MCID: LCH009
MIFTS: 46

Lichen Sclerosus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lichen Sclerosus

MalaCards integrated aliases for Lichen Sclerosus:

Name: Lichen Sclerosus 54 56
Lichen Sclerosus Et Atrophicus 54 74
Lichen Sclerosis Et Atrophicus 54
Lichen Sclerosis 54

Classifications:



External Ids:

UMLS 74 C0023652

Summaries for Lichen Sclerosus

NIH Rare Diseases : 54 Lichen sclerosus is a chronic skin disorder that is more common in women, most often affecting the external part of the vagina (vulva) or the area around the anus. In men, it typically affects the tip of the penis. It can occur at any age but is usually seen in women over age 50. Some people have no symptoms, while others may experience itchiness (sometimes severe), discomfort, or blistering. It often lasts for years and can cause permanent scarring. The underlying cause of lichen sclerosus is not fully understood but it is thought to relate to an autoimmune process. Treatment may include topical steroids or other types of topical creams and/or surgery.

MalaCards based summary : Lichen Sclerosus, also known as lichen sclerosus et atrophicus, is related to discoid lupus erythematosus and graft-versus-host disease. An important gene associated with Lichen Sclerosus is ECM1 (Extracellular Matrix Protein 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Phospholipase-C Pathway. The drugs Insulin glulisine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Related Diseases for Lichen Sclerosus

Diseases related to Lichen Sclerosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 discoid lupus erythematosus 30.3 GZMB HLA-DRB1
2 graft-versus-host disease 30.2 GZMB HLA-DQB1 HLA-DRB1
3 autoimmune disease 30.1 HLA-DQB1 HLA-DRB1 IL2RA
4 multiple sclerosis 29.7 HLA-DQB1 HLA-DRB1 IL2RA
5 alopecia areata 29.6 GZMB IL2RA
6 lichen sclerosus et atrophicus 12.9
7 balanitis xerotica obliterans 12.2
8 squamous cell carcinoma 10.8
9 lichen planus 10.7
10 localized scleroderma 10.7
11 vulva squamous cell carcinoma 10.6
12 balanitis 10.5
13 urethral stricture 10.5
14 phimosis 10.5
15 leukoplakia of penis 10.5
16 melanoma 10.4
17 vulvar intraepithelial neoplasia 10.4
18 lupus erythematosus 10.3
19 penile cancer, adult 10.3
20 hepatitis 10.3
21 fasciitis 10.3
22 biliary cirrhosis, primary, 1 10.3
23 breast cancer 10.3
24 granuloma annulare 10.3
25 primary biliary cirrhosis 10.3
26 primary biliary cholangitis 10.3
27 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
28 narcolepsy 2 10.2 HLA-DQB1 HLA-DRB1
29 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
30 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
31 metal allergy 10.2 HLA-DQB1 HLA-DRB1
32 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
33 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
34 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
35 narcolepsy 1 10.2 HLA-DQB1 HLA-DRB1
36 scleroderma, familial progressive 10.2
37 eosinophilic fasciitis 10.2
38 mycosis fungoides 10.2
39 sexual disorder 10.2
40 dermatomyositis 10.2
41 hepatitis c 10.2
42 vulvar melanoma 10.2
43 dermatitis 10.2
44 thyroiditis 10.2
45 bullous pemphigoid 10.2
46 psoriasis 10.2
47 chronic graft versus host disease 10.2
48 degos 'en cocarde' erythrokeratoderma 10.2
49 leukoplakia 10.2
50 rapidly involuting congenital hemangioma 10.2

Graphical network of the top 20 diseases related to Lichen Sclerosus:



Diseases related to Lichen Sclerosus

Symptoms & Phenotypes for Lichen Sclerosus

GenomeRNAi Phenotypes related to Lichen Sclerosus according to GeneCards Suite gene sharing:

27 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.83 IL2RA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.83 HLA-DRB1 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.83 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.83 IL2RA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.83 HLA-DRB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.83 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.83 TP53
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.83 HLA-DRB1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.83 IL2RA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.83 HLA-DRB1 IL2RA TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.83 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.83 HLA-DRB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.83 HLA-DRB1 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.83 IL2RA TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.83 TP53
16 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.83 HLA-DRB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.83 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.83 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.83 IL2RA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.83 TP53
21 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.83 TP53
22 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.83 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.83 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.83 IL2RA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.83 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.83 HLA-DRB1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.83 IL2RA

Drugs & Therapeutics for Lichen Sclerosus

Drugs for Lichen Sclerosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Zinc Approved, Investigational Phase 4 7440-66-6 32051
3 Hypoglycemic Agents Phase 4
4 Insulin, Globin Zinc Phase 4
5 insulin Phase 4
6
Clobetasol Approved, Experimental, Investigational Phase 3,Phase 2,Not Applicable 25122-46-7, 25122-41-2 32798 5311051
7 Hormone Antagonists Phase 3,Phase 2,Not Applicable
8 glucocorticoids Phase 3,Phase 2,Not Applicable
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
10 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
11 Hormones Phase 3,Phase 2,Not Applicable
12
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492 6473866
13
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 17753757 6447131
14
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
15
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
16
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
17 Immunosuppressive Agents Phase 2,Not Applicable
18 Calcineurin Inhibitors Phase 2
19 Immunologic Factors Phase 2,Not Applicable
20 Analgesics Phase 2
21 Analgesics, Non-Narcotic Phase 2
22 Antirheumatic Agents Phase 2
23 Dermatologic Agents Phase 2,Not Applicable
24 Peripheral Nervous System Agents Phase 2
25 Anti-Inflammatory Agents, Non-Steroidal Phase 2
26 Hydrocortisone-17-butyrate Phase 2
27 Hydrocortisone 17-butyrate 21-propionate Phase 2
28 Antipruritics Phase 2
29 Hydrocortisone hemisuccinate Phase 2
30 Progestins Phase 2
31
Methylene blue Approved, Investigational Phase 1,Not Applicable 61-73-4
32
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
33
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
34
Ropivacaine Approved Phase 1 84057-95-4 71273 175805
35 BB 1101 Phase 1
36
Petrolatum Approved, Investigational Not Applicable 8009-03-8
37
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
38
Betamethasone Approved, Vet_approved Not Applicable 378-44-9 9782
39
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
40
Cortisone Experimental Not Applicable 53-06-5 222786
41 Emollients Not Applicable
42 Triamcinolone diacetate Not Applicable
43 triamcinolone acetonide Not Applicable
44 Triamcinolone hexacetonide Not Applicable
45 Retinol palmitate Not Applicable
46 retinol Not Applicable
47 Acidophilus Not Applicable
48 Estrogens Not Applicable
49 Betamethasone Valerate Not Applicable 2152-44-5
50 Respiratory System Agents Not Applicable

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
2 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3 Clobetasol Propionate 0.05% ointment
3 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2 Tacrolimus cream;Clobetasol cream
4 Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus Completed NCT00393263 Phase 2 pimecrolimus and clobetasol;clobetasol 0.05% cream
5 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
6 Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus Terminated NCT01126255 Phase 2 Clobetasol propionate 0.05%;Progesterone 8%
7 Methylene Blue Injection for Nonneoplastic Epithelial Disorders of Vulva Active, not recruiting NCT03200808 Phase 1 mixed methylene blue compound injection
8 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Unknown status NCT02732145
9 Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Completed NCT03045172 Not Applicable Placebo
10 The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients Completed NCT03686800 Not Applicable
11 Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus Completed NCT02794363 Not Applicable
12 Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser Completed NCT02416531 Not Applicable Clobetasol propionate
13 Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus Completed NCT01400022 Not Applicable
14 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable
15 MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus Recruiting NCT03665584 Not Applicable
16 Biomarkers of Lichen Sclerosus Recruiting NCT03561428
17 Lichen Sclerosus - the Influence on Quality of Life Recruiting NCT03419377 Not Applicable
18 Vulvar Scarring Grading Scale for Lichen Sclerosus Active, not recruiting NCT02880904
19 Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Active, not recruiting NCT03063684 Not Applicable
20 Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus Active, not recruiting NCT03525522 Not Applicable Topical corticosteroid Diprosone
21 Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen) Active, not recruiting NCT02761122 Not Applicable
22 Vulvar Mucosal Specialty Clinic Chart Review Active, not recruiting NCT02881229
23 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Lichen Sclerosus

Genetic Tests for Lichen Sclerosus

Anatomical Context for Lichen Sclerosus

MalaCards organs/tissues related to Lichen Sclerosus:

42
Skin, T Cells, Breast, Thyroid, Bone, Endothelial, Bone Marrow

Publications for Lichen Sclerosus

Articles related to Lichen Sclerosus:

(show top 50) (show all 1144)
# Title Authors Year
1
Lichen sclerosus et atrophicus and allergic contact dermatitis: A significant association. ( 30864217 )
2019
2
Vulvar basal cell carcinoma in a patient with long-standing lichen sclerosus. ( 30560190 )
2019
3
Preputial lichen sclerosus: a rare and easily ignored initial clinical presentation of newly diagnosed diabetes mellitus. ( 30600354 )
2019
4
Cushing Syndrome Induced by Topical Corticosteroids for the Treatment of Lichen Sclerosus. ( 30244192 )
2019
5
Continuous Spatial Sequences of Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Invasive Carcinomas: A Study of 109 Cases. ( 30614356 )
2019
6
Paediatric vulval lichen sclerosus: a retrospective study. ( 30623460 )
2019
7
A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. ( 30639885 )
2019
8
Should We Always Biopsy in Clinically Evident Lichen Sclerosus? ( 30688761 )
2019
9
Introital Obliteration as a Consequence of Lichen Sclerosus. ( 30772315 )
2019
10
Living with vulval lichen sclerosus: a systematic review. ( 30791096 )
2019
11
Insights into the pathophysiology of urethral stricture disease due to lichen sclerosus: comparison of pathologic markers in lichen sclerosus induced strictures versus non-lichen sclerosus induced strictures. ( 30835614 )
2019
12
Re: Urethral Lichen Sclerosus under the Microscope: A Survey of Academic Pathologists. ( 30835616 )
2019
13
Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination. ( 29025691 )
2018
14
Platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus in a premenopausal woman: A case report. ( 29785390 )
2018
15
Association of Retinoic Acid Receptor I^ Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma. ( 29898214 )
2018
16
Blue diode laser: a new strategy for the management of lichen sclerosus et atrophicus. ( 29564880 )
2018
17
Lichen sclerosus in pregnancy: A review of 33 cases. ( 29920642 )
2018
18
Lichen sclerosus on the face. ( 29399776 )
2018
19
Genital Lichen Sclerosus Et Atrophicus: A Benign Skin Disorder With Malignant Aftermath. ( 29729359 )
2018
20
A case of radiation-induced bullous morphea/lichen sclerosus overlap in a breast cancer patient. ( 29872368 )
2018
21
Gender differences in genital lichen sclerosus. ( 29368855 )
2018
22
Vitiligoid variant of lichen sclerosus in young girls with darker skin types. ( 29314207 )
2018
23
Oral lichen sclerosus: a systematic review of reported cases and two new cases. ( 29313955 )
2018
24
Eosinophilic fasciitis and lichen sclerosus in a patient treated with nivolumab. ( 29797309 )
2018
25
Association between Helicobacter pylori infection and vulvar lichen sclerosus: a clinical comparative study. ( 29336317 )
2018
26
Lichen sclerosus of the oral mucosa: clinical and histopathological findings. Review of the literature and a case report. ( 29658796 )
2018
27
Concomitant morphea and lichen sclerosus et atrophicus in the same plaque at the site of intramuscular drug injection: an interesting case presentation. ( 29945269 )
2018
28
Routine histopathological examination of the foreskin after circumcision for clinically suspected Lichen sclerosus in children: Is it a waste of resources? ( 29405913 )
2018
29
British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. ( 29313888 )
2018
30
Lichen Sclerosus Accompanied by Urethral Squamous Cell Carcinoma: A Retrospective Study From a Urethral Referral Center. ( 29926751 )
2018
31
Lichen sclerosus associated with Nd:YAG laser therapy. ( 29856231 )
2018
32
Linear orofacial lichen sclerosus. ( 29405132 )
2018
33
Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. ( 29505429 )
2018
34
Updates in lichen sclerosis: British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. ( 29668094 )
2018
35
Urethral lichen sclerosus under the microscope: a survey of academic pathologists. ( 29900821 )
2018
36
Incidence of vulval squamous cell carcinoma in women with vulval lichen sclerosus in an Australian tertiary referral centre. ( 29932211 )
2018
37
Photodynamic Therapy for Vulvar Lichen Sclerosus-A Systematic Review. ( 29271859 )
2018
38
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
39
Bullous lichen sclerosus: isolated vulvar involvement. ( 29630161 )
2018
40
Squamous Cell Carcinoma of the Bulbar Urethra Accompanied by Lichen Sclerosus: A Case Report. ( 29182032 )
2018
41
Extragenital Lichen Sclerosus Induced by Radiotherapy. ( 29566881 )
2018
42
Prospective evaluation of frequency of genital lichen sclerosus in 79 patients with systemic sclerosis. ( 29928761 )
2018
43
Oral lichen sclerosus: an overview and report of three cases. ( 29705404 )
2018
44
Penile Lichen Sclerosus Treated with 1927a88nm Thulium Fiber Laser and Photodynamic Therapy: A New Possible Therapeutic Approach. ( 29298401 )
2018
45
Balanopreputial Adhesion and Paraphimosis due to Lichen Sclerosus. ( 29853765 )
2018
46
Lichen Sclerosus of the Upper Lip: Report of a Case, Utilizing Shikata's Modified Orcein Stain, and Review of the Literature. ( 29707184 )
2018
47
Asymptomatic hyperkeratotic plaque on the vulva of a patient with lichen sclerosus. ( 29424084 )
2018
48
A case of Bullous Pemphigoid Associated with Lichen Sclerosus et Atrophicus. ( 30210168 )
2018
49
Staged Urethroplasty for Penile Urethral Strictures From Lichen Sclerosus and Failed Hypospadias Repair. ( 29107132 )
2018
50
Vulval lichen planus-lichen sclerosus overlap. ( 29490571 )
2018

Variations for Lichen Sclerosus

Expression for Lichen Sclerosus

Search GEO for disease gene expression data for Lichen Sclerosus.

Pathways for Lichen Sclerosus

Pathways related to Lichen Sclerosus according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 CD44 HLA-DQB1 HLA-DRB1 IL2RA TP53
2
Show member pathways
12.7 ECM1 ELN IL2RA TP53
3
Show member pathways
12.5 GZMB HLA-DQB1 HLA-DRB1 IL2RA
4
Show member pathways
12.32 HLA-DQB1 HLA-DRB1 IL2RA
5
Show member pathways
12.27 HLA-DQB1 HLA-DRB1 IL2RA
6 12.24 CD44 GZMB IL2RA
7
Show member pathways
12.19 CD44 HLA-DQB1 HLA-DRB1
8
Show member pathways
12.15 HLA-DQB1 HLA-DRB1 IL2RA TP53
9
Show member pathways
12.05 HLA-DQB1 HLA-DRB1 IL2RA
10 11.8 HLA-DQB1 HLA-DRB1 IL2RA TP53
11
Show member pathways
11.55 GZMB HLA-DRB1 IL2RA
12 11.4 HLA-DQB1 HLA-DRB1
13
Show member pathways
11.36 GZMB IL2RA
14 11.34 CD44 GZMB IL2RA
15 11.24 CD44 TP53
16 11.21 HLA-DQB1 HLA-DRB1 TP53
17 10.92 HLA-DRB1 IL2RA
18 10.91 CD44 HLA-DQB1 HLA-DRB1 IL2RA
19 10.72 CD44 ECM1 ELN

GO Terms for Lichen Sclerosus

Cellular components related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
2 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
3 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
5 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.65 ELN IL2RA TP53
2 antigen processing and presentation GO:0019882 9.46 HLA-DQB1 HLA-DRB1
3 negative regulation of T cell proliferation GO:0042130 9.43 HLA-DRB1 IL2RA
4 protein tetramerization GO:0051262 9.4 HLA-DRB1 TP53
5 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.37 GZMB TP53
6 interferon-gamma-mediated signaling pathway GO:0060333 9.33 CD44 HLA-DQB1 HLA-DRB1
7 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.32 HLA-DQB1 HLA-DRB1
8 inflammatory response to antigenic stimulus GO:0002437 9.26 HLA-DRB1 IL2RA
9 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
10 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Lichen Sclerosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Lichen Sclerosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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