MCID: LMB062
MIFTS: 53

Limb Ischemia

Categories: Cardiovascular diseases

Aliases & Classifications for Limb Ischemia

MalaCards integrated aliases for Limb Ischemia:

Name: Limb Ischemia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050852
UMLS 73 C2945695

Summaries for Limb Ischemia

MalaCards based summary : Limb Ischemia is related to critical limb ischemia and ischemia. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Aspirin and Povidone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related phenotypes are cardiovascular system and cellular

Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 critical limb ischemia 34.0 HGF IL6 TEK TNF VEGFA
2 ischemia 31.3 ACE CXCL12 EDN1 HIF1A NOS3 VEGFA
3 peripheral artery disease 30.4 ACE IL6 NOS3 VEGFA
4 peripheral vascular disease 30.3 ACE IL6 VEGFA VWF
5 endocarditis 30.2 IL6 TNF TNNI3
6 intermittent claudication 30.0 ACE ANGPT2 IL6 VEGFA VWF
7 diabetes mellitus 29.9 ACE EDN1 IL6 NOS3 TNF VEGFA
8 cardiogenic shock 29.9 IL6 TNF
9 chronic kidney failure 29.9 ACE EDN1 IL6 NOS3
10 purpura 29.8 IL6 TNF VWF
11 infective endocarditis 29.7 IL6 TNF TNNI3
12 coronary artery anomaly 29.7 ACE EDN1 NOS3 TNNI3
13 connective tissue disease 29.6 ACE EDN1 IL6 TNF
14 end stage renal failure 29.5 ACE IL6 TNF
15 arteries, anomalies of 29.5 ACE EDN1 IL6 NOS3 PGF TNF
16 arteriosclerosis 29.4 ACE EDN1 HGF IL6
17 vascular disease 29.3 ACE EDN1 FGF2 IL6 NOS3 TNF
18 acute myocardial infarction 29.1 ACE EDN1 TNNI3 VWF
19 dilated cardiomyopathy 28.9 ACE EDN1 IL6 NOS3 TNF TNNI3
20 microvascular complications of diabetes 5 28.5 ACE ANGPT2 FGF2 KDR NOS3 PGF
21 myocardial infarction 28.1 ACE CXCL12 EDN1 HIF1A IL6 NOS3
22 scorpion envenomation 10.3 IL6 TNF
23 intravascular papillary endothelial hyperplasia 10.3 HIF1A VEGFA
24 hemifacial spasm 10.3 NOS3 VEGFA
25 wrinkles 10.3 HGF VEGFA
26 leukomalacia 10.2 IL6 TNF
27 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
28 patellar tendinitis 10.2 NOS3 VEGFA
29 poems syndrome 10.2 IL6 TNF VEGFA
30 streptococcal toxic-shock syndrome 10.2 IL6 TNF
31 eales disease 10.2 IL6 TNF VEGFA
32 juvenile ankylosing spondylitis 10.2 IL6 TNF
33 rosacea 10.2 IL6 TNF VEGFA
34 infiltrating angiolipoma 10.2 VEGFA VWF
35 laryngitis 10.2 FGF2 IL6 TNF
36 female reproductive system disease 10.2 IL6 TNF VEGFA
37 buerger disease 10.2
38 thrombosis 10.2
39 hypoxia 10.2
40 reproductive system disease 10.2 IL6 TNF VEGFA
41 kashin-beck disease 10.2 TNF VEGFA
42 angiokeratoma circumscriptum 10.2 KDR VEGFA
43 osteosclerotic myeloma 10.2 IL6 TNF VWF
44 chronic mountain sickness 10.2 EDN1 NOS3 VEGFA
45 intestinal disease 10.2 IL6 TNF VEGFA
46 endometrial adenocarcinoma 10.2 FGF2 HIF1A VEGFA
47 respiratory system disease 10.2 IL6 TNF VEGFA
48 meconium aspiration syndrome 10.2 EDN1 IL6 TNF
49 lymphangiosarcoma 10.2 TNF VEGFA VWF
50 varicose veins 10.2 HIF1A VEGFA VWF

Graphical network of the top 20 diseases related to Limb Ischemia:



Diseases related to Limb Ischemia

Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2 cellular MP:0005384 10.29 ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3 homeostasis/metabolism MP:0005376 10.29 ACE ANGPT2 EDN1 FGF2 HIF1A IL6
4 mortality/aging MP:0010768 10.28 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
5 hematopoietic system MP:0005397 10.27 ACE CXCL12 FGF2 HGF HIF1A IL6
6 growth/size/body region MP:0005378 10.25 ACE EDN1 HGF HIF1A IL6 KDR
7 immune system MP:0005387 10.2 ACE ANGPT2 CXCL12 HIF1A IL6 KDR
8 digestive/alimentary MP:0005381 10.14 ANGPT2 EDN1 HIF1A IL6 NOS3 TNF
9 embryo MP:0005380 10.13 EDN1 HGF HIF1A KDR PGF TEK
10 muscle MP:0005369 10.11 CXCL12 EDN1 FGF2 HIF1A IL6 KDR
11 liver/biliary system MP:0005370 10.09 ACE CXCL12 HGF HIF1A IL6 KDR
12 nervous system MP:0003631 10 CXCL12 EDN1 FGF2 HIF1A IL6 KDR
13 neoplasm MP:0002006 9.87 ACE FGF2 HIF1A IL6 PGF TNF
14 respiratory system MP:0005388 9.81 ANGPT2 HIF1A IL6 KDR NOS3 PGF
15 skeleton MP:0005390 9.56 EDN1 FGF2 HIF1A IL6 KDR NOS3
16 vision/eye MP:0005391 9.32 ANGPT2 FGF2 HIF1A IL6 KDR NOS3

Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 249)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable 50-78-2 2244
2
Povidone Approved Phase 4 9003-39-8
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
5
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
6
Teicoplanin Approved, Investigational Phase 4 61036-62-2
7
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
8
Metronidazole Approved Phase 4 443-48-1 4173
9
Povidone-iodine Approved Phase 4 25655-41-8
10
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
11
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 33069-62-4 36314
12
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 9005-49-6 772 46507594
13
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 113665-84-2, 120202-66-6 60606
14
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
15
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2 73963-72-1 2754
16
Lenograstim Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 135968-09-1
17
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351 5280723
18
Menthol Approved Phase 4 2216-51-5 16666
19
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
20
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2 1177-87-3
21
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
22
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
23
Dalteparin Approved Phase 4,Phase 2 9005-49-6
24
Defibrotide Approved, Investigational Phase 4 83712-60-1
25
Ramipril Approved Phase 4 87333-19-5 5362129
26
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 94-09-7, 1994-09-7 2337
27 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1
28
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6
29
Febuxostat Approved Phase 4 144060-53-7 134018
30
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
31
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
32
Insulin Glargine Approved Phase 4 160337-95-1
33
Phenylephrine Approved Phase 4 59-42-7 6041
34
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
35
Ephedrine Approved Phase 4 299-42-3 9294
36
Norepinephrine Approved Phase 4 51-41-2 439260
37
Pseudoephedrine Approved Phase 4 90-82-4 7028
38
Uric Acid Experimental, Investigational Phase 4 69-93-2 1175
39 Antibiotics, Antitubercular Phase 4,Phase 2,Not Applicable
40 Antiparasitic Agents Phase 4
41 penicillins Phase 4
42 Clindamycin phosphate Phase 4
43 Antitubercular Agents Phase 4
44 Micronutrients Phase 4,Not Applicable
45 Antiprotozoal Agents Phase 4
46 Gentamicins Phase 4
47 Anti-Infective Agents, Local Phase 4,Not Applicable
48 Clindamycin palmitate Phase 4
49 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
50 beta-Lactamase Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 495)
# Name Status NCT ID Phase Drugs
1 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Unknown status NCT01173094 Phase 4
2 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) Unknown status NCT01171703 Phase 4
3 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Unknown status NCT02563535 Phase 4
4 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
5 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
6 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
7 Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery Unknown status NCT02085551 Phase 4
8 Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) Completed NCT00906022 Phase 4
9 Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia Completed NCT02369809 Phase 4 Neovasculgen®
10 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation Completed NCT01558505 Phase 4
11 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
12 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
13 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV Completed NCT00596752 Phase 4 Alprostadil
14 DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
15 Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) Completed NCT00300690 Phase 4
16 Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions Completed NCT00764777 Phase 4
17 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
18 Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans Completed NCT02117206 Phase 4 L-arginine (L-arginine Veyron);Nacl
19 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Completed NCT01983449 Phase 4 Dexamethasone Sodium Phosphate Injection, USP
20 AngioSeal Versus Radial Approach in Acute Coronary Syndrome Completed NCT01653587 Phase 4
21 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
22 Instrumental Sealing of Arterial Puncture Site Closure Device Versus Manual Compression Trial Completed NCT01389375 Phase 4
23 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
24 Optimization of Treatment in Patients With Severe Peripheral Ischemia (Fontaine Stage IIb) Completed NCT01718288 Phase 4 iloprost;Standard Treatment (aspirin.....),
25 Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants Completed NCT01037530 Phase 4 Ramipril
26 The Study to Compare SMART Nitinol Stent and Balloon Angioplasty Completed NCT00309595 Phase 4
27 The Study to Compare the Cordis SMART™ Stent System With the Bard® Luminexx™ Stent Completed NCT00235131 Phase 4
28 DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions Completed NCT01412463 Phase 4
29 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Recruiting NCT02829151 Phase 4 Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
30 Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Recruiting NCT02807779 Phase 4 Dexamethasone infusion
31 Lowering-hyperuricemia Treatment on Cardiovascular Outcomes in Peritoneal Dialysis Patients Recruiting NCT03200210 Phase 4 Febuxostat;Placebo
32 Vascular Closure Device Versus Transradial Approach in Primary Percutaneous Coronary Intervention Recruiting NCT02831166 Phase 4
33 Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE) Recruiting NCT03549923 Phase 4 Esmolol;Standard care
34 The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial Recruiting NCT03668236 Phase 4 Isotonic crystalloids
35 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Terminated NCT00403780 Phase 4 pregabalin;placebo
36 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
37 Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty Terminated NCT01150617 Phase 4 Insulin glargine plus insulin analogues
38 Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients Terminated NCT02203630 Phase 4 Phenylephrine;Norepinephrine
39 AGIR Study: Angio-Seal in Interventional Radiology Terminated NCT01911403 Phase 4
40 Use Art-assist and Neupogen to Treat Chronic Limb Ischemia Withdrawn NCT02408991 Phase 4 Neupogen
41 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia Unknown status NCT00539266 Phase 2, Phase 3
42 VADOplex Critical Limb Ischemia Study Unknown status NCT02034539 Phase 2, Phase 3
43 Distal Venous Arterialisation of Ischemic Limb Unknown status NCT01211925 Phase 2, Phase 3 Aspirin
44 Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Unknown status NCT00434616 Phase 2, Phase 3
45 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
46 Effects of Prolonged DAPT After Lower Extremity Percutaneous Transluminal Angioplasty (PTA) in Patients With LE-PAD Unknown status NCT02798913 Phase 3 Short DAPT;Long DAPT
47 Transfusion Requirements in Critically Ill Oncologic Patient Unknown status NCT01648946 Phase 3
48 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
49 Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI Unknown status NCT03001960 Phase 3 Preloading before TAVI;Postloading after TAVI
50 Claudication: Exercise Versus Endoluminal Revascularization (CLEVER) Unknown status NCT00132743 Phase 3 Cilostazol

Search NIH Clinical Center for Limb Ischemia

Genetic Tests for Limb Ischemia

Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

41
Bone, Bone Marrow, Endothelial, Heart, Kidney, Lung, Liver

Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 1579)
# Title Authors Year
1
Human primary CD34<sup>+</sup> cells transplantation for critical limb ischemia. ( 29893031 )
2018
2
Acute Limb Ischemia Secondary to Native Artery Occlusion: Results of a Contemporary Case Series. ( 29404750 )
2018
3
Efficacy Outcomes of Endovascular Versus Surgical Revascularization in Critical Limb Ischemia: Results From a Prospective Cohort Study. ( 29355026 )
2018
4
Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. ( 29373539 )
2018
5
Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion. ( 29960153 )
2018
6
Lower limb ischemia due to popliteal artery compression by Baker cyst. ( 29942891 )
2018
7
Lower extremity bypass and endovascular intervention for critical limb ischemia fail to meet Society for Vascular Surgery's objective performance goals for limb-related outcomes in a contemporary national cohort. ( 29937289 )
2018
8
Rationale and design of the SAIL trial for intramuscular injection of allogeneic mesenchymal stromal cells in no-option critical limb ischemia. ( 29242062 )
2018
9
Natural language processing of clinical notes for identification of critical limb ischemia. ( 29425639 )
2018
10
Spinal Cord Stimulation Improves the Microvascular Perfusion Insufficiency Caused by Critical Limb Ischemia. ( 29377343 )
2018
11
Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia. ( 29796803 )
2018
12
Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan. ( 29386474 )
2018
13
Acute limb ischemia of the lower extremity associated with left upper lobe surgery for primary lung cancer. ( 29942889 )
2018
14
Simultaneous Hybrid Operation Common Femoral Endarterectomy and Endovascular Treatment in Multilevel Peripheral Arterial Disease with Critical Limb Ischemia. ( 29915480 )
2018
15
Clinical significance of perioperative changes in ankle-brachial index with regard to extremity-related outcome in non-diabetic patients with critical limb ischemia. ( 29911291 )
2018
16
Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia. ( 29395424 )
2018
17
The Role of miR-126 in Critical Limb Ischemia Treatment Using Adipose-Derived Stem Cell Therapeutic Factor Concentrate and Extracellular Matrix Microparticles. ( 29371587 )
2018
18
MicroRNA-19 restores vascular endothelial cell function in lower limb ischemia-reperfusion injury through the KLF10-dependent TGF-I^1/Smad signaling pathway in rats. ( 29953651 )
2018
19
Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty. ( 29860903 )
2018
20
Pathophysiology of chronic limb ischemia. ( 29950791 )
2018
21
Efficacy of regional saturation of oxygen monitor using near-infrared spectroscopy for lower limb ischemia during minimally invasive cardiac surgery. ( 29938392 )
2018
22
One-Year Results of First-Line Treatment Strategies in Patients With Critical Limb Ischemia (CRITISCH Registry). ( 29968501 )
2018
23
The Incidence, Risk Factors, and Outcomes of Contrast-Induced Nephropathy In Patients With Critical Limb Ischemia Following Lower Limb Angiography. ( 29390867 )
2018
24
Impact of infection severity on clinical outcomes in critical limb ischemia with tissue loss after endovascular treatment. ( 29967952 )
2018
25
Field testing for the critical limb ischemia cost measure. ( 29801561 )
2018
26
Outcomes of Duplex guided paramalleolar and inframalleolar bypass in patients with critical limb ischemia. ( 29886216 )
2018
27
miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia. ( 29908843 )
2018
28
Mycotic Renal Artery Aneurysm Presenting as Critical Limb Ischemia in Culture-Negative Endocarditis. ( 29854544 )
2018
29
Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials. ( 29977308 )
2018
30
Reinterventions following endovascular revascularization in elderly with critical limb ischemia; an observational study. ( 29886205 )
2018
31
Clinical Outcomes after Isolated Infrapopliteal Revascularization in Hemodialysis Patients with Critical Limb Ischemia: Endovascular Therapy versus Bypass Surgery. ( 29367521 )
2018
32
Disease Burden and Clinical Outcomes Following Initial Diagnosis of Critical Limb Ischemia in the Medicare Population. ( 29798766 )
2018
33
BAD transmission and SAD distribution: a new scenario for critical limb ischemia. ( 29786411 )
2018
34
The influence of patients' nutritional status on the prevalence, course and treatment outcomes of lower limb ischemia: an overview of current evidence. ( 29385791 )
2018
35
Predictive factors of a poor outcome following revascularization for critical limb ischemia: implications for practice. ( 29792018 )
2018
36
Noninvasive measurements of tissue perfusion in critical limb ischemia. ( 29950790 )
2018
37
Assessment of Tissue Perfusion with Blood Oxygenation Level-Dependent Magnetic Resonance Imaging in Critical Limb Ischemia. ( 29968440 )
2018
38
Design Strategies for Global Clinical Trials of Endovascular Devices for Critical Limb Ischemia (CLI)a88- A Joint USA-Japanese Perspective. ( 29962385 )
2018
39
Successful Simultaneous Revascularization for Acute Limb Ischemia and Concomitant Acute Myocardial Infarction. ( 30402191 )
2018
40
An Unusual Case of Acute Thrombosis of Abdominal Aortic Aneurysm without Acute Limb Ischemia. ( 30079935 )
2018
41
Outcomes in Patients with Critical Limb Ischemia due to Arteriosclerosis Obliterans Who Did Not Undergo Arterial Reconstruction. ( 30101855 )
2018
42
Length and Cost of Hospital Stay in Poor-Risk Patients With Critical Limb Ischemia Undergoing Revascularization. ( 30012928 )
2018
43
Percutaneous Deep Venous Arterialization for Severe Critical Limb Ischemia in Patients With No Option of Revascularization: Early Experience From Two European Centers. ( 30019194 )
2018
44
Open Versus Endovascular Revascularization of Below-Knee Arteries in Patients With End-Stage Renal Disease and Critical Limb Ischemia. ( 30021493 )
2018
45
Autologous Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood CD34 Positive Cell Transplantation for Hemodialysis Patients with Critical Limb Ischemia: A Prospective Phase II Clinical Trial. ( 30059194 )
2018
46
Treatment of Nonreconstructable Critical Limb Ischemia With Ischemic Wounds Utilizing a Noninvasive Intermittent Pneumatic Compression Device Monitored With Fluorescence Angiography. ( 30059338 )
2018
47
Correction to: Percutaneous Deep Venous Arterialization for Severe Critical Limb Ischemia in Patients With No Option of Revascularization: Early Experience From Two European Centers. ( 30062443 )
2018
48
Comparison of the Cost of Drug-Eluting Stents versus Bare Metal Stents in the Treatment of Critical Limb Ischemia in the United States. ( 30092444 )
2018
49
Contemporary Management of Critical Limb Ischemia. ( 30098617 )
2018
50
Evaluation of the BASIL Survival Prediction Model in Patients Undergoing Infrapopliteal Interventions for Critical Limb Ischemia. ( 30099169 )
2018

Variations for Limb Ischemia

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.17 CXCL12 EDN1 FGF2 HGF HIF1A IL6
2
Show member pathways
13.86 ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3
Show member pathways
13.72 CXCL12 FGF2 HGF IL6 KDR NOS3
4
Show member pathways
13.68 ANGPT2 CXCL12 EDN1 HGF IL6 KDR
5
Show member pathways
13.58 CXCL12 FGF2 HGF IL6 KDR NOS3
6
Show member pathways
13.55 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
7
Show member pathways
13.48 FGF2 HGF KDR TEK TNF VEGFA
8
Show member pathways
13.38 FGF2 HGF HIF1A IL6 TEK TNF
9
Show member pathways
13.37 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
10
Show member pathways
13.34 CXCL12 FGF2 HGF IL6 KDR PGF
11
Show member pathways
13.32 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
12
Show member pathways
13.29 ANGPT2 HGF NOS3 TEK VEGFA VWF
13
Show member pathways
13.21 CXCL12 FGF2 HGF IL6 KDR NOS3
14
Show member pathways
13.09 ANGPT2 CXCL12 FGF2 HIF1A IL6 TNF
15
Show member pathways
13.08 CXCL12 FGF2 HGF IL6 KDR PGF
16
Show member pathways
13.08 ACE CXCL12 FGF2 HGF HIF1A IL6
17
Show member pathways
12.89 HGF KDR PGF VEGFA VWF
18 12.89 CXCL12 FGF2 HGF HIF1A IL6 PGF
19
Show member pathways
12.79 FGF2 HGF IL6 KDR VEGFA
20
Show member pathways
12.77 ANGPT2 FGF2 HGF KDR PGF TEK
21
Show member pathways
12.74 ANGPT2 FGF2 HGF IL6 KDR NOS3
22
Show member pathways
12.73 CXCL12 FGF2 HGF IL6 KDR PGF
23 12.67 ANGPT2 FGF2 HGF KDR PGF TEK
24
Show member pathways
12.65 ANGPT2 FGF2 IL6 NOS3 TEK TNF
25
Show member pathways
12.57 KDR NOS3 TNF VEGFA
26
Show member pathways
12.45 CXCL12 FGF2 HGF IL6 KDR PGF
27
Show member pathways
12.4 KDR NOS3 PGF VEGFA
28 12.32 FGF2 HGF HIF1A KDR TNF VEGFA
29
Show member pathways
12.25 FGF2 KDR NOS3 VEGFA
30
Show member pathways
12.25 CXCL12 FGF2 HGF IL6 KDR PGF
31
Show member pathways
12.24 ACE IL6 TNF TNNI3
32 12.21 HIF1A IL6 TNF VEGFA
33 12.17 EDN1 KDR NOS3 TNF VEGFA
34 12.16 ANGPT2 FGF2 KDR TEK
35
Show member pathways
12.07 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
36 12.03 FGF2 HGF IL6 KDR TNNI3 VEGFA
37 11.97 EDN1 IL6 NOS3 TNF VEGFA
38 11.95 EDN1 IL6 TNF
39
Show member pathways
11.94 IL6 NOS3 TNF
40
Show member pathways
11.92 HIF1A KDR NOS3 PGF VEGFA
41 11.9 CXCL12 IL6 TEK TNF VEGFA
42 11.9 FGF2 HGF HIF1A IL6 TNF VEGFA
43 11.8 ANGPT2 EDN1 HIF1A IL6 NOS3 TEK
44 11.77 CXCL12 FGF2 HGF IL6 PGF
45 11.76 CXCL12 EDN1 HIF1A VEGFA
46
Show member pathways
11.7 IL6 TNF VEGFA
47 11.67 EDN1 HIF1A NOS3 VEGFA
48 11.67 EDN1 FGF2 HGF IL6 TNF
49 11.62 FGF2 KDR TNNI3
50 11.62 FGF2 HGF IL6 VEGFA

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2 extracellular region GO:0005576 9.44 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
3 platelet alpha granule lumen GO:0031093 9.43 HGF VEGFA VWF
4 Weibel-Palade body GO:0033093 9.16 EDN1 VWF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.97 FGF2 HGF KDR TEK
2 positive regulation of cell migration GO:0030335 9.97 CXCL12 EDN1 HGF KDR VEGFA
3 regulation of signaling receptor activity GO:0010469 9.97 CXCL12 EDN1 FGF2 HGF IL6 PGF
4 positive regulation of protein kinase B signaling GO:0051897 9.96 FGF2 HGF TEK TNF
5 cytokine-mediated signaling pathway GO:0019221 9.93 FGF2 HGF HIF1A IL6 TNF VEGFA
6 activation of MAPK activity GO:0000187 9.91 FGF2 HGF TNF
7 negative regulation of gene expression GO:0010629 9.91 ACE EDN1 HIF1A KDR TNF VEGFA
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 EDN1 IL6 TNF
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 HGF IL6 VEGFA
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 IL6 TNF VEGFA
11 regulation of blood pressure GO:0008217 9.88 ACE EDN1 NOS3
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.88 KDR PGF VEGFA
13 positive regulation of protein phosphorylation GO:0001934 9.88 HGF KDR PGF TEK TNF VEGFA
14 vasculogenesis GO:0001570 9.87 KDR TNNI3 VEGFA
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 EDN1 IL6 TNF
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.86 HGF KDR TEK TNF
17 positive regulation of cell adhesion GO:0045785 9.85 CXCL12 TNF VEGFA
18 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.84 EDN1 FGF2 TNF
19 positive regulation of cell division GO:0051781 9.84 FGF2 PGF VEGFA
20 positive regulation of MAP kinase activity GO:0043406 9.84 EDN1 FGF2 TNF VEGFA
21 positive regulation of endothelial cell migration GO:0010595 9.83 EDN1 KDR TEK VEGFA
22 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.82 FGF2 KDR VEGFA
23 sprouting angiogenesis GO:0002040 9.8 PGF TEK VEGFA
24 positive chemotaxis GO:0050918 9.8 FGF2 HGF PGF VEGFA
25 response to hypoxia GO:0001666 9.8 ANGPT2 CXCL12 EDN1 HIF1A PGF TEK
26 blood vessel morphogenesis GO:0048514 9.79 ANGPT2 EDN1 HIF1A
27 animal organ regeneration GO:0031100 9.78 ANGPT2 CXCL12 HGF PGF
28 positive regulation of focal adhesion assembly GO:0051894 9.77 KDR TEK VEGFA
29 cell migration involved in sprouting angiogenesis GO:0002042 9.77 FGF2 KDR VEGFA
30 positive regulation of chemokine production GO:0032722 9.76 HIF1A IL6 TNF
31 angiogenesis GO:0001525 9.76 ANGPT2 FGF2 HIF1A KDR NOS3 PGF
32 vascular endothelial growth factor signaling pathway GO:0038084 9.74 KDR PGF VEGFA
33 positive regulation of glial cell proliferation GO:0060252 9.73 IL6 TNF
34 embryonic hemopoiesis GO:0035162 9.73 HIF1A KDR
35 heart contraction GO:0060047 9.73 ACE TNNI3
36 positive regulation of DNA biosynthetic process GO:2000573 9.73 FGF2 HGF
37 positive regulation of positive chemotaxis GO:0050927 9.72 KDR VEGFA
38 negative regulation of lipid storage GO:0010888 9.72 IL6 TNF
39 induction of positive chemotaxis GO:0050930 9.72 CXCL12 PGF VEGFA
40 positive regulation of blood vessel endothelial cell migration GO:0043536 9.72 FGF2 HIF1A KDR NOS3 VEGFA
41 neutrophil mediated immunity GO:0002446 9.71 ACE IL6
42 positive regulation of axon extension involved in axon guidance GO:0048842 9.71 CXCL12 VEGFA
43 positive regulation of receptor biosynthetic process GO:0010870 9.71 EDN1 HIF1A
44 positive regulation of mast cell chemotaxis GO:0060754 9.69 PGF VEGFA
45 positive regulation of neuroinflammatory response GO:0150078 9.69 IL6 TNF
46 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.69 EDN1 NOS3
47 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.68 KDR VEGFA
48 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.68 HIF1A VEGFA
49 glomerulus vasculature development GO:0072012 9.65 ANGPT2 TEK
50 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.65 ACE VEGFA

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.62 FGF2 HGF KDR TEK
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.61 FGF2 HGF TEK
3 integrin binding GO:0005178 9.56 CXCL12 FGF2 KDR VWF
4 chemoattractant activity GO:0042056 9.46 FGF2 HGF PGF VEGFA
5 cytokine activity GO:0005125 9.43 CXCL12 EDN1 FGF2 IL6 TNF VEGFA
6 vascular endothelial growth factor receptor 3 binding GO:0043185 9.4 PGF VEGFA
7 growth factor activity GO:0008083 9.1 CXCL12 FGF2 HGF IL6 PGF VEGFA
8 protein binding GO:0005515 10.24 ANGPT2 CXCL12 EDN1 FGF2 HGF HIF1A

Sources for Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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