MCID: LMB024
MIFTS: 41

Limbic Encephalitis

Categories: Cancer diseases, Immune diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Limbic Encephalitis

MalaCards integrated aliases for Limbic Encephalitis:

Name: Limbic Encephalitis 11 19 53 43 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:0080741
MeSH 43 D020363
UMLS 71 C0338430

Summaries for Limbic Encephalitis

GARD: 19 Limbic encephalitis represents a group of autoimmune conditions characterized by inflammation of the limbic system and other parts of the brain. The cardinal sign of Limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. The symptoms typically develop over a few weeks or months, but they may evolve over a few days. Limbic encephalitis is often associated with an underlying neoplasm (paraneoplastic Limbic encephalitis); however some cases never have a neoplasm identified (non-paraneoplastic Limbic encephalitis). Various tests including imaging studies, laboratory tests, and tests that measure the electrical activity of the brain (EEG) may be utilized to confirm a diagnosis.

MalaCards based summary: Limbic Encephalitis is related to encephalitis and temporal lobe epilepsy. An important gene associated with Limbic Encephalitis is AMPH (Amphiphysin), and among its related pathways/superpathways are Fragile X syndrome and One-carbon metabolism and related pathways. The drugs Immunologic Factors and Immunoglobulins, Intravenous have been mentioned in the context of this disorder. Affiliated tissues include medial temporal lobes, brain and temporal lobe, and related phenotypes are nervous system and growth/size/body region

Disease Ontology: 11 An encephalitis that is characterized by subacute onset of short-term memory deficits, seizures or psychiatric symptoms located in the medial temporal lobes.

Wikipedia: 75 Limbic encephalitis is a form of encephalitis, a disease characterized by inflammation of the brain.... more...

Related Diseases for Limbic Encephalitis

Diseases in the Limbic Encephalitis family:

Autoimmune Limbic Encephalitis

Diseases related to Limbic Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 444)
# Related Disease Score Top Affiliating Genes
1 encephalitis 32.1 PNMA2 LGI1 CNTNAP2 AMPH
2 temporal lobe epilepsy 31.2 LGI1 GRIN2B GAD2 GAD1
3 status epilepticus 31.1 LGI1 GRIN2B GRIA1
4 amnestic disorder 30.9 LGI1 GRIN2B GRIA1 GAD1 CNTNAP2 ADAM22
5 retrograde amnesia 30.9 LGI1 GRIN2B GRIA1
6 paraneoplastic cerebellar degeneration 30.7 ELAVL3 AMPH
7 viral encephalitis 30.7 PNMA2 LGI1 CNTNAP2 AMPH
8 hashimoto thyroiditis 30.5 TPO GAD2 GAD1 ENO1
9 psychotic disorder 30.4 GRIN2B GRIA1 GAD2 GAD1 CNTNAP2
10 epilepsy 30.3 LGI1 GSR GRIN2B GRIA1 GAD2 GAD1
11 anterograde amnesia 30.2 PNMA2 LGI1 GAD2 DPYSL5 CNTNAP2 AMPH
12 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 30.2 GAD2 GAD1
13 lambert-eaton myasthenic syndrome 30.0 SOX1 ELAVL3 AMPH
14 transient global amnesia 30.0 LGI1 CNTNAP2 AK5
15 dissociative amnesia 30.0 LGI1 CNTNAP2 AK5
16 epilepsy, familial temporal lobe, 1 30.0 LGI1 CNTNAP2 ADAM22
17 peripheral nervous system disease 29.9 LGI1 GAD2 DPYSL5 CNTNAP2 AMPH
18 anxiety 29.8 GRIN2B GRIA1 GAD2 GAD1
19 alcohol dependence 29.8 GSR GRIN2B GAD2 GAD1
20 demyelinating polyneuropathy 29.7 LGI1 IGLON5 CNTNAP2
21 attention deficit-hyperactivity disorder 29.6 GRIN2B GRIA1 GAD2 GAD1 CNTNAP2
22 speech and communication disorders 29.6 LGI1 GRIN2B CNTNAP2
23 movement disease 29.6 LGI1 IGLON5 GAD2 DPYSL5 CNTNAP2 AMPH
24 bipolar disorder 29.6 GRIN2B GRIA1 GAD2 GAD1 CNTNAP2
25 cerebellar disease 29.5 GAD2 GAD1 DPYSL5 CNTNAP2 AMPH
26 whipple disease 29.4 PNMA2 LGI1 IGLON5 DPYSL5 DPP6
27 acute disseminated encephalomyelitis 29.1 PNMA2 LGI1 IGLON5 DPYSL5 DPP6 CNTNAP2
28 stiff-person syndrome 29.0 PNMA2 LGI1 IGLON5 GAD2 GAD1 DPYSL5
29 nervous system disease 29.0 LGI1 GSR GRIN2B GRIA1 GAD2 GAD1
30 choreatic disease 28.6 PNMA2 LGI1 IGLON5 GRIN2B GAD2 DPYSL5
31 autoimmune epilepsy 28.3 SOX1 PNMA2 LGI1 IGLON5 GAD2 DPYSL5
32 posttransplant acute limbic encephalitis 11.6
33 nmda receptor encephalitis 11.6
34 autoimmune limbic encephalitis 11.4
35 limbic encephalitis with lgi1 antibodies 11.4
36 neuropathy, hereditary sensory and autonomic, type iia 11.2
37 autoimmune encephalitis 10.7
38 small cell cancer of the lung 10.7
39 teratoma 10.7
40 hypokalemia 10.7
41 visual epilepsy 10.7
42 thymoma 10.7
43 lung cancer 10.6
44 primary agammaglobulinemia 10.6
45 glioma susceptibility 1 10.6
46 teratoma, ovarian 10.6
47 glioma 10.6
48 glial tumor 10.6
49 lymphoma, hodgkin, classic 10.5
50 testicular cancer 10.5

Graphical network of the top 20 diseases related to Limbic Encephalitis:



Diseases related to Limbic Encephalitis

Symptoms & Phenotypes for Limbic Encephalitis

MGI Mouse Phenotypes related to Limbic Encephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.97 ADAM22 AMPH CNTNAP2 DPP6 DPYSL5 ELAVL3
2 growth/size/body region MP:0005378 9.77 ADAM22 CNTNAP2 ENO1 GAD1 GAD2 GRIA1
3 behavior/neurological MP:0005386 9.44 ADAM22 AMPH CNTNAP2 DPYSL5 ELAVL3 GAD1

Drugs & Therapeutics for Limbic Encephalitis

Drugs for Limbic Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Immunoglobulins, Intravenous Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2
5 Autoantibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 IVIG Treatment for Refractory Immune-Related Adult Epilepsy Terminated NCT01545518 Phase 2 IVIG

Search NIH Clinical Center for Limbic Encephalitis

Cochrane evidence based reviews: limbic encephalitis

Genetic Tests for Limbic Encephalitis

Anatomical Context for Limbic Encephalitis

Organs/tissues related to Limbic Encephalitis:

FMA: Medial Temporal Lobes
MalaCards : Brain, Temporal Lobe, Lung, Amygdala, Bone Marrow, Cingulate Cortex, Prostate

Publications for Limbic Encephalitis

Articles related to Limbic Encephalitis:

(show top 50) (show all 1600)
# Title Authors PMID Year
1
Antibodies and neuronal autoimmune disorders of the CNS. 53 62
20035430 2010
2
[Limbic encephalitis with antibodies against intracellular antigens]. 53 62
20420174 2010
3
Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. 53 62
20437582 2010
4
Plasma exchange for anti GAD associated non paraneoplastic limbic encephalitis. 53 62
18955013 2008
5
Antibodies to voltage-gated potassium and calcium channels in epilepsy. 53 62
16870397 2006
6
Early-Stage Contactin-Associated Protein-like 2 Limbic Encephalitis: Clues for Diagnosis. 62
36288995 2023
7
Subacute dementia revealing a limbic encephalitis with anti-GAD 65 antibodies in a young woman. 62
34562261 2022
8
18 F-Fluorodeoxy Glucose and 11 C-Methionine Accumulation in Demyelinating Lesions. 62
36398309 2022
9
Limbic encephalitis and subclinical hashimoto's disease associated with anti-GAD and anti-titin antibodies in a case of prostate cancer. 62
34264512 2022
10
Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions. 62
36259555 2022
11
Parallel roles of neuroinflammation in feline and human epilepsies. 62
36209994 2022
12
Anti-PD-L1 therapy-associated hypophysitis and limbic encephalitis. 62
36323910 2022
13
Guillain-Barré-like syndrome: an uncommon feature of CASPR2 and LGI1 autoimmunity. 62
35781606 2022
14
Immune-mediated diseases involving central and peripheral nervous systems. 62
36366904 2022
15
Rho GTPase-activating protein 10 (ARHGAP10/GRAF2) is a novel autoantibody target in patients with autoimmune encephalitis. 62
35624318 2022
16
Seizures in anti-Hu-associated extra-limbic encephalitis: Characterization of a unique disease manifestation. 62
36239616 2022
17
Fatal X-linked lymphoproliferative disease type 1-associated limbic encephalitis with positive anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody. 62
35778314 2022
18
Autoimmune neuromyotonia. 62
35989569 2022
19
Leucine-rich Glioma-inactivated 1 Encephalitis Followed by Isaacs Syndrome: Alternating Presence of Pathogenic Autoantibodies to Leucine-rich Glioma-inactivated 1 and Contactin-associated Protein-like 2. 62
36223927 2022
20
Neurological autoimmune diseases following vaccinations against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): A follow-up study. 62
36259114 2022
21
Autoimmune seronegative limbic encephalitis following ChAdOx1-S/nCoV-19 vaccination in a patient with ankylosing spondylitis. 62
36257910 2022
22
Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex. 62
36314080 2022
23
Cytokines/chemokines and soluble immune checkpoint molecules in anti-GABAB receptor encephalitis. 62
36270252 2022
24
Postvaccinal GABA-B receptor antibody encephalitis after ChAdOx1 nCoV-19 vaccination. 62
36053935 2022
25
MOG antibody-associated encephalitis in adult: clinical phenotypes and outcomes. 62
36261287 2022
26
Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes. 62
35512357 2022
27
Atezolizumab, vemurafenib, and cobimetinib in patients with melanoma with CNS metastases (TRICOTEL): a multicentre, open-label, single-arm, phase 2 study. 62
35940183 2022
28
Construction of an Assisted Model Based on Natural Language Processing for Automatic Early Diagnosis of Autoimmune Encephalitis. 62
35543808 2022
29
A reverse genetics and genomics approach to gene paralog function and disease: Myokymia and the juxtaparanode. 62
35948005 2022
30
Nonparaneoplastic Anti-GAD Limbic Encephalitis: Seizure Outcome and Long-term Neuropsychological Follow-up After Immunotherapy. 62
35856876 2022
31
Panhypopituitarism as the first sign of paraneoplastic limbic encephalitis in a patient with cured testicular cancer: a case report. 62
36175980 2022
32
Seronegative Autoimmune Limbic Encephalitis: A Case Report. 62
36082892 2022
33
Anti-flotillin-1/2 antibodies in a patient with neurogenic muscle atrophy and mild neuropsychological impairment. 62
36131297 2022
34
Neuropsychological and Structural Neuroimaging Outcomes in LGI1-Limbic Encephalitis: A Case Study. 62
36064192 2022
35
18F-FDG PET for the diagnosis and assessment of treatment response of autoimmune limbic encephalitis. 62
36150663 2022
36
18F-FDG-PET/MRI in Limbic Encephalitis. 62
36352635 2022
37
Post-COVID-19 Vaccine Limbic Encephalitis: A Case Report. 62
36249609 2022
38
Long-term evolution and prognostic factors of epilepsy in limbic encephalitis with LGI1 antibodies. 62
35595970 2022
39
Sexual behaviour change in seronegative limbic encephalitis due to the involvement of the left amygdala. 62
36280940 2022
40
Neurosyphilis presenting as autoimmune limbic encephalitis: A case report and literature review. 62
35984192 2022
41
Anti-Ma2-associated limbic encephalitis presenting with transient epileptic amnesia 62
35770767 2022
42
A Case Report of Wernicke's Encephalopathy Disguised As Limbic Encephalitis: A Clinical Puzzle. 62
36127954 2022
43
Persistent hiccup as one of the initial symptoms of leucine-rich glioma-inactivated-1 encephalitis: a case report. 62
35896991 2022
44
Mature Cystic Teratoma Combined With Autoimmune Limbic Encephalitis Mimicking Functional Ovarian Cyst. 62
35971364 2022
45
Early and aggressive treatment may modify anti Hu associated encephalitis prognosis. 62
35817357 2022
46
Two Cases of Limbic Encephalitis Successfully Treated With Electroconvulsive Therapy After Standard Immunomodulating Therapy Was Unsuccessful. 62
35900110 2022
47
Limbic encephalitis and Post-Acute neuropsychology rehabilitation: A review and case examples. 62
32776797 2022
48
Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. 62
35907972 2022
49
Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs: A Case Report. 62
35450924 2022
50
Distinct movement disorders in contactin-associated-protein-like-2 antibody associated autoimmune encephalitis. 62
35875984 2022

Variations for Limbic Encephalitis

Expression for Limbic Encephalitis

Search GEO for disease gene expression data for Limbic Encephalitis.

Pathways for Limbic Encephalitis

GO Terms for Limbic Encephalitis

Cellular components related to Limbic Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic density membrane GO:0098839 9.55 GRIN2B GRIA1 ADAM22
2 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 9.26 GAD2 GAD1
3 synapse GO:0045202 9.17 PPP1R9B LGI1 GRIN2B GRIA1 GAD2 GAD1

Biological processes related to Limbic Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.65 GRIN2B GRIA1 GAD2 GAD1 AMPH
2 neurotransmitter biosynthetic process GO:0042136 9.56 GAD2 GAD1
3 neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645 9.5 LGI1 ADAM22
4 gamma-aminobutyric acid biosynthetic process GO:0009449 9.46 GAD2 GAD1
5 glutamate decarboxylation to succinate GO:0006540 8.92 GAD2 GAD1

Molecular functions related to Limbic Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamate binding GO:0016595 9.56 GRIN2B GAD2
2 ionotropic glutamate receptor activity GO:0004970 9.32 GRIN2B GRIA1
3 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099507 9.16 GRIN2B GRIA1
4 carbon-carbon lyase activity GO:0016830 8.96 GAD2 GAD1
5 glutamate decarboxylase activity GO:0004351 8.92 GAD2 GAD1

Sources for Limbic Encephalitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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