MCID: LMB062
MIFTS: 51

Limb Ischemia

Categories: Cardiovascular diseases

Aliases & Classifications for Limb Ischemia

MalaCards integrated aliases for Limb Ischemia:

Name: Limb Ischemia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050852
UMLS 73 C2945695

Summaries for Limb Ischemia

MalaCards based summary : Limb Ischemia is related to critical limb ischemia and peripheral artery disease. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Aspirin and Menthol have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related phenotypes are cardiovascular system and cellular

Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 critical limb ischemia 33.3 HGF HIF1A IL6 TNF VEGFA VWF
2 peripheral artery disease 30.1 ACE IL6 NOS3 VEGFA
3 endocarditis 30.0 IL6 TNF TNNI3
4 infective endocarditis 29.8 IL6 TNF TNNI3
5 intermittent claudication 29.7 ACE IL6 VEGFA VWF
6 ischemia 29.4 ACE CXCL12 EDN1 HIF1A NOS3 VEGFA
7 peripheral vascular disease 29.4 ACE IL6 VEGFA VWF
8 connective tissue disease 28.7 ACE EDN1 IL6 TNF
9 diabetes mellitus 28.5 ACE EDN1 IL6 NOS3 TNF VEGFA
10 coronary artery anomaly 27.6 ACE EDN1 IL6 NOS3 TNNI3 VWF
11 vascular disease 27.3 ACE EDN1 FGF2 IL6 NOS3 TNF
12 dilated cardiomyopathy 27.2 ACE EDN1 IL6 NOS3 TNF TNNI3
13 arteries, anomalies of 26.6 ACE EDN1 IL6 NOS3 PGF TNF
14 scorpion envenomation 10.8 IL6 TNF
15 intravascular papillary endothelial hyperplasia 10.8 HIF1A VEGFA
16 hemifacial spasm 10.8 NOS3 VEGFA
17 wrinkles 10.8 HGF VEGFA
18 leukomalacia 10.8 IL6 TNF
19 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
20 eales disease 10.6 IL6 TNF VEGFA
21 rosacea 10.6 IL6 TNF VEGFA
22 infiltrating angiolipoma 10.6 VEGFA VWF
23 cerebral artery occlusion 10.6 HIF1A NOS3 TNF
24 laryngitis 10.6 FGF2 IL6 TNF
25 female reproductive system disease 10.6 IL6 TNF VEGFA
26 streptococcal toxic-shock syndrome 10.6 IL6 TNF
27 null-cell leukemia 10.5 IL6 TNF
28 chronic mountain sickness 10.5 EDN1 NOS3 VEGFA
29 angiodysplasia 10.5 FGF2 VEGFA VWF
30 lymphangiosarcoma 10.5 TNF VEGFA VWF
31 osteosclerotic myeloma 10.5 IL6 TNF VWF
32 angiokeratoma circumscriptum 10.5 KDR VEGFA
33 meconium aspiration syndrome 10.5 EDN1 IL6 TNF
34 gastrointestinal system cancer 10.5 IL6 TNF VEGFA
35 diffuse meningeal melanocytosis 10.5 EDN1 HGF
36 varicose veins 10.5 HIF1A VEGFA VWF
37 mesangial proliferative glomerulonephritis 10.5 EDN1 FGF2 IL6
38 apnea, obstructive sleep 10.4 EDN1 IL6 TNF
39 pyogenic granuloma 10.4 ANGPT2 TEK VEGFA
40 complex regional pain syndrome 10.4 EDN1 IL6 TNF
41 takayasu arteritis 10.4 IL6 TNF VWF
42 plasmodium vivax malaria 10.4 ANGPT2 IL6 TNF
43 arteriovenous malformations of the brain 10.4 IL6 KDR VEGFA
44 pericardial effusion 10.4 FGF2 HIF1A IL6 VEGFA
45 atherosclerosis susceptibility 10.4 IL6 NOS3 TNF
46 angiomatous meningioma 10.4 FGF2 KDR VEGFA
47 endotheliitis 10.4
48 capillary hemangioma 10.4 KDR TEK VEGFA
49 dry eye syndrome 10.3 FGF2 HGF IL6 TNF
50 parasitic protozoa infectious disease 10.3 IL6 KDR TNF

Graphical network of the top 20 diseases related to Limb Ischemia:



Diseases related to Limb Ischemia

Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 TNNI3 TEK VEGFA TNF VWF ANGPT2
2 cellular MP:0005384 10.29 VEGFA TNF VWF FGF2 ANGPT2 HGF
3 homeostasis/metabolism MP:0005376 10.29 PGF TEK VEGFA TNF VWF FGF2
4 mortality/aging MP:0010768 10.28 TNNI3 TEK VEGFA TNF VWF FGF2
5 hematopoietic system MP:0005397 10.27 TEK VEGFA TNF VWF FGF2 HGF
6 growth/size/body region MP:0005378 10.25 TNF PGF TEK VEGFA ACE HGF
7 immune system MP:0005387 10.2 PGF VEGFA TNF VWF ANGPT2 CXCL12
8 digestive/alimentary MP:0005381 10.14 VEGFA TNF VWF ANGPT2 EDN1 HIF1A
9 embryo MP:0005380 10.13 TNF PGF TEK VEGFA HGF EDN1
10 muscle MP:0005369 10.11 TNNI3 TEK VEGFA TNF CXCL12 HIF1A
11 liver/biliary system MP:0005370 10.09 VEGFA TNF HGF CXCL12 HIF1A ACE
12 nervous system MP:0003631 10 TEK VEGFA TNF VWF FGF2 CXCL12
13 neoplasm MP:0002006 9.87 PGF VEGFA TNF FGF2 ACE HIF1A
14 respiratory system MP:0005388 9.81 TNNI3 VEGFA TNF ANGPT2 PGF HIF1A
15 skeleton MP:0005390 9.56 TNF VEGFA FGF2 EDN1 HIF1A KDR
16 vision/eye MP:0005391 9.32 TEK VEGFA TNF FGF2 ANGPT2 HIF1A

Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 233)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-78-2 2244
2
Menthol Approved Phase 4,Phase 2,Phase 3,Not Applicable 2216-51-5 16666
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
5
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
6
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
7
Metronidazole Approved Phase 4 443-48-1 4173
8
Povidone Approved Phase 4 9003-39-8
9
Povidone-iodine Approved Phase 4 25655-41-8
10
Teicoplanin Approved, Investigational Phase 4 61036-62-2
11
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 33069-62-4 36314
12
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 9005-49-6 772 46507594
13
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2 73963-72-1 2754
14
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 120202-66-6, 113665-84-2 60606
15
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
16
Lenograstim Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 135968-09-1
17
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 149351 5280723
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
19
Dalteparin Approved Phase 4,Phase 2 9005-49-6
20 Defibrotide Approved, Investigational Phase 4 83712-60-1
21
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
22
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
23
Ramipril Approved Phase 4 87333-19-5 5362129
24
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
25
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 23994
26
Febuxostat Approved Phase 4 144060-53-7 134018
27
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
28
Insulin Glargine Approved Phase 4 160337-95-1
29
Ephedrine Approved Phase 4 299-42-3 9294
30
Norepinephrine Approved Phase 4 51-41-2 439260
31
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
32
Phenylephrine Approved Phase 4 59-42-7 6041
33
Pseudoephedrine Approved Phase 4 90-82-4 7028
34
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
35 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
36
Uric Acid Experimental, Investigational Phase 4 69-93-2 1175
37 Amoxicillin-Potassium Clavulanate Combination Phase 4
38 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
39 Antibiotics, Antitubercular Phase 4,Phase 2,Not Applicable
40 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
41 Anti-Infective Agents, Local Phase 4,Not Applicable
42 Antiparasitic Agents Phase 4
43 Antiprotozoal Agents Phase 4
44 Antitubercular Agents Phase 4
45 beta-Lactamase Inhibitors Phase 4
46 Blood Substitutes Phase 4,Phase 2
47 cadexomer iodine Phase 4,Not Applicable
48 Chlorhexidine gluconate Phase 4
49 Clavulanic Acid Phase 4
50 Clindamycin palmitate Phase 4

Interventional clinical trials:

(show top 50) (show all 462)
# Name Status NCT ID Phase Drugs
1 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Unknown status NCT01173094 Phase 4
2 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) Unknown status NCT01171703 Phase 4
3 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
4 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
5 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
6 Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) Completed NCT00906022 Phase 4
7 Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia Completed NCT02369809 Phase 4 Neovasculgen®
8 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation Completed NCT01558505 Phase 4
9 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
10 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
11 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV Completed NCT00596752 Phase 4 Alprostadil
12 DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
13 Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) Completed NCT00300690 Phase 4
14 Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions Completed NCT00764777 Phase 4
15 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
16 Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans Completed NCT02117206 Phase 4 L-arginine (L-arginine Veyron);Nacl
17 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Completed NCT01983449 Phase 4 Dexamethasone Sodium Phosphate Injection, USP
18 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
19 AngioSeal Versus Radial Approach in Acute Coronary Syndrome Completed NCT01653587 Phase 4
20 Instrumental Sealing of Arterial Puncture Site Closure Device Versus Manual Compression Trial Completed NCT01389375 Phase 4
21 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
22 Optimization of Treatment in Patients With Severe Peripheral Ischemia (Fontaine Stage IIb) Completed NCT01718288 Phase 4 iloprost;Standard Treatment (aspirin.....),
23 Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants Completed NCT01037530 Phase 4 Ramipril
24 The Study to Compare SMART Nitinol Stent and Balloon Angioplasty Completed NCT00309595 Phase 4
25 The Study to Compare the Cordis SMART™ Stent System With the Bard® Luminexx™ Stent Completed NCT00235131 Phase 4
26 DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions Completed NCT01412463 Phase 4
27 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Recruiting NCT02563535 Phase 4
28 Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Recruiting NCT02807779 Phase 4 Dexamethasone infusion
29 Lowering-hyperuricemia Treatment on Cardiovascular Outcomes in Peritoneal Dialysis Patients Recruiting NCT03200210 Phase 4 Febuxostat;Placebo
30 Vascular Closure Device Versus Transradial Approach in Primary Percutaneous Coronary Intervention Recruiting NCT02831166 Phase 4
31 Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery Recruiting NCT02085551 Phase 4
32 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Not yet recruiting NCT02829151 Phase 4 Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
33 Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE) Not yet recruiting NCT03549923 Phase 4 Esmolol;Standard care
34 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Terminated NCT00403780 Phase 4 pregabalin;placebo
35 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
36 Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty Terminated NCT01150617 Phase 4 Insulin glargine plus insulin analogues
37 Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients Terminated NCT02203630 Phase 4 Phenylephrine;Norepinephrine
38 AGIR Study: Angio-Seal in Interventional Radiology Terminated NCT01911403 Phase 4
39 Use Art-assist and Neupogen to Treat Chronic Limb Ischemia Withdrawn NCT02408991 Phase 4 Neupogen
40 Treatment of Chronic Critical Limb Ischemia With G-CSF-mobilized Autologous Peripheral Blood Mononuclear Cells Unknown status NCT01833585 Phase 3
41 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia Unknown status NCT00539266 Phase 2, Phase 3
42 VADOplex Critical Limb Ischemia Study Unknown status NCT02034539 Phase 2, Phase 3
43 Distal Venous Arterialisation of Ischemic Limb Unknown status NCT01211925 Phase 2, Phase 3 Aspirin
44 Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Unknown status NCT00434616 Phase 2, Phase 3
45 Transfer of Cardioprotection During RIPC Unknown status NCT01956708 Phase 2, Phase 3
46 Remote Ischemic Preconditioning in Coronary Artery Bypass Grafting With Cold Crystalloid Cardioplegic Arrest Unknown status NCT01406678 Phase 2, Phase 3 isoflurane+sufentanil anesthesia
47 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
48 Transfusion Requirements in Critically Ill Oncologic Patient Unknown status NCT01648946 Phase 3
49 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
50 Claudication: Exercise Versus Endoluminal Revascularization (CLEVER) Unknown status NCT00132743 Phase 3 Cilostazol

Search NIH Clinical Center for Limb Ischemia

Genetic Tests for Limb Ischemia

Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

41
Bone, Bone Marrow, Kidney, Heart, Endothelial, Brain, Liver

Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 847)
# Title Authors Year
1
Human primary CD34<sup>+</sup> cells transplantation for critical limb ischemia. ( 29893031 )
2018
2
Acute Limb Ischemia Secondary to Native Artery Occlusion: Results of a Contemporary Case Series. ( 29404750 )
2018
3
Efficacy Outcomes of Endovascular Versus Surgical Revascularization in Critical Limb Ischemia: Results From a Prospective Cohort Study. ( 29355026 )
2018
4
Acute Limb Ischemia-Much More Than Just a Lack of Oxygen. ( 29373539 )
2018
5
Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion. ( 29960153 )
2018
6
Lower limb ischemia due to popliteal artery compression by Baker cyst. ( 29942891 )
2018
7
Lower extremity bypass and endovascular intervention for critical limb ischemia fail to meet Society for Vascular Surgery's objective performance goals for limb-related outcomes in a contemporary national cohort. ( 29937289 )
2018
8
Rationale and design of the SAIL trial for intramuscular injection of allogeneic mesenchymal stromal cells in no-option critical limb ischemia. ( 29242062 )
2018
9
Natural language processing of clinical notes for identification of critical limb ischemia. ( 29425639 )
2018
10
Spinal Cord Stimulation Improves the Microvascular Perfusion Insufficiency Caused by Critical Limb Ischemia. ( 29377343 )
2018
11
Effect of Intramuscular Administration of Mesenchymal Stem Cells and Erythropoietin on Angiogenesis in Critical Limb Ischemia. ( 29796803 )
2018
12
Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan. ( 29386474 )
2018
13
Acute limb ischemia of the lower extremity associated with left upper lobe surgery for primary lung cancer. ( 29942889 )
2018
14
Simultaneous Hybrid Operation Common Femoral Endarterectomy and Endovascular Treatment in Multilevel Peripheral Arterial Disease with Critical Limb Ischemia. ( 29915480 )
2018
15
Clinical significance of perioperative changes in ankle-brachial index with regard to extremity-related outcome in non-diabetic patients with critical limb ischemia. ( 29911291 )
2018
16
Rationale and design of the Clinical and Histologic Analysis of Mesenchymal Stromal Cells in AmPutations (CHAMP) trial investigating the therapeutic mechanism of mesenchymal stromal cells in the treatment of critical limb ischemia. ( 29395424 )
2018
17
The Role of miR-126 in Critical Limb Ischemia Treatment Using Adipose-Derived Stem Cell Therapeutic Factor Concentrate and Extracellular Matrix Microparticles. ( 29371587 )
2018
18
MicroRNA-19 restores vascular endothelial cell function in lower limb ischemia-reperfusion injury through the KLF10-dependent TGF-I^1/Smad signaling pathway in rats. ( 29953651 )
2018
19
Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty. ( 29860903 )
2018
20
Pathophysiology of chronic limb ischemia. ( 29950791 )
2018
21
Efficacy of regional saturation of oxygen monitor using near-infrared spectroscopy for lower limb ischemia during minimally invasive cardiac surgery. ( 29938392 )
2018
22
One-Year Results of First-Line Treatment Strategies in Patients With Critical Limb Ischemia (CRITISCH Registry). ( 29968501 )
2018
23
The Incidence, Risk Factors, and Outcomes of Contrast-Induced Nephropathy In Patients With Critical Limb Ischemia Following Lower Limb Angiography. ( 29390867 )
2018
24
Impact of infection severity on clinical outcomes in critical limb ischemia with tissue loss after endovascular treatment. ( 29967952 )
2018
25
Field testing for the critical limb ischemia cost measure. ( 29801561 )
2018
26
Outcomes of Duplex guided paramalleolar and inframalleolar bypass in patients with critical limb ischemia. ( 29886216 )
2018
27
miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia. ( 29908843 )
2018
28
Mycotic Renal Artery Aneurysm Presenting as Critical Limb Ischemia in Culture-Negative Endocarditis. ( 29854544 )
2018
29
Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials. ( 29977308 )
2018
30
Reinterventions following endovascular revascularization in elderly with critical limb ischemia; an observational study. ( 29886205 )
2018
31
Clinical Outcomes after Isolated Infrapopliteal Revascularization in Hemodialysis Patients with Critical Limb Ischemia: Endovascular Therapy versus Bypass Surgery. ( 29367521 )
2018
32
Disease Burden and Clinical Outcomes Following Initial Diagnosis of Critical Limb Ischemia in the Medicare Population. ( 29798766 )
2018
33
BAD transmission and SAD distribution: a new scenario for critical limb ischemia. ( 29786411 )
2018
34
The influence of patients' nutritional status on the prevalence, course and treatment outcomes of lower limb ischemia: an overview of current evidence. ( 29385791 )
2018
35
Predictive factors of a poor outcome following revascularization for critical limb ischemia: implications for practice. ( 29792018 )
2018
36
Noninvasive measurements of tissue perfusion in critical limb ischemia. ( 29950790 )
2018
37
Assessment of Tissue Perfusion with Blood Oxygenation Level-Dependent Magnetic Resonance Imaging in Critical Limb Ischemia. ( 29968440 )
2018
38
Design Strategies for Global Clinical Trials of Endovascular Devices for Critical Limb Ischemia (CLI)a88- A Joint USA-Japanese Perspective. ( 29962385 )
2018
39
Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model. ( 29395422 )
2018
40
Cryptogenic acute limb ischemia: a retrospective cohort study defining a previously undescribed clinical entity. ( 29357035 )
2018
41
Endovascular Distal Plantar Vein Arterialization in Dialysis Patients With No-Option Critical Limb Ischemia and Posterior Tibial Artery Occlusion: A Technique for Limb Salvage in a Challenging Patient Subset. ( 29264998 )
2018
42
Recurrence of Critical Limb Ischemia After Endovascular Intervention in Patients with Diabetic Foot Ulcers. ( 29892493 )
2018
43
Thrombectomy Using Myocardial Biopsy Forceps in Acute Limb Ischemia Patients. ( 29887182 )
2018
44
Inframalleolar Interventions in Critical Limb Ischemia: Trailblazing the Path Toward the Final Frontier? ( 28057290 )
2017
45
Thrombolytic therapy for critical limb ischemia in a Jehovah's Witness with severe anemia. ( 29349406 )
2017
46
Isolated lower extremity vasculitis leading to progressive critical limb ischemia. ( 29349396 )
2017
47
Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation. ( 29410598 )
2017
48
Staged endovascular repair of critical limb ischemia in high risk patients: the procedural and clinical outcomes. ( 28884985 )
2017
49
Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes. ( 28900239 )
2017
50
Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects. ( 28789654 )
2017

Variations for Limb Ischemia

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.16 CXCL12 EDN1 FGF2 HGF HIF1A IL6
2
Show member pathways
13.86 ANGPT2 CXCL12 FGF2 HGF HIF1A IL6
3
Show member pathways
13.71 CXCL12 FGF2 HGF IL6 KDR NOS3
4
Show member pathways
13.66 ANGPT2 CXCL12 EDN1 HGF IL6 KDR
5
Show member pathways
13.56 CXCL12 FGF2 HGF IL6 KDR NOS3
6
Show member pathways
13.47 FGF2 HGF KDR TEK TNF VEGFA
7
Show member pathways
13.46 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
8
Show member pathways
13.37 FGF2 HGF HIF1A IL6 TEK TNF
9
Show member pathways
13.33 CXCL12 FGF2 HGF IL6 KDR PGF
10
Show member pathways
13.32 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
11
Show member pathways
13.31 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
12
Show member pathways
13.18 CXCL12 FGF2 HGF IL6 KDR NOS3
13
Show member pathways
13.07 CXCL12 FGF2 HGF IL6 KDR PGF
14
Show member pathways
13.07 ACE CXCL12 FGF2 HGF HIF1A IL6
15
Show member pathways
12.88 HGF KDR PGF VEGFA VWF
16 12.87 CXCL12 FGF2 HGF HIF1A IL6 PGF
17
Show member pathways
12.77 FGF2 HGF IL6 KDR VEGFA
18
Show member pathways
12.76 ANGPT2 FGF2 HGF KDR PGF TEK
19
Show member pathways
12.72 CXCL12 FGF2 HGF IL6 KDR PGF
20
Show member pathways
12.72 ANGPT2 FGF2 HGF IL6 KDR NOS3
21
Show member pathways
12.64 ANGPT2 FGF2 IL6 NOS3 TEK TNF
22 12.64 ANGPT2 FGF2 HGF KDR PGF TEK
23
Show member pathways
12.62 ANGPT2 FGF2 HIF1A IL6 TNF VEGFA
24
Show member pathways
12.56 KDR NOS3 TNF VEGFA
25
Show member pathways
12.39 KDR NOS3 PGF VEGFA
26 12.29 FGF2 HGF HIF1A KDR TNF VEGFA
27
Show member pathways
12.25 FGF2 KDR NOS3 VEGFA
28
Show member pathways
12.22 ACE IL6 TNF TNNI3
29 12.19 HIF1A IL6 TNF VEGFA
30 12.15 EDN1 KDR NOS3 TNF VEGFA
31 12.14 ANGPT2 FGF2 KDR TEK
32
Show member pathways
12.05 ANGPT2 CXCL12 FGF2 HGF IL6 KDR
33 12.01 FGF2 HGF IL6 KDR TNNI3 VEGFA
34 11.96 EDN1 IL6 NOS3 TNF VEGFA
35
Show member pathways
11.94 IL6 NOS3 TNF
36 11.93 EDN1 IL6 TNF
37
Show member pathways
11.91 HIF1A KDR NOS3 PGF VEGFA
38 11.89 CXCL12 IL6 TEK TNF VEGFA
39 11.86 FGF2 HGF HIF1A IL6 TNF VEGFA
40 11.8 ANGPT2 EDN1 HIF1A IL6 NOS3 TEK
41 11.75 CXCL12 EDN1 HIF1A VEGFA
42
Show member pathways
11.68 IL6 TNF VEGFA
43 11.66 EDN1 HIF1A NOS3 VEGFA
44 11.65 EDN1 FGF2 HGF IL6 TNF
45 11.6 FGF2 KDR TNNI3
46 11.6 FGF2 HGF IL6 VEGFA
47 11.58 HIF1A IL6 VEGFA
48 11.56 FGF2 KDR VEGFA
49 11.56 HGF IL6 TNF
50 11.52 FGF2 KDR VEGFA

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
2 extracellular region GO:0005576 9.44 ACE ANGPT2 CXCL12 EDN1 FGF2 HGF
3 platelet alpha granule lumen GO:0031093 9.43 HGF VEGFA VWF
4 Weibel-Palade body GO:0033093 9.16 EDN1 VWF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.99 HIF1A KDR TNF VEGFA
2 extracellular matrix organization GO:0030198 9.98 FGF2 KDR TNF VWF
3 cytokine-mediated signaling pathway GO:0019221 9.97 FGF2 HGF HIF1A IL6 TNF VEGFA
4 regulation of signaling receptor activity GO:0010469 9.97 CXCL12 EDN1 FGF2 HGF IL6 PGF
5 positive regulation of cell migration GO:0030335 9.96 CXCL12 EDN1 HGF KDR VEGFA
6 peptidyl-tyrosine phosphorylation GO:0018108 9.94 FGF2 HGF KDR TEK
7 positive regulation of protein kinase B signaling GO:0051897 9.93 FGF2 HGF TEK TNF
8 positive regulation of protein phosphorylation GO:0001934 9.91 HGF KDR TEK TNF VEGFA
9 activation of MAPK activity GO:0000187 9.9 FGF2 HGF TNF
10 cellular response to hypoxia GO:0071456 9.9 EDN1 HIF1A VEGFA
11 positive regulation of DNA binding transcription factor activity GO:0051091 9.89 EDN1 IL6 TNF
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 HGF IL6 VEGFA
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 IL6 TNF VEGFA
14 regulation of blood pressure GO:0008217 9.87 ACE EDN1 NOS3
15 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.87 KDR PGF VEGFA
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.87 HGF KDR TEK
17 vasculogenesis GO:0001570 9.85 KDR TNNI3 VEGFA
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 EDN1 IL6 TNF
19 positive regulation of MAP kinase activity GO:0043406 9.83 EDN1 FGF2 TNF VEGFA
20 positive regulation of cell adhesion GO:0045785 9.82 CXCL12 TNF VEGFA
21 positive regulation of cell division GO:0051781 9.82 FGF2 PGF VEGFA
22 response to hypoxia GO:0001666 9.8 ANGPT2 CXCL12 EDN1 HIF1A PGF TEK
23 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.78 FGF2 KDR VEGFA
24 positive regulation of endothelial cell migration GO:0010595 9.78 EDN1 KDR TEK VEGFA
25 blood vessel morphogenesis GO:0048514 9.76 ANGPT2 EDN1 HIF1A
26 animal organ regeneration GO:0031100 9.76 ANGPT2 CXCL12 HGF PGF
27 angiogenesis GO:0001525 9.76 ANGPT2 FGF2 HIF1A KDR NOS3 PGF
28 positive regulation of focal adhesion assembly GO:0051894 9.75 KDR TEK VEGFA
29 positive regulation of chemokine production GO:0032722 9.74 HIF1A IL6 TNF
30 positive chemotaxis GO:0050918 9.73 CXCL12 FGF2 HGF VEGFA
31 embryonic hemopoiesis GO:0035162 9.72 HIF1A KDR
32 cell migration involved in sprouting angiogenesis GO:0002042 9.72 FGF2 KDR VEGFA
33 positive regulation of blood vessel endothelial cell migration GO:0043536 9.72 FGF2 HIF1A KDR NOS3 VEGFA
34 heart contraction GO:0060047 9.71 ACE TNNI3
35 positive regulation of positive chemotaxis GO:0050927 9.71 KDR VEGFA
36 induction of positive chemotaxis GO:0050930 9.71 CXCL12 PGF VEGFA
37 neutrophil mediated immunity GO:0002446 9.7 ACE IL6
38 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
39 positive regulation of axon extension involved in axon guidance GO:0048842 9.68 CXCL12 VEGFA
40 positive regulation of receptor biosynthetic process GO:0010870 9.68 EDN1 HIF1A
41 positive regulation of mast cell chemotaxis GO:0060754 9.67 PGF VEGFA
42 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.67 EDN1 NOS3
43 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.66 HIF1A VEGFA
44 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.65 ACE VEGFA
45 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 KDR VEGFA
46 glomerulus vasculature development GO:0072012 9.63 ANGPT2 TEK
47 Tie signaling pathway GO:0048014 9.62 ANGPT2 TEK
48 positive regulation of chemokine-mediated signaling pathway GO:0070101 9.59 EDN1 HIF1A
49 positive regulation of endothelial cell proliferation GO:0001938 9.5 CXCL12 FGF2 HIF1A KDR PGF TEK
50 positive regulation of angiogenesis GO:0045766 9.28 ANGPT2 FGF2 HGF HIF1A KDR NOS3

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.67 FGF2 HGF KDR TEK
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.61 FGF2 HGF TEK
3 mitogen-activated protein kinase kinase binding GO:0031434 9.58 ACE KDR TEK
4 integrin binding GO:0005178 9.56 CXCL12 FGF2 KDR VWF
5 chemoattractant activity GO:0042056 9.46 CXCL12 FGF2 HGF VEGFA
6 cytokine activity GO:0005125 9.43 CXCL12 EDN1 FGF2 IL6 TNF VEGFA
7 vascular endothelial growth factor receptor binding GO:0005172 9.32 PGF VEGFA
8 growth factor activity GO:0008083 9.1 CXCL12 FGF2 HGF IL6 PGF VEGFA

Sources for Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
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71 TGDB
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74 UMLS via Orphanet
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