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MCID: LCH002
MIFTS: 54

Lichen Planus

Categories: Genetic diseases, Immune diseases, Infectious diseases, Oral diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lichen Planus

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MalaCards integrated aliases for Lichen Planus:

Name: Lichen Planus 12 73 36 54 44 15 17 70 32
Lichen, Ruber Planus 12
Lichen Ruber Planus 12

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases Genetic diseases
Anatomical: Skin diseases Oral diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9201
KEGG 36 H01654
ICD9CM 34 697.0
MeSH 44 D008010
NCIt 50 C3189
SNOMED-CT 67 156377007
ICD10 32 L43 L43.9
UMLS 70 C0023646
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Summaries for Lichen Planus

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KEGG : 36 Lichen planus (LP) is a chronic inflammatory and immune mediated skin disease with characteristic clinical and histopathologic features. The skin and oral mucosa are the most frequently involved areas. Other mucous membranes (including the genitalia, esophagus, and conjunctiva) and skin appendages (e.g., scalp hair and nails) can also be affected. The etiology and pathogenesis of LP remain unclear. An autoimmune reaction in which CD8+-T lymphocytes attack basal keratinocytes leading to apoptosis of the cells has been favored. Various potential triggers, e.g. viral or bacterial antigens, metal ions, drugs or physical factors, could initiate the autoimmune process. Nonetheless, the role of the individual trigger factors is controversial. There is a significant association between lichen planus and infection with hepatitis C virus (HCV). The diagnosis of LP is based on the clinical presentation and should be confirmed by biopsy, if suspected. Histopathology is often conclusive, but in vesiculobullous cutaneous LP or erosive oral LP, direct immunofluorescence (DIF) studies can be an integral step in differentiating between LP and other diseases. With few exceptions, all forms of LP are treated with the same measures. Depending on the severity of the findings, topical and systemic treatment options are available.

MalaCards based summary : Lichen Planus, also known as lichen, ruber planus, is related to lichen planus pemphigoides and pemphigoid, and has symptoms including pruritus An important gene associated with Lichen Planus is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Developmental Biology and Measles. The drugs Lycopene and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and t cells, and related phenotypes are Increased gamma-H2AX phosphorylation and digestive/alimentary

Disease Ontology : 12 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes.

Wikipedia : 73 Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails,... more...

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Related Diseases for Lichen Planus

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Diseases in the Lichen Planus family:

Lichen Planus, Familial Rare Lichen Planus

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 724)
# Related Disease Score Top Affiliating Genes
1 lichen planus pemphigoides 33.3 DST COL17A1
2 pemphigoid 31.8 TNF IFNG DST COL17A1
3 graft-versus-host disease 31.6 TNF IL6 IFNG GZMB
4 candidiasis 31.5 TNF IL6 IFNG DEFB4A
5 exanthem 31.4 TNF IL6 IFNG
6 stomatitis 31.4 TNF MX1 IL6 IFNG
7 leukoplakia 31.4 KRT13 KRT1 FLG DEFB4A
8 gingivitis 31.4 TNF IL6 IFNG DEFB4A
9 syphilis 31.3 TNF IL6 IFNG
10 herpes zoster 31.2 TNF IFNG COL17A1
11 esophagitis 31.2 TNF IL6 FLG
12 aphthous stomatitis 31.2 TNF IL6 IFNG
13 thyroiditis 31.2 TNF IL6 IFNG
14 viral hepatitis 31.2 TNF MX1 IL6 IFNG
15 ulcerative colitis 31.1 TNF IL6 IFNG ICAM1
16 erythema multiforme 31.1 TNF IL6 IFNG ICAM1 GZMB
17 keratoconjunctivitis 31.1 TNF IL6 IFNG ICAM1
18 periodontitis 31.1 TNF IL6 IFNG DEFB4A
19 chickenpox 31.1 TNF IL6 IFNG
20 hepatitis b 31.1 TNF MX1 IL6 IFNG
21 pemphigus 31.0 TNF IL6 DST DSG3 COL17A1
22 allergic disease 31.0 TNF IL6 IFNG CXCR3
23 cryoglobulinemia 31.0 TNF IL6 IFNG
24 vaginitis 30.9 TNF IL6 DEFB4A
25 autoimmune disease 30.9 TNF ITGAL IL6 IFNG DSG3 CXCR3
26 purpura 30.9 TNF IL6 IFNG
27 erythema nodosum 30.9 TNF IL6 IFNG ICAM1
28 proteasome-associated autoinflammatory syndrome 1 30.8 TNF IL6 IFNG ICAM1
29 paraneoplastic pemphigus 30.8 DST DSG3 COL17A1
30 conjunctivitis 30.8 TNF IL6 IFNG ICAM1 CXCL9
31 guttate psoriasis 30.8 ITGAL IFNG
32 sclerosing cholangitis 30.8 TNF IL6 ICAM1
33 hidradenitis 30.8 TNF KRT10 IFNG
34 linear iga disease 30.8 DST COL17A1
35 epidermolysis bullosa acquisita 30.7 LAMC2 DST COL17A1
36 cicatricial pemphigoid 30.7 LAMC2 DST COL17A1
37 crohn's disease 30.7 TNF IL6 IFNG ICAM1 DEFB4A
38 pericarditis 30.7 TNF IL6 IFNG
39 celiac disease 1 30.7 TNF IL6 IFNG GZMB CXCR3
40 bullous pemphigoid 30.7 TNF LAMC2 IVL DST DSG3 COL17A1
41 pemphigus vulgaris, familial 30.7 IVL DST DSG3 COL17A1
42 acne 30.6 TNF IL6 FLG DEFB4A
43 keratosis 30.6 KRT16 KRT10 KRT1 IVL FLG
44 hidradenitis suppurativa 30.6 TNF KRT10 IFNG
45 mumps 30.6 TNF MX1 IL6 IFNG
46 sarcoidosis 1 30.5 TNF IFNG ICAM1 CXCR3 CXCL9
47 cutaneous lupus erythematosus 30.5 TNF MX1 IL6 IFNG ICAM1 CXCR3
48 keratitis, hereditary 30.5 TNF KRT13 IL6 CXCL9
49 allergic contact dermatitis 30.5 TNF IL6 IFNG ICAM1 FLG DEFB4A
50 poliomyelitis 30.5 TNF IFNG ICAM1

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to Lichen Planus
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Symptoms & Phenotypes for Lichen Planus

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UMLS symptoms related to Lichen Planus:


pruritus

GenomeRNAi Phenotypes related to Lichen Planus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.32 COL17A1 CXCL9 CXCR3 DEFB4A DSG3 IVL

MGI Mouse Phenotypes related to Lichen Planus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.23 DSG3 ICAM1 IFNG IL6 KRT13 KRT16
Sources

Drugs & Therapeutics for Lichen Planus

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Drugs for Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lycopene Approved, Investigational Phase 4 502-65-8 446925
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Lactitol Approved, Investigational Phase 4 585-86-4 157355
8
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
9
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
10
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
11
Pomegranate Experimental, Investigational Phase 4
12
Chitosan Experimental Phase 4 9012-76-4 71853
13 Protective Agents Phase 4
14 Methylprednisolone Acetate Phase 4
15 Radiation-Protective Agents Phase 4
16 Sodium Channel Blockers Phase 4
17 Anti-Arrhythmia Agents Phase 4
18 Diuretics, Potassium Sparing Phase 4
19
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
20
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
21 Tomato Approved Phase 2, Phase 3
22
Fluoxymesterone Approved, Illicit Phase 2, Phase 3 76-43-7 6446
23
Nystatin Approved, Vet_approved Phase 2, Phase 3 1400-61-9 11953884
24
Clobetasol Approved, Experimental, Investigational Phase 2, Phase 3 25122-46-7, 25122-41-2 32798 5311051
25
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
26
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
27
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
28
Petrolatum Approved, Investigational Phase 3 8009-03-8
29
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030
30 Antioxidants Phase 2, Phase 3
31 Hormones Phase 2, Phase 3
32 glucocorticoids Phase 2, Phase 3
33 Hormone Antagonists Phase 2, Phase 3
34 Tea Phase 3
35 Cyclooxygenase Inhibitors Phase 2, Phase 3
36 Antifungal Agents Phase 3
37 Anti-Bacterial Agents Phase 3
38 Anti-Infective Agents Phase 3
39 Respiratory System Agents Phase 3
40 Anti-Asthmatic Agents Phase 3
41 Betamethasone benzoate Phase 3
42 Betamethasone-17,21-dipropionate Phase 3
43 Betamethasone sodium phosphate Phase 3
44 Betamethasone Valerate Phase 3 2152-44-5
45 Antibiotics, Antitubercular Phase 3
46
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795 449171
47
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492 6473866
48
Licorice Approved Phase 2
49
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
50
Metronidazole Approved Phase 2 443-48-1 4173

Interventional clinical trials:

(show top 50) (show all 110)
# Name Status NCT ID Phase Drugs
1 Management of Pain in Oral Lichen Planus Patients: A Comparative Pilot Study Completed NCT03572959 Phase 4 0.1 % topical triamcinolone acetonide
2 Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus: A Randomized, Double Blind Clinical Trial Completed NCT02587117 Phase 4 lycopene;Prednisolone
3 A Comparative Clinical and Immunohistochemical Study Between Topical Pimecrolimus and Corticosteroid in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
4 Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus (A Randomized Clinical Trial) Completed NCT04193748 Phase 4 Topical pomegranate seeds and peel extracts
5 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus: A Pilot, Randomized, Clinical and Immunohistochemical Trial Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
6 The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial Completed NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
7 Comparative Evaluation of Effect of Oral Zinc Supplementation and Placebo as an Adjuvant to Topical Corticosteroid Therapy in Oral Lichen Planus Patients Recruiting NCT04278599 Phase 4 Oral Zinc supplementation;Oral placebo supplementation
8 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus. A Randomized Controlled Trial Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
9 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treatment Oral LichenPlanus Completed NCT02421770 Phase 3
10 Use of Topical Non-Steroidal Anti- Inflammatory to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Completed NCT03509675 Phase 2, Phase 3 Ibuprofen suspension 5mg/100ml;Placebos
11 Evaluation of Systemic Administration of Green Tea Polyphenols as a Supportive Antioxidant Agent in the Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
12 Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus (A Randomized Clinical Trial) Completed NCT04652739 Phase 2, Phase 3 Lycopene Softgel, 10 Mg;Prednisolone
13 Randomized Placebo-Controlled Clinical Pilot Trial Regarding the Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
14 A Study of Topical Hexaminolevulinate (HAL) Photodynamic Therapy (PDT) and a Phase III Comparative Treatment Study of HAL PDT in Female Genital Erosive Lichen Planus (GELP) Completed NCT01282515 Phase 2, Phase 3 clobetasol propionate 0,05% ointment;hexaminolevulinate
15 Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus. A Multicenter Placebo-controlled Randomized Clinical Trial. Recruiting NCT04364555 Phase 2, Phase 3 Clobetasol Propionate;Placebo/active;Placebo/placebo
16 Efficacy of Topical Rapamycin in Treatment of Chronic Erosive Oral Lichen Planus. Double Blind Randomised Controlled Trial Rapamycin vs Topical Steroids Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
17 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
18 A Comparative Study on Clinical Efficacy of Clobetasol and Betamethasone in Orabase in Combination With Clotrimazole, in Oral Lichen Planus Unknown status NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
19 Efficacy of Intralesional Injection of Autologous Platelet Rich Plasma Versus Intralesional Injection of Corticosteroids on Pain Relief and Ulcers Healing in Patients With Erosive Oral Lichen Planus; Randomized Clinical Trial Unknown status NCT03293368 Phase 2 Triamcinolone Acetonide
20 Single-Center, Prospective, Open Label, Single-arm Pilot Study Investigating the Efficacy and Safety of Alitretinoin in Patients Suffering From Severe Mucosal Lichen Planus. Unknown status NCT01538732 Phase 2 alitretinoin
21 An Open-Label Pilot Study to Evaluate the Safety and Efficacy of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus Unknown status NCT01041625 Phase 2 Apremilast (CC-10004)
22 A Randomized, Double-blind, Placebo-controlled, Parallel Group Clinical Study to Assess the Safety and Efficacy of Three Doses of Clobetasol Propionate When Administered Intra-orally Twice Daily in Patients With Oral Lichen Planus (OLP) Using Rivelin®-CLO Patches Completed NCT03592342 Phase 2 Clobetasol Propionate
23 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on the Duration and Symptoms of Lesions That Caused by Symptomatic Oral Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
24 Treatment of Oral Lichen Planus Lesions Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
25 Efficacy of Oral Lycopene in the Management of Oral Lichen Planus Completed NCT00656214 Phase 2 Lycopene;Placebo
26 A Randomized, Placebo-Controlled, Double-Blind Trial of a Two Week Course of Curcuminoids in Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
27 Effect of the Probiotic Bifidobacterium Animalis Subsp. Lactis HN019 on Clinical, Histopathological and Immunophenotypic Features of Oral Lichen Planus Completed NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
28 Dexamethasone Solution and Dexamethasone in Mucoloxâ„¢ for the Treatment of Oral Lichen Planus Completed NCT02850601 Phase 2 Dexamethasone
29 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus- A Double-blinded Randomized Clinical Trial in Sri Lanka Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
30 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
31 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus and Improvement of Quality of Life: A Randomized, Double Blind, Controlled Study Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
32 A 6-week Randomized, Double-blind, Vehicle-controlled Pilot Study With a 6-week Open Label Extension to Assess the Efficacy and Safety of Pimecrolimus 1% Cream in the Treatment of Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
33 Dexamethasone 0.01% Solution for the Treatment of Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
34 Cedar Honey in Treatment of Oral Lichen Planus: a Randomized Clinical Trial Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
35 Nonaromatic Naphthalan - Composition Study and Biological Effects on Epithelial Tissues Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
36 Hydroxychloroquine Versus Clobetasol 0.05% Rinse for the Treatment of Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
37 INCB018424 in the Treatment of Cutaneous Lichen Planus Completed NCT03697460 Phase 2 INCB018424
38 Valchlor in the Treatment of Lichen Planopilaris: A Single Arm, Open- Label, Exploratory Study Completed NCT03417141 Phase 2 Mechlorethamine 0.016% Top Gel
39 KPL-716-C202: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Pilot Study to Investigate the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Diseases Characterized by Chronic Pruritus Completed NCT03858634 Phase 2 KPL-716;Placebo
40 A Proof of Concept Study to Evaluate the Efficacy, Safety and Tolerability of Secukinumab 300 mg Over 32 Weeks in Adult Patients With Biopsy-proven Forms of Lichen Planus Not Adequately Controlled With Topical Therapies - PRELUDE Recruiting NCT04300296 Phase 2 Cutaneous lichen planus secukinumab 300 mg Q4W;Cutaneous lichen planus placebo;Mucosal lichen planus placebo;Lichen planopilaris placebo;Mucosal lichen planus secukinumab 300 mg Q4W;Lichen planopilaris secukinumab 300 mg Q4W
41 Dexamethasone Solution and Dexamethasone in Mucoloxâ„¢ for the Treatment of Oral Inflammatory Ulcerative Diseases Recruiting NCT04540133 Phase 2 dexamethasone 0.5mg/5ml solution;dexamethasone 0.5mg/5ml solution in Mucoloxâ„¢
42 The AP-GELP Study: A Randomized, Placebo-Controlled Clinical Trial on the Effects of Phosphodiesterase 4-Inhibitor Apremilast in Female Genital Erosive Lichen Planus Recruiting NCT03656666 Phase 2 Apremilast;Placebo
43 Oral Low-Dose Naltrexone in the Treatment of Lichen Planopilaris and Frontal Fibrosing Alopecia; an Uncontrolled Open-label Prospective Study Active, not recruiting NCT04409041 Phase 2 Low-Dose Naltrexone
44 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
45 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Oral Mucosal Pain in Burning Mouth Syndrome, Sjögrens Syndrome and Lichen Planus. Terminated NCT01584947 Phase 2 Bupivacaine;Placebo
46 Phase 2 Study of the Treatment of Oral Erosive Lichen Planus With 1% Pimecrolimus Cream: a Double Blind Randomized Prospective Trial With Measurement of Pimecrolimus Levels in the Blood Terminated NCT00321750 Phase 2 1% pimecrolimus cream
47 A Double-Blind, Randomized, Multicenter Pilot Study to Evaluate the Efficacy and Safety of Etanercept 50mg SC Twice Weekly in the Treatment of Moderate to Severe Lichen Planus Terminated NCT00285779 Phase 2 Etanercept;Placebo
48 A Randomized, Double-Blind, Placebo-Controlled Pilot Study of the Efficacy and Safety of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus Terminated NCT00135733 Phase 2 Amevive (Alefacept);Placebo
49 The APOLP Trial: A Single-Center, Randomized, 16 Weeks, Explanatory, Parallel-Group, Superiority, Blinded, Placebo-Controlled, Clinical Trial of Apremilast Use in Oral Lichen Planus Withdrawn NCT03836885 Phase 2 Apremilast;Placebo
50 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1 placebo;Quercetin

Search NIH Clinical Center for Lichen Planus

Cochrane evidence based reviews: lichen planus

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Genetic Tests for Lichen Planus

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Anatomical Context for Lichen Planus

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The Foundational Model of Anatomy Ontology organs/tissues related to Lichen Planus:

19
Skin, Tongue

MalaCards organs/tissues related to Lichen Planus:

40
Tongue, Skin, T Cells, Lung, Bone Marrow, Liver, Endothelial
Sources

Publications for Lichen Planus

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Articles related to Lichen Planus:

(show top 50) (show all 7966)
# Title Authors PMID Year
1
T cells reactive with the NC16A domain of BP180 are present in vulval lichen sclerosus and lichen planus. 61 54
19686329 2010
2
Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus. 54 61
18331568 2008
3
The expression of TNF-alpha and ICAM-1 in lesions of lichen planus and its implication. 61 54
18231758 2007
4
Cytokine alterations in lichen sclerosus: an immunohistochemical study. 54 61
17034521 2006
5
Collagen XVII/BP180: a collagenous transmembrane protein and component of the dermoepidermal anchoring complex. 61 54
16197389 2005
6
Cytotoxic molecule expression and epithelial cell apoptosis in oral and cutaneous lichen planus. 54 61
15151217 2004
7
Lichen planus and leukocytoclastic vasculitis induced by interferon alpha-2b in a subject with HCV-related chronic active hepatitis. 54 61
12705750 2003
8
Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses: CD1a+, factor XIIIa+, and CD68+ cells in eczematous dermatitis, psoriasis, lichen planus and graft-versus-host disease. 54 61
12373334 2002
9
Oral lichen planus: an update. 54 61
12582419 2002
10
Topical retinaldehyde treatment in oral lichen planus and leukoplakia. 54 61
12779246 2002
11
Upregulation of human beta-defensin 2 peptide expression in oral lichen planus, leukoplakia and candidiasis. an immunohistochemical study. 61 54
12389997 2002
12
Identification of the AgNORs, PCNA and ck16 proteins in oral lichen planus lesions. 61 54
11834097 2001
13
Presence of lichen planus during a course of interferon alpha-2a therapy for a viral chronic C hepatitis. 54 61
11694869 2001
14
Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation. 61 54
11523046 2001
15
Lichen planus exacerbation by interferon-alpha-2A for chronic viral hepatitis C. 61 54
19864712 2000
16
Lichenoid dermatitis in paraneoplastic pemphigus: a pathogenic trigger of epitope spreading? 61 54
10815859 2000
17
Lichen planus induced by interferon-alpha-2B therapy in a patient with cutaneous malignant melanoma. 54 61
10494726 1999
18
Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180. 61 54
10417629 1999
19
Acquired skin disease of hemidesmosomes. 61 54
10379705 1999
20
Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). 54 61
10233762 1999
21
BP180/type XVII collagen: its role in acquired and inherited disorders or the dermal-epidermal junction. 54 61
10335914 1999
22
C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. 61 54
10027407 1999
23
MIG is a dominant lymphocyte-attractant chemokine in lichen planus lesions. 61 54
9856808 1998
24
Keratin and involucrin expression in discoid lupus erythematosus and lichen planus. 61 54
9341972 1997
25
The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus. 54 61
9341973 1997
26
Altered distribution and synthesis of laminin-5 (kalinin) in oral lichen planus, epithelial dysplasias and squamous cell carcinomas. 61 54
9115910 1997
27
Lichen planus and chronic hepatitis C: exacerbation of the lichen under interferon-alpha-2a therapy. 54 61
8864684 1996
28
Vascular adhesion molecules in oral lichen planus. 54 61
8784900 1996
29
In three types of interface dermatitis, different patterns of expression of intercellular adhesion molecule-1 (ICAM-1) indicate different triggers of disease. 54 61
7616001 1995
30
Destruction of the epithelial anchoring system in lichen planus. 54 61
7615961 1995
31
Lichen planus induced by interferon-alpha-2a therapy for chronic active hepatitis C. 61 54
7600144 1995
32
Alteration of cytokeratin expression in oral lichen planus. 54 61
7542150 1995
33
Expression of MxA protein in inflammatory dermatoses. 61 54
7822763 1995
34
Analysis of mast cell subpopulations (MCT, MCTC) in cutaneous inflammation using novel enzyme-histochemical staining techniques. 54 61
7538409 1994
35
Immunofluorescent analysis of the basement membrane zone in lichen planus suggests destruction of the lamina lucida in bullous lesions. 54 61
8040461 1994
36
Increased submucosal factor XIIIa-positive dendrocytes in oral lichen planus. 61 54
7517451 1994
37
Lymphocyte and macrophage subsets in active and inactive lesions of lichen planus. 61 54
8100122 1993
38
Epidermal dendritic cells in psoriasis possess a phenotype associated with antigen presentation: in situ expression of beta 2-integrins. 54 61
1401271 1992
39
Expression of the CD54 (ICAM-1) and CD11a (LFA-1) adhesion molecules in oral mucosal inflammation. 54 61
1348286 1992
40
Elastolysis in lichen ruber planus. 54 61
1681662 1991
41
Cytokine modulation of adhesion molecules in the regulation of immunologic cytotoxicity of epidermal targets. 61 54
2258627 1990
42
[Lichen planus: etiopathogenesis]. 54 61
1983174 1990
43
Induction and upregulation of adhesion receptors in oral and dermal lichen planus. 54 61
1981078 1990
44
Lichen planus pemphigoides: case report and results of immunofluorescence and immunoelectron microscopic study. 61 54
2180994 1990
45
Immunohistochemical studies on fibrillin in amyloidosis, lichen ruber planus and porphyria. 61 54
1699374 1990
46
Etretinate suppresses ICAM-1 expression by lesional keratinocytes in healing cutaneous lichen planus. 54 61
1979727 1990
47
The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo. 61
33190330 2021
48
Posttraumatic Stress Disorder and the Associated Risk of Autoimmune Skin Diseases: A Nationwide Population-Based Cohort Study. 61
33587564 2021
49
Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis. 61
31994293 2021
50
Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis. 61
32144837 2021
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Variations for Lichen Planus

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Expression for Lichen Planus

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Search GEO for disease gene expression data for Lichen Planus.
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Pathways for Lichen Planus

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Pathways related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Developmental Biology 65
Show member pathways
 13.45 TNF KRT16 KRT13 KRT10 KRT1 IVL
2
Measles 36
Show member pathways
 12.71 TNF MX1 ITGAL IL6 IFNG ICAM1
3
Degradation of the extracellular matrix 65
Show member pathways
 12.7 LAMC2 ITGAL ICAM1 DST COL17A1
4
Allograft rejection 36 1
Show member pathways
 12.65 TNF ITGAL IL6 IFNG ICAM1 GZMB
5
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.45 TNF ITGAL IFNG ICAM1 GZMB
6
Human T-cell leukemia virus 1 infection 36
12.3 TNF ITGAL IL6 ICAM1
7
Selenium Micronutrient Network 1
Show member pathways
 12.29 TNF IL6 IFNG ICAM1
8
IL-17 Family Signaling Pathways 64
Show member pathways
 12.29 TNF IL6 IFNG DEFB4A
9
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.29 TNF IL6 CXCR3 CXCL9
10
Keratinization 65
Show member pathways
 12.15 KRT16 KRT13 KRT10 KRT1 IVL FLG
11
Bacterial infections in CF airways 23
Show member pathways
 12.14 TNF IL6 IFNG DEFB4A
12
Spinal Cord Injury 1
11.93 TNF IL6 IFNG ICAM1
13
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.9 TNF ITGAL IL6 IFNG
14
Cytoskeleton remodeling Neurofilaments 23
Show member pathways
 11.83 KRT16 KRT13 KRT1 DST
15
Amoebiasis 36
11.79 TNF LAMC2 IL6 IFNG
16
Glucocorticoid receptor regulatory network 1
11.76 IL6 IFNG ICAM1
17
Th1 Differentiation Pathway 64
Show member pathways
 11.73 TNF IL6 IFNG
18
Dendritic Cells Developmental Lineage Pathway 64
11.71 TNF IL6 IFNG
19
Innate Lymphoid Cell Differentiation Pathways 64
11.66 TNF IFNG GZMB CXCR3
20
Rheumatoid arthritis 36
11.62 TNF ITGAL IL6 IFNG ICAM1
21
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.6 TNF IFNG GZMB
22
IgA-Producing B Cells in the Intestine 64
11.55 TNF ITGAL IL6 ICAM1
23
Photodynamic therapy-induced AP-1 survival signaling. 1
11.52 TNF IL6 IFNG
24
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.5 TNF IL6 IFNG ICAM1
25
Interleukin-10 signaling 65
11.49 TNF IL6 ICAM1
26
amb2 Integrin signaling 1
11.47 TNF IL6 ICAM1
27
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.44 TNF IL6 IFNG
28
Immune response_Role of integrins in NK cells cytotoxicity 23
11.42 ITGAL IFNG ICAM1
29
Type II interferon signaling (IFNG) 1
11.34 IFNG ICAM1 CXCL9
30
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.32 TNF IFNG GZMB
31
CXCR3-mediated signaling events 1
11.27 ITGAL CXCR3 CXCL9
32
Development and heterogeneity of the ILC family 1
11.24 TNF IL6 IFNG
33
African trypanosomiasis 36
11.19 TNF IL6 IFNG ICAM1
34
Cytokines and Inflammatory Response 1
11.15 TNF IL6 IFNG
35
Staphylococcus aureus infection 36
11.08 KRT16 KRT13 KRT10 ITGAL ICAM1 DEFB4A
36
Malaria 36
11.05 TNF ITGAL IL6 IFNG ICAM1
37
G-protein signaling_Rap2B regulation pathway 23
10.96 TNF LAMC2 ITGAL IL6 CXCL9 COL17A1
Sources

GO Terms for Lichen Planus

About this section

Cellular components related to Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 TNF LAMC2 KRT10 KRT1 IL6 IFNG
2 extracellular space GO:0005615 9.85 TNF LAMC2 KRT10 KRT1 IL6 IFNG
3 collagen-containing extracellular matrix GO:0062023 9.72 LAMC2 KRT1 ICAM1 FLG COL17A1
4 intermediate filament GO:0005882 9.43 KRT16 KRT13 KRT10 KRT1 FLG DST
5 hemidesmosome GO:0030056 9.37 DST COL17A1
6 cornified envelope GO:0001533 9.02 KRT10 KRT1 IVL FLG DSG3

Biological processes related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.05 LAMC2 ITGAL ICAM1 DST DSG3 CXCR3
2 immune response GO:0006955 9.99 TNF IL6 IFNG DEFB4A CXCR3 CXCL9
3 defense response to virus GO:0051607 9.91 MX1 IL6 IFNG CXCL9
4 extracellular matrix organization GO:0030198 9.89 TNF LAMC2 ITGAL ICAM1 COL17A1
5 cellular response to lipopolysaccharide GO:0071222 9.88 TNF IL6 ICAM1 CXCL9
6 inflammatory response GO:0006954 9.88 TNF KRT16 ITGAL IL6 CXCR3 CXCL9
7 defense response GO:0006952 9.87 TNF MX1 DEFB4A CXCL9
8 regulation of insulin secretion GO:0050796 9.8 TNF IL6 IFNG
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 TNF IL6 IFNG
10 humoral immune response GO:0006959 9.77 TNF IL6 IFNG
11 positive regulation of interleukin-1 beta production GO:0032731 9.77 TNF IL6 IFNG
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 TNF IFNG ICAM1
13 positive regulation of chemokine production GO:0032722 9.71 TNF IL6 IFNG
14 positive regulation of neuroinflammatory response GO:0150078 9.64 TNF IL6
15 negative regulation of amyloid-beta clearance GO:1900222 9.63 TNF IFNG
16 negative regulation of lipid storage GO:0010888 9.62 TNF IL6
17 keratinocyte differentiation GO:0030216 9.62 KRT16 KRT10 IVL FLG
18 vascular endothelial growth factor production GO:0010573 9.61 TNF IL6
19 establishment of skin barrier GO:0061436 9.61 KRT16 KRT1 FLG
20 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.55 ITGAL ICAM1
21 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 TNF IL6 ICAM1
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IFNG
23 positive regulation of vitamin D biosynthetic process GO:0060557 9.48 TNF IFNG
24 positive regulation of nitrogen compound metabolic process GO:0051173 9.46 TNF IFNG
25 peptide cross-linking GO:0018149 9.46 KRT10 KRT1 IVL FLG
26 hemidesmosome assembly GO:0031581 9.43 LAMC2 DST COL17A1
27 keratinization GO:0031424 9.43 KRT16 KRT13 KRT10 KRT1 IVL DSG3
28 cornification GO:0070268 9.17 KRT16 KRT13 KRT10 KRT1 IVL FLG

Molecular functions related to Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNF IL6 IFNG CXCL9
2 structural molecule activity GO:0005198 9.35 KRT16 KRT13 KRT10 FLG DST
3 structural constituent of epidermis GO:0030280 8.8 KRT10 KRT1 FLG
Sources

Sources for Lichen Planus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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