MCID: LMB062
MIFTS: 55

Limb Ischemia

Categories: Cardiovascular diseases

Aliases & Classifications for Limb Ischemia

MalaCards integrated aliases for Limb Ischemia:

Name: Limb Ischemia 12 15 37 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050852
UMLS 71 C2945695

Summaries for Limb Ischemia

Disease Ontology : 12 An ischemia that is characterized by low blood supply to tissues in the limb due to interruption in the arterial blood supply.

MalaCards based summary : Limb Ischemia is related to peripheral vascular disease and ischemia. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are cardiovascular system and cellular

Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 623)
# Related Disease Score Top Affiliating Genes
1 peripheral vascular disease 31.6 VWF VEGFA SELE NOS3 IL6 CCL2
2 ischemia 31.6 VEGFA TEK NOS3 MIR21 KDR HIF1A
3 buerger disease 31.6 SELE NOS3 HGF
4 arteriosclerosis obliterans 31.5 MIR21 IL6 HGF
5 end stage renal disease 31.4 VEGFA TNF NOS3 IL6 ACE
6 aortic aneurysm 31.0 MMP9 MIR21 IL6 ACE
7 vasculitis 31.0 VWF TNF SELE IL6 CCL2
8 aortic aneurysm, familial abdominal, 1 30.9 MMP9 IL6 CCL2 ACE
9 polyarteritis nodosa 30.9 SELE IL6 FGF2
10 osteomyelitis 30.8 TNF IL6 CCL2
11 peripheral artery disease 30.8 VWF VEGFA TNF NOS3 IL6 HIF1A
12 arteries, anomalies of 30.7 VWF VEGFA TNF NOS3 MIR21 IL6
13 intermittent claudication 30.7 VWF VEGFA TEK PGF IL6 FGF2
14 congestive heart failure 30.7 VEGFA TNF NOS3 IL6 ANGPT2 ACE
15 antiphospholipid syndrome 30.7 VWF TNF SELE PGF
16 lipid metabolism disorder 30.7 SELE MIR21 IL6 CCL2 ACE
17 pulmonary edema 30.6 TNF TEK NOS3 HIF1A ACE
18 angina pectoris 30.6 NOS3 IL6 ACE
19 purpura 30.5 VWF TNF IL6 ACE
20 systemic scleroderma 30.5 TNF SELE MIR21 IL6 ACE
21 homocysteinemia 30.5 VWF NOS3 CCL2
22 atrial fibrillation 30.5 VWF NOS3 MIR21 IL6 ACE
23 proteasome-associated autoinflammatory syndrome 1 30.5 TNF SELE MMP9 IL6 CCL2
24 chronic ulcer of skin 30.4 VEGFA TNF MMP9 IL6 FGF2
25 cerebrovascular disease 30.4 VWF TNF SELE MMP9 MIR21 IL6
26 essential thrombocythemia 30.4 VWF VEGFA TNF IL6 FGF2
27 uremia 30.4 VWF TNF IL6 ACE
28 plague 30.4 TNF SELE IL6
29 coronary heart disease 1 30.4 VWF SELE NOS3 IL6 ACE
30 peripartum cardiomyopathy 30.4 VEGFA PGF MIR21 ACE
31 hyperglycemia 30.3 SELE NOS3 IL6 HIF1A
32 infective endocarditis 30.3 TNF SIGLEC5 IL6
33 intermediate coronary syndrome 30.3 VWF IL6 ACE
34 diabetic angiopathy 30.3 VWF SELE NOS3 CCL2
35 disseminated intravascular coagulation 30.3 VWF TNF SELE IL6
36 chronic kidney disease 30.2 VEGFA TNF NOS3 MMP9 IL6 HGF
37 connective tissue disease 30.2 VEGFA TNF MIR21 IL6 ACE
38 exanthem 30.2 VEGFA TNF KDR IL6 ACE
39 acute cystitis 30.2 TNF IL6 CCL2 ACE
40 placenta disease 30.2 VEGFA TNF PGF IL6
41 severe acute respiratory syndrome 30.2 TNF IL6 CCL2 ACE
42 sarcoma 30.2 VEGFA KDR IL6 HIF1A FGF2 ANGPT2
43 myocarditis 30.2 TNF IL6 CCL2 ACE
44 pyoderma 30.2 TNF SIGLEC5 MMP9
45 pyoderma gangrenosum 30.2 TNF SIGLEC5 MMP9
46 blood coagulation disease 30.1 VWF VEGFA TNF SIGLEC5 IL6
47 carpal tunnel syndrome 30.1 VEGFA IL6 FGF2 CCL2 ACE
48 deficiency anemia 30.1 TNF IL6 HIF1A ACE
49 pneumonia 30.1 TNF MMP9 IL6 CCL2 ACE
50 atherosclerosis susceptibility 30.1 VWF VEGFA TNF SELE NOS3 MMP9

Graphical network of the top 20 diseases related to Limb Ischemia:



Diseases related to Limb Ischemia

Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 ACE ANGPT2 CXCL12 FGF2 HGF HIF1A
2 cellular MP:0005384 10.34 ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3 hematopoietic system MP:0005397 10.34 ACE CXCL12 FGF2 HGF HIF1A IL6
4 homeostasis/metabolism MP:0005376 10.32 ACE ANGPT2 FGF2 HIF1A IL6 KDR
5 immune system MP:0005387 10.3 ACE ANGPT2 CCL2 CXCL12 HIF1A IL6
6 mortality/aging MP:0010768 10.24 ACE ANGPT2 CXCL12 FGF2 HGF HIF1A
7 digestive/alimentary MP:0005381 10.11 ANGPT2 HIF1A IL6 MMP9 NOS3 TNF
8 liver/biliary system MP:0005370 10.1 ACE CXCL12 HGF HIF1A IL6 KDR
9 integument MP:0010771 10.09 ANGPT2 HIF1A IL6 KDR MMP9 PGF
10 muscle MP:0005369 10.02 CXCL12 FGF2 HIF1A IL6 KDR MMP9
11 nervous system MP:0003631 9.9 CXCL12 FGF2 HIF1A IL6 KDR MMP9
12 neoplasm MP:0002006 9.86 ACE FGF2 HIF1A IL6 MMP9 PGF
13 respiratory system MP:0005388 9.65 ANGPT2 HIF1A IL6 KDR MMP9 NOS3
14 vision/eye MP:0005391 9.4 ANGPT2 FGF2 HIF1A IL6 KDR MMP9

Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 214)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
4
Simvastatin Approved Phase 4 79902-63-9 54454
5
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
6
Evolocumab Approved Phase 4 1256937-27-5
7
Liraglutide Approved Phase 4 204656-20-2 44147092
8
Glucagon Approved Phase 4 16941-32-5
9
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
10
carbamide peroxide Approved Phase 4 124-43-6
11
Apixaban Approved Phase 4 503612-47-3 10182969
12
Rivaroxaban Approved Phase 4 366789-02-8
13
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
14
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
15
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
16
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
17
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
18
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
19
Ticagrelor Approved Phase 4 274693-27-5 9871419
20
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
21
tannic acid Approved Phase 4 1401-55-4
22
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
23
Metformin Approved Phase 4 657-24-9 14219 4091
24
Adenosine Approved, Investigational Phase 4 58-61-7 60961
25
Zinc Approved, Investigational Phase 4 7440-66-6 32051
26
Insulin glargine Approved Phase 4 160337-95-1
27
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
28
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
29 Blood Substitutes Phase 4
30 Gastrointestinal Agents Phase 4
31 Antineoplastic Agents, Hormonal Phase 4
32 Antiemetics Phase 4
33 Dexamethasone 21-phosphate Phase 4
34 glucocorticoids Phase 4
35 BB 1101 Phase 4
36 Vitamins Phase 4
37 Micronutrients Phase 4
38 Trace Elements Phase 4
39 Nutrients Phase 4
40 Vitamin B Complex Phase 4
41 Nicotinic Acids Phase 4
42 Vitamin B3 Phase 4
43 Folate Phase 4
44 Vitamin B9 Phase 4
45 Pharmaceutical Solutions Phase 4
46 Hormone Antagonists Phase 4
47 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
48 Hypolipidemic Agents Phase 4
49 Lipid Regulating Agents Phase 4
50 Anticholesteremic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 518)
# Name Status NCT ID Phase Drugs
1 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia: A Multi-center, Randomized Controlled Trial and Registration Study(Part I) Unknown status NCT01171703 Phase 4
2 DCLI-II:Optimized Strategy for Diabetic Patients With Critical Limb Ischemia: A Multi-center, Randomized Controlled Trial and Registration Study(Part II) Unknown status NCT01173094 Phase 4
3 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
4 The Study to Compare the Treatment of Stent and Prothesis Bypass in SFA Occlusions Unknown status NCT01147419 Phase 4
5 The Cook Zilver PTX Drug-eluting Stent Versus Bypass Surgery for the Treatment The Cook Zilver PTX Drug-eluting Stent Versus Bypass Surgery of Femoropopliteal TASC C&D Lesions Unknown status NCT01952457 Phase 4
6 The Effect of Far Infrared (FIR) Therapy on Access Flow of Arteriovenous (AV) Fistula, Echocardiographic Parameters and Endothelial Function in Patients With End Stage Renal Disease Unknown status NCT01138254 Phase 4
7 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation: the DEBATE-BTK Study Completed NCT01558505 Phase 4
8 CLIMB Prospective Multicenter Registry Evaluating the Use of the PolarCath Peripheral Dilatation System (Boston Scientific) in the Treatment of Infrapopliteal Lesions in Patients With Critical Limb Ischemia (Rutherford 4 and 5). Completed NCT00459888 Phase 4
9 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Completed NCT02563535 Phase 4
10 EXPAND Study - Self Expanding Nitinol Stent Versus PTA With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication. A Prospective, Multi-center, Randomized Clinical Trail With Follow-up Investigations at 1, 3, 6, and 12 Months. Completed NCT00906022 Phase 4
11 International Postmarketing Surveillance Study of Pl-VEGF165 Safety and Efficacy in 210 Patients With Peripheral Arterial Disease Completed NCT02369809 Phase 4 Neovasculgen®
12 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
13 Physician Initiated Multi-center Belgian-Italian-Dutch Trial Investigating Abbott Vascular Iliac Stents in the Treatment of TASC A, B, C & D Iliac Lesions Completed NCT00764777 Phase 4
14 Multinational, Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel Groups Study to Assess the Efficacy and Safety of Prostaglandin E1 in Subjects With Critical Limb Ischemia (Fontaine Stage IV) Completed NCT00596752 Phase 4 Alprostadil
15 Physician Initiated Trial Investigating the Efficacy of the Implant of EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
16 Delivery of Dexamethasone to the Adventitia to eNhance Clinical Efficacy After Femoropopliteal Revascularization Completed NCT01983449 Phase 4 Dexamethasone Sodium Phosphate Injection, USP
17 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
18 Balloon Angioplasty Versus Stenting With Nitinol Stents in the Superficial Femoral Artery Completed NCT00281060 Phase 4
19 Strategy for Managing Antiplatelet Therapy in the Perioperative Period of Non Coronary Surgery Completed NCT00190307 Phase 4 aspirin 75 mg/day
20 Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans Completed NCT02117206 Phase 4 L-arginine (L-arginine Veyron);Nacl
21 Magnetic Resonance Characterization of Carotid Atherosclerotic Plaque in Vivo: Effect of High Density Lipoprotein Elevation on Plaque Morphology Completed NCT00307307 Phase 4 Niacin/simvastatin compared to simvastatin alone at 2 doses
22 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Recruiting NCT02829151 Phase 4 Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
23 Effect of Evolocumab in Patients With Critical Limb Ischemia Recruiting NCT04306471 Phase 4 Evolocumab 140mg/mL Injector 1milliliter (mL) Pen x 3 for a monthly dose of 420 mg for 12 months.
24 Impact of Intravenous Iron Treatment of Preoperative Anemia in Patients With Lower Extremity Peripheral Artery Disease Recruiting NCT04083755 Phase 4 Ferric Carboxymaltose Injection [Injectafer]
25 Liraglutide Efficacy and Action on Type 2 Diabetes With Peripheral Atherosclerotic intErmittent Claudication (LEADPACE STUDY): a Prospective, 24-week, Multicenter, Randomized, Controlled Clinical Study Recruiting NCT04146155 Phase 4 Liraglutide+standard-of-care treatment
26 Impact of Early CRRT Intervention in Patients Receiving VA-ECMO Support on 30-day Mortality: A Randomized Controlled Trial Recruiting NCT03549923 Phase 4 Esmolol;Standard care
27 Efficacy of Alprostadil as an Adjuvant Therapy With Indirect Angiosomal Revascularization in Patients With Critical Limb Ischemia. Not yet recruiting NCT04312555 Phase 4 Alprostadil
28 DUAL Pathway Inhibition (Low-dose Rivaroxaban and Aspirin) as Compared to Aspirin Only to Improve Endothelial Function in Peripheral Artery Disease. Not yet recruiting NCT04218656 Phase 4 Rivaroxaban 2.5 Mg Oral Tablet
29 High Dose Intravenous Lidocaine vs Hydromorphone for Acute Abdominal Pain in the Emergency Department: A Randomized, Comparative Efficacy Trial Not yet recruiting NCT04398316 Phase 4 Lidocaine Iv;HYDROmorphone Injection
30 Randomized Controlled Trial of Extended-Duration Low-Dose Apixaban to Prevent Recurrence in High-Risk Patients With Provoked Venous Thromboembolism Not yet recruiting NCT04168203 Phase 4 Apixaban 2.5 MG;Placebo oral tablet
31 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
32 Pregabalin for Pain Reduction in Critical Limb Ischemia - A Double Blind, Randomized Controlled Study Terminated NCT00403780 Phase 4 pregabalin;placebo
33 Balloon Angioplasty vs. Cutting Balloon Angioplasty of Femoropopliteal Arteries- a Randomized Controlled Trial Terminated NCT00437905 Phase 4
34 Cilostazol After Lower Extremity Arterial Revascularization Trial (CLEAR) Terminated NCT02374957 Phase 4 Cilostazol
35 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Terminated NCT01901224 Phase 4 Metformin 1000 mg;Placebo
36 Impact of Ticagrelor and Aspirin Versus Clopidogrel and Aspirin in Patients With Claudication and Peripheral Arterial Disease (PAD): Thrombus Burden Assessed by Optical Coherence Tomography Terminated NCT02407314 Phase 4 Aspirin;Aspirin + Ticagrelor
37 Effect of Normalization of Fasting Glucose by Intensified Insulin Therapy on the Incidence of Restenosis After Peripheral Angioplasty in Patients With Type 2 Diabetes. Terminated NCT01150617 Phase 4 Insulin glargine plus insulin analogues
38 A Double-blind, Randomized, Parallel Design Two Center Study to Compare the Effect of Vorapaxar vs. Placebo on Lower Extremity Vein Graft Maturation, Remodeling, and Function Withdrawn NCT02975583 Phase 4 Vorapaxar;Placebos
39 Evaluation of Ranolazine on Skeletal Muscle Endpoints During Exercise In Subjects With Chronic Angina and Peripheral Arterial Disease Withdrawn NCT00657514 Phase 4 Ranolazine;Placebo
40 Proteomics and Stem Cell Therapy as a New Vascularization Strategy Withdrawn NCT02408991 Phase 4 Neupogen
41 Thalidomide for the Treatment of Malnutrition Inflammation Syndrome in Peritoneal Dialysis Patients: A Randomized Control Trial Withdrawn NCT00390247 Phase 4 thalidomide
42 Stem Cells In Wound Healing With Collagen Matrix as a Carrier Withdrawn NCT02314416 Phase 4
43 A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers Withdrawn NCT00338702 Phase 4
44 Distal Venous Arterialisation in the Treatment of Critical Ischemia of Lower Limb Unknown status NCT01211925 Phase 2, Phase 3 Aspirin
45 An Efficacy and Safety Study to Evaluate Ranger Drug-eluting Balloon for Below the Knee Angioplasty in Patients With Critical Limb Ischemia Unknown status NCT02856230 Phase 2, Phase 3
46 Study of Parameters of Infracyanine Angiography as Diagnostic Tool of Critical Limb Ischemia Unknown status NCT02820467 Phase 3
47 Prospektive, Randomisierte Und Kontrollierte Studie Zum Einfluss Des VADOplex-Systems Auf Die Lebensqualität im Rahmen Der Behandlung Der Chronisch-kritischen Extremitätenischämie im Stadium IV Nach Fontaine Unknown status NCT02034539 Phase 2, Phase 3
48 The Impact of Repeated Bilateral Limb Remote Ischemic Conditioning on Patients With Chronic Cerebral Ischemia: Establishment of Optimized Algorithm on the Basis of Feasibility, Safety and Efficacy Unknown status NCT03105141 Phase 2, Phase 3
49 Safety and Effectiveness of the SurgWerksTM-CLI Kit and VXPTM System for the Rapid Intra-operative Aspiration, Preparation and Intramuscular Injection of Concentrated Autologous Bone Marrow Cells Into the Ischemic Index Limb of Rutherford Category 5 Non-Reconstructable Critical Limb Ischemia Patients Unknown status NCT02538978 Phase 3
50 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia A Double Blind, Placebo Controlled, Study in Diabetic and Non-diabetic Patients Unknown status NCT00539266 Phase 2, Phase 3

Search NIH Clinical Center for Limb Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Limb Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Limb Ischemia:
ACP-01, autologous angiogenic precursor cells for critical limb ischemia
ACT34-CLI, bone marrow-derived cells for critical limb ischemia
ACY001, bone marrow-derived hematopoietic stem cells for treatment of critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Angiocell, bone marrow-derived stem cells for treatment of critical limb ischemia
Autologous CD133+ cells for treatment of critical limb ischemia
Autologous endothelial progenitor cells for the treatment of critical limb ischemia
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
BMAC, autologous bone marrow aspirate concentrate for critical limb ischemia
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for critical limb ischemia
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Bone marrow-derived stem cells for treatment of critical limb ischemia and diabetic foot ulcer
Bone marrow-derived stem cells for treatment of diabetic foot ulcers
Enriched bone marrow-derived progenitor cells for ischemic diseases
ERCs, endometrial regenerative cells for critical limb ischemia
Hematopoietic stem cells for limb ischemia and diabetic neuropathy
itMSC, bone marrow-derived mesenchymal stem cells for cardiovascular diseases
Ixmyelocel-T, mesenchymal stem cells and myocytes for critical limb ischemia
Mesendo, stem cell combination for treatment of limb ischemia
MultiGeneAngio, genetically modified endothelial and smooth muscle cells for vascular disease
PDA002, Placenta-derived cells for vascular disease
Peripheral blood-derived hematopoietic stem cells for leg gangrene
PLX-PAD, placental-derived mesenchymal-like stromal cells for peripheral artery disease
ReN009, human neural stem cells for peripheral arterial disease
RNL-Astrostem, adipose-derived mesenchymal stem cells for treatment of peripheral vascular diseases
StempeucelCLI, mesenchymal stem cells for vascular diseases
Umbilical cord blood stem cells for treatment of critical limb ischemia
Embryonic/Adult Cultured Cells Related to Limb Ischemia:
Angiogenic cell precursors
Bone marrow-derived CD34+ stem cells (ACT34) PMIDs: 22163120 23192920 9020076
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell PMIDs: 19558779
Bone marrow-derived mononuclear cells (family) PMIDs: 17394441 23586040 21216483
Peripheral blood-derived endothelial progenitor cells (family)
Peripheral blood-derived endothelial cells PMIDs: 18388019 19448678
Peripheral blood-derived hematopoietic stem cells PMIDs: 18388019
Bone Marrow Aspirate Concentrated Nucleated Cells (BMAC) PMIDs: 15995108 18351022 19896796 19500466 22019148
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Tissue repair cells PMIDs: 17394441 23586040
Bone marrow-derived mesenchymal stem cells PMIDs: 21216483
Bone marrow-derived progenitor cells
Endometrial regenerative cells PMIDs: 18005405 18713449 19232091
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T) PMIDs: 22453769 22776246 21684715
Bone marrow-derived mononuclear cells PMIDs: 21586448
Bone marrow-derived mesenchymal stem cells PMIDs: 21586448
Genetically modified vein-derived endothelial cells
MultiGeneAngio, transduced vein-derived smooth muscle cells
Genetically modified vein-derived smooth muscle
MultiGeneAngio, transduced vein-derived endothelial cells
Placenta-derived cells
Peripheral blood-derived hematopoietic stem cells
Placenta-derived adherent stromal cell (PLX) PMIDs: 18154467 19526389 19478280
Neural stem cell line (CTX0E03) PMIDs: 23067568
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080
Bone marrow-derived mesenchymal stem cells (Stempeucel) PMIDs: 23307180 18720444 22731756
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Limb Ischemia

Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

40
Bone, Endothelial, Bone Marrow, Heart, Skeletal Muscle, Kidney, Lung
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Limb Ischemia:
# Tissue Anatomical CompartmentCell Relevance
1 Limb Pelvic Girdle Bone Marrow Stromal Cells Potential therapeutic candidate
2 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
3 Placenta Chorionic Villus Chorionic Mesenchymal Stromal Cells Potential therapeutic candidate
4 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
5 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 7302)
# Title Authors PMID Year
1
MicroRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia. 61
32358022 2020
2
Analysis of the Safety and Efficacy of the Endovascular Treatment for Acute Limb Ischemia with Percutaneous Pharmacomechanical Thrombectomy Compared with Catheter-Directed Thrombolysis. 61
31863953 2020
3
Cell-modified bioprinted microspheres for vascular regeneration. 61
32409053 2020
4
Perioperative Outcomes of Lower Extremity Revascularization for Rest Pain and Tissue Loss. 61
31756416 2020
5
Limb Salvage Does Not Predict Functional Limb Outcome after Revascularization for Traumatic Acute Limb Ischemia. 61
31676382 2020
6
Adverse Cardiac Events and Mortality in Patients with Critical Limb Ischemia. 61
31712188 2020
7
Real-World Outcomes of EKOS Ultrasound-Enhanced Catheter-Directed Thrombolysis for Acute Limb Ischemia. 61
31917220 2020
8
Kissing Balloon Technique for Infrapopliteal Angioplasty in Patients with Critical Limb Ischemia. 61
31918037 2020
9
Single-center experience with Indigo aspiration thrombectomy for acute lower limb ischemia. 61
31918998 2020
10
Acute Thrombosis of an Aortic Prosthetic Graft in a Patient with Severe COVID-19-Related Pneumonia. 61
32360432 2020
11
The Influence of Preoperative Anemia on Clinical Outcomes After Infrainguinal Bypass Surgery. 61
31863946 2020
12
The Medical and Endovascular Treatment of PAD: A Review of the Guidelines and Pivotal Clinical Trials. 61
30573160 2020
13
Implications of Renal Disease in Patients Undergoing Peripheral Arterial Interventions. 61
32471675 2020
14
Endarterectomy for Isolated Atherosclerotic Lesions of the Popliteal Artery. 61
32044342 2020
15
A Prospective Randomized Blinded Trial of Remote Ischemic Preconditioning in Children Undergoing Cardiac Surgery. 61
31870925 2020
16
Endovascular and Surgical Management of Subclavian Artery Occlusive Disease: Early and Long-Term Outcomes. 61
31863950 2020
17
A Hybrid Technique to Treat Iliofemoral Lesions Using a Covered Stent Associated with Open Femoral Repair. 61
31866550 2020
18
Selective Use of Anticoagulation or Dual Antiplatelet Therapy for Patients with Extra-anatomic Bypasses. 61
31931126 2020
19
Acute Limb Ischemia Secondary to Patent Foramen Ovale-Mediated Paradoxical Embolism: A Case Report and Systematic Review of the Literature. 61
31904517 2020
20
The Controlling Nutritional Status Score is Significantly Associated with Complete Ulcer Healing in Patients with Critical Limb Ischemia. 61
31917224 2020
21
Arterial Reconstruction for Patients with Chronic Limb Ischemia Improves Ambulatory Function and Health-related Quality of Life. 61
32035265 2020
22
Treatment of lower limb arterial disease by Dardik graft: It takes one to know one. 61
32571562 2020
23
Single Tertiary Care Center Outcomes After Lower Extremity Cadaveric Vein Bypass for Limb Salvage. 61
32489155 2020
24
Assessment of foot perfusion: Overview of modalities, review of evidence, and identification of evidence gaps. 61
32362209 2020
25
Characterization of Proangiogenic Monocytes from Blood in Patients with Chronic Ischemic Diabetic Foot Ulcers and Controls. 61
32423362 2020
26
Systemic Embolization as the Initial Presentation of a Rare Cause of Infective Endocarditis. 61
32528787 2020
27
Long-Term Cilostazol Treatment and Predictive Factors on Outcomes of Endovascular Intervention in Patients with Diabetes Mellitus and Critical Limb Ischemia. 61
32564334 2020
28
Re: Risk of Death and Amputation with Use of Paclitaxel-Coated Balloons in the Infrapopliteal Arteries for Treatment of Critical Limb Ischemia: A Systematic Review and Meta-analysis of Randomized Controlled Trials. 61
32376179 2020
29
Re: Risk of Death and Amputation with Use of Paclitaxel-Coated Balloons in the Infrapopliteal Arteries for Treatment of Critical Limb Ischemia: A Systematic Review and Meta-analysis of Randomized Controlled Trials. 61
32376180 2020
30
Reply to: "Re: Risk of Death and Amputation with Use of Paclitaxel-Coated Balloons in the Infrapopliteal Arteries for Treatment of Critical Limb Ischemia: A Systematic Review and Meta-analysis of Randomized Controlled Trials". 61
32376181 2020
31
New Surgical Circulatory Support System Outcomes. 61
32541335 2020
32
Remote ischemic conditioning in active ulcerative colitis: An explorative randomized clinical trial. 61
32533085 2020
33
Prophylactic intra-aortic balloon pump in patients with left main disease undergoing off-pump coronary artery bypass grafting. 61
32493248 2020
34
Keap1-Nrf2 signaling pathway in angiogenesis and vascular diseases. 61
32336035 2020
35
Soluble receptor for advanced glycation end-products promotes angiogenesis through activation of STAT3 in myocardial ischemia/reperfusion injury. 61
32333220 2020
36
Hybrid surgical procedure for treatment of persistent sciatic artery with limb ischemia: A case report. 61
32540153 2020
37
Origin of the 31 P MR signal at 5.3 ppm in patients with critical limb ischemia. 61
32180296 2020
38
Critical limb ischemia in the very elderly patients: A growing problem. 61
30857798 2020
39
Dynamic Volume Perfusion CT of the Foot in Critical Limb Ischemia: Response to Percutaneous Revascularization. 61
32097028 2020
40
Multivessel tibial revascularization does not improve outcomes in patients with critical limb ischemia. 61
31685281 2020
41
A mortality prediction model for elderly patients with critical limb ischemia. 61
31711729 2020
42
Platelet-to-lymphocyte and Neutrophil-to-lymphocyte Ratios Predict Target Vessel Restenosis after Infrainguinal Angioplasty with Stent Implantation. 61
32503291 2020
43
The Efficacy of Percutaneous Transluminal Angioplasty on the Limb Salvage and Recovery of Symptoms in Patients With Buerger's Disease With Critical Limb Ischemia. 61
32479418 2020
44
"Noninfective Endocarditis": A Case Report of Hereditary Coagulation Disorders in a 28-Year-Old Male. 61
32521783 2020
45
Evaluation of the proliferative potential of skin keratinocytes and fibroblasts isolated from critical limb ischemia patients. 61
32435674 2020
46
Cost-Effectiveness of Coronary and Peripheral Artery Disease Antithrombotic Treatments in Finland. 61
32519113 2020
47
Impact of left ventricular diastolic dysfunction on long-term outcome in patients with lower extremity artery disease. 61
31964546 2020
48
Management of acute limb ischemia related to underlying pheochromocytoma. 61
32510032 2020
49
Effective single-session percutaneous nonpharmacologic mechanical thrombectomy for phlegmasia cerulea dolens. 61
32322779 2020
50
Multispectral optoacoustic tomography of muscle perfusion and oxygenation under arterial and venous occlusion: A human pilot study. 61
32134550 2020

Variations for Limb Ischemia

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.23 VWF VEGFA TNF TEK PGF NOS3
2
Show member pathways
14.07 VWF VEGFA TNF TEK SIGLEC5 NOS3
3
Show member pathways
13.89 VEGFA TNF TEK PGF KDR IL6
4
Show member pathways
13.74 VEGFA TEK PGF NOS3 MMP9 KDR
5
Show member pathways
13.72 TNF TEK NOS3 KDR IL6 HGF
6
Show member pathways
13.61 VEGFA TNF TEK PGF KDR IL6
7
Show member pathways
13.6 TEK PGF NOS3 KDR IL6 HGF
8
Show member pathways
13.54 VWF VEGFA TNF TEK MMP9 KDR
9
Show member pathways
13.42 VWF VEGFA TNF TEK MMP9 IL6
10
Show member pathways
13.42 TNF TEK PGF NOS3 KDR IL6
11
Show member pathways
13.37 TEK PGF KDR IL6 HGF FGF2
12
Show member pathways
13.36 VWF VEGFA TEK SELE NOS3 HGF
13
Show member pathways
13.35 TNF TEK PGF KDR IL6 HGF
14
Show member pathways
13.32 VEGFA TNF TEK PGF NOS3 KDR
15
Show member pathways
13.11 PGF KDR IL6 HGF FGF2 CXCL12
16
Show member pathways
13.11 VEGFA TNF SELE MMP9 KDR IL6
17
Show member pathways
13.09 PGF KDR IL6 HIF1A HGF FGF2
18
Show member pathways
13.02 VEGFA TNF IL6 HIF1A FGF2 CXCL12
19 12.9 VEGFA PGF MMP9 IL6 HIF1A HGF
20
Show member pathways
12.84 VEGFA TEK PGF KDR HGF FGF2
21
Show member pathways
12.83 VWF VEGFA TNF TEK PGF NOS3
22
Show member pathways
12.8 TNF PGF KDR IL6 HGF FGF2
23 12.79 VEGFA TNF TEK PGF KDR HGF
24
Show member pathways
12.73 VEGFA NOS3 MMP9 KDR CXCL12 CCL2
25
Show member pathways
12.69 VEGFA KDR IL6 HIF1A HGF FGF2
26
Show member pathways
12.67 TNF TEK NOS3 IL6 FGF2 CCL2
27
Show member pathways
12.49 TEK PGF KDR IL6 HGF FGF2
28
Show member pathways
12.46 VEGFA SELE NOS3 KDR CCL2
29
Show member pathways
12.37 TNF MMP9 IL6 CCL2
30
Show member pathways
12.37 TNF IL6 CXCL12 CCL2
31
Show member pathways
12.35 TNF PGF KDR IL6 HGF FGF2
32 12.24 VEGFA TNF MMP9 MIR21 KDR HIF1A
33 12.23 VEGFA TNF MMP9 IL6
34 12.22 VEGFA TNF IL6 HIF1A
35 12.18 VEGFA KDR IL6 HGF FGF2
36 12.17 TEK KDR FGF2 ANGPT2
37 12.12 VEGFA TNF SELE NOS3 MMP9 KDR
38 12.08 TNF SELE MMP9 IL6 CCL2
39 12.06 TNF MMP9 IL6 CCL2
40 12.01 VEGFA TEK NOS3 IL6 HIF1A ANGPT2
41
Show member pathways
11.97 VEGFA PGF NOS3 KDR HIF1A
42 11.95 VEGFA TNF SELE NOS3 IL6 CCL2
43 11.9 VEGFA TNF TEK IL6 CXCL12 CCL2
44 11.81 VEGFA TNF MMP9 IL6 HIF1A HGF
45 11.78 PGF IL6 HGF FGF2 CXCL12
46
Show member pathways
11.74 VEGFA TNF SELE MMP9 IL6
47 11.73 NOS3 MMP9 HIF1A
48 11.72 VEGFA HIF1A CXCL12
49 11.72 VEGFA MMP9 FGF2
50 11.68 TNF MMP9 IL6 HGF FGF2 CCL2

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 VWF VEGFA TNF TEK PGF MMP9
2 membrane raft GO:0045121 9.56 TNF TEK SELE KDR
3 extracellular space GO:0005615 9.44 VEGFA TNF SELE PGF MMP9 MIR21
4 platelet alpha granule lumen GO:0031093 9.33 VWF VEGFA HGF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.36 VEGFA TEK PGF IL6 HIF1A FGF2
2 multicellular organism development GO:0007275 10.27 VEGFA TNF TEK PGF KDR FGF2
3 positive regulation of gene expression GO:0010628 10.12 VEGFA TNF NOS3 MIR21 IL6 HIF1A
4 positive regulation of cell proliferation GO:0008284 10.12 VEGFA PGF MIR21 KDR IL6 FGF2
5 negative regulation of apoptotic process GO:0043066 10.06 VEGFA TEK MMP9 MIR21 KDR IL6
6 MAPK cascade GO:0000165 10.05 TNF TEK HGF FGF2 CCL2
7 extracellular matrix organization GO:0030198 10.04 VWF TNF MMP9 KDR FGF2
8 leukocyte migration GO:0050900 10.02 TNF TEK SELE ANGPT2
9 cellular response to lipopolysaccharide GO:0071222 10.01 TNF MIR21 IL6 CCL2
10 regulation of cell shape GO:0008360 10 VEGFA MIR21 KDR CCL2
11 positive regulation of protein kinase B signaling GO:0051897 10 TNF TEK MIR21 HGF FGF2
12 positive regulation of cell migration GO:0030335 10 VEGFA MMP9 MIR21 KDR HGF CXCL12
13 negative regulation of angiogenesis GO:0016525 9.97 TEK MIR503 MIR21 ANGPT2
14 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 TNF TEK MIR21 KDR FGF2 CCL2
15 positive regulation of MAPK cascade GO:0043410 9.96 TEK KDR IL6 FGF2
16 negative regulation of gene expression GO:0010629 9.95 VEGFA TNF MIR21 KDR HIF1A FGF2
17 cytokine-mediated signaling pathway GO:0019221 9.92 VEGFA TNF MMP9 IL6 HIF1A HGF
18 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.91 VEGFA TNF HGF
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 VEGFA TNF IL6
20 response to hypoxia GO:0001666 9.91 VEGFA TEK PGF HIF1A CXCL12 ANGPT2
21 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.9 VEGFA PGF KDR
22 positive regulation of osteoblast differentiation GO:0045669 9.9 MIR21 IL6 HGF
23 positive regulation of MAP kinase activity GO:0043406 9.9 VEGFA TNF FGF2
24 humoral immune response GO:0006959 9.89 TNF IL6 CCL2
25 positive regulation of cell adhesion GO:0045785 9.88 VEGFA TNF CXCL12
26 positive regulation of endothelial cell migration GO:0010595 9.88 VEGFA TEK MIR21 KDR
27 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.88 TNF TEK MIR21 KDR HGF
28 positive regulation of cell division GO:0051781 9.87 VEGFA PGF FGF2
29 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.87 TNF MMP9 MIR21 FGF2
30 positive chemotaxis GO:0050918 9.86 VEGFA PGF HGF FGF2
31 positive regulation of protein phosphorylation GO:0001934 9.86 VEGFA TNF TEK PGF MMP9 MIR21
32 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.85 TNF HIF1A FGF2
33 negative regulation of endothelial cell proliferation GO:0001937 9.85 TNF MIR503 MIR21
34 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.85 VEGFA KDR FGF2
35 protein kinase B signaling GO:0043491 9.85 TNF KDR CCL2
36 negative regulation of blood vessel endothelial cell migration GO:0043537 9.85 TNF MIR503 FGF2 ANGPT2
37 lipopolysaccharide-mediated signaling pathway GO:0031663 9.84 TNF NOS3 CCL2
38 animal organ regeneration GO:0031100 9.84 PGF HGF CXCL12 ANGPT2
39 positive regulation of focal adhesion assembly GO:0051894 9.81 VEGFA TEK KDR
40 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.81 VEGFA MIR503 MIR21
41 sprouting angiogenesis GO:0002040 9.81 VEGFA TEK PGF KDR
42 angiogenesis GO:0001525 9.81 VEGFA TEK PGF NOS3 KDR HIF1A
43 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.8 TNF MIR21 IL6
44 cell migration involved in sprouting angiogenesis GO:0002042 9.8 VEGFA KDR FGF2
45 positive regulation of chemokine production GO:0032722 9.79 TNF IL6 HIF1A
46 vascular endothelial growth factor signaling pathway GO:0038084 9.79 VEGFA PGF KDR
47 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.78 TNF MIR21 IL6
48 induction of positive chemotaxis GO:0050930 9.77 VEGFA PGF CXCL12
49 positive regulation of blood vessel endothelial cell migration GO:0043536 9.77 VEGFA NOS3 KDR HIF1A FGF2
50 regulation of neuroinflammatory response GO:0150077 9.74 MMP9 IL6

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.91 VWF VEGFA TNF TEK PGF MMP9
2 integrin binding GO:0005178 9.62 VWF KDR FGF2 CXCL12
3 chemoattractant activity GO:0042056 9.46 VEGFA PGF HGF FGF2
4 cytokine activity GO:0005125 9.43 VEGFA TNF IL6 FGF2 CXCL12 CCL2
5 vascular endothelial growth factor receptor binding GO:0005172 9.37 VEGFA PGF
6 growth factor activity GO:0008083 9.1 VEGFA PGF IL6 HGF FGF2 CXCL12

Sources for Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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