MCID: LCH009
MIFTS: 44

Lichen Sclerosus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lichen Sclerosus

MalaCards integrated aliases for Lichen Sclerosus:

Name: Lichen Sclerosus 54 56
Lichen Sclerosus Et Atrophicus 54 74
Lichen Sclerosis Et Atrophicus 54
Lichen Sclerosis 54

Classifications:



External Ids:

UMLS 74 C0023652

Summaries for Lichen Sclerosus

NIH Rare Diseases : 54 Lichen sclerosus is a chronic skin disorder that is more common in women, most often affecting the external part of the vagina (vulva) or the area around the anus. In men, it typically affects the tip of the penis. It can occur at any age but is usually seen in women over age 50. Some people have no symptoms, while others may experience itchiness (sometimes severe), discomfort, or blistering. It often lasts for years and can cause permanent scarring. The underlying cause of lichen sclerosus is not fully understood but it is thought to relate to an autoimmune process. Treatment may include topical steroids or other types of topical creams and/or surgery.

MalaCards based summary : Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to lichen planus and discoid lupus erythematosus. An important gene associated with Lichen Sclerosus is ECM1 (Extracellular Matrix Protein 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Interferon gamma signaling. The drugs Insulin glulisine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid.

Wikipedia : 77 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Related Diseases for Lichen Sclerosus

Diseases related to Lichen Sclerosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 lichen planus 30.9 COL17A1 GZMB TP53
2 discoid lupus erythematosus 30.4 GZMB HLA-DRB1
3 graft-versus-host disease 30.2 GZMB HLA-DQB1 HLA-DRB1
4 autoimmune disease 30.1 COL17A1 HLA-DQB1 HLA-DRB1
5 bullous pemphigoid 30.0 COL17A1 HLA-DQB1 HLA-DRB1
6 lichen sclerosus et atrophicus 12.9
7 balanitis xerotica obliterans 12.3
8 squamous cell carcinoma 10.9
9 localized scleroderma 10.8
10 vulva squamous cell carcinoma 10.6
11 balanitis 10.5
12 phimosis 10.5
13 leukoplakia of penis 10.5
14 urethral stricture 10.5
15 melanoma 10.4
16 vulvar intraepithelial neoplasia 10.4
17 vitiligo-associated multiple autoimmune disease susceptibility 1 10.4
18 lupus erythematosus 10.4
19 penile cancer, adult 10.4
20 hepatitis 10.3
21 fasciitis 10.3
22 biliary cirrhosis, primary, 1 10.3
23 breast cancer 10.3
24 granuloma annulare 10.3
25 primary biliary cirrhosis 10.3
26 systemic scleroderma 10.3
27 primary biliary cholangitis 10.3
28 rapidly involuting congenital hemangioma 10.3
29 ige responsiveness, atopic 10.2
30 pityriasis rubra pilaris 10.2
31 scleroderma, familial progressive 10.2
32 eosinophilic fasciitis 10.2
33 mycosis fungoides 10.2
34 sexual disorder 10.2
35 dermatomyositis 10.2
36 hepatitis c 10.2
37 vulvar melanoma 10.2
38 dermatitis 10.2
39 thyroiditis 10.2
40 psoriasis 10.2
41 chronic graft versus host disease 10.2
42 degos 'en cocarde' erythrokeratoderma 10.2
43 leukoplakia 10.2
44 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
45 papillon-lefevre syndrome 10.2 GZMB HLA-DRB1
46 narcolepsy 2 10.2 HLA-DQB1 HLA-DRB1
47 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
48 necrotizing sialometaplasia 10.2 GZMB TP53
49 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
50 metal allergy 10.2 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to Lichen Sclerosus

Symptoms & Phenotypes for Lichen Sclerosus

Drugs & Therapeutics for Lichen Sclerosus

Drugs for Lichen Sclerosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Zinc Approved, Investigational Phase 4 7440-66-6 32051
3 insulin Phase 4
4 Hypoglycemic Agents Phase 4
5 Insulin, Globin Zinc Phase 4
6
Clobetasol Approved, Experimental, Investigational Phase 3,Phase 2,Not Applicable 25122-46-7, 25122-41-2 5311051 32798
7 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
8 Hormones Phase 3,Phase 2,Not Applicable
9 glucocorticoids Phase 3,Phase 2,Not Applicable
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
11 Hormone Antagonists Phase 3,Phase 2,Not Applicable
12
Tacrolimus Approved, Investigational Phase 2 104987-11-3 6473866 445643 439492
13
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 17753757 6447131
14
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
15
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
16
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
17 Immunosuppressive Agents Phase 2,Not Applicable
18 Immunologic Factors Phase 2,Not Applicable
19 Calcineurin Inhibitors Phase 2
20 Antirheumatic Agents Phase 2
21 Dermatologic Agents Phase 2,Not Applicable
22 Peripheral Nervous System Agents Phase 2
23 Analgesics, Non-Narcotic Phase 2
24 Analgesics Phase 2
25 Anti-Inflammatory Agents, Non-Steroidal Phase 2
26 Antipruritics Phase 2
27 Hydrocortisone 17-butyrate 21-propionate Phase 2
28 Hydrocortisone hemisuccinate Phase 2
29 Hydrocortisone-17-butyrate Phase 2
30 Progestins Phase 2
31
Methylene blue Approved, Investigational Phase 1,Not Applicable 61-73-4
32
Ropivacaine Approved Phase 1 84057-95-4 175805 71273
33
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
34
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
35 BB 1101 Phase 1
36
Petrolatum Approved, Investigational Not Applicable 8009-03-8
37
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
38
Betamethasone Approved, Vet_approved Not Applicable 378-44-9 9782
39
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
40
Cortisone Experimental Not Applicable 53-06-5 222786
41 Emollients Not Applicable
42 Triamcinolone hexacetonide Not Applicable
43 retinol Not Applicable
44 Retinol palmitate Not Applicable
45 Triamcinolone diacetate Not Applicable
46 triamcinolone acetonide Not Applicable
47 Estrogens Not Applicable
48 Acidophilus Not Applicable
49 Anti-Asthmatic Agents Not Applicable
50 Betamethasone benzoate Not Applicable

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
2 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3 Clobetasol Propionate 0.05% ointment
3 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2 Tacrolimus cream;Clobetasol cream
4 Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus Completed NCT00393263 Phase 2 pimecrolimus and clobetasol;clobetasol 0.05% cream
5 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
6 Evaluation of Vulvar Lichen Sclerosus Treatment Using Adipose Tissue Associated With Autologous Platelet-rich Plasma. Active, not recruiting NCT03961126 Phase 2 Injection of autologous fatty tissue associated with autologous platelet-rich plasma.;Corticosteroids (clobetasol 0.05%)
7 Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus Terminated NCT01126255 Phase 2 Clobetasol propionate 0.05%;Progesterone 8%
8 Methylene Blue Injection for Nonneoplastic Epithelial Disorders of Vulva Active, not recruiting NCT03200808 Phase 1 mixed methylene blue compound injection
9 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Unknown status NCT02732145
10 Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Completed NCT03045172 Not Applicable Placebo
11 The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients Completed NCT03686800 Not Applicable
12 Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus Completed NCT02794363 Not Applicable
13 Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser Completed NCT02416531 Not Applicable Clobetasol propionate
14 Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus Completed NCT01400022 Not Applicable
15 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable
16 MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus Recruiting NCT03665584 Not Applicable
17 Biomarkers of Lichen Sclerosus Recruiting NCT03561428
18 Lichen Sclerosus - the Influence on Quality of Life Recruiting NCT03419377 Not Applicable
19 Vulvar Scarring Grading Scale for Lichen Sclerosus Active, not recruiting NCT02880904
20 Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Active, not recruiting NCT03063684 Not Applicable
21 Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus Active, not recruiting NCT03525522 Not Applicable Topical corticosteroid Diprosone
22 Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen) Active, not recruiting NCT02761122 Not Applicable
23 Vulvar Mucosal Specialty Clinic Chart Review Active, not recruiting NCT02881229
24 Clinical Trial to Demonstrate That the Dual Laser Therapy is Effective for the Treatment of Vulvar Lichen Sclerosus Not yet recruiting NCT03926299 Not Applicable Clobetasol propionate 0.05% ointment
25 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Lichen Sclerosus

Genetic Tests for Lichen Sclerosus

Anatomical Context for Lichen Sclerosus

MalaCards organs/tissues related to Lichen Sclerosus:

42
Skin, T Cells, Thyroid, Breast, Bone, Endothelial, Bone Marrow

Publications for Lichen Sclerosus

Articles related to Lichen Sclerosus:

(show top 50) (show all 1157)
# Title Authors Year
1
Lichen sclerosus et atrophicus and allergic contact dermatitis: A significant association. ( 30864217 )
2019
2
Adolescent Vulvar Angiokeratoma Associated with Lichen Sclerosus. ( 30974213 )
2019
3
Vulvar basal cell carcinoma in a patient with long-standing lichen sclerosus. ( 30560190 )
2019
4
Preputial lichen sclerosus: a rare and easily ignored initial clinical presentation of newly diagnosed diabetes mellitus. ( 30600354 )
2019
5
Paediatric vulval lichen sclerosus: a retrospective study. ( 30623460 )
2019
6
A Randomized Double-Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus. ( 30639885 )
2019
7
Should We Always Biopsy in Clinically Evident Lichen Sclerosus? ( 30688761 )
2019
8
Introital Obliteration as a Consequence of Lichen Sclerosus. ( 30772315 )
2019
9
Living with vulval lichen sclerosus: a systematic review. ( 30791096 )
2019
10
Insights into the Pathophysiology of Urethral Stricture Disease Due to Lichen Sclerosus: Comparison of Pathological Markers in Lichen Sclerosus Induced Strictures vs Nonlichen Sclerosus Induced Strictures. ( 30835614 )
2019
11
Re: Urethral Lichen Sclerosus under the Microscope: A Survey of Academic Pathologists. ( 30835616 )
2019
12
Acrochordon With Histological Features of Lichen Sclerosus. ( 30946102 )
2019
13
Efficacy of Non-ablative Laser Therapy for Lichen Sclerosus: A Randomized Controlled Trial. ( 30981618 )
2019
14
Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation. ( 30991399 )
2019
15
Lichen Sclerosus on the Sites of Striae Distensae and a Surgical Scar in a Patient with Coexistent Morphea. ( 31032793 )
2019
16
Oral lichen sclerosus: a rare case and update. ( 31046906 )
2019
17
Acral Bullous Lichen Sclerosus Intolerant to UVA-1 Successfully Treated With Narrowband Ultraviolet B Phototherapy. ( 31062884 )
2019
18
Vulvar Squamous Cell Carcinoma in a Patient With Vulvar Lichen Sclerosus. ( 31066866 )
2019
19
Management of Vulval Lichen Sclerosus-The Role of the Plastic Surgeon. ( 31080544 )
2019
20
Therapeutic monitoring of male genital lichen sclerosus: usefulness of reflectance confocal microscopy. ( 31104459 )
2019
21
Extragenital Lichen Sclerosus Induced by Radiotherapy. ( 29566881 )
2019
22
Lichen sclerosus associated with Nd:YAG laser therapy. ( 29856231 )
2019
23
Incidence of vulval squamous cell carcinoma in women with vulval lichen sclerosus in an Australian tertiary referral centre. ( 29932211 )
2019
24
An original exploration of genital lichen sclerosus: the semantic connectivity map. ( 30051519 )
2019
25
The use of PRP (platelet-rich plasma) in patients affected by genital lichen sclerosus: clinical analysis and results. ( 30051614 )
2019
26
Cushing Syndrome Induced by Topical Corticosteroids for the Treatment of Lichen Sclerosus. ( 30244192 )
2019
27
Mucinous Metaplasia of the Vulva in Zoon Vulvitis and Lichen Sclerosus et Atrophicus. Description of 3 Additional Cases of a Rarely Reported Histopathologic Finding. ( 30252696 )
2019
28
Fact or Fiction? Adipose-Derived Stem Cells and Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus. ( 30252710 )
2019
29
Nivolumab PD-1 inhibitor immunotherapy associated with vulvar, perineal and perianal lichen sclerosus. ( 30430637 )
2019
30
Lichen sclerosus et atrophicus diagnosed in a child accompanied with local periodontal attachment loss and maxillary deficiency: A rare case report. ( 30467890 )
2019
31
Future research priorities for lichen sclerosus - results of a James Lind Alliance Priority Setting Partnership. ( 30472735 )
2019
32
Surgical management of genitourinary lichen sclerosus et atrophicus in boys in England: A 10-year review of practices and outcomes. ( 30482498 )
2019
33
Association of Vulvar Melanoma with Lichen Sclerosus. ( 30521058 )
2019
34
Continuous Spatial Sequences of Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Invasive Carcinomas: A Study of 109 Cases. ( 30614356 )
2019
35
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
36
A case of Bullous Pemphigoid Associated with Lichen Sclerosus et Atrophicus. ( 30210168 )
2018
37
Eosinophilic fasciitis and lichen sclerosus in a patient treated with nivolumab. ( 29797309 )
2018
38
Association between Helicobacter pylori infection and vulvar lichen sclerosus: a clinical comparative study. ( 29336317 )
2018
39
Staged Urethroplasty for Penile Urethral Strictures From Lichen Sclerosus and Failed Hypospadias Repair. ( 29107132 )
2018
40
Vulval lichen planus-lichen sclerosus overlap. ( 29490571 )
2018
41
Evaluation of the effectiveness of treatment of vulvar lichen sclerosus et atrophicus. Analysis of own material and review of the literature. ( 30664348 )
2018
42
Benign Atrophic Papulosis (Degos Disease) With Lymphocytic Vasculitis and Lichen Sclerosus-Like Features. ( 28244939 )
2018
43
Vulvar lichen sclerosus in women is associated with lower urinary tract symptoms. ( 28593367 )
2018
44
The possible role of human papillomavirus infection in the development of lichen sclerosus. ( 28737238 )
2018
45
The diagnosis and management of male genital lichen sclerosus: a retrospective review of 301 patients. ( 28750140 )
2018
46
Mometasone furoate in the treatment of vulvar lichen sclerosus: could its formulation influence efficacy, tolerability and adherence to treatment? ( 28753097 )
2018
47
Clearance in vulvar lichen sclerosus: a realistic treatment endpoint or a chimera? ( 28796915 )
2018
48
Folliculocentric hyperkeratotic lichen sclerosus in a 7-year-old child successfully treated with narrowband ultraviolet B phototherapy. ( 28940561 )
2018
49
A survey on the use of topical steroids in patients treated for lichen sclerosus-associated vulval squamous cell carcinoma. ( 29017363 )
2018
50
Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination. ( 29025691 )
2018

Variations for Lichen Sclerosus

Expression for Lichen Sclerosus

Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for Lichen Sclerosus

GO Terms for Lichen Sclerosus

Cellular components related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.5 COL17A1 ECM1 ELN
2 endocytic vesicle membrane GO:0030666 9.43 HLA-DQB1 HLA-DRB1
3 collagen-containing extracellular matrix GO:0062023 9.43 COL17A1 ECM1 ELN
4 ER to Golgi transport vesicle membrane GO:0012507 9.4 HLA-DQB1 HLA-DRB1
5 transport vesicle membrane GO:0030658 9.37 HLA-DQB1 HLA-DRB1
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
8 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.54 CD44 COL17A1 ELN
2 antigen processing and presentation GO:0019882 9.43 HLA-DQB1 HLA-DRB1
3 protein tetramerization GO:0051262 9.4 HLA-DRB1 TP53
4 interferon-gamma-mediated signaling pathway GO:0060333 9.33 CD44 HLA-DQB1 HLA-DRB1
5 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.32 GZMB TP53
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
8 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQB1 HLA-DRB1
2 extracellular matrix structural constituent GO:0005201 9.13 COL17A1 ECM1 ELN
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Lichen Sclerosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....