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MCID: LCH002
MIFTS: 57

Lichen Planus

Categories: Skin diseases, Genetic diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lichen Planus

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MalaCards integrated aliases for Lichen Planus:

Name: Lichen Planus 12 76 37 55 44 15 73
Lichen, Ruber Planus 12
Lichen Ruber Planus 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9201
ICD10 33 L43 L43.9
ICD9CM 35 697.0
MeSH 44 D008010
NCIt 50 C3189
KEGG 37 H01654
UMLS 73 C0023646
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Summaries for Lichen Planus

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Disease Ontology : 12 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes.

MalaCards based summary : Lichen Planus, also known as lichen, ruber planus, is related to lichen planus pemphigoides and lichen sclerosus, and has symptoms including pruritus An important gene associated with Lichen Planus is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Akt Signaling and Allograft rejection. The drugs Triamcinolone and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue or and skin, and related phenotypes are Increased gamma-H2AX phosphorylation and digestive/alimentary

Wikipedia : 76 Lichen planus (LP) is a disease characterized by itchy reddish-purple polygon-shaped skin lesions on the... more...

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Related Diseases for Lichen Planus

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Diseases in the Lichen Planus family:

Lichen Planus, Familial Rare Lichen Planus

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 349)
# Related Disease Score Top Affiliating Genes
1 lichen planus pemphigoides 35.4 COL17A1 DST
2 lichen sclerosus 31.8 GZMB TNF TP53
3 gingivitis 31.5 DEFB4A IL4 TNF
4 graft-versus-host disease 31.3 GZMB IFNG TNF
5 periodontitis 31.0 IFNG IL4 TLR9 TNF
6 linear iga disease 30.9 COL17A1 DST
7 pemphigoid gestationis 30.9 COL17A1 DST
8 pemphigus 30.9 COL17A1 DSG3 DST
9 paraneoplastic pemphigus 30.9 COL17A1 DSG3 DST
10 myasthenia gravis 30.8 IFNG IL4 TNF
11 conjunctivitis 30.8 ICAM1 IFNG IL4
12 helicobacter pylori infection 30.8 IFNG TNF TP53
13 erythema multiforme 30.6 CXCR3 GZMB ICAM1 IFNG TNF
14 viral hepatitis 30.6 MX1 TLR9 TNF
15 acute graft versus host disease 30.5 GZMB IFNG IL4 TNF
16 keratosis 30.5 FLG IVL KRT10
17 filariasis 30.5 IFNG TLR9 TNF
18 cutaneous lupus erythematosus 30.2 CXCR3 GZMB ICAM1 MX1 TNF
19 keratoconjunctivitis 30.1 ICAM1 IFNG IL4 TLR9 TNF
20 tinea corporis 30.0 DEFB4A KRT16
21 keratoacanthoma 29.9 FLG GZMB KRT10 KRT16 TP53
22 epidermolytic hyperkeratosis 29.9 FLG KRT10 KRT16
23 bullous pemphigoid 29.7 COL17A1 DSG3 DST IVL
24 alopecia areata 29.7 CXCL9 GZMB ICAM1 IFNG TNF
25 autoimmune disease 29.6 COL17A1 CXCR3 IFNG IL4 TLR9 TNF
26 allergic contact dermatitis 29.6 CXCR3 FLG ICAM1 IFNG IL4 TNF
27 systemic lupus erythematosus 29.6 CXCR3 ICAM1 IFNG IL4 TLR9 TNF
28 discoid lupus erythematosus 29.3 FLG GZMB IVL KRT10 KRT16
29 rheumatoid arthritis 29.2 FLG ICAM1 IFNG IL4 ITGAL TNF
30 contact dermatitis 29.2 CXCR3 FLG ICAM1 IFNG IL4 KRT16
31 asthma 29.2 FLG ICAM1 IFNG IL4 TLR9 TNF
32 papilloma 29.0 FLG IL4 IVL KRT10 KRT13 TP53
33 basal cell carcinoma 28.8 IVL KRT10 KRT16 TP53
34 mycosis fungoides 28.8 CXCL9 CXCR3 GZMB ITGAL
35 lichen disease 28.5 COL17A1 CXCR3 DST ICAM1 IFNG IL4
36 dermatitis, atopic 27.7 CXCR3 DEFB4A FLG ICAM1 IFNG IL4
37 multiple sclerosis 27.1 CXCL9 CXCR3 ICAM1 IFNG IL4 ITGAL
38 psoriasis 24.3 CXCL9 CXCR3 DEFB4A FLG ICAM1 IFNG
39 actinic lichen planus 12.7
40 lichen planus pigmentosus 12.7
41 linear lichen planus 12.7
42 oral lichen planus 12.7
43 atrophic lichen planus 12.7
44 annular lichen planus 12.7
45 annular atrophic lichen planus 12.6
46 bullous lichen planus 12.4
47 rare lichen planus 12.4
48 lichen planopilaris 12.1
49 lichen planus, familial 12.1
50 graham-little-piccardi-lassueur syndrome 11.9

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to Lichen Planus
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Symptoms & Phenotypes for Lichen Planus

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UMLS symptoms related to Lichen Planus:


pruritus

GenomeRNAi Phenotypes related to Lichen Planus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.28 COL17A1 CXCL9 CXCR3 DEFB4A DSG3 IVL

MGI Mouse Phenotypes related to Lichen Planus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 DSG3 ICAM1 IFNG IL4 KRT16 TLR9
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Drugs & Therapeutics for Lichen Planus

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Drugs for Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 132)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 124-94-7 31307
2
Tacrolimus Approved, Investigational Phase 4,Phase 2,Not Applicable 104987-11-3 445643 439492
3
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
4
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
5
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 137071-32-0 6447131 17753757
6
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 22916-47-8 4189
8
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
10 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
11
Chitosan Approved, Nutraceutical Phase 4 9012-76-4 71853
12
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
13 Lycopene Approved, Investigational, Nutraceutical Phase 4,Phase 2 502-65-8 446925
14
Lactitol Investigational Phase 4 585-86-4 3871
15 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
16 Betamethasone Valerate Phase 4,Phase 3,Phase 2,Not Applicable 2152-44-5
17 Analgesics Phase 4,Phase 3,Phase 2
18 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
19 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
21 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
22 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Dermatologic Agents Phase 4,Phase 2,Phase 3,Early Phase 1
24 Angiogenesis Inhibitors Phase 4,Phase 2
25 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
26 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
27 Hormones Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
28 Angiogenesis Modulating Agents Phase 4,Phase 2
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
30 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
31 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
32 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
33 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
34 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
35 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
36 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
37 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
40 Antirheumatic Agents Phase 4,Phase 3,Phase 2
41 Autonomic Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
42 Betamethasone benzoate Phase 4,Phase 3,Phase 2,Not Applicable
43 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2,Not Applicable
44 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2,Not Applicable
45 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
46 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
47 Prednisolone acetate Phase 4,Phase 2
48 Methylprednisolone acetate Phase 4,Phase 2
49 Methylprednisolone Hemisuccinate Phase 4,Phase 2
50 Neuroprotective Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 71)
# Name Status NCT ID Phase Drugs
1 Management of Pain in Oral Lichen Planus Completed NCT03572959 Phase 4 0.1 % topical triamcinolone acetonide
2 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
3 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4 lycopene;Prednisolone
4 Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
5 Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia Not yet recruiting NCT03422640 Phase 4 Apremilast
6 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
7 Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT Unknown status NCT01282515 Phase 2, Phase 3 clobetasolpropionate;hexaminolevulinate
8 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
9 Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
10 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus Completed NCT02421770 Phase 3
11 Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
12 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
13 Pilot Study of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus Unknown status NCT01041625 Phase 2 Apremilast (CC-10004)
14 Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin Unknown status NCT01538732 Phase 2 alitretinoin
15 Treatmant of Oral Lichen Planus With Lycopene Completed NCT00656214 Phase 2 Lycopene;Placebo
16 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
17 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
18 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
19 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
20 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
21 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
22 Cedar Honey in Oral Lichen Planus Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
23 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
24 Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
25 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
26 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
27 Dexamethasone Solution for the Treatment of Oral Lichen Planus Recruiting NCT02850601 Phase 2 Dexamethasone
28 Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus Recruiting NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
29 Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus Recruiting NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
30 Valchlor in the Treatment of Lichen Planopilaris Recruiting NCT03417141 Phase 2 Valchlor
31 Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus Not yet recruiting NCT03293368 Phase 2 Triamcinolone Acetonide
32 Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Not yet recruiting NCT03509675 Phase 2 Non-Steroidal Anti-inflammatory Topical Rinse;Placebos
33 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
34 Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream Terminated NCT00321750 Phase 2 1% pimecrolimus cream
35 A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus Terminated NCT00135733 Phase 2 Amevive (Alefacept);Placebo
36 Use of Etanercept in the Treatment of Moderate to Severe Lichen Planus Terminated NCT00285779 Phase 2 Etanercept;Placebo
37 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain Terminated NCT01584947 Phase 2 Bupivacaine;Placebo
38 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
39 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1 placebo;Quercetin
40 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Unknown status NCT02532166 Not Applicable
41 Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus Unknown status NCT02276573 Not Applicable
42 Based on Metabonomics Dryness Pathogen Type of OLP: a Dynamic Study Unknown status NCT02332486 Not Applicable Qingxuan Decoction
43 Off-Label Use of Ribavirin in Management of Mucocutaneous Extrahepatic Manifestations of HCV Infection Unknown status NCT02261662 Not Applicable Ribavirin;Betamethasone
44 Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen Planus Completed NCT02834520
45 Serum Cortisol Levels in Patients With Anxiety and Depression With Symptomatic Oral Lichen Planus Completed NCT03011658 Not Applicable
46 The Association Between Diabetes Mellitus, Oral Lichen Planus and Insulin-like Growth Factors 1 and 2 (IGF1 and IGF2) Completed NCT03257228
47 Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients Completed NCT02154607 Not Applicable
48 The Use of Probiotics in Patients With Symptomatic Oral Lichen Planus Completed NCT01743690 Not Applicable Nystatin;fluocinolone
49 Safety and Effectiveness of Efalizumab to Treat Oral Lichen Planus Completed NCT00133107 Not Applicable efalizumab
50 Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity Completed NCT03026361

Search NIH Clinical Center for Lichen Planus

Cochrane evidence based reviews: lichen planus

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Genetic Tests for Lichen Planus

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Anatomical Context for Lichen Planus

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The Foundational Model of Anatomy Ontology organs/tissues related to Lichen Planus:

19
Skin, Tongue Or

MalaCards organs/tissues related to Lichen Planus:

41
Skin, Tongue, T Cells, Thyroid, Testes, Endothelial, Liver
Sources

Publications for Lichen Planus

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Articles related to Lichen Planus:

(show top 50) (show all 1602)
# Title Authors Year
1
Frontal Fibrosing Alopecia and Concomitant Lichen Planus Pigmentosus: A Case Series of Seven African American Women. ( 29601616 )
2018
2
Topical pimecrolimus versus betamethasone for oral lichen planus: a randomized clinical trial. ( 29909565 )
2018
3
Participation of the Th17 response in the pathogenesis of oral lichen planus. ( 29314294 )
2018
4
Randomized, placebo-controlled, double-blind trial of clobetasol propionate 0.05% in the treatment of oral lichen planus. ( 29297958 )
2018
5
MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). ( 29813046 )
2018
6
Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study. ( 29731693 )
2018
7
Chronic graft versus host disease presenting as lichen planus pigmentosus. ( 29410549 )
2018
8
The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus. ( 29412487 )
2018
9
Hepatitis C screening in patients with oral lichen planus. ( 29971956 )
2018
10
Lichen planus pemphigoides. ( 29465781 )
2018
11
Bacillus Calmette-Guerin, polysaccharide nucleic acid in the treatment of cutaneous and oral lichen planus. ( 29405515 )
2018
12
Vulvo-vaginal lichen planus: A focussed review for the clinician. ( 29961956 )
2018
13
Lichen planus pigmentosus inversus in children: Case report and updated review of the literature. ( 29231269 )
2018
14
A retrospective study of lichen planus pigmentosus with focus on palmoplantar involvement. ( 29947025 )
2018
15
Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review. ( 29350426 )
2018
16
Does transcutaneous electrical nerve stimulation have an antipruritic effect in lichen planus? A randomized clinical trial. ( 29947141 )
2018
17
Efficacy of photodynamic therapy and low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus. ( 29414735 )
2018
18
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( 29308937 )
2018
19
Beltlike lichen planus pigmentosus complicated with focal amyloidosis. ( 29894539 )
2018
20
Zosteriform Lichen Planus Pigmentosus Altering Segmental Vitiligo. ( 29911535 )
2018
21
Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus. ( 29854885 )
2018
22
Linear bullous lichen planus associated with nivolumab. ( 29920744 )
2018
23
Comment on "Xerostomia and Salivary Gland Hypofunction in Patients with Oral Lichen Planus Before and After Treatment with Topical Corticosteroids". ( 29760823 )
2018
24
Oral lichen planus and HPV lesions. ( 29875955 )
2018
25
Rate of malignant transformation of oral lichen planus: A systematic review. ( 29738106 )
2018
26
Gastric parietal cell and thyroid autoantibodies in recurrent aphthous stomatitis patients with concomitant oral lichen planus. ( 29753458 )
2018
27
Expression and clinical significance of periostin in oral lichen planus. ( 29805541 )
2018
28
Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus. ( 29875865 )
2018
29
Lack of Association between Oral Lichen Planus and Hepatitis B and C Virus Infection - a Report from Southeast Iran ( 29936791 )
2018
30
Lichen planus pemphigoides. ( 29537153 )
2018
31
Blastomycosis-like Pyoderma Arising in Lichen Planus. ( 29462233 )
2018
32
Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study. ( 29967591 )
2018
33
Dental Implants and Oral Lichen Planus. ( 29801195 )
2018
34
Alterations of Serum Lipid Profile Patterns in Oral Lichen Planus Patients: A Case-Control Study. ( 29962775 )
2018
35
An atypical clinical presentation of lichen planus pigmentosus with typical dermoscopic pattern. ( 29577239 )
2018
36
Time-resolved fluorescence spectroscopy for the diagnosis of oral lichen planus. ( 29436013 )
2018
37
Altered HMGB1 distribution in patients with lichen planus. ( 29888700 )
2018
38
LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus. ( 29335479 )
2018
39
Synchronous presentation of systemic lupus erythematosus and oral reticular lichen planus. ( 29387764 )
2018
40
Melanoma in situ mimicking a Lichen planus-like keratosis. ( 29350666 )
2018
41
Lichen planus: a rare cause of a narrowed esophagus. ( 29922754 )
2018
42
Association between TNFI+ - 308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis. ( 29641751 )
2018
43
Dermoscopy of lichen planus pigmentosus in Indian patients - Pitfalls to avoid. ( 29620038 )
2018
44
Salivary proteomics in lichen planus: A relationship with pathogenesis? ( 29383810 )
2018
45
Association between hepatitis C infection in Thai patients with oral lichen planus: A case-control study. ( 29345111 )
2018
46
Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma: A Diagnostic Conundrum. ( 29360655 )
2018
47
The importance of topical steroids after adhesiolysis in erosive lichen planus and graft versus host disease. ( 29884087 )
2018
48
Effectiveness of Oral Methotrexate Therapy versus Systemic Corticosteroid Therapy in Treatment of Generalised Lichen Planus. ( 29950252 )
2018
49
Detection of lichen planus pigmentosus with dermoscopy and reflectance confocal microscopy. ( 29790598 )
2018
50
Increased expression of p16 in both oral and genital lichen planus. ( 29924765 )
2018
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Variations for Lichen Planus

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Expression for Lichen Planus

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Search GEO for disease gene expression data for Lichen Planus.
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Pathways for Lichen Planus

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Pathways related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 64
Show member pathways
 13.35 CXCL9 CXCR3 IL4 ITGAL TLR9 TNF
2
Allograft rejection 1 37
Show member pathways
 12.74 CXCL9 GZMB ICAM1 IFNG IL4 ITGAL
3
Influenza A 37
Show member pathways
 12.55 ICAM1 IFNG IL4 MX1 TLR9 TNF
4
NF-kappaB Signaling 4
12.5 GZMB IFNG IL4 TLR9 TNF
5
HTLV-I infection 37
12.36 ICAM1 ITGAL TNF TP53
6
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.36 GZMB ICAM1 IFNG IL4 ITGAL TNF
7
Keratinization 66
Show member pathways
 12.3 DSG3 FLG IVL KRT10 KRT13 KRT16
8
IL-17 Family Signaling Pathways 65
Show member pathways
 12.28 DEFB4A IFNG IL4 TNF
9
Epstein-Barr virus infection 37
12.24 ICAM1 IFNG ITGAL TP53
10
Folate Metabolism 1
Show member pathways
 12.23 ICAM1 IFNG IL4 TNF TP53
11
Colorectal Cancer Metastasis 64
12.13 IFNG TLR9 TNF TP53
12
Bacterial infections in CF airways 22
Show member pathways
 12.05 DEFB4A IFNG IL4 TLR9 TNF
13
Fluid shear stress and atherosclerosis 37
12.03 ICAM1 IFNG TNF TP53
14
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.91 IFNG IL4 ITGAL TNF
15
Interleukin-4 and 13 signaling 66
11.89 ICAM1 IL4 TNF TP53
16
Rheumatoid arthritis 37
11.77 ICAM1 IFNG ITGAL TNF
17
Spinal Cord Injury 1
11.73 ICAM1 IFNG IL4 TNF TP53
18
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.71 IFNG IL4 TNF
19
Dendritic Cells Developmental Lineage Pathway 65
11.69 IFNG TLR9 TNF
20
Glucocorticoid receptor regulatory network 1
11.69 ICAM1 IFNG IL4 TP53
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.61 ICAM1 IFNG TNF
22
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.59 GZMB IFNG TNF
23
Staphylococcus aureus infection 37
11.55 ICAM1 ITGAL KRT10
24
Photodynamic therapy-induced AP-1 survival signaling. 1
11.5 IFNG TNF TP53
25
Interleukin-10 signaling 66
11.47 ICAM1 IL4 TNF
26
Immune response_Role of integrins in NK cells cytotoxicity 22
11.42 ICAM1 IFNG ITGAL
27
Type II interferon signaling (IFNG) 1
11.32 CXCL9 ICAM1 IFNG
28
CXCR3-mediated signaling events 1
11.27 CXCL9 CXCR3 ITGAL
29
Innate Lymphoid Cell Differentiation Pathways 65
11.26 CXCR3 GZMB IFNG IL4 TNF
30
Development and heterogeneity of the ILC family 1
11.24 IFNG IL4 TNF
31
Cytokines and Inflammatory Response 1
11.18 IFNG IL4 TNF
32
African trypanosomiasis 37
11 ICAM1 IFNG TLR9 TNF
33
Malaria 37
10.71 ICAM1 IFNG ITGAL TLR9 TNF
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GO Terms for Lichen Planus

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Cellular components related to Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 CXCL9 DEFB4A ICAM1 IFNG IL4 KRT10
2 external side of plasma membrane GO:0009897 9.62 CXCL9 CXCR3 ICAM1 TNF
3 intermediate filament GO:0005882 9.35 DST FLG KRT10 KRT13 KRT16
4 hemidesmosome GO:0030056 9.16 COL17A1 DST
5 cornified envelope GO:0001533 8.92 DSG3 FLG IVL KRT10

Biological processes related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CXCL9 DEFB4A IFNG IL4 TNF
2 regulation of immune response GO:0050776 9.81 COL17A1 ICAM1 IL4 ITGAL
3 defense response GO:0006952 9.76 CXCL9 DEFB4A MX1 TNF
4 inflammatory response GO:0006954 9.73 CXCL9 CXCR3 ITGAL KRT16 TLR9 TNF
5 peptide cross-linking GO:0018149 9.65 FLG IVL KRT10
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 ICAM1 IFNG TNF
7 keratinization GO:0031424 9.55 DSG3 IVL KRT10 KRT13 KRT16
8 T cell chemotaxis GO:0010818 9.54 CXCL9 CXCR3
9 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.49 ICAM1 TNF
10 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IFNG TNF
11 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.37 ICAM1 ITGAL
12 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
13 keratinocyte differentiation GO:0030216 9.26 FLG IVL KRT10 KRT16
14 cornification GO:0070268 9.1 DSG3 FLG IVL KRT10 KRT13 KRT16

Molecular functions related to Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL9 IFNG IL4 TNF
2 structural molecule activity GO:0005198 9.02 FLG IVL KRT10 KRT13 KRT16
3 protein binding GO:0005515 10.09 COL17A1 CXCL9 DEFB4A DST FLG GZMB
Sources

Sources for Lichen Planus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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