MCID: LGN005
MIFTS: 30

Ligneous Conjunctivitis

Categories: Eye diseases, Rare diseases, Reproductive diseases, Respiratory diseases
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Aliases & Classifications for Ligneous Conjunctivitis

MalaCards integrated aliases for Ligneous Conjunctivitis:

Name: Ligneous Conjunctivitis 19 71 75 33
Conjunctivitis, Ligneous 53
Conjunctivitis Lignosa 19

Classifications:



External Ids:

ICD11 33 1464324556
UMLS 71 C1274789

Summaries for Ligneous Conjunctivitis

GARD: 19 Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of Ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases. Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.

MalaCards based summary: Ligneous Conjunctivitis, also known as conjunctivitis, ligneous, is related to otitis media and respiratory failure. An important gene associated with Ligneous Conjunctivitis is PLG (Plasminogen), and among its related pathways/superpathways are Complement cascade and Extracellular matrix organization. The drugs Fibrinolytic Agents and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include cervix, trachea and eye.

Wikipedia: 75 Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich... more...

Related Diseases for Ligneous Conjunctivitis

Diseases related to Ligneous Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 otitis media 30.0 PLG ELANE
2 respiratory failure 29.2 TTR PLG ELANE
3 plasminogen deficiency, type i 11.9
4 conjunctivitis 11.1
5 hydrocephalus 10.6
6 pseudomembranous conjunctivitis 10.5
7 chronic conjunctivitis 10.5
8 congenital hydrocephalus 10.4
9 periodontitis 10.3
10 strabismus 10.2
11 lymphoma, hodgkin, classic 10.2
12 multiple pterygium syndrome, escobar variant 10.2
13 severe cutaneous adverse reaction 10.2
14 ptosis 10.2
15 gingival overgrowth 10.2
16 cellulitis 10.2
17 cataract 10.2
18 conjunctival disease 10.1
19 vasculitis 10.1
20 hypersensitivity vasculitis 10.1
21 dandy-walker syndrome 10.0
22 factor xii deficiency 10.0
23 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.0
24 familial mediterranean fever 10.0
25 igg4-related disease 10.0
26 gastric ulcer 10.0
27 brucellosis 10.0
28 acute hemorrhagic conjunctivitis 10.0
29 conn's syndrome 10.0
30 entropion 10.0
31 von willebrand's disease 10.0
32 obstructive hydrocephalus 10.0
33 bronchiolitis 10.0
34 gingivitis 10.0
35 pituitary-dependent cushing's disease 10.0
36 conjunctival cancer 10.0
37 kidney disease 10.0
38 peptic ulcer disease 10.0
39 whipple disease 10.0
40 crohn's disease 10.0
41 amyloidosis 10.0
42 keratoconjunctivitis 10.0
43 esotropia 10.0
44 hydrocele 10.0
45 vernal keratoconjunctivitis 10.0
46 posttransplant acute limbic encephalitis 10.0
47 disseminated intravascular coagulation 9.8 PLG ELANE
48 aspergillosis 9.8 PLG ELANE
49 granulomatosis with polyangiitis 9.8 PLG ELANE
50 aortic aneurysm, familial abdominal, 1 9.8 PLG ELANE

Graphical network of the top 20 diseases related to Ligneous Conjunctivitis:



Diseases related to Ligneous Conjunctivitis

Symptoms & Phenotypes for Ligneous Conjunctivitis

Drugs & Therapeutics for Ligneous Conjunctivitis

Drugs for Ligneous Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrinolytic Agents Phase 3
2 Ophthalmic Solutions Phase 3
3
Plasminogen Approved 9001-91-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Historically Controlled Phase II/III Study to Evaluate Efficacy and Safety of Kedrion Human Plasminogen Eye Drop Preparation in Patients Diagnosed With Ligneous Conjunctivitis Completed NCT01554956 Phase 2, Phase 3
2 The Use of Allogenic Plasma Aliquots as a Source of Plasminogen in the Treatment of Ligneous Conjunctivitis, Clinical Trial of One Case Enrolling by invitation NCT04275232 Phase 3
3 Sponsor Initiated Expanded Access Protocol, Intermediate-Size Patient Population Available NCT04586062 Plasminogen
4 Management of Recurrent and Progressive Ligneous Conjunctivitis Due to Plasminogen Deficiency. An N of One Clinical Trial of Topical Administration of Allogenic Plasma to Affected Eye Not yet recruiting NCT05404932 Aliquoted allogeneic donor plasma in patient's conjunctiva

Search NIH Clinical Center for Ligneous Conjunctivitis

Genetic Tests for Ligneous Conjunctivitis

Anatomical Context for Ligneous Conjunctivitis

Organs/tissues related to Ligneous Conjunctivitis:

MalaCards : Cervix, Trachea, Eye, Kidney

Publications for Ligneous Conjunctivitis

Articles related to Ligneous Conjunctivitis:

(show top 50) (show all 206)
# Title Authors PMID Year
1
Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. 53 62
17701212 2007
2
Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis. 53 62
10066157 1998
3
Ligneous Conjunctivitis Secondary to Viral Conjunctivitis. 62
36459582 2023
4
Ligneous conjunctivitis associated with type I plasminogen deficiency: A rare case. 62
34308677 2022
5
Treatment of Ligneous Conjunctivitis with Plasminogen Eyedrops. 62
35346720 2022
6
Use of topical allogenic fresh-frozen plasma drops in the treatment of ligneous conjunctivitis. 62
34767772 2022
7
Ligneous conjunctivitis mimicking preseptal cellulitis in a 3-month-old infant. 62
35769059 2022
8
Recurrent ligneous conjunctivitis after cataract surgery in a 67-year-old male patient: a case report. 62
35247993 2022
9
The first Moroccan case of severe type II congenital plasminogen deficiency with ligneous conjunctivitis. 62
35225240 2022
10
A large deletion in the Plasminogen gene is associated with ligneous membranitis in a Maltese dog. 62
34370320 2021
11
Ligneous conjunctivitis exacerbated by Pseudomonas aeruginosa - Diagnostic and therapeutic approach. 62
34880581 2021
12
[Pharmaceutical supply of human plasminogen replacement therapy for the treatment of ligneous conjunctivitis: Logistics for a university hospital]. 62
34049718 2021
13
A Novel mRNA Modification Mutation in a Patient With Ligneous Conjunctivitis Coexisting With Heterozygous Familial Mediterranean Fever Mutation. 62
33734159 2021
14
Novel homozygous mutation of plasminogen in ligneous conjunctivitis: a case report and literature review. 62
33427557 2021
15
Ligneous conjunctivitis masquerading as a large, recurrent conjunctival tumor. 62
33288307 2021
16
Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis. 62
33290319 2021
17
Treatment of ligneous conjunctivitis with fresh frozen plasm in twin babies. 62
33348042 2021
18
Repurposing of Plasminogen: An Orphan Medicinal Product Suitable for SARS-CoV-2 Inhalable Therapeutics. 62
33260813 2020
19
Functional Fibrinolysis Assays Reveal Different Mechanisms underlying Plasminogen Dysfunction in Ligneous Conjunctivitis. 62
32369847 2020
20
An international registry of patients with plasminogen deficiency (HISTORY). 62
32001536 2020
21
Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature. 62
32274221 2020
22
[Ligneous conjunctivitis: A diagnosis to consider in the case of a lingering pseudomembranous conjunctivitis!] 62
31262596 2019
23
Prophylactic protocol for dental care in ligneous gingivitis due to severe plasminogen deficiency: Case report and review of literature. 62
30994256 2019
24
Diagnosis of a case of ligneous gingivitis in a patient with moderate plasminogen deficiency. 62
30513391 2019
25
Treatment of ligneous conjunctivitis with heterologous serum. 62
31215592 2019
26
Fresh frozen plasma (Octaplas) and topical heparin in the management of ligneous conjunctivitis. 62
30165199 2019
27
Ligneous conjunctivitis in a Dandy-Walker syndrome: A rare case report. 62
30574926 2019
28
Retraction: Treatment of Ligneous Conjunctivitis Using Topical Plasminogen Therapy in An 8-Week-Old Female Infant. 62
30673103 2019
29
Ligneous conjunctivitis due to plasminogen deficit: Diagnostic and therapeutic approach. With literature review. 62
30442487 2018
30
Amniotic membrane transplantation for ligneous conjunctivitis in a doberman. 62
29482261 2018
31
Clinical, histopathological, and genetic aspects in one case of ligneous conjunctivitis. 62
30058940 2018
32
Treatment of Ligneous Conjunctivitis Using Topical Plasminogen Therapy in an 8-Week-Old Female Infant. 62
30180242 2018
33
Ligneous periodontitis in a child with plasminogen deficiency. 62
29379003 2017
34
Manifestation of tranexamic acid toxicity in chronic kidney disease and kidney transplant patients: A report of four cases and review of literature. 62
26970218 2017
35
Topical Plasminogen as Adjunctive Treatment in Recurrent Ligneous Conjunctivitis. 62
27065432 2017
36
Plasminogen deficiency. 62
27629020 2017
37
Letter Regarding "Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature" by Y. Tu et al. 62
26270466 2017
38
[Unilateral upper eyelid membrane in conjunctivitis lignosa]. 62
27638173 2016
39
Molecular pathogenesis of plasminogen Hakodate: the second Japanese family case of severe type I plasminogen deficiency manifested late-onset multi-organic chronic pseudomembranous mucositis. 62
27193180 2016
40
Co-existing ligneous conjunctivitis and IgG4-related disease. 62
27609168 2016
41
[Ligneous conjunctivitis]. 62
26142234 2016
42
Presentation, clinical pathological and post-mortem findings in three related Scottish terriers with ligneous membranitis. 62
26840763 2016
43
Features and outcome of a glomerulonephropathy associated with ligneous conjunctivitis in a Doberman pinscher dog. 62
27152037 2016
44
Beyond hemostasis: the challenge of treating plasminogen deficiency. A report of three cases. 62
26036227 2016
45
Novel plasminogen and hyaluronate sodium eye drop formulation for a patient with ligneous conjunctivitis. 62
27045067 2016
46
Clinical and histopathological aspects in two cases of ligneous conjunctivitis. 62
27516042 2016
47
Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature. 62
25674820 2016
48
Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant. 62
26466233 2015
49
Ligneous conjunctivitis in a patient of juvenile colloid milia: A rare association. 62
26044480 2015
50
A puzzling case: hypoplasminogenemia, ligneous conjunctivitis and hydrocephalus. 62
25006691 2015

Variations for Ligneous Conjunctivitis

Expression for Ligneous Conjunctivitis

Search GEO for disease gene expression data for Ligneous Conjunctivitis.

Pathways for Ligneous Conjunctivitis

Pathways related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 PLG ELANE
2
Show member pathways
11.44 TTR PLG ELANE
3
Show member pathways
11.26 PLG ELANE
4 10.75 PLG ELANE
5 10.55 PLG ELANE

GO Terms for Ligneous Conjunctivitis

Cellular components related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.92 TTR ELANE

Biological processes related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 8.92 PLG ELANE

Molecular functions related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.46 PLG ELANE
2 serine-type peptidase activity GO:0008236 9.13 PLG ELANE
3 endopeptidase activity GO:0004175 8.92 PLG ELANE

Sources for Ligneous Conjunctivitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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