Lichen Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Lichen Disease is related to lichen planus and hilar lung neoplasm, and has symptoms including pruritus and related conditions An important gene associated with Lichen Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include skin, and related phenotypes are immune system and hematopoietic system

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Related Diseases for Lichen Disease

Diseases related to Lichen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 802)

#	Related Disease	Score	Top Affiliating Genes
1	lichen planus	30.7	TNF MIR31 MIR142 IL6 IL4 IL17A
2	hilar lung neoplasm	10.5	CD8A CD4
3	oral tuberculosis	10.4	CD8A CD4
4	early yaws	10.4	CD8A CD4
5	external pathological resorption	10.4	TNF IL6
6	ventilation pneumonitis	10.4	CD8A CD4
7	diffuse infiltrative lymphocytosis syndrome	10.4	CD8A CD4
8	wissler-fanconi syndrome	10.4	CD8A CD4
9	autoimmune lymphoproliferative syndrome, type iia	10.4	CD8A CD4
10	herpetiform pemphigus	10.4	DSG3 DSG1
11	gastroduodenitis	10.4	CD8A CD4 CCR6
12	bullous impetigo	10.4	DSG3 DSG1
13	physiological polycythemia	10.4	TNF IL6
14	pompholyx	10.4	DST COL17A1 CCR6
15	encephalitozoonosis	10.4	CD8A CD4
16	senile entropion	10.4	TNF CXCL8
17	gastric lymphoma	10.4	MIR142 ICOSLG CCR6
18	thymic dysplasia	10.4	ICOSLG CD8A CD4
19	neurotic excoriation	10.4	DST COL17A1
20	autoimmune peripheral neuropathy	10.4	ICOSLG CD8A CD4
21	evans' syndrome	10.4	CD8A CD4 CCR6
22	type 1 diabetes mellitus 23	10.4	TNF CD8A CD4
23	infectious anterior uveitis	10.4	TNF IL17A
24	nonspecific interstitial pneumonia	10.4	CD8A CD4 CCR6
25	immunodeficiency 13	10.4	ICOSLG CD8A CD4
26	cork-handlers' disease	10.4	CD8A CD4
27	pemphigus gestationis	10.4	DST DSG3 COL17A1
28	duodenitis	10.4	TNF CD8A CD4
29	autoimmune pancreatitis	10.4	ICOSLG CD4 CCR6
30	selective immunoglobulin deficiency disease	10.4	ICOSLG CD8A CD4
31	granulomatous hepatitis	10.4	TNF CD8A CD4
32	immune-complex glomerulonephritis	10.4	ICOSLG CD8A CD4
33	tertiary syphilis	10.4	TNF CD8A CD4
34	secondary syphilis	10.4	TNF CD8A CD4
35	gastrointestinal tuberculosis	10.4	TNF CD8A CD4
36	abdominal tuberculosis	10.4	TNF CD8A CD4
37	anus cancer	10.4	CD8A CD4 CCR6
38	listeria meningitis	10.4	TNF CD8A
39	immunodeficiency with hyper-igm, type 3	10.4	ICOSLG CD8A CD4
40	coccidioidomycosis	10.4	IL17A CD4 CCR6
41	neurosarcoidosis	10.4	TNF CD8A CD4
42	lymphocytic colitis	10.4	TNF CD8A CD4
43	retinal vasculitis	10.4	TNF CD4 CCR6
44	pernicious anemia	10.4	ICOSLG CD4 CCR6
45	dysgammaglobulinemia	10.4	ICOSLG CD8A CD4
46	parotid disease	10.4	TNF CD8A CD4
47	hepatosplenic t-cell lymphoma	10.4	TNF CD8A CD4
48	marginal zone b-cell lymphoma	10.4	MIR142 ICOSLG CCR6
49	t-cell adult acute lymphocytic leukemia	10.4	CD8A CD4 CCR6
50	adult acute lymphocytic leukemia	10.4	CD8A CD4 CCR6

Graphical network of the top 20 diseases related to Lichen Disease:

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Symptoms & Phenotypes for Lichen Disease

UMLS symptoms related to Lichen Disease:

pruritus and related conditions

MGI Mouse Phenotypes related to Lichen Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.93	CCR6 CD4 CD8A COL17A1 DSG3 DST
2	hematopoietic system	MP:0005397	9.77	CCR6 CD4 CD8A COL17A1 DSG1 DSG3
3	integument	MP:0010771	9.36	CD4 CD8A COL17A1 DSG1 DSG3 DST

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Drugs & Therapeutics for Lichen Disease

Search Clinical Trials, NIH Clinical Center for Lichen Disease

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Genetic Tests for Lichen Disease

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Anatomical Context for Lichen Disease

Organs/tissues related to Lichen Disease:

MalaCards : Skin

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Publications for Lichen Disease

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Genes for Lichen Disease

Genes related to Lichen Disease (0 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.36	DISEASES inferred ¹⁴ ¹⁴
2	MIR31	MicroRNA 31	RNA Gene	8.98	DISEASES inferred ¹⁴ ¹⁴
3	MIR142	MicroRNA 142	RNA Gene	7.58	DISEASES inferred ¹⁴ ¹⁴
4	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	7.55	DISEASES inferred ¹⁴ ¹⁴
5	COL17A1	Collagen Type XVII Alpha 1 Chain	Protein Coding	7.13	DISEASES inferred ¹⁴
6	CD8A	CD8a Molecule	Protein Coding	7.11	DISEASES inferred ¹⁴
7	CD4	CD4 Molecule	Protein Coding	6.94	DISEASES inferred ¹⁴
8	TNF	Tumor Necrosis Factor	Protein Coding	6.82	DISEASES inferred ¹⁴
9	DST	Dystonin	Protein Coding	6.69	DISEASES inferred ¹⁴
10	DSG3	Desmoglein 3	Protein Coding	6.66	DISEASES inferred ¹⁴
11	DSG1	Desmoglein 1	Protein Coding	6.65	DISEASES inferred ¹⁴
12	MIR486-1	MicroRNA 486-1	RNA Gene	6.47	DISEASES inferred ¹⁴ ¹⁴
13	IL6	Interleukin 6	Protein Coding	6.47	DISEASES inferred ¹⁴
14	IL17A	Interleukin 17A	Protein Coding	6.38	DISEASES inferred ¹⁴
15	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	6.29	DISEASES inferred ¹⁴
16	MIR4484	MicroRNA 4484	RNA Gene	6.26	DISEASES inferred ¹⁴
17	MIR204	MicroRNA 204	RNA Gene	6.25	DISEASES inferred ¹⁴ ¹⁴
18	CD1A	CD1a Molecule	Protein Coding	6.2	DISEASES inferred ¹⁴
19	IL4	Interleukin 4	Protein Coding	6.2	DISEASES inferred ¹⁴
20	CD1B	CD1b Molecule	Protein Coding	6.18	DISEASES inferred ¹⁴
21	IFNG	Interferon Gamma	Protein Coding	6.16	DISEASES inferred ¹⁴
22	CD1E	CD1e Molecule	Protein Coding	6.15	DISEASES inferred ¹⁴
23	PPL	Periplakin	Protein Coding	6.14	DISEASES inferred ¹⁴
24	CD1C	CD1c Molecule	Protein Coding	6.06	DISEASES inferred ¹⁴
25	IL2	Interleukin 2	Protein Coding	6.05	DISEASES inferred ¹⁴
26	IL10	Interleukin 10	Protein Coding	5.96	DISEASES inferred ¹⁴
27	IL1B	Interleukin 1 Beta	Protein Coding	5.92	DISEASES inferred ¹⁴
28	TP53	Tumor Protein P53	Protein Coding	5.92	DISEASES inferred ¹⁴
29	CD1D	CD1d Molecule	Protein Coding	5.88	DISEASES inferred ¹⁴
30	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	5.84	DISEASES inferred ¹⁴
31	EVPL	Envoplakin	Protein Coding	5.81	DISEASES inferred ¹⁴

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Variations for Lichen Disease

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Expression for Lichen Disease

Search GEO for disease gene expression data for Lichen Disease.

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Pathways for Lichen Disease

Pathways related to Lichen Disease according to GeneCards Suite gene sharing:

(show all 38)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.84	TNF IL6 IL4 IL17A ICOSLG DSG1
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.36	TNF IL6 IL4 IL17A CXCL8 CD4
3	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.24	CCR6 CD4 CXCL8 IL17A IL4 IL6
4	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.37	TNF IL6 IL4 CXCL8
5	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.22	TNF IL6 IL17A CXCL8
6	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.07	TNF IL4 IL17A CD8A CD4
7	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	12.04	COL17A1 CD8A CD1B CD1A
8	Spinal cord injury ⁷⁴	11.95	TNF IL6 IL4 CXCL8
9	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.92	CD4 CD8A IL4 IL6 TNF
10	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.88	TNF IL6 IL17A CD4
11	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.86	TNF IL6 IL4 IL17A CXCL8
12	Allograft rejection ⁷⁴	11.85	TNF IL4 IL17A CXCL8
13	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.83	CD4 IL17A IL4 IL6
14	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.74	IL6 CXCL8 CD8A CD4
15	Glucocorticoid receptor regulatory network ⁶¹	11.72	IL6 IL4 CXCL8
16	Burn wound healing ⁷⁴	11.71	TNF IL6 CXCL8
17	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.69	TNF IL6 IL4 ICOSLG
18	AP-1 transcription factor network ⁶¹	11.67	CXCL8 IL4 IL6
19	Th17 cell differentiation pathway ⁷⁴	11.66	IL6 IL4 IL17A CD4
20	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.65	TNF IL4 CXCL8
21	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.62	TNF IL6 CXCL8
22	miRNAs involvement in the immune response in sepsis ⁷⁴	11.61	TNF IL6 CXCL8
23	Lung fibrosis ⁷⁴	11.61	CXCL8 IL4 IL6 TNF
24	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.58	TNF IL6 IL4
25	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.51	TNF IL6 CXCL8
26	Interleukin-10 signaling ⁶⁶	11.47	TNF IL6 CXCL8
27	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.42	TNF IL6 CD8A CD4 CD1A
28	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	TNF IL4 IL17A CD8A CD4 CCR6
29	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.25	TNF IL6 CXCL8
30	Development and heterogeneity of the ILC family ⁷⁴	11.21	TNF IL6 IL4 IL17A
31	Cytokines and inflammatory response ⁷⁴	11.09	TNF IL6 IL4 CD4
32	Overview of nanoparticle effects ⁷⁴	11.01	TNF IL6 CXCL8
33	Prostaglandin signaling ⁷⁴	11	TNF IL6 IL17A CXCL8
34	G-protein signaling_Rap2B regulation pathway ²²	10.99	TNF IL6 IL4 IL17A CXCL8 COL17A1
35	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.75	IL6 IL4
36	COVID-19 adverse outcome pathway ⁷⁴	10.67	IL6 CXCL8
37	Immune infiltration in pancreatic cancer ⁷⁴	10.45	TNF IL6 IL4 IL17A CXCL8
38	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.24	TNF IL6 CXCL8

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GO Terms for Lichen Disease

Cellular components related to Lichen Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.96	TNF MIR486-1 MIR31 MIR204 MIR142 IL6
2	external side of plasma membrane	GO:0009897	9.53	TNF IL17A ICOSLG CD8A CD4 CD1B

Biological processes related to Lichen Disease according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	adaptive immune response	GO:0002250	10.18	IL17A ICOSLG CD8A CD4 CD1B CD1A
2	immune system process	GO:0002376	9.91	CD1A CD1B CD4 CD8A ICOSLG IL17A
3	calcium-mediated signaling	GO:0019722	9.86	TNF CXCL8 CD4 CCR6
4	hemidesmosome assembly	GO:0031581	9.81	DST COL17A1
5	positive regulation of mononuclear cell migration	GO:0071677	9.8	TNF IL4
6	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.8	IL17A IL6 TNF
7	negative regulation of inflammatory response	GO:0050728	9.77	MIR31 MIR204 MIR142 IL4
8	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	9.76	CD1B CD1A
9	T cell activation	GO:0042110	9.76	IL4 ICOSLG CD8A CD4
10	negative regulation of bicellular tight junction assembly	GO:1903347	9.65	TNF MIR142
11	immune response	GO:0006955	9.53	TNF IL6 IL4 IL17A CXCL8 CD8A
12	positive regulation of neuroinflammatory response	GO:0150078	9.35	TNF MIR142 IL6

Molecular functions related to Lichen Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA base-pairing translational repressor activity	GO:1903231	9.56	MIR486-1 MIR31 MIR204 MIR142
2	exogenous lipid antigen binding	GO:0030884	9.46	CD1B CD1A
3	cytokine activity	GO:0005125	9.28	TNF IL6 IL4 IL17A CXCL8
4	endogenous lipid antigen binding	GO:0030883	9.26	CD1B CD1A

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Sources for Lichen Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LCH004 MIFTS: 28	Lichen Disease Categories: Skin diseases	Data Licensing For inquiries, contact: [email protected]
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