MCID: LMB014
MIFTS: 21

Limb-Body Wall Complex

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Limb-Body Wall Complex

MalaCards integrated aliases for Limb-Body Wall Complex:

Name: Limb-Body Wall Complex 54
Limb Body Wall Complex 54 60
Short Umbilical Cord Syndrome 54
Umbilical Cord, Short 54
Short Umbilical Cord 30
Aplasia of the Cord 54
Body Stalk Anomaly 54
Lbwc Syndrome 60
Cyllosomas 54

Characteristics:

Orphanet epidemiological data:

60
limb body wall complex
Inheritance: Not applicable; Prevalence: 1-9/100000 (Australia); Age of onset: Infancy,Neonatal; Age of death: early childhood;

Classifications:



External Ids:

ICD10 via Orphanet 35 Q87.8
Orphanet 60 ORPHA2369

Summaries for Limb-Body Wall Complex

NIH Rare Diseases : 54 Limb-body wall complex (LBWC) is a condition characterized by multiple, severe congenital abnormalities in a fetus. It typically results in openings in the anterior body wall (chest and belly) and defects of the limbs (arms and legs). Other features of LBWC may include facial clefts; a short or missing umbilical cord; scoliosis; neural tube defects; and abnormalities of the urogenital organs (i.e. kidney, bladder, and/or genitals). The exact cause of LBWC is unclear. Unfortunately, there is no cure for LBWC and it is considered to be incompatible with life (fatal). The majority of affected pregnancies end in fetal demise.

MalaCards based summary : Limb-Body Wall Complex, also known as limb body wall complex, is related to constricting bands, congenital and sirenomelia. Affiliated tissues include kidney and placenta.

Wikipedia : 77 Limb body wall complex (LBWC) is a rare fetal malformation of unknown... more...

Related Diseases for Limb-Body Wall Complex

Diseases related to Limb-Body Wall Complex via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 constricting bands, congenital 10.2
2 sirenomelia 10.1
3 coloboma of macula 10.0
4 anus, imperforate 10.0
5 oeis complex 10.0
6 thoracoabdominal syndrome 10.0
7 omphalocele 10.0
8 placenta accreta 10.0
9 cocaine abuse 10.0
10 amniotic band syndrome 10.0
11 pentalogy of cantrell 10.0
12 ectopia cordis 10.0
13 abdominal wall defect 9.8

Graphical network of the top 20 diseases related to Limb-Body Wall Complex:



Diseases related to Limb-Body Wall Complex

Symptoms & Phenotypes for Limb-Body Wall Complex

Drugs & Therapeutics for Limb-Body Wall Complex

Search Clinical Trials , NIH Clinical Center for Limb-Body Wall Complex

Genetic Tests for Limb-Body Wall Complex

Genetic tests related to Limb-Body Wall Complex:

# Genetic test Affiliating Genes
1 Short Umbilical Cord 30

Anatomical Context for Limb-Body Wall Complex

MalaCards organs/tissues related to Limb-Body Wall Complex:

42
Kidney, Placenta

Publications for Limb-Body Wall Complex

Articles related to Limb-Body Wall Complex:

(show top 50) (show all 58)
# Title Authors Year
1
Detection of hypomethylation of H19 in a pregnancy with limb-body wall complex. ( 30342671 )
2018
2
Limb body wall complex: Its delineation and relationship with amniotic bands using clustering methods. ( 30589520 )
2018
3
Limb Body Wall Complex Associated with Placenta Accreta: A Mere Coincidence or a Sign of an Etiopathogenic Link? ( 28257587 )
2017
4
Thoracoschisis associated with Limb Body Wall Complex. ( 28540190 )
2017
5
Prenatal sonographic diagnosis of limb-body wall complex: case series of a rare congenital anomaly. ( 27257465 )
2016
6
Possible Genetic Origin of Limb-Body Wall Complex. ( 26111189 )
2015
7
Limb body wall complex, amniotic band sequence, or new syndrome caused by mutation in IQ Motif containing K (IQCK)? ( 26436108 )
2015
8
Significance of fibrotic bands in utero--Amniotic band sequence with limb body wall complex: A rare case of fetal autopsy. ( 26549084 )
2015
9
Prenatal MRI evaluation of limb-body wall complex. ( 24928524 )
2014
10
Early diagnosis of limb body wall complex: a case report. ( 24992795 )
2014
11
Omphalocele, exstrophy of cloaca, imperforate anus and spinal defect (OEIS Complex) with overlapping features of body stalk anomaly (limb body wall complex). ( 25400352 )
2014
12
Limb body wall complex with sacrococcygeal mass and agenesis of external genitalia. ( 23970900 )
2013
13
Limb body wall complex: a rare anomaly. ( 24014975 )
2013
14
Cases of limb-body wall complex: Early amnion rupture, vascular disruption, or abnormal splitting of the embryo? ( 27625829 )
2012
15
Prenatal ultrasound demonstration of limb-body wall complex with megacystis. ( 21791324 )
2011
16
First-trimester two-dimensional and three-dimensional ultrasound demonstration of craniofacial defects, abdominal wall defects and upper limb deficiency associated with limb-body wall complex. ( 22212340 )
2011
17
Amniotic band syndrome and/or limb body wall complex: split or lump. ( 23776348 )
2010
18
Pentalogy of Cantrell vs. limb body wall complex: differential diagnosis of a severe malformation in early pregnancy. ( 19998210 )
2009
19
Limb-body wall complex in one fetus of a dizygotic twin pregnancy conceived by egg donation, in vitro fertilization and embryo transfer: prenatal diagnosis and literature review. ( 20045776 )
2009
20
Limb body wall complex. ( 18603699 )
2008
21
Limb body wall complex in a still born fetus: a case report. ( 18699998 )
2008
22
Limb-body wall complex with craniofacial defects after ovarian stimulation. ( 19126523 )
2008
23
On the spectrum of limb-body wall complex, exstrophy of the cloaca, and urorectal septum malformation sequence. ( 17431896 )
2007
24
Second-trimester diagnosis of limb-body wall complex with literature review of pathogenesis. ( 17515306 )
2007
25
Prenatal ultrasonographical features of limb body wall complex: a review of etiopathogenesis and a new classification. ( 17886024 )
2007
26
Limb body wall complex and amniotic band sequence in sibs. ( 17937432 )
2007
27
Three-dimensional multiplanar ultrasound in a limb-body wall complex fetus: clinical evidence for counseling. ( 16581607 )
2006
28
Prenatal imaging of limb-body wall complex by magnetic resonance imaging. ( 15968622 )
2005
29
Limb Body Wall Complex. ( 27407587 )
2004
30
Prenatal diagnosis of limb-body wall complex in early pregnancy using three-dimensional ultrasound. ( 12813769 )
2003
31
Prenatal sonographic diagnosis of limb-body wall complex with craniofacial defects. ( 12858316 )
2003
32
A case of limb-body wall complex diagnosed in utero. ( 12865119 )
2003
33
Limb body wall complex. ( 14530552 )
2003
34
Prenatal diagnosis of acrania associated with facial defects, amniotic bands and limb-body wall complex. ( 12100428 )
2002
35
Limb-body wall complex: a case series. ( 12420845 )
2002
36
Prenatal diagnosis of limb-body wall complex with craniofacial defects, amniotic bands, adhesions and upper limb deficiency. ( 11360287 )
2001
37
Limb-body wall complex, report of 2 cases with their quintessence in prenatal diagnosis. ( 11460977 )
2001
38
Limb-body wall complex: a compound anomaly pattern in body-wall defects. ( 11527200 )
2001
39
Prenatal diagnosis of anophthalmos with limb-body wall complex. ( 11015711 )
2000
40
Prenatal diagnosis of limb-body wall complex using two- and three-dimensional ultrasound. ( 11113921 )
2000
41
Limb-body wall complex: 4 new cases illustrating the importance of examining placenta and umbilical cord. ( 11186176 )
2000
42
Prenatal diagnosis of limb-body wall complex. ( 9749415 )
1998
43
Limb body wall complex: craniofacial defects as a distinctive factor. ( 9125324 )
1996
44
Limb body wall complex: analysis of eight fetuses. ( 9125325 )
1996
45
Epidemiology of limb-body wall complex in Japan. ( 8092190 )
1994
46
Significance of fetography in prenatal diagnosis of limb-body wall complex (LBWC). ( 7907044 )
1993
47
Limb body wall complex: a critical review and a nosological proposal. ( 8279488 )
1993
48
Limb-body wall complex with anophthalmos and choroidal coloboma. ( 8372034 )
1993
49
Limb-body wall complex associated with cocaine abuse: further evidence of cocaine's teratogenicity. ( 1386662 )
1992
50
New case of limb body-wall complex associated with sirenomelia sequence. ( 1481813 )
1992

Variations for Limb-Body Wall Complex

Expression for Limb-Body Wall Complex

Search GEO for disease gene expression data for Limb-Body Wall Complex.

Pathways for Limb-Body Wall Complex

GO Terms for Limb-Body Wall Complex

Sources for Limb-Body Wall Complex

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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