Lichen Sclerosus Et Atrophicus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Lichen sclerosus (LS) affects the skin leading to scarring around the genital and anal areas. It mainly affects the skin around the vagina, anus, and tip of the penis. Symptoms can include white lesions or plaques, pain during urination, itching, and pain during intercourse. Some people have no symptoms, while others may experience itchiness (sometimes severe), discomfort, or blistering. The underlying cause of Lichen sclerosus is not known, but it is thought to relate to an autoimmune process. Diagnosis is based on the symptoms and clinical exam. A skin biopsy may be done to confirm the diagnosis.

MalaCards based summary: Lichen Sclerosus Et Atrophicus, also known as lichen sclerosus, is related to phimosis and fungal infectious disease. An important gene associated with Lichen Sclerosus Et Atrophicus is ECM1 (Extracellular Matrix Protein 1), and among its related pathways/superpathways are NF-kappaB Signaling and Innate Lymphoid Cells Differentiation. The drugs Petrolatum and Clobetasol have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related phenotypes are squamous cell carcinoma and carcinoma

Wikipedia: ⁷⁵ Lichen sclerosus (LS) is a chronic, inflammatory skin disease of unknown cause which can affect any body... more...

More information from OMIM: 151590

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Related Diseases for Lichen Sclerosus Et Atrophicus

Diseases related to Lichen Sclerosus Et Atrophicus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 406)

#	Related Disease	Score	Top Affiliating Genes
1	phimosis	31.0	ELN ECM1
2	fungal infectious disease	30.8	TLR4 MYD88 CD8A
3	primary biliary cholangitis	30.8	TLR4 GZMB CD8A
4	filarial elephantiasis	30.6	TLR4 CD8A
5	viral infectious disease	30.2	TLR4 MYD88 GZMB
6	panniculitis	30.1	TIA1 GZMB CD8A
7	celiac disease 1	29.9	TLR4 TIA1 MYD88 GZMB CD8A
8	anogenital venereal wart	29.9	TLR4 MYD88 CD8A
9	erysipelas	29.7	ELN CD8A
10	connective tissue disease	29.6	TLR4 MYD88 ELN CD8A CD44
11	skin disease	29.3	TLR4 MYD88 GZMB ELN ECM1 CD8A
12	lipoprotein quantitative trait locus	29.2	TLR4 MYD88 ELN CD8A
13	localized scleroderma	11.1
14	systemic scleroderma	10.9
15	vulva squamous cell carcinoma	10.8
16	balanitis xerotica obliterans	10.8
17	lichen planus	10.8
18	balanitis	10.8
19	urethral stricture	10.7
20	vitiligo-associated multiple autoimmune disease susceptibility 6	10.7
21	vitiligo-associated multiple autoimmune disease susceptibility 1	10.7
22	penile cancer	10.7
23	lyme disease	10.6
24	leukoplakia	10.6
25	acrodermatitis	10.6
26	penile benign neoplasm	10.6
27	malignant tumor of penis	10.6
28	mycosis fungoides	10.6
29	graft-versus-host disease	10.6
30	acrodermatitis chronica atrophicans	10.6
31	vulva cancer	10.6
32	liver cirrhosis	10.6
33	penis squamous cell carcinoma	10.6
34	penile cancer, adult	10.6
35	rapidly involuting congenital hemangioma	10.5
36	systemic lupus erythematosus	10.5
37	systemic lupus erythematosus 1	10.5
38	balanoposthitis	10.5
39	lupus erythematosus	10.5
40	alopecia	10.5
41	chronic graft versus host disease	10.5
42	dilution, pigmentary	10.4
43	dermatitis, atopic	10.4
44	basal cell carcinoma 1	10.4
45	keratosis	10.4
46	melanoma	10.4
47	basal cell carcinoma	10.4
48	dermatitis	10.4
49	skin atrophy	10.4
50	contact dermatitis	10.4

Graphical network of the top 20 diseases related to Lichen Sclerosus Et Atrophicus:

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Symptoms & Phenotypes for Lichen Sclerosus Et Atrophicus

Human phenotypes related to Lichen Sclerosus Et Atrophicus:

³⁰

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	squamous cell carcinoma ³⁰			HP:0002860
2	carcinoma ³⁰			HP:0030731

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 08-Dec-2022)

Skin:
lichen sclerosus et atrophicus
ivory-colored, polygonal, flat-topped lichenoid papules
papules may coalesce into atrophic plaques

Oncology:
vulvar lsa may predispose to squamous cell carcinoma

Clinical features from OMIM®:

151590 (Updated 08-Dec-2022)

MGI Mouse Phenotypes related to Lichen Sclerosus Et Atrophicus:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.76	CD44 CD8A ECM1 GZMB MYD88 RARB
2	renal/urinary system	MP:0005367	9.73	CD44 CD8A HMBS MYD88 RARB TLR4
3	hematopoietic system	MP:0005397	9.61	CD44 CD8A ECM1 GZMB HMBS MYD88
4	mortality/aging	MP:0010768	9.32	CD44 CD8A ECM1 ELN GZMB HMBS

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Drugs & Therapeutics for Lichen Sclerosus Et Atrophicus

Drugs for Lichen Sclerosus Et Atrophicus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Petrolatum

Approved, Investigational

Phase 4

8009-03-8

2

Clobetasol

Approved, Experimental, Investigational

Phase 3

25122-46-7, 25122-41-2

2791 5311051 32798

3

Dermatologic Agents

Phase 3

4

Emollients

Phase 3

5

Hormones

Phase 3

6

Hormone Antagonists

Phase 3

7

glucocorticoids

Phase 3

8

Anti-Inflammatory Agents

Phase 3

9

Mitogens

Phase 3

10

Tacrolimus

Approved, Investigational

Phase 2

104987-11-3

6473866 445643

11

Pimecrolimus

Approved, Investigational

Phase 2

137071-32-0

17753757 6509979

12

Progesterone

Approved, Vet_approved

Phase 2

57-83-0

5994

13

Calcineurin Inhibitors

Phase 2

14

Immunosuppressive Agents

Phase 2

15

Immunologic Factors

Phase 2

16

Antirheumatic Agents

Phase 2

17

Anti-Inflammatory Agents, Non-Steroidal

Phase 2

18

Analgesics, Non-Narcotic

Phase 2

19

Analgesics

Phase 2

20

Progestins

Phase 2

21

Betamethasone

Approved, Vet_approved

378-44-9

9782

22

Methylene blue

Approved, Investigational

61-73-4

6099

23

Ethanol

Approved

64-17-5

702

24

Aminolevulinic acid

Approved

106-60-5

137

25

Mometasone furoate

Approved, Investigational, Vet_approved

83919-23-7

4240 441336

26

Cortisone

Experimental

53-06-5

222786

27

Anti-Asthmatic Agents

28

Betamethasone-17,21-dipropionate

29

Betamethasone Valerate

2152-44-5

30

Betamethasone sodium phosphate

31

Betamethasone benzoate

32

Respiratory System Agents

33

Estrogens

34

Acidophilus

35

Lidocaine, Prilocaine Drug Combination

36

Anesthetics, Local

37

Anesthetics

38

Anti-Allergic Agents

39

Photosensitizing Agents

Interventional clinical trials:

(show all 39)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Controlled Trial of Vulvar Fractionated CO2-Laser Therapy With and Without Concomitant Topical Clobetasol Propionate 0.05% Ointment for Treatment of Vulvar Lichen Sclerosus	Active, not recruiting	NCT04951206	Phase 4	Clobetasol Propionate 0.05% Ointment
2	A Randomized Trial of Clobetasol Propionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus (CuRLS)	Completed	NCT02573883	Phase 3	Clobetasol Propionate 0.05% ointment
3	A Randomized, Unblinded Trial of Topical Steroids Plus CO2 Laser Compared to Steroids Alone in the Treatment of Vulvovaginal Lichen Sclerosus	Recruiting	NCT05243563	Phase 2, Phase 3	Topical steroid
4	CO2 Non-ablative Laser Versus Topical Clobetasol for Lichen Sclerosus: a Prospective, Open-label, Randomized Trial	Recruiting	NCT05010421	Phase 3	Clobetasol 0.05% Emollient Top Cream
5	Randomized Clinical Trial, Controlled to Conventional Treatment, to Evaluate the Efficacy of Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the Vulva	Not yet recruiting	NCT05364515	Phase 3	PRGF;Clobetasol Propionate
6	A Double Blind Phase II Study Comparing Safety and Efficacy of Tacrolimus Versus Topical Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus.	Completed	NCT00757874	Phase 2	Tacrolimus cream;Clobetasol cream
7	A Double-Blind, Parallel-group Trial of Topical Pimecrolimus Cream 1% (Elidel®) Versus Clobetasol 0.05% Cream for the Treatment of Vulvar Lichen Sclerosus	Completed	NCT00393263	Phase 2	pimecrolimus and clobetasol;clobetasol 0.05% cream
8	Pilot Study of Vulvar Lichen Sclerosus (VLS) Treatment Using Adipose Tissue Associated With Autologous Platelet-rich Plasma (PRP).	Completed	NCT03961126	Phase 2	Injection of autologous fatty tissue associated with autologous platelet-rich plasma.;Corticosteroids (clobetasol 0.05%)
9	A Pilot, Randomized, Blinded, Controlled Study Evaluating Autologous Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus	Recruiting	NCT04967170	Phase 1, Phase 2
10	A Phase 2, Randomized, Double-Blind, Vehicle-Controlled, Study of the Efficacy and Safety of Ruxolitinib Cream in Participants With Lichen Sclerosus	Not yet recruiting	NCT05593445	Phase 2	Ruxolitinib cream;Vehicle cream
11	Efficacy of a Topic Therapy With Progesterone Compared to the Conventional Therapy With Clobetasol Propionate in Patients With Vulvar Lichen Sclerosus. A Double Blind, Randomized Phase II Pilot Study.	Terminated	NCT01126255	Phase 2	Clobetasol propionate 0.05%;Progesterone 8%
12	Efficacy of Nd:Yttrium Aluminum Garnet Laser Treatment of Lichen Sclerosus	Unknown status	NCT03525522		Topical corticosteroid Diprosone
13	Safety and Efficacy of Er:YAG and Nd:YAG Laser Therapy in Gynecology: A Retrospective Case Series.	Unknown status	NCT04073082
14	Discovery and Validation of Biomarkers of Lichen Sclerosus	Unknown status	NCT03561428
15	Low-Level Laser Therapy: an Efficient Supplement to Treatments of Vulvar Lichen Sclerosus to Improve Quality of Life	Completed	NCT05060224
16	Clinical Study of the CO2RE® Laser Device for Treatment of Vulvar Lichen Sclerosus	Completed	NCT04148651
17	The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients	Completed	NCT03686800
18	Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus	Completed	NCT03063684
19	Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis	Completed	NCT02732145
20	Autologous Platelet Rich Plasma Intradermal Injections for Vulvar Lichen Sclerosus	Completed	NCT02794363
21	A Double Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma (PRP) Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus	Completed	NCT03045172		Placebo
22	Lichen Sclerosus - the Influence on Quality of Life	Completed	NCT03419377
23	A Double Blinded Sham Controlled Trial of Fractional CO2 Laser Treatment Using the DEKA SmartXide Touch Laser System (MonaLisa Touch) for the Treatment of Vulvar Lichen Sclerosus	Completed	NCT03665584
24	Efficacy and Safety of the Neodymium Laser in Treatment of Urogenital Tract Diseases in Women	Completed	NCT05251220
25	Vulvar Lichen Sclerosus: Therapeutic Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser	Completed	NCT02416531		Clobetasol propionate
26	Characterizing the Microbiome in Postmenopausal Women With Vulvar Lichen Sclerosus	Completed	NCT05147129
27	A Randomized Clinical Study Comparing Topical 0.05% Clobetasol Propianate in Vaseline With UVA-1 Phototherapy in the Treatment of Vulvar Lichen Sclerosus	Completed	NCT01400022
28	Post-marketing Surveillance of a Flexible Wound Dressing for the Management of Genital Skin Conditions	Completed	NCT05396261
29	Laser Therapy in Women With Lichenoid Disorders: A Randomized Controlled Trial	Recruiting	NCT04697563
30	A Comparative Study on the Efficacy of AI Temperature-controlled Radiofrequency Technology and Electrical Stimulation in the Treatment of Vulvar Leukoplakia	Recruiting	NCT05250466
31	Safety and Efficacy of Carbon Dioxide（CO2）Fractional Laser Combined With Photodynamic Therapy in the Treatment of Female Vulvar Lichen Sclerosus	Recruiting	NCT05228483		Mometasone furoate (MMF) 0.1% ointment
32	Nonfat Grafting in Male and Female Genital Lichen Sclerosus	Recruiting	NCT05464290
33	Effect of Treatment With the Ablative Fractional Carbodioxide Laser in Vulvar Lichen Sclerosis	Active, not recruiting	NCT04107454
34	Prospective, Randomized, Active-controlled Investigator Initiated Clinical Trial to Demonstrate That the Nd:YAG/Er:YAG Dual Laser Therapy is Effective to Treat Vulvar Lichen Sclerosus and Similar to Standard Treatment With Steroid Cream	Active, not recruiting	NCT03926299		Clobetasol propionate 0.05% ointment
35	Effectiveness of Ablative Fractional 2940 nm Laser Treatment for Vulvar Lichen Sclerosus	Active, not recruiting	NCT04134494
36	Early Detection of Vulval CAncer Through Self-Examination (EDuCATE): Intervention Study A Feasibility Study of Interventions to Promote Vulval Self-examination in Women at Increased Risk of Vulval Cancer	Not yet recruiting	NCT04952961
37	Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease	Suspended	NCT02223975
38	Development of a Vulvar Scarring Grading Scale for Lichen Sclerosus	Terminated	NCT02880904
39	Open Ended Chart Review of Adult Women Presenting to the Vulvar Mucosal Specialty Clinic at Northwestern University Department of Dermatology	Terminated	NCT02881229

Search NIH Clinical Center for Lichen Sclerosus Et Atrophicus

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Genetic Tests for Lichen Sclerosus Et Atrophicus

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Anatomical Context for Lichen Sclerosus Et Atrophicus

Organs/tissues related to Lichen Sclerosus Et Atrophicus:

MalaCards : Skin, T Cells, Breast, Bone Marrow, Thyroid, Lymph Node, Smooth Muscle

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Publications for Lichen Sclerosus Et Atrophicus

Articles related to Lichen Sclerosus Et Atrophicus:

(show top 50) (show all 2508)

#	Title	Authors	PMID	Year
1	Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. ⁵³ ⁶² ⁵⁷	Oyama N...McGrath JA	12867112	2003
2	Interleukin 1 receptor antagonist gene polymorphism association with lichen sclerosus. ⁶² ⁵⁷	Clay FE...Duff GW	7927338	1994
3	Familial occurrence of lichen sclerosus et atrophicus. Case reports of a mother and daughter. ⁶² ⁵⁷	Shirer JA...Ray MC	3827280	1987
4	Genetic aspects of vulvar lichen sclerosus. ⁶² ⁵⁷	Friedrich EG...MacLaren NK	6591797	1984
5	Downregulated CD44 and hyaluronan expression in vulvar intraepithelial neoplasia and squamous cell carcinomas. ⁵³ ⁶²	Hamalainen K...Anttila M	19900133	2010
6	A case of lichen sclerosus of the scalp associated with autoantibodies to extracellular matrix protein 1. ⁵³ ⁶²	Kawakami Y...Yamamoto T	20026864	2009
7	CD44 and hyaluronate expression in follicular mucinosis. ⁵³ ⁶²	Kaya G...Saurat JH	16466510	2006
8	Three-dimensional imaging reveals major changes in skin microvasculature in lipoid proteinosis and lichen sclerosus. ⁵³ ⁶²	Kowalewski C...McGrath JA	15927815	2005
9	Restored epidermal CD44 expression in lichen sclerosus et atrophicus and clinical improvement with topical application of retinaldehyde. ⁵³ ⁶²	Kaya G...Saurat JH	15787834	2005
10	Characterization of IgG autoantibodies to extracellular matrix protein 1 in lichen sclerosus. ⁵³ ⁶²	Chan I...McGrath JA	15347336	2004
11	Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus. ⁵³ ⁶²	Oyama N...McGrath JA	15173881	2004
12	Translational benefits from research on rare genodermatoses. ⁵³ ⁶²	McGrath JA	15068453	2004
13	The role of extracellular matrix protein 1 in human skin. ⁵³ ⁶²	Chan I	14723723	2004
14	Alterations in fibrillin as well as collagens I and III and elastin occur in vulval lichen sclerosus. ⁵³ ⁶²	Farrell AM...Wojnarowska F	11683283	2001
15	Decrease in epidermal CD44 expression as a potential mechanism for abnormal hyaluronate accumulation in superficial dermis in lichen sclerosus et atrophicus. ⁵³ ⁶²	Kaya G...Saurat JH	11121141	2000
16	Expression of retinoic acid receptors in non-neoplastic epithelial disorders of the vulva and normal vulvar skin. ⁵³ ⁶²	Berger J...Zeimet AG	10782404	2000
17	The Evolving Landscape of Viral, Immune, and Molecular Biomarkers in Penile Cancer. ⁶²	Yu A...Spiess PE	36424078	2023
18	Self-disgust in Patients with Dermatological Diseases. ⁶²	Schienle A...Wabnegger A	35113320	2022
19	Therapeutic potential of adipose tissue-derivatives in modern dermatology. ⁶²	Bellei B...Picardo M	35102608	2022
20	Platelet rich plasma for the management of urogynecological disorders: the current evidence. ⁶²	Prodromidou A...Athanasiou S	36036461	2022
21	Laser Therapy for Recalcitrant Vulvar Lichen Sclerosus: A Review of the Literature. ⁶²	Marnach ML...Casey PM	35385852	2022
22	Living with vulval lichen sclerosus: a qualitative interview study. ⁶²	Arnold S...Rees S	35831927	2022
23	Understanding the impact of life with vulval lichen sclerosus. ⁶²	Sivalingam V...Tamber K	36052748	2022
24	Lichen sclerosus in female patients is associated with an increased risk of metabolic syndrome and cardiovascular comorbidities: a retrospective cohort review. ⁶²	Ranum A...Pearson DR	35947535	2022
25	Association of vulvar lichen sclerosus with endometrial and ovarian cancer. ⁶²	Ganesan AK...Kraus CN	36034745	2022
26	Lichen Sclerosus throughout Childhood and Adolescence: Not Only a Premenarchal Disease. ⁶²	Winfrey OK...Quint EH	36038010	2022
27	Differential proteomic expression in indolent vulvar lichen sclerosus, transforming vulvar lichen sclerosus and normal vulvar tissue. ⁶²	Gleue CA...Lehman JS	35960231	2022
28	Reflectance Confocal Microscopy for Identification of Vulvar Lichen Sclerosus et Atrophicus and Vitiligo. ⁶²	Gu J...Zou Y	36395443	2022
29	Lichen Sclerosus and Sexual Dysfunction: A Systematic Review and Meta-Analysis. ⁶²	Pope R...Shin JI	36115787	2022
30	Pediatric and Adolescent Gynecology - a Current Overview. ⁶²	Gunther V...Alkatout I	36420782	2022
31	Acquired Elastotic Hemangioma-like Change of the Vulva Associated With Lichen Sclerosus. ⁶²	Val-Bernal JF...Aller L	34593702	2022
32	Vulvar dermatoses: a cross-sectional 5-year study. Experience in a specialized vulvar unit. ⁶²	Garcia-Souto F...Bernabeu-Wittel J	36089549	2022
33	High-frequency ultrasound features in vulvar lichen sclerosus and correlation with histopathology. ⁶²	Zhou MY...Liu J	35969183	2022
34	Extragenital lichen sclerosus: A comprehensive review. ⁶²	Arif T...Sami M	35950883	2022
35	The Importance of Immunological Disorders in the Pathogenesis of Lichen Sclerosus in Pediatric Patients: A Systematic Review. ⁶²	Torres A...Grywalska E	36430687	2022
36	Why do some patients with vulval lichen sclerosus on long-term topical corticosteroid treatment experience ongoing poor quality of life? ⁶²	Wijaya M...Fischer G	36208206	2022
37	Linear morphea with overlying lichen sclerosus and calcinosis cutis associated with juvenile dermatomyositis. ⁶²	Kaur M...Alam A	36384242	2022
38	[Pediatric genital lichen sclerosus: a case series of 11 girls]. ⁶²	Arostegui Aguilar J...Yanguas JI	36408571	2022
39	Characterization of patients with vulvar lichen sclerosus and association to vulvar carcinoma: a retrospective single center analysis. ⁶²	Steinkasserer L...Jentschke M	36409332	2022
40	Does Clearance of Vulvar Lichen Sclerosus after a Corticosteroid Treatment Correspond to a Decrease in Disease-Related Burden? Results from a Cohort Study Using Pictorial Representation of Illness and Self-Measure and the Dermatology Life Quality Index. ⁶²	Borghi A...Corazza M	36382657	2022
41	In vivo evaluation of vulvar lichen sclerosus with reflectance confocal microscopy and therapeutic monitoring in children. ⁶²	Chen L...Li Q	36380494	2022
42	Reflectance confocal microscopy for non-invasive diagnosis of childhood-onset vulvar lichen sclerosus: A retrospective study. ⁶²	Jiang Q...Chen L	36433788	2022
43	Thyroid disorders associated with lichen sclerosus: a case-control study in the All of Us Research Program. ⁶²	Fan R...Little AJ	35661997	2022
44	Clinical and histopathological spectrum of genital lichen sclerosus in 133 cases: Focus on the diagnosis of pre-sclerotic disease. ⁶²	Attili VR...Attili SK	35389022	2022
45	Autologous Fat Grafting: Evaluation of Efficacy in Pain Relief. ⁶²	Klomparens K...Simman R	36337431	2022
46	Quality of life impact and treatment response in vulval disease: Comparison of 3 common conditions using the Vulval Quality of Life Index. ⁶²	Wu M...Fischer G	35932464	2022
47	Tumor necrosis factor-α inhibitor-induced morphea and psoriasiform dermatitis in a pediatric patient with Crohn's disease. ⁶²	Reinhart JP...Tollefson MM	36385392	2022
48	Genital Self-Image, Sexual Function, and Quality of Life Among Individuals with Vulvar and Non-Vulvar Inflammatory Dermatoses. ⁶²	Rivera S...DeMaria AL	35900677	2022
49	Evaluation of risk in chronic cutaneous inflammatory conditions for malignant transformation. ⁶²	Ju T...Nouri K	36251409	2022
50	Pentoxifylline in dermatology. ⁶²	Balazic E...Kobets K	36208009	2022

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Genes for Lichen Sclerosus Et Atrophicus

Genes related to Lichen Sclerosus Et Atrophicus (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ECM1	Extracellular Matrix Protein 1	Protein Coding	10.46	Novoseek inferred ⁵³	12867112 15173881 15927815 (more) 15347336 14723723 20026864 15068453
2	GZMB	Granzyme B	Protein Coding	8.97	GeneCards inferred via : Publications (show sections)
3	TIA1	TIA1 Cytotoxic Granule Associated RNA Binding Protein	Protein Coding	8.86	GeneCards inferred via : Publications (show sections)
4	CD8A	CD8a Molecule	Protein Coding	8.52	GeneCards inferred via : Publications (show sections)
5	HMBS	Hydroxymethylbilane Synthase	Protein Coding	8.52	GeneCards inferred via : Publications (show sections)
6	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	8.52	GeneCards inferred via : Publications (show sections)
7	TLR4	Toll Like Receptor 4	Protein Coding	8.52	GeneCards inferred via : Publications (show sections)
8	TRPM8	Transient Receptor Potential Cation Channel Subfamily M Member 8	Protein Coding	8.52	GeneCards inferred via : Publications (show sections)
9	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	5.77	Novoseek inferred ⁵³	11121141 19900133 15787834 (more) 16466510
10	ELN	Elastin	Protein Coding	4.13	Novoseek inferred ⁵³	11683283
11	RARB	Retinoic Acid Receptor Beta	Protein Coding	3.28	Novoseek inferred ⁵³	10782404

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Variations for Lichen Sclerosus Et Atrophicus

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Expression for Lichen Sclerosus Et Atrophicus

Search GEO for disease gene expression data for Lichen Sclerosus Et Atrophicus.

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Pathways for Lichen Sclerosus Et Atrophicus

Pathways related to Lichen Sclerosus Et Atrophicus according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ³	12.14	MYD88 GZMB CD8A CD44
2	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	GZMB CD8A CD44
3	Burn wound healing ⁷⁴	11.21	TLR4 MYD88 ELN
4	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.04	TLR4 MYD88
5	miRNAs involvement in the immune response in sepsis ⁷⁴	10.92	TLR4 MYD88 GZMB
6	IL-10 Pathway ⁶⁴	10.91	TLR4 TIA1
7	Cell adhesion_Cell-matrix glycoconjugates ²²	10.39	ELN ECM1 CD44

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GO Terms for Lichen Sclerosus Et Atrophicus

Biological processes related to Lichen Sclerosus Et Atrophicus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of macrophage cytokine production	GO:0060907	9.62	TLR4 MYD88
2	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.56	TLR4 MYD88
3	positive regulation of NLRP3 inflammasome complex assembly	GO:1900227	9.46	TLR4 MYD88
4	cellular response to oxidised low-density lipoprotein particle stimulus	GO:0140052	9.26	TLR4 MYD88
5	positive regulation of lymphocyte proliferation	GO:0050671	8.8	TLR4 MYD88

Sources

Sources for Lichen Sclerosus Et Atrophicus

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

LSA MCID: LCH016 MIFTS: 47	Lichen Sclerosus Et Atrophicus (LSA) Categories: Rare diseases, Reproductive diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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Lichen Sclerosus Et Atrophicus (LSA)

Aliases & Classifications for Lichen Sclerosus Et Atrophicus

MalaCards integrated aliases for Lichen Sclerosus Et Atrophicus:

Characteristics:

Inheritance:

Classifications:

External Ids:

Summaries for Lichen Sclerosus Et Atrophicus

Related Diseases for Lichen Sclerosus Et Atrophicus

Diseases related to Lichen Sclerosus Et Atrophicus via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Lichen Sclerosus Et Atrophicus:

Symptoms & Phenotypes for Lichen Sclerosus Et Atrophicus

Human phenotypes related to Lichen Sclerosus Et Atrophicus:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

MGI Mouse Phenotypes related to Lichen Sclerosus Et Atrophicus:

Drugs & Therapeutics for Lichen Sclerosus Et Atrophicus

Drugs for Lichen Sclerosus Et Atrophicus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

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Genetic Tests for Lichen Sclerosus Et Atrophicus

Anatomical Context for Lichen Sclerosus Et Atrophicus

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Genes for Lichen Sclerosus Et Atrophicus

Genes related to Lichen Sclerosus Et Atrophicus (0 elite genes):

Variations for Lichen Sclerosus Et Atrophicus

Expression for Lichen Sclerosus Et Atrophicus

Pathways for Lichen Sclerosus Et Atrophicus

Pathways related to Lichen Sclerosus Et Atrophicus according to GeneCards Suite gene sharing:

GO Terms for Lichen Sclerosus Et Atrophicus

Biological processes related to Lichen Sclerosus Et Atrophicus according to GeneCards Suite gene sharing:

Sources for Lichen Sclerosus Et Atrophicus