Limb Ischemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LMB062 MIFTS: 53	Limb Ischemia Categories: Cardiovascular diseases
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Aliases & Classifications for Limb Ischemia

MalaCards integrated aliases for Limb Ischemia:

Name: Limb Ischemia ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050852

UMLS ⁷³ C2945695

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Summaries for Limb Ischemia

MalaCards based summary : Limb Ischemia is related to critical limb ischemia and ischemia. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Aspirin and Povidone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related phenotypes are cardiovascular system and cellular

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Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)

#	Related Disease	Score	Top Affiliating Genes
1	critical limb ischemia	34.0	HGF IL6 TEK TNF VEGFA
2	ischemia	31.3	ACE CXCL12 EDN1 HIF1A NOS3 VEGFA
3	peripheral artery disease	30.4	ACE IL6 NOS3 VEGFA
4	peripheral vascular disease	30.3	ACE IL6 VEGFA VWF
5	endocarditis	30.2	IL6 TNF TNNI3
6	intermittent claudication	30.0	ACE ANGPT2 IL6 VEGFA VWF
7	diabetes mellitus	29.9	ACE EDN1 IL6 NOS3 TNF VEGFA
8	cardiogenic shock	29.9	IL6 TNF
9	chronic kidney failure	29.9	ACE EDN1 IL6 NOS3
10	purpura	29.8	IL6 TNF VWF
11	infective endocarditis	29.7	IL6 TNF TNNI3
12	coronary artery anomaly	29.7	ACE EDN1 NOS3 TNNI3
13	connective tissue disease	29.6	ACE EDN1 IL6 TNF
14	end stage renal failure	29.5	ACE IL6 TNF
15	arteries, anomalies of	29.5	ACE EDN1 IL6 NOS3 PGF TNF
16	arteriosclerosis	29.4	ACE EDN1 HGF IL6
17	vascular disease	29.3	ACE EDN1 FGF2 IL6 NOS3 TNF
18	acute myocardial infarction	29.1	ACE EDN1 TNNI3 VWF
19	dilated cardiomyopathy	28.9	ACE EDN1 IL6 NOS3 TNF TNNI3
20	microvascular complications of diabetes 5	28.5	ACE ANGPT2 FGF2 KDR NOS3 PGF
21	myocardial infarction	28.1	ACE CXCL12 EDN1 HIF1A IL6 NOS3
22	scorpion envenomation	10.3	IL6 TNF
23	intravascular papillary endothelial hyperplasia	10.3	HIF1A VEGFA
24	hemifacial spasm	10.3	NOS3 VEGFA
25	wrinkles	10.3	HGF VEGFA
26	leukomalacia	10.2	IL6 TNF
27	angioimmunoblastic lymphadenopathy with dysproteinemia	10.2	IL6 TNF
28	patellar tendinitis	10.2	NOS3 VEGFA
29	poems syndrome	10.2	IL6 TNF VEGFA
30	streptococcal toxic-shock syndrome	10.2	IL6 TNF
31	eales disease	10.2	IL6 TNF VEGFA
32	juvenile ankylosing spondylitis	10.2	IL6 TNF
33	rosacea	10.2	IL6 TNF VEGFA
34	infiltrating angiolipoma	10.2	VEGFA VWF
35	laryngitis	10.2	FGF2 IL6 TNF
36	female reproductive system disease	10.2	IL6 TNF VEGFA
37	buerger disease	10.2
38	thrombosis	10.2
39	hypoxia	10.2
40	reproductive system disease	10.2	IL6 TNF VEGFA
41	kashin-beck disease	10.2	TNF VEGFA
42	angiokeratoma circumscriptum	10.2	KDR VEGFA
43	osteosclerotic myeloma	10.2	IL6 TNF VWF
44	chronic mountain sickness	10.2	EDN1 NOS3 VEGFA
45	intestinal disease	10.2	IL6 TNF VEGFA
46	endometrial adenocarcinoma	10.2	FGF2 HIF1A VEGFA
47	respiratory system disease	10.2	IL6 TNF VEGFA
48	meconium aspiration syndrome	10.2	EDN1 IL6 TNF
49	lymphangiosarcoma	10.2	TNF VEGFA VWF
50	varicose veins	10.2	HIF1A VEGFA VWF

Graphical network of the top 20 diseases related to Limb Ischemia:

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Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

⁴⁶ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.46	ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2	cellular	MP:0005384	10.29	ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3	homeostasis/metabolism	MP:0005376	10.29	ACE ANGPT2 EDN1 FGF2 HIF1A IL6
4	mortality/aging	MP:0010768	10.28	ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
5	hematopoietic system	MP:0005397	10.27	ACE CXCL12 FGF2 HGF HIF1A IL6
6	growth/size/body region	MP:0005378	10.25	ACE EDN1 HGF HIF1A IL6 KDR
7	immune system	MP:0005387	10.2	ACE ANGPT2 CXCL12 HIF1A IL6 KDR
8	digestive/alimentary	MP:0005381	10.14	ANGPT2 EDN1 HIF1A IL6 NOS3 TNF
9	embryo	MP:0005380	10.13	EDN1 HGF HIF1A KDR PGF TEK
10	muscle	MP:0005369	10.11	CXCL12 EDN1 FGF2 HIF1A IL6 KDR
11	liver/biliary system	MP:0005370	10.09	ACE CXCL12 HGF HIF1A IL6 KDR
12	nervous system	MP:0003631	10	CXCL12 EDN1 FGF2 HIF1A IL6 KDR
13	neoplasm	MP:0002006	9.87	ACE FGF2 HIF1A IL6 PGF TNF
14	respiratory system	MP:0005388	9.81	ANGPT2 HIF1A IL6 KDR NOS3 PGF
15	skeleton	MP:0005390	9.56	EDN1 FGF2 HIF1A IL6 KDR NOS3
16	vision/eye	MP:0005391	9.32	ANGPT2 FGF2 HIF1A IL6 KDR NOS3

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Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 249)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Aspirin

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable

50-78-2

2244

Povidone

Approved

Phase 4

9003-39-8

Clindamycin

Approved, Vet_approved

Phase 4

18323-44-9

29029

Iodine

Approved, Investigational

Phase 4,Not Applicable

7553-56-2

807

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Teicoplanin

Approved, Investigational

Phase 4

61036-62-2

Chlorhexidine

Approved, Vet_approved

Phase 4

55-56-1

2713 9552079

Metronidazole

Approved

Phase 4

443-48-1

4173

Povidone-iodine

Approved

Phase 4

25655-41-8

Glucosamine

Approved, Investigational

Phase 4

3416-24-8

439213

Paclitaxel

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Not Applicable

33069-62-4

36314

Heparin

Approved, Investigational

Phase 4,Phase 1,Phase 2,Not Applicable

9005-49-6

772 46507594

Clopidogrel

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

113665-84-2, 120202-66-6

60606

Ticlopidine

Approved

Phase 4,Phase 3,Phase 2

55142-85-3

5472

Cilostazol

Approved, Investigational

Phase 4,Phase 3,Phase 2

73963-72-1

2754

Lenograstim

Approved, Investigational

Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1

135968-09-1

Alprostadil

Approved, Investigational

Phase 4,Phase 2

745-65-3

149351 5280723

Menthol

Approved

Phase 4

2216-51-5

16666

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 2

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 2

1177-87-3

Pentoxifylline

Approved, Investigational

Phase 4

6493-05-6

4740

Iloprost

Approved, Investigational

Phase 4

78919-13-8

6443959

Dalteparin

Approved

Phase 4,Phase 2

9005-49-6

Defibrotide

Approved, Investigational

Phase 4

83712-60-1

Ramipril

Approved

Phase 4

87333-19-5

5362129

Benzocaine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

94-09-7, 1994-09-7

2337

tannic acid

Approved

Phase 4,Phase 3,Phase 2,Phase 1

Zinc

Approved, Investigational

Phase 4,Phase 3

7440-66-6

Febuxostat

Approved

Phase 4

144060-53-7

134018

Esmolol

Approved

Phase 4

103598-03-4, 81147-92-4

59768

Pregabalin

Approved, Illicit, Investigational

Phase 4

148553-50-8

5486971

Insulin Glargine

Approved

Phase 4

160337-95-1

Phenylephrine

Approved

Phase 4

59-42-7

6041

Oxymetazoline

Approved, Investigational

Phase 4

1491-59-4

4636

Ephedrine

Approved

Phase 4

299-42-3

9294

Norepinephrine

Approved

Phase 4

51-41-2

439260

Pseudoephedrine

Approved

Phase 4

90-82-4

7028

Uric Acid

Experimental, Investigational

Phase 4

69-93-2

1175

Antibiotics, Antitubercular

Phase 4,Phase 2,Not Applicable

Antiparasitic Agents

Phase 4

penicillins

Phase 4

Clindamycin phosphate

Phase 4

Antitubercular Agents

Phase 4

Micronutrients

Phase 4,Not Applicable

Antiprotozoal Agents

Phase 4

Gentamicins

Phase 4

Anti-Infective Agents, Local

Phase 4,Not Applicable

Clindamycin palmitate

Phase 4

Anti-Bacterial Agents

Phase 4,Phase 2,Not Applicable

beta-Lactamase Inhibitors

Phase 4

Interventional clinical trials:

(show top 50) (show all 495)

#	Name	Status	NCT ID	Phase	Drugs
1	Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II)	Unknown status	NCT01173094	Phase 4
2	Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I)	Unknown status	NCT01171703	Phase 4
3	Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia	Unknown status	NCT02563535	Phase 4
4	Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix	Unknown status	NCT02279784	Phase 4
5	The Amputation Surgical Site Infection Trial (ASSIT)	Unknown status	NCT02018094	Phase 4	Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
6	Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery	Unknown status	NCT01147419	Phase 4
7	Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery	Unknown status	NCT02085551	Phase 4
8	Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND)	Completed	NCT00906022	Phase 4
9	Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia	Completed	NCT02369809	Phase 4	Neovasculgen®
10	Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation	Completed	NCT01558505	Phase 4
11	Cryoplasty CLIMB-registry	Completed	NCT00459888	Phase 4
12	Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE)	Completed	NCT00883246	Phase 4
13	Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV	Completed	NCT00596752	Phase 4	Alprostadil
14	DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions	Completed	NCT00637741	Phase 4
15	Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp)	Completed	NCT00300690	Phase 4
16	Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions	Completed	NCT00764777	Phase 4
17	NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions	Completed	NCT01783600	Phase 4
18	Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans	Completed	NCT02117206	Phase 4	L-arginine (L-arginine Veyron);Nacl
19	Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease	Completed	NCT01983449	Phase 4	Dexamethasone Sodium Phosphate Injection, USP
20	AngioSeal Versus Radial Approach in Acute Coronary Syndrome	Completed	NCT01653587	Phase 4
21	Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery	Completed	NCT01427621	Phase 4
22	Instrumental Sealing of Arterial Puncture Site Closure Device Versus Manual Compression Trial	Completed	NCT01389375	Phase 4
23	Peripheral Vascular Disease and Nerve Stimulation	Completed	NCT01942941	Phase 4
24	Optimization of Treatment in Patients With Severe Peripheral Ischemia (Fontaine Stage IIb)	Completed	NCT01718288	Phase 4	iloprost;Standard Treatment (aspirin.....),
25	Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants	Completed	NCT01037530	Phase 4	Ramipril
26	The Study to Compare SMART Nitinol Stent and Balloon Angioplasty	Completed	NCT00309595	Phase 4
27	The Study to Compare the Cordis SMART™ Stent System With the Bard® Luminexx™ Stent	Completed	NCT00235131	Phase 4
28	DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions	Completed	NCT01412463	Phase 4
29	Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study)	Recruiting	NCT02829151	Phase 4	Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
30	Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging	Recruiting	NCT02807779	Phase 4	Dexamethasone infusion
31	Lowering-hyperuricemia Treatment on Cardiovascular Outcomes in Peritoneal Dialysis Patients	Recruiting	NCT03200210	Phase 4	Febuxostat;Placebo
32	Vascular Closure Device Versus Transradial Approach in Primary Percutaneous Coronary Intervention	Recruiting	NCT02831166	Phase 4
33	Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE)	Recruiting	NCT03549923	Phase 4	Esmolol;Standard care
34	The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial	Recruiting	NCT03668236	Phase 4	Isotonic crystalloids
35	Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia	Terminated	NCT00403780	Phase 4	pregabalin;placebo
36	Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia	Terminated	NCT00504088	Phase 4
37	Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty	Terminated	NCT01150617	Phase 4	Insulin glargine plus insulin analogues
38	Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients	Terminated	NCT02203630	Phase 4	Phenylephrine;Norepinephrine
39	AGIR Study: Angio-Seal in Interventional Radiology	Terminated	NCT01911403	Phase 4
40	Use Art-assist and Neupogen to Treat Chronic Limb Ischemia	Withdrawn	NCT02408991	Phase 4	Neupogen
41	Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia	Unknown status	NCT00539266	Phase 2, Phase 3
42	VADOplex Critical Limb Ischemia Study	Unknown status	NCT02034539	Phase 2, Phase 3
43	Distal Venous Arterialisation of Ischemic Limb	Unknown status	NCT01211925	Phase 2, Phase 3	Aspirin
44	Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia	Unknown status	NCT00434616	Phase 2, Phase 3
45	Pain and Music Therapy in Patients Suffering Arteritis	Unknown status	NCT01323504	Phase 3
46	Effects of Prolonged DAPT After Lower Extremity Percutaneous Transluminal Angioplasty (PTA) in Patients With LE-PAD	Unknown status	NCT02798913	Phase 3	Short DAPT;Long DAPT
47	Transfusion Requirements in Critically Ill Oncologic Patient	Unknown status	NCT01648946	Phase 3
48	NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study	Unknown status	NCT00358085	Phase 3
49	Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI	Unknown status	NCT03001960	Phase 3	Preloading before TAVI;Postloading after TAVI
50	Claudication: Exercise Versus Endoluminal Revascularization (CLEVER)	Unknown status	NCT00132743	Phase 3	Cilostazol

Search NIH Clinical Center for Limb Ischemia

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Genetic Tests for Limb Ischemia

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Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

⁴¹

Bone, Bone Marrow, Endothelial, Heart, Kidney, Lung, Liver

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Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 1579)

#	Title	Authors	Year
1	Human primary CD34<sup>+</sup> cells transplantation for critical limb ischemia. ( 29893031 )	Lian W....Li M.	2018
2	Acute Limb Ischemia Secondary to Native Artery Occlusion: Results of a Contemporary Case Series. ( 29404750 )	SeguA- N....ClarA! A.	2018
3	Efficacy Outcomes of Endovascular Versus Surgical Revascularization in Critical Limb Ischemia: Results From a Prospective Cohort Study. ( 29355026 )	Schindewolf M....Baumgartner I.	2018
4	Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. ( 29373539 )	Simon F....Duran M.	2018
5	Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion. ( 29960153 )	Hsieh K.F....Yeh S.L.	2018
6	Lower limb ischemia due to popliteal artery compression by Baker cyst. ( 29942891 )	Fujiyoshi K....Ako J.	2018
7	Lower extremity bypass and endovascular intervention for critical limb ischemia fail to meet Society for Vascular Surgery's objective performance goals for limb-related outcomes in a contemporary national cohort. ( 29937289 )	Robinson W.P....Upchurch G.R.	2018
8	Rationale and design of the SAIL trial for intramuscular injection of allogeneic mesenchymal stromal cells in no-option critical limb ischemia. ( 29242062 )	Wijnand J.G.J....Verhaar M.C.	2018
9	Natural language processing of clinical notes for identification of critical limb ischemia. ( 29425639 )	Afzal N....Arruda-Olson A.M.	2018
10	Spinal Cord Stimulation Improves the Microvascular Perfusion Insufficiency Caused by Critical Limb Ischemia. ( 29377343 )	Liu J.T....Chang C.S.	2018
11	Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia. ( 29796803 )	Lykov A.P....Poveshchenko A.F.	2018
12	Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan. ( 29386474 )	Kondo K....Matoba S.	2018
13	Acute limb ischemia of the lower extremity associated with left upper lobe surgery for primary lung cancer. ( 29942889 )	Inoue S....Okabayashi K.	2018
14	Simultaneous Hybrid Operation Common Femoral Endarterectomy and Endovascular Treatment in Multilevel Peripheral Arterial Disease with Critical Limb Ischemia. ( 29915480 )	Jung H.J....Lee S.S.	2018
15	Clinical significance of perioperative changes in ankle-brachial index with regard to extremity-related outcome in non-diabetic patients with critical limb ischemia. ( 29911291 )	Bischoff M.S....BAPckler D.	2018
16	Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia. ( 29395424 )	Wang S.K....Murphy M.P.	2018
17	The Role of miR-126 in Critical Limb Ischemia Treatment Using Adipose-Derived Stem Cell Therapeutic Factor Concentrate and Extracellular Matrix Microparticles. ( 29371587 )	ProchA!zka V....Johnstone B.H.	2018
18	MicroRNA-19 restores vascular endothelial cell function in lower limb ischemia-reperfusion injury through the KLF10-dependent TGF-I^1/Smad signaling pathway in rats. ( 29953651 )	Xu Y.L....Wu Y.	2018
19	Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty. ( 29860903 )	Nemcova A....Jude E.B.	2018
20	Pathophysiology of chronic limb ischemia. ( 29950791 )	Simon F....Duran M.	2018
21	Efficacy of regional saturation of oxygen monitor using near-infrared spectroscopy for lower limb ischemia during minimally invasive cardiac surgery. ( 29938392 )	Toya T....Kobayashi J.	2018
22	One-Year Results of First-Line Treatment Strategies in Patients With Critical Limb Ischemia (CRITISCH Registry). ( 29968501 )	Stavroulakis K....Bisdas T.	2018
23	The Incidence, Risk Factors, and Outcomes of Contrast-Induced Nephropathy In Patients With Critical Limb Ischemia Following Lower Limb Angiography. ( 29390867 )	Cury M.V.M....Sacilotto R.	2018
24	Impact of infection severity on clinical outcomes in critical limb ischemia with tissue loss after endovascular treatment. ( 29967952 )		2018
25	Field testing for the critical limb ischemia cost measure. ( 29801561 )		2018
26	Outcomes of Duplex guided paramalleolar and inframalleolar bypass in patients with critical limb ischemia. ( 29886216 )		2018
27	miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia. ( 29908843 )		2018
28	Mycotic Renal Artery Aneurysm Presenting as Critical Limb Ischemia in Culture-Negative Endocarditis. ( 29854544 )		2018
29	Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials. ( 29977308 )		2018
30	Reinterventions following endovascular revascularization in elderly with critical limb ischemia; an observational study. ( 29886205 )		2018
31	Clinical Outcomes after Isolated Infrapopliteal Revascularization in Hemodialysis Patients with Critical Limb Ischemia: Endovascular Therapy versus Bypass Surgery. ( 29367521 )		2018
32	Disease Burden and Clinical Outcomes Following Initial Diagnosis of Critical Limb Ischemia in the Medicare Population. ( 29798766 )		2018
33	BAD transmission and SAD distribution: a new scenario for critical limb ischemia. ( 29786411 )		2018
34	The influence of patients' nutritional status on the prevalence, course and treatment outcomes of lower limb ischemia: an overview of current evidence. ( 29385791 )		2018
35	Predictive factors of a poor outcome following revascularization for critical limb ischemia: implications for practice. ( 29792018 )		2018
36	Noninvasive measurements of tissue perfusion in critical limb ischemia. ( 29950790 )		2018
37	Assessment of Tissue Perfusion with Blood Oxygenation Level-Dependent Magnetic Resonance Imaging in Critical Limb Ischemia. ( 29968440 )		2018
38	Design Strategies for Global Clinical Trials of Endovascular Devices for Critical Limb Ischemia (CLI)a88- A Joint USA-Japanese Perspective. ( 29962385 )		2018
39	Successful Simultaneous Revascularization for Acute Limb Ischemia and Concomitant Acute Myocardial Infarction. ( 30402191 )	Miyake K...Azuma N	2018
40	An Unusual Case of Acute Thrombosis of Abdominal Aortic Aneurysm without Acute Limb Ischemia. ( 30079935 )	Vasdekis SN...Moulakakis KG	2018
41	Outcomes in Patients with Critical Limb Ischemia due to Arteriosclerosis Obliterans Who Did Not Undergo Arterial Reconstruction. ( 30101855 )	Akagi D...Yamamoto K	2018
42	Length and Cost of Hospital Stay in Poor-Risk Patients With Critical Limb Ischemia Undergoing Revascularization. ( 30012928 )	Takahara M...PRIORITY Investigators	2018
43	Percutaneous Deep Venous Arterialization for Severe Critical Limb Ischemia in Patients With No Option of Revascularization: Early Experience From Two European Centers. ( 30019194 )	Del Giudice C...Sapoval M	2018
44	Open Versus Endovascular Revascularization of Below-Knee Arteries in Patients With End-Stage Renal Disease and Critical Limb Ischemia. ( 30021493 )	Meyer A...Regus S	2018
45	Autologous Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood CD34 Positive Cell Transplantation for Hemodialysis Patients with Critical Limb Ischemia: A Prospective Phase II Clinical Trial. ( 30059194 )	Ohtake T...Kobayashi S	2018
46	Treatment of Nonreconstructable Critical Limb Ischemia With Ischemic Wounds Utilizing a Noninvasive Intermittent Pneumatic Compression Device Monitored With Fluorescence Angiography. ( 30059338 )	Andersen CA...Marmolejo V	2018
47	Correction to: Percutaneous Deep Venous Arterialization for Severe Critical Limb Ischemia in Patients With No Option of Revascularization: Early Experience From Two European Centers. ( 30062443 )	Del Giudice C...Sapoval M	2018
48	Comparison of the Cost of Drug-Eluting Stents versus Bare Metal Stents in the Treatment of Critical Limb Ischemia in the United States. ( 30092444 )	Locham SS...Malas MB	2018
49	Contemporary Management of Critical Limb Ischemia. ( 30098617 )	Thompson JR...Henke PK	2018
50	Evaluation of the BASIL Survival Prediction Model in Patients Undergoing Infrapopliteal Interventions for Critical Limb Ischemia. ( 30099169 )	Cury MVM...Sacilotto R	2018

Sources

Genes for Limb Ischemia

Genes related to Limb Ischemia (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	23.82	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	NOS3	Nitric Oxide Synthase 3	Protein Coding	23.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	FGF2	Fibroblast Growth Factor 2	Protein Coding	23.03	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	HGF	Hepatocyte Growth Factor	Protein Coding	22.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	KDR	Kinase Insert Domain Receptor	Protein Coding	22.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL6	Interleukin 6	Protein Coding	22.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	22.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	21.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	VWF	Von Willebrand Factor	Protein Coding	21.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	PGF	Placental Growth Factor	Protein Coding	21.4	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	21.31	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	ACE	Angiotensin I Converting Enzyme	Protein Coding	21.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	TNF	Tumor Necrosis Factor	Protein Coding	21.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	EDN1	Endothelin 1	Protein Coding	20.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	TNNI3	Troponin I3, Cardiac Type	Protein Coding	20.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	ANGPT2	Angiopoietin 2	Protein Coding	20.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Limb Ischemia

Sources

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Sources

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 65)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁶ Show member pathways GPCR downstream signaling ⁶⁶ Signal Transduction ⁶⁶	14.17	CXCL12 EDN1 FGF2 HGF HIF1A IL6
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.86	ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.72	CXCL12 FGF2 HGF IL6 KDR NOS3
4	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.68	ANGPT2 CXCL12 EDN1 HGF IL6 KDR
5	Activation of cAMP-Dependent PKA ⁶⁴ Show member pathways Activation of PKA through GPCR ⁶⁴ cAMP Pathway ⁶⁴ PKA Signaling ⁶⁴	13.58	CXCL12 FGF2 HGF IL6 KDR NOS3
6	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.55	ANGPT2 CXCL12 FGF2 HGF IL6 KDR
7	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.48	FGF2 HGF KDR TEK TNF VEGFA
8	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.38	FGF2 HGF HIF1A IL6 TEK TNF
9	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.37	ANGPT2 CXCL12 FGF2 HGF IL6 KDR
10	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	13.34	CXCL12 FGF2 HGF IL6 KDR PGF
11	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.32	ANGPT2 CXCL12 FGF2 HGF IL6 KDR
12	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	13.29	ANGPT2 HGF NOS3 TEK VEGFA VWF
13	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.21	CXCL12 FGF2 HGF IL6 KDR NOS3
14	Human cytomegalovirus infection ³⁷ Show member pathways Hepatitis B ³⁷ Human immunodeficiency virus 1 infection ³⁷ Kaposi sarcoma-associated herpesvirus infection ³⁷	13.09	ANGPT2 CXCL12 FGF2 HIF1A IL6 TNF
15	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13.08	CXCL12 FGF2 HGF IL6 KDR PGF
16	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	13.08	ACE CXCL12 FGF2 HGF HIF1A IL6
17	Focal Adhesion ¹ ³⁷ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.89	HGF KDR PGF VEGFA VWF
18	Pathways in cancer ³⁷	12.89	CXCL12 FGF2 HGF HIF1A IL6 PGF
19	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.79	FGF2 HGF IL6 KDR VEGFA
20	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.77	ANGPT2 FGF2 HGF KDR PGF TEK
21	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.74	ANGPT2 FGF2 HGF IL6 KDR NOS3
22	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.73	CXCL12 FGF2 HGF IL6 KDR PGF
23	MAPK signaling pathway ³⁷ ¹	12.67	ANGPT2 FGF2 HGF KDR PGF TEK
24	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.65	ANGPT2 FGF2 IL6 NOS3 TEK TNF
25	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁷ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁷	12.57	KDR NOS3 TNF VEGFA
26	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ¹	12.45	CXCL12 FGF2 HGF IL6 KDR PGF
27	VEGF Pathway (Qiagen) ²² Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴ VEGF Pathway ⁶⁴	12.4	KDR NOS3 PGF VEGFA
28	Proteoglycans in cancer ³⁷	12.32	FGF2 HGF HIF1A KDR TNF VEGFA
29	VEGF Signaling Pathway ⁶¹ ⁶⁷ Show member pathways Nanoparticle-mediated activation of receptor signaling ¹ TGF-beta Signaling ⁶⁷	12.25	FGF2 KDR NOS3 VEGFA
30	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.25	CXCL12 FGF2 HGF IL6 KDR PGF
31	Dilated cardiomyopathy (DCM) ³⁷ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁷	12.24	ACE IL6 TNF TNNI3
32	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.21	HIF1A IL6 TNF VEGFA
33	Fluid shear stress and atherosclerosis ³⁷	12.17	EDN1 KDR NOS3 TNF VEGFA
34	Tyrosine Kinases / Adaptors ⁴	12.16	ANGPT2 FGF2 KDR TEK
35	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.07	ANGPT2 CXCL12 FGF2 HGF IL6 KDR
36	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12.03	FGF2 HGF IL6 KDR TNNI3 VEGFA
37	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.97	EDN1 IL6 NOS3 TNF VEGFA
38	TNF signaling pathway ³⁷	11.95	EDN1 IL6 TNF
39	Insulin resistance ³⁷ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.94	IL6 NOS3 TNF
40	Signaling events mediated by VEGFR1 and VEGFR2 ¹ Show member pathways VEGFR1 specific signals ¹	11.92	HIF1A KDR NOS3 PGF VEGFA
41	Rheumatoid arthritis ³⁷	11.9	CXCL12 IL6 TEK TNF VEGFA
42	Interleukin-4 and 13 signaling ⁶⁶	11.9	FGF2 HGF HIF1A IL6 TNF VEGFA
43	HIF-1 signaling pathway ³⁷	11.8	ANGPT2 EDN1 HIF1A IL6 NOS3 TEK
44	G-protein signaling_RhoA regulation pathway ²²	11.77	CXCL12 FGF2 HGF IL6 PGF
45	HIF-1-alpha transcription factor network ¹	11.76	CXCL12 EDN1 HIF1A VEGFA
46	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.7	IL6 TNF VEGFA
47	HIF1Alpha Pathway ⁶⁴	11.67	EDN1 HIF1A NOS3 VEGFA
48	Lung fibrosis ¹	11.67	EDN1 FGF2 HGF IL6 TNF
49	Cardiac Progenitor Differentiation ¹	11.62	FGF2 KDR TNNI3
50	Differentiation Pathway ¹	11.62	FGF2 HGF IL6 VEGFA

Sources

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.65	ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2	extracellular region	GO:0005576	9.44	ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
3	platelet alpha granule lumen	GO:0031093	9.43	HGF VEGFA VWF
4	Weibel-Palade body	GO:0033093	9.16	EDN1 VWF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 64)

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyl-tyrosine phosphorylation	GO:0018108	9.97	FGF2 HGF KDR TEK
2	positive regulation of cell migration	GO:0030335	9.97	CXCL12 EDN1 HGF KDR VEGFA
3	regulation of signaling receptor activity	GO:0010469	9.97	CXCL12 EDN1 FGF2 HGF IL6 PGF
4	positive regulation of protein kinase B signaling	GO:0051897	9.96	FGF2 HGF TEK TNF
5	cytokine-mediated signaling pathway	GO:0019221	9.93	FGF2 HGF HIF1A IL6 TNF VEGFA
6	activation of MAPK activity	GO:0000187	9.91	FGF2 HGF TNF
7	negative regulation of gene expression	GO:0010629	9.91	ACE EDN1 HIF1A KDR TNF VEGFA
8	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.9	EDN1 IL6 TNF
9	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.9	HGF IL6 VEGFA
10	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.89	IL6 TNF VEGFA
11	regulation of blood pressure	GO:0008217	9.88	ACE EDN1 NOS3
12	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.88	KDR PGF VEGFA
13	positive regulation of protein phosphorylation	GO:0001934	9.88	HGF KDR PGF TEK TNF VEGFA
14	vasculogenesis	GO:0001570	9.87	KDR TNNI3 VEGFA
15	positive regulation of smooth muscle cell proliferation	GO:0048661	9.86	EDN1 IL6 TNF
16	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.86	HGF KDR TEK TNF
17	positive regulation of cell adhesion	GO:0045785	9.85	CXCL12 TNF VEGFA
18	positive regulation of vascular smooth muscle cell proliferation	GO:1904707	9.84	EDN1 FGF2 TNF
19	positive regulation of cell division	GO:0051781	9.84	FGF2 PGF VEGFA
20	positive regulation of MAP kinase activity	GO:0043406	9.84	EDN1 FGF2 TNF VEGFA
21	positive regulation of endothelial cell migration	GO:0010595	9.83	EDN1 KDR TEK VEGFA
22	positive regulation of cell migration involved in sprouting angiogenesis	GO:0090050	9.82	FGF2 KDR VEGFA
23	sprouting angiogenesis	GO:0002040	9.8	PGF TEK VEGFA
24	positive chemotaxis	GO:0050918	9.8	FGF2 HGF PGF VEGFA
25	response to hypoxia	GO:0001666	9.8	ANGPT2 CXCL12 EDN1 HIF1A PGF TEK
26	blood vessel morphogenesis	GO:0048514	9.79	ANGPT2 EDN1 HIF1A
27	animal organ regeneration	GO:0031100	9.78	ANGPT2 CXCL12 HGF PGF
28	positive regulation of focal adhesion assembly	GO:0051894	9.77	KDR TEK VEGFA
29	cell migration involved in sprouting angiogenesis	GO:0002042	9.77	FGF2 KDR VEGFA
30	positive regulation of chemokine production	GO:0032722	9.76	HIF1A IL6 TNF
31	angiogenesis	GO:0001525	9.76	ANGPT2 FGF2 HIF1A KDR NOS3 PGF
32	vascular endothelial growth factor signaling pathway	GO:0038084	9.74	KDR PGF VEGFA
33	positive regulation of glial cell proliferation	GO:0060252	9.73	IL6 TNF
34	embryonic hemopoiesis	GO:0035162	9.73	HIF1A KDR
35	heart contraction	GO:0060047	9.73	ACE TNNI3
36	positive regulation of DNA biosynthetic process	GO:2000573	9.73	FGF2 HGF
37	positive regulation of positive chemotaxis	GO:0050927	9.72	KDR VEGFA
38	negative regulation of lipid storage	GO:0010888	9.72	IL6 TNF
39	induction of positive chemotaxis	GO:0050930	9.72	CXCL12 PGF VEGFA
40	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.72	FGF2 HIF1A KDR NOS3 VEGFA
41	neutrophil mediated immunity	GO:0002446	9.71	ACE IL6
42	positive regulation of axon extension involved in axon guidance	GO:0048842	9.71	CXCL12 VEGFA
43	positive regulation of receptor biosynthetic process	GO:0010870	9.71	EDN1 HIF1A
44	positive regulation of mast cell chemotaxis	GO:0060754	9.69	PGF VEGFA
45	positive regulation of neuroinflammatory response	GO:0150078	9.69	IL6 TNF
46	regulation of systemic arterial blood pressure by endothelin	GO:0003100	9.69	EDN1 NOS3
47	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	GO:0038033	9.68	KDR VEGFA
48	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061419	9.68	HIF1A VEGFA
49	glomerulus vasculature development	GO:0072012	9.65	ANGPT2 TEK
50	positive regulation of peptidyl-tyrosine autophosphorylation	GO:1900086	9.65	ACE VEGFA

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:0004713	9.62	FGF2 HGF KDR TEK
2	Ras guanyl-nucleotide exchange factor activity	GO:0005088	9.61	FGF2 HGF TEK
3	integrin binding	GO:0005178	9.56	CXCL12 FGF2 KDR VWF
4	chemoattractant activity	GO:0042056	9.46	FGF2 HGF PGF VEGFA
5	cytokine activity	GO:0005125	9.43	CXCL12 EDN1 FGF2 IL6 TNF VEGFA
6	vascular endothelial growth factor receptor 3 binding	GO:0043185	9.4	PGF VEGFA
7	growth factor activity	GO:0008083	9.1	CXCL12 FGF2 HGF IL6 PGF VEGFA
8	protein binding	GO:0005515	10.24	ANGPT2 CXCL12 EDN1 FGF2 HGF HIF1A

Sources

Sources for Limb Ischemia

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⁷¹ TGDB

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⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia