Light Fixation Seizure Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Light Fixation Seizure Syndrome

MalaCards integrated aliases for Light Fixation Seizure Syndrome:

Name: Light Fixation Seizure Syndrome ⁵⁷ ⁷³

M Syndrome ⁵⁷ ⁵⁵

Lfss ⁵⁷

Classifications:

MalaCards categories:
Anatomical: Ear diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the ear and mastoid process

Diseases of inner ear

Disorders of vestibular function

M

External Ids:

OMIM ⁵⁷ 603530

MedGen ⁴² C1863767

ICD10 ³³ H81.0

UMLS ⁷³ C1863767

Sources

Summaries for Light Fixation Seizure Syndrome

MalaCards based summary : Light Fixation Seizure Syndrome, also known as m syndrome, is related to cd40 ligand deficiency and immunodeficiency with hyper-igm, type 1. An important gene associated with Light Fixation Seizure Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways are NF-KappaB Family Pathway and 4-1BB Pathway. The drugs Antibodies and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include b cells, small intestine and lymph node.

Description from OMIM: 603530

Sources

Related Diseases for Light Fixation Seizure Syndrome

Diseases related to Light Fixation Seizure Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)

#	Related Disease	Score	Top Affiliating Genes
1	cd40 ligand deficiency	31.7	CD40 CD40LG
2	immunodeficiency with hyper-igm, type 1	30.8	CD40 CD40LG
3	combined immunodeficiency, x-linked	28.6	CD40 CD40LG
4	charlie m syndrome	12.2
5	three m syndrome 1	12.1
6	three m syndrome 3	12.0
7	three m syndrome 2	12.0
8	immunodeficiency with hyper-igm, type 4	9.8	CD40 CD40LG
9	hyperimmunoglobulin syndrome	9.8	CD40 CD40LG
10	immunodeficiency with hyper-igm, type 3	9.7	CD40 CD40LG
11	exanthema subitum	9.7	CD40 CD40LG
12	waldenstrom macroglobulinemia	9.7	CD40 CD40LG
13	immunodeficiency with hyper-igm, type 2	9.7	CD40 CD40LG
14	mature b-cell neoplasm	9.7	CD40 CD40LG
15	b cell deficiency	9.7	CD40 CD40LG
16	toxoplasmosis	9.7	CD40 CD40LG
17	myocarditis	9.6	CD40 CD40LG
18	immune deficiency disease	9.6	CD40 CD40LG
19	mantle cell lymphoma	9.6	CD40 CD40LG
20	common variable immunodeficiency	9.6	CD40 CD40LG
21	ataxia-telangiectasia	9.5
22	neutropenia	9.5
23	rubella	9.5
24	congenital rubella	9.5
25	myeloma, multiple	9.5	CD40 CD40LG
26	burkitt lymphoma	9.5	CD40 CD40LG
27	lymphoma, non-hodgkin, familial	9.4	CD40 CD40LG
28	lymphoma, mucosa-associated lymphoid type	9.4
29	cyclic neutropenia	9.4
30	cone dystrophy 3	9.4
31	systemic mastocytosis	9.4
32	cone dystrophy	9.4
33	lymphoma	9.4
34	sclerosing cholangitis	9.4
35	histoplasmosis	9.4
36	cholecystitis	9.4
37	acalculous cholecystitis	9.4
38	retinitis	9.4
39	cholangitis	9.4
40	autoimmune disease	9.3	CD40 CD40LG
41	leukemia, chronic lymphocytic	9.2	CD40 CD40LG
42	malaria	9.0	CD40 CD40LG

Graphical network of the top 20 diseases related to Light Fixation Seizure Syndrome:

Sources

Symptoms & Phenotypes for Light Fixation Seizure Syndrome

Clinical features from OMIM:

603530

Sources

Drugs & Therapeutics for Light Fixation Seizure Syndrome

Drugs for Light Fixation Seizure Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Antibodies

Phase 3

2

Immunoglobulin G

Phase 3

3

Immunoglobulins

Phase 3

4

alemtuzumab

Approved, Investigational

Phase 2

216503-57-0

5

Fludarabine

Approved

Phase 2

21679-14-1, 75607-67-9

30751

Synonyms:

(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

21679-14-1

2-F-ara-A

2-F-ARAA

2F-Ara-AMP

2-fluoro ARA-A

2-Fluoro Ara-A

2-Fluoro-9-beta-D-arabinofuranosyladenine

2-Fluoroadenine arabinoside 5'-monophosphate

2-Fluoroadenine arabinoside 5'-monophosphoric acid

2-fluoro-ARA AMP

9 beta-D-Arabinofuranosyl-2-fluoroadenine monophosphate

9-b-Arabinofuranosyl-2-fluoroadenine-5'-phosphate

9-b-Arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid

9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)

9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)

9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate

9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid

9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate

9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid

9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine

9-beta-D-Arabinofuranosyl-2-fluoroadenine

9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)

9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)

9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate

9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid

9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)

9-β-arabinofuranosyl-2-fluoroadenine-5'-phosphate

9-β-arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid

9-β-D-arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)

9-β-D-arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)

9-β-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate

9-β-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid

AC1LCW8I

AC1Q51CF

Beneflur

C10H12FN5O4

CCRIS 3382

CHEMBL1568

CID657237

CPD000058874

D07966

EINECS 244-525-5

FAMP

FaraA

F-Ara-A

FaraAMP

F-Ara-AMP

Fludara

Fludara, Fludarabine

Fludarabina

Fludarabina [Spanish]

Fludarabine

Fludarabine (INN)

Fludarabine [INN]

Fludarabine 5'-monophosphate

Fludarabine 5'-monophosphoric acid

Fludarabine monophosphate

Fludarabine monophosphoric acid

Fludarabine phosphate

Fludarabinum

Fludarabinum [Latin]

Fludura

fluoro-Ara-AMP

Fluradosa

Fluradosa (TN)

FT-0082766

HSDB 6964

I14-4978

LS-15061

MLS000028687

NSC 118218

NSC 118218H

NSC-118218

S1491_Selleck

SAM002548956

SMR000058874

SQ Fludarabine

UNII-1X9VK9O1SC

UNII-P2K93U8740

ZINC04216238

6

Melphalan

Approved

Phase 2

148-82-3

4053 460612

Synonyms:

(2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid

(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

148-82-3

3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine

3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine

3-(P-(Bis(2-chloroethyl)amino)phenyl)-L-alanine

3025 c.b

3025 C.B.

3223-07-2

3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine

3-P-(Di(2-chloroethyl)amino)-phenyl-L-alanine

4-(Bis(2-chloroethyl)amino)-L-phenylalanine

4-(Bis(2-chloroethyl)amino)phenylalanine

4-[Bis(2-chloroethyl)amino]-L-phenylalanine

4-[Bis-(2-chloroethyl)amino]-L-phenylalanine

4-14-00-01689 (Beilstein Handbook Reference)

AC1LA2OE

Alanine Nitrogen Mustard

Alkeran

ALKERAN (TN)

AmbotzHAA1563

At-290

AY3360000

BIDD:GT0044

BRD-K87827419-001-02-8

BRN 2816456

BSPBio_002407

C13H18Cl2N2O2

CB 3025

CB-3025

CCRIS 374

CHEBI:165415

CHEBI:28876

CHEMBL852

CID460612

D00369

DivK1c_000653

EINECS 205-726-3

HMS2090B09

HMS2091B16

HMS502A15

HSDB 3234

IDI1_000653

KBio1_000653

KBio2_000877

KBio2_003445

KBio2_006013

KBio3_001627

KBioGR_001284

KBioSS_000877

L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine

L-3-(P-(Bis(2-chloroethyl)amino)phenyl)alanine

L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine

Levofalan

Levofolan

Levopholan

L-PAM

L-Phenylalanine mustard

LS-15868

LS-865

L-Sarcolysin

L-Sarcolysine

L-Sarkolysin

M2011_SIGMA

Medphalan

Melfalan

Melfalano

Melfalano [INN-Spanish]

melphalan

Melphalan (JP15/USP/INN)

MELPHALAN (SEE ALSO TRANSGENIC MODEL EVALUATION (MELPHALAN))

Melphalan [USAN:INN:BAN:JAN]

Melphalanum

Melphalanum [INN-Latin]

Mephalan

Merphalan

MLS001333666

MLS002153368

MolPort-003-665-535

Mustard, phenylalanine

NCGC00090757-01

NCGC00090757-02

NCGC00090757-03

NCI-C04853

NINDS_000653

NIOSH/AY3360000

NSC 241286

NSC 8806

NSC241286

NSC8806

NSC-8806

P-Bis(b-chloroethyl)aminophenylalanine

p-Bis(beta-chloroethyl)aminophenylalanine

P-Bis(beta-chloroethyl)aminophenylalanine

P-Bis(β-chloroethyl)aminophenylalanine

p-Di-(2-chloroethyl)amino-L-phenylalanine

P-Di-(2-chloroethyl)amino-L-phenylalanine

Phenylalanine mustard

phenylalanine nitrogen mu stard

Phenylalanine nitrogen mustard

p-L-Sarcolysin

P-L-Sarcolysin

p-L-sarcolysine

p-N,N-bis(2-chloroethyl)amino-L-phenylalanine

P-N,N-Bis(2-chloroethyl)amino-L-phenylalanine

p-N-Bis(2-chloroethyl)amino-L-phenylalanine

P-N-Bis(2-chloroethyl)amino-L-phenylalanine

p-N-di(chloroethyl)aminophenylala nine

p-N-Di(chloroethyl)aminophenylalanine

Prestwick_1006

RCRA waste no. U150

Rcra waste number U150

Sarcolysine

Sarkolysin

SK-15673

SMP2_000174

SMR000058720

SPBio_000287

Spectrum_000397

SPECTRUM1500382

Spectrum2_000074

Spectrum3_000684

Spectrum4_000882

Spectrum5_001601

TL8001065

TRANSGENIC LEP (MELPHALAN) (SEE ALSO MELPHALAN)

TRANSGENIC MODEL EVALUATION (MELPHALAN)

UNII-Q41OR9510P

7

Methylprednisolone

Approved, Vet_approved

Phase 2

83-43-2

6741

Synonyms:

(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione

.DELTA.1-6.alpha.-Methylhydrocortisone

11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

121673-01-6

1-dehydro-6alpha-Methylhydrocortisone

1-Dehydro-6alpha-methylhydrocortisone

1-dehydro-6a-Methylhydrocortisone

1-dehydro-6α-methylhydrocortisone

4-08-00-03498 (Beilstein Handbook Reference)

46436_FLUKA

46436_RIEDEL

570-35-4

6 Methylprednisolone

6.alpha.-Methylprednisolone

6923-42-8

6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione

6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methylprednisolone

6-alpha-Methylprednisolone

6a-Methyl-11b,17a,21-triol-1,4-pregnadiene-3,20-dione

6-Methylprednisolone

6α-methyl-11β,17α,21-triol-1,4-pregnadiene-3,20-dione

83-43-2

AC1L1N7A

Artisone-wyeth

Artisone-Wyeth

Besonia

Bio-0658

BPBio1_000174

BRD-K35240538-001-03-1

BRN 2340300

BSPBio_000158

CHEBI:6888

CHEMBL650

CID6741

CPD000058330

D00407

D008775

DB00959

delta(1)-6alpha-Methylhydrocortisone

Delta(1)-6alpha-Methylhydrocortisone

delta(1)-6a-Methylhydrocortisone

delta(sup 1)-6-alpha-Methylhydrocortisone

Depo-Medrol (acetate)

Dopomedrol

EINECS 201-476-4

Esametone

Firmacort

HMS1568H20

HMS2090B13

HSDB 3127

Lemod

LMST02030178

LS-118498

M0639_SIGMA

M1665

Medesone

Medixon

Medlone 21

Medrate

Medric acid

Medrol

Medrol (TN)

Medrol adt pak

Medrol Adt Pak

Medrol dosepak

Medrol Dosepak

Medrol, Solu-Medrol, Medrone, Methylprednisolone

Medrone

MEPRDL

Mesopren

Metastab

Methyleneprednisolone

Methylprednisolon

methylprednisolone

Methylprednisolone

Methylprednisolone (JP15/USP/INN)

Methylprednisolone [USAN:INN:BAN:JAN]

Methylprednisolone, 6-alpha

Methylprednisolonum

Methylprednisolonum [INN-Latin]

methylprenisolone

Metilbetasone

Metilprednisolona

Metilprednisolona [INN-Spanish]

Metilprednisolone

Metilprednisolone [Dcit]

Metilprednisolone [DCIT]

Metipred

Metrisone

Metrocort

Metysolon

MLS000028541

MLS001148159

MLS002207191

Moderin

MolPort-002-528-554

NCGC00022735-03

NCI60_001657

Nirypan

Noretona

NSC19987

NSC-19987

Predni N Tablinen

Prednol- L

Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)

Prestwick_622

Prestwick0_000279

Prestwick1_000279

Prestwick2_000279

Prestwick3_000279

Promacortine

Reactenol

S1733_Selleck

SAM002589984

Sieropresol

SMR000058330

Solomet

SPBio_002377

Summicort

Suprametil

U 7532

UNII-X4W7ZR7023

Urbason

Urbasone

Wyacort

ZINC03875560

δ(1)-6a-methylhydrocortisone

δ(1)-6α-methylhydrocortisone

8

Prednisolone

Approved, Vet_approved

Phase 2

50-24-8

5755

Synonyms:

(11b)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

(11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione

.DELTA.1-Cortisol

.DELTA.1-Dehydrocortisol

.DELTA.1-Dehydrohydrocortisone

.DELTA.1-Hydrocortisone

.delta.-Cortef

.delta.-Stab

1,2-Dehydrohydrocortisone

1,4-Pregnadiene-11b,17a,21-triol-3,20-dione

1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione

1,4-Pregnadiene-3,20-dione-11b,17a,21-triol

1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol

1,4-Pregnadiene-3,20-dione-11β,17α,21-triol

1-Dehydrocortisol

1-Dehydrohydrocortisone

3,20-dioxo-11b,17a,21-Trihydroxy-1,4-pregnadiene

3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene

3,20-dioxo-11β,17α,21-trihydroxy-1,4-pregnadiene

46656_FLUKA

46656_RIEDEL

50-24-8

58201-11-9

8056-11-9

AC-1773

AC1L1L2E

Ak-Pred

Ak-Tate

Alphadrol

Articulose-50

Bio-0666

BPBio1_000164

BRD-K98039984-001-03-0

BRN 1354103

BSPBio_000148

Bubbli-Pred

C07369

CCRIS 980

CHEBI:8378

CHEMBL131

CID5755

Codelcortone

Co-Hydeltra

CO-Hydeltra

component of Ataraxoid

component of K-Predne-Dome

Cordrol

Cortalone

Cotogesic

Cotolone

CPD000718761

D00472

D011239

DB00860

Decaprednil

Decortin H

Delcortol

Delta F

delta(1)-Cortisol

delta(1)-Dehydrocortisol

Delta(1)-Dehydrocortisol

delta(1)-Dehydrohydrocortisone

Delta(1)-dehydrohydrocortisone

Delta(1)-Dehydrohydrocortisone

delta(1)-Hydrocortisone

Delta(1)-Hydrocortisone

delta(sup 1)-Cortisol

delta(sup 1)-Dehydrocortisol

delta(sup 1)-Dehydrohydrocortisone

delta(sup 1)-Hydrocortisone

Delta-Cortef

Delta-Cortef (TN)

Deltacortenol

Deltacortril

Deltacortril Enteric

delta-dehydrocortisol

delta-dehydrohydrocortisone

Delta-Ef-Cortelan

delta-hydrocortisone

Deltahydrocortisone

Deltasolone

Delta-stab

Delta-Stab

Deltisilone

Depo-Medrol

Derpo Pd

Derpo PD

Dexa-Cortidelt hostacortin H

Dexa-Cortidelt Hostacortin H

Di adreson F

Di Adreson F

Di-adreson F

Di-Adreson F

Di-adreson-F

DiAdresonF

Di-Adreson-F

Dicortol

Donisolone

Dydeltrone

Eazolin D

Econopred

Econopred Plus

EINECS 200-021-7

Erbacort

Erbasona

Estilsona

Fernisolone

Fernisolone P

Fernisolone-P

Flamasone

HMS1568H10

HMS2090J05

Hostacortin H

HSDB 3385

Hydeltra

Hydeltrasol

Hydeltra-Tba

Hydeltrone

Hydrodeltalone

Hydrodeltisone

Hydroretrocortin

Hydroretrocortine

Inflamase Forte

Inflamase Mild

I-Pred

K 1557

Key-Pred

Klismacort

Lentosone

Lite Pred

LMST02030179

LS-7669

Medrol

Medrol Acetate

Metacortandralone

Methylprednisolone acetate

Methylprednisolone Acetate

Meticortelone

Meti-Derm

Metreton

MLS001304083

MLS002154250

MLS002207037

MolPort-002-507-147

M-Predrol

NCGC00179649-01

Neo-Delta-Cortef

Nisolone

Nor-Pred T.B.A.

NSC 9120

NSC9120

NSC9900

Ocu-Pred

Ocu-Pred Forte

Ophtho-Tate

Orapred

P0152_SIGMA

P0637

P6004_SIGMA

Panafcortelone

Paracortol

Paracotol

Pediapred

Poly-Pred

PRDL

Precortalon

Precortancyl

Precortilon

Precortisyl

Pred Forte

Pred Mild

Predair

Predair A

Predair Forte

Predalone 50

Predalone T.B.A.

Predate

Predate Tba

Predate-50

Predcor-25

Predcor-50

Predcor-Tba

PRED-G

Predisolone sodium phosphate

Predisolone Sodium Phosphate

Predne-Dome

Prednelan

Prednicen

Predni-Dome

Predniliderm

Predniretard

Prednis

Prednisolona

Prednisolona [INN-Spanish]

prednisolone

Prednisolone (anhydrous)

Prednisolone (JP15/USP/INN)

Prednisolone [INN:BAN:JAN]

Prednisolone acetate

Prednisolone Acetate

Prednisolone sodium phosphate

Prednisolone Sodium Phosphate

Prednisolone tebutate

Prednisolone Tebutate

Prednisolonum

Prednisolonum [INN-Latin]

Predonin

Predonine

Prelone

Prenolone

Prestwick_404

Prestwick0_000274

Prestwick1_000274

Prestwick2_000274

Prestwick3_000274

Rolisone

S1737_Selleck

SAM002264639

Scherisolon

SMR000718761

Solone

SPBio_002367

Steran

Sterane

Sterolone

Supercortisol

Ulacort

Ultra Pred

Ultracorten H

Ultracortene H

Ultracortene-H

Ultracortene-hydrogen

Ultracortene-Hydrogen

UNII-9PHQ9Y1OLM

ZINC03833821

δ(1)-dehydrocortisol

δ(1)-dehydrohydrocortisone

δ(1)-hydrocortisone

9

Prednisone

Approved, Vet_approved

Phase 2

53-03-2

5865

Synonyms:

(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione

.delta. E

.delta.(sup1)-Cortisone

.delta.1-Cortisone

.delta.1-Dehydrocortisone

.delta.-Cortelan

.delta.-Cortisone

.delta.-Cortone

.delta.-E

.delta.sone

1,2-Dehydrocortisone

1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione

1,4-Pregnadiene-17a,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17α,21-diol-3,11,20-trione

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione

1-Cortisone

1-Dehydrocortisone

53-03-2

68-59-7

81552_FLUKA

AC-11112

AC1L1LB2

AC1Q29EZ

Acis brand OF prednisone

ACon0_000082

ACon1_000297

Adasone

AI3-52939

Ancortone

apo-Prednisone

Apo-prednisone

Apo-Prednisone

Apotex brand OF prednisone

Aventis brand OF prednisone

Betapar

Bicortone

Bio-0649

BPBio1_000323

BRD-K85883481-001-04-2

BSPBio_000293

C07370

C21H26O5

Cartancyl

CCRIS 2646

CHEBI:8382

CHEMBL635

CID5865

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

CPD001227202

Cutason

Dacorten

Dacortin

DB00635

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

delta cortelan

Delta Cortelan

Delta E

Delta E.

delta(sup 1)-Cortisone

delta(sup 1)-Dehydrocortisone

delta-1-Cortisone

delta-1-Dehydrocortisone

Delta-cortelan

Delta-Cortelan

Deltacortene

delta-Cortisone

Deltacortisone

Delta-cortisone

delta-Cortone

Deltacortone

Delta-cortone

Delta-dome

Delta-Dome

Deltasone

Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone

Deltison

Deltisona

Deltisone

Deltra

Diadreson

Di-Adreson

Diba brand OF prednisone

Econosone

EINECS 200-160-3

Encorton

Encortone

Enkortolon

Enkorton

Fawns and mcallan brand OF prednisone

Fernisone

Ferring brand OF prednisone

Fiasone

GALENpharma brand OF prednisone

Halsey drug brand OF prednisone

Hexal brand OF prednisone

HMS1568O15

HMS2090J13

Hoechst brand OF prednisone

Hostacortin

HSDB 3168

ICN brand OF prednisone

Incocortyl

In-Sone

Juvason

Kortancyl

Lichtenstein brand OF prednisone

Liquid pred

Liquid Pred

Lisacort

LMST02030180

Lodotra

LS-1325

MEGxm0_000443

Me-Korti

Merck brand OF prednisone

Merz brand OF prednisone

Metacortandracin

Meticorten

Meticorten (Veterinary)

Metrevet (Veterinary)

Mibe brand OF prednisone

MLS001061265

MLS001304073

MLS001335907

MLS001335908

MLS002154191

MLS002207083

MolPort-001-740-041

NCGC00090766-01

NCGC00090766-02

NCGC00090766-03

NCI60_000008

NCI-C04897

Nisona

Nizon

Novoprednisone

NSC 10023

NSC10023

Nurison

Orasone

Origen Prednisone

P1276

P6254_SIGMA

Panafcort

Panasol

Paracort

Parmenison

Pehacort

Pharmacia brand OF prednisone

PRD

Precort

Predeltin

Predni tablinen

Prednicen-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Predniment

Prednison

Prednison acsis

Prednison galen

Prednison hexal

Prednisona

Prednisona [INN-Spanish]

Prednisone

Prednisone [INN:BAN]

Prednisone Intensol

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Prestwick_405

Prestwick0_000077

Prestwick1_000077

Prestwick2_000077

Prestwick3_000077

Pronison

Pronisone

Rectodelt

Retrocortine

S1622_Selleck

SAM002264641

Schering-plough brand OF prednisone

Seatrace brand OF prednisone

Servisone

SK-Prednisone

SMR000718760

SMR001227202

Solvay brand OF prednisone

Sone

SPBio_002214

Sterapred

Supercortil

Trommsdorff brand OF prednisone

U 6020

Ultracorten

Ultracortene

UNII-VB0R961HZT

Winpred

WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ

Wojtab

Zenadrid

Zenadrid (veterinary)

Zenadrid [veterinary]

ZINC03875357

10

Cyclosporins

Phase 2

11

Methylprednisolone acetate

Phase 2

12

Methylprednisolone Hemisuccinate

Phase 2

13

Prednisolone acetate

Phase 2

14

Prednisolone hemisuccinate

Phase 2

15

Prednisolone phosphate

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases	Completed	NCT01884311	Phase 3
2	Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204)	Completed	NCT01998633	Phase 2

Search NIH Clinical Center for Light Fixation Seizure Syndrome

Sources

Genetic Tests for Light Fixation Seizure Syndrome

Sources

Anatomical Context for Light Fixation Seizure Syndrome

MalaCards organs/tissues related to Light Fixation Seizure Syndrome:

⁴¹

B Cells, Small Intestine, Lymph Node

Sources

Publications for Light Fixation Seizure Syndrome

Articles related to Light Fixation Seizure Syndrome:

(show all 25)

#	Title	Authors	Year
1	Gastrointestinal histoplasmosis ileal stricture successfully treated with through-the-scope balloon dilation in a patient with hyperimmunoglobulin M syndrome. ( 29340926 )	Nehme F....Nassif I.	2018
2	A patient with Charlie M Syndrome: Differential diagnosis of Oromandibular Limb Hypogenesis Syndromes. ( 27132808 )	Jung O....Labow B.	2016
3	Identification of germinal centres in the lymph node of a patient with hyperimmunoglobulin M syndrome associated with congenital rubella. ( 25113848 )	Ameratunga R....Woon S.T.	2014
4	Atypical combined immunodeficiency due to Artemis defect: a case presenting as hyperimmunoglobulin M syndrome and with LGLL. ( 23911390 )	Bajin A.^.Y....Sanal A.9.	2013
5	Hyper-immunoglobulin M syndrome type 3 with normal CD40 cell surface expression. ( 22443339 )	Karaca N.E....Kutukculer N.	2012
6	Novel mutation of the activation-induced cytidine deaminase gene in a Tajik family: special review on hyper-immunoglobulin M syndrome. ( 22992148 )	Mahdaviani S.A....Rezaei N.	2012
7	Nodularity of the small intestine in a child with systemic mastocytosis associated with hyperimmunoglobulin M syndrome. ( 21865968 )	Homan M....AvA8in T.	2011
8	Ataxia-telangiectasia in a patient presenting with hyper-immunoglobulin M syndrome. ( 20945614 )	Aghamohammadi A....Rezaei N.	2010
9	Cellular and molecular characterisation of the hyper immunoglobulin M syndrome associated with congenital rubella infection. ( 18663564 )	Ameratunga R....French J.	2009
10	Molecular genetic analysis of Hungarian patients with the hyper-immunoglobulin M syndrome. ( 17553565 )	Erdos M....MarA^di L.	2008
11	Poorly differentiated gastroenteropancreatic neuroendocrine carcinoma associated with X-linked hyperimmunoglobulin M syndrome. ( 18466034 )	Malhotra R.K....Li W.	2008
12	Neuroendocrine carcinoma associated with X-linked hyper-immunoglobulin M syndrome: report of four cases and review of the literature. ( 18805740 )	Erdos M....MarA^di L.	2008
13	CHARGE association, hyper-immunoglobulin M syndrome, and conjunctival MALT lymphoma. ( 17667624 )	Fuentes-PA!ez G....GarcA-a-Tejeiro M.	2007
14	Hyper-immunoglobulin M syndrome caused by a mutation in the promotor for CD40L. ( 17244160 )	van Hoeyveld E....Bossuyt X.	2007
15	Ataxia-telangiectasia in twins presenting as autosomal recessive hyper-immunoglobulin M syndrome. ( 17591387 )	Etzioni A....Durandy A.	2007
16	X-linked hyper-immunoglobulin M syndrome: molecular genetic study and long-time follow-up of three generations of a Chinese family. ( 16508335 )	Lin S.C....Huang L.H.	2006
17	Hyper immunoglobulin M syndrome due to CD40 deficiency: clinical, molecular, and immunological features. ( 15661021 )	Lougaris V....Plebani A.	2005
18	Recurrent acalculous cholecystitis and sclerosing cholangitis in a patient with X-linked hyper-immunoglobulin M syndrome. ( 16037832 )	Lin S.C....Lee W.I.	2005
19	Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects. ( 15661022 )	Durandy A....Fischer A.	2005
20	Non-X-linked hyperimmunoglobulin M syndrome with chronic interstitial pneumonitis. ( 11206940 )	Quezada A....GonzA!lez S.	2000
21	Previously apparently undescribed autosomal recessive MCA/MR syndrome with light fixation, retinal cone dystrophy, and seizures: the M syndrome. ( 9934988 )	Rauch A....Opitz J.M.	1999
22	Molecular pathology of the X-linked hyper-immunoglobulin M syndrome: detection of wild-type transcripts in a patient with a complex splicing defect of the CD40 ligand. ( 8914765 )	Ameratunga R....Marbrook J.	1996
23	Intrinsic defect in B cells of patients with hyper-immunoglobulin M syndrome. ( 7583916 )	Porat Y.B....Zan-Bar I.	1995
24	[Successful treatment of cyclic neutropenia associated with hyperimmunoglobulin M syndrome using recombinant granulocyte-colony stimulating factor]. ( 7566951 )	Simon G....MarA^di L.	1995
25	Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor. ( 7513136 )	Wang W.C....Conley M.E.	1994

Sources

Genes for Light Fixation Seizure Syndrome

Genes related to Light Fixation Seizure Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CD40LG	CD40 Ligand	Protein Coding	19.12	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	7679801 17244160 8914765
2	CD40	CD40 Molecule	Protein Coding	17.94	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	15661021 8914765

Sources

Variations for Light Fixation Seizure Syndrome

Sources

Expression for Light Fixation Seizure Syndrome

Search GEO for disease gene expression data for Light Fixation Seizure Syndrome.

Sources

Pathways for Light Fixation Seizure Syndrome

Pathways related to Light Fixation Seizure Syndrome according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.18	CD40 CD40LG
2	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.15	CD40 CD40LG
3	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.04	CD40 CD40LG
4	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	11.92	CD40 CD40LG
5	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	11.8	CD40 CD40LG
6	Cell adhesion molecules (CAMs) ³⁷	11.65	CD40 CD40LG
7	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	11.61	CD40 CD40LG
8	NF-kappa B signaling pathway ³⁷	11.43	CD40 CD40LG
9	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²²	11.3	CD40 CD40LG
10	T Cell Co-Signaling Pathway: Ligand-Receptor Interactions ⁶⁵	11.17	CD40 CD40LG
11	B Cell Development Pathways ⁶⁵	11.09	CD40 CD40LG
12	Malaria ³⁷	11.01	CD40 CD40LG
13	Primary immunodeficiency ³⁷	10.82	CD40 CD40LG
14	Inflammatory Response Pathway ¹	10.67	CD40 CD40LG
15	A-beta Pathways: Uptake and Degradation ⁶⁵	10.46	CD40 CD40LG
16	CD40/CD40L signaling ¹	10.1	CD40 CD40LG

Sources

GO Terms for Light Fixation Seizure Syndrome

Cellular components related to Light Fixation Seizure Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.62	CD40 CD40LG

Biological processes related to Light Fixation Seizure Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.48	CD40 CD40LG
2	inflammatory response	GO:0006954	9.46	CD40 CD40LG
3	regulation of immune response	GO:0050776	9.43	CD40 CD40LG
4	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.4	CD40 CD40LG
5	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.37	CD40 CD40LG
6	platelet activation	GO:0030168	9.32	CD40 CD40LG
7	B cell proliferation	GO:0042100	9.26	CD40 CD40LG
8	positive regulation of interleukin-12 production	GO:0032735	9.16	CD40 CD40LG
9	positive regulation of endothelial cell apoptotic process	GO:2000353	8.96	CD40 CD40LG
10	regulation of immunoglobulin secretion	GO:0051023	8.62	CD40 CD40LG

Sources

Sources for Light Fixation Seizure Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁹ FMA

²⁰ GeneAnalytics

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³⁶ IUPHAR

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⁴⁸ NCBI Bookshelf

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⁵² NIH Clinical Center

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⁵⁵ Novoseek

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⁵⁹ Orphanet

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⁶¹ PharmGKB

⁶² PubMed

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⁶⁸ SNOMED-CT

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⁷¹ TGDB

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⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia