MCID: LMB062
MIFTS: 54

Limb Ischemia

Categories: Cardiovascular diseases

Aliases & Classifications for Limb Ischemia

MalaCards integrated aliases for Limb Ischemia:

Name: Limb Ischemia 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050852
UMLS 74 C2945695

Summaries for Limb Ischemia

Disease Ontology : 12 An ischemia that is characterized by low blood supply to tissues in the limb due to interruption in the arterial blood supply.

MalaCards based summary : Limb Ischemia is related to critical limb ischemia and ischemia. An important gene associated with Limb Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Aspirin and Iodine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and heart, and related phenotypes are cardiovascular system and cellular

Related Diseases for Limb Ischemia

Diseases related to Limb Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 critical limb ischemia 33.9 HGF IL6 TEK TNF VEGFA
2 ischemia 30.7 ACE CXCL12 EDN1 HIF1A NOS3 PLAT
3 diabetic foot ulcers 30.7 CCL2 IL6
4 endocarditis 30.4 IL6 PLAT TNF
5 vasculitis 30.3 CCL2 TNF VWF
6 peripheral artery disease 30.1 ACE CCL2 IL6 NOS3 VEGFA
7 intermittent claudication 30.1 ACE IL6 VEGFA VWF
8 end stage renal failure 30.1 ACE IL6 TNF
9 peripheral vascular disease 30.1 ACE IL6 PLAT VEGFA VWF
10 atherosclerosis susceptibility 30.0 CCL2 IL6 NOS3 TNF
11 pneumonia 29.9 CCL2 IL6 TNF
12 varicose veins 29.9 HIF1A VEGFA VWF
13 cardiogenic shock 29.8 IL6 PLAT TNF
14 purpura 29.8 IL6 TNF VWF
15 chronic kidney failure 29.7 ACE EDN1 IL6 NOS3
16 diabetes mellitus 29.7 ACE EDN1 IL6 NOS3 TNF VEGFA
17 kawasaki disease 29.7 CCL2 IL6 TNF
18 kidney disease 29.6 ACE CCL2 EDN1 IL6 NOS3
19 coronary artery anomaly 29.4 ACE EDN1 NOS3 PLAT
20 connective tissue disease 29.4 ACE EDN1 IL6 TNF
21 stroke, ischemic 29.3 ACE NOS3 PLAT VWF
22 acute myocardial infarction 29.1 ACE EDN1 PLAT VWF
23 dilated cardiomyopathy 29.0 ACE EDN1 IL6 NOS3 TNF
24 arteriosclerosis 29.0 ACE CCL2 EDN1 HGF IL6
25 pulmonary hypertension 28.5 ACE EDN1 HIF1A NOS3 PLAT VWF
26 arteries, anomalies of 28.4 ACE CCL2 EDN1 IL6 NOS3 PGF
27 vascular disease 28.1 ACE CCL2 EDN1 FGF2 IL6 NOS3
28 microvascular complications of diabetes 5 28.1 ACE FGF2 KDR NOS3 PGF TEK
29 myocardial infarction 27.0 ACE CCL2 CXCL12 EDN1 HIF1A IL6
30 patellar tendinitis 10.5 NOS3 VEGFA
31 kashin-beck disease 10.5 TNF VEGFA
32 juvenile ankylosing spondylitis 10.5 IL6 TNF
33 null-cell leukemia 10.5 IL6 TNF
34 autoimmune myocarditis 10.5 IL6 TNF
35 streptococcal toxic-shock syndrome 10.5 IL6 TNF
36 purulent labyrinthitis 10.5 CCL2 NOS3
37 pyogenic granuloma 10.5 TEK VEGFA
38 infiltrating angiolipoma 10.4 VEGFA VWF
39 diffuse meningeal melanocytosis 10.4 EDN1 HGF
40 scorpion envenomation 10.4 IL6 TNF
41 angiokeratoma circumscriptum 10.4 KDR VEGFA
42 gastrointestinal system disease 10.4 IL6 TNF VEGFA
43 endometriosis 10.4 CCL2 IL6 VEGFA
44 thrombosis 10.3
45 eales disease 10.3 IL6 TNF VEGFA
46 bacterial infectious disease 10.3 CCL2 IL6 TNF
47 intravascular papillary endothelial hyperplasia 10.3 HIF1A VEGFA
48 macular retinal edema 10.3 CCL2 IL6 VEGFA
49 rosacea 10.3 IL6 TNF VEGFA
50 kaposiform hemangioendothelioma 10.3 KDR VWF

Graphical network of the top 20 diseases related to Limb Ischemia:



Diseases related to Limb Ischemia

Symptoms & Phenotypes for Limb Ischemia

MGI Mouse Phenotypes related to Limb Ischemia:

47 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 ACE CXCL12 EDN1 FGF2 HGF HIF1A
2 cellular MP:0005384 10.32 CXCL12 FGF2 HGF HIF1A IL6 KDR
3 hematopoietic system MP:0005397 10.32 ACE CXCL12 FGF2 HGF HIF1A IL6
4 homeostasis/metabolism MP:0005376 10.31 ACE EDN1 FGF2 HIF1A IL6 KDR
5 growth/size/body region MP:0005378 10.3 ACE EDN1 HGF HIF1A IL6 KDR
6 mortality/aging MP:0010768 10.28 ACE CXCL12 EDN1 FGF2 HGF HIF1A
7 immune system MP:0005387 10.26 ACE CCL2 CXCL12 HIF1A IL6 KDR
8 digestive/alimentary MP:0005381 10.16 EDN1 HIF1A IL6 NOS3 PLAT TNF
9 embryo MP:0005380 10.15 EDN1 HGF HIF1A KDR PGF TEK
10 endocrine/exocrine gland MP:0005379 10.14 ACE EDN1 HIF1A IL6 NOS3 PLAT
11 muscle MP:0005369 10.14 CXCL12 EDN1 FGF2 HIF1A IL6 KDR
12 liver/biliary system MP:0005370 10.11 ACE CXCL12 HGF HIF1A IL6 KDR
13 nervous system MP:0003631 10.1 CXCL12 EDN1 FGF2 HIF1A IL6 KDR
14 craniofacial MP:0005382 10.04 EDN1 HIF1A KDR PLAT TNF VEGFA
15 neoplasm MP:0002006 9.91 ACE FGF2 HIF1A IL6 PGF TNF
16 reproductive system MP:0005389 9.86 ACE CXCL12 FGF2 IL6 NOS3 PLAT
17 respiratory system MP:0005388 9.76 HIF1A IL6 KDR NOS3 PGF PLAT
18 skeleton MP:0005390 9.61 EDN1 FGF2 HIF1A IL6 KDR NOS3
19 vision/eye MP:0005391 9.32 FGF2 HIF1A IL6 KDR NOS3 PGF

Drugs & Therapeutics for Limb Ischemia

Drugs for Limb Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 252)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable 50-78-2 2244
2
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Teicoplanin Approved, Investigational Phase 4 61036-62-2
5
Metronidazole Approved Phase 4 443-48-1 4173
6
Povidone Approved Phase 4 9003-39-8
7
Povidone-iodine Approved Phase 4 25655-41-8
8
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
9
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
10
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 33069-62-4 36314
11
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 9005-49-6 46507594 772
12
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 120202-66-6, 113665-84-2 60606
13
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2 73963-72-1 2754
14
Lenograstim Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 135968-09-1
15
Alprostadil Approved, Investigational Phase 4,Phase 2 745-65-3 5280723 149351
16
Menthol Approved Phase 4 2216-51-5 16666
17
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2 1177-87-3
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
19
Iloprost Approved, Investigational Phase 4 78919-13-8 6443959
20
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
21
Dalteparin Approved Phase 4,Phase 2,Not Applicable 9005-49-6
22
Defibrotide Approved, Investigational Phase 4 83712-60-1
23
Ramipril Approved Phase 4 87333-19-5 5362129
24
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 1401-55-4
25
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
26
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 32051
27
Febuxostat Approved Phase 4 144060-53-7 134018
28
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
29
carbamide peroxide Approved Phase 4 124-43-6
30
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
31
Insulin glargine Approved Phase 4 160337-95-1
32
Pseudoephedrine Approved Phase 4 90-82-4 7028
33
Norepinephrine Approved Phase 4 51-41-2 439260
34
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
35
Ephedrine Approved Phase 4 299-42-3 9294
36
Phenylephrine Approved Phase 4 59-42-7 6041
37
Calcium Approved, Nutraceutical Phase 4,Phase 2,Early Phase 1,Not Applicable 7440-70-2 271
38
Uric acid Investigational Phase 4 69-93-2 1175
39 Dermatologic Agents Phase 4
40 Nutrients Phase 4,Not Applicable
41 Disinfectants Phase 4
42 Antibiotics, Antitubercular Phase 4,Phase 2,Not Applicable
43 Amoxicillin-Potassium Clavulanate Combination Phase 4
44 Clindamycin palmitate Phase 4
45 Micronutrients Phase 4,Not Applicable
46 Gentamicins Phase 4
47 Antitubercular Agents Phase 4
48 Antiparasitic Agents Phase 4
49 Anti-Infective Agents, Local Phase 4,Not Applicable
50 Plasma Substitutes Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 515)
# Name Status NCT ID Phase Drugs
1 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II) Unknown status NCT01173094 Phase 4
2 Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I) Unknown status NCT01171703 Phase 4
3 Evaluation of the Use of ACOTEC Drug-Eluting Balloon Litos ® in Below-The-Knee Arteries to Treat Critical Limb Ischemia Unknown status NCT02563535 Phase 4
4 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
5 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
6 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
7 Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery Unknown status NCT02085551 Phase 4
8 Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) Completed NCT00906022 Phase 4
9 Non-Interventional Post Marketing Surveillance Study of Neovasculgen® in Patients With Chronic Lower Limb Ischemia Completed NCT02369809 Phase 4 Neovasculgen®
10 Drug Eluting Balloon in peripherAl inTErvention For Below The Knee Angioplasty Evaluation Completed NCT01558505 Phase 4
11 Cryoplasty CLIMB-registry Completed NCT00459888 Phase 4
12 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
13 Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV Completed NCT00596752 Phase 4 Alprostadil
14 DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions Completed NCT00637741 Phase 4
15 Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp) Completed NCT00300690 Phase 4
16 Efficacy Study of Iliac Stents to Treat TASC A-B-C-D Iliac Artery Lesions Completed NCT00764777 Phase 4
17 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
18 Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in Humans Completed NCT02117206 Phase 4 L-arginine (L-arginine Veyron);Nacl
19 Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease Completed NCT01983449 Phase 4 Dexamethasone Sodium Phosphate Injection, USP
20 AngioSeal Versus Radial Approach in Acute Coronary Syndrome Completed NCT01653587 Phase 4
21 Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery Completed NCT01427621 Phase 4
22 Instrumental Sealing of Arterial Puncture Site Closure Device Versus Manual Compression Trial Completed NCT01389375 Phase 4
23 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
24 Optimization of Treatment in Patients With Severe Peripheral Ischemia (Fontaine Stage IIb) Completed NCT01718288 Phase 4 iloprost;Standard Treatment (aspirin.....),
25 Clinical and Cost Effectiveness of ACE Inhibitor, Ramipril, in Intermittent Claudicants Completed NCT01037530 Phase 4 Ramipril
26 The Study to Compare SMART Nitinol Stent and Balloon Angioplasty Completed NCT00309595 Phase 4
27 The Study to Compare the Cordis SMART™ Stent System With the Bard® Luminexx™ Stent Completed NCT00235131 Phase 4
28 DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions Completed NCT01412463 Phase 4
29 Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study) Recruiting NCT02829151 Phase 4 Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) );Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel;Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
30 Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging Recruiting NCT02807779 Phase 4 Dexamethasone infusion
31 Lowering-hyperuricemia Treatment on Cardiovascular Outcomes in Peritoneal Dialysis Patients Recruiting NCT03200210 Phase 4 Febuxostat;Placebo
32 Evaluation of Early CRRT and Beta-blocker InTerventions in Patients With ECMO(ELITE) Recruiting NCT03549923 Phase 4 Esmolol;Standard care
33 The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial Recruiting NCT03668236 Phase 4 Isotonic crystalloids
34 Vascular Closure Device Versus Transradial Approach in Primary Percutaneous Coronary Intervention Active, not recruiting NCT02831166 Phase 4
35 Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia Terminated NCT00403780 Phase 4 pregabalin;placebo
36 Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia Terminated NCT00504088 Phase 4
37 Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty Terminated NCT01150617 Phase 4 Insulin glargine plus insulin analogues
38 Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients Terminated NCT02203630 Phase 4 Phenylephrine;Norepinephrine
39 Use Art-assist and Neupogen to Treat Chronic Limb Ischemia Withdrawn NCT02408991 Phase 4 Neupogen
40 Critical Limb Ischemia Rapid Delivery by SurgWerks-CLI Kit and VXP System Unknown status NCT02538978 Phase 3
41 Use of Indocyanine Green Angiography in Critical Limb Ischemia Unknown status NCT02820467 Phase 3
42 Autologous Bone Marrow-derived Mononuclear Cells for Therapeutic Arteriogenesis in Patients With Limb Ischemia Unknown status NCT00539266 Phase 2, Phase 3
43 VADOplex Critical Limb Ischemia Study Unknown status NCT02034539 Phase 2, Phase 3
44 Distal Venous Arterialisation of Ischemic Limb Unknown status NCT01211925 Phase 2, Phase 3 Aspirin
45 Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass Surgery Unknown status NCT01450722 Phase 3
46 Autologous Bone Marrow Stem Cell Transplantation for Critical, Limb-threatening Ischemia Unknown status NCT00434616 Phase 2, Phase 3
47 Pain and Music Therapy in Patients Suffering Arteritis Unknown status NCT01323504 Phase 3
48 Transfusion Requirements in Critically Ill Oncologic Patient Unknown status NCT01648946 Phase 3
49 NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study Unknown status NCT00358085 Phase 3
50 Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI Unknown status NCT03001960 Phase 3 Preloading before TAVI;Postloading after TAVI

Search NIH Clinical Center for Limb Ischemia

Genetic Tests for Limb Ischemia

Anatomical Context for Limb Ischemia

MalaCards organs/tissues related to Limb Ischemia:

42
Bone, Bone Marrow, Heart, Endothelial, Kidney, Lung, Brain

Publications for Limb Ischemia

Articles related to Limb Ischemia:

(show top 50) (show all 2473)
# Title Authors Year
1
Re: "Is There an Important Role for Anxiety and Depression in the Elderly Patient with Critical Limb Ischemia, Especially after Major Amputation?" ( 30926421 )
2019
2
Is There an Important Role for Anxiety and Depression in the Elderly Patients with Critical Limb Ischemia, Especially After Major Amputation? ( 30731224 )
2019
3
Upper extremity distal dual bypass enables arteriovenous fistula construction in a critical limb ischemia. ( 30788100 )
2019
4
Comparison of open and endovascular procedures in patients with critical limb ischemia on dialysis. ( 30922740 )
2019
5
A prognostic score for clinical success after revascularization of critical limb ischemia in hemodialysis patients. ( 30922745 )
2019
6
Cost-effectiveness of the treatments for critical limb ischemia in the elderly population. ( 30922757 )
2019
7
Effectiveness of umbilical cord mesenchymal stem cells in patients with critical limb ischemia. ( 30926157 )
2019
8
2016 JAPAN Critical Limb Ischemia Database (JCLIMB) Annual Report. ( 30931073 )
2019
9
Outcomes After Drug-Coated Balloon Treatment of Femoropopliteal Lesions in Patients With Critical Limb Ischemia: A Post Hoc Analysis From the IN.PACT Global Study. ( 30931726 )
2019
10
Cell therapy of critical limb ischemia-problems and prospects. ( 30969159 )
2019
11
One-year outcome of the everolimus eluting, balloon expandable Promus Element and Promus Element Plus stent in the treatment of below-the-knee lesions in patients with critical limb ischemia. ( 30994307 )
2019
12
Lower extremity critical limb ischemia: A review of clinical features and management. ( 31005554 )
2019
13
Critical limb ischemia in a patient with systemic lupus erythematosus: a case report. ( 31018871 )
2019
14
A network meta-analysis of randomized controlled trials comparing treatment modalities for infrapopliteal lesions in critical limb ischemia. ( 31075473 )
2019
15
The role of delirium and other risk factors on mortality in elderly patients with critical limb ischemia undergoing major lower limb amputation. ( 31077770 )
2019
16
Graft flow predictive equation in distal bypass grafting for critical limb ischemia. ( 31078341 )
2019
17
The Impact of Maternal Fructose Exposure on Angiogenic Activity of Endothelial Progenitor Cells and Blood Flow Recovery After Critical Limb Ischemia in Rat Offspring. ( 31100865 )
2019
18
Hyperbaric oxygen facilitates the effect of endothelial progenitor cell therapy on improving outcome of rat critical limb ischemia. ( 31105810 )
2019
19
Regarding: "Homemade Device to Facilitate Percutaneous Venous Arterialization in Patients With No-Option Critical Limb Ischemia". ( 31106690 )
2019
20
Impact of infection severity on clinical outcomes in critical limb ischemia with tissue loss after endovascular treatment. ( 29967952 )
2019
21
Comparison of the Cost of Drug-Eluting Stents versus Bare Metal Stents in the Treatment of Critical Limb Ischemia in the United States. ( 30092444 )
2019
22
Evaluation of the BASIL Survival Prediction Model in Patients Undergoing Infrapopliteal Interventions for Critical Limb Ischemia. ( 30099169 )
2019
23
Clinical Effects of Planned Endovascular Therapy for Critical Limb Ischemia Patients with Tissue Loss. ( 30135330 )
2019
24
Utility of indigo carmine angiography in patients with critical limb ischemia: Prospective multi-center intervention study (DIESEL-study). ( 30144339 )
2019
25
The impact of chronic kidney disease on lower extremity bypass outcomes in patients with critical limb ischemia. ( 30154013 )
2019
26
Functional prognosis of critical limb ischemia and efficacy of restoration of direct flow below the ankle. ( 30193553 )
2019
27
Safety and Effectiveness of Retrograde Arterial Access for Endovascular Treatment of Critical Limb Ischemia. ( 30217705 )
2019
28
Outcomes after Lower Extremity Revascularization for Treatment of Critical Limb Ischemia with Tissue Loss in Patients with Chronic Immune-Mediated Inflammatory Disease. ( 30217708 )
2019
29
Awareness of Scleroderma Peripheral Artery Disease Presenting With Critical Limb Ischemia in Elderly Patients. ( 30270312 )
2019
30
Objective Performance Goals for Surgical Treatment of Critical Limb Ischemia. ( 30287288 )
2019
31
A Comparison of Outcomes After Lower Extremity Bypass and Repeat Endovascular Intervention Following Failed Previous Endovascular Intervention for Critical Limb Ischemia. ( 30376723 )
2019
32
Alprostadil treatment of critical limb ischemia in hemodialysis patients : A retrospective single-center analysis. ( 30421286 )
2019
33
Urgent need to clarify the definition of chronic critical limb ischemia - a position paper from the European Society for Vascular Medicine. ( 30451092 )
2019
34
Endovascular Therapy Using Diluted Contrast Medium for Critical Limb Ischemia in a Patient with Chronic Kidney Disease. ( 30464136 )
2019
35
SCAI 2018 Think Tank Proceedings: "What skillsets are required of vascular interventional cardiologists in evaluating and managing critical limb ischemia (CLI)? What role should SCAI play in supporting interventional cardiologists in their CLI practices, individually and collectively?" ( 30489007 )
2019
36
Evaluation of Quiescent-Interval Single-Shot Magnetic Resonance Angiography in Diabetic Patients With Critical Limb Ischemia Undergoing Digital Subtraction Angiography: Comparison With Contrast-Enhanced Magnetic Resonance Angiography With Calf Compression at 3.0 Tesla. ( 30580695 )
2019
37
Peroneal bypass versus endovascular peroneal intervention for critical limb ischemia. ( 30580779 )
2019
38
Hybrid Foot Vein Arterialization in No-Option Patients With Critical Limb Ischemia: A Preliminary Report. ( 30591004 )
2019
39
Endovascular treatment of TransAtlantic Inter-Society Consensus II D femoropopliteal lesions in patients with critical limb ischemia. ( 30611581 )
2019
40
Six-Month Freedom From Amputation Rates and Quality of Life Following Tibial and Pedal Endovascular Revascularization for Critical Limb Ischemia. ( 30618346 )
2019
41
Predictors of responders to mononuclear stem cell-based therapeutic angiogenesis for no-option critical limb ischemia. ( 30635050 )
2019
42
Critical limb ischemia: Current and novel therapeutic strategies. ( 30637723 )
2019
43
Plasma NAP-2 levels are associated with critical limb ischemia in peripheral arterial disease patients. ( 30638058 )
2019
44
Management of Non-Reconstructable Critical Limb Ischemia. ( 30664225 )
2019
45
Multidisciplinary Care for Critical Limb Ischemia: Current Gaps and Opportunities for Improvement. ( 30706755 )
2019
46
Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-Derived Mononuclear Cells Implantation in Critical Limb Ischemia With Scleroderma - Subanalysis of the Long-Term Clinical Outcomes Survey. ( 30726805 )
2019
47
Risk factors for critical limb ischemia in patients undergoing femoral cannulation for venoarterial extracorporeal membrane oxygenation: Is distal limb perfusion a mandatory approach? ( 30736721 )
2019
48
Six-Month Angiographic and Clinical Outcomes of Therapeutic Ultrasound Pretreatment Associated With Plain Balloon Angioplasty for Below-the-Knee Lesions in Patients With Critical Limb Ischemia: A Prospective, Single-Center Pilot Study. ( 30741077 )
2019
49
Relation between serum cotinine levels and trophic lesions in patients with critical limb ischemia: a pilot study. ( 30741123 )
2019
50
Restenosis is associated with prothrombotic plasma fibrin clot characteristics in endovascularly treated patients with critical limb ischemia. ( 30762155 )
2019

Variations for Limb Ischemia

Expression for Limb Ischemia

Search GEO for disease gene expression data for Limb Ischemia.

Pathways for Limb Ischemia

Pathways related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 CXCL12 EDN1 FGF2 HGF HIF1A IL6
2
Show member pathways
14.03 CCL2 FGF2 HGF HIF1A IL6 NOS3
3
Show member pathways
13.87 CCL2 CXCL12 FGF2 HGF HIF1A IL6
4
Show member pathways
13.72 CXCL12 FGF2 HGF IL6 KDR NOS3
5
Show member pathways
13.68 CCL2 CXCL12 EDN1 HGF IL6 KDR
6
Show member pathways
13.57 CXCL12 FGF2 HGF IL6 KDR NOS3
7
Show member pathways
13.55 CCL2 CXCL12 FGF2 HGF IL6 KDR
8
Show member pathways
13.49 FGF2 HGF KDR TEK TNF VEGFA
9
Show member pathways
13.39 CCL2 FGF2 HGF HIF1A IL6 TEK
10
Show member pathways
13.39 CCL2 CXCL12 FGF2 HGF IL6 KDR
11
Show member pathways
13.34 CXCL12 FGF2 HGF IL6 KDR PGF
12
Show member pathways
13.31 CCL2 CXCL12 FGF2 HGF IL6 KDR
13
Show member pathways
13.3 HGF NOS3 PLAT TEK VEGFA VWF
14
Show member pathways
13.24 CXCL12 FGF2 HGF IL6 KDR NOS3
15
Show member pathways
13.09 CXCL12 FGF2 HGF IL6 KDR PGF
16
Show member pathways
13.05 ACE CCL2 CXCL12 FGF2 HGF HIF1A
17
Show member pathways
13.01 CCL2 CXCL12 FGF2 HIF1A IL6 TNF
18
Show member pathways
12.9 HGF KDR PGF VEGFA VWF
19 12.89 CXCL12 FGF2 HGF HIF1A IL6 PGF
20 12.8 FGF2 HGF KDR PGF TEK TNF
21
Show member pathways
12.79 FGF2 HGF IL6 KDR NOS3 PGF
22
Show member pathways
12.78 FGF2 HGF KDR PGF TEK VEGFA
23
Show member pathways
12.74 CXCL12 FGF2 HGF IL6 KDR PGF
24
Show member pathways
12.71 FGF2 HGF IL6 KDR VEGFA
25
Show member pathways
12.68 CCL2 CXCL12 KDR NOS3 VEGFA
26
Show member pathways
12.66 CCL2 FGF2 IL6 NOS3 TEK TNF
27
Show member pathways
12.58 KDR NOS3 TNF VEGFA
28
Show member pathways
12.44 CXCL12 FGF2 HGF IL6 KDR PGF
29
Show member pathways
12.42 CCL2 KDR NOS3 VEGFA
30
Show member pathways
12.41 KDR NOS3 PGF VEGFA
31
Show member pathways
12.36 CCL2 IL6 PLAT TNF
32 12.34 FGF2 HGF HIF1A KDR TNF VEGFA
33
Show member pathways
12.28 CXCL12 FGF2 HGF IL6 KDR PGF
34
Show member pathways
12.26 FGF2 KDR NOS3 VEGFA
35 12.21 HIF1A IL6 TNF VEGFA
36 12.14 FGF2 HGF IL6 KDR VEGFA
37
Show member pathways
12.09 CCL2 CXCL12 FGF2 HGF IL6 KDR
38 12.01 CCL2 EDN1 IL6 TNF
39 12.01 CCL2 EDN1 KDR NOS3 PLAT TNF
40
Show member pathways
11.96 IL6 NOS3 TNF
41 11.95 EDN1 HIF1A IL6 NOS3 TEK VEGFA
42
Show member pathways
11.93 HIF1A KDR NOS3 PGF VEGFA
43 11.93 CCL2 EDN1 IL6 NOS3 TNF VEGFA
44 11.87 CCL2 CXCL12 IL6 TEK TNF VEGFA
45 11.77 CXCL12 FGF2 HGF IL6 PGF
46 11.77 CXCL12 EDN1 HIF1A VEGFA
47 11.76 CCL2 FGF2 HGF HIF1A IL6 TNF
48 11.75 CCL2 IL6 TNF
49 11.71 FGF2 PLAT VEGFA
50
Show member pathways
11.7 IL6 TNF VEGFA

GO Terms for Limb Ischemia

Cellular components related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ACE CCL2 CXCL12 EDN1 FGF2 HGF
2 extracellular region GO:0005576 9.47 ACE CCL2 CXCL12 EDN1 FGF2 HGF
3 platelet alpha granule lumen GO:0031093 9.43 HGF VEGFA VWF
4 Weibel-Palade body GO:0033093 9.16 EDN1 VWF

Biological processes related to Limb Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.97 CXCL12 EDN1 HGF KDR VEGFA
2 MAPK cascade GO:0000165 9.97 CCL2 FGF2 HGF TEK TNF
3 positive regulation of protein kinase B signaling GO:0051897 9.96 FGF2 HGF TEK TNF
4 cytokine-mediated signaling pathway GO:0019221 9.95 CCL2 FGF2 HGF HIF1A IL6 TNF
5 negative regulation of gene expression GO:0010629 9.93 ACE EDN1 HIF1A KDR TNF VEGFA
6 positive regulation of protein phosphorylation GO:0001934 9.91 HGF KDR PGF TEK TNF VEGFA
7 regulation of signaling receptor activity GO:0010469 9.91 CCL2 CXCL12 EDN1 FGF2 HGF IL6
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 EDN1 IL6 TNF
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 HGF IL6 VEGFA
10 cell chemotaxis GO:0060326 9.9 CCL2 CXCL12 HGF
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 IL6 TNF VEGFA
12 cellular response to interleukin-1 GO:0071347 9.89 CCL2 EDN1 HIF1A
13 regulation of blood pressure GO:0008217 9.88 ACE EDN1 NOS3
14 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.88 KDR PGF VEGFA
15 humoral immune response GO:0006959 9.87 CCL2 IL6 TNF
16 response to hypoxia GO:0001666 9.87 CXCL12 EDN1 HIF1A PGF PLAT TEK
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 EDN1 IL6 TNF
18 positive regulation of cell adhesion GO:0045785 9.85 CXCL12 TNF VEGFA
19 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 HGF KDR TEK TNF
20 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.84 EDN1 FGF2 TNF
21 positive regulation of cell division GO:0051781 9.84 FGF2 PGF VEGFA
22 animal organ regeneration GO:0031100 9.83 CXCL12 HGF PGF
23 positive regulation of MAP kinase activity GO:0043406 9.83 EDN1 FGF2 TNF VEGFA
24 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.82 FGF2 KDR VEGFA
25 protein kinase B signaling GO:0043491 9.81 CCL2 KDR TNF
26 positive regulation of endothelial cell migration GO:0010595 9.81 EDN1 KDR TEK VEGFA
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 CCL2 NOS3 TNF
28 sprouting angiogenesis GO:0002040 9.8 PGF TEK VEGFA
29 positive regulation of focal adhesion assembly GO:0051894 9.78 KDR TEK VEGFA
30 positive chemotaxis GO:0050918 9.78 FGF2 HGF PGF VEGFA
31 cell migration involved in sprouting angiogenesis GO:0002042 9.77 FGF2 KDR VEGFA
32 positive regulation of blood vessel endothelial cell migration GO:0043536 9.77 FGF2 HIF1A KDR NOS3 VEGFA
33 positive regulation of chemokine production GO:0032722 9.76 HIF1A IL6 TNF
34 angiogenesis GO:0001525 9.76 CCL2 FGF2 HIF1A KDR NOS3 PGF
35 positive regulation of glial cell proliferation GO:0060252 9.73 IL6 TNF
36 embryonic hemopoiesis GO:0035162 9.73 HIF1A KDR
37 positive regulation of calcium ion import GO:0090280 9.73 CCL2 CXCL12
38 positive regulation of DNA biosynthetic process GO:2000573 9.73 FGF2 HGF
39 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 CCL2 KDR
40 vascular endothelial growth factor signaling pathway GO:0038084 9.73 KDR PGF VEGFA
41 positive regulation of positive chemotaxis GO:0050927 9.72 KDR VEGFA
42 negative regulation of lipid storage GO:0010888 9.71 IL6 TNF
43 neutrophil mediated immunity GO:0002446 9.71 ACE IL6
44 positive regulation of axon extension involved in axon guidance GO:0048842 9.71 CXCL12 VEGFA
45 positive regulation of receptor biosynthetic process GO:0010870 9.71 EDN1 HIF1A
46 induction of positive chemotaxis GO:0050930 9.71 CXCL12 PGF VEGFA
47 positive regulation of mast cell chemotaxis GO:0060754 9.69 PGF VEGFA
48 positive regulation of neuroinflammatory response GO:0150078 9.69 IL6 TNF
49 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.69 EDN1 NOS3
50 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.68 KDR VEGFA

Molecular functions related to Limb Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.56 CXCL12 FGF2 KDR VWF
2 chemoattractant activity GO:0042056 9.46 FGF2 HGF PGF VEGFA
3 growth factor activity GO:0008083 9.43 CXCL12 FGF2 HGF IL6 PGF VEGFA
4 protein tyrosine kinase activity GO:0004713 9.32 KDR TEK
5 cytokine activity GO:0005125 9.17 CCL2 CXCL12 EDN1 FGF2 IL6 TNF
6 protein binding GO:0005515 10.24 CCL2 CXCL12 EDN1 FGF2 HGF HIF1A

Sources for Limb Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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