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MCID: LCH004
MIFTS: 30

Lichen Disease

Categories: Skin diseases
Genes Tissues Related diseases Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lichen Disease

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MalaCards integrated aliases for Lichen Disease:

Name: Lichen Disease 12 15 73

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8574
ICD10 33 L28.0 L43.9
ICD9CM 35 697 697.9
SNOMED-CT 68 88996004
UMLS 73 C0023643
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Summaries for Lichen Disease

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MalaCards based summary : Lichen Disease is related to lichen planus and staphylococcal toxic shock syndrome, and has symptoms including pruritus and related conditions An important gene associated with Lichen Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Triamcinolone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone.

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Related Diseases for Lichen Disease

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Diseases related to Lichen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 lichen planus 29.4 COL17A1 CXCL9 CXCR3 DST FLG ICAM1
2 staphylococcal toxic shock syndrome 10.2 IFNG TNF
3 adult dermatomyositis 10.2 TLR9 TNF
4 lichen planus pemphigoides 10.2 COL17A1 DST
5 pemphigoid gestationis 10.2 COL17A1 DST
6 tropical endomyocardial fibrosis 10.2 IL4 TNF
7 endomyocardial fibrosis 10.2 IL4 TNF
8 trichosporonosis 10.2 IFNG TNF
9 linear iga disease 10.2 COL17A1 DST
10 chronic beryllium disease 10.2 IFNG TNF
11 neurotic excoriation 10.2 COL17A1 DST
12 herpetiform pemphigus 10.2 DSG1 DST
13 bacterial infectious disease 10.2 IFNG TLR9 TNF
14 shwartzman phenomenon 10.2 ICAM1 TNF
15 hypersensitivity reaction type iii disease 10.2 ICAM1 TLR9 TNF
16 tungiasis 10.2 IL4 TNF
17 central nervous system vasculitis 10.2 IFNG TLR9 TNF
18 hyperlucent lung 10.2 IFNG IL4
19 herpes gestationis 10.2 COL17A1 DST
20 hypersensitivity reaction type iv disease 10.2 IFNG TLR9 TNF
21 acute necrotizing encephalitis 10.2 FOXP3 IFNG
22 b-cell growth factor 10.2 IFNG IL4
23 human immunodeficiency virus infectious disease 10.2 IFNG TLR9 TNF
24 filariasis 10.2 IFNG TLR9 TNF
25 nickel allergic contact dermatitis 10.2 IFNG IL4
26 arteries, anomalies of 10.2 ICAM1 TLR9 TNF
27 plasmodium vivax malaria 10.2 ICAM1 IFNG TNF
28 lepromatous leprosy 10.2 ICAM1 IFNG TNF
29 pleurisy 10.2 ICAM1 IFNG TNF
30 cardiac sarcoidosis 10.2 IFNG TNF
31 meningitis 10.2 IFNG TLR9 TNF
32 mucocutaneous leishmaniasis 10.2 TLR9 TNF
33 baylisascariasis 10.2 IFNG IL4
34 penicillin allergy 10.2 IFNG IL4
35 keratoconjunctivitis sicca 10.2 IL4 TLR9 TNF
36 autoimmune enteropathy 10.2 FOXP3 ICAM1
37 diversion colitis 10.2 ICAM1 IL4
38 parasitic helminthiasis infectious disease 10.2 IL4 TLR9 TNF
39 autoimmune disease of eyes, ear, nose and throat 10.2 FOXP3 TLR9 TNF
40 conjunctivitis 10.2 ICAM1 IFNG IL4
41 cryptococcosis 10.2 IFNG IL4 TLR9
42 autoimmune myocarditis 10.2 IFNG IL4 TNF
43 atopic keratoconjunctivitis 10.2 IFNG IL4
44 scleritis 10.2 IFNG IL4 TNF
45 gastrointestinal system disease 10.2 IFNG TLR9 TNF
46 bronchial disease 10.2 IL4 TLR9 TNF
47 leukocyte disease 10.1 IL4 TLR9 TNF
48 autoimmune disease of skin and connective tissue 10.1 COL17A1 DSG1 DST
49 primary systemic mycosis 10.1 IFNG IL4 TNF
50 mycoplasma pneumoniae pneumonia 10.1 IFNG IL4 TNF

Graphical network of the top 20 diseases related to Lichen Disease:



Diseases related to Lichen Disease
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Symptoms & Phenotypes for Lichen Disease

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UMLS symptoms related to Lichen Disease:


pruritus and related conditions
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Drugs & Therapeutics for Lichen Disease

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Drugs for Lichen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 197)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 124-94-7 31307
2
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
3 tannic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
4
Tacrolimus Approved, Investigational Phase 4,Phase 2,Not Applicable 104987-11-3 445643 439492
5
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
6
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 137071-32-0 6447131 17753757
7
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 22916-47-8 4189
10
Chitosan Approved Phase 4 9012-76-4 71853
11
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
13
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
14
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2 302-25-0
15 Lycopene Approved, Investigational Phase 4,Phase 2 502-65-8 446925
16
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2 2921-57-5
17
Insulin glulisine Approved Phase 4 207748-29-6
18
Zinc Approved, Investigational Phase 4 7440-66-6
19
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
20
Prednisolone hemisuccinate Experimental Phase 4,Phase 2 2920-86-7
21
Lactitol Investigational Phase 4 585-86-4 3871
22 Immunologic Factors Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
25 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
26 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
27 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
29 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
30 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
31 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
32 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
33 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
34 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
35 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
40 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
41 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
42 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2,Not Applicable
44 Dermatologic Agents Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
45 Analgesics Phase 4,Phase 3,Phase 2,Early Phase 1
46 Antirheumatic Agents Phase 4,Phase 3,Phase 2
47 Betamethasone benzoate Phase 4,Phase 3,Phase 2,Not Applicable
48 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 Betamethasone Valerate Phase 4,Phase 3,Phase 2,Not Applicable 2152-44-5
50 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 120)
# Name Status NCT ID Phase Drugs
1 Management of Pain in Oral Lichen Planus Completed NCT03572959 Phase 4 0.1 % topical triamcinolone acetonide
2 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
3 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4 lycopene;Prednisolone
4 Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
5 Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia Recruiting NCT03422640 Phase 4 Apremilast
6 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
7 Pain Outcomes Following Intralesional Corticosteroid Injections Not yet recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
8 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
9 Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT Unknown status NCT01282515 Phase 2, Phase 3 clobetasolpropionate;hexaminolevulinate
10 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
11 Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
12 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus Completed NCT02421770 Phase 3
13 Photodynamic Therapy for Oral Precursor Lesions Completed NCT01497951 Phase 3
14 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3 Clobetasol Propionate 0.05% ointment
15 Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
16 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
17 Pilot Study of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus Unknown status NCT01041625 Phase 2 Apremilast (CC-10004)
18 Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin Unknown status NCT01538732 Phase 2 alitretinoin
19 Treatmant of Oral Lichen Planus With Lycopene Completed NCT00656214 Phase 2 Lycopene;Placebo
20 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
21 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
22 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
23 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
24 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2 Tacrolimus cream;Clobetasol cream
25 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
26 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
27 Cedar Honey in Oral Lichen Planus Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
28 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
29 Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
30 Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus Completed NCT00393263 Phase 2 pimecrolimus and clobetasol;clobetasol 0.05% cream
31 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
32 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
33 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
34 A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant Prurigo Nodularis (PN) Completed NCT02196324 Phase 2 serlopitant;Placebo
35 Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS). Completed NCT01835587 Phase 1, Phase 2 CC-486
36 Valchlor in the Treatment of Lichen Planopilaris Recruiting NCT03417141 Phase 2 Valchlor
37 Dexamethasone Solution for the Treatment of Oral Lichen Planus Recruiting NCT02850601 Phase 2 Dexamethasone
38 Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus Recruiting NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
39 Topical INCB018424 Lichen Planus Recruiting NCT03697460 Phase 2 INCB018424
40 Intra-oral Treatment of OLP With Rivelin®-CLO Patches Recruiting NCT03592342 Phase 2 Clobetasol Propionate
41 Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus Active, not recruiting NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
42 A Study of Lenalidomide in Pediatric Subjects With Relapsed or Refractory Acute Myeloid Leukemia Active, not recruiting NCT02538965 Phase 2 Lenalidomide
43 THE AP-GELP STUDY: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus Not yet recruiting NCT03656666 Phase 2 Apremilast;Placebo
44 Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus Not yet recruiting NCT03293368 Phase 2 Triamcinolone Acetonide
45 Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Not yet recruiting NCT03509675 Phase 2 Non-Steroidal Anti-inflammatory Topical Rinse;Placebos
46 Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus Terminated NCT01126255 Phase 2 Clobetasol propionate 0.05%;Progesterone 8%
47 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
48 Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream Terminated NCT00321750 Phase 2 1% pimecrolimus cream
49 A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus Terminated NCT00135733 Phase 2 Amevive (Alefacept);Placebo
50 Use of Etanercept in the Treatment of Moderate to Severe Lichen Planus Terminated NCT00285779 Phase 2 Etanercept;Placebo

Search NIH Clinical Center for Lichen Disease

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Genetic Tests for Lichen Disease

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Anatomical Context for Lichen Disease

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MalaCards organs/tissues related to Lichen Disease:

41
Skin, Lung, Bone, Eye, Tonsil, Thyroid, B Cells
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Publications for Lichen Disease

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Variations for Lichen Disease

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Expression for Lichen Disease

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Search GEO for disease gene expression data for Lichen Disease.
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Pathways for Lichen Disease

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Pathways related to Lichen Disease according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 37
Show member pathways
 12.71 CXCL9 FOXP3 ICAM1 IFNG IL4 TNF
2
Th17 cell differentiation 37
Show member pathways
 12.47 FOXP3 IFNG IL4 TNF
3
NF-kappaB Signaling 4
12.39 FOXP3 IFNG IL4 TLR9 TNF
4
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.38 ICAM1 IFNG IL4 TNF
5
Selenium Micronutrient Network 1
Show member pathways
 12.2 ICAM1 IFNG IL4 TNF
6
Influenza A 37
Show member pathways
 12.19 ICAM1 IFNG IL4 MX1 PABPN1 TLR9
7
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.14 IFNG IL4 MX1 TNF
8
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.09 COL17A1 CXCL9 CXCR3 ICAM1 TLR9
9
Bacterial infections in CF airways 22
Show member pathways
 12.04 IFNG IL4 TLR9 TNF
10
Th1 Differentiation Pathway 65
Show member pathways
 11.93 IFNG TLR9 TNF
11
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.91 IFNG IL4 TNF
12
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.86 IFNG IL4 TNF
13
Interleukin-4 and 13 signaling 66
11.85 ICAM1 IL4 TNF
14
Spinal Cord Injury 1
11.81 ICAM1 IFNG IL4 TNF
15
Rheumatoid arthritis 37
11.73 ICAM1 IFNG TNF
16
Glucocorticoid receptor regulatory network 1
11.67 ICAM1 IFNG IL4
17
Dendritic Cells Developmental Lineage Pathway 65
11.62 IFNG TLR9 TNF
18
Innate Lymphoid Cell Differentiation Pathways 65
11.57 CXCR3 IFNG IL4 TNF
19
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.53 ICAM1 IFNG TNF
20
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.5 FOXP3 IFNG IL4 TNF
21
Interleukin-10 signaling 66
11.41 ICAM1 IL4 TNF
22
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.41 CXCL9 IFNG IL4 TNF
23
Th2 Differentiation Pathway 65
11.38 FOXP3 IFNG IL4
24
Type II interferon signaling (IFNG) 1
11.25 CXCL9 ICAM1 IFNG
25
Malaria 37
11.15 ICAM1 IFNG TLR9 TNF
26
Development and heterogeneity of the ILC family 1
11.14 IFNG IL4 TNF
27
Cytokines and Inflammatory Response 1
11.04 IFNG IL4 TNF
28
LDL Oxidation in Atherogenesis 64
10.82 ICAM1 TNF
29
African trypanosomiasis 37
10.47 ICAM1 IFNG TLR9 TNF
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GO Terms for Lichen Disease

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Cellular components related to Lichen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 CXCL9 CXCR3 ICAM1 TNF
2 hemidesmosome GO:0030056 8.96 COL17A1 DST
3 cornified envelope GO:0001533 8.8 DSG1 FLG IVL

Biological processes related to Lichen Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.93 CXCR3 DSG1 DST ICAM1 LPP
2 inflammatory response GO:0006954 9.88 CXCL9 CXCR3 TLR9 TNF
3 positive regulation of gene expression GO:0010628 9.83 FOXP3 IFNG IL4 TLR9 TNF
4 defense response to virus GO:0051607 9.76 CXCL9 IFNG MX1 TLR9
5 cornification GO:0070268 9.72 DSG1 FLG IVL
6 cellular response to lipopolysaccharide GO:0071222 9.71 CXCL9 ICAM1 PABPN1 TNF
7 positive regulation of osteoclast differentiation GO:0045672 9.59 IFNG TNF
8 positive regulation of chemokine production GO:0032722 9.58 TLR9 TNF
9 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IFNG TNF
10 regulation of regulatory T cell differentiation GO:0045589 9.56 FOXP3 IFNG
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 ICAM1 IFNG TNF
12 hemidesmosome assembly GO:0031581 9.52 COL17A1 DST
13 negative regulation of interleukin-17 production GO:0032700 9.51 FOXP3 IFNG
14 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.49 TLR9 TNF
15 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.48 ICAM1 TNF
16 negative regulation of interleukin-6 production GO:0032715 9.43 FOXP3 TLR9 TNF
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
18 response to virus GO:0009615 9.26 FOXP3 IFNG MX1 TNF
19 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 IFNG TNF
20 immune response GO:0006955 9.1 CXCL9 CXCR3 IFNG IL4 TLR9 TNF

Molecular functions related to Lichen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.8 COL17A1 CXCL9 DSG1 DST FLG FOXP3
2 cytokine activity GO:0005125 8.92 CXCL9 IFNG IL4 TNF
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Sources for Lichen Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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