MCID: LCH004
MIFTS: 28

Lichen Disease

Categories: Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Lichen Disease

MalaCards integrated aliases for Lichen Disease:

Name: Lichen Disease 11 14 16 71

Classifications:



External Ids:

Disease Ontology 11 DOID:8574
ICD9CM 34 697.9
SNOMED-CT 68 156376003
ICD10 31 L28.0
UMLS 71 C0023643

Summaries for Lichen Disease

MalaCards based summary: Lichen Disease is related to lichen planus and hilar lung neoplasm, and has symptoms including pruritus and related conditions An important gene associated with Lichen Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include skin, and related phenotypes are immune system and hematopoietic system

Related Diseases for Lichen Disease

Diseases related to Lichen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 802)
# Related Disease Score Top Affiliating Genes
1 lichen planus 30.7 TNF MIR31 MIR142 IL6 IL4 IL17A
2 hilar lung neoplasm 10.5 CD8A CD4
3 oral tuberculosis 10.4 CD8A CD4
4 early yaws 10.4 CD8A CD4
5 external pathological resorption 10.4 TNF IL6
6 ventilation pneumonitis 10.4 CD8A CD4
7 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
8 wissler-fanconi syndrome 10.4 CD8A CD4
9 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
10 herpetiform pemphigus 10.4 DSG3 DSG1
11 gastroduodenitis 10.4 CD8A CD4 CCR6
12 bullous impetigo 10.4 DSG3 DSG1
13 physiological polycythemia 10.4 TNF IL6
14 pompholyx 10.4 DST COL17A1 CCR6
15 encephalitozoonosis 10.4 CD8A CD4
16 senile entropion 10.4 TNF CXCL8
17 gastric lymphoma 10.4 MIR142 ICOSLG CCR6
18 thymic dysplasia 10.4 ICOSLG CD8A CD4
19 neurotic excoriation 10.4 DST COL17A1
20 autoimmune peripheral neuropathy 10.4 ICOSLG CD8A CD4
21 evans' syndrome 10.4 CD8A CD4 CCR6
22 type 1 diabetes mellitus 23 10.4 TNF CD8A CD4
23 infectious anterior uveitis 10.4 TNF IL17A
24 nonspecific interstitial pneumonia 10.4 CD8A CD4 CCR6
25 immunodeficiency 13 10.4 ICOSLG CD8A CD4
26 cork-handlers' disease 10.4 CD8A CD4
27 pemphigus gestationis 10.4 DST DSG3 COL17A1
28 duodenitis 10.4 TNF CD8A CD4
29 autoimmune pancreatitis 10.4 ICOSLG CD4 CCR6
30 selective immunoglobulin deficiency disease 10.4 ICOSLG CD8A CD4
31 granulomatous hepatitis 10.4 TNF CD8A CD4
32 immune-complex glomerulonephritis 10.4 ICOSLG CD8A CD4
33 tertiary syphilis 10.4 TNF CD8A CD4
34 secondary syphilis 10.4 TNF CD8A CD4
35 gastrointestinal tuberculosis 10.4 TNF CD8A CD4
36 abdominal tuberculosis 10.4 TNF CD8A CD4
37 anus cancer 10.4 CD8A CD4 CCR6
38 listeria meningitis 10.4 TNF CD8A
39 immunodeficiency with hyper-igm, type 3 10.4 ICOSLG CD8A CD4
40 coccidioidomycosis 10.4 IL17A CD4 CCR6
41 neurosarcoidosis 10.4 TNF CD8A CD4
42 lymphocytic colitis 10.4 TNF CD8A CD4
43 retinal vasculitis 10.4 TNF CD4 CCR6
44 pernicious anemia 10.4 ICOSLG CD4 CCR6
45 dysgammaglobulinemia 10.4 ICOSLG CD8A CD4
46 parotid disease 10.4 TNF CD8A CD4
47 hepatosplenic t-cell lymphoma 10.4 TNF CD8A CD4
48 marginal zone b-cell lymphoma 10.4 MIR142 ICOSLG CCR6
49 t-cell adult acute lymphocytic leukemia 10.4 CD8A CD4 CCR6
50 adult acute lymphocytic leukemia 10.4 CD8A CD4 CCR6

Graphical network of the top 20 diseases related to Lichen Disease:



Diseases related to Lichen Disease

Symptoms & Phenotypes for Lichen Disease

UMLS symptoms related to Lichen Disease:


pruritus and related conditions

MGI Mouse Phenotypes related to Lichen Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.93 CCR6 CD4 CD8A COL17A1 DSG3 DST
2 hematopoietic system MP:0005397 9.77 CCR6 CD4 CD8A COL17A1 DSG1 DSG3
3 integument MP:0010771 9.36 CD4 CD8A COL17A1 DSG1 DSG3 DST

Drugs & Therapeutics for Lichen Disease

Search Clinical Trials, NIH Clinical Center for Lichen Disease

Genetic Tests for Lichen Disease

Anatomical Context for Lichen Disease

Organs/tissues related to Lichen Disease:

MalaCards : Skin

Publications for Lichen Disease

Variations for Lichen Disease

Expression for Lichen Disease

Search GEO for disease gene expression data for Lichen Disease.

Pathways for Lichen Disease

Pathways related to Lichen Disease according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 TNF IL6 IL4 IL17A ICOSLG DSG1
2
Show member pathways
13.36 TNF IL6 IL4 IL17A CXCL8 CD4
3
Show member pathways
13.24 CCR6 CD4 CXCL8 IL17A IL4 IL6
4
Show member pathways
12.37 TNF IL6 IL4 CXCL8
5
Show member pathways
12.22 TNF IL6 IL17A CXCL8
6
Show member pathways
12.07 TNF IL4 IL17A CD8A CD4
7 12.04 COL17A1 CD8A CD1B CD1A
8 11.95 TNF IL6 IL4 CXCL8
9 11.92 CD4 CD8A IL4 IL6 TNF
10
Show member pathways
11.88 TNF IL6 IL17A CD4
11 11.86 TNF IL6 IL4 IL17A CXCL8
12 11.85 TNF IL4 IL17A CXCL8
13
Show member pathways
11.83 CD4 IL17A IL4 IL6
14
Show member pathways
11.74 IL6 CXCL8 CD8A CD4
15 11.72 IL6 IL4 CXCL8
16 11.71 TNF IL6 CXCL8
17 11.69 TNF IL6 IL4 ICOSLG
18 11.67 CXCL8 IL4 IL6
19 11.66 IL6 IL4 IL17A CD4
20
Show member pathways
11.65 TNF IL4 CXCL8
21
Show member pathways
11.62 TNF IL6 CXCL8
22 11.61 TNF IL6 CXCL8
23 11.61 CXCL8 IL4 IL6 TNF
24
Show member pathways
11.58 TNF IL6 IL4
25 11.51 TNF IL6 CXCL8
26 11.47 TNF IL6 CXCL8
27 11.42 TNF IL6 CD8A CD4 CD1A
28 11.34 TNF IL4 IL17A CD8A CD4 CCR6
29 11.25 TNF IL6 CXCL8
30 11.21 TNF IL6 IL4 IL17A
31 11.09 TNF IL6 IL4 CD4
32 11.01 TNF IL6 CXCL8
33 11 TNF IL6 IL17A CXCL8
34 10.99 TNF IL6 IL4 IL17A CXCL8 COL17A1
35 10.75 IL6 IL4
36 10.67 IL6 CXCL8
37 10.45 TNF IL6 IL4 IL17A CXCL8
38
Show member pathways
10.24 TNF IL6 CXCL8

GO Terms for Lichen Disease

Cellular components related to Lichen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 TNF MIR486-1 MIR31 MIR204 MIR142 IL6
2 external side of plasma membrane GO:0009897 9.53 TNF IL17A ICOSLG CD8A CD4 CD1B

Biological processes related to Lichen Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.18 IL17A ICOSLG CD8A CD4 CD1B CD1A
2 immune system process GO:0002376 9.91 CD1A CD1B CD4 CD8A ICOSLG IL17A
3 calcium-mediated signaling GO:0019722 9.86 TNF CXCL8 CD4 CCR6
4 hemidesmosome assembly GO:0031581 9.81 DST COL17A1
5 positive regulation of mononuclear cell migration GO:0071677 9.8 TNF IL4
6 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.8 IL17A IL6 TNF
7 negative regulation of inflammatory response GO:0050728 9.77 MIR31 MIR204 MIR142 IL4
8 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.76 CD1B CD1A
9 T cell activation GO:0042110 9.76 IL4 ICOSLG CD8A CD4
10 negative regulation of bicellular tight junction assembly GO:1903347 9.65 TNF MIR142
11 immune response GO:0006955 9.53 TNF IL6 IL4 IL17A CXCL8 CD8A
12 positive regulation of neuroinflammatory response GO:0150078 9.35 TNF MIR142 IL6

Molecular functions related to Lichen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA base-pairing translational repressor activity GO:1903231 9.56 MIR486-1 MIR31 MIR204 MIR142
2 exogenous lipid antigen binding GO:0030884 9.46 CD1B CD1A
3 cytokine activity GO:0005125 9.28 TNF IL6 IL4 IL17A CXCL8
4 endogenous lipid antigen binding GO:0030883 9.26 CD1B CD1A

Sources for Lichen Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....