous, is related to primary cutaneous amyloidosis and amyloidosis. An important gene associated with Lichen Amyloidosis is RET (Ret Proto-Oncogene), and among its related pathways/superpathways is Cytokine Signaling in Immune system. The drugs Methylene blue and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, and related phenotypes are papule and pruritus

Related Diseases for Lichen Amyloidosis

Diseases related to Lichen Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 primary cutaneous amyloidosis 31.5 OSMR IL31RA IL31
2 amyloidosis 30.1 RET OSMR IL31RA GPNMB
3 dermatitis, atopic 29.8 IL31RA IL31
4 dermatitis 29.8 IL31RA IL31
5 macular amyloidosis 29.3 OSMR IL31RA GPNMB
6 amyloidosis, primary localized cutaneous, 1 11.6
7 amyloidosis, primary localized cutaneous, 2 11.3
8 amyloidosis, primary localized cutaneous, 3 11.3
9 multiple endocrine neoplasia, type iia 11.2
10 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.1
11 multiple endocrine neoplasia 10.5
12 thyroid carcinoma 10.4
13 thyroid carcinoma, familial medullary 10.4
14 thyroid gland medullary carcinoma 10.4
15 pheochromocytoma 10.3
16 adrenal gland pheochromocytoma 10.2
17 exanthem 10.1
18 hyperparathyroidism 10.1
19 skin disease 10.1
20 lichen planus 10.1
21 hereditary paraganglioma-pheochromocytoma syndromes 10.1
22 nevus, epidermal 10.0
23 varicose veins 10.0
24 epidermolysis bullosa pruriginosa 10.0
25 syringoma 10.0
26 epidermolysis bullosa 10.0
27 contact dermatitis 10.0
28 epidermolysis bullosa dystrophica 10.0
29 prurigo nodularis 10.0
30 hashimoto thyroiditis 10.0
31 tumor predisposition syndrome 10.0
32 cutaneous telangiectasia and cancer syndrome, familial 10.0
33 primary hyperparathyroidism 10.0
34 thyroiditis 10.0
35 inherited cancer-predisposing syndrome 10.0
36 spondyloarthropathy 1 9.9
37 alagille syndrome 1 9.9
38 ichthyosis vulgaris 9.9
39 dowling-degos disease 1 9.9
40 rheumatoid arthritis 9.9
41 mycosis fungoides 9.9
42 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 9.9
43 diffuse alopecia areata 9.9
44 malignant pheochromocytoma 9.9
45 chronic urticaria 9.9
46 pemphigoid 9.9
47 anhidrosis 9.9
48 inflammatory spondylopathy 9.9
49 urticaria 9.9
50 keratosis 9.9

Graphical network of the top 20 diseases related to Lichen Amyloidosis:



Diseases related to Lichen Amyloidosis

Symptoms & Phenotypes for Lichen Amyloidosis

Human phenotypes related to Lichen Amyloidosis:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 papule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200034
2 pruritus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000989

Drugs & Therapeutics for Lichen Amyloidosis

Drugs for Lichen Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational 61-73-4
2 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Methylene Blue Mediated Photodynamic Therapy for Primary Localized Cutaneous Amyloidosis Treatment in Asians: Pilot Study Unknown status NCT03068208
2 Efficacy of 308-nm Excimer Laser for Primary Localized Cutaneous Amyloidosis Treatment in Asians: Pilot Study Unknown status NCT03068156

Search NIH Clinical Center for Lichen Amyloidosis

Genetic Tests for Lichen Amyloidosis

Anatomical Context for Lichen Amyloidosis

MalaCards organs/tissues related to Lichen Amyloidosis:

40
Bone Marrow

Publications for Lichen Amyloidosis

Articles related to Lichen Amyloidosis:

(show top 50) (show all 309)
# Title Authors PMID Year
1
Fractional Erbium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Primary Cutaneous Amyloidosis. 61
33731571 2021
2
Successful Treatment of Lichen Amyloidosis Using a Fixed Combination of Halobetasol-Propionate and Tazarotene Lotion. 61
33683084 2021
3
Dermatoscopic features of lichen amyloidosis: A case report. 61
33561294 2021
4
Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy. 61
33423428 2020
5
Treatment of lichen amyloidosis with fractional CO2 laser and topical steroid: a preliminary study of 10 cases. 61
33236201 2020
6
A case report and differential diagnosis of pruritic pretibial skin lesions. 61
32975304 2020
7
Multiple endocrine neoplasia type 2A with cutaneous lichen amyloidosis. 61
32847897 2020
8
A primer on the genetics of medullary thyroid cancer. 61
31896937 2019
9
Successful Treatment of Lichen Amyloidosis With Trichloroacetic Acid Peels. 61
30234656 2019
10
Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study. 61
30644554 2019
11
Postherpetic hypohidrosis-related isotopic response associated with lichen planus and lichen amyloidosis. 61
30977728 2019
12
Symmetric lichen amyloidosis: an atypical location on the bilateral extensor surfaces of the arms. 61
31116822 2019
13
Lichen amyloidosis successfully treated with fractional ablative laser CO2: A new alternative therapeutic. 61
29400590 2019
14
Clinicopathological Study of Primary Cutaneous Amyloidosis in a Tertiary Care Center of Eastern India Reveals Insignificant Association with Friction, Scrubbing, and Photo-Exposure: How valid is the "Keratinocyte Hypothesis"? 61
30745632 2019
15
Image Gallery: Dermoscopy of lichen amyloidosis. 61
30508246 2018
16
Enlarging the irradiation spot to include the edge of hyperkeratotic papules using a CO2 surgical laser dramatically improves the treatment of lichen amyloidosus. 61
30325325 2018
17
The RET C611Y mutation causes MEN 2A and associated cutaneous 61
30300539 2018
18
Metastatic pheochromocytoma in MEN 2A: A rare association. 61
29592980 2018
19
An intensely pruritic pebbled presentation. 61
29630157 2018
20
The Clinical Spectrum of Multiple Endocrine Neoplasia Type 2A with Cutaneous Lichen Amyloidosis in Ethnic Han Chinese. 61
29420094 2018
21
Alitretinoin treatment of lichen amyloidosis. 61
28906049 2017
22
Lichen amyloidosis of the scalp and forehead. 61
29447646 2017
23
Lichen amyloidosis involving the scalp. 61
28744954 2017
24
Increase in sensory sensitivity around, but not in the central part of, the hyperkeratotic papule in lichen amyloidosis. 61
28334422 2017
25
Primary Localized Cutaneous Amyloidosis: A Systematic Treatment Review. 61
28342017 2017
26
Successful treatment of lichen amyloidosis accompanied by atopic dermatitis by fractional CO2 laser. 61
28535110 2017
27
Dermatologic manifestations of endocrine disorders. 61
29184811 2017
28
Primary Cutaneous Amyloidosis: A Clinical, Histopathological and Immunofluorescence Study. 61
28969251 2017
29
Lichen amyloidosus as a sweat gland/duct-related disorder: resolution associated with restoration of sweating disturbance. 61
27628905 2017
30
Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. 61
27530091 2017
31
Lichen amyloidosis associated with rheumatoid arthritis: unique presentation in a Bulgarian patient. 61
28076615 2017
32
Dermoscopy in General Dermatology: A Practical Overview. 61
27613297 2016
33
Image Gallery: Lichen amyloidosis on the external auditory canal. 61
27996148 2016
34
MEN 2A-related cutaneous lichen amyloidosis: report of three kindred and systematic literature review of clinical, biochemical and molecular characteristics. 61
26920351 2016
35
Oral isotretinoin: A new treatment alternative for generalized lichen amyloidosis. 61
27469487 2016
36
Successful treatment of lichen amyloidosis using capsaicin 8% patch. 61
25904403 2016
37
Treatment of primary cutaneous amyloidosis with laser: a review of the literature. 61
26984345 2016
38
Generation of an induced pluripotent stem cell line from a patient with hereditary multiple endocrine neoplasia 2A (MEN2A) syndrome with RET mutation. 61
27558615 2016
39
[Genotype-phenotype correlations in multiple endocrine neoplasia type 2]. 61
27480304 2016
40
Successful treatment of lichen amyloidosus with oral alitretinoin. 61
25715817 2016
41
Genotype-Phenotype Correlation in Indian Patients with MEN2-Associated Pheochromocytoma and Comparison of Clinico-Pathological Attributes with Apparently Sporadic Adrenal Pheochromocytoma. 61
26438242 2016
42
Cutaneous lichen amyloidosis in multiple endocrine neoplasia. 61
26813904 2016
43
Vesicular lesions in lichen amyloidosis. 61
26515863 2015
44
THE AUTOIMMUNE CONSTELLATION IN LICHEN AMYLOIDOSIS. 61
26793847 2015
45
Efficacy of different modes of fractional CO2 laser in the treatment of primary cutaneous amyloidosis: A randomized clinical trial. 61
25946210 2015
46
Fractional 1,550 nm Ytterbium/Erbium fiber laser in the treatment of lichen amyloidosis: clinical and histological study. 61
25771782 2015
47
A Th2 cytokine interleukin-31 signature in a case of sporadic lichen amyloidosis. 61
24573820 2015
48
Bullous variant of familial biphasic lichen amyloidosis: a unique combination of three rare presentations. 61
25657431 2015
49
Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation. 61
26494387 2015
50
Epidermolysis bullosa pruriginosa: a case with a novel mutation and co-existent lichen amyloidosus. 61
25566895 2015

Variations for Lichen Amyloidosis

Expression for Lichen Amyloidosis

Search GEO for disease gene expression data for Lichen Amyloidosis.

Pathways for Lichen Amyloidosis

Pathways related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 RET OSMR IL31RA IL31

GO Terms for Lichen Amyloidosis

Cellular components related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 RET OSMR IL31RA

Biological processes related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.16 RET GPNMB
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.96 RET IL31RA
3 cytokine-mediated signaling pathway GO:0019221 8.8 OSMR IL31RA IL31

Molecular functions related to Lichen Amyloidosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 8.96 OSMR IL31RA
2 cytokine binding GO:0019955 8.62 OSMR IL31RA

Sources for Lichen Amyloidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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