Aliases & Classifications for Lichen Sclerosus

MalaCards integrated aliases for Lichen Sclerosus:

Name: Lichen Sclerosus 53 55
Lichen Sclerosus Et Atrophicus 53 73
Lichen Sclerosis Et Atrophicus 53
Lichen Sclerosis 53

Classifications:



External Ids:

UMLS 73 C0023652

Summaries for Lichen Sclerosus

NIH Rare Diseases : 53 Lichen sclerosus is a chronic skin disorder that is more common in women, most often affecting the external part of the vagina (vulva) or the area around the anus. In men, it typically affects the tip of the penis. It can occur at any age but is usually seen in women over age 50. Some people have no symptoms, while others may experience itchiness (sometimes severe), discomfort, or blistering. It often lasts for years and can cause permanent scarring. The underlying cause of lichen sclerosus is not fully understood but it is thought to relate to an autoimmune process. Treatment may include topical steroids or other types of topical creams and/or surgery.

MalaCards based summary : Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to lichen planus and discoid lupus erythematosus. An important gene associated with Lichen Sclerosus is ECM1 (Extracellular Matrix Protein 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Zinc and Insulin glulisine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid.

Wikipedia : 76 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Related Diseases for Lichen Sclerosus

Diseases related to Lichen Sclerosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 lichen planus 30.4 GZMB TNF TP53
2 discoid lupus erythematosus 30.2 GZMB HLA-DRB1
3 celiac disease 1 29.6 GZMB HLA-DQB1 TNF
4 helicobacter pylori infection 29.3 HLA-DRB1 TNF TP53
5 autoimmune disease 29.3 HLA-DQB1 HLA-DRB1 TNF
6 connective tissue disease 29.0 ELN HLA-DRB1 TNF
7 arthritis 29.0 HLA-DQB1 HLA-DRB1 TNF
8 graft-versus-host disease 28.9 GZMB HLA-DQB1 HLA-DRB1 TNF
9 diabetes mellitus 28.3 GZMB HLA-DQB1 HLA-DRB1 TNF
10 lichen sclerosus et atrophicus 12.7
11 balanitis xerotica obliterans 12.1
12 squamous cell carcinoma 10.7
13 necrotizing sialometaplasia 10.5 GZMB TP53
14 urethritis 10.4
15 papillon-lefevre syndrome 10.4 GZMB HLA-DRB1
16 limbic encephalitis with lgi1 antibodies 10.4 HLA-DQB1 HLA-DRB1
17 keratoacanthoma 10.4 GZMB TP53
18 metal allergy 10.4 HLA-DQB1 HLA-DRB1
19 focal epithelial hyperplasia 10.4 HLA-DQB1 HLA-DRB1
20 hypersomnia 10.4 HLA-DQB1 HLA-DRB1
21 balanitis 10.4
22 lichen planopilaris 10.4 HLA-DQB1 HLA-DRB1
23 type ii mixed cryoglobulinemia 10.4 HLA-DQB1 HLA-DRB1
24 recurrent respiratory papillomatosis 10.4 HLA-DQB1 HLA-DRB1
25 pityriasis rosea 10.3 HLA-DQB1 HLA-DRB1
26 leukoplakia of penis 10.3
27 whipple disease 10.3 HLA-DQB1 HLA-DRB1
28 acute disseminated encephalomyelitis 10.3 HLA-DQB1 HLA-DRB1
29 pediatric multiple sclerosis 10.3 HLA-DQB1 HLA-DRB1
30 osteonecrosis of the jaw 10.3 HLA-DQB1 HLA-DRB1
31 thyroid lymphoma 10.3 TNF TP53
32 urethral stricture 10.3
33 phimosis 10.3
34 idiopathic bronchiectasis 10.3 HLA-DQB1 HLA-DRB1
35 soft tissue sarcoma 10.3 TNF TP53
36 peanut allergy 10.3 HLA-DQB1 HLA-DRB1
37 vulvar intraepithelial neoplasia 10.3
38 chronic salpingitis 10.2 TNF TP53
39 idiopathic achalasia 10.2 HLA-DQB1 TNF
40 lichen disease 10.2 TNF TP53
41 cheilitis 10.2 TNF TP53
42 erythema multiforme 10.2 GZMB TNF
43 cytomegalovirus retinitis 10.2 HLA-DQB1 TNF
44 sialadenitis 10.2 HLA-DQB1 TNF
45 microscopic polyangiitis 10.2 HLA-DRB1 TNF
46 anca-associated vasculitis 10.2 HLA-DRB1 TNF
47 melanoma 10.2
48 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
49 erysipelas 10.1 ELN TNF
50 rasmussen encephalitis 10.1 GZMB TNF

Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to Lichen Sclerosus

Symptoms & Phenotypes for Lichen Sclerosus

Drugs & Therapeutics for Lichen Sclerosus

Drugs for Lichen Sclerosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4 7440-66-6 23994
2
Insulin glulisine Approved Phase 4 207748-29-6
3 insulin Phase 4
4 Hypoglycemic Agents Phase 4
5 Insulin, Globin Zinc Phase 4
6
Clobetasol Approved, Investigational Phase 3,Phase 2,Not Applicable 25122-46-7, 25122-41-2 32798 5311051
7 glucocorticoids Phase 3,Phase 2,Not Applicable
8 Hormone Antagonists Phase 3,Phase 2,Not Applicable
9 Hormones Phase 3,Phase 2,Not Applicable
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
11 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
12
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
13
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
14
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
15
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
16
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
17 Analgesics Phase 2
18 Cortisol succinate Phase 2
19 Analgesics, Non-Narcotic Phase 2
20 Dermatologic Agents Phase 2,Not Applicable
21 Hydrocortisone 17-butyrate 21-propionate Phase 2
22 Hydrocortisone acetate Phase 2
23 Hydrocortisone-17-butyrate Phase 2
24 Peripheral Nervous System Agents Phase 2
25 Immunosuppressive Agents Phase 2,Not Applicable
26 Antipruritics Phase 2
27 Anti-Inflammatory Agents, Non-Steroidal Phase 2
28 Antirheumatic Agents Phase 2
29 Calcineurin Inhibitors Phase 2
30 Progestins Phase 2
31
Methylene blue Approved, Investigational Phase 1,Not Applicable 61-73-4
32
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
33
Ropivacaine Approved Phase 1 84057-95-4 71273 175805
34 Dexamethasone acetate Phase 1 1177-87-3
35 BB 1101 Phase 1
36
Cortisone acetate Approved, Investigational Not Applicable 1950-04-4, 50-04-4 5745
37
Petrolatum Approved, Investigational Not Applicable 8009-03-8
38
Menthol Approved Not Applicable 2216-51-5 16666
39
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
40
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
41
Cortisone Not Applicable 53-06-5 222786
42 Emollients Not Applicable
43 triamcinolone acetonide Not Applicable
44 Retinol palmitate Not Applicable
45 Triamcinolone diacetate Not Applicable
46 Triamcinolone hexacetonide Not Applicable
47 Estrogens Not Applicable
48 Acidophilus Nutraceutical Not Applicable
49 retinol Nutraceutical Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
2 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3 Clobetasol Propionate 0.05% ointment
3 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2 Tacrolimus cream;Clobetasol cream
4 Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus Completed NCT00393263 Phase 2 pimecrolimus and clobetasol;clobetasol 0.05% cream
5 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
6 Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus Terminated NCT01126255 Phase 2 Clobetasol propionate 0.05%;Progesterone 8%
7 Methylene Blue Injection for Nonneoplastic Epithelial Disorders of Vulva Active, not recruiting NCT03200808 Phase 1 mixed methylene blue compound injection
8 Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus Completed NCT02794363 Not Applicable
9 Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser Completed NCT02416531 Not Applicable Clobetasol propionate
10 Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus Completed NCT01400022 Not Applicable
11 Biomarkers of Lichen Sclerosus Recruiting NCT03561428
12 Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Recruiting NCT03063684 Not Applicable
13 Lichen Sclerosus - the Influence on Quality of Life Recruiting NCT03419377 Not Applicable
14 Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen) Recruiting NCT02761122 Not Applicable
15 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145
16 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995 Not Applicable
17 Vulvar Scarring Grading Scale for Lichen Sclerosus Active, not recruiting NCT02880904
18 Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Active, not recruiting NCT03045172 Not Applicable Saline
19 Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus Active, not recruiting NCT03525522 Not Applicable Topical corticosteroid Diprosone
20 Vulvar Mucosal Specialty Clinic Chart Review Active, not recruiting NCT02881229
21 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Lichen Sclerosus

Genetic Tests for Lichen Sclerosus

Anatomical Context for Lichen Sclerosus

MalaCards organs/tissues related to Lichen Sclerosus:

41
Skin, T Cells, Thyroid, Endothelial, Tongue, Bone Marrow, Bone

Publications for Lichen Sclerosus

Articles related to Lichen Sclerosus:

(show top 50) (show all 717)
# Title Authors Year
1
Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination. ( 29025691 )
2018
2
Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report. ( 29785390 )
2018
3
Association of Retinoic Acid Receptor I^ Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma. ( 29898214 )
2018
4
Blue diode laser: a new strategy for the management of lichen sclerosus et atrophicus. ( 29564880 )
2018
5
Lichen sclerosus in pregnancy: A review of 33 cases. ( 29920642 )
2018
6
Lichen sclerosus on the face. ( 29399776 )
2018
7
Genital Lichen Sclerosus Et Atrophicus: A Benign Skin Disorder With Malignant Aftermath. ( 29729359 )
2018
8
A case of radiation-induced bullous morphea/lichen sclerosus overlap in a breast cancer patient. ( 29872368 )
2018
9
Gender differences in genital lichen sclerosus. ( 29368855 )
2018
10
Vitiligoid variant of lichen sclerosus in young girls with darker skin types. ( 29314207 )
2018
11
Oral lichen sclerosus: a systematic review of reported cases and two new cases. ( 29313955 )
2018
12
Eosinophilic fasciitis and lichen sclerosus in a patient treated with nivolumab. ( 29797309 )
2018
13
Association between Helicobacter pylori infection and vulvar lichen sclerosus: a clinical comparative study. ( 29336317 )
2018
14
Lichen sclerosus of the oral mucosa: clinical and histopathological findings. Review of the literature and a case report. ( 29658796 )
2018
15
Concomitant morphea and lichen sclerosus et atrophicus in the same plaque at the site of intramuscular drug injection: an interesting case presentation. ( 29945269 )
2018
16
Routine histopathological examination of the foreskin after circumcision for clinically suspected Lichen sclerosus in children: Is it a waste of resources? ( 29405913 )
2018
17
British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. ( 29313888 )
2018
18
Lichen Sclerosus Accompanied by Urethral Squamous Cell Carcinoma: A Retrospective Study From a Urethral Referral Center. ( 29926751 )
2018
19
Lichen sclerosus associated with Nd:YAG laser therapy. ( 29856231 )
2018
20
Linear orofacial lichen sclerosus. ( 29405132 )
2018
21
Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. ( 29505429 )
2018
22
Updates in lichen sclerosis: British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. ( 29668094 )
2018
23
Urethral lichen sclerosus under the microscope: a survey of academic pathologists. ( 29900821 )
2018
24
Incidence of vulval squamous cell carcinoma in women with vulval lichen sclerosus in an Australian tertiary referral centre. ( 29932211 )
2018
25
Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review. ( 29271859 )
2018
26
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
27
Bullous lichen sclerosus: isolated vulvar involvement. ( 29630161 )
2018
28
Squamous Cell Carcinoma of the Bulbar Urethra Accompanied by Lichen Sclerosus: A Case Report. ( 29182032 )
2018
29
Extragenital Lichen Sclerosus Induced by Radiotherapy. ( 29566881 )
2018
30
Prospective evaluation of frequency of genital lichen sclerosus in 79 patients with systemic sclerosis. ( 29928761 )
2018
31
Oral lichen sclerosus: an overview and report of three cases. ( 29705404 )
2018
32
Penile Lichen Sclerosus Treated with 1927a88nm Thulium Fiber Laser and Photodynamic Therapy: A New Possible Therapeutic Approach. ( 29298401 )
2018
33
Balanopreputial Adhesion and Paraphimosis due to Lichen Sclerosus. ( 29853765 )
2018
34
Lichen Sclerosus of the Upper Lip: Report of a Case, Utilizing Shikata's Modified Orcein Stain, and Review of the Literature. ( 29707184 )
2018
35
Asymptomatic hyperkeratotic plaque on the vulva of a patient with lichen sclerosus. ( 29424084 )
2018
36
5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: series of ten cases. ( 29258952 )
2017
37
Vulvar lichen sclerosus in women is associated with lower urinary tract symptoms. ( 28593367 )
2017
38
Intradermal injection of autologous platelet-rich plasma for the treatment of vulvar lichen sclerosus. ( 27986140 )
2017
39
Intraepidermal nerve fiber density in vulvar lichen sclerosus and normal vulvar tissues. ( 28820401 )
2017
40
Neurofibromatosis type 1 and lichen sclerosus: an uncommon association. ( 27978612 )
2017
41
The diagnosis and management of male genital lichen sclerosus: a retrospective review of 301 patients. ( 28750140 )
2017
42
Oral lichen sclerosus-a review of clinical presentation, treatment, and clinical outcomes. ( 28867463 )
2017
43
Combined therapy in vulvar lichen sclerosus: does topical tretinoin improve the efficacy of mometasone furoate? ( 28024127 )
2017
44
Genital lichen sclerosus in childhood and adolescence-a retrospective case series of 15 patients: early diagnosis is crucial to avoid long-term sequelae. ( 28856426 )
2017
45
A Transgender Woman With Anogenital Lichen Sclerosus. ( 28877300 )
2017
46
Extramammary Paget's Disease Associated With Genital Wart and Lichen Sclerosus. ( 29202553 )
2017
47
Vestibulovaginal Sclerosis Versus Lichen Sclerosus. ( 29194107 )
2017
48
Dyspareunia in vulvar lichen sclerosus: an overview of a distressing symptom. ( 29249126 )
2017
49
Lichen sclerosus et atrophicus: atypical case simulating lichen planus. ( 28633743 )
2017
50
Genital lichen sclerosus developing around 'ectopic' urethral orifices supports the role of occlusion and urine in its pathogenesis. ( 28081682 )
2017

Variations for Lichen Sclerosus

Expression for Lichen Sclerosus

Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for Lichen Sclerosus

Pathways related to Lichen Sclerosus according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 CD44 HLA-DQB1 HLA-DRB1 TNF TP53
2
Show member pathways
12.54 GZMB HLA-DQB1 HLA-DRB1 TNF
3
Show member pathways
12.39 HLA-DQB1 HLA-DRB1 TNF TP53
4 12.27 CD44 GZMB TNF
5
Show member pathways
12.23 CD44 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.13 HLA-DQB1 HLA-DRB1 TNF
7 11.99 CD44 TNF TP53
8 11.96 HLA-DQB1 HLA-DRB1 TNF TP53
9
Show member pathways
11.93 HLA-DQB1 HLA-DRB1 TNF
10 11.89 HLA-DQB1 HLA-DRB1 TNF
11 11.76 CD44 HLA-DQB1 HLA-DRB1 TP53
12 11.5 HLA-DQB1 HLA-DRB1 TNF
13 11.4 CD44 GZMB TNF
14 11.34 HLA-DQB1 HLA-DRB1
15 11.28 CD44 TP53
16 11.27 TNF TP53
17 11.19 TNF TP53
18 11 HLA-DRB1 TNF
19 10.91 CD44 HLA-DQB1 HLA-DRB1 TNF
20 10.72 CD44 ECM1 ELN

GO Terms for Lichen Sclerosus

Cellular components related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
2 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
4 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.54 CD44 ELN TNF
2 antigen processing and presentation GO:0019882 9.46 HLA-DQB1 HLA-DRB1
3 protein tetramerization GO:0051262 9.43 HLA-DRB1 TP53
4 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.4 GZMB TP53
5 interferon-gamma-mediated signaling pathway GO:0060333 9.33 CD44 HLA-DQB1 HLA-DRB1
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.32 HLA-DQB1 HLA-DRB1
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.26 CD44 TNF
8 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
9 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
3 protease binding GO:0002020 8.8 ECM1 TNF TP53

Sources for Lichen Sclerosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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