MCID: LGN005
MIFTS: 42

Ligneous Conjunctivitis

Categories: Eye diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Ligneous Conjunctivitis

MalaCards integrated aliases for Ligneous Conjunctivitis:

Name: Ligneous Conjunctivitis 53 73
Conjunctivitis, Ligneous 13 55
Conjunctivitis Lignosa 53

Classifications:



Summaries for Ligneous Conjunctivitis

NIH Rare Diseases : 53 Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases. Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.

MalaCards based summary : Ligneous Conjunctivitis, also known as conjunctivitis, ligneous, is related to plasminogen deficiency, type i and conjunctivitis. An important gene associated with Ligneous Conjunctivitis is PLG (Plasminogen), and among its related pathways/superpathways are Degradation of the extracellular matrix and Selenium Micronutrient Network. The drugs Plasminogen and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include cervix, kidney and trachea, and related phenotypes are macrocephaly and hydrocephalus

Wikipedia : 76 Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich... more...

Related Diseases for Ligneous Conjunctivitis

Diseases related to Ligneous Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 plasminogen deficiency, type i 12.3
2 conjunctivitis 11.1
3 hydrocephalus 10.4
4 congenital plasminogen deficiency 10.3
5 lymphoma 10.2
6 congenital hydrocephalus 10.2
7 strabismus 10.1
8 crohn's disease 10.1
9 autosomal recessive disease 10.1
10 periodontitis 10.1
11 hydrocele 10.1
12 igg4-related disease 10.1
13 chronic ulcer of skin 10.0 ELANE TTR
14 newborn respiratory distress syndrome 10.0 ELANE PLG
15 brown-sequard syndrome 10.0 PLG TTR
16 intracranial embolism 9.9 PLAT PLG
17 inferior myocardial infarction 9.9 PLAT PLG
18 central retinal artery occlusion 9.9 PLAT PLG
19 cardiac rupture 9.9 ELANE PLAT
20 occlusion precerebral artery 9.9 PLAT PLG
21 basilar artery occlusion 9.9 PLAT PLG
22 acute cor pulmonale 9.9 PLAT PLG
23 acute pulmonary heart disease 9.9 PLAT PLG
24 intermediate coronary syndrome 9.9 PLAT PLG
25 pulmonary artery disease 9.9 PLAT PLG
26 carotid artery dissection 9.9 PLAT PLG
27 respiratory failure 9.9 ELANE TTR
28 hepatic veno-occlusive disease 9.9 PLAT PLG
29 vein disease 9.9 PLAT PLG
30 thrombophilia due to activated protein c resistance 9.9 PLAT PLG
31 disseminated intravascular coagulation 9.9 ELANE PLAT
32 gingivitis 9.8 ELANE PLAT
33 arteries, anomalies of 9.8 PLAT PLG
34 coronary artery anomaly 9.8 PLAT PLG
35 acute myocardial infarction 9.8 PLAT PLG
36 vascular disease 9.7 ELANE PLAT PLG
37 nervous system disease 9.7 PLAT PLG TTR
38 central nervous system disease 9.7 PLAT PLG TTR
39 stroke, ischemic 9.7 PLAT PLG

Graphical network of the top 20 diseases related to Ligneous Conjunctivitis:



Diseases related to Ligneous Conjunctivitis

Symptoms & Phenotypes for Ligneous Conjunctivitis

Human phenotypes related to Ligneous Conjunctivitis:

32 (show all 31)
# Description HPO Frequency HPO Source Accession
1 macrocephaly 32 hallmark (90%) HP:0000256
2 hydrocephalus 32 occasional (7.5%) HP:0000238
3 hyperreflexia 32 occasional (7.5%) HP:0001347
4 gingival overgrowth 32 frequent (33%) HP:0000212
5 global developmental delay 32 hallmark (90%) HP:0001263
6 blindness 32 occasional (7.5%) HP:0000618
7 abnormality of the gallbladder 32 occasional (7.5%) HP:0005264
8 recurrent otitis media 32 frequent (33%) HP:0000403
9 gastrointestinal inflammation 32 frequent (33%) HP:0004386
10 cerebellar hypoplasia 32 hallmark (90%) HP:0001321
11 gingivitis 32 frequent (33%) HP:0000230
12 periodontitis 32 frequent (33%) HP:0000704
13 nephrolithiasis 32 occasional (7.5%) HP:0000787
14 recurrent pharyngitis 32 frequent (33%) HP:0100776
15 recurrent pneumonia 32 frequent (33%) HP:0006532
16 papule 32 occasional (7.5%) HP:0200034
17 dandy-walker malformation 32 occasional (7.5%) HP:0001305
18 poor wound healing 32 hallmark (90%) HP:0001058
19 abnormality of fontanelles 32 occasional (7.5%) HP:0011328
20 abnormality of the mediastinum 32 occasional (7.5%) HP:0045026
21 abnormality of the larynx 32 frequent (33%) HP:0001600
22 duodenal ulcer 32 occasional (7.5%) HP:0002588
23 keratoconjunctivitis 32 frequent (33%) HP:0001096
24 nephritis 32 occasional (7.5%) HP:0000123
25 premature loss of teeth 32 frequent (33%) HP:0006480
26 recurrent bronchitis 32 frequent (33%) HP:0002837
27 stomatitis 32 frequent (33%) HP:0010280
28 cervicitis 32 occasional (7.5%) HP:0030160
29 chronic irritative conjunctivitis 32 hallmark (90%) HP:0007717
30 vaginitis 32 occasional (7.5%) HP:0030683
31 epiphora 32 hallmark (90%) HP:0009926

Drugs & Therapeutics for Ligneous Conjunctivitis

Drugs for Ligneous Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Plasminogen Phase 2, Phase 3
2 Pharmaceutical Solutions Phase 2, Phase 3
3 Ophthalmic Solutions Phase 2, Phase 3
4 Fibrinolytic Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis Patients Unknown status NCT01554956 Phase 2, Phase 3

Search NIH Clinical Center for Ligneous Conjunctivitis

Genetic Tests for Ligneous Conjunctivitis

Anatomical Context for Ligneous Conjunctivitis

MalaCards organs/tissues related to Ligneous Conjunctivitis:

41
Cervix, Kidney, Trachea, Eye, Skin, Heart

Publications for Ligneous Conjunctivitis

Articles related to Ligneous Conjunctivitis:

(show top 50) (show all 110)
# Title Authors Year
1
Amniotic membrane transplantation for ligneous conjunctivitis in a doberman. ( 29482261 )
2018
2
Clinical, histopathological, and genetic aspects in one case of ligneous conjunctivitis. ( 30058940 )
2018
3
Fresh frozen plasma (Octaplas) and topical heparin in the management of ligneous conjunctivitis. ( 30165199 )
2018
4
Treatment of Ligneous Conjunctivitis Using Topical Plasminogen Therapy in an 8-Week-Old Female Infant. ( 30180242 )
2018
5
Ligneous conjunctivitis due to plasminogen deficit: Diagnostic and therapeutic approach. With literature review. ( 30442487 )
2018
6
Features and outcome of a glomerulonephropathy associated with ligneous conjunctivitis in a Doberman pinscher dog. ( 27152037 )
2016
7
Novel plasminogen and hyaluronate sodium eye drop formulation for a patient with ligneous conjunctivitis. ( 27045067 )
2016
8
Co-existing ligneous conjunctivitis and IgG4-related disease. ( 27609168 )
2016
9
Topical Plasminogen as Adjunctive Treatment in Recurrent Ligneous Conjunctivitis. ( 27065432 )
2016
10
Clinical and histopathological aspects in two cases of ligneous conjunctivitis. ( 27516042 )
2016
11
A puzzling case: hypoplasminogenemia, ligneous conjunctivitis and hydrocephalus. ( 25006691 )
2015
12
Letter Regarding "Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature" by Y. Tu et al. ( 26270466 )
2015
13
Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant. ( 26466233 )
2015
14
Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature. ( 25674820 )
2015
15
Ligneous conjunctivitis in a patient of juvenile colloid milia: A rare association. ( 26044480 )
2015
16
Tranexamic acid-induced ligneous conjunctivitis with renal failure showed reversible hypoplasminogenaemia. ( 24842363 )
2014
17
Conjunctival instillation of plasminogen eliminates ocular lesion in B6.129P2-Plg(tm1Jld) transgenic mice, a model of ligneous conjunctivitis. ( 23684723 )
2013
18
Is the B6.129P2-Plg transgenic mouse an adequate treatment model for patients with ligneous conjunctivitis? ( 24056190 )
2013
19
Ligneous conjunctivitis in a young patient with homozygous K19E plasminogen gene mutation: a diagnostic and therapeutic challenge. ( 23629776 )
2013
20
Treatment of ligneous conjunctivitis with amniotic membrane transplantation and topical cyclosporine. ( 23202401 )
2012
21
Topical fresh frozen plasma and heparin treatment of ligneous conjunctivitis in a Canadian hospital setting. ( 23036559 )
2012
22
Management of ligneous conjunctivitis in a child with plasminogen deficiency. ( 21625933 )
2011
23
Heparin in the long-term management of ligneous conjunctivitis: a case report and review of literature. ( 21885957 )
2011
24
Induction of bilateral ligneous conjunctivitis with the use of a prosthetic eye. ( 20524141 )
2011
25
Ligneous conjunctivitis in a plasminogen-deficient dog: clinical management and 2-year follow-up. ( 19604341 )
2009
26
Ligneous conjunctivitis with plasminogen deficiency. ( 19006564 )
2009
27
The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: successful treatment with direct thrombin inhibitor and fresh plasma. ( 19373890 )
2009
28
Successful treatment of ligneous conjunctivitis with topical cyclosporine and heparin. ( 19840736 )
2009
29
Ligneous conjunctivitis with oral mucous membrane involvement and decreased plasminogen level. ( 19689523 )
2009
30
Fresh frozen plasma treatment of ligneous conjunctivitis: use of heparin and allogeneic serum. ( 19092425 )
2009
31
Ligneous periodontitis is an analog lesion of ligneous conjunctivitis and described 150 years later. ( 19782618 )
2009
32
Ligneous conjunctivitis secondary to a congenital plasminogen deficiency in a dog. ( 18312178 )
2008
33
Systemic and topical fresh-frozen plasma treatment in a newborn with ligneous conjunctivitis. ( 18434858 )
2008
34
Ligneous conjunctivitis in a patient with Crohn's disease. ( 19668406 )
2008
35
Long-term efficacy of surgical removal of pseudomembranes in a child with ligneous conjunctivitis treated with plasminogen eyedrops. ( 19132249 )
2008
36
Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. ( 17701212 )
2007
37
Difficulties in mutation screening of the plasminogen (PLG) gene in patients with ligneous conjunctivitis and severe hypoplasminogenemia. ( 17846386 )
2007
38
Ligneous conjunctivitis: a case report with multiorgan involvement. ( 17448029 )
2007
39
Molecular characterization of an Italian patient with plasminogen deficiency and ligneous conjunctivitis. ( 17179833 )
2007
40
Ligneous conjunctivitis in a Mexican patient with a mutation in the plasminogen (PLG) gene. ( 17030725 )
2006
41
Juvenile colloid milium and ligneous conjunctivitis are caused by severe hypoplasminogenemia--no evidence for causal relationship to non-Hodgkin's lymphoma. ( 17062083 )
2006
42
Difficulties in the mutation analysis of plasminogen gene: a study in two patients with ligneous conjunctivitis. ( 16444438 )
2006
43
Congenital hydrocephalus as a rare association with ligneous conjunctivitis and type I plasminogen deficiency. ( 15822024 )
2005
44
Non-Hodgkin's lymphoma and auricular hypoplasia: associated with juvenile colloid milium or ligneous conjunctivitis? ( 15857463 )
2005
45
Amniotic membrane transplantation in a case of ligneous conjunctivitis. ( 15059718 )
2004
46
Prevention of ligneous conjunctivitis by topical and subconjunctival fresh frozen plasma. ( 15289146 )
2004
47
Therapeutic approaches in the treatment of ligneous conjunctivitis, the most common clinical manifestation of a systemic disease, caused by severe type I plasminogen deficiency. ( 15488842 )
2004
48
Ligneous conjunctivitis, hydrocephalus, hydrocele, and pulmonary involvement in a child with homozygous type I plasminogen deficiency. ( 12719968 )
2003
49
Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis. ( 12876630 )
2003
50
Otolaryngological manifestations of ligneous conjunctivitis. ( 12623158 )
2003

Variations for Ligneous Conjunctivitis

Expression for Ligneous Conjunctivitis

Search GEO for disease gene expression data for Ligneous Conjunctivitis.

Pathways for Ligneous Conjunctivitis

Pathways related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.15 ELANE PLG TTR
2
Show member pathways
11.86 PLAT PLG
3 11.78 ELANE PLAT
4
Show member pathways
11.7 PLAT PLG
5 11.62 PLAT PLG
6
Show member pathways
11.56 PLAT PLG
7
Show member pathways
11.43 ELANE PLG
8 11.19 PLAT PLG
9 11.06 PLAT PLG
10 10.85 ELANE PLG
11 10.52 PLAT PLG
12 10.48 ELANE PLAT PLG
13 10.07 PLAT PLG

GO Terms for Ligneous Conjunctivitis

Cellular components related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.62 ELANE PLAT PLG TTR
2 extracellular exosome GO:0070062 9.46 ELANE PLAT PLG TTR
3 cell surface GO:0009986 9.43 ELANE PLAT PLG
4 secretory granule GO:0030141 9.4 ELANE PLAT
5 azurophil granule lumen GO:0035578 9.37 ELANE TTR
6 extracellular space GO:0005615 9.26 ELANE PLAT PLG TTR
7 collagen-containing extracellular matrix GO:0062023 8.8 ELANE PLAT PLG

Biological processes related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.33 ELANE PLAT PLG
2 cellular protein metabolic process GO:0044267 9.32 PLG TTR
3 blood coagulation GO:0007596 9.26 PLAT PLG
4 extracellular matrix disassembly GO:0022617 8.96 ELANE PLG
5 fibrinolysis GO:0042730 8.62 PLAT PLG

Molecular functions related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.33 ELANE PLAT PLG
2 endopeptidase activity GO:0004175 9.26 ELANE PLG
3 serine-type endopeptidase activity GO:0004252 9.13 ELANE PLAT PLG
4 serine-type peptidase activity GO:0008236 8.8 ELANE PLAT PLG

Sources for Ligneous Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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