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MCID: LCH002
MIFTS: 59

Lichen Planus

Categories: Genetic diseases, Immune diseases, Oral diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lichen Planus

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MalaCards integrated aliases for Lichen Planus:

Name: Lichen Planus 12 77 38 56 45 15 17 74
Lichen, Ruber Planus 12
Lichen Ruber Planus 12

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Skin diseases Oral diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:9201
KEGG 38 H01654
ICD9CM 36 697.0
MeSH 45 D008010
NCIt 51 C3189
SNOMED-CT 69 4776004
ICD10 34 L43 L43.9
UMLS 74 C0023646
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Summaries for Lichen Planus

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Disease Ontology : 12 A lichen disease that is located in skin, located in tongue or located in oral mucosa, which presents itself in the form of papules, lesions or rashes.

MalaCards based summary : Lichen Planus, also known as lichen, ruber planus, is related to lichen planus pemphigoides and lichen sclerosus, and has symptoms including pruritus An important gene associated with Lichen Planus is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Allograft rejection and Influenza A. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue or and skin, and related phenotypes are Increased gamma-H2AX phosphorylation and digestive/alimentary

Wikipedia : 77 Lichen planus (LP) is a chronic inflammatory and immune mediated disease that affects the skin, nails,... more...

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Related Diseases for Lichen Planus

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Diseases in the Lichen Planus family:

Lichen Planus, Familial Rare Lichen Planus

Diseases related to Lichen Planus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 386)
# Related Disease Score Top Affiliating Genes
1 lichen planus pemphigoides 34.9 COL17A1 DST
2 lichen sclerosus 31.5 COL17A1 GZMB TP53
3 graft-versus-host disease 31.3 GZMB IFNG TNF
4 gingivitis 31.1 DEFB4A IL4 TNF
5 pemphigus 31.1 COL17A1 DSG3 DST
6 alopecia areata 31.1 GZMB ICAM1 IFNG TNF
7 keratosis 31.0 FLG IVL KRT10
8 paraneoplastic pemphigus 30.9 COL17A1 DSG3 DST
9 periodontitis 30.8 IFNG IL4 TNF
10 conjunctivitis 30.8 ICAM1 IFNG IL4
11 myasthenia gravis 30.8 IFNG IL4 TNF
12 keratoconjunctivitis 30.8 ICAM1 IFNG IL4 TNF
13 erythema multiforme 30.7 CXCR3 GZMB ICAM1 IFNG TNF
14 dermatitis, atopic 30.5 DEFB4A FLG ICAM1 IFNG IL4 TNF
15 autoimmune disease 30.5 COL17A1 IFNG IL4 TNF
16 pemphigoid gestationis 30.5 COL17A1 DST
17 bullous pemphigoid 30.4 COL17A1 DSG3 DST IVL
18 acquired immunodeficiency syndrome 30.4 IFNG TNF TP53
19 keratoacanthoma 30.3 FLG GZMB KRT10 KRT16 TP53
20 cutaneous lupus erythematosus 30.3 CXCR3 GZMB ICAM1 MX1 TNF
21 linear iga disease 30.3 COL17A1 DST
22 vulvar intraepithelial neoplasia 30.3 KRT10 TP53
23 acute graft versus host disease 30.3 GZMB IFNG IL4 TNF
24 multiple sclerosis 30.3 CXCR3 ICAM1 IFNG IL4 MX1 TNF
25 systemic lupus erythematosus 30.3 CXCR3 ICAM1 IFNG IL4 MX1 TNF
26 rheumatoid arthritis 30.2 FLG ICAM1 IFNG IL4 ITGAL TNF
27 discoid lupus erythematosus 30.1 FLG GZMB IVL KRT10 KRT16
28 allergic contact dermatitis 30.0 CXCR3 FLG ICAM1 IFNG IL4 TNF
29 tinea corporis 29.9 DEFB4A KRT16
30 epidermolytic hyperkeratosis 29.9 FLG KRT10 KRT16
31 papilloma 29.9 FLG IL4 IVL KRT10 KRT13 TP53
32 mycosis fungoides 29.9 CXCL9 CXCR3 GZMB ITGAL
33 contact dermatitis 29.5 CXCR3 FLG ICAM1 IFNG IL4 IVL
34 lichen disease 28.8 COL17A1 CXCL9 CXCR3 DST FLG ICAM1
35 actinic lichen planus 12.9
36 lichen planus pigmentosus 12.9
37 oral lichen planus 12.9
38 linear lichen planus 12.9
39 atrophic lichen planus 12.8
40 annular lichen planus 12.8
41 annular atrophic lichen planus 12.8
42 bullous lichen planus 12.6
43 rare lichen planus 12.5
44 lichen planopilaris 12.3
45 lichen planus, familial 12.3
46 graham-little-piccardi-lassueur syndrome 12.1
47 vulvovaginal gingival syndrome 11.8
48 lichen nitidus 11.6
49 nail disorder, nonsyndromic congenital, 1 11.6
50 amyloidosis, primary localized cutaneous, 1 11.3

Graphical network of the top 20 diseases related to Lichen Planus:



Diseases related to Lichen Planus
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Symptoms & Phenotypes for Lichen Planus

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UMLS symptoms related to Lichen Planus:


pruritus

GenomeRNAi Phenotypes related to Lichen Planus according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased gamma-H2AX phosphorylation GR00053-A 9.28 COL17A1 CXCL9 CXCR3 DEFB4A DSG3 IVL

MGI Mouse Phenotypes related to Lichen Planus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 DSG3 ICAM1 IFNG IL4 KRT16 TNF
Sources

Drugs & Therapeutics for Lichen Planus

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Drugs for Lichen Planus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 152)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
2
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 1401-55-4
3
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 124-94-7 31307
4
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 137071-32-0 17753757 6447131
5
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
6
Tacrolimus Approved, Investigational Phase 4,Phase 2,Not Applicable 104987-11-3 445643 439492 6473866
7
Apremilast Approved, Investigational Phase 4,Phase 2 608141-41-9 11561674
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 22916-47-8 4189
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
10
Chitosan Approved Phase 4 9012-76-4 71853
11
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
12
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2 302-25-0
13
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
15
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2 2921-57-5
16 Lycopene Approved, Investigational Phase 4,Phase 2 502-65-8 53477748
17
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
18
Prednisolone hemisuccinate Experimental Phase 4,Phase 2 2920-86-7
19
Lactitol Investigational Phase 4 585-86-4, 585-88-6 493591
20 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
21 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
24 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
27 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
28 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
32 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
33 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Early Phase 1
34 Antiemetics Phase 4,Phase 3,Phase 2,Early Phase 1
35 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
36 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
38 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
39 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Dermatologic Agents Phase 4,Phase 2,Phase 3,Early Phase 1
41 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
42 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Betamethasone Valerate Phase 4,Phase 3,Phase 2,Not Applicable 2152-44-5
44 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Betamethasone benzoate Phase 4,Phase 3,Phase 2,Not Applicable
46 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
47 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2,Not Applicable
48 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2,Not Applicable
49 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
50 Angiogenesis Modulating Agents Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 88)
# Name Status NCT ID Phase Drugs
1 Management of Pain in Oral Lichen Planus Completed NCT03572959 Phase 4 0.1 % topical triamcinolone acetonide
2 Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus Completed NCT02858297 Phase 4 Glucosamine sulfate;triamcinolone acetonide
3 A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus Completed NCT02587117 Phase 4 lycopene;Prednisolone
4 Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus Completed NCT02443311 Phase 4 Pimecrolimus 1% cream;Betamethasone 17-valerate 0.1% cream
5 Pain Outcomes Following Intralesional Corticosteroid Injections Recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
6 Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia Recruiting NCT03422640 Phase 4 Apremilast
7 The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus Unknown status NCT01083420 Phase 3 Minocycline;Dexamethasone
8 Treatment of Female Genital Erosive Lichen Planus(GELP) With Hexaminolevulinate PDT Unknown status NCT01282515 Phase 2, Phase 3 clobetasolpropionate;hexaminolevulinate
9 Evaluation of Green Tea as Antioxidant Agent in Management of Oral Lichen Planus Completed NCT02329600 Phase 3 green tea tablets (Green tea extract 5:1) 200 mg;Triamcinolone Acetonide
10 Efficacy of Elidel Cream on Erosive Oral Lichen Planus Completed NCT00130572 Phase 3 Pimecrolimus
11 Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus Completed NCT02421770 Phase 3
12 Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen Terminated NCT01061853 Phase 3 TOPICAL SIROLIMUS (RAPAMUNE*);TOPICAL BETAMETHASONE 0.05%
13 A Randomized Clinical Trial of the Effect of Pimecrolimus Cream 1% Compared With Topical Corticosteroid in Treatment of Erosive Oral Lichen Planus Unknown status NCT01524744 Phase 2 Pimecrolimus ointment;Adcortyl
14 Pilot Study of Apremilast (CC-10004) in the Treatment of Moderate to Severe Lichen Planus Unknown status NCT01041625 Phase 2 Apremilast (CC-10004)
15 Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin Unknown status NCT01538732 Phase 2 alitretinoin
16 Treatmant of Oral Lichen Planus With Lycopene Completed NCT00656214 Phase 2 Lycopene;Placebo
17 Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus Completed NCT02453503 Phase 2 Licorice;Triamcinolone Acetonide
18 Efficacy of Purslane in Treatment of Oral Lichen Planus Completed NCT00746772 Phase 2 Purslane 235mg/day in one dosage;Placebo : one dosage
19 Pimecrolimus Cream for Oral Lichen Planus Completed NCT00297037 Phase 2 Pimecrolimus 1% cream
20 The Efficacy of Omega-3 in Treatment of Atrophic/Erosive Lichen Planus Completed NCT02106468 Phase 2 Prednisone tablet 5mg;Omega-3 soft capsules 1000 mg
21 A Clinical Study of Curcuminoids in the Treatment of Oral Lichen Planus Completed NCT00525421 Phase 2 Curcuminoids;Placebo
22 Comparison of Tacrolimus 0.1% and Clobetasol 0.05% in the Management of Symptomatic Oral Lichen Planus Completed NCT02744378 Phase 2 Tacrolimus 0.1%;Clobetasol 0.05%
23 Cedar Honey in Oral Lichen Planus Completed NCT01974414 Phase 1, Phase 2 orally administered cedar honey
24 Dexamethasone to Treat Oral Lichen Planus Completed NCT00111072 Phase 2 dexamethasone 0.01% solution
25 Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus Completed NCT00102557 Phase 2 Hydroxychloroquine
26 Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other Completed NCT00484250 Phase 2 metronidazole,doxycycline
27 Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases Completed NCT02920658 Phase 2 NAVS Naphthalan;0.05% Betamethasone dipropionate
28 Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Participants With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS). Completed NCT01835587 Phase 1, Phase 2 CC-486
29 A Study of Lenalidomide in Pediatric Subjects With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT02538965 Phase 2 Lenalidomide
30 Dexamethasone Solution for the Treatment of Oral Lichen Planus Recruiting NCT02850601 Phase 2 Dexamethasone
31 Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus Recruiting NCT03026478 Phase 2 Betamethasone Dipropionate;Clobetasol Propionate
32 Topical INCB018424 Lichen Planus Recruiting NCT03697460 Phase 2 INCB018424
33 Intra-oral Treatment of OLP With Rivelin®-CLO Patches Recruiting NCT03592342 Phase 2 Clobetasol Propionate
34 Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus Active, not recruiting NCT03386643 Phase 2 Bifidobacterium animalis subsp. lactis HN019;Clobetasol propionate 0.05%
35 Valchlor in the Treatment of Lichen Planopilaris Active, not recruiting NCT03417141 Phase 2 Valchlor
36 THE AP-GELP STUDY: A Clinical Trial on the Effects of Apremilast in Female Genital Erosive Lichen Planus Not yet recruiting NCT03656666 Phase 2 Apremilast;Placebo
37 Apremilast - Oral Lichen Planus Trial Not yet recruiting NCT03836885 Phase 2 Apremilast;Placebo
38 Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus Not yet recruiting NCT03293368 Phase 2 Triamcinolone Acetonide
39 Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. Not yet recruiting NCT03509675 Phase 2 Non-Steroidal Anti-inflammatory Topical Rinse;Placebos
40 A Study to Assess the Efficacy, Safety and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases Not yet recruiting NCT03858634 Phase 2 KPL-716;Placebo
41 A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Curcuminoids in Oral Lichen Planus Terminated NCT00226174 Phase 2 Curcuminoids
42 Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream Terminated NCT00321750 Phase 2 1% pimecrolimus cream
43 A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus Terminated NCT00135733 Phase 2 Amevive (Alefacept);Placebo
44 Use of Etanercept in the Treatment of Moderate to Severe Lichen Planus Terminated NCT00285779 Phase 2 Etanercept;Placebo
45 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain Terminated NCT01584947 Phase 2 Bupivacaine;Placebo
46 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
47 Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus Unknown status NCT01375101 Phase 1 placebo;Quercetin
48 The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients Not yet recruiting NCT03877679 Phase 1 Triamcinolone;Turmeric paste
49 Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus Not yet recruiting NCT03793634 Phase 1 topical chamomile
50 Incidence of Esophageal Lichen Planus in Patients With Known Oral Lichen Planus Unknown status NCT02532166 Not Applicable

Search NIH Clinical Center for Lichen Planus

Cochrane evidence based reviews: lichen planus

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Genetic Tests for Lichen Planus

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Anatomical Context for Lichen Planus

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The Foundational Model of Anatomy Ontology organs/tissues related to Lichen Planus:

20
Skin, Tongue Or

MalaCards organs/tissues related to Lichen Planus:

42
Skin, T Cells, Tongue, Thyroid, Myeloid, Testes, Endothelial
Sources

Publications for Lichen Planus

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Articles related to Lichen Planus:

(show top 50) (show all 3397)
# Title Authors Year
1
Case of actinic lichen planus: The second Japanese case. ( 30811059 )
2019
2
Artificial nail wearing: unexpected elicitor of allergic contact dermatitis, oral lichen planus and risky arthroplasty. ( 30793321 )
2019
3
Blaschkolinear Lichen Planus Pigmentosus in the Setting of Chronic Graft-versus-host Disease. ( 30328472 )
2019
4
The reciprocal association between diabetes mellitus and erosive oral lichen planus. ( 30701640 )
2019
5
Aggressive erosive lichen planus associated with hepatitis C responding to sofosbuvir/ledipasvir treatment. ( 30860163 )
2019
6
Subset of cd8+ and foxp3 + t cells in lichen planus associated with chronic hepatitis c infection. ( 30801844 )
2019
7
Potential pathogenic mechanisms involved in the association between lichen planus and hepatitis C virus infection. ( 30679972 )
2019
8
Deregulated phospholipase D2/mammalian target of rapamycin/hypoxia-inducible factor 1 alpha in peripheral T lymphocytes of oral lichen planus correlated with disease severity. ( 30419486 )
2019
9
Koebnerization of Eruptive Keratoacanthoma Into Lesions of Classic Lichen Planus Treated With Oral Acitretin. ( 30789517 )
2019
10
Differential diagnosis of leukoplakia versus lichen planus of the oral mucosa based on digital texture analysis in intraoral photography. ( 30916899 )
2019
11
Oral lichen planus and lichen planopilaris complicated with thymoma. ( 30758883 )
2019
12
Topical calcineurin inhibitors in the treatment of oral lichen planus: a systematic review and meta-analysis. ( 30903622 )
2019
13
Implications on pathogenesis and risk of oral lichen planus neoplastic transformation: an ex-vivo retrospective immunohistochemical study. ( 30907426 )
2019
14
Brimonidine-induced unilateral ocular lichen planus: a case report. ( 30916215 )
2019
15
Circulating exosomes regulate T-cell-mediated inflammatory response in oral lichen planus. ( 30447107 )
2019
16
IL-25 promotes Th2-type reactions and correlates with disease severity in the pathogenesis of oral lichen planus. ( 30472360 )
2019
17
Cutaneous, genital and oral lichen planus: A descriptive study of 274 patients. ( 30573709 )
2019
18
Tumescent Liposuction-Induced Koebnerization of Lichen Planus. ( 30608289 )
2019
19
'Nasal flossing': A case report of nasopharyngeal stenosis due to severe erosive lichen planus and a novel therapeutic intervention. ( 30611058 )
2019
20
Curcumin, a turmeric extract, for oral lichen planus: A systematic review. ( 30614166 )
2019
21
Could colchicine represent a new therapeutic approach for lichen planus pigmentosus? ( 30614614 )
2019
22
Subclinical atherosclerosis and cardiovascular markers in patients with lichen planus: A case-control study. ( 30632483 )
2019
23
Downregulated miR-27b promotes keratinocyte proliferation by targeting PLK2 in oral lichen planus. ( 30638284 )
2019
24
Low dose thalidomide monotherapy for the treatment of recalcitrant erosive lichen planus. ( 30638289 )
2019
25
Evaluation of serum and salivary interferon-γ levels in patients with oral lichen planus: a systematic review and meta-analysis of case-control studies. ( 30642701 )
2019
26
Role of miR-155 in immune regulation and its relevance in oral lichen planus. ( 30651838 )
2019
27
Isolated lichen planus of lip: Diagnosis and treatment monitoring using dermoscopy. ( 30656029 )
2019
28
Modified phenol peels for treatment-refractory hyperpigmentation of lichen planus pigmentosus: A retrospective clinico-dermoscopic analysis. ( 30661300 )
2019
29
miR‑122 and miR‑199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway. ( 30664152 )
2019
30
Masturbation-induced painless hemorrhagic bulla on scarring penile lichen planus. ( 30665993 )
2019
31
Assessment of Interleukin - 18 gene polymorphism and serum levels in Oral Lichen Planus in an Indian population. ( 30672022 )
2019
32
Role of modern imaging techniques for the in vivo diagnosis of lichen planus. ( 30679973 )
2019
33
Letter to the Editor: Nail Lichen Planus: A True Nail Emergency. ( 30682392 )
2019
34
Nail lichen planus. ( 30682393 )
2019
35
Impressive oral lichen planus progression to invasive squamous cell carcinoma in a three months lapse. ( 30704849 )
2019
36
Artemisinin and its derivatives: a potential therapeutic approach for oral lichen planus. ( 30707255 )
2019
37
Lichen planus pigmentosus: a case series with different ethnical, clinical and dermoscopic features. ( 30717570 )
2019
38
The Gingival Oral Lichen Planus: A Periodontal-Oral Medicine Approach. ( 30723556 )
2019
39
Invited Review: Association of nitric oxide with oral lichen planus. ( 30725513 )
2019
40
Serum-based metabolomics characterization of patients with reticular oral lichen planus. ( 30731368 )
2019
41
Role of mammary serine protease inhibitor on the inflammatory response in oral lichen planus. ( 30737971 )
2019
42
Expression of Cluster of Differentiation 1a-Positive Langerhans Cells in Oral Lichen Planus. ( 30745634 )
2019
43
Aberrant IGF1-PI3K/AKT/MTOR signaling pathway regulates the local immunity of oral lichen planus. ( 30773287 )
2019
44
In vivo reflectance confocal microscopy of oral lichen planus. ( 30773623 )
2019
45
Dermoscopic Features of Psoriasis, Lichen Planus, and Pityriasis Rosea in Patients With Skin Type IV and Darker Attending the Regional Dermatology Training Centre in Northern Tanzania. ( 30775148 )
2019
46
Comorbidities in Lichen Planus: A Case-control Study in Indian Patients. ( 30775296 )
2019
47
Lichen planus pigmentosus-inversus with epidermal melanin granules. ( 30784094 )
2019
48
Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT. ( 30791744 )
2019
49
Mannose-Binding Lectin 2 (MBL2) combined genotypes deficiency is associated with susceptibility for Oral Lichen Planus. ( 30794720 )
2019
50
Reticular and erosive oral lichen planus have a distinct metabolomic profile: A preliminary study using gas chromatography-mass spectrometry. ( 30801783 )
2019
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Variations for Lichen Planus

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Expression for Lichen Planus

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Search GEO for disease gene expression data for Lichen Planus.
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Pathways for Lichen Planus

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Pathways related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 38
Show member pathways
 12.69 CXCL9 GZMB ICAM1 IFNG IL4 ITGAL
2
Influenza A 38
Show member pathways
 12.45 ICAM1 IFNG IL4 MX1 TNF TP53
3
Human T-cell leukemia virus 1 infection 38
12.29 ICAM1 ITGAL TNF TP53
4
IL-17 Family Signaling Pathways 66
Show member pathways
 12.27 DEFB4A IFNG IL4 TNF
5
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.27 GZMB ICAM1 IFNG IL4 ITGAL TNF
6
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.2 IFNG IL4 MX1 TNF TP53
7
Selenium Micronutrient Network 1
Show member pathways
 12.19 ICAM1 IFNG IL4 TNF TP53
8
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.16 COL17A1 CXCL9 CXCR3 ICAM1 ITGAL
9
Bacterial infections in CF airways 23
Show member pathways
 12.12 DEFB4A IFNG IL4 TNF
10
Keratinization 67
Show member pathways
 12.09 DSG3 FLG IVL KRT10 KRT13 KRT16
11
Fluid shear stress and atherosclerosis 38
12.03 ICAM1 IFNG TNF TP53
12
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.9 IFNG IL4 ITGAL TNF
13
Interleukin-4 and 13 signaling 67
11.88 ICAM1 IL4 TNF TP53
14
Hematopoietic cell lineage 38
11.82 CD1A IL4 TNF
15
Rheumatoid arthritis 38
11.74 ICAM1 IFNG ITGAL TNF
16
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.7 IFNG IL4 TNF
17
Dendritic Cells Developmental Lineage Pathway 66
11.69 CD1A IFNG TNF
18
Glucocorticoid receptor regulatory network 1
11.65 ICAM1 IFNG IL4 TP53
19
Staphylococcus aureus infection 38
11.63 ICAM1 ITGAL KRT10
20
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.61 ICAM1 IFNG TNF
21
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.59 GZMB IFNG TNF
22
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.52 CXCL9 IFNG IL4 TNF
23
Photodynamic therapy-induced AP-1 survival signaling. 1
11.5 IFNG TNF TP53
24
Interleukin-10 signaling 67
11.48 ICAM1 IL4 TNF
25
Spinal Cord Injury 1
11.43 ICAM1 IFNG IL4 TNF TP53
26
Immune response_Role of integrins in NK cells cytotoxicity 23
11.42 ICAM1 IFNG ITGAL
27
Type II interferon signaling (IFNG) 1
11.32 CXCL9 ICAM1 IFNG
28
African trypanosomiasis 38
11.31 ICAM1 IFNG TNF
29
CXCR3-mediated signaling events 1
11.27 CXCL9 CXCR3 ITGAL
30
Malaria 38
11.25 ICAM1 IFNG ITGAL TNF
31
Development and heterogeneity of the ILC family 1
11.23 IFNG IL4 TNF
32
Cytokines and Inflammatory Response 1
11.15 IFNG IL4 TNF
33
G-protein signaling_Rap2B regulation pathway 23
10.96 COL17A1 CXCL9 IL4 ITGAL TNF
34
Innate Lymphoid Cell Differentiation Pathways 66
10.92 CXCR3 GZMB IFNG IL4 TNF
Sources

GO Terms for Lichen Planus

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Cellular components related to Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 COL17A1 CXCL9 DEFB4A ICAM1 IFNG IL4
2 intermediate filament GO:0005882 9.35 DST FLG KRT10 KRT13 KRT16
3 hemidesmosome GO:0030056 9.16 COL17A1 DST
4 cornified envelope GO:0001533 8.92 DSG3 FLG IVL KRT10

Biological processes related to Lichen Planus according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.89 CXCL9 CXCR3 ITGAL KRT16 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.86 ICAM1 IL4 TNF TP53
3 extracellular matrix organization GO:0030198 9.84 COL17A1 ICAM1 ITGAL TNF
4 defense response GO:0006952 9.76 CXCL9 DEFB4A MX1 TNF
5 regulation of immune response GO:0050776 9.72 CD1A COL17A1 ICAM1 IL4 ITGAL
6 peptide cross-linking GO:0018149 9.69 FLG IVL KRT10
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 ICAM1 IFNG TNF
8 keratinization GO:0031424 9.65 DSG3 IVL KRT10 KRT13 KRT16
9 hemidesmosome assembly GO:0031581 9.55 COL17A1 DST
10 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.52 ICAM1 TNF
11 immune response GO:0006955 9.5 CD1A CXCL9 CXCR3 DEFB4A IFNG IL4
12 keratinocyte differentiation GO:0030216 9.46 FLG IVL KRT10 KRT16
13 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
14 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.4 ICAM1 ITGAL
15 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
16 cornification GO:0070268 9.1 DSG3 FLG IVL KRT10 KRT13 KRT16

Molecular functions related to Lichen Planus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 CD1A COL17A1 CXCL9 DEFB4A DST FLG
2 cytokine activity GO:0005125 9.46 CXCL9 IFNG IL4 TNF
3 structural molecule activity GO:0005198 9.1 DST FLG IVL KRT10 KRT13 KRT16
Sources

Sources for Lichen Planus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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