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LSA
MCID: LCH016
MIFTS: 33

Lichen Sclerosus Et Atrophicus (LSA)

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lichen Sclerosus Et Atrophicus

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MalaCards integrated aliases for Lichen Sclerosus Et Atrophicus:

Name: Lichen Sclerosus Et Atrophicus 57 76 73
Lsa 57 76

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
lichen sclerosus et atrophicus:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 57 151590
MedGen 42 C0023652
ICD10 33 L90.0
UMLS 73 C0023652
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Summaries for Lichen Sclerosus Et Atrophicus

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MalaCards based summary : Lichen Sclerosus Et Atrophicus, also known as lsa, is related to cutaneous t cell lymphoma and mycosis fungoides. An important gene associated with Lichen Sclerosus Et Atrophicus is GZMB (Granzyme B), and among its related pathways/superpathways are Apoptosis and Autophagy and IL12-mediated signaling events. The drugs Insulin glulisine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and t cells, and related phenotypes are squamous cell carcinoma and carcinoma

Wikipedia : 76 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Description from OMIM: 151590
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Related Diseases for Lichen Sclerosus Et Atrophicus

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Diseases related to Lichen Sclerosus Et Atrophicus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 cutaneous t cell lymphoma 30.2 TIA1 GZMB
2 mycosis fungoides 30.1 TIA1 GZMB
3 lichen sclerosus 12.3
4 localized scleroderma 10.8
5 squamous cell carcinoma 10.7
6 lichen planus 10.7
7 phimosis 10.6
8 biliary cirrhosis, primary, 1 10.5
9 primary biliary cirrhosis 10.5
10 lupus erythematosus 10.5
11 primary biliary cholangitis 10.5
12 graft-versus-host disease 10.5
13 balanitis xerotica obliterans 10.5
14 leukoplakia 10.5
15 aging 10.4
16 systemic lupus erythematosus 10.4
17 hepatitis 10.4
18 balanitis 10.4
19 leukoplakia of penis 10.4
20 chronic graft versus host disease 10.4
21 penile cancer, adult 10.4
22 acanthosis nigricans 10.2
23 ainhum 10.2
24 autoimmune disease 10.2
25 pemphigus vulgaris, familial 10.2
26 rheumatoid arthritis 10.2
27 celiac disease 1 10.2
28 phenylketonuria 10.2
29 basal cell carcinoma 1 10.2
30 leukemia, chronic myeloid 10.2
31 alopecia 10.2
32 arthritis 10.2
33 burn scar 10.2
34 burns 10.2
35 granuloma annulare 10.2
36 pemphigus vulgaris 10.2
37 lymphoma 10.2
38 crest syndrome 10.2
39 dermatomyositis 10.2
40 hypospadias 10.2
41 keratosis 10.2
42 vulvar disease 10.2
43 basal cell carcinoma 10.2
44 purpura 10.2
45 verrucous carcinoma 10.2
46 vulvitis 10.2
47 vulva basal cell carcinoma 10.2
48 elephantiasis 10.2
49 influenza 10.2
50 bullous pemphigoid 10.2

Graphical network of the top 20 diseases related to Lichen Sclerosus Et Atrophicus:



Diseases related to Lichen Sclerosus Et Atrophicus
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Symptoms & Phenotypes for Lichen Sclerosus Et Atrophicus

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Symptoms via clinical synopsis from OMIM:

57
Skin:
lichen sclerosus et atrophicus
ivory-colored, polygonal, flat-topped lichenoid papules
papules may coalesce into atrophic plaques

Oncology:
vulvar lsa may predispose to squamous cell carcinoma


Clinical features from OMIM:

151590

Human phenotypes related to Lichen Sclerosus Et Atrophicus:

32
# Description HPO Frequency HPO Source Accession
1 squamous cell carcinoma 32 HP:0002860
2 carcinoma 32 HP:0030731
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Drugs & Therapeutics for Lichen Sclerosus Et Atrophicus

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Drugs for Lichen Sclerosus Et Atrophicus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Zinc Approved, Investigational Phase 4 7440-66-6
3 Hypoglycemic Agents Phase 4
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4
6
Clobetasol Approved, Experimental, Investigational Phase 3,Phase 2,Not Applicable 25122-46-7, 25122-41-2 5311051 32798
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
8 Hormones Phase 3,Phase 2,Not Applicable
9 Hormone Antagonists Phase 3,Phase 2,Not Applicable
10 glucocorticoids Phase 3,Phase 2,Not Applicable
11 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
12
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
13
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
14
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
15
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
16
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
17 Progestins Phase 2
18 Calcineurin Inhibitors Phase 2
19 Immunologic Factors Phase 2,Not Applicable
20 Immunosuppressive Agents Phase 2,Not Applicable
21 Antirheumatic Agents Phase 2
22 Anti-Inflammatory Agents, Non-Steroidal Phase 2
23 Analgesics Phase 2
24 Peripheral Nervous System Agents Phase 2
25 Analgesics, Non-Narcotic Phase 2
26 Dermatologic Agents Phase 2,Not Applicable
27 Hydrocortisone 17-butyrate 21-propionate Phase 2
28 Hydrocortisone-17-butyrate Phase 2
29 Antipruritics Phase 2
30 Cortisol succinate Phase 2
31
Methylene blue Approved, Investigational Phase 1,Not Applicable 61-73-4
32
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
33
Ropivacaine Approved Phase 1 84057-95-4 175805 71273
34
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
35 BB 1101 Phase 1
36
Betamethasone Approved, Vet_approved Not Applicable 378-44-9 9782
37
Cortisone acetate Approved, Investigational Not Applicable 1950-04-4, 50-04-4 5745
38
Petrolatum Approved, Investigational Not Applicable 8009-03-8
39
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
40
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
41
Cortisone Experimental Not Applicable 53-06-5 222786
42 Anti-Asthmatic Agents Not Applicable
43 Betamethasone benzoate Not Applicable
44 Betamethasone sodium phosphate Not Applicable
45 Betamethasone Valerate Not Applicable 2152-44-5
46 Respiratory System Agents Not Applicable
47 Betamethasone-17,21-dipropionate Not Applicable
48 Acidophilus Not Applicable
49 Estrogens Not Applicable
50 Emollients Not Applicable

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
2 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3 Clobetasol Propionate 0.05% ointment
3 Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus Terminated NCT01126255 Phase 2 Clobetasol propionate 0.05%;Progesterone 8%
4 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2 Tacrolimus cream;Clobetasol cream
5 Clobetasol Versus Pimecrolimus for Vulvar Lichen Sclerosus Completed NCT00393263 Phase 2 pimecrolimus and clobetasol;clobetasol 0.05% cream
6 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
7 Methylene Blue Injection for Nonneoplastic Epithelial Disorders of Vulva Active, not recruiting NCT03200808 Phase 1 mixed methylene blue compound injection
8 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Unknown status NCT02732145
9 Vulvar Scarring Grading Scale for Lichen Sclerosus Active, not recruiting NCT02880904
10 MonaLisa Touch Laser for the Treatment of Vulvar Lichen Sclerosus Recruiting NCT03665584 Not Applicable
11 Biomarkers of Lichen Sclerosus Recruiting NCT03561428
12 Platelet Rich Plasma (PRP) for Vulvar Lichen Sclerosus Completed NCT03045172 Not Applicable Placebo
13 Nd:Yttrium Aluminum Garnet Laser Treatment for Lichen Sclerosus Active, not recruiting NCT03525522 Not Applicable Topical corticosteroid Diprosone
14 The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients Completed NCT03686800 Not Applicable
15 Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Recruiting NCT03063684 Not Applicable
16 Lichen Sclerosus - the Influence on Quality of Life Recruiting NCT03419377 Not Applicable
17 Platelet Rich Plasma Injections for Vulvar Lichen Sclerosus Completed NCT02794363 Not Applicable
18 Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser Completed NCT02416531 Not Applicable Clobetasol propionate
19 Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen Sclerosus Completed NCT01400022 Not Applicable
20 Implication of Human Papillomavirus (HPV) in Lichen Physiopathology in Human (HPVLichen) Active, not recruiting NCT02761122 Not Applicable
21 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975
22 Laser Therapy for Treatment of Urogenital Symptoms in Women Recruiting NCT03681678
23 Vulvar Mucosal Specialty Clinic Chart Review Active, not recruiting NCT02881229
24 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable

Search NIH Clinical Center for Lichen Sclerosus Et Atrophicus

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Genetic Tests for Lichen Sclerosus Et Atrophicus

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Anatomical Context for Lichen Sclerosus Et Atrophicus

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MalaCards organs/tissues related to Lichen Sclerosus Et Atrophicus:

41
Skin, Liver, T Cells, Bone, Testis, B Cells, Myeloid
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Publications for Lichen Sclerosus Et Atrophicus

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Articles related to Lichen Sclerosus Et Atrophicus:

(show top 50) (show all 380)
# Title Authors Year
1
Morphea and Extragenital Lichen Sclerosus et Atrophicus After Influenza Vaccination. ( 29025691 )
2018
2
Blue diode laser: a new strategy for the management of lichen sclerosus et atrophicus. ( 29564880 )
2018
3
Genital Lichen Sclerosus Et Atrophicus: A Benign Skin Disorder With Malignant Aftermath. ( 29729359 )
2018
4
Concomitant morphea and lichen sclerosus et atrophicus in the same plaque at the site of intramuscular drug injection: an interesting case presentation. ( 29945269 )
2018
5
A case of Bullous Pemphigoid Associated with Lichen Sclerosus et Atrophicus. ( 30210168 )
2018
6
Mucinous Metaplasia of the Vulva in Zoon Vulvitis and Lichen Sclerosus et Atrophicus. Description of 3 Additional Cases of a Rarely Reported Histopathologic Finding. ( 30252696 )
2018
7
Extragenital lichen sclerosus et atrophicus within a skin graft scar. ( 30320200 )
2018
8
Lichen sclerosus et atrophicus diagnosed in a child accompanied with local periodontal attachment loss and maxillary deficiency: A rare case report. ( 30467890 )
2018
9
Surgical management of genitourinary lichen sclerosus et atrophicus in boys in England: A 10-year review of practices and outcomes. ( 30482498 )
2018
10
Single aortic branch device: the Mona LSA experience. ( 30001611 )
2018
11
5-Aminolevulinic acid photodynamic therapy in refractory vulvar lichen sclerosus et atrophicus: series of ten cases. ( 29258952 )
2017
12
Lichen sclerosus et atrophicus: atypical case simulating lichen planus. ( 28633743 )
2017
13
Extragenital lichen sclerosus et atrophicus co-exististing with pemphigus vulgaris. ( 28217480 )
2017
14
Penile Melanosis Associated with Lichen Sclerosus et Atrophicus: First Description in the Medical Literature. ( 28932316 )
2017
15
Diagnostic criteria, severity classification and guideline of lichen sclerosus et atrophicus. ( 29265410 )
2017
16
Postirradiation Lichen Sclerosus et Atrophicus. ( 28538963 )
2017
17
Vulvar Lichen Sclerosus et Atrophicus. ( 28706405 )
2017
18
Lichen sclerosus et atrophicus in a surgical scar treated with fractional laser. ( 27911123 )
2016
19
Folliculocentric Lichen Sclerosus et Atrophicus in a 10-Year-Old Girl. ( 27415635 )
2016
20
Effects of Intravenous Ketamine Infusions in a Neuropathic Pain Patient with Lichen Sclerosus et Atrophicus. ( 27462225 )
2016
21
Extensive bullous lichen sclerosus et atrophicus. ( 28300903 )
2016
22
A critical analysis of the internal logic in the Life-Space Assessment (LSA) composite score and suggested solutions. ( 26130658 )
2016
23
Comment on: A critical analysis of the internal logic in the Life-Space Assessment (LSA) composite score and suggested solutions. ( 26545393 )
2016
24
Characterization of a Novel lsa(E)- and lnu(B)-Carrying Structure Located in the Chromosome of a Staphylococcus aureus Sequence Type 398 Strain. ( 26596938 )
2016
25
Response to: Comment on: A critical analysis of the internal logic in the Life-Space Assessment (LSA) composite score and suggested solutions. ( 26659137 )
2016
26
Best Practices and Reality: Can We Do Language Sample Analysis (LSA) Of Children's Natural Conversational Speech Faster and Better Than We Currently Do? The Answer Is YES. ( 27111266 )
2016
27
Study of TCM clinical records based on LSA and LDA SHTDT model. ( 27347051 )
2016
28
Extra genital lichen sclerosus et atrophicus with cutaneous distribution and morphology simulating lichen planus. ( 25657434 )
2015
29
A Case of Lichen Sclerosus et Atrophicus With Distinct Erythematous Borders. ( 26054578 )
2015
30
Immunohistochemical Similarities between Lichen Sclerosus et Atrophicus and Morphea: A Case Study. ( 25873875 )
2015
31
Eosinophils in lichen sclerosus et atrophicus. ( 26152335 )
2015
32
Extragenital Lichen Sclerosus et Atrophicus. ( 26288432 )
2015
33
Extragenital lichen sclerosus et atrophicus along the lines of Blaschko. ( 26500867 )
2015
34
Ga-68-labeled neolactosylated human serum albumin (LSA) for PET imaging of hepatic asialoglycoprotein receptor. ( 25240913 )
2015
35
William Orange CB, MD, FRCP, LSA: A Broadmoor pioneer. ( 25519427 )
2015
36
Presence and new genetic environment of pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in Erysipelothrix rhusiopathiae of swine origin. ( 25759293 )
2015
37
Interlaboratory Comparison of the Results of Lifecodes LSA Class I and Class II Single Antigen Kits for Human Leukocyte Antigen Antibody Detection. ( 25932440 )
2015
38
Novel plasmid-borne multidrug resistance gene cluster including lsa(E) from a linezolid-resistant Enterococcus faecium isolate of swine origin. ( 26324271 )
2015
39
Host specificity in the diversity and transfer of lsa resistance genes in group B Streptococcus. ( 26410170 )
2015
40
Results of the Valiant Mona LSA early feasibility study for descending thoracic aneurysms. ( 26483004 )
2015
41
Disseminated extragenital lichen sclerosus et atrophicus treated with acitretin. ( 24720089 )
2014
42
Segmental vitiligo and extragenital lichen sclerosus et atrophicus simultaneously occurring on the opposite sides of the abdomen. ( 25473235 )
2014
43
Lichen sclerosus et atrophicus in males: how to diagnose, how to manage... ( 25364811 )
2014
44
The co-occurrence of lichen sclerosus et atrophicus and celiac disease. ( 25593796 )
2014
45
Co-existence of Lichen Sclerosus et Atrophicus and Morphoea Along Lines of Blaschko. ( 24470666 )
2014
46
Increase of elastic fibers in lichen sclerosus et atrophicus. ( 24641179 )
2014
47
Presence and genetic environment of pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in enterococci of human and swine origin. ( 24379302 )
2014
48
Spinal cord protection and related complications in endovascular management of B dissection: LSA revascularization and CSF drainage. ( 24967177 )
2014
49
Lichen sclerosus et atrophicus. ( 24365005 )
2013
50
Isolated, localised extragenital bullous lichen sclerosus et atrophicus: a rare entity. ( 24082218 )
2013
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Variations for Lichen Sclerosus Et Atrophicus

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Expression for Lichen Sclerosus Et Atrophicus

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Search GEO for disease gene expression data for Lichen Sclerosus Et Atrophicus.
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Pathways for Lichen Sclerosus Et Atrophicus

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Pathways related to Lichen Sclerosus Et Atrophicus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Apoptosis and Autophagy 4
11.52 GZMB TIA1
2
IL12-mediated signaling events 1
Show member pathways
 11.21 CD8A GZMB
3
Innate Lymphoid Cell Differentiation Pathways 65
10.86 CD8A GZMB
4
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 10.41 CD8A GZMB
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GO Terms for Lichen Sclerosus Et Atrophicus

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Sources for Lichen Sclerosus Et Atrophicus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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