Limb Ischemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LMB062 MIFTS: 51	Limb Ischemia Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs Download Expand all tables

Sources

Aliases & Classifications for Limb Ischemia

MalaCards integrated aliases for Limb Ischemia:

Name: Limb Ischemia ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050852

UMLS ⁷³ C2945695

Sources

Summaries for Limb Ischemia

MalaCards based summary : Limb Ischemia is related to critical limb ischemia and peripheral artery disease. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Aspirin and Menthol have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related phenotypes are cardiovascular system and cellular

Sources

Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)

#	Related Disease	Score	Top Affiliating Genes
1	critical limb ischemia	33.3	HGF HIF1A IL6 TNF VEGFA VWF
2	peripheral artery disease	30.1	ACE IL6 NOS3 VEGFA
3	endocarditis	30.0	IL6 TNF TNNI3
4	infective endocarditis	29.8	IL6 TNF TNNI3
5	intermittent claudication	29.7	ACE IL6 VEGFA VWF
6	ischemia	29.4	ACE CXCL12 EDN1 HIF1A NOS3 VEGFA
7	peripheral vascular disease	29.4	ACE IL6 VEGFA VWF
8	connective tissue disease	28.7	ACE EDN1 IL6 TNF
9	diabetes mellitus	28.5	ACE EDN1 IL6 NOS3 TNF VEGFA
10	coronary artery anomaly	27.6	ACE EDN1 IL6 NOS3 TNNI3 VWF
11	vascular disease	27.3	ACE EDN1 FGF2 IL6 NOS3 TNF
12	dilated cardiomyopathy	27.2	ACE EDN1 IL6 NOS3 TNF TNNI3
13	arteries, anomalies of	26.6	ACE EDN1 IL6 NOS3 PGF TNF
14	scorpion envenomation	10.8	IL6 TNF
15	intravascular papillary endothelial hyperplasia	10.8	HIF1A VEGFA
16	hemifacial spasm	10.8	NOS3 VEGFA
17	wrinkles	10.8	HGF VEGFA
18	leukomalacia	10.8	IL6 TNF
19	angioimmunoblastic lymphadenopathy with dysproteinemia	10.7	IL6 TNF
20	eales disease	10.6	IL6 TNF VEGFA
21	rosacea	10.6	IL6 TNF VEGFA
22	infiltrating angiolipoma	10.6	VEGFA VWF
23	cerebral artery occlusion	10.6	HIF1A NOS3 TNF
24	laryngitis	10.6	FGF2 IL6 TNF
25	female reproductive system disease	10.6	IL6 TNF VEGFA
26	streptococcal toxic-shock syndrome	10.6	IL6 TNF
27	null-cell leukemia	10.5	IL6 TNF
28	chronic mountain sickness	10.5	EDN1 NOS3 VEGFA
29	angiodysplasia	10.5	FGF2 VEGFA VWF
30	lymphangiosarcoma	10.5	TNF VEGFA VWF
31	osteosclerotic myeloma	10.5	IL6 TNF VWF
32	angiokeratoma circumscriptum	10.5	KDR VEGFA
33	meconium aspiration syndrome	10.5	EDN1 IL6 TNF
34	gastrointestinal system cancer	10.5	IL6 TNF VEGFA
35	diffuse meningeal melanocytosis	10.5	EDN1 HGF
36	varicose veins	10.5	HIF1A VEGFA VWF
37	mesangial proliferative glomerulonephritis	10.5	EDN1 FGF2 IL6
38	apnea, obstructive sleep	10.4	EDN1 IL6 TNF
39	pyogenic granuloma	10.4	ANGPT2 TEK VEGFA
40	complex regional pain syndrome	10.4	EDN1 IL6 TNF
41	takayasu arteritis	10.4	IL6 TNF VWF
42	plasmodium vivax malaria	10.4	ANGPT2 IL6 TNF
43	arteriovenous malformations of the brain	10.4	IL6 KDR VEGFA
44	pericardial effusion	10.4	FGF2 HIF1A IL6 VEGFA
45	atherosclerosis susceptibility	10.4	IL6 NOS3 TNF
46	angiomatous meningioma	10.4	FGF2 KDR VEGFA
47	endotheliitis	10.4
48	capillary hemangioma	10.4	KDR TEK VEGFA
49	dry eye syndrome	10.3	FGF2 HGF IL6 TNF
50	parasitic protozoa infectious disease	10.3	IL6 KDR TNF

Graphical network of the top 20 diseases related to Limb Ischemia:

Sources

Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

⁴⁶ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.46	TNNI3 TEK VEGFA TNF VWF ANGPT2
2	cellular	MP:0005384	10.29	VEGFA TNF VWF FGF2 ANGPT2 HGF
3	homeostasis/metabolism	MP:0005376	10.29	PGF TEK VEGFA TNF VWF FGF2
4	mortality/aging	MP:0010768	10.28	TNNI3 TEK VEGFA TNF VWF FGF2
5	hematopoietic system	MP:0005397	10.27	TEK VEGFA TNF VWF FGF2 HGF
6	growth/size/body region	MP:0005378	10.25	TNF PGF TEK VEGFA ACE HGF
7	immune system	MP:0005387	10.2	PGF VEGFA TNF VWF ANGPT2 CXCL12
8	digestive/alimentary	MP:0005381	10.14	VEGFA TNF VWF ANGPT2 EDN1 HIF1A
9	embryo	MP:0005380	10.13	TNF PGF TEK VEGFA HGF EDN1
10	muscle	MP:0005369	10.11	TNNI3 TEK VEGFA TNF CXCL12 HIF1A
11	liver/biliary system	MP:0005370	10.09	VEGFA TNF HGF CXCL12 HIF1A ACE
12	nervous system	MP:0003631	10	TEK VEGFA TNF VWF FGF2 CXCL12
13	neoplasm	MP:0002006	9.87	PGF VEGFA TNF FGF2 ACE HIF1A
14	respiratory system	MP:0005388	9.81	TNNI3 VEGFA TNF ANGPT2 PGF HIF1A
15	skeleton	MP:0005390	9.56	TNF VEGFA FGF2 EDN1 HIF1A KDR
16	vision/eye	MP:0005391	9.32	TEK VEGFA TNF FGF2 ANGPT2 HIF1A

Sources

Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 233)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Aspirin

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Early Phase 1

50-78-2

2244

Menthol

Approved

Phase 4,Phase 2,Phase 3,Not Applicable

2216-51-5

16666

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Chlorhexidine

Approved, Vet_approved

Phase 4

55-56-1

9552079 2713

Clindamycin

Approved, Vet_approved

Phase 4

18323-44-9

29029

Iodine

Approved, Investigational

Phase 4,Not Applicable

7553-56-2

807

Metronidazole

Approved

Phase 4

443-48-1

4173

Povidone

Approved

Phase 4

9003-39-8

Povidone-iodine

Approved

Phase 4

25655-41-8

Teicoplanin

Approved, Investigational

Phase 4

61036-62-2

Paclitaxel

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Not Applicable

33069-62-4

36314

Heparin

Approved, Investigational

Phase 4,Phase 1,Phase 2,Not Applicable

9005-49-6

772 46507594

Cilostazol

Approved, Investigational

Phase 4,Phase 3,Phase 2

73963-72-1

2754

Clopidogrel

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

120202-66-6, 113665-84-2

60606

Ticlopidine

Approved

Phase 4,Phase 3,Phase 2

55142-85-3

5472

Lenograstim

Approved, Investigational

Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1

135968-09-1

Alprostadil

Approved, Investigational

Phase 4,Phase 2

745-65-3

149351 5280723

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 2

50-02-2

5743

Dalteparin

Approved

Phase 4,Phase 2

9005-49-6

Defibrotide

Approved, Investigational

Phase 4

83712-60-1

Iloprost

Approved, Investigational

Phase 4

78919-13-8

6443959

Pentoxifylline

Approved, Investigational

Phase 4

6493-05-6

4740

Ramipril

Approved

Phase 4

87333-19-5

5362129

Benzocaine

Approved, Investigational

Phase 4,Phase 3,Phase 2

1994-09-7, 94-09-7

2337

Zinc

Approved, Investigational

Phase 4,Phase 3

7440-66-6

23994

Febuxostat

Approved

Phase 4

144060-53-7

134018

Pregabalin

Approved, Illicit, Investigational

Phase 4

148553-50-8

5486971

Insulin Glargine

Approved

Phase 4

160337-95-1

Ephedrine

Approved

Phase 4

299-42-3

9294

Norepinephrine

Approved

Phase 4

51-41-2

439260

Oxymetazoline

Approved, Investigational

Phase 4

1491-59-4

4636

Phenylephrine

Approved

Phase 4

59-42-7

6041

Pseudoephedrine

Approved

Phase 4

90-82-4

7028

Glucosamine

Approved, Investigational, Nutraceutical

Phase 4

3416-24-8

439213

tannic acid

Approved, Nutraceutical

Phase 4,Phase 3,Phase 2

Uric Acid

Experimental, Investigational

Phase 4

69-93-2

1175

Amoxicillin-Potassium Clavulanate Combination

Phase 4

Anti-Bacterial Agents

Phase 4,Phase 2,Not Applicable

Antibiotics, Antitubercular

Phase 4,Phase 2,Not Applicable

Anti-Infective Agents

Phase 4,Phase 2,Not Applicable

Anti-Infective Agents, Local

Phase 4,Not Applicable

Antiparasitic Agents

Phase 4

Antiprotozoal Agents

Phase 4

Antitubercular Agents

Phase 4

beta-Lactamase Inhibitors

Phase 4

Blood Substitutes

Phase 4,Phase 2

cadexomer iodine

Phase 4,Not Applicable

Chlorhexidine gluconate

Phase 4

Clavulanic Acid

Phase 4

Clindamycin palmitate

Phase 4

Interventional clinical trials:

(show top 50) (show all 462)

#	Name	Status	NCT ID	Phase	Drugs
1	Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II)	Unknown status	NCT01173094	Phase 4
2	Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I)	Unknown status	NCT01171703	Phase 4
3	Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix	Unknown status	NCT02279784	Phase 4
4	The Amputation Surgical Site Infection Trial (ASSIT)	Unknown status	NCT02018094	Phase 4	Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
5	Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery	Unknown status	NCT01147419	Phase 4
6	Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND)	Completed	NCT00906022	Phase 4
7	Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia	Completed	NCT02369809	Phase 4	Neovasculgen®
8	Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation	Completed	NCT01558505	Phase 4
9	Cryoplasty CLIMB-registry	Completed	NCT00459888	Phase 4
10	Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE)	Completed	NCT00883246	Phase 4
11	Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV	Completed	NCT00596752	Phase 4	Alprostadil
12	DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions	Completed	NCT00637741	Phase 4
13	Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp)	Completed	NCT00300690	Phase 4
14	Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions	Completed	NCT00764777	Phase 4
15	NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions	Completed	NCT01783600	Phase 4
16	Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans	Completed	NCT02117206	Phase 4	L-arginine (L-arginine Veyron);Nacl
17	Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease	Completed	NCT01983449	Phase 4	Dexamethasone Sodium Phosphate Injection, USP
18	Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery	Completed	NCT01427621	Phase 4
19	AngioSeal Versus Radial Approach in Acute Coronary Syndrome	Completed	NCT01653587	Phase 4
20	Instrumental Sealing of Arterial Puncture Site Closure Device Versus Manual Compression Trial	Completed	NCT01389375	Phase 4
21	Peripheral Vascular Disease and Nerve Stimulation	Completed	NCT01942941	Phase 4
22	Optimization of Treatment in Patients With Severe Peripheral Ischemia (Fontaine Stage IIb)	Completed	NCT01718288	Phase 4	iloprost;Standard Treatment (aspirin.....),
23	Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants	Completed	NCT01037530	Phase 4	Ramipril
24	The Study to Compare SMART Nitinol Stent and Balloon Angioplasty	Completed	NCT00309595	Phase 4
25	The Study to Compare the Cordis SMART™ Stent System With the Bard® Luminexx™ Stent	Completed	NCT00235131	Phase 4
26	DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions	Completed	NCT01412463	Phase 4
27	Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia	Recruiting	NCT02563535	Phase 4
28	Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging	Recruiting	NCT02807779	Phase 4	Dexamethasone infusion
29	Lowering-hyperuricemia Treatment on Cardiovascular Outcomes in Peritoneal Dialysis Patients	Recruiting	NCT03200210	Phase 4	Febuxostat;Placebo
30	Vascular Closure Device Versus Transradial Approach in Primary Percutaneous Coronary Intervention	Recruiting	NCT02831166	Phase 4
31	Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery	Recruiting	NCT02085551	Phase 4
32	Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study)	Not yet recruiting	NCT02829151	Phase 4	Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
33	Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE)	Not yet recruiting	NCT03549923	Phase 4	Esmolol;Standard care
34	Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia	Terminated	NCT00403780	Phase 4	pregabalin;placebo
35	Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia	Terminated	NCT00504088	Phase 4
36	Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty	Terminated	NCT01150617	Phase 4	Insulin glargine plus insulin analogues
37	Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients	Terminated	NCT02203630	Phase 4	Phenylephrine;Norepinephrine
38	AGIR Study: Angio-Seal in Interventional Radiology	Terminated	NCT01911403	Phase 4
39	Use Art-assist and Neupogen to Treat Chronic Limb Ischemia	Withdrawn	NCT02408991	Phase 4	Neupogen
40	Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells	Unknown status	NCT01833585	Phase 3
41	Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia	Unknown status	NCT00539266	Phase 2, Phase 3
42	VADOplex Critical Limb Ischemia Study	Unknown status	NCT02034539	Phase 2, Phase 3
43	Distal Venous Arterialisation of Ischemic Limb	Unknown status	NCT01211925	Phase 2, Phase 3	Aspirin
44	Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia	Unknown status	NCT00434616	Phase 2, Phase 3
45	Transfer of Cardioprotection During RIPC	Unknown status	NCT01956708	Phase 2, Phase 3
46	Remote Ischemic Preconditioning in Coronary Artery Bypass Grafting With Cold Crystalloid Cardioplegic Arrest	Unknown status	NCT01406678	Phase 2, Phase 3	isoflurane+sufentanil anesthesia
47	Pain and Music Therapy in Patients Suffering Arteritis	Unknown status	NCT01323504	Phase 3
48	Transfusion Requirements in Critically Ill Oncologic Patient	Unknown status	NCT01648946	Phase 3
49	NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study	Unknown status	NCT00358085	Phase 3
50	Claudication: Exercise Versus Endoluminal Revascularization (CLEVER)	Unknown status	NCT00132743	Phase 3	Cilostazol

Search NIH Clinical Center for Limb Ischemia

Sources

Genetic Tests for Limb Ischemia

Sources

Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

⁴¹

Bone, Bone Marrow, Kidney, Heart, Endothelial, Brain, Liver

Sources

Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 847)

#	Title	Authors	Year
1	Human primary CD34<sup>+</sup> cells transplantation for critical limb ischemia. ( 29893031 )	Lian W....Li M.	2018
2	Acute Limb Ischemia Secondary to Native Artery Occlusion: Results of a Contemporary Case Series. ( 29404750 )	SeguA- N....ClarA! A.	2018
3	Efficacy Outcomes of Endovascular Versus Surgical Revascularization in Critical Limb Ischemia: Results From a Prospective Cohort Study. ( 29355026 )	Schindewolf M....Baumgartner I.	2018
4	Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. ( 29373539 )	Simon F....Duran M.	2018
5	Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion. ( 29960153 )	Hsieh K.F....Yeh S.L.	2018
6	Lower limb ischemia due to popliteal artery compression by Baker cyst. ( 29942891 )	Fujiyoshi K....Ako J.	2018
7	Lower extremity bypass and endovascular intervention for critical limb ischemia fail to meet Society for Vascular Surgery's objective performance goals for limb-related outcomes in a contemporary national cohort. ( 29937289 )	Robinson W.P....Upchurch G.R.	2018
8	Rationale and design of the SAIL trial for intramuscular injection of allogeneic mesenchymal stromal cells in no-option critical limb ischemia. ( 29242062 )	Wijnand J.G.J....Verhaar M.C.	2018
9	Natural language processing of clinical notes for identification of critical limb ischemia. ( 29425639 )	Afzal N....Arruda-Olson A.M.	2018
10	Spinal Cord Stimulation Improves the Microvascular Perfusion Insufficiency Caused by Critical Limb Ischemia. ( 29377343 )	Liu J.T....Chang C.S.	2018
11	Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia. ( 29796803 )	Lykov A.P....Poveshchenko A.F.	2018
12	Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan. ( 29386474 )	Kondo K....Matoba S.	2018
13	Acute limb ischemia of the lower extremity associated with left upper lobe surgery for primary lung cancer. ( 29942889 )	Inoue S....Okabayashi K.	2018
14	Simultaneous Hybrid Operation Common Femoral Endarterectomy and Endovascular Treatment in Multilevel Peripheral Arterial Disease with Critical Limb Ischemia. ( 29915480 )	Jung H.J....Lee S.S.	2018
15	Clinical significance of perioperative changes in ankle-brachial index with regard to extremity-related outcome in non-diabetic patients with critical limb ischemia. ( 29911291 )	Bischoff M.S....BAPckler D.	2018
16	Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia. ( 29395424 )	Wang S.K....Murphy M.P.	2018
17	The Role of miR-126 in Critical Limb Ischemia Treatment Using Adipose-Derived Stem Cell Therapeutic Factor Concentrate and Extracellular Matrix Microparticles. ( 29371587 )	ProchA!zka V....Johnstone B.H.	2018
18	MicroRNA-19 restores vascular endothelial cell function in lower limb ischemia-reperfusion injury through the KLF10-dependent TGF-I^1/Smad signaling pathway in rats. ( 29953651 )	Xu Y.L....Wu Y.	2018
19	Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty. ( 29860903 )	Nemcova A....Jude E.B.	2018
20	Pathophysiology of chronic limb ischemia. ( 29950791 )	Simon F....Duran M.	2018
21	Efficacy of regional saturation of oxygen monitor using near-infrared spectroscopy for lower limb ischemia during minimally invasive cardiac surgery. ( 29938392 )	Toya T....Kobayashi J.	2018
22	One-Year Results of First-Line Treatment Strategies in Patients With Critical Limb Ischemia (CRITISCH Registry). ( 29968501 )	Stavroulakis K....Bisdas T.	2018
23	The Incidence, Risk Factors, and Outcomes of Contrast-Induced Nephropathy In Patients With Critical Limb Ischemia Following Lower Limb Angiography. ( 29390867 )	Cury M.V.M....Sacilotto R.	2018
24	Impact of infection severity on clinical outcomes in critical limb ischemia with tissue loss after endovascular treatment. ( 29967952 )	Makino K....Ito Y.	2018
25	Field testing for the critical limb ischemia cost measure. ( 29801561 )	Woo K....Shireman P.K.	2018
26	Outcomes of Duplex guided paramalleolar and inframalleolar bypass in patients with critical limb ischemia. ( 29886216 )	Abualhin M....Gargiulo M.	2018
27	miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia. ( 29908843 )	Besnier M....Spinetti G.	2018
28	Mycotic Renal Artery Aneurysm Presenting as Critical Limb Ischemia in Culture-Negative Endocarditis. ( 29854544 )	Ho V.T....Garcia-Toca M.	2018
29	Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials. ( 29977308 )	Xie B....Xu D.	2018
30	Reinterventions following endovascular revascularization in elderly with critical limb ischemia; an observational study. ( 29886205 )	Klaphake S....van der Laan L.	2018
31	Clinical Outcomes after Isolated Infrapopliteal Revascularization in Hemodialysis Patients with Critical Limb Ischemia: Endovascular Therapy versus Bypass Surgery. ( 29367521 )	Ito R....Murohara T.	2018
32	Disease Burden and Clinical Outcomes Following Initial Diagnosis of Critical Limb Ischemia in the Medicare Population. ( 29798766 )	Mustapha J.A....Jaff M.R.	2018
33	BAD transmission and SAD distribution: a new scenario for critical limb ischemia. ( 29786411 )	Ferraresi R....Neri L.	2018
34	The influence of patients' nutritional status on the prevalence, course and treatment outcomes of lower limb ischemia: an overview of current evidence. ( 29385791 )	Spychalska-ZwoliA8ska M....BudzyA8ski J.	2018
35	Predictive factors of a poor outcome following revascularization for critical limb ischemia: implications for practice. ( 29792018 )	MartA-nez M....ClarA A.	2018
36	Noninvasive measurements of tissue perfusion in critical limb ischemia. ( 29950790 )	Rother U....Lang W.	2018
37	Assessment of Tissue Perfusion with Blood Oxygenation Level-Dependent Magnetic Resonance Imaging in Critical Limb Ischemia. ( 29968440 )	Lee J.Y....Shin M.J.	2018
38	Design Strategies for Global Clinical Trials of Endovascular Devices for Critical Limb Ischemia (CLI)a88- A Joint USA-Japanese Perspective. ( 29962385 )	Yokoi H....Jaff M.R.	2018
39	Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model. ( 29395422 )	Zhang S....Rieben R.	2018
40	Cryptogenic acute limb ischemia: a retrospective cohort study defining a previously undescribed clinical entity. ( 29357035 )	Mart D....DeLoughery T.	2018
41	Endovascular Distal Plantar Vein Arterialization in Dialysis Patients With No-Option Critical Limb Ischemia and Posterior Tibial Artery Occlusion: A Technique for Limb Salvage in a Challenging Patient Subset. ( 29264998 )	Gandini R....Konda D.	2018
42	Recurrence of Critical Limb Ischemia After Endovascular Intervention in Patients with Diabetic Foot Ulcers. ( 29892493 )	Meloni M....Uccioli L.	2018
43	Thrombectomy Using Myocardial Biopsy Forceps in Acute Limb Ischemia Patients. ( 29887182 )	Shimada T....Sato K.	2018
44	Inframalleolar Interventions in Critical Limb Ischemia: Trailblazing the Path Toward the Final Frontier? ( 28057290 )	Mustapha J.A....Diaz-Sandoval L.J.	2017
45	Thrombolytic therapy for critical limb ischemia in a Jehovah's Witness with severe anemia. ( 29349406 )	Kauffman J.D....Campbell J.J.	2017
46	Isolated lower extremity vasculitis leading to progressive critical limb ischemia. ( 29349396 )	Parsa P....Grimsley B.	2017
47	Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation. ( 29410598 )	Foster A.D....Bradley M.J.	2017
48	Staged endovascular repair of critical limb ischemia in high risk patients: the procedural and clinical outcomes. ( 28884985 )	Liu G....Jiang M.	2017
49	Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes. ( 28900239 )	Li J.Y....Jin S.	2017
50	Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects. ( 28789654 )	Giovannini S....Flex A.	2017

Sources

Genes for Limb Ischemia

Genes related to Limb Ischemia (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	23.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	NOS3	Nitric Oxide Synthase 3	Protein Coding	23.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	FGF2	Fibroblast Growth Factor 2	Protein Coding	23.17	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	HGF	Hepatocyte Growth Factor	Protein Coding	22.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	KDR	Kinase Insert Domain Receptor	Protein Coding	22.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL6	Interleukin 6	Protein Coding	22.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	22.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	22.17	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	VWF	Von Willebrand Factor	Protein Coding	21.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	PGF	Placental Growth Factor	Protein Coding	21.57	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	21.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	TNF	Tumor Necrosis Factor	Protein Coding	21.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	ACE	Angiotensin I Converting Enzyme	Protein Coding	21.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	EDN1	Endothelin 1	Protein Coding	21.12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	ANGPT2	Angiopoietin 2	Protein Coding	21.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	TNNI3	Troponin I3, Cardiac Type	Protein Coding	20.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Limb Ischemia

Sources

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Sources

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 59)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁶ Show member pathways GPCR downstream signaling ⁶⁶ Signal Transduction ⁶⁶	14.16	CXCL12 EDN1 FGF2 HGF HIF1A IL6
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.86	ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.71	CXCL12 FGF2 HGF IL6 KDR NOS3
4	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.66	ANGPT2 CXCL12 EDN1 HGF IL6 KDR
5	Activation of cAMP-Dependent PKA ⁶⁴ Show member pathways Activation of PKA through GPCR ⁶⁴ cAMP Pathway ⁶⁴ PKA Signaling ⁶⁴	13.56	CXCL12 FGF2 HGF IL6 KDR NOS3
6	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.47	FGF2 HGF KDR TEK TNF VEGFA
7	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.46	ANGPT2 CXCL12 FGF2 HGF IL6 KDR
8	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.37	FGF2 HGF HIF1A IL6 TEK TNF
9	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	13.33	CXCL12 FGF2 HGF IL6 KDR PGF
10	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.32	ANGPT2 CXCL12 FGF2 HGF IL6 KDR
11	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.31	ANGPT2 CXCL12 FGF2 HGF IL6 KDR
12	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.18	CXCL12 FGF2 HGF IL6 KDR NOS3
13	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13.07	CXCL12 FGF2 HGF IL6 KDR PGF
14	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	13.07	ACE CXCL12 FGF2 HGF HIF1A IL6
15	Focal Adhesion ³⁷ ¹ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.88	HGF KDR PGF VEGFA VWF
16	Pathways in cancer ³⁷	12.87	CXCL12 FGF2 HGF HIF1A IL6 PGF
17	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.77	FGF2 HGF IL6 KDR VEGFA
18	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.76	ANGPT2 FGF2 HGF KDR PGF TEK
19	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.72	CXCL12 FGF2 HGF IL6 KDR PGF
20	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.72	ANGPT2 FGF2 HGF IL6 KDR NOS3
21	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.64	ANGPT2 FGF2 IL6 NOS3 TEK TNF
22	MAPK signaling pathway ¹ ³⁷	12.64	ANGPT2 FGF2 HGF KDR PGF TEK
23	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.62	ANGPT2 FGF2 HIF1A IL6 TNF VEGFA
24	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁷ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁷	12.56	KDR NOS3 TNF VEGFA
25	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.39	KDR NOS3 PGF VEGFA
26	Proteoglycans in cancer ³⁷	12.29	FGF2 HGF HIF1A KDR TNF VEGFA
27	VEGF Signaling Pathway ⁶⁷ ⁶¹ Show member pathways Nanoparticle-mediated activation of receptor signaling ¹ TGF-beta Signaling ⁶⁷	12.25	FGF2 KDR NOS3 VEGFA
28	Dilated cardiomyopathy (DCM) ³⁷ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁷	12.22	ACE IL6 TNF TNNI3
29	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.19	HIF1A IL6 TNF VEGFA
30	Fluid shear stress and atherosclerosis ³⁷	12.15	EDN1 KDR NOS3 TNF VEGFA
31	Tyrosine Kinases / Adaptors ⁴	12.14	ANGPT2 FGF2 KDR TEK
32	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.05	ANGPT2 CXCL12 FGF2 HGF IL6 KDR
33	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12.01	FGF2 HGF IL6 KDR TNNI3 VEGFA
34	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.96	EDN1 IL6 NOS3 TNF VEGFA
35	Insulin resistance ³⁷ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.94	IL6 NOS3 TNF
36	TNF signaling pathway ³⁷	11.93	EDN1 IL6 TNF
37	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.91	HIF1A KDR NOS3 PGF VEGFA
38	Rheumatoid arthritis ³⁷	11.89	CXCL12 IL6 TEK TNF VEGFA
39	Interleukin-4 and 13 signaling ⁶⁶	11.86	FGF2 HGF HIF1A IL6 TNF VEGFA
40	HIF-1 signaling pathway ³⁷	11.8	ANGPT2 EDN1 HIF1A IL6 NOS3 TEK
41	HIF-1-alpha transcription factor network ¹	11.75	CXCL12 EDN1 HIF1A VEGFA
42	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.68	IL6 TNF VEGFA
43	HIF1Alpha Pathway ⁶⁴	11.66	EDN1 HIF1A NOS3 VEGFA
44	Lung fibrosis ¹	11.65	EDN1 FGF2 HGF IL6 TNF
45	Cardiac Progenitor Differentiation ¹	11.6	FGF2 KDR TNNI3
46	Differentiation Pathway ¹	11.6	FGF2 HGF IL6 VEGFA
47	Hepatitis C and Hepatocellular Carcinoma ¹	11.58	HIF1A IL6 VEGFA
48	Cell adhesion_Plasmin signaling ²²	11.56	FGF2 KDR VEGFA
49	Malaria ³⁷	11.56	HGF IL6 TNF
50	Integrins in angiogenesis ¹	11.52	FGF2 KDR VEGFA

Sources

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.65	ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2	extracellular region	GO:0005576	9.44	ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
3	platelet alpha granule lumen	GO:0031093	9.43	HGF VEGFA VWF
4	Weibel-Palade body	GO:0033093	9.16	EDN1 VWF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	9.99	HIF1A KDR TNF VEGFA
2	extracellular matrix organization	GO:0030198	9.98	FGF2 KDR TNF VWF
3	cytokine-mediated signaling pathway	GO:0019221	9.97	FGF2 HGF HIF1A IL6 TNF VEGFA
4	regulation of signaling receptor activity	GO:0010469	9.97	CXCL12 EDN1 FGF2 HGF IL6 PGF
5	positive regulation of cell migration	GO:0030335	9.96	CXCL12 EDN1 HGF KDR VEGFA
6	peptidyl-tyrosine phosphorylation	GO:0018108	9.94	FGF2 HGF KDR TEK
7	positive regulation of protein kinase B signaling	GO:0051897	9.93	FGF2 HGF TEK TNF
8	positive regulation of protein phosphorylation	GO:0001934	9.91	HGF KDR TEK TNF VEGFA
9	activation of MAPK activity	GO:0000187	9.9	FGF2 HGF TNF
10	cellular response to hypoxia	GO:0071456	9.9	EDN1 HIF1A VEGFA
11	positive regulation of DNA binding transcription factor activity	GO:0051091	9.89	EDN1 IL6 TNF
12	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.89	HGF IL6 VEGFA
13	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.88	IL6 TNF VEGFA
14	regulation of blood pressure	GO:0008217	9.87	ACE EDN1 NOS3
15	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.87	KDR PGF VEGFA
16	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.87	HGF KDR TEK
17	vasculogenesis	GO:0001570	9.85	KDR TNNI3 VEGFA
18	positive regulation of smooth muscle cell proliferation	GO:0048661	9.84	EDN1 IL6 TNF
19	positive regulation of MAP kinase activity	GO:0043406	9.83	EDN1 FGF2 TNF VEGFA
20	positive regulation of cell adhesion	GO:0045785	9.82	CXCL12 TNF VEGFA
21	positive regulation of cell division	GO:0051781	9.82	FGF2 PGF VEGFA
22	response to hypoxia	GO:0001666	9.8	ANGPT2 CXCL12 EDN1 HIF1A PGF TEK
23	positive regulation of cell migration involved in sprouting angiogenesis	GO:0090050	9.78	FGF2 KDR VEGFA
24	positive regulation of endothelial cell migration	GO:0010595	9.78	EDN1 KDR TEK VEGFA
25	blood vessel morphogenesis	GO:0048514	9.76	ANGPT2 EDN1 HIF1A
26	animal organ regeneration	GO:0031100	9.76	ANGPT2 CXCL12 HGF PGF
27	angiogenesis	GO:0001525	9.76	ANGPT2 FGF2 HIF1A KDR NOS3 PGF
28	positive regulation of focal adhesion assembly	GO:0051894	9.75	KDR TEK VEGFA
29	positive regulation of chemokine production	GO:0032722	9.74	HIF1A IL6 TNF
30	positive chemotaxis	GO:0050918	9.73	CXCL12 FGF2 HGF VEGFA
31	embryonic hemopoiesis	GO:0035162	9.72	HIF1A KDR
32	cell migration involved in sprouting angiogenesis	GO:0002042	9.72	FGF2 KDR VEGFA
33	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.72	FGF2 HIF1A KDR NOS3 VEGFA
34	heart contraction	GO:0060047	9.71	ACE TNNI3
35	positive regulation of positive chemotaxis	GO:0050927	9.71	KDR VEGFA
36	induction of positive chemotaxis	GO:0050930	9.71	CXCL12 PGF VEGFA
37	neutrophil mediated immunity	GO:0002446	9.7	ACE IL6
38	negative regulation of lipid storage	GO:0010888	9.7	IL6 TNF
39	positive regulation of axon extension involved in axon guidance	GO:0048842	9.68	CXCL12 VEGFA
40	positive regulation of receptor biosynthetic process	GO:0010870	9.68	EDN1 HIF1A
41	positive regulation of mast cell chemotaxis	GO:0060754	9.67	PGF VEGFA
42	regulation of systemic arterial blood pressure by endothelin	GO:0003100	9.67	EDN1 NOS3
43	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061419	9.66	HIF1A VEGFA
44	positive regulation of peptidyl-tyrosine autophosphorylation	GO:1900086	9.65	ACE VEGFA
45	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	GO:0038033	9.65	KDR VEGFA
46	glomerulus vasculature development	GO:0072012	9.63	ANGPT2 TEK
47	Tie signaling pathway	GO:0048014	9.62	ANGPT2 TEK
48	positive regulation of chemokine-mediated signaling pathway	GO:0070101	9.59	EDN1 HIF1A
49	positive regulation of endothelial cell proliferation	GO:0001938	9.5	CXCL12 FGF2 HIF1A KDR PGF TEK
50	positive regulation of angiogenesis	GO:0045766	9.28	ANGPT2 FGF2 HGF HIF1A KDR NOS3

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:0004713	9.67	FGF2 HGF KDR TEK
2	Ras guanyl-nucleotide exchange factor activity	GO:0005088	9.61	FGF2 HGF TEK
3	mitogen-activated protein kinase kinase binding	GO:0031434	9.58	ACE KDR TEK
4	integrin binding	GO:0005178	9.56	CXCL12 FGF2 KDR VWF
5	chemoattractant activity	GO:0042056	9.46	CXCL12 FGF2 HGF VEGFA
6	cytokine activity	GO:0005125	9.43	CXCL12 EDN1 FGF2 IL6 TNF VEGFA
7	vascular endothelial growth factor receptor binding	GO:0005172	9.32	PGF VEGFA
8	growth factor activity	GO:0008083	9.1	CXCL12 FGF2 HGF IL6 PGF VEGFA

Sources

Sources for Limb Ischemia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia