MCID: LCH009
MIFTS: 44

Lichen Sclerosus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lichen Sclerosus

MalaCards integrated aliases for Lichen Sclerosus:

Name: Lichen Sclerosus 53 55
Lichen Sclerosus Et Atrophicus 53 73
Lichen Sclerosis Et Atrophicus 53
Lichen Sclerosis 53

Classifications:



External Ids:

UMLS 73 C0023652

Summaries for Lichen Sclerosus

NIH Rare Diseases : 53 Lichen sclerosus is a chronic skin disorder that is more common in women, most often affecting the external part of the vagina (vulva) or the area around the anus. In men, it typically affects the tip of the penis. It can occur at any age but is usually seen in women over age 50. Some people have no symptoms, while others may experience itchiness (sometimes severe), discomfort, or blistering. It often lasts for years and can cause permanent scarring. The underlying cause of lichen sclerosus is not fully understood but it is thought to relate to an autoimmune process. Treatment may include topical steroids or other types of topical creams and/or surgery.

MalaCards based summary : Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to lichen planus and graft-versus-host disease. An important gene associated with Lichen Sclerosus is ECM1 (Extracellular Matrix Protein 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Interferon gamma signaling. The drugs Insulin glulisine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid.

Wikipedia : 76 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Related Diseases for Lichen Sclerosus

Diseases related to Lichen Sclerosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 lichen planus 30.9 COL17A1 GZMB TP53
2 graft-versus-host disease 30.3 GZMB HLA-DQB1 HLA-DRB1
3 discoid lupus erythematosus 30.2 GZMB HLA-DRB1
4 autoimmune disease 30.1 COL17A1 HLA-DQB1 HLA-DRB1
5 bullous pemphigoid 30.1 COL17A1 HLA-DQB1 HLA-DRB1
6 lichen sclerosus et atrophicus 12.9
7 balanitis xerotica obliterans 12.2
8 squamous cell carcinoma 10.8
9 localized scleroderma 10.7
10 balanitis 10.5
11 phimosis 10.5
12 leukoplakia of penis 10.5
13 urethral stricture 10.4
14 vulvar intraepithelial neoplasia 10.4
15 melanoma 10.4
16 penile cancer, adult 10.3
17 hepatitis 10.3
18 lupus erythematosus 10.3
19 fasciitis 10.3
20 biliary cirrhosis, primary, 1 10.2
21 breast cancer 10.2
22 granuloma annulare 10.2
23 primary biliary cirrhosis 10.2
24 primary biliary cholangitis 10.2
25 scleroderma, familial progressive 10.2
26 eosinophilic fasciitis 10.2
27 mycosis fungoides 10.2
28 hepatitis c 10.2
29 vulvar melanoma 10.2
30 thyroiditis 10.2
31 psoriasis 10.2
32 chronic graft versus host disease 10.2
33 leukoplakia 10.2
34 limbic encephalitis with lgi1 antibodies 10.1 HLA-DQB1 HLA-DRB1
35 narcolepsy 2 10.1 HLA-DQB1 HLA-DRB1
36 autoimmune polyglandular syndrome type 3 10.1 HLA-DQB1 HLA-DRB1
37 necrotizing sialometaplasia 10.1 GZMB TP53
38 hypersomnia 10.1 HLA-DQB1 HLA-DRB1
39 metal allergy 10.1 HLA-DQB1 HLA-DRB1
40 type ii mixed cryoglobulinemia 10.1 HLA-DQB1 HLA-DRB1
41 beryllium disease 10.1 HLA-DQB1 HLA-DRB1
42 recurrent respiratory papillomatosis 10.1 HLA-DQB1 HLA-DRB1
43 systemic lupus erythematosus 10.1
44 celiac disease 1 10.1
45 langerhans cell histiocytosis 10.1
46 vitiligo-associated multiple autoimmune disease susceptibility 1 10.1
47 hepatitis c virus 10.1
48 alopecia 10.1
49 dermatomyositis 10.1
50 hypospadias 10.1

Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to Lichen Sclerosus

Symptoms & Phenotypes for Lichen Sclerosus

Drugs & Therapeutics for Lichen Sclerosus

Drugs for Lichen Sclerosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Zinc Approved, Investigational Phase 4 7440-66-6
3 Hypoglycemic Agents Phase 4
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4
6
Clobetasol Approved, Experimental, Investigational Phase 3,Phase 2,Not Applicable 25122-46-7, 25122-41-2 5311051 32798
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
8 Hormones Phase 3,Phase 2,Not Applicable
9 Hormone Antagonists Phase 3,Phase 2,Not Applicable
10 glucocorticoids Phase 3,Phase 2,Not Applicable
11 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
12
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
13
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
14
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
15
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
16
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
17 Calcineurin Inhibitors Phase 2
18 Immunologic Factors Phase 2,Not Applicable
19 Immunosuppressive Agents Phase 2,Not Applicable
20 Antirheumatic Agents Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 2
22 Analgesics Phase 2
23 Peripheral Nervous System Agents Phase 2
24 Analgesics, Non-Narcotic Phase 2
25 Dermatologic Agents Phase 2,Not Applicable
26 Hydrocortisone 17-butyrate 21-propionate Phase 2
27 Hydrocortisone-17-butyrate Phase 2
28 Antipruritics Phase 2
29 Cortisol succinate Phase 2
30 Progestins Phase 2
31
Methylene blue Approved, Investigational Phase 1,Not Applicable 61-73-4
32
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
33
Ropivacaine Approved Phase 1 84057-95-4 175805 71273
34
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
35 BB 1101 Phase 1
36
Cortisone acetate Approved, Investigational Not Applicable 1950-04-4, 50-04-4 5745
37
Petrolatum Approved, Investigational Not Applicable 8009-03-8
38
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
39
Betamethasone Approved, Vet_approved Not Applicable 378-44-9 9782
40
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
41
Cortisone Experimental Not Applicable 53-06-5 222786
42 Emollients Not Applicable
43 Triamcinolone diacetate Not Applicable
44 Retinol palmitate Not Applicable
45 triamcinolone acetonide Not Applicable
46 retinol Not Applicable
47 Triamcinolone hexacetonide Not Applicable
48 Acidophilus Not Applicable
49 Estrogens Not Applicable
50 Anti-Asthmatic Agents Not Applicable

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
2 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3 Clobetasol Propionate 0.05% ointment
3 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2 Tacrolimus cream;Clobetasol cream
4 Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus Completed NCT00393263 Phase 2 pimecrolimus and clobetasol;clobetasol 0.05% cream
5 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
6 Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus Terminated NCT01126255 Phase 2 Clobetasol propionate 0.05%;Progesterone 8%
7 Methylene Blue Injection for Nonneoplastic Epithelial Disorders of Vulva Active, not recruiting NCT03200808 Phase 1 mixed methylene blue compound injection
8 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Unknown status NCT02732145
9 Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Completed NCT03045172 Not Applicable Placebo
10 The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients Completed NCT03686800 Not Applicable
11 Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus Completed NCT02794363 Not Applicable
12 Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser Completed NCT02416531 Not Applicable Clobetasol propionate
13 Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus Completed NCT01400022 Not Applicable
14 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable
15 MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus Recruiting NCT03665584 Not Applicable
16 Biomarkers of Lichen Sclerosus Recruiting NCT03561428
17 Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Recruiting NCT03063684 Not Applicable
18 Lichen Sclerosus - the Influence on Quality of Life Recruiting NCT03419377 Not Applicable
19 Laser Therapy for Treatment of Urogenital Symptoms in Women Recruiting NCT03681678
20 Vulvar Scarring Grading Scale for Lichen Sclerosus Active, not recruiting NCT02880904
21 Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus Active, not recruiting NCT03525522 Not Applicable Topical corticosteroid Diprosone
22 Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen) Active, not recruiting NCT02761122 Not Applicable
23 Vulvar Mucosal Specialty Clinic Chart Review Active, not recruiting NCT02881229
24 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Lichen Sclerosus

Genetic Tests for Lichen Sclerosus

Anatomical Context for Lichen Sclerosus

MalaCards organs/tissues related to Lichen Sclerosus:

41
Skin, T Cells, Thyroid, Tongue, Colon, Spinal Cord, Myeloid

Publications for Lichen Sclerosus

Articles related to Lichen Sclerosus:

(show top 50) (show all 1111)
# Title Authors Year
1
Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination. ( 29025691 )
2018
2
Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report. ( 29785390 )
2018
3
Association of Retinoic Acid Receptor I^ Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma. ( 29898214 )
2018
4
Blue diode laser: a new strategy for the management of lichen sclerosus et atrophicus. ( 29564880 )
2018
5
Lichen sclerosus in pregnancy: A review of 33 cases. ( 29920642 )
2018
6
Lichen sclerosus on the face. ( 29399776 )
2018
7
Genital Lichen Sclerosus Et Atrophicus: A Benign Skin Disorder With Malignant Aftermath. ( 29729359 )
2018
8
A case of radiation-induced bullous morphea/lichen sclerosus overlap in a breast cancer patient. ( 29872368 )
2018
9
Gender differences in genital lichen sclerosus. ( 29368855 )
2018
10
Vitiligoid variant of lichen sclerosus in young girls with darker skin types. ( 29314207 )
2018
11
Oral lichen sclerosus: a systematic review of reported cases and two new cases. ( 29313955 )
2018
12
Eosinophilic fasciitis and lichen sclerosus in a patient treated with nivolumab. ( 29797309 )
2018
13
Association between Helicobacter pylori infection and vulvar lichen sclerosus: a clinical comparative study. ( 29336317 )
2018
14
Lichen sclerosus of the oral mucosa: clinical and histopathological findings. Review of the literature and a case report. ( 29658796 )
2018
15
Concomitant morphea and lichen sclerosus et atrophicus in the same plaque at the site of intramuscular drug injection: an interesting case presentation. ( 29945269 )
2018
16
Routine histopathological examination of the foreskin after circumcision for clinically suspected Lichen sclerosus in children: Is it a waste of resources? ( 29405913 )
2018
17
British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. ( 29313888 )
2018
18
Lichen Sclerosus Accompanied by Urethral Squamous Cell Carcinoma: A Retrospective Study From a Urethral Referral Center. ( 29926751 )
2018
19
Lichen sclerosus associated with Nd:YAG laser therapy. ( 29856231 )
2018
20
Linear orofacial lichen sclerosus. ( 29405132 )
2018
21
Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. ( 29505429 )
2018
22
Updates in lichen sclerosis: British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. ( 29668094 )
2018
23
Urethral lichen sclerosus under the microscope: a survey of academic pathologists. ( 29900821 )
2018
24
Incidence of vulval squamous cell carcinoma in women with vulval lichen sclerosus in an Australian tertiary referral centre. ( 29932211 )
2018
25
Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review. ( 29271859 )
2018
26
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
27
Bullous lichen sclerosus: isolated vulvar involvement. ( 29630161 )
2018
28
Squamous Cell Carcinoma of the Bulbar Urethra Accompanied by Lichen Sclerosus: A Case Report. ( 29182032 )
2018
29
Extragenital Lichen Sclerosus Induced by Radiotherapy. ( 29566881 )
2018
30
Prospective evaluation of frequency of genital lichen sclerosus in 79 patients with systemic sclerosis. ( 29928761 )
2018
31
Oral lichen sclerosus: an overview and report of three cases. ( 29705404 )
2018
32
Penile Lichen Sclerosus Treated with 1927a88nm Thulium Fiber Laser and Photodynamic Therapy: A New Possible Therapeutic Approach. ( 29298401 )
2018
33
Balanopreputial Adhesion and Paraphimosis due to Lichen Sclerosus. ( 29853765 )
2018
34
Lichen Sclerosus of the Upper Lip: Report of a Case, Utilizing Shikata's Modified Orcein Stain, and Review of the Literature. ( 29707184 )
2018
35
A case of Bullous Pemphigoid Associated with Lichen Sclerosus et Atrophicus. ( 30210168 )
2018
36
Staged Urethroplasty for Penile Urethral Strictures From Lichen Sclerosus and Failed Hypospadias Repair. ( 29107132 )
2018
37
Vulval lichen planus-lichen sclerosus overlap. ( 29490571 )
2018
38
Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years' duration: A case report. ( 30214805 )
2018
39
Cushing Syndrome Induced by Topical Corticosteroids for the Treatment of Lichen Sclerosus. ( 30244192 )
2018
40
Mucinous Metaplasia of the Vulva in Zoon Vulvitis and Lichen Sclerosus et Atrophicus. Description of 3 Additional Cases of a Rarely Reported Histopathologic Finding. ( 30252696 )
2018
41
Fact or Fiction? Adipose-Derived Stem Cells and Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus. ( 30252710 )
2018
42
Underestimation of genital lichen sclerosus incidence in boys with phimosis: results from a systematic review. ( 30264374 )
2018
43
Can lichen sclerosus be diagnosed by preputial appearance or symptoms? ( 30271758 )
2018
44
Scleredema of Buschke associated with lichen sclerosus: Three cases. ( 30289118 )
2018
45
Extragenital lichen sclerosus et atrophicus within a skin graft scar. ( 30320200 )
2018
46
Extragenital lichen sclerosus successfully treated with narrowband-UVB phototherapy. ( 30325310 )
2018
47
Combining topical tretinoin with mometasone furoate in the treatment of vulvar lichen sclerosus: Results of dermoscopic assessment. ( 30334327 )
2018
48
Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus. ( 30379908 )
2018
49
Male and female genital lichen sclerosus. Clinical and functional classification criteria. ( 30429700 )
2018
50
Nivolumab PD-1 inhibitor immunotherapy associated with vulvar, perineal and perianal lichen sclerosus. ( 30430637 )
2018

Variations for Lichen Sclerosus

Expression for Lichen Sclerosus

Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for Lichen Sclerosus

GO Terms for Lichen Sclerosus

Cellular components related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.5 COL17A1 ECM1 ELN
2 endocytic vesicle membrane GO:0030666 9.43 HLA-DQB1 HLA-DRB1
3 collagen-containing extracellular matrix GO:0062023 9.43 COL17A1 ECM1 ELN
4 ER to Golgi transport vesicle membrane GO:0012507 9.4 HLA-DQB1 HLA-DRB1
5 transport vesicle membrane GO:0030658 9.37 HLA-DQB1 HLA-DRB1
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
8 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.54 CD44 COL17A1 ELN
2 antigen processing and presentation GO:0019882 9.43 HLA-DQB1 HLA-DRB1
3 protein tetramerization GO:0051262 9.4 HLA-DRB1 TP53
4 interferon-gamma-mediated signaling pathway GO:0060333 9.33 CD44 HLA-DQB1 HLA-DRB1
5 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.32 GZMB TP53
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
8 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQB1 HLA-DRB1
2 extracellular matrix structural constituent GO:0005201 9.13 COL17A1 ECM1 ELN
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Lichen Sclerosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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