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MCID: LCH016
MIFTS: 35

Lichen Sclerosus Et Atrophicus

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lichen Sclerosus Et Atrophicus

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MalaCards integrated aliases for Lichen Sclerosus Et Atrophicus:

Name: Lichen Sclerosus Et Atrophicus 57 76 73
Lsa 57 76

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
lichen sclerosus et atrophicus:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 57 151590
MedGen 42 C0023652
ICD10 33 L90.0
SNOMED-CT via HPO 69 263681008 28899001 402815007
UMLS 73 C0023652
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Summaries for Lichen Sclerosus Et Atrophicus

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MalaCards based summary : Lichen Sclerosus Et Atrophicus, also known as lsa, is related to cutaneous t cell lymphoma and mycosis fungoides. An important gene associated with Lichen Sclerosus Et Atrophicus is GZMB (Granzyme B), and among its related pathways/superpathways are Apoptosis and Autophagy and IL12-mediated signaling events. The drugs Insulin glulisine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related phenotype is squamous cell carcinoma.

Wikipedia : 76 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Description from OMIM: 151590
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Related Diseases for Lichen Sclerosus Et Atrophicus

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Diseases related to Lichen Sclerosus Et Atrophicus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 cutaneous t cell lymphoma 29.6 GZMB TIA1
2 mycosis fungoides 29.3 GZMB TIA1
3 lichen sclerosus 12.1
4 squamous cell carcinoma 10.5
5 phimosis 10.4
6 lichen planus 10.4
7 graft-versus-host disease 10.3
8 burns 10.3
9 hepatitis 10.3
10 balanitis 10.3
11 balanitis xerotica obliterans 10.3
12 leukoplakia of penis 10.3
13 chronic graft versus host disease 10.3
14 orbit lymphoma 10.2 GZMB TIA1
15 lymphomatoid granulomatosis 10.2 GZMB TIA1
16 viral esophagitis 10.2 GZMB TIA1
17 lymphocytic gastritis 10.2 GZMB TIA1
18 subcutaneous panniculitis-like t-cell lymphoma 10.2 GZMB TIA1
19 primary cutaneous anaplastic large cell lymphoma 10.1 GZMB TIA1
20 natural killer cell leukemia 10.1 GZMB TIA1
21 composite lymphoma 10.1 GZMB TIA1
22 hepatosplenic t-cell lymphoma 10.1 GZMB TIA1
23 ainhum 10.1
24 systemic lupus erythematosus 10.1
25 pemphigus vulgaris, familial 10.1
26 rheumatoid arthritis 10.1
27 temporal arteritis 10.1
28 celiac disease 1 10.1
29 leukemia, chronic myeloid 10.1
30 alopecia 10.1
31 arthritis 10.1
32 burn scar 10.1
33 granuloma annulare 10.1
34 leukemia 10.1
35 pemphigus vulgaris 10.1
36 lymphoma 10.1
37 hypospadias 10.1
38 keratosis 10.1
39 vulvar disease 10.1
40 elephantiasis 10.1
41 periodontitis 10.1
42 influenza 10.1
43 herpes zoster 10.1
44 lichen nitidus 10.1
45 lupus erythematosus 10.1
46 pemphigus 10.1
47 alopecia areata 10.1
48 penile cancer, adult 10.1
49 pityriasis lichenoides 10.1
50 lymphomatoid papulosis 10.1 GZMB TIA1

Graphical network of the top 20 diseases related to Lichen Sclerosus Et Atrophicus:



Diseases related to Lichen Sclerosus Et Atrophicus
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Symptoms & Phenotypes for Lichen Sclerosus Et Atrophicus

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Symptoms via clinical synopsis from OMIM:

57
Skin:
lichen sclerosus et atrophicus
ivory-colored, polygonal, flat-topped lichenoid papules
papules may coalesce into atrophic plaques

Oncology:
vulvar lsa may predispose to squamous cell carcinoma


Clinical features from OMIM:

151590

Human phenotypes related to Lichen Sclerosus Et Atrophicus:

32
# Description HPO Frequency HPO Source Accession
1 squamous cell carcinoma 32 HP:0002860
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Drugs & Therapeutics for Lichen Sclerosus Et Atrophicus

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Drugs for Lichen Sclerosus Et Atrophicus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Zinc Approved, Investigational Phase 4 7440-66-6 23994
3 Hypoglycemic Agents Phase 4
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4
6
Clobetasol Approved, Investigational Phase 3,Phase 2,Not Applicable 25122-46-7, 25122-41-2 32798 5311051
7 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
8 glucocorticoids Phase 3,Phase 2,Not Applicable
9 Hormone Antagonists Phase 3,Phase 2,Not Applicable
10 Hormones Phase 3,Phase 2,Not Applicable
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
12
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
13
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
14
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
15
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
16
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
17 Calcineurin Inhibitors Phase 2
18 Immunosuppressive Agents Phase 2,Not Applicable
19 Analgesics Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 2
22 Antirheumatic Agents Phase 2
23 Dermatologic Agents Phase 2,Not Applicable
24 Peripheral Nervous System Agents Phase 2
25 Antipruritics Phase 2
26 Cortisol succinate Phase 2
27 Hydrocortisone 17-butyrate 21-propionate Phase 2
28 Hydrocortisone acetate Phase 2
29 Hydrocortisone-17-butyrate Phase 2
30 Progestins Phase 2
31
Methylene blue Approved, Investigational Phase 1,Not Applicable 61-73-4
32
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
33
Ropivacaine Approved Phase 1 84057-95-4 71273 175805
34 BB 1101 Phase 1
35 Dexamethasone acetate Phase 1 1177-87-3
36
Cortisone acetate Approved, Investigational Not Applicable 1950-04-4, 50-04-4 5745
37
Petrolatum Approved, Investigational Not Applicable 8009-03-8
38
Menthol Approved Not Applicable 2216-51-5 16666
39
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
40
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
41
Cortisone Not Applicable 53-06-5 222786
42 Emollients Not Applicable
43 Estrogens Not Applicable
44 Retinol palmitate Not Applicable
45 triamcinolone acetonide Not Applicable
46 Triamcinolone diacetate Not Applicable
47 Triamcinolone hexacetonide Not Applicable
48 Acidophilus Nutraceutical Not Applicable
49 retinol Nutraceutical Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
2 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3 Clobetasol Propionate 0.05% ointment
3 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2 Tacrolimus cream;Clobetasol cream
4 Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus Completed NCT00393263 Phase 2 pimecrolimus and clobetasol;clobetasol 0.05% cream
5 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
6 Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus Terminated NCT01126255 Phase 2 Clobetasol propionate 0.05%;Progesterone 8%
7 Methylene Blue Injection for Nonneoplastic Epithelial Disorders of Vulva Active, not recruiting NCT03200808 Phase 1 mixed methylene blue compound injection
8 Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus Completed NCT02794363 Not Applicable
9 Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser Completed NCT02416531 Not Applicable Clobetasol propionate
10 Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus Completed NCT01400022 Not Applicable
11 Biomarkers of Lichen Sclerosus Recruiting NCT03561428
12 Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Recruiting NCT03063684 Not Applicable
13 Lichen Sclerosus - the Influence on Quality of Life Recruiting NCT03419377 Not Applicable
14 Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen) Recruiting NCT02761122 Not Applicable
15 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145
16 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995 Not Applicable
17 Vulvar Scarring Grading Scale for Lichen Sclerosus Active, not recruiting NCT02880904
18 Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Active, not recruiting NCT03045172 Not Applicable Saline
19 Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus Active, not recruiting NCT03525522 Not Applicable Topical corticosteroid Diprosone
20 Vulvar Mucosal Specialty Clinic Chart Review Active, not recruiting NCT02881229
21 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Lichen Sclerosus Et Atrophicus

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Genetic Tests for Lichen Sclerosus Et Atrophicus

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Anatomical Context for Lichen Sclerosus Et Atrophicus

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MalaCards organs/tissues related to Lichen Sclerosus Et Atrophicus:

41
Skin, T Cells
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Publications for Lichen Sclerosus Et Atrophicus

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Articles related to Lichen Sclerosus Et Atrophicus:

(show top 50) (show all 119)
# Title Authors Year
1
Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination. ( 29025691 )
2018
2
Blue diode laser: a new strategy for the management of lichen sclerosus et atrophicus. ( 29564880 )
2018
3
Genital Lichen Sclerosus Et Atrophicus: A Benign Skin Disorder With Malignant Aftermath. ( 29729359 )
2018
4
Concomitant morphea and lichen sclerosus et atrophicus in the same plaque at the site of intramuscular drug injection: an interesting case presentation. ( 29945269 )
2018
5
5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: series of ten cases. ( 29258952 )
2017
6
Lichen sclerosus et atrophicus: atypical case simulating lichen planus. ( 28633743 )
2017
7
Extragenital lichen sclerosus et atrophicus co-exististing with pemphigus vulgaris. ( 28217480 )
2017
8
Penile Melanosis Associated with Lichen Sclerosus et Atrophicus: First Description in the Medical Literature. ( 28932316 )
2017
9
Diagnostic criteria, severity classification and guideline of lichen sclerosus et atrophicus. ( 29265410 )
2017
10
Postirradiation Lichen Sclerosus et Atrophicus. ( 28538963 )
2017
11
Vulvar Lichen Sclerosus et Atrophicus. ( 28706405 )
2017
12
Lichen sclerosus et atrophicus in a surgical scar treated with fractional laser. ( 27911123 )
2016
13
Folliculocentric Lichen Sclerosus et Atrophicus in a 10-Year-Old Girl. ( 27415635 )
2016
14
Effects of Intravenous Ketamine Infusions in a Neuropathic Pain Patient with Lichen Sclerosus et Atrophicus. ( 27462225 )
2016
15
Extensive bullous lichen sclerosus et atrophicus. ( 28300903 )
2016
16
Extra genital lichen sclerosus et atrophicus with cutaneous distribution and morphology simulating lichen planus. ( 25657434 )
2015
17
A Case of Lichen Sclerosus et Atrophicus With Distinct Erythematous Borders. ( 26054578 )
2015
18
Immunohistochemical Similarities between Lichen Sclerosus et Atrophicus and Morphea: A Case Study. ( 25873875 )
2015
19
Eosinophils in lichen sclerosus et atrophicus. ( 26152335 )
2015
20
Extragenital Lichen Sclerosus et Atrophicus. ( 26288432 )
2015
21
Extragenital lichen sclerosus et atrophicus along the lines of Blaschko. ( 26500867 )
2015
22
Disseminated extragenital lichen sclerosus et atrophicus treated with acitretin. ( 24720089 )
2014
23
Segmental vitiligo and extragenital lichen sclerosus et atrophicus simultaneously occurring on the opposite sides of the abdomen. ( 25473235 )
2014
24
Lichen sclerosus et atrophicus in males: how to diagnose, how to manage... ( 25364811 )
2014
25
The co-occurrence of lichen sclerosus et atrophicus and celiac disease. ( 25593796 )
2014
26
Lichen sclerosus et atrophicus. ( 24365005 )
2013
27
Isolated, localised extragenital bullous lichen sclerosus et atrophicus: a rare entity. ( 24082218 )
2013
28
Acute urinary retention in an adolescent as the presenting symptom of lichen sclerosus et atrophicus. ( 23726137 )
2013
29
Lichen sclerosus et atrophicus induced by carbamazepine: a case report. ( 24067479 )
2013
30
Penile pseudo-ainhum associated with lichen sclerosus et atrophicus. ( 24195101 )
2013
31
A case of cutaneous lichen sclerosus et atrophicus effectively treated by extracorporeal photochemotherapy. ( 23651276 )
2013
32
Oral lichen sclerosus et atrophicus - literature review and two clinical cases. ( 24436952 )
2013
33
Topical TRPM8 agonist (icilin) relieved vulva pruritus originating from lichen sclerosus et atrophicus. ( 22042233 )
2012
34
Photodynamic therapy of vulvar lichen sclerosus et atrophicus in a woman with hypothyreosis--case report. ( 22594990 )
2012
35
Perifollicular papules and hyperkeratotic plaques on the back in a blaschkoid distribution. Morphea with features of lichen sclerosus et atrophicus (LS). ( 21768488 )
2011
36
Acral lichen sclerosus et atrophicus--case report. ( 22068779 )
2011
37
Coexistence of generalized morphea and lichen sclerosus et atrophicus mimicking systemic disease. ( 21548525 )
2011
38
A case of lichen sclerosus et atrophicus accompanying bullous morphea. ( 22346277 )
2011
39
Development of lichen sclerosus et atrophicus while receiving a therapeutic dose of imatinib mesylate for chronic myelogenous leukemia. ( 19703239 )
2010
40
Folliculocentric lichen sclerosus et atrophicus. ( 21137615 )
2010
41
Bilateral zosteriform extragenital lichen sclerosus et atrophicus: a new clinical presentation. ( 20536655 )
2010
42
An unusual presentation of lichen sclerosus et atrophicus in a tattoo. ( 19758382 )
2010
43
Lichen sclerosus et atrophicus-like skin lesions in a patient carrying a novel hydroxymethylbilane synthase mutation. ( 20580577 )
2010
44
Extragenital lichen sclerosus et atrophicus mimicking cutaneous T-cell lymphoma: report of a case. ( 19903217 )
2010
45
Lichen Sclerosus et Atrophicus with Cutaneous Distribution Simulating Lichen Planus. ( 21173929 )
2010
46
Rapid onset of squamous cell carcinoma in a short-standing lichen sclerosus et atrophicus of the penis. ( 19323914 )
2009
47
Lichen sclerosus et atrophicus-like graft-versus-host disease post stem cell transplant. ( 19930991 )
2009
48
Lichen sclerosus et atrophicus in pediatric and adult male patients with congenital and acquired phimosis. ( 18660641 )
2008
49
Lichen sclerosus et atrophicus responding to methotrexate. ( 18507666 )
2008
50
Lichen sclerosus et atrophicus of the lip: successful treatment with topical tacrolimus. ( 18031502 )
2008
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Variations for Lichen Sclerosus Et Atrophicus

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Expression for Lichen Sclerosus Et Atrophicus

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Search GEO for disease gene expression data for Lichen Sclerosus Et Atrophicus.
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Pathways for Lichen Sclerosus Et Atrophicus

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Pathways related to Lichen Sclerosus Et Atrophicus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Apoptosis and Autophagy 4
11.52 GZMB TIA1
2
IL12-mediated signaling events 1
Show member pathways
 11.21 CD8A GZMB
3
Innate Lymphoid Cell Differentiation Pathways 65
10.86 CD8A GZMB
4
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 10.41 CD8A GZMB
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GO Terms for Lichen Sclerosus Et Atrophicus

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Sources for Lichen Sclerosus Et Atrophicus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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