Lichen Planus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LCH002 MIFTS: 54	Lichen Planus Categories: Genetic diseases, Immune diseases, Oral diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Lichen Planus

MalaCards integrated aliases for Lichen Planus:

Name: Lichen Planus ¹¹ ⁷⁵ ⁵³ ⁴³ ¹⁴ ¹⁶ ⁷¹ ³¹ ³³

Lichen Ruber Planus ¹¹ ³³

Lichen Planus of Wilson ³³

Lichen, Ruber Planus ¹¹

Lp - [lichen Planus] ³³

Wilson Lichen Ruber ³³

Ruber Planus ³³

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Skin diseases Oral diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the skin and subcutaneous tissue

Papulosquamous disorders

Lichen planus

Lichen planus, unspecified

ICD11: ³³

Diseases of the skin

Inflammatory dermatoses

Papulosquamous dermatoses

Lichen planus

Lichen planus of unspecified type

Other specified lichen planus

External Ids:

Disease Ontology ¹¹ DOID:9201

ICD9CM ³⁴ 697.0

MeSH ⁴³ D008010

NCIt ⁴⁹ C3189

SNOMED-CT ⁶⁸ 156377007

ICD10 ³¹ L43 L43.9

EFO ¹⁶ EFO_1000726

ICD11 ³³ 1402978031 1402978031/other 1402978031/unspecified

UMLS ⁷¹ C0023646

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Summaries for Lichen Planus

Disease Ontology: ¹¹ A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes.

MalaCards based summary: Lichen Planus, also known as lichen ruber planus, is related to alopecia and stomatitis, and has symptoms including pruritus An important gene associated with Lichen Planus is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Extracellular matrix organization and COPI-independent Golgi-to-ER retrograde traffic. The drugs Triamcinolone and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and thyroid, and related phenotypes are Increased gamma-H2AX phosphorylation and growth/size/body region

Wikipedia: ⁷⁵ Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails,... more...

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Related Diseases for Lichen Planus

Diseases in the Lichen Planus family:

Lichen Planus, Familial

Rare Lichen Planus

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 759)

#	Related Disease	Score	Top Affiliating Genes
1	alopecia	31.7	TNF IFNG FLG COL17A1
2	stomatitis	31.5	TNF MX1 IFNG
3	pemphigoid	31.5	TNF IFNG DST DSG3 COL17A1
4	leukoplakia	31.5	KRT13 KRT1 FLG DEFB4A
5	candidiasis	31.4	TNF IFNG DEFB4A
6	gingivitis	31.4	TNF IFNG ICAM1 DEFB4A
7	viral infectious disease	31.4	TNF MX1 IFNG ICAM1 GZMB CXCR3
8	pemphigus	31.3	TNF DST DSG3 COL17A1
9	autoimmune disease	31.2	TNF ITGAL IFNG ICAM1 DSG3 CXCR3
10	lip and oral cavity cancer	31.2	MIR31 KRT13 IVL
11	erythema multiforme	31.1	TNF IFNG ICAM1 GZMB
12	periodontitis	31.1	TNF IFNG ICAM1 DEFB4A
13	aphthous stomatitis	31.1	TNF IFNG DSG3
14	bullous pemphigoid	31.1	TNF LAMC2 IVL DST DSG3 COL17A1
15	viral hepatitis	31.0	MX1 ITGAL IFNG ICAM1
16	fungal infectious disease	31.0	TNF IFNG DEFB4A
17	paraneoplastic pemphigus	31.0	DST DSG3 COL17A1
18	hashimoto thyroiditis	31.0	ITGAL IFNG ICAM1 CXCR3
19	keratoconjunctivitis	31.0	TNF ITGAL IFNG ICAM1
20	conjunctivitis	30.9	TNF IFNG ICAM1 CXCL9
21	metal allergy	30.9	TNF FLG
22	pemphigus vulgaris, familial	30.9	IVL DST DSG3 COL17A1
23	allergic disease	30.9	TNF IFNG ICAM1 GZMB FLG
24	acute graft versus host disease	30.9	TNF IFNG
25	erythema nodosum	30.9	TNF IFNG ICAM1
26	severe cutaneous adverse reaction	30.9	TNF KRT13 IFNG GZMB
27	celiac disease 1	30.8	TNF IFNG GZMB CXCR3
28	proteasome-associated autoinflammatory syndrome 1	30.8	TNF IFNG ICAM1
29	scabies	30.8	FLG DST COL17A1
30	seborrheic dermatitis	30.8	TNF FLG DEFB4A
31	cicatricial pemphigoid	30.8	LAMC2 KRT13 DST DSG3 COL17A1
32	cryoglobulinemia	30.7	TNF IFNG CXCL9
33	hidradenitis suppurativa	30.7	TNF KRT10 IFNG
34	epidermolysis bullosa acquisita	30.7	LAMC2 DST COL17A1
35	hidradenitis	30.7	TNF IFNG DSG3
36	actinic keratosis	30.6	TNF KRT10 IVL FLG
37	acne	30.6	TNF FLG DEFB4A
38	sarcoidosis 1	30.6	TNF IFNG ICAM1 CXCR3 CXCL9
39	pemphigoid gestationis	30.6	DST DSG3 COL17A1
40	pustular psoriasis	30.6	TNF IFNG CXCL9
41	papilloma	30.5	KRT13 KRT10 KRT1 IVL FLG
42	food allergy	30.5	TNF IFNG FLG
43	mumps	30.5	TNF MX1 IFNG
44	nevus, epidermal	30.5	KRT10 KRT1 IVL
45	severe acute respiratory syndrome	30.5	TNF MX1 IFNG CXCL9
46	keratosis	30.4	KRT16 KRT10 KRT1 IVL FLG DST
47	poliomyelitis	30.4	TNF IFNG ICAM1
48	skin sarcoidosis	30.4	TNF IFNG
49	folliculitis	30.4	TNF IFNG DEFB4A
50	dermatitis, atopic	30.4	TNF IVL IFNG ICAM1 FLG DEFB4A

Graphical network of the top 20 diseases related to Lichen Planus:

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Symptoms & Phenotypes for Lichen Planus

UMLS symptoms related to Lichen Planus:

pruritus

GenomeRNAi Phenotypes related to Lichen Planus according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased gamma-H2AX phosphorylation	GR00053-A	9.32	COL17A1 CXCL9 CXCR3 DEFB4A DSG3 IVL

MGI Mouse Phenotypes related to Lichen Planus:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.22	COL17A1 DSG3 DST ICAM1 IFNG IVL
2	immune system	MP:0005387	10.13	COL17A1 CXCL9 CXCR3 DEFB4A DSG3 DST
3	neoplasm	MP:0002006	10.03	CXCR3 GZMB ICAM1 IFNG ITGAL KRT10
4	digestive/alimentary	MP:0005381	9.97	DSG3 DST ICAM1 IFNG KRT13 KRT16
5	hematopoietic system	MP:0005397	9.97	COL17A1 CXCL9 CXCR3 DEFB4A DSG3 DST
6	craniofacial	MP:0005382	9.92	DSG3 DST IFNG KRT10 KRT13 KRT16
7	mortality/aging	MP:0010768	9.83	COL17A1 CXCL9 CXCR3 DSG3 DST GZMB
8	integument	MP:0010771	9.36	COL17A1 DSG3 DST ICAM1 IFNG KRT1

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Drugs & Therapeutics for Lichen Planus

Drugs for Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Triamcinolone

Approved, Vet_approved

Phase 4

124-94-7

31307

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Tannic acid

Approved

Phase 4

1401-55-4

16129878 16129778

Betamethasone

Approved, Vet_approved

Phase 4

378-44-9

9782

Miconazole

Approved, Investigational, Vet_approved

Phase 4

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

Phase 4

23593-75-1

2812

Lycopene

Approved, Investigational

Phase 4

502-65-8

446925

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Lactitol

Approved, Investigational

Phase 4

585-86-4

157355

Glucosamine

Approved, Investigational

Phase 4

3416-24-8

318324 439213

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Pomegranate

Experimental, Investigational

Phase 4

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Chitosan low molecular weight (20-200 mpa.s)

Experimental

Phase 4

14257-69-3, 9012-76-4

441477 71853

Antioxidants

Phase 4

Protective Agents

Phase 4

Triamcinolone hexacetonide

Phase 4

Triamcinolone diacetate

Phase 4

Triamcinolone Acetonide

Phase 4

6436

Hormones

Phase 4

Hormone Antagonists

Phase 4

glucocorticoids

Phase 4

Anti-Asthmatic Agents

Phase 4

Betamethasone-17,21-dipropionate

Phase 4

Betamethasone Valerate

Phase 4

2152-44-5

Betamethasone sodium phosphate

Phase 4

Betamethasone benzoate

Phase 4

Respiratory System Agents

Phase 4

Radiation-Protective Agents

Phase 4

Antifungal Agents

Phase 4

Methylprednisolone Acetate

Phase 4

584547

Anesthetics

Phase 4

Anesthetics, Local

Phase 4

Anti-Arrhythmia Agents

Phase 4

Sodium Channel Blockers

Phase 4

Diuretics, Potassium Sparing

Phase 4

Minocycline

Approved, Investigational

Phase 3

10118-90-8, 13614-98-7

54675783 5281021

Tomato

Approved

Phase 2, Phase 3

Ibuprofen

Approved

Phase 2, Phase 3

15687-27-1

3672

Fluoxymesterone

Approved, Illicit

Phase 2, Phase 3

76-43-7

6446

Clobetasol

Approved, Experimental, Investigational

Phase 2, Phase 3

25122-46-7, 25122-41-2

2791 5311051 32798

Nystatin

Approved, Vet_approved

Phase 2, Phase 3

1400-61-9

11953884

Sirolimus

Approved, Investigational

Phase 3

53123-88-9

5284616 6436030

Petrolatum

Approved, Investigational

Phase 3

8009-03-8

Anti-Inflammatory Agents

Phase 2, Phase 3

Tea

Phase 3

Interventional clinical trials:

(show top 50) (show all 125)

#	Name	Status	NCT ID	Phase	Drugs
1	Comparative Evaluation of Effect of Oral Zinc Supplementation and Placebo as an Adjuvant to Topical Corticosteroid Therapy in Oral Lichen Planus Patients	Unknown status	NCT04278599	Phase 4	Oral Zinc supplementation;Oral placebo supplementation
2	Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus (A Randomized Clinical Trial)	Completed	NCT04193748	Phase 4	Topical pomegranate seeds and peel extracts
3	Comparative Study of the Efficacy of Lycopene Versus Prednisolone in the Management of Oral Lichen Planus: A Randomized, Double Blind Clinical Trial	Completed	NCT02587117	Phase 4	lycopene;Prednisolone
4	Evaluation of Mucoadhesive Tacrolimus Patch on Caspase-3 Inducing Apoptosis in Oral Lichen Planus ( A Randomized Controlled Clinical Trial With Immunohistochemical Analysis)	Completed	NCT05139667	Phase 4	Corticosteroid Topical
5	Management of Pain in Oral Lichen Planus Patients: A Comparative Pilot Study	Completed	NCT03572959	Phase 4	0.1 % topical triamcinolone acetonide
6	A Comparative Clinical and Immunohistochemical Study Between Topical Pimecrolimus and Corticosteroid in Treatment of Oral Lichen Planus	Completed	NCT02443311	Phase 4	Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
7	Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus: A Pilot, Randomized, Clinical and Immunohistochemical Trial	Completed	NCT02858297	Phase 4	Glucosamine sulfate;triamcinolone acetonide
8	The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial	Completed	NCT03630198	Phase 4	Corticosteroid with lidocaine;Corticosteroid with normal saline
9	The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus. A Randomized Controlled Trial	Unknown status	NCT01083420	Phase 3	Minocycline;Dexamethasone
10	Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus (A Randomized Clinical Trial)	Completed	NCT04652739	Phase 2, Phase 3	Lycopene Softgel, 10 Mg;Prednisolone
11	Randomized Placebo-Controlled Clinical Pilot Trial Regarding the Efficacy of Elidel Cream on Erosive Oral Lichen Planus	Completed	NCT00130572	Phase 3	Pimecrolimus
12	Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treatment Oral LichenPlanus	Completed	NCT02421770	Phase 3
13	Evaluation of Systemic Administration of Green Tea Polyphenols as a Supportive Antioxidant Agent in the Management of Oral Lichen Planus	Completed	NCT02329600	Phase 3	green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
14	Use of Topical Non-Steroidal Anti- Inflammatory to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions.	Completed	NCT03509675	Phase 2, Phase 3	Ibuprofen suspension 5mg/100ml;Placebos
15	A Study of Topical Hexaminolevulinate (HAL) Photodynamic Therapy (PDT) and a Phase III Comparative Treatment Study of HAL PDT in Female Genital Erosive Lichen Planus (GELP)	Completed	NCT01282515	Phase 2, Phase 3	clobetasol propionate 0,05% ointment;hexaminolevulinate
16	Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus. A Multicenter Placebo-controlled Randomized Clinical Trial.	Recruiting	NCT04364555	Phase 2, Phase 3	Clobetasol Propionate;Placebo/Klobetasol APL oral gel 0.025%;Placebo
17	Efficacy of Topical Rapamycin in Treatment of Chronic Erosive Oral Lichen Planus. Double Blind Randomised Controlled Trial Rapamycin vs Topical Steroids	Terminated	NCT01061853	Phase 3	TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
18	Efficacy of Intralesional Injection of Autologous Platelet Rich Plasma Versus Intralesional Injection of Corticosteroids on Pain Relief and Ulcers Healing in Patients With Erosive Oral Lichen Planus; Randomized Clinical Trial	Unknown status	NCT03293368	Phase 2	Triamcinolone Acetonide
19	A Comparative Study on Clinical Efficacy of Clobetasol and Betamethasone in Orabase in Combination With Clotrimazole, in Oral Lichen Planus	Unknown status	NCT03026478	Phase 2	Betamethasone Dipropionate;Clobetasol Propionate
20	A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus	Unknown status	NCT01524744	Phase 2	Pimecrolimus ointment;Adcortyl
21	An Open-Label Pilot Study to Evaluate the Safety and Efficacy of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus	Unknown status	NCT01041625	Phase 2	Apremilast (CC-10004)
22	Single-Center, Prospective, Open Label, Single-arm Pilot Study Investigating the Efficacy and Safety of Alitretinoin in Patients Suffering From Severe Mucosal Lichen Planus.	Unknown status	NCT01538732	Phase 2	alitretinoin
23	A Proof of Concept Study to Evaluate the Efficacy, Safety and Tolerability of Secukinumab 300 mg Over 32 Weeks in Adult Patients With Biopsy-proven Forms of Lichen Planus Not Adequately Controlled With Topical Therapies - PRELUDE	Completed	NCT04300296	Phase 2	Cutaneous lichen planus secukinumab 300 mg Q4W;Cutaneous lichen planus placebo;Mucosal lichen planus placebo;Lichen planopilaris placebo;Mucosal lichen planus secukinumab 300 mg Q4W;Lichen planopilaris secukinumab 300 mg Q4W
24	Treatment of Oral Lichen Planus Lesions	Completed	NCT00746772	Phase 2	Purslane 235mg/day in one dosage;Placebo : one dosage
25	Cedar Honey in Treatment of Oral Lichen Planus: a Randomized Clinical Trial	Completed	NCT01974414	Phase 1, Phase 2	orally administered cedar honey
26	Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other	Completed	NCT00484250	Phase 2	metronidazole,doxycycline
27	Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus- A Double-blinded Randomized Clinical Trial in Sri Lanka	Completed	NCT02744378	Phase 2	Tacrolimus 0.1%;Clobetasol 0.05%
28	Efficacy of Oral Lycopene in the Management of Oral Lichen Planus	Completed	NCT00656214	Phase 2	Lycopene;Placebo
29	The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus and Improvement of Quality of Life: A Randomized, Double Blind, Controlled Study	Completed	NCT02106468	Phase 2	Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
30	A Randomized, Placebo-Controlled, Double-Blind Trial of a Two Week Course of Curcuminoids in Oral Lichen Planus	Completed	NCT00525421	Phase 2	Curcuminoids;Placebo
31	Effect of the Probiotic Bifidobacterium Animalis Subsp. Lactis HN019 on Clinical, Histopathological and Immunophenotypic Features of Oral Lichen Planus	Completed	NCT03386643	Phase 2	Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
32	Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on the Duration and Symptoms of Lesions That Caused by Symptomatic Oral Lichen Planus	Completed	NCT02453503	Phase 2	Licorice;Triamcinolone Acetonide
33	A Randomized, Double-blind, Placebo-controlled, Parallel Group Clinical Study to Assess the Safety and Efficacy of Three Doses of Clobetasol Propionate When Administered Intra-orally Twice Daily in Patients With Oral Lichen Planus (OLP) Using Rivelin®-CLO Patches	Completed	NCT03592342	Phase 2	Clobetasol Propionate
34	A 6-week Randomized, Double-blind, Vehicle-controlled Pilot Study With a 6-week Open Label Extension to Assess the Efficacy and Safety of Pimecrolimus 1% Cream in the Treatment of Oral Lichen Planus	Completed	NCT00297037	Phase 2	Pimecrolimus 1% cream
35	Dexamethasone 0.01% Solution for the Treatment of Oral Lichen Planus	Completed	NCT00111072	Phase 2	dexamethasone 0.01% solution
36	Hydroxychloroquine Versus Clobetasol 0.05% Rinse for the Treatment of Oral Lichen Planus	Completed	NCT00102557	Phase 2	Hydroxychloroquine
37	Evaluation of the Effectiveness of Photodynamic Therapy in the Treatment of Lesions of the Lichen Planus Type in the Oral Mucosa and Its Diagnostics With the Use of Autofluorescence, in Various Wavelength Ranges, in Combination With the Use of Texture Analysis and Fractal Dimension	Completed	NCT04991012	Phase 2	Triamcinolone (Substance) therapy side
38	A Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus- Split-Mouth Randomised	Completed	NCT04976673	Phase 2	Triamcinolone Acetonide
39	Nonaromatic Naphthalan - Composition Study and Biological Effects on Epithelial Tissues	Completed	NCT02920658	Phase 2	NAVS Naphthalan;0.05% Betamethasone dipropionate
40	Dexamethasone Solution and Dexamethasone in Mucolox™ for the Treatment of Oral Lichen Planus	Completed	NCT02850601	Phase 2	Dexamethasone
41	INCB018424 in the Treatment of Cutaneous Lichen Planus	Completed	NCT03697460	Phase 2	INCB018424
42	KPL-716-C202: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Pilot Study to Investigate the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Diseases Characterized by Chronic Pruritus	Completed	NCT03858634	Phase 2	KPL-716;Placebo
43	Valchlor in the Treatment of Lichen Planopilaris: A Single Arm, Open- Label, Exploratory Study	Completed	NCT03417141	Phase 2	Mechlorethamine 0.016% Top Gel
44	Oral Low-Dose Naltrexone in the Treatment of Lichen Planopilaris and Frontal Fibrosing Alopecia; an Uncontrolled Open-label Prospective Study	Completed	NCT04409041	Phase 2	Low-Dose Naltrexone
45	Dexamethasone Solution and Dexamethasone in Mucolox™ for the Treatment of Oral Inflammatory Ulcerative Diseases	Recruiting	NCT04540133	Phase 2	dexamethasone 0.5mg/5ml solution;dexamethasone 0.5mg/5ml solution in Mucolox™
46	A Randomized, Double-Blind, Vehicle-Controlled Study of the Efficacy and Safety of Ruxolitinib Cream in Participants With Cutaneous Lichen Planus	Recruiting	NCT05593432	Phase 2	Ruxolitinib cream;Vehicle cream
47	The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans	Recruiting	NCT04233749	Phase 2	Tranexamic acid tablets
48	The AP-GELP Study: A Randomized, Placebo-Controlled Clinical Trial on the Effects of Phosphodiesterase 4-Inhibitor Apremilast in Female Genital Erosive Lichen Planus	Recruiting	NCT03656666	Phase 2	Apremilast;Placebo
49	Baricitinib (LY3009104) in the Treatment of Cutaneous Lichen Planus	Recruiting	NCT05188521	Phase 2	Baricitinib (LY3009104)
50	A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus	Terminated	NCT00226174	Phase 2	Curcuminoids

Search NIH Clinical Center for Lichen Planus

Cochrane evidence based reviews: lichen planus

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Genetic Tests for Lichen Planus

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Anatomical Context for Lichen Planus

Organs/tissues related to Lichen Planus:

FMA: Skin, Tongue

MalaCards : Skin, Tongue, Thyroid, T Cells, Liver, Bone Marrow, Salivary Gland

Sources

Publications for Lichen Planus

Articles related to Lichen Planus:

(show top 50) (show all 8671)

#	Title	Authors	PMID	Year
1	T cells reactive with the NC16A domain of BP180 are present in vulval lichen sclerosus and lichen planus. ⁵³ ⁶²	Baldo M...Wojnarowska F	19686329	2010
2	Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus. ⁵³ ⁶²	Ammar M...Louzir H	18331568	2008
3	The expression of TNF-alpha and ICAM-1 in lesions of lichen planus and its implication. ⁵³ ⁶²	Chen X...Yue Q	18231758	2007
4	Cytokine alterations in lichen sclerosus: an immunohistochemical study. ⁵³ ⁶²	Farrell AM...Wojnarowska F	17034521	2006
5	Collagen XVII/BP180: a collagenous transmembrane protein and component of the dermoepidermal anchoring complex. ⁵³ ⁶²	Powell AM...Black MM	16197389	2005
6	Cytotoxic molecule expression and epithelial cell apoptosis in oral and cutaneous lichen planus. ⁵³ ⁶²	Santoro A...Facchetti F	15151217	2004
7	Lichen planus and leukocytoclastic vasculitis induced by interferon alpha-2b in a subject with HCV-related chronic active hepatitis. ⁵³ ⁶²	Pinto JM...Correia TE	12705750	2003
8	Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses: CD1a+, factor XIIIa+, and CD68+ cells in eczematous dermatitis, psoriasis, lichen planus and graft-versus-host disease. ⁵³ ⁶²	Deguchi M...Tagami H	12373334	2002
9	Oral lichen planus: an update. ⁵³ ⁶²	Agarwal R...Saraswat A	12582419	2002
10	Topical retinaldehyde treatment in oral lichen planus and leukoplakia. ⁵³ ⁶²	Boisnic S...Dupuy P	12779246	2002
11	Upregulation of human beta-defensin 2 peptide expression in oral lichen planus, leukoplakia and candidiasis. an immunohistochemical study. ⁵³ ⁶²	Abiko Y...Kaku T	12389997	2002
12	Identification of the AgNORs, PCNA and ck16 proteins in oral lichen planus lesions. ⁵³ ⁶²	da Silva Fonseca LM...do Carmo MA	11834097	2001
13	Presence of lichen planus during a course of interferon alpha-2a therapy for a viral chronic C hepatitis. ⁵³ ⁶²	Guijarro Guijarro B...Hernandez Vallejo G	11694869	2001
14	Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation. ⁵³ ⁶²	Flier J...Tensen CP	11523046	2001
15	Lichen planus exacerbation by interferon-alpha-2A for chronic viral hepatitis C. ⁵³ ⁶²	Al Ghamdi AS...Laajam MA	19864712	2000
16	Lichenoid dermatitis in paraneoplastic pemphigus: a pathogenic trigger of epitope spreading? ⁵³ ⁶²	Bowen GM...Stevens SR	10815859	2000
17	Lichen planus induced by interferon-alpha-2B therapy in a patient with cutaneous malignant melanoma. ⁵³ ⁶²	Herrera Saval A...Camacho Martinez F	10494726	1999
18	Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180. ⁵³ ⁶²	Zillikens D...Giudice GJ	10417629	1999
19	Acquired skin disease of hemidesmosomes. ⁵³ ⁶²	Zillikens D	10379705	1999
20	Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). ⁵³ ⁶²	Tensen CP...Willemze R	10233762	1999
21	BP180/type XVII collagen: its role in acquired and inherited disorders or the dermal-epidermal junction. ⁵³ ⁶²	Zillikens D...Giudice GJ	10335914	1999
22	C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells. ⁵³ ⁶²	Fayyazi A...Zwirner J	10027407	1999
23	MIG is a dominant lymphocyte-attractant chemokine in lichen planus lesions. ⁵³ ⁶²	Spandau U...Gillitzer R	9856808	1998
24	The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus. ⁵³ ⁶²	Shimizu M...Kawashima M	9341973	1997
25	Keratin and involucrin expression in discoid lupus erythematosus and lichen planus. ⁵³ ⁶²	Ichikawa E...Takahashi H	9341972	1997
26	Altered distribution and synthesis of laminin-5 (kalinin) in oral lichen planus, epithelial dysplasias and squamous cell carcinomas. ⁵³ ⁶²	Kainulainen T...Salo T	9115910	1997
27	Lichen planus and chronic hepatitis C: exacerbation of the lichen under interferon-alpha-2a therapy. ⁵³ ⁶²	Areias J...Saraiva AM	8864684	1996
28	Vascular adhesion molecules in oral lichen planus. ⁵³ ⁶²	Regezi JA...McCalmont TH	8784900	1996
29	Destruction of the epithelial anchoring system in lichen planus. ⁵³ ⁶²	Haapalainen T...Salo T	7615961	1995
30	In three types of interface dermatitis, different patterns of expression of intercellular adhesion molecule-1 (ICAM-1) indicate different triggers of disease. ⁵³ ⁶²	Bennion SD...Norris DA	7616001	1995
31	Lichen planus induced by interferon-alpha-2a therapy for chronic active hepatitis C. ⁵³ ⁶²	Barreca T...Rolandi E	7600144	1995
32	Alteration of cytokeratin expression in oral lichen planus. ⁵³ ⁶²	Boisnic S...Szpirglas H	7542150	1995
33	Expression of MxA protein in inflammatory dermatoses. ⁵³ ⁶²	Fah J...Burg G	7822763	1995
34	Analysis of mast cell subpopulations (MCT, MCTC) in cutaneous inflammation using novel enzyme-histochemical staining techniques. ⁵³ ⁶²	Algermissen B...Czarnetzki BM	7538409	1994
35	Immunofluorescent analysis of the basement membrane zone in lichen planus suggests destruction of the lamina lucida in bullous lesions. ⁵³ ⁶²	Smoller BR...Glusac EJ	8040461	1994
36	Increased submucosal factor XIIIa-positive dendrocytes in oral lichen planus. ⁵³ ⁶²	Regezi JA...Nickoloff BJ	7517451	1994
37	Lymphocyte and macrophage subsets in active and inactive lesions of lichen planus. ⁵³ ⁶²	Akasu R...Kahn HJ	8100122	1993
38	Epidermal dendritic cells in psoriasis possess a phenotype associated with antigen presentation: in situ expression of beta 2-integrins. ⁵³ ⁶²	McGregor JM...MacDonald DM	1401271	1992
39	Expression of the CD54 (ICAM-1) and CD11a (LFA-1) adhesion molecules in oral mucosal inflammation. ⁵³ ⁶²	Verdickt GM...Walsh LJ	1348286	1992
40	Elastolysis in lichen ruber planus. ⁵³ ⁶²	Dahlback K...Sakai LY	1681662	1991
41	[Lichen planus: etiopathogenesis]. ⁵³ ⁶²	Andre J...Delavault P	1983174	1990
42	Cytokine modulation of adhesion molecules in the regulation of immunologic cytotoxicity of epidermal targets. ⁵³ ⁶²	Norris DA	2258627	1990
43	Induction and upregulation of adhesion receptors in oral and dermal lichen planus. ⁵³ ⁶²	Konter U...Sterry W	1981078	1990
44	Lichen planus pemphigoides: case report and results of immunofluorescence and immunoelectron microscopic study. ⁵³ ⁶²	Okochi H...Tamaki K	2180994	1990
45	Immunohistochemical studies on fibrillin in amyloidosis, lichen ruber planus and porphyria. ⁵³ ⁶²	Dahlback K...Sakai L	1699374	1990
46	Etretinate suppresses ICAM-1 expression by lesional keratinocytes in healing cutaneous lichen planus. ⁵³ ⁶²	Simon M...Hunyadi J	1979727	1990
47	Rapid resolution of widespread cutaneous lichen planus and generalized pruritus in an elderly patient following treatment with dupilumab. ⁶²	Kazemi S...Hawkes JE	36439781	2022
48	Laryngeal lichen planus mimicking vocal fold dysplasia. ⁶²	Leoncini G...Zanetti L	33965285	2022
49	Will there be a critical review on the malignant transformation of oral lichen planus? ⁶²	Migliari D	36473365	2022
50	Association of autoimmune comorbidities with lichen planus: A United States-based case-control study in the All of Us research program. ⁶²	Fan R...Cohen JM	35931217	2022

Sources

Genes for Lichen Planus

Genes related to Lichen Planus (0 elite genes):

(show all 32)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	COL17A1	Collagen Type XVII Alpha 1 Chain	Protein Coding	23.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16197389 10417629 10335914 (more) 19686329 10379705
2	DST	Dystonin	Protein Coding	22.75	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2180994 8040461
3	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	20.14	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8784900 18231758 12582419 (more) 1979727 7616001 2258627 17034521 1981078 1983174 7517451
4	MX1	MX Dynamin Like GTPase 1	Protein Coding	20.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7822763
5	FLG	Filaggrin	Protein Coding	19.62	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12779246
6	CXCR3	C-X-C Motif Chemokine Receptor 3	Protein Coding	19.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9856808 11523046
7	IVL	Involucrin	Protein Coding	18.65	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9341972
8	ITGAL	Integrin Subunit Alpha L	Protein Coding	18.13	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8784900 1348286 17034521
9	DSG3	Desmoglein 3	Protein Coding	17.73	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10815859
10	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	17.71	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9856808
11	DEFB4A	Defensin Beta 4A	Protein Coding	17.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12389997
12	KRT10	Keratin 10	Protein Coding	17.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12779246
13	GZMB	Granzyme B	Protein Coding	16.92	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18331568 9341973 15151217
14	KRT13	Keratin 13	Protein Coding	16.84	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7542150
15	MIR31	MicroRNA 31	RNA Gene	16.64	DISEASES inferred ¹⁴ ¹⁴ GeneCards inferred via : Publications (show sections)
16	TNF	Tumor Necrosis Factor	Protein Coding	16.2	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	LAMC2	Laminin Subunit Gamma 2	Protein Coding	16.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7615961 9115910
18	KRT16	Keratin 16	Protein Coding	15.87	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11834097
19	IFNG	Interferon Gamma	Protein Coding	15.33	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	KRT1	Keratin 1	Protein Coding	15.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7542150
21	IL6	Interleukin 6	Protein Coding	15.25	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
22	MIR142	MicroRNA 142	RNA Gene	15.24	DISEASES inferred ¹⁴ ¹⁴ GeneCards inferred via : Publications (show sections)
23	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	15.17	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
24	IL17A	Interleukin 17A	Protein Coding	15.04	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
25	IL10	Interleukin 10	Protein Coding	14.87	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
26	IL4	Interleukin 4	Protein Coding	14.86	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
27	TP53	Tumor Protein P53	Protein Coding	14.74	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
28	IL2	Interleukin 2	Protein Coding	14.55	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
29	IL1B	Interleukin 1 Beta	Protein Coding	14.51	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
30	DSG1	Desmoglein 1	Protein Coding	14.49	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
31	CD1A	CD1a Molecule	Protein Coding	14.18	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
32	FOXP3	Forkhead Box P3	Protein Coding	14.07	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)

Sources

Variations for Lichen Planus

Sources

Expression for Lichen Planus

Search GEO for disease gene expression data for Lichen Planus.

Sources

Pathways for Lichen Planus

Pathways related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	Extracellular matrix organization ⁶⁶ Show member pathways Degradation of the extracellular matrix ⁶⁶	12.5	LAMC2 ITGAL ICAM1 DST COL17A1
2	COPI-independent Golgi-to-ER retrograde traffic ⁶⁶ Show member pathways Cell cycle Spindle assembly and chromosome separation ²² Cytoskeleton remodeling Keratin filaments ²² Cytoskeleton remodeling Neurofilaments ²² HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand ⁶⁶	12.33	KRT16 KRT13 KRT1 DST
3	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.71	KRT16 KRT13 KRT10 KRT1 IVL FLG
4	Burn wound healing ⁷⁴	11.56	TNF ICAM1 FLG
5	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.47	TNF IFNG ICAM1
6	miRNAs involvement in the immune response in sepsis ⁷⁴	11.45	TNF ICAM1 GZMB
7	Allograft rejection ⁷⁴	11.43	TNF IFNG GZMB CXCL9
8	Non-genomic actions of 1,25 dihydroxyvitamin D3 ⁷⁴	11.32	DEFB4A IFNG TNF
9	Immune response_Role of integrins in NK cells cytotoxicity ²²	11.22	ITGAL IFNG ICAM1
10	Innate Lymphoid Cells Differentiation ⁶⁵	11.16	TNF IFNG GZMB CXCR3
11	Type II interferon signaling ⁷⁴	11.11	IFNG ICAM1 CXCL9
12	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.05	TNF IFNG GZMB
13	Interactions of natural killer cells in pancreatic cancer ⁷⁴	10.86	TNF IFNG GZMB
14	G-protein signaling_Rap2B regulation pathway ²²	10.83	TNF LAMC2 ITGAL CXCL9 COL17A1
15	LDL Oxidation in Atherogenesis ⁶⁴	10.75	TNF ICAM1

Sources

GO Terms for Lichen Planus

Cellular components related to Lichen Planus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	10.13	COL17A1 CXCL9 DEFB4A ICAM1 IFNG KRT1
2	hemidesmosome	GO:0030056	9.56	DST COL17A1
3	intermediate filament	GO:0005882	9.56	KRT16 KRT13 KRT10 KRT1 DST
4	cornified envelope	GO:0001533	9.4	KRT16 KRT10 KRT1 IVL FLG DSG3

Biological processes related to Lichen Planus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response	GO:0006952	9.91	TNF MX1 DEFB4A CXCL9
2	establishment of skin barrier	GO:0061436	9.85	KRT16 KRT1 FLG
3	hemidesmosome assembly	GO:0031581	9.76	DST COL17A1
4	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	GO:0002291	9.71	ITGAL ICAM1
5	positive regulation of nitrogen compound metabolic process	GO:0051173	9.62	IFNG TNF
6	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.56	IFNG TNF
7	keratinocyte differentiation	GO:0030216	9.56	KRT16 KRT10 IVL FLG
8	positive regulation of vitamin D biosynthetic process	GO:0060557	9.46	TNF IFNG
9	peptide cross-linking	GO:0018149	9.23	KRT10 KRT1 IVL FLG