Ligneous Conjunctivitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of Ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases. Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.

MalaCards based summary: Ligneous Conjunctivitis, also known as conjunctivitis, ligneous, is related to otitis media and respiratory failure. An important gene associated with Ligneous Conjunctivitis is PLG (Plasminogen), and among its related pathways/superpathways are Complement cascade and Extracellular matrix organization. The drugs Fibrinolytic Agents and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include cervix, trachea and eye.

Wikipedia: ⁷⁵ Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich... more...

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Related Diseases for Ligneous Conjunctivitis

Diseases related to Ligneous Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)

#	Related Disease	Score	Top Affiliating Genes
1	otitis media	30.0	PLG ELANE
2	respiratory failure	29.2	TTR PLG ELANE
3	plasminogen deficiency, type i	11.9
4	conjunctivitis	11.1
5	hydrocephalus	10.6
6	pseudomembranous conjunctivitis	10.5
7	chronic conjunctivitis	10.5
8	congenital hydrocephalus	10.4
9	periodontitis	10.3
10	strabismus	10.2
11	lymphoma, hodgkin, classic	10.2
12	multiple pterygium syndrome, escobar variant	10.2
13	severe cutaneous adverse reaction	10.2
14	ptosis	10.2
15	gingival overgrowth	10.2
16	cellulitis	10.2
17	cataract	10.2
18	conjunctival disease	10.1
19	vasculitis	10.1
20	hypersensitivity vasculitis	10.1
21	dandy-walker syndrome	10.0
22	factor xii deficiency	10.0
23	hydrocephalus due to congenital stenosis of aqueduct of sylvius	10.0
24	familial mediterranean fever	10.0
25	igg4-related disease	10.0
26	gastric ulcer	10.0
27	brucellosis	10.0
28	acute hemorrhagic conjunctivitis	10.0
29	conn's syndrome	10.0
30	entropion	10.0
31	von willebrand's disease	10.0
32	obstructive hydrocephalus	10.0
33	bronchiolitis	10.0
34	gingivitis	10.0
35	pituitary-dependent cushing's disease	10.0
36	conjunctival cancer	10.0
37	kidney disease	10.0
38	peptic ulcer disease	10.0
39	whipple disease	10.0
40	crohn's disease	10.0
41	amyloidosis	10.0
42	keratoconjunctivitis	10.0
43	esotropia	10.0
44	hydrocele	10.0
45	vernal keratoconjunctivitis	10.0
46	posttransplant acute limbic encephalitis	10.0
47	disseminated intravascular coagulation	9.8	PLG ELANE
48	aspergillosis	9.8	PLG ELANE
49	granulomatosis with polyangiitis	9.8	PLG ELANE
50	aortic aneurysm, familial abdominal, 1	9.8	PLG ELANE

Graphical network of the top 20 diseases related to Ligneous Conjunctivitis:

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Symptoms & Phenotypes for Ligneous Conjunctivitis

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Drugs & Therapeutics for Ligneous Conjunctivitis

Drugs for Ligneous Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Fibrinolytic Agents

Phase 3

2

Ophthalmic Solutions

Phase 3

3

Plasminogen

Approved

9001-91-6

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Historically Controlled Phase II/III Study to Evaluate Efficacy and Safety of Kedrion Human Plasminogen Eye Drop Preparation in Patients Diagnosed With Ligneous Conjunctivitis	Completed	NCT01554956	Phase 2, Phase 3
2	The Use of Allogenic Plasma Aliquots as a Source of Plasminogen in the Treatment of Ligneous Conjunctivitis, Clinical Trial of One Case	Enrolling by invitation	NCT04275232	Phase 3
3	Sponsor Initiated Expanded Access Protocol, Intermediate-Size Patient Population	Available	NCT04586062		Plasminogen
4	Management of Recurrent and Progressive Ligneous Conjunctivitis Due to Plasminogen Deficiency. An N of One Clinical Trial of Topical Administration of Allogenic Plasma to Affected Eye	Not yet recruiting	NCT05404932		Aliquoted allogeneic donor plasma in patient's conjunctiva

Search NIH Clinical Center for Ligneous Conjunctivitis

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Genetic Tests for Ligneous Conjunctivitis

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Anatomical Context for Ligneous Conjunctivitis

Organs/tissues related to Ligneous Conjunctivitis:

MalaCards : Cervix, Trachea, Eye, Kidney

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Publications for Ligneous Conjunctivitis

Articles related to Ligneous Conjunctivitis:

(show top 50) (show all 206)

#	Title	Authors	PMID	Year
1	Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. ⁵³ ⁶²	Rodriguez-Ares MT...Cameselle-Teijeiro J	17701212	2007
2	Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis. ⁵³ ⁶²	Mingers AM...Kreth HW	10066157	1998
3	Ligneous Conjunctivitis Secondary to Viral Conjunctivitis. ⁶²	Quintero-Estades JA...Perry HD	36459582	2023
4	Ligneous conjunctivitis associated with type I plasminogen deficiency: A rare case. ⁶²	Dimopoulos D...Koutentakis P	34308677	2022
5	Treatment of Ligneous Conjunctivitis with Plasminogen Eyedrops. ⁶²	Caputo R...Calcinai M	35346720	2022
6	Use of topical allogenic fresh-frozen plasma drops in the treatment of ligneous conjunctivitis. ⁶²	Lily Vidal JA...Bautista DV	34767772	2022
7	Ligneous conjunctivitis mimicking preseptal cellulitis in a 3-month-old infant. ⁶²	Merlevede V...Kreps EO	35769059	2022
8	Recurrent ligneous conjunctivitis after cataract surgery in a 67-year-old male patient: a case report. ⁶²	Maamri A...Seitz B	35247993	2022
9	The first Moroccan case of severe type II congenital plasminogen deficiency with ligneous conjunctivitis. ⁶²	Esselmani H...Lfakir A	35225240	2022
10	A large deletion in the Plasminogen gene is associated with ligneous membranitis in a Maltese dog. ⁶²	Turba ME...Gentilini F	34370320	2021
11	Ligneous conjunctivitis exacerbated by Pseudomonas aeruginosa - Diagnostic and therapeutic approach. ⁶²	Tariq M...Shah HG	34880581	2021
12	[Pharmaceutical supply of human plasminogen replacement therapy for the treatment of ligneous conjunctivitis: Logistics for a university hospital]. ⁶²	Merigot C...Sorli SC	34049718	2021
13	A Novel mRNA Modification Mutation in a Patient With Ligneous Conjunctivitis Coexisting With Heterozygous Familial Mediterranean Fever Mutation. ⁶²	Koseoglu ND...Yildirim N	33734159	2021
14	Novel homozygous mutation of plasminogen in ligneous conjunctivitis: a case report and literature review. ⁶²	Xu L...Ren S	33427557	2021
15	Ligneous conjunctivitis masquerading as a large, recurrent conjunctival tumor. ⁶²	Martel A...Caujolle JP	33288307	2021
16	Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis. ⁶²	Ozbek-Uzman S...Burcu A	33290319	2021
17	Treatment of ligneous conjunctivitis with fresh frozen plasm in twin babies. ⁶²	Yurttaser Ocak S...Bas E	33348042	2021
18	Repurposing of Plasminogen: An Orphan Medicinal Product Suitable for SARS-CoV-2 Inhalable Therapeutics. ⁶²	Piras AM...Crea R	33260813	2020
19	Functional Fibrinolysis Assays Reveal Different Mechanisms underlying Plasminogen Dysfunction in Ligneous Conjunctivitis. ⁶²	Bourrienne MC...Ajzenberg N	32369847	2020
20	An international registry of patients with plasminogen deficiency (HISTORY). ⁶²	Shapiro AD...Peyvandi F	32001536	2020
21	Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature. ⁶²	Sadasivan A...Mathew DG	32274221	2020
22	[Ligneous conjunctivitis: A diagnosis to consider in the case of a lingering pseudomembranous conjunctivitis!] ⁶²	Abdeljelil A...Mahjoub H	31262596	2019
23	Prophylactic protocol for dental care in ligneous gingivitis due to severe plasminogen deficiency: Case report and review of literature. ⁶²	Sartori MT...Fabris F	30994256	2019
24	Diagnosis of a case of ligneous gingivitis in a patient with moderate plasminogen deficiency. ⁶²	Malthiery E...Fauroux MA	30513391	2019
25	Treatment of ligneous conjunctivitis with heterologous serum. ⁶²	Martins TGDS...Kuba MCF	31215592	2019
26	Fresh frozen plasma (Octaplas) and topical heparin in the management of ligneous conjunctivitis. ⁶²	Watts P...Al-Rawas A	30165199	2019
27	Ligneous conjunctivitis in a Dandy-Walker syndrome: A rare case report. ⁶²	Srirampur A...Vemuganti G	30574926	2019
28	Retraction: Treatment of Ligneous Conjunctivitis Using Topical Plasminogen Therapy in An 8-Week-Old Female Infant. ⁶²		30673103	2019
29	Ligneous conjunctivitis due to plasminogen deficit: Diagnostic and therapeutic approach. With literature review. ⁶²	Rouatbi A...Bouguila H	30442487	2018
30	Amniotic membrane transplantation for ligneous conjunctivitis in a doberman. ⁶²	O'Leary L...Plummer C	29482261	2018
31	Clinical, histopathological, and genetic aspects in one case of ligneous conjunctivitis. ⁶²	Raimann R...Gonzalez P	30058940	2018
32	Treatment of Ligneous Conjunctivitis Using Topical Plasminogen Therapy in an 8-Week-Old Female Infant. ⁶²	Shamim MM...Al-Mohtaseb ZN	30180242	2018
33	Ligneous periodontitis in a child with plasminogen deficiency. ⁶²	Ertas U...Gunhan O	29379003	2017
34	Manifestation of tranexamic acid toxicity in chronic kidney disease and kidney transplant patients: A report of four cases and review of literature. ⁶²	Ma TK...Li PK	26970218	2017
35	Topical Plasminogen as Adjunctive Treatment in Recurrent Ligneous Conjunctivitis. ⁶²	Ang MJ...Goldberg RA	27065432	2017
36	Plasminogen deficiency. ⁶²	Celkan T	27629020	2017
37	Letter Regarding "Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature" by Y. Tu et al. ⁶²	Kurtulus-Waschulewski I...Schuster V	26270466	2017
38	[Unilateral upper eyelid membrane in conjunctivitis lignosa]. ⁶²	Bauer M...Nolle B	27638173	2016
39	Molecular pathogenesis of plasminogen Hakodate: the second Japanese family case of severe type I plasminogen deficiency manifested late-onset multi-organic chronic pseudomembranous mucositis. ⁶²	Osaki T...Ichinose A	27193180	2016
40	Co-existing ligneous conjunctivitis and IgG4-related disease. ⁶²	Chiang WY...Kuo MT	27609168	2016
41	[Ligneous conjunctivitis]. ⁶²	Bauer M...Nolle B	26142234	2016
42	Presentation, clinical pathological and post-mortem findings in three related Scottish terriers with ligneous membranitis. ⁶²	Mason SL...Nuttall T	26840763	2016
43	Features and outcome of a glomerulonephropathy associated with ligneous conjunctivitis in a Doberman pinscher dog. ⁶²	Moyer MA...Cianciolo RE	27152037	2016
44	Beyond hemostasis: the challenge of treating plasminogen deficiency. A report of three cases. ⁶²	Pons V...Santamaria A	26036227	2016
45	Novel plasminogen and hyaluronate sodium eye drop formulation for a patient with ligneous conjunctivitis. ⁶²	Conforti FM...Corsetti T	27045067	2016
46	Clinical and histopathological aspects in two cases of ligneous conjunctivitis. ⁶²	Mocanu CL...Jurja S	27516042	2016
47	Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature. ⁶²	Tu Y...Chu DS	25674820	2016
48	Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant. ⁶²	Tunay ZO...Akbay S	26466233	2015
49	Ligneous conjunctivitis in a patient of juvenile colloid milia: A rare association. ⁶²	Bhave SS...Joshi SS	26044480	2015
50	A puzzling case: hypoplasminogenemia, ligneous conjunctivitis and hydrocephalus. ⁶²	Karadag-Oncel E...Meral A	25006691	2015

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Genes for Ligneous Conjunctivitis

Genes related to Ligneous Conjunctivitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PLG	Plasminogen	Protein Coding	26.33	Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	17701212
2	TTR	Transthyretin	Protein Coding	7.33	GeneCards inferred via : Publications (show sections)
3	ELANE	Elastase, Neutrophil Expressed	Protein Coding	5.08	Novoseek inferred ⁵³	10066157

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Variations for Ligneous Conjunctivitis

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Expression for Ligneous Conjunctivitis

Search GEO for disease gene expression data for Ligneous Conjunctivitis.

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Pathways for Ligneous Conjunctivitis

Pathways related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Complement cascade ⁶⁶ Show member pathways Activation of C3 and C5 ⁶⁶ Classical Complement Pathway ⁶⁴ Complement Pathway ⁶⁴ Complement system ⁷⁴ Complement system in neuronal development and plasticity ⁷⁴ Lectin Induced Complement Pathway ⁶⁴ Regulation of Complement cascade ⁶⁶	11.88	PLG ELANE
2	Extracellular matrix organization ⁶⁶ Show member pathways Degradation of the extracellular matrix ⁶⁶	11.44	TTR PLG ELANE
3	Matrix metalloproteinases ⁷⁴ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.26	PLG ELANE
4	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ⁶¹	10.75	PLG ELANE
5	Cell adhesion_Cell-matrix glycoconjugates ²²	10.55	PLG ELANE

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GO Terms for Ligneous Conjunctivitis

Cellular components related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	azurophil granule lumen	GO:0035578	8.92	TTR ELANE

Biological processes related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix disassembly	GO:0022617	8.92	PLG ELANE

Molecular functions related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:0004252	9.46	PLG ELANE
2	serine-type peptidase activity	GO:0008236	9.13	PLG ELANE
3	endopeptidase activity	GO:0004175	8.92	PLG ELANE

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Sources for Ligneous Conjunctivitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LGN005 MIFTS: 30	Ligneous Conjunctivitis Categories: Eye diseases, Rare diseases, Reproductive diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
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