Aliases & Classifications for Ligneous Conjunctivitis

MalaCards integrated aliases for Ligneous Conjunctivitis:

Name: Ligneous Conjunctivitis 53 73
Conjunctivitis, Ligneous 13 55
Conjunctivitis Lignosa 53

Classifications:



Summaries for Ligneous Conjunctivitis

NIH Rare Diseases : 53 Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases. Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.

MalaCards based summary : Ligneous Conjunctivitis, also known as conjunctivitis, ligneous, is related to plasminogen deficiency, type i and conjunctivitis. An important gene associated with Ligneous Conjunctivitis is PLG (Plasminogen), and among its related pathways/superpathways are Degradation of the extracellular matrix and Folate Metabolism. The drugs Ephedrine and Pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include trachea, cervix and kidney, and related phenotypes are nephritis and gingival overgrowth

Wikipedia : 76 Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich... more...

Related Diseases for Ligneous Conjunctivitis

Graphical network of the top 20 diseases related to Ligneous Conjunctivitis:



Diseases related to Ligneous Conjunctivitis

Symptoms & Phenotypes for Ligneous Conjunctivitis

Human phenotypes related to Ligneous Conjunctivitis:

32 (show all 31)
# Description HPO Frequency HPO Source Accession
1 nephritis 32 occasional (7.5%) HP:0000123
2 gingival overgrowth 32 frequent (33%) HP:0000212
3 gingivitis 32 frequent (33%) HP:0000230
4 hydrocephalus 32 occasional (7.5%) HP:0000238
5 macrocephaly 32 hallmark (90%) HP:0000256
6 recurrent otitis media 32 frequent (33%) HP:0000403
7 blindness 32 occasional (7.5%) HP:0000618
8 periodontitis 32 frequent (33%) HP:0000704
9 nephrolithiasis 32 occasional (7.5%) HP:0000787
10 poor wound healing 32 hallmark (90%) HP:0001058
11 keratoconjunctivitis 32 frequent (33%) HP:0001096
12 global developmental delay 32 hallmark (90%) HP:0001263
13 dandy-walker malformation 32 occasional (7.5%) HP:0001305
14 cerebellar hypoplasia 32 hallmark (90%) HP:0001321
15 hyperreflexia 32 occasional (7.5%) HP:0001347
16 abnormality of the larynx 32 frequent (33%) HP:0001600
17 duodenal ulcer 32 occasional (7.5%) HP:0002588
18 recurrent bronchitis 32 frequent (33%) HP:0002837
19 gastrointestinal inflammation 32 frequent (33%) HP:0004386
20 abnormality of the gallbladder 32 occasional (7.5%) HP:0005264
21 premature loss of teeth 32 frequent (33%) HP:0006480
22 recurrent pneumonia 32 frequent (33%) HP:0006532
23 chronic irritative conjunctivitis 32 hallmark (90%) HP:0007717
24 epiphora 32 hallmark (90%) HP:0009926
25 stomatitis 32 frequent (33%) HP:0010280
26 abnormality of fontanelles 32 occasional (7.5%) HP:0011328
27 cervicitis 32 occasional (7.5%) HP:0030160
28 vaginitis 32 occasional (7.5%) HP:0030683
29 abnormality of the mediastinum 32 occasional (7.5%) HP:0045026
30 recurrent pharyngitis 32 frequent (33%) HP:0100776
31 papule 32 occasional (7.5%) HP:0200034

Drugs & Therapeutics for Ligneous Conjunctivitis

Drugs for Ligneous Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 2, Phase 3 299-42-3 9294
2
Pseudoephedrine Approved Phase 2, Phase 3 90-82-4 7028
3 Fibrinolytic Agents Phase 2, Phase 3
4 Respiratory System Agents Phase 2, Phase 3
5 Nasal Decongestants Phase 2, Phase 3
6 Tetrahydrozoline Phase 2, Phase 3
7 Ophthalmic Solutions Phase 2, Phase 3
8 Vasoconstrictor Agents Phase 2, Phase 3
9 Peripheral Nervous System Agents Phase 2, Phase 3
10 Pharmaceutical Solutions Phase 2, Phase 3
11 Plasminogen Phase 2, Phase 3
12 Autonomic Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis Patients Unknown status NCT01554956 Phase 2, Phase 3

Search NIH Clinical Center for Ligneous Conjunctivitis

Genetic Tests for Ligneous Conjunctivitis

Anatomical Context for Ligneous Conjunctivitis

MalaCards organs/tissues related to Ligneous Conjunctivitis:

41
Trachea, Cervix, Kidney, Eye

Publications for Ligneous Conjunctivitis

Articles related to Ligneous Conjunctivitis:

(show all 40)
# Title Authors Year
1
Amniotic membrane transplantation for ligneous conjunctivitis in a doberman. ( 29482261 )
2018
2
Features and outcome of a glomerulonephropathy associated with ligneous conjunctivitis in a Doberman pinscher dog. ( 27152037 )
2016
3
Novel plasminogen and hyaluronate sodium eye drop formulation for a patient with ligneous conjunctivitis. ( 27045067 )
2016
4
Co-existing ligneous conjunctivitis and IgG4-related disease. ( 27609168 )
2016
5
Topical Plasminogen as Adjunctive Treatment in Recurrent Ligneous Conjunctivitis. ( 27065432 )
2016
6
Clinical and histopathological aspects in two cases of ligneous conjunctivitis. ( 27516042 )
2016
7
A puzzling case: hypoplasminogenemia, ligneous conjunctivitis and hydrocephalus. ( 25006691 )
2015
8
Letter Regarding "Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature" by Y. Tu et al. ( 26270466 )
2015
9
Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant. ( 26466233 )
2015
10
Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature. ( 25674820 )
2015
11
Ligneous conjunctivitis in a patient of juvenile colloid milia: A rare association. ( 26044480 )
2015
12
Tranexamic acid-induced ligneous conjunctivitis with renal failure showed reversible hypoplasminogenaemia. ( 24842363 )
2014
13
Conjunctival instillation of plasminogen eliminates ocular lesion in B6.129P2-Plg(tm1Jld) transgenic mice, a model of ligneous conjunctivitis. ( 23684723 )
2013
14
Is the B6.129P2-Plg transgenic mouse an adequate treatment model for patients with ligneous conjunctivitis? ( 24056190 )
2013
15
Ligneous conjunctivitis in a young patient with homozygous K19E plasminogen gene mutation: a diagnostic and therapeutic challenge. ( 23629776 )
2013
16
Treatment of ligneous conjunctivitis with amniotic membrane transplantation and topical cyclosporine. ( 23202401 )
2012
17
Topical fresh frozen plasma and heparin treatment of ligneous conjunctivitis in a Canadian hospital setting. ( 23036559 )
2012
18
Management of ligneous conjunctivitis in a child with plasminogen deficiency. ( 21625933 )
2011
19
Heparin in the long-term management of ligneous conjunctivitis: a case report and review of literature. ( 21885957 )
2011
20
Induction of bilateral ligneous conjunctivitis with the use of a prosthetic eye. ( 20524141 )
2011
21
Ligneous conjunctivitis in a plasminogen-deficient dog: clinical management and 2-year follow-up. ( 19604341 )
2009
22
Ligneous conjunctivitis with plasminogen deficiency. ( 19006564 )
2009
23
The first two Japanese cases of severe type I congenital plasminogen deficiency with ligneous conjunctivitis: successful treatment with direct thrombin inhibitor and fresh plasma. ( 19373890 )
2009
24
Successful treatment of ligneous conjunctivitis with topical cyclosporine and heparin. ( 19840736 )
2009
25
Ligneous conjunctivitis with oral mucous membrane involvement and decreased plasminogen level. ( 19689523 )
2009
26
Fresh frozen plasma treatment of ligneous conjunctivitis: use of heparin and allogeneic serum. ( 19092425 )
2009
27
Ligneous periodontitis is an analog lesion of ligneous conjunctivitis and described 150 years later. ( 19782618 )
2009
28
Ligneous conjunctivitis secondary to a congenital plasminogen deficiency in a dog. ( 18312178 )
2008
29
Systemic and topical fresh-frozen plasma treatment in a newborn with ligneous conjunctivitis. ( 18434858 )
2008
30
Ligneous conjunctivitis in a patient with Crohn's disease. ( 19668406 )
2008
31
Long-term efficacy of surgical removal of pseudomembranes in a child with ligneous conjunctivitis treated with plasminogen eyedrops. ( 19132249 )
2008
32
Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. ( 17701212 )
2007
33
Difficulties in mutation screening of the plasminogen (PLG) gene in patients with ligneous conjunctivitis and severe hypoplasminogenemia. ( 17846386 )
2007
34
Ligneous conjunctivitis, hydrocephalus, hydrocele, and pulmonary involvement in a child with homozygous type I plasminogen deficiency. ( 12719968 )
2003
35
Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis. ( 12876630 )
2003
36
Ligneous conjunctivitis: biochemical evidence for hypofibrinolysis. ( 10704063 )
2000
37
Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis. ( 10233898 )
1999
38
Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency. ( 9834305 )
1998
39
Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis. ( 10066157 )
1998
40
Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis. ( 9242524 )
1997

Variations for Ligneous Conjunctivitis

Expression for Ligneous Conjunctivitis

Search GEO for disease gene expression data for Ligneous Conjunctivitis.

Pathways for Ligneous Conjunctivitis

GO Terms for Ligneous Conjunctivitis

Cellular components related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.67 ELANE PLAT PLG TTR
2 extracellular region GO:0005576 9.56 ELANE PLAT PLG TTR
3 secretory granule GO:0030141 9.32 ELANE PLAT
4 azurophil granule lumen GO:0035578 9.16 ELANE TTR
5 cell surface GO:0009986 9.13 ELANE PLAT PLG
6 extracellular space GO:0005615 8.92 ELANE PLAT PLG TTR

Biological processes related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.33 ELANE PLAT PLG
2 cellular protein metabolic process GO:0044267 9.32 PLG TTR
3 blood coagulation GO:0007596 9.26 PLAT PLG
4 extracellular matrix disassembly GO:0022617 8.96 ELANE PLG
5 fibrinolysis GO:0042730 8.62 PLAT PLG

Molecular functions related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.33 ELANE PLAT PLG
2 endopeptidase activity GO:0004175 9.26 ELANE PLG
3 serine-type endopeptidase activity GO:0004252 9.13 ELANE PLAT PLG
4 serine-type peptidase activity GO:0008236 8.8 ELANE PLAT PLG

Sources for Ligneous Conjunctivitis

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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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