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MCID: LCH004
MIFTS: 27

Lichen Disease

Categories: Skin diseases
Genes Related diseases Pathways Symptoms & Phenotypes
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Aliases & Classifications for Lichen Disease

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MalaCards integrated aliases for Lichen Disease:

Name: Lichen Disease 12 15 17 70

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8574
ICD9CM 34 697.9
SNOMED-CT 67 156376003
ICD10 32 L28.0
UMLS 70 C0023643
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Summaries for Lichen Disease

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MalaCards based summary : Lichen Disease is related to lichen planus and cork-handlers' disease, and has symptoms including pruritus and related conditions An important gene associated with Lichen Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Related phenotype is integument.

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Related Diseases for Lichen Disease

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Diseases related to Lichen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 729)
# Related Disease Score Top Affiliating Genes
1 lichen planus 30.3 TNF IL6 IL4 IL17A IFNG DST
2 cork-handlers' disease 10.5 CD8A CD4
3 lichen planus pemphigoides 10.5 DST COL17A1
4 early yaws 10.5 CD8A CD4
5 external pathological resorption 10.5 TNF IL6
6 ventilation pneumonitis 10.5 CD8A CD4
7 scorpion envenomation 10.5 TNF IL6
8 physiological polycythemia 10.5 TNF IL6
9 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
10 latent syphilis 10.4 CD8A CD4
11 neurotic excoriation 10.4 DST COL17A1
12 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
13 tinea imbricata 10.4 DSG3 DSG1
14 rheumatoid arthritis interstitial lung disease 10.4 TNF CD4
15 t-cell adult acute lymphocytic leukemia 10.4 CD8A CD4 CCR6
16 adult acute lymphocytic leukemia 10.4 CD8A CD4 CCR6
17 immunodeficiency with hyper-igm, type 3 10.4 ICOSLG CD8A CD4
18 anogenital venereal wart 10.4 CD8A CD4 CCR6
19 type 1 diabetes mellitus 23 10.4 TNF CD8A CD4
20 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
21 tertiary syphilis 10.4 TNF CD8A CD4
22 cerebritis 10.4 TNF CD8A CD4
23 granulomatous hepatitis 10.4 TNF CD8A CD4
24 viral exanthem 10.4 TNF CD8A CD4
25 neurosarcoidosis 10.4 TNF CD8A CD4
26 retinal vasculitis 10.4 TNF CD4 CCR6
27 syphilitic meningitis 10.4 TNF CD8A CD4
28 duodenitis 10.4 TNF CD8A CD4
29 good syndrome 10.4 TNF CD8A CD4
30 linear iga disease 10.4 DST COL17A1
31 thrombocytopenic purpura, autoimmune 10.4 ICOSLG CD4 CCR6
32 cardiogenic shock 10.4 TNF IL6
33 staphylococcal toxic shock syndrome 10.4 TNF IFNG
34 autoimmune myocarditis 10.4 TNF IFNG
35 hemorrhagic cystitis 10.4 TNF CD8A CD4
36 facial nerve disease 10.4 TNF CD8A CD4
37 brachydactyly, type c 10.4 CD8A CD4 CCR6
38 facial paralysis 10.4 TNF CD8A CD4
39 swine influenza 10.4 TNF CD8A CD4
40 acute retinal necrosis syndrome 10.4 IL6 CD8A CD4
41 pseudomembranous conjunctivitis 10.4 DSG3 DSG1
42 acute laryngopharyngitis 10.4 DST DSG1 COL17A1
43 iga pemphigus 10.4 DSG3 DSG1
44 predominantly cortical thymoma 10.4 CD1E CD1A
45 agammaglobulinemia, x-linked 10.4 ICOSLG CD4 CCR6
46 panophthalmitis 10.4 IFNG CD4
47 spotted fever rickettsiosis 10.4 TNF IFNG
48 polyarticular juvenile idiopathic arthritis 10.4 TNF IFNG
49 tropical endomyocardial fibrosis 10.4 TNF IL4
50 capillary disease 10.4 IL6 ICOSLG CD8A

Graphical network of the top 20 diseases related to Lichen Disease:



Diseases related to Lichen Disease
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Symptoms & Phenotypes for Lichen Disease

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UMLS symptoms related to Lichen Disease:


pruritus and related conditions

MGI Mouse Phenotypes related to Lichen Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.28 CD4 CD8A DSG1 DSG3 IFNG IL17A
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Drugs & Therapeutics for Lichen Disease

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Search Clinical Trials , NIH Clinical Center for Lichen Disease

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Genetic Tests for Lichen Disease

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Anatomical Context for Lichen Disease

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Publications for Lichen Disease

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Variations for Lichen Disease

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Expression for Lichen Disease

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Search GEO for disease gene expression data for Lichen Disease.
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Pathways for Lichen Disease

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Pathways related to Lichen Disease according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.01 TNF IL6 IL4 IL17A IFNG ICOSLG
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.35 TNF IL6 IL4 IL17A IFNG CXCL8
3
PAK Pathway 63
Show member pathways
 13.3 TNF IL6 IL4 IL17A CXCL8 CD4
4
Allograft rejection 1 36
Show member pathways
 12.83 TNF IL6 IL4 IL17A IFNG ICOSLG
5
Immune response NFAT in immune response 23
Show member pathways
 12.64 TNF IL4 IFNG ICOSLG CD4
6
Th17 cell differentiation 36
Show member pathways
 12.64 TNF IL6 IL4 IL17A IFNG CD4
7
Immune response IL-23 signaling pathway 23
Show member pathways
 12.59 TNF IL6 IL17A IFNG CD4
8
T cell receptor signaling pathway 36
Show member pathways
 12.58 TNF IL6 IL4 IL17A IFNG CD8A
9
NF-kappaB Signaling 4
12.57 TNF IL4 IL17A IFNG CD8A
10
IL-17 Family Signaling Pathways 64
Show member pathways
 12.35 TNF IL6 IL4 IL17A IFNG CXCL8
11
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.33 TNF IL6 CXCL8 CCR6
12
Folate Metabolism 1
Show member pathways
 12.33 TNF IL6 IL4 IFNG
13
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.3 TNF IL6 IL4 IL17A IFNG CXCL8
14
Bacterial infections in CF airways 23
Show member pathways
 12.21 TNF IL6 IL4 IFNG CXCL8
15
Tight junction 36
12.2 CD1E CD1C CD1B CD1A
16
Yersinia infection 36
12.11 TNF IL6 CXCL8 CD8A CD4
17
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
12.09 CD8A CD1C CD1B CD1A
18
Spinal Cord Injury 1
12.03 TNF IL6 IL4 IFNG CXCL8
19
IL12-mediated signaling events 1
Show member pathways
 12 IL4 IFNG CD8A CD4
20
Interleukin-4 and 13 signaling 65
12 TNF IL6 IL4 IL17A CXCL8
21
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.93 TNF IL6 IL4 IFNG CD8A CD4
22
Rheumatoid arthritis 36
11.89 TNF IL6 IL17A IFNG CXCL8
23
Th17 Differentiation Pathway 64
Show member pathways
 11.87 IL6 IL4 IL17A IFNG CD4
24
Glucocorticoid receptor regulatory network 1
11.85 IL6 IL4 IFNG CXCL8
25
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.81 TNF IL4 IFNG CXCL8
26
Th1 Differentiation Pathway 64
Show member pathways
 11.76 TNF IL6 IL17A IFNG CD4
27
Pertussis 36
11.75 TNF IL6 CXCL8
28
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.71 TNF IL6 IFNG CXCL8
29
Lung fibrosis 1
11.71 TNF IL6 IL4 CXCL8
30
Innate Lymphoid Cell Differentiation Pathways 64
11.7 TNF IL4 IL17A IFNG CD8A CD4
31
IgA-Producing B Cells in the Intestine 64
11.67 TNF IL6 IL4 ICOSLG CCR6
32
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.65 TNF IFNG CD8A
33
Legionellosis 36
11.62 TNF IL6 CXCL8
34
ATF-2 transcription factor network 1
11.6 IL6 IFNG CXCL8
35
Malaria 36
11.59 TNF IL6 IFNG CXCL8
36
Interleukin-10 signaling 65
11.58 TNF IL6 IL4 CXCL8
37
Dendritic Cells Developmental Lineage Pathway 64
11.57 TNF IL6 IFNG CD8A CD4 CD1C
38
Amoebiasis 36
11.57 TNF IL6 IFNG CXCL8 CD1E CD1C
39
Photodynamic therapy-induced AP-1 survival signaling. 1
11.56 TNF IL6 IFNG
40
Th2 Differentiation Pathway 64
11.51 IL4 IFNG CD4
41
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.5 TNF IL6 IFNG
42
African trypanosomiasis 36
11.39 TNF IL6 IFNG
43
Development and heterogeneity of the ILC family 1
11.31 TNF IL6 IL4 IL17A IFNG
44
Hematopoietic cell lineage 36
11.27 TNF IL6 IL4 CD8A CD4 CD1E
45
Cytokines and Inflammatory Response 1
11.23 TNF IL6 IL4 IFNG CD4
46
Overview of nanoparticle effects 1
11.09 TNF IL6 CXCL8
47
G-protein signaling_Rap2B regulation pathway 23
11.03 TNF IL6 IL4 IL17A CXCL8 COL17A1
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GO Terms for Lichen Disease

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Cellular components related to Lichen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 TNF MIR31 MIR204 IL6 IL4 IL17A
2 integral component of plasma membrane GO:0005887 9.76 TNF COL17A1 CD8A CD4 CD1E CD1C
3 external side of plasma membrane GO:0009897 9.32 TNF IL17A ICOSLG CD8A CD4 CD1E
4 hemidesmosome GO:0030056 9.26 DST COL17A1

Biological processes related to Lichen Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.06 IL17A ICOSLG CD8A CD4 CD1E CD1C
2 positive regulation of gene expression GO:0010628 10.05 TNF IL6 IL4 IFNG CXCL8
3 cytokine-mediated signaling pathway GO:0019221 9.91 TNF IL6 IL4 IL17A CXCL8 CD4
4 adaptive immune response GO:0002250 9.91 IL17A IFNG ICOSLG CD8A CD4 CD1E
5 regulation of immune response GO:0050776 9.85 IL4 COL17A1 CD8A CD1C CD1B CD1A
6 positive regulation of interleukin-6 production GO:0032755 9.83 TNF IL6 IL17A IFNG
7 regulation of insulin secretion GO:0050796 9.81 TNF IL6 IFNG
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 TNF IL6 IL4 IFNG
9 positive regulation of T cell proliferation GO:0042102 9.8 IL6 IL4 CD4
10 humoral immune response GO:0006959 9.8 TNF IL6 IFNG CCR6
11 positive regulation of interleukin-1 beta production GO:0032731 9.78 TNF IL6 IL17A IFNG
12 positive regulation of chemokine production GO:0032722 9.77 TNF IL6 IFNG
13 microglial cell activation GO:0001774 9.75 TNF IL4 IFNG
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.72 TNF IL6 IL17A
15 positive regulation of osteoclast differentiation GO:0045672 9.71 TNF IL17A IFNG
16 T cell activation GO:0042110 9.71 IL4 ICOSLG CD8A CD4
17 negative regulation of amyloid-beta clearance GO:1900222 9.65 TNF IFNG
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL4 IFNG
19 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
20 vascular endothelial growth factor production GO:0010573 9.62 TNF IL6
21 positive regulation of mononuclear cell migration GO:0071677 9.62 TNF IL4
22 positive regulation of T cell mediated cytotoxicity GO:0001916 9.62 CD1E CD1C CD1B CD1A
23 positive regulation of cellular respiration GO:1901857 9.61 IL4 IFNG
24 neuroinflammatory response GO:0150076 9.61 IL4 IFNG
25 positive regulation of interleukin-23 production GO:0032747 9.6 IL17A IFNG
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 TNF IFNG
27 positive regulation of vitamin D biosynthetic process GO:0060557 9.57 TNF IFNG
28 positive regulation of nitrogen compound metabolic process GO:0051173 9.56 TNF IFNG
29 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.46 CD1E CD1C CD1B CD1A
30 immune response GO:0006955 9.44 TNF IL6 IL4 IL17A IFNG CXCL8
31 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.26 CD1E CD1C CD1B CD1A

Molecular functions related to Lichen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.73 TNF IL6 IL4 IL17A IFNG CXCL8
2 lipopeptide binding GO:0071723 9.46 CD1E CD1C CD1B CD1A
3 exogenous lipid antigen binding GO:0030884 9.26 CD1E CD1C CD1B CD1A
4 endogenous lipid antigen binding GO:0030883 8.92 CD1E CD1C CD1B CD1A
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Sources for Lichen Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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