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MCID: LGN005
MIFTS: 30

Ligneous Conjunctivitis

Categories: Eye diseases, Rare diseases, Reproductive diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ligneous Conjunctivitis

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MalaCards integrated aliases for Ligneous Conjunctivitis:

Name: Ligneous Conjunctivitis 20 70
Conjunctivitis, Ligneous 54
Conjunctivitis Lignosa 20

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Respiratory diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 70 C1274789
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Summaries for Ligneous Conjunctivitis

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GARD : 20 Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss. A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases. Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.

MalaCards based summary : Ligneous Conjunctivitis, also known as conjunctivitis, ligneous, is related to plasminogen deficiency, type i and gingivitis. An important gene associated with Ligneous Conjunctivitis is PLG (Plasminogen), and among its related pathways/superpathways are Degradation of the extracellular matrix and Transcriptional misregulation in cancer. The drugs Fibrinolytic Agents and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include cervix, trachea and eye.

Wikipedia : 73 Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich... more...

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Related Diseases for Ligneous Conjunctivitis

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Diseases related to Ligneous Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 plasminogen deficiency, type i 32.6 PLG PLAT
2 gingivitis 29.9 PLAT ELANE
3 congenital plasminogen deficiency 11.4
4 conjunctivitis 11.1
5 hydrocephalus 10.5
6 pseudomembranous conjunctivitis 10.4
7 chronic conjunctivitis 10.4
8 congenital hydrocephalus 10.4
9 periodontitis 10.3
10 otitis media 10.2
11 strabismus 10.2
12 yemenite deaf-blind hypopigmentation syndrome 10.2
13 autosomal recessive disease 10.2
14 ptosis 10.2
15 mechanical strabismus 10.2
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
17 conjunctival disease 10.1
18 vasculitis 10.1
19 dandy-walker syndrome 10.0
20 factor xii deficiency 10.0
21 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.0
22 familial mediterranean fever 10.0
23 branchiootic syndrome 1 10.0
24 proteinuria, chronic benign 10.0
25 igg4-related disease 10.0
26 monocular esotropia 10.0
27 gastric ulcer 10.0
28 brucellosis 10.0
29 respiratory failure 10.0
30 entropion 10.0
31 von willebrand's disease 10.0
32 obstructive hydrocephalus 10.0
33 bronchiolitis 10.0
34 cellulitis 10.0
35 kidney disease 10.0
36 peptic ulcer disease 10.0
37 cataract 10.0
38 whipple disease 10.0
39 crohn's disease 10.0
40 amyloidosis 10.0
41 keratoconjunctivitis 10.0
42 esotropia 10.0
43 hydrocele 10.0
44 vernal keratoconjunctivitis 10.0
45 posttransplant acute limbic encephalitis 10.0
46 angioedema 10.0 PLG PLAT
47 basal ganglia cerebrovascular disease 10.0 PLG PLAT
48 cerebral falx meningioma 10.0 PLG PLAT
49 basilar artery insufficiency 10.0 PLG PLAT
50 basilar artery occlusion 10.0 PLG PLAT

Graphical network of the top 20 diseases related to Ligneous Conjunctivitis:



Diseases related to Ligneous Conjunctivitis
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Symptoms & Phenotypes for Ligneous Conjunctivitis

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Drugs & Therapeutics for Ligneous Conjunctivitis

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Drugs for Ligneous Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrinolytic Agents Phase 3
2 Ophthalmic Solutions Phase 3
3 Plasminogen Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Historically Controlled Phase II/III Study to Evaluate Efficacy and Safety of Kedrion Human Plasminogen Eye Drop Preparation in Patients Diagnosed With Ligneous Conjunctivitis Completed NCT01554956 Phase 2, Phase 3
2 The Use of Allogenic Plasma Aliquots as a Source of Plasminogen in the Treatment of Ligneous Conjunctivitis, Clinical Trial of One Case Enrolling by invitation NCT04275232 Phase 3
3 Sponsor Initiated Expanded Access Protocol, Intermediate-Size Patient Population Available NCT04586062 Plasminogen

Search NIH Clinical Center for Ligneous Conjunctivitis

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Genetic Tests for Ligneous Conjunctivitis

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Anatomical Context for Ligneous Conjunctivitis

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MalaCards organs/tissues related to Ligneous Conjunctivitis:

40
Cervix, Trachea, Eye, Kidney
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Publications for Ligneous Conjunctivitis

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Articles related to Ligneous Conjunctivitis:

(show top 50) (show all 184)
# Title Authors PMID Year
1
Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. 61 54
17701212 2007
2
Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis. 61 54
10066157 1998
3
Novel homozygous mutation of plasminogen in ligneous conjunctivitis: a case report and literature review. 61
33427557 2021
4
Ligneous conjunctivitis masquerading as a large, recurrent conjunctival tumor. 61
33288307 2021
5
Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis. 61
33290319 2021
6
A Novel mRNA Modification Mutation in a Patient With Ligneous Conjunctivitis Coexisting With Heterozygous Familial Mediterranean Fever Mutation. 61
33734159 2021
7
Treatment of ligneous conjunctivitis with fresh frozen plasm in twin babies. 61
33348042 2021
8
Repurposing of Plasminogen: An Orphan Medicinal Product Suitable for SARS-CoV-2 Inhalable Therapeutics. 61
33260813 2020
9
Functional Fibrinolysis Assays Reveal Different Mechanisms underlying Plasminogen Dysfunction in Ligneous Conjunctivitis. 61
32369847 2020
10
An international registry of patients with plasminogen deficiency (HISTORY). 61
32001536 2020
11
Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature. 61
32274221 2020
12
[Ligneous conjunctivitis: A diagnosis to consider in the case of a lingering pseudomembranous conjunctivitis!] 61
31262596 2019
13
Prophylactic protocol for dental care in ligneous gingivitis due to severe plasminogen deficiency: Case report and review of literature. 61
30994256 2019
14
Diagnosis of a case of ligneous gingivitis in a patient with moderate plasminogen deficiency. 61
30513391 2019
15
Treatment of ligneous conjunctivitis with heterologous serum. 61
31215592 2019
16
Fresh frozen plasma (Octaplas) and topical heparin in the management of ligneous conjunctivitis. 61
30165199 2019
17
Retraction: Treatment of Ligneous Conjunctivitis Using Topical Plasminogen Therapy in An 8-Week-Old Female Infant. 61
30673103 2019
18
Ligneous conjunctivitis in a Dandy-Walker syndrome: A rare case report. 61
30574926 2019
19
Ligneous conjunctivitis due to plasminogen deficit: Diagnostic and therapeutic approach. With literature review. 61
30442487 2018
20
Amniotic membrane transplantation for ligneous conjunctivitis in a doberman. 61
29482261 2018
21
Clinical, histopathological, and genetic aspects in one case of ligneous conjunctivitis. 61
30058940 2018
22
Treatment of Ligneous Conjunctivitis Using Topical Plasminogen Therapy in an 8-Week-Old Female Infant. 61
30180242 2018
23
Ligneous periodontitis in a child with plasminogen deficiency. 61
29379003 2017
24
Manifestation of tranexamic acid toxicity in chronic kidney disease and kidney transplant patients: A report of four cases and review of literature. 61
26970218 2017
25
Topical Plasminogen as Adjunctive Treatment in Recurrent Ligneous Conjunctivitis. 61
27065432 2017
26
Letter Regarding "Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature" by Y. Tu et al. 61
26270466 2017
27
Plasminogen deficiency. 61
27629020 2017
28
Molecular pathogenesis of plasminogen Hakodate: the second Japanese family case of severe type I plasminogen deficiency manifested late-onset multi-organic chronic pseudomembranous mucositis. 61
27193180 2016
29
Co-existing ligneous conjunctivitis and IgG4-related disease. 61
27609168 2016
30
Presentation, clinical pathological and post-mortem findings in three related Scottish terriers with ligneous membranitis. 61
26840763 2016
31
Features and outcome of a glomerulonephropathy associated with ligneous conjunctivitis in a Doberman pinscher dog. 61
27152037 2016
32
[Ligneous conjunctivitis]. 61
26142234 2016
33
Novel plasminogen and hyaluronate sodium eye drop formulation for a patient with ligneous conjunctivitis. 61
27045067 2016
34
Beyond hemostasis: the challenge of treating plasminogen deficiency. A report of three cases. 61
26036227 2016
35
Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature. 61
25674820 2016
36
Clinical and histopathological aspects in two cases of ligneous conjunctivitis. 61
27516042 2016
37
Successful treatment of ligneous conjunctivitis with topical fresh frozen plasma in an infant. 61
26466233 2015
38
Ligneous conjunctivitis in a patient of juvenile colloid milia: A rare association. 61
26044480 2015
39
A puzzling case: hypoplasminogenemia, ligneous conjunctivitis and hydrocephalus. 61
25006691 2015
40
Root dentin anomaly and a PLG mutation. 61
25281489 2014
41
Tranexamic acid-induced ligneous conjunctivitis with renal failure showed reversible hypoplasminogenaemia. 61
24842363 2014
42
Is the B6.129P2-Plg transgenic mouse an adequate treatment model for patients with ligneous conjunctivitis? 61
24056190 2013
43
Conjunctival instillation of plasminogen eliminates ocular lesion in B6.129P2-Plg(tm1Jld) transgenic mice, a model of ligneous conjunctivitis. 61
23684723 2013
44
Ligneous conjunctivitis in a young patient with homozygous K19E plasminogen gene mutation: a diagnostic and therapeutic challenge. 61
23629776 2013
45
[Ligneous conjunctivitis]. 61
22975272 2012
46
Treatment of ligneous conjunctivitis with amniotic membrane transplantation and topical cyclosporine. 61
23202401 2012
47
Topical fresh frozen plasma and heparin treatment of ligneous conjunctivitis in a Canadian hospital setting. 61
23036559 2012
48
Destructive membranous periodontal disease (ligneous gingivitis): a literature review. 61
21859319 2012
49
Management of ligneous conjunctivitis in a child with plasminogen deficiency. 61
21625933 2011
50
Heparin in the long-term management of ligneous conjunctivitis: a case report and review of literature. 61
21885957 2011
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Variations for Ligneous Conjunctivitis

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Expression for Ligneous Conjunctivitis

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Search GEO for disease gene expression data for Ligneous Conjunctivitis.
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Pathways for Ligneous Conjunctivitis

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Pathways related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 65
Show member pathways
 12.15 TTR PLG ELANE
2
Transcriptional misregulation in cancer 36
11.78 PLAT ELANE
3
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.68 PLG PLAT
4
Complement and coagulation cascades 36 1
11.62 PLG PLAT
5
Matrix Metalloproteinases 1
Show member pathways
 11.43 PLG ELANE
6
Cell adhesion_ECM remodeling 23
11.19 PLG PLAT
7
Cell adhesion_Plasmin signaling 23
11.06 PLG PLAT
8
Cell adhesion_Cell-matrix glycoconjugates 23
10.85 PLG ELANE
9
A-beta Pathways: Plaque Formation and APP Metabolism 64
10.52 PLG PLAT
10
amb2 Integrin signaling 1
10.48 PLG PLAT ELANE
11
Dissolution of Fibrin Clot 65
10.07 PLG PLAT
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GO Terms for Ligneous Conjunctivitis

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Cellular components related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.67 TTR PLG PLAT ELANE
2 extracellular exosome GO:0070062 9.46 TTR PLG PLAT ELANE
3 cell surface GO:0009986 9.43 PLG PLAT ELANE
4 secretory granule GO:0030141 9.4 PLAT ELANE
5 azurophil granule lumen GO:0035578 9.32 TTR ELANE
6 extracellular space GO:0005615 9.26 TTR PLG PLAT ELANE
7 collagen-containing extracellular matrix GO:0062023 8.8 PLG PLAT ELANE

Biological processes related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.33 PLG PLAT ELANE
2 blood coagulation GO:0007596 9.26 PLG PLAT
3 extracellular matrix disassembly GO:0022617 8.96 PLG ELANE
4 fibrinolysis GO:0042730 8.62 PLG PLAT

Molecular functions related to Ligneous Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.33 PLG PLAT ELANE
2 endopeptidase activity GO:0004175 9.26 PLG ELANE
3 serine-type endopeptidase activity GO:0004252 9.13 PLG PLAT ELANE
4 serine-type peptidase activity GO:0008236 8.8 PLG PLAT ELANE
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Sources for Ligneous Conjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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