Limited Scleroderma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LMT001 MIFTS: 47	Limited Scleroderma Categories: Bone diseases, Nephrological diseases, Rare diseases, Respiratory diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Limited Scleroderma

MalaCards integrated aliases for Limited Scleroderma:

Name: Limited Scleroderma ¹² ¹⁵ ¹⁷

Limited Cutaneous Systemic Sclerosis ¹² ²⁰ ⁵⁸

Systemic Sclerosis Sine Scleroderma ²⁰ ⁵⁸ ⁷¹

Limited Cutaneous Systemic Scleroderma ²⁰ ⁵⁸

Limited Systemic Sclerosis ²⁰ ⁵⁸

Scleroderma, Limited ⁴⁴ ⁷¹

Crest Syndrome ²⁰ ⁷¹

Progressive Systemic Sclerosis Sine Scleroderma ²⁰

Systemic Sclerosis, Limited ¹²

Scleroderma, Sine ²⁰

Characteristics:

Orphanet epidemiological data:

⁵⁸

limited cutaneous systemic sclerosis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: adult;

limited systemic sclerosis
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Nephrological diseases Respiratory diseases Bone diseases Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the musculoskeletal system and connective tissue

Systemic connective tissue disorders

Systemic sclerosis

CR(E)ST syndrome

Progressive systemic sclerosis

Orphanet: ⁵⁸

Rare renal diseases

Rare respiratory diseases

Rare systemic and rhumatological diseases

Rare skin diseases

External Ids:

Disease Ontology ¹² DOID:1577

MeSH ⁴⁴ D045745

SNOMED-CT ⁶⁷ 128459005

ICD10 via Orphanet ³³ M34.0 M34.1

Orphanet ⁵⁸ ORPHA220402 ORPHA220407

SNOMED-CT via HPO ⁶⁸ 11399002 16331000 16932000 more

EFO ¹⁷ EFO_1001017

UMLS ⁷¹ C0206138 C0748540 C1290138

Sources

Summaries for Limited Scleroderma

GARD : ²⁰ Limited cutaneous systemic sclerosis is a subtype of systemic sclerosis characterized by the association of Raynaud's phenomenon and skin fibrosis on the hands, face, feet and forearms. The exact cause of limited cutaneous systemic sclerosis is unknown, but likely originates from an autoimmune reaction which leads to overproduction of collagen. In some cases, the condition is associated with exposure to certain chemicals. Management is aimed at treating the symptoms present in each affected individual.

MalaCards based summary : Limited Scleroderma, also known as limited cutaneous systemic sclerosis, is related to scleroderma, familial progressive and telangiectasis. An important gene associated with Limited Scleroderma is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are IL12-mediated signaling events and Innate Lymphoid Cell Differentiation Pathways. The drugs Ropivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and endothelial, and related phenotypes are autoimmunity and hypopigmented skin patches

Sources

Related Diseases for Limited Scleroderma

Diseases related to Limited Scleroderma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 346)

#	Related Disease	Score	Top Affiliating Genes
1	scleroderma, familial progressive	31.2	TOP1 FBL CENPB CCN2
2	telangiectasis	31.1	TRIM21 TOP1 SNRNP70 FBL EXOSC10 CENPS
3	systemic scleroderma	31.0	TSSK1B TRIM21 TOP1 SNRNP70 IRF5 FBL
4	diffuse cutaneous systemic sclerosis	30.8	IRF5 HLA-DRB1 CCR6 CCN2 CAV1
5	primary biliary cholangitis	30.6	IRF5 HLA-DRB1 CENPB CCR6
6	myositis	30.6	TRIM21 IL2 HLA-DRB1 FBL
7	lupus erythematosus	30.6	TRIM21 SNRNP70 IRF5 HLA-DRB1
8	crest syndrome	30.6	TOP1 SNRNP70 FBL EXOSC10 CENPS CENPC
9	sarcoidosis 1	30.4	IL2RA IL2 HLA-DRB1 CCR6
10	collagen disease	30.4	TRIM21 SNRNP70 CCR6
11	gastric antral vascular ectasia	30.3	TOP1 CENPS
12	temporal arteritis	30.2	IL2 HLA-DRB1 CCR6
13	connective tissue disease	30.2	TOP1 SNRNP70 IL2 HLA-DRB1 FBL CENPC
14	diffuse scleroderma	30.2	TSSK1B TRIM21 TOP1 SNRNP70 FBL EXOSC10
15	juvenile rheumatoid arthritis	30.2	IL2RA IL2 HLA-DRB1
16	systemic lupus erythematosus	30.1	TRIM21 SNRNP70 KIAA0319L IRF5 IL2RA IL2
17	autoimmune disease	30.0	TRIM21 IRF5 IL2RA IL2 HLA-DRB1 FBL
18	raynaud disease	30.0	TRIM21 TOP1 SNRNP70 EXOSC10 CENPB CENPA
19	dyskinesia of esophagus	30.0	TSSK1B TRIM21 TOP1 SNRNP70 FBL EXOSC10
20	telangiectasia, hereditary hemorrhagic, type 4	11.2
21	conjunctival vascular disease	10.5	TRIM21 TOP1
22	recurrent respiratory papillomatosis	10.5	IL2 HLA-DRB1
23	tuberculoid leprosy	10.5	IL2RA IL2 CCR6
24	t-cell adult acute lymphocytic leukemia	10.5	IL2RA IL2 CCR6
25	subacute cutaneous lupus erythematosus	10.5	TRIM21 IRF5
26	red cell aplasia	10.5	IL2RA IL2 HLA-DRB1
27	pars planitis	10.5	IL2 HLA-DRB1 CCR6
28	refractory hairy cell leukemia	10.5	IL2RA HLA-DRB1
29	immunodeficiency 63 with lymphoproliferation and autoimmunity	10.5	IL2RA IL2
30	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	10.5	IL2RA IL2 CCR6
31	central nervous system vasculitis	10.5	IL2 HLA-DRB1 CCR6
32	pure red-cell aplasia	10.5	IL2RA IL2 HLA-DRB1
33	posterior uveitis	10.5	IL2RA IL2 CCR6
34	autoimmune gastritis	10.5	IL2 HLA-DRB1 CCR6
35	metal allergy	10.5	IL2 HLA-DRB1
36	facial hemiatrophy	10.4	SNRNP70 EXOSC10
37	herpes zoster	10.4	IL2 HLA-DRB1 CCR6
38	pulmonary sarcoidosis	10.4	IL2RA IL2 CCR6
39	exanthem	10.4	TRIM21 IL2 CCR6
40	lymph node disease	10.4	TRIM21 IL2 CCR6
41	salivary gland disease	10.4	TRIM21 IL2 CCR6
42	trochlear nerve disease	10.4	TRIM21 HLA-DRB1
43	intermediate uveitis	10.4	IL2RA IL2 HLA-DRB1 CCR6
44	adult t-cell leukemia	10.4	IL2RA IL2 CCR6
45	autoimmune disease of endocrine system	10.4	IL2RA IL2 HLA-DRB1 CCR6
46	leprosy 3	10.4	IL2 HLA-DRB1 CCR6
47	pulmonary arterial hypertension associated with congenital heart disease	10.4	CCN2 CAV1
48	cutaneous candidiasis	10.4	IL2RA CCR6
49	hypersensitivity reaction type iv disease	10.4	TRIM21 IL2 HLA-DRB1 CCR6
50	alopecia areata	10.4	IL2RA IL2 HLA-DRB1

Graphical network of the top 20 diseases related to Limited Scleroderma:

Sources

Symptoms & Phenotypes for Limited Scleroderma

Human phenotypes related to Limited Scleroderma:

⁵⁸ ³¹ (show all 15)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	autoimmunity ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002960
2	hypopigmented skin patches ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001053
3	narrow foramen obturatorium ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0100958
4	nausea and vomiting ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002017
5	dysphagia ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002015
6	gastroesophageal reflux ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0002020
7	skin ulcer ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0200042
8	mucosal telangiectasiae ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0100579
9	telangiectasia of the skin ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0100585
10	pulmonary fibrosis ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002206
11	pulmonary arterial hypertension ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002092
12	contractures involving the joints of the feet ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0008366
13	joint contracture of the hand ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0009473
14	abnormality of skin pigmentation ⁵⁸		Very frequent (99-80%)
15	abnormality of the skin ⁵⁸		Very frequent (99-80%)

Sources

Drugs & Therapeutics for Limited Scleroderma

Drugs for Limited Scleroderma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ropivacaine

Approved

Phase 4

84057-95-4

71273 175805

Synonyms:

(-)-1-Propyl-2',6'-dimethyl-2-piperidylcarboxyanilide

(-)-1-Propyl-2',6'-pipecoloxylidide

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride

(S)-(−)-1-propyl-2',6'-pipecoloxylidide

(S)-(-)-1-Propyl-2',6'-pipecoloxylidide

(S)-ropivacaine

1 Propyl 2',6' pipecoloxylidide

1-Propyl-2',6'-pipecoloxylidide

84057-95-4

98717-15-8

AC1L41QM

AC1L41QN

BIDD:GT0203

C07532

C17H26N2O.HCl

CHEBI:8890

CHEMBL1077896

CID175804

CID175805

CPD000469137

D08490

I14-176

LEA 103

LEA-103

L-N-N-Propylpipecolate-2,6-xylidide

L-N-n-propylpipecolic acid-2,6-xylidide

L-N-N-Propylpipecolic acid-2,6-xylidide

LS-113954

MLS001401363

MolPort-003-983-292

Naropeine

Naropin

Naropin (TN)

NCGC00164597-01

Ropivacaina

Ropivacaina [INN-Spanish]

Ropivacaina [Spanish]

Ropivacaine

Ropivacaine [INN]

ROPIVACAINE HCl

Ropivacaine hydrochloride

Ropivacaine monohydrochloride

ropivacaine monohydrochloride,

ropivacaine monohydrochloride, (S)-isomer

Ropivacaine monohydrochloride, (S)-isomer

Ropivacainum

Ropivacainum [INN-Latin]

SAM001246524

SMR000469137

S-Ropivacaine

ST51051452

Anesthetics

Phase 4

Anesthetics, Local

Phase 4

Sodium citrate

Approved, Investigational

Phase 3

68-04-2

Synonyms:

Anhydrous sodium citrate

Anhydrous trisodium citrate

Citric acid, trisodium salt

Natrii citras

Natrocitral

Sodium citrate anhydrous

Sodium citrate, anhydrous

Sodium citrate,anhydrous

trisodium citrate anhydrous

Trisodium citrate, anhydrous

Trisodium-citrate

Bupivacaine

Approved, Investigational

Phase 2, Phase 3

38396-39-3, 2180-92-9

2474

Synonyms:

( inverted exclamation markA)-bupivacaine

(+-)-Bupivacaine

(±)-bupivacaine

(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

(RS)-bupivacaine

15233-43-9

1-Butyl-2',6'-pipecoloxylidide

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

2180-92-9

38396-39-3

AB00053674

Abbott brand OF bupivacaine hydrochloride

AC1L1DRE

AC1Q5LX4

AC-2096

AH 250

AKOS001637202

Anekain

Anhydrous, bupivacaine

AR-1A0242

Astra brand OF bupivacaine hydrochloride

AstraZeneca brand OF bupivacaine hydrochloride

Aventis brand OF bupivacaine hydrochloride

Bio-0886

Bloqueina

BPBio1_000298

Braun brand OF bupivacaine hydrochloride

Braun, bupivacaina

BRD-A01636364-003-05-2

BSPBio_000270

BSPBio_002607

Bucaine

Bucaine (TN)

Bupivacain janapharm

Bupivacain RPR

Bupivacaina

Bupivacaina [INN-Spanish]

Bupivacaina braun

bupivacaine

Bupivacaine

Bupivacaine (INN)

Bupivacaine [INN:BAN]

Bupivacaine anhydrous

Bupivacaine carbonate

Bupivacaine Carbonate

Bupivacaine HCL

Bupivacaine HCL kit

Bupivacaine HCL KIT

Bupivacaine hydrochloride

Bupivacaine monohydrochloride, monohydrate

Bupivacaine Monohydrochloride, Monohydrate

Bupivacain-RPR

Bupivacainum

Bupivacainum [INN-Latin]

Bupivan

Buvacaina

C07529

C18H28N2O

Carbonate, bupivacaine

Carbostesin

cBupivacaine

CBupivacaine

CHEBI:3215

CHEMBL1098

CID2474

D07552

DB00297

DepoBupivacaine

DivK1c_000758

dl-1-Butyl-2',6'-pipecoloxylidide

DL-Bupivacaine

Dolanaest

DUR-843

EINECS 218-553-3

EINECS 253-911-2

Exparel

HMS2090F12

Hydrochloride, bupivacaine

IDI1_000758

Inibsa brand OF bupivacaine hydrochloride

Janapharm, bupivacain

Jenapharm brand OF bupivacaine hydrochloride

KBio1_000758

KBio2_002004

KBio2_004572

KBio2_007140

KBio3_001827

KBioGR_001516

KBioSS_002004

KST-1A4609

L000695

LAC-43

LS-109841

LS-2222

Marcain

Marcaina

Marcaine

Marcaine HCL

Marcaine Spinal

MLS001361336

MolPort-004-955-820

NCGC00178579-01

NCGC00178579-02

NINDS_000758

NSC119660

Pisa brand OF bupivacaine hydrochloride

Prestwick0_000305

Prestwick1_000305

Prestwick2_000305

Prestwick3_000305

Racemic bupivacaine

Sensorcaine

Sensorcaine-MPF

Sensorcaine-MPF Spinal

SMR000058218

SPBio_001558

SPBio_002489

Spectrum_001524

Spectrum2_001589

Spectrum3_000974

Spectrum4_001098

Spectrum5_001483

Strathmann brand OF bupivacaine hydrochloride

Svedocain sin vasoconstr

Transdur-Bupivacaine

UNII-Y8335394RO

Win 11318

Win 11318 HCl

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 3

77-92-9

311

Synonyms:

2-hydroxy-1,2,3-propanetricarboxyic acid

2-Hydroxy-1,2,3-propanetricarboxylate

2-Hydroxy-1,2,3-propanetricarboxylic acid

2-Hydroxytricarballylate

2-Hydroxytricarballylic acid

3-Carboxy-3-hydroxypentane-1,5-dioate

3-carboxy-3-hydroxypentane-1,5-dioic acid

3-Carboxy-3-hydroxypentane-1,5-dioic acid

Acid monohydrate, citric

ácido cítrico

Acidum citricum

Aciletten

Anhydrous citrate

Anhydrous citric acid

beta-Hydroxytricarballylate

beta-Hydroxytricarballylic acid

Chemfill

Citraclean

Citrate

Citrate anhydrous

Citretten

Citric acid anhydrous

Citric acid monoglyceride

Citric acid monohydrate

Citric acid, anhydrous

Citric acid,anhydrous

Citro

Citronensaeure

Citronensäure

e 330

e330

H3Cit

Hydrocerol a

Kyselina citronova

Monohydrate, citric acid

Suby g

Uralyt u

Uro-trainer

Citrate

Phase 3

Phosphodiesterase Inhibitors

Phase 3

Phosphodiesterase 5 Inhibitors

Phase 3

Sildenafil Citrate

Phase 3

171599-83-0

Anticoagulants

Phase 3

Calcium, Dietary

Phase 3

Chelating Agents

Phase 3

Vasodilator Agents

Phase 3

Calcium

Nutraceutical

Phase 3

7440-70-2

271

Synonyms:

Ca(2+)

Ca2+

Calcio

Calcium

Calcium element

CALCIUM ion

Calcium(2+)

Calcium, doubly charged positive ion

Calcium, elemental

Elemental calcium

Kalzium

Ifetroban

Investigational

Phase 2

143443-90-7

Platelet Aggregation Inhibitors

Phase 2

Racepinephrine

Approved

329-65-7

838

Synonyms:

(+-)-Adrenaline

(+-)-Epinephrine

2-(Methylamino)-1-(3,4-dihydroxyphenyl)ethanol

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

Bird brand OF racepinefrine hydrochloride

DL-Adrenaline

Epinephrine hydrochloride, racemic mixture

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Hydrochloride, racepinephrine

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Vaponefrin

Epinephrine

Approved, Vet_approved

51-43-4

5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-Adrenalin

(−)-adrenaline

(-)-Adrenaline

(-)-Epinephrine

(-)-R-Epinephrine

(R)-(-)-Adnephrine

(R)-(−)-adrenaline

(R)-(-)-Adrenaline

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

02252_FLUKA

1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

1-Adrenalin

1-Epinephrine

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

51028-73-0

51-43-4

51-43-4 (FREE BASE)

A0173

AC-13188

AC1L1L7B

Acetate, epinephrine

Adnephrine

ADR ADRENALINE

Adrenal

Adrenalin

Adrenalin (TN)

Adrenalin in Oil

Adrenalina

Adrenalina [DCIT]

adrenaline

Adrenaline

Adrénaline

Adrenaline (JP15)

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline/Epinephrine

Adrenalin-Medihaler

Adrenalinum

Adrenamine

Adrenan

Adrenapax

Adrenasol

Adrenatrate

Adrenine

Adrenodis

Adrenohorma

Adrenosan

Adrenutol

Adrin

Adrine

ADROP

AI3-19015

Allergan brand OF adrenaline hydrochloride

Ana-Guard

Ana-kit

Antiasthmatique

Asmatane Mist

Asthma meter mist

Asthmahaler Mist

Asthmanefrin

Asthma-nefrin

Astmahalin

Astminhal

Auvi-Q

Balmadren

Bernarenin

BIDD:GT0119

Biorenine

bmse000316

Bosmin

Brevirenin

Bronkaid

Bronkaid mist

Bronkaid Mist

Bronkaid Suspension Mist

Bupivacaine Hcl and Epinephrine

C00788

CCRIS 4812

CHEBI:28918

Chelafrin

CHEMBL679

CID5816

Citanest Forte

Corisol

D00095

d-Adrenaline

DB00668

D-Epifrin

D-Epinephrine

Drenamist

Dylephrin

Dyspne-Inhal

E4250_SIGMA

EINECS 200-098-7

EPI E Z PEN JR

Epi EZ Pen Jr

Epifrin

Epiglaufrin

Epinefrin

Epinefrin [Czech]

Epinefrina

Epinefrina [INN-Spanish]

Epinephran

Epinephrin

epinephrine

Epinephrine

Epinephrine (USP)

Epinephrine (USP/INN)

Epinephrine [USAN:INN:JAN]

Epinephrine acetate

Epinephrine bitartrate

Epinephrine hydrochloride

Epinephrine hydrogen tartrate

Epinephrinum

Epinephrinum [INN-Latin]

Epipen

Epipen (TN)

Epipen Auto-Injector

EPIPEN E Z PEN

Epipen EZ Pen

Epipen JR

EPIPEN JR

Epipen Jr.

Epipen Jr. Auto-Injector

Epirenamine

Epirenan

Epirenin

Epitrate

Eppy

Esphygmogenina

Exadrin

Glaucon

Glaucosan

Glauposine

Glycirenan

Haemostasin

Haemostatin

Hektalin

Hemisine

Hemostasin

Hemostatin

HSCI1_000215

HSDB 4289

Hypernephrin

Hyporenin

Intranefrin

Iontocaine

IOP

Isoptoepinal

Kidoline

l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

l-Adrenalin

l-Adrenaline

L-Adrenaline

L-Adrenaline Base

L-Epinehphrine

l-Epinephine

L-epinephrine

L-Epinephrine

l-Epinephrine (synthetic)

l-Epirenamine

L-Epirenamine

Levoadrenaline

Levoepinephrine

Levo-Methylaminoethanolcatechol

Levorenen

Levorenin

Levorenine

Levoreninum

l-Methylaminoethanolcatechol

L-Methylaminoethanolcatechol

Lopac-E-4642

LS-156

Lyodrin

Lyophrin

Medihaler-epi

Medihaler-Epi

Metanephrin

Methylaminoethanolcatechol

Methylarterenol

Micronefrin

Micronephrine

MolPort-002-051-368

Mucidrina

Myosthenine

Mytrate

NCGC00015417-01

NCGC00142615-01

NCGC00142615-03

NCGC00142615-04

NCGC00142615-05

NCGC00142615-06

NCGC00142615-07

nchembio747-comp9

Nephridine

Nieraline

NSC 62786

NSC62786

Paranephrin

PDSP1_001120

PDSP2_001104

Primatene

Primatene mist

Primatene Mist

R-(-)-Epinephrine

Racemic Epinephrine

Racepinephrine

R-Adrenaline

RCRA waste no. P042

Rcra waste number P042

Renagladin

Renaglandin

Renaglandulin

Renaleptine

Renalina

Renoform

Renostypricin

Renostypticin

Renostyptin

Scurenaline

Septocaine

Simplene

Sindrenina

SMP1_000227

Soladren

Sphygmogenin

ST069368

Stryptirenal

Styptirenal

Supracapsulin

Supradin

Supranefran

Supranephrane

Supranephrine

Supranol

Suprarenaline

Suprarenin

Suprel

Surenine

Surrenine

Susphrine

Sus-phrine

Sus-Phrine

SUS-PHRINE SULFITE-FREE

Sympathin I

Takamina

Takamine

Tokamina

Tonogen

Twinject

Twinject 0.15

Twinject 0.3

Twinject 0.30

UNII-YKH834O4BH

Vaponefrin

Vasoconstrictine

Vasoconstrictor

Vasodrine

Vasoton

Vasotonin

Nitric Oxide

Approved

10102-43-9

145068

Synonyms:

(.)NO

(NO)(.)

[NO]

10102-43-9

14332-28-6

295566_ALDRICH

51005-20-0

51005-21-1

53851-19-7

90452-29-2

AC1L1ADQ

AC1L3QHF

AC1Q6QZ0

AR-1K7463

Bioxyde d'azote

Bioxyde d'azote [French]

C00533

CCRIS 4319

CHEMBL1200689

CHEMBL1234765

CID145068

CID945

D00074

D009569

DB00435

EDRF

EINECS 233-271-0

Endogenous nitrate vasodilator

Endogenous Nitrate Vasodilator

Endothelium-derived nitric oxide

Endothelium-Derived Nitric Oxide

endothelium-derived relaxing factor

Endothelium-derived relaxing factor

HNO

HSDB 1246

INOmax

INOmax (TN)

LS-192158

LS-7547

MolPort-003-929-452

Mononitrogen monoxide

Monoxide, mononitrogen

Monoxide, Mononitrogen

Monoxide, nitrogen

Monoxide, Nitrogen

monoxido de nitrogeno

Monoxido de nitrogeno

Monóxido de nitrógeno

monoxyde d'azote

Monoxyde d'azote

Nitrate vasodilator, endogenous

Nitrate Vasodilator, Endogenous

nitric oxide

Nitric oxide

Nitric oxide (JAN)

Nitric oxide 10% by volume or more

Nitric oxide trimer

Nitric oxide, compressed [UN1660] [Poison gas]

Nitric oxide, endothelium derived

Nitric Oxide, Endothelium Derived

Nitric oxide, endothelium-derived

Nitric Oxide, Endothelium-Derived

NITRIC-OXIDE

nitrogen monooxide

Nitrogen monooxide

nitrogen monoxide

Nitrogen monoxide

Nitrogen oxide

Nitrogen oxide (NO)

Nitrogen protoxide

nitrosyl

Nitrosyl

Nitrosyl hydride

Nitrosyl hydride ((NO)H)

Nitrosyl radical

Nitroxide radical

Nitroxyl

NO(.)

OHM 11771

Oxide, nitric

Oxide, Nitric

oxido de nitrogeno(II)

Oxido de nitrogeno(II)

óxido de nitrógeno(II)

oxido nitrico

Oxido nitrico

óxido nítrico

oxidonitrogen(.)

oxoazanyl

oxyde azotique

Oxyde azotique

Oxyde nitrique

Oxyde nitrique [French]

RCRA waste no. P076

Stickmonoxyd

Stickmonoxyd [German]

Stickstoff(II)-oxid

Stickstoffmonoxid

UN 1660

UN1660

UNII-31C4KY9ESH

Vasodilator, endogenous nitrate

Vasodilator, Endogenous Nitrate

Pharmaceutical Solutions

Epinephryl borate

Analgesics

Analgesics, Opioid

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	Intérêt du TFP (Transversalis Fascia Plane) Bloc échoguidé Pour l'analgésie du prélèvement Osseux de crête Iliaque	Completed	NCT02398474	Phase 4	TFP block ropivacaine;ropivacaine infiltration of the iliac crest bone
2	Effect of Sildenafil on the Microcirculatory Blood Flow and on the Endothelial Progenitor Cells in Patients With Systemic Sclerosis: a Randomized, Double-blind, Placebo-controlled Clinical Trial	Completed	NCT01347008	Phase 3	Sildenafil citrate;Placebo (Sugar pill)
3	Chemical Sympathectomy Following Peripheral Nerve Block With Liposomal Bupivacaine	Terminated	NCT02374320	Phase 2, Phase 3	liposomal bupivacaine
4	A Phase 2 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of Ifetroban in Patients With Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension (SSc-PAH)	Recruiting	NCT02682511	Phase 2	Oral Ifetroban;Oral Placebo
5	Comparative Clinical Study of the Prevention of the Reduction of Alveolar Crest by Alveoli Filling With an Injectable Calcium Phosphate After Extraction of Mandibular Molar or Pre Molar	Unknown status	NCT00740311
6	A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma	Completed	NCT01881529
7	The Analgesic Efficacy of the Transversalis Fascia Plane Block in Iliac Crest Bone Graft Harvesting	Completed	NCT01133730		Active treatment;Placebo Arm
8	A Prospective Pilot Study on the Performance of The Plexur P™ Bone Void Filler	Completed	NCT00837473
9	Metabolomic Analysis of Systemic Sclerosis	Recruiting	NCT02298777
10	Localized Effects of Photobiomodulation and Exogenous Nitric Oxide on CREST Patients Calcinosis Cutis & Raynaud Phenomenon	Not yet recruiting	NCT03972566		INOMAX
11	A Multicenter, Prospective, Longitudinal Study to Evaluate Gastrointestinal Function and Clinical and Molecular Biomarkers in Subjects With Early and Late Diffuse Cutaneous Systemic Sclerosis, Limited Cutaneous Systemic Sclerosis, and Healthy Volunteers	Withdrawn	NCT02531009
12	Investigating Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease	Withdrawn	NCT04656704	Early Phase 1	hyaluronidase injected intradermally

Search NIH Clinical Center for Limited Scleroderma

Cochrane evidence based reviews: scleroderma, limited

Sources

Genetic Tests for Limited Scleroderma

Sources

Anatomical Context for Limited Scleroderma

MalaCards organs/tissues related to Limited Scleroderma:

⁴⁰

Bone, Skin, Endothelial, Thyroid, Breast, Smooth Muscle, T Cells

Sources

Publications for Limited Scleroderma

Articles related to Limited Scleroderma:

(show top 50) (show all 227)

#	Title	Authors	PMID	Year
1	Pauci-Immune Necrotizing Glomerulonephritis as a Manifestation of Systemic Sclerosis Sine Scleroderma. ⁶¹	Shabaka A...Rodriguez-Moreno A	31789998	2021
2	Systemic Sclerosis Sine Scleroderma After Silicone Breast Implants. ⁶¹	de Carvalho JF...Shoenfeld Y	33337809	2020
3	A 45-Year-Old Man with Scleroderma Renal Crisis Associated with a History of Systemic Sclerosis Sine Scleroderma. ⁶¹	Hansrivijit P...Dhatt RS	33230093	2020
4	A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath. ⁶¹	Walia A...Lutchmansingh DD	32654737	2020
5	Galectin-1 and Galectin-3 Expression in Lesional Skin of Patients With Systemic Sclerosis-Association With Disease Severity. ⁶¹	Mora GF...Zubieta MR	32501939	2020
6	Systemic Sclerosis Sine Scleroderma With Pulmonary Arterial Hypertension in a 3-Year-Old Girl. ⁶¹	Zloof Y...Harel L	32269136	2020
7	Pulmonary nodular and cystic light chain deposition disease: A retrospective review of 10 cases. ⁶¹	Baqir M...Ryu JH	32217287	2020
8	Sine Scleroderma. ⁶¹	Kaur G...Dhaka J	32610852	2020
9	Systemic Sclerosis Sine Scleroderma Manifested with Gastrointestinal Bleeding, Antiphospholipid Syndrome and Positive Anti-RNA Polymerase III Antibody: Case Report and Literature Review. ⁶¹	Alghamdi M...Derbes SJ	32801944	2020
10	Calcinosis Cutis as the Initial Manifestation of Limited Scleroderma. ⁶¹	Zalewski S...Zickuhr L	31985726	2020
11	Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-β1 secretion in abnormal scar formation. ⁶¹	Maeda D...Hosokawa K	31066603	2019
12	The evaluation of a home-based program for hands in patients with systemic sclerosis. ⁶¹	Landim SF...de Paiva Magalhaes E	29198478	2019
13	Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry. ⁶¹	Garcia-Hernandez FJ...Spanish Society of Internal Medicine (SEMI)	30535994	2019
14	Chronic Eroded Perianal Plaque in a Patient with Limited Systemic Scleroderma. ⁶¹	Velasco FG...Sluzevich JC	31782710	2019
15	Involvement of Periostin in Skin Function and the Pathogenesis of Skin Diseases. ⁶¹	Kuwatsuka Y...Murota H	31037628	2019
16	Connective Tissue Disease: Current Concepts. ⁶¹	Fernandez AP	30466687	2019
17	Comparing ultraviolet light A photo(chemo)therapy with Methotrexate protocol in childhood localized scleroderma: Evidence from systematic review and meta-analysis approach. ⁶¹	Marrani E...Simonini G	29655520	2018
18	Anti-RO 52-positive systemic sclerosis sine scleroderma with multisystem involvement and recurrent vasculitis. ⁶¹	Rao AG...Rani TS	30073982	2018
19	Improving life expectancy of patients with scleroderma: results from the South Australian Scleroderma Register. ⁶¹	Kennedy N...Roberts-Thomson P	29573101	2018
20	Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer. ⁶¹	Igusa T...Shah AA	29678941	2018
21	Systemic Sclerosis Sine Scleroderma in Mexican Patients. Case Reports. ⁶¹	Vera-Lastra O...Sepulceda-Delgado J	28065485	2018
22	[RHEOLOGICAL PROPERTIES OF BLOOD SERUM AT SYSTEMIC SCLEROSIS]. ⁶¹	Zabara A...Syniachenko O	29697389	2018
23	Assessing the response of morphea and limited scleroderma to tranilast: a small prospective study comparing topical corticosteroids to a combination of topical corticosteroids and tranilast. ⁶¹	Noakes R	30013378	2018
24	Periostin in the pathogenesis of skin diseases. ⁶¹	Murota H...Katayama I	28916993	2017
25	Cutaneous calcinosis in a patient with limited scleroderma: CREST Syndrome. ⁶¹	Duzgun N	29308290	2017
26	Upper gastrointestinal bleeding (watermelon stomach) in a patient with limited scleroderma (CREST syndrome). ⁶¹	Turrion Nieves AI...Perez Gomez A	27353193	2017
27	Choroidal and central foveal thickness in patients with scleroderma and its systemic associations. ⁶¹	Aydin E...Akar S	27864836	2017
28	[Research of systemic sclerosis sine scleroderma]. ⁶¹	Zhang GZ...Li HB	28870043	2017
29	Systemic sclerosis sine scleroderma. ⁶¹	Kucharz EJ...Kopec-Medrek M	29068586	2017
30	The Therapeutic Efficacy of Botulinum Toxin in Treating Scleroderma-Associated Raynaud's Phenomenon: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ⁶¹	Bello RJ...Lifchez SD	28426903	2017
31	Replacing a phosphodiesterase-5 inhibitor with riociguat in patients with connective tissue disease-associated pulmonary arterial hypertension: a case series. ⁶¹	Raina A...Farber HW	28671485	2017
32	Scleroderma Induced by Pembrolizumab: A Case Series. ⁶¹	Barbosa NS...Thanarajasingam U	28599746	2017
33	Anterior ST-elevation myocardial infarction induced by rituximab infusion: A case report and review of the literature. ⁶¹	Sharif K...Amital H	28440561	2017
34	Successful long-term (22 year) treatment of limited scleroderma using therapeutic plasma exchange: Is blood rheology the key? ⁶¹	Harris ES...Weiss J	27340761	2017
35	Survival protection by bodyweight in isolated scleroderma-related pulmonary artery hypertension. ⁶¹	Marini C...Giuntini C	27052360	2016
36	Comparison of the clinical utility of the Elia CTD Screen to indirect immunofluorescence on Hep-2 cells. ⁶¹	Robier C...Reicht G	26677892	2016
37	Anti-Interferon-Inducible Protein 16 Antibodies Associate With Digital Gangrene in Patients With Scleroderma. ⁶¹	McMahan ZH...Casciola-Rosen L	26714268	2016
38	Fibrillary glomerulonephritis associated with limited scleroderma: a case report. ⁶¹	Nakhoul GN...Simon JF	26709524	2016
39	Systemic sclerosis - a multi-purpose use of ultrasound: Editorial comment on: G. Pracoń, M. Płaza, M. Walentowska-Janowicz, I. Sudoł-Szopińska The value of ultrasound in the diagnosis of limited scleroderma - a case report. ⁶¹	Szkudlarek M	27104009	2016
40	Development of systemic sclerosis in patients with autoimmune hepatitis: an emerging overlap syndrome. ⁶¹	Assandri R...Montanelli A	27458514	2016
41	A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma. ⁶¹	Lee CM...Elwing JM	27559487	2016
42	Polymyositis and the Spectrum of Scleroderma Disorders. ⁶¹	Cochicho J...Carvalho A	30755854	2016
43	The value of ultrasound in the diagnosis of limited scleroderma - a case report. ⁶¹	Pracon G...Sudol-Szopinska I	26675049	2015
44	Pilot study to determine whether transient receptor potential melastatin type 8 (TRPM8) antibodies are detected in scleroderma. ⁶¹	Shah AA...Casciola-Rosen L	26242276	2015
45	Systemic sclerosis sine scleroderma: a case report of anterior uveitis. ⁶¹	Borges T...Dias C	26150271	2015
46	Multiple intracerebral hemorrhages in a patient with systemic sclerosis sine scleroderma. ⁶¹	Sarac H...Zarkovic K	24993862	2015
47	[Autoantibodies in systemic sclerosis and their clinical correlation in patients from a Midwestern region of Brazil]. ⁶¹	Coelho Horimoto AM...da Costa IP	25559063	2015
48	Osteonecrosis of multiple joints in a patient with limited scleroderma/CREST syndrome. ⁶¹	Desai K...Mian NZ	25807102	2015
49	[Usefulness of gastric emptying scintigraphy for the evaluation and management of scleroderma related gastroparesis]. ⁶¹	Piskorz MM...Olmos J	26076515	2015
50	Digital Ulcers, Systemic Sclerosis Sine Scleroderma and Paraneoplastic Phenomena Responding to Bosentan Therapy. ⁶¹	Sharabi I...Zandman-Goddard G	26223094	2015

Sources

Genes for Limited Scleroderma

Genes related to Limited Scleroderma (6 elite genes):

(show all 47)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	31.77	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵ ¹⁵
2	IRF5	Interferon Regulatory Factor 5	Protein Coding	29.9	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵
3	CCN2	Cellular Communication Network Factor 2	Protein Coding	29.38	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵
4	KIAA0319L	KIAA0319 Like	Protein Coding	29.13	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵
5	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	29.02	Susceptibility factor ⁵⁸ DISEASES inferred ¹⁵
6	CAV1	Caveolin 1	Protein Coding	25	Susceptibility factor ⁵⁸
7	CENPB	Centromere Protein B	Protein Coding	14.34	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	CENPC	Centromere Protein C	Protein Coding	13.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL2	Interleukin 2	Protein Coding	11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	6.91	GeneCards inferred via : Publications (show sections)
11	TOP1	DNA Topoisomerase I	Protein Coding	6.8	DISEASES inferred ¹⁵
12	EXOSC10	Exosome Component 10	Protein Coding	6.77	DISEASES inferred ¹⁵
13	CENPA	Centromere Protein A	Protein Coding	6.62	DISEASES inferred ¹⁵
14	SNRNP70	Small Nuclear Ribonucleoprotein U1 Subunit 70	Protein Coding	6.62	DISEASES inferred ¹⁵
15	CENPS	Centromere Protein S	Protein Coding	6.46	DISEASES inferred ¹⁵
16	TRIM21	Tripartite Motif Containing 21	Protein Coding	5.77	DISEASES inferred ¹⁵
17	SCRT2	Scratch Family Transcriptional Repressor 2	Protein Coding	5.72	DISEASES inferred ¹⁵
18	TSSK1B	Testis Specific Serine Kinase 1B	Protein Coding	5.72	DISEASES inferred ¹⁵
19	FBL	Fibrillarin	Protein Coding	5.61	DISEASES inferred ¹⁵
20	KRTAP17-1	Keratin Associated Protein 17-1	Protein Coding	5.6	DISEASES inferred ¹⁵
21	EDNRA	Endothelin Receptor Type A	Protein Coding	5.45	DISEASES inferred ¹⁵
22	EDN1	Endothelin 1	Protein Coding	5.45	DISEASES inferred ¹⁵
23	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	5.38	DISEASES inferred ¹⁵
24	UBTF	Upstream Binding Transcription Factor	Protein Coding	5.36	DISEASES inferred ¹⁵
25	ACE	Angiotensin I Converting Enzyme	Protein Coding	5.3	DISEASES inferred ¹⁵
26	PXK	PX Domain Containing Serine/Threonine Kinase Like	Protein Coding	5.3	DISEASES inferred ¹⁵
27	IFI16	Interferon Gamma Inducible Protein 16	Protein Coding	5.3	DISEASES inferred ¹⁵
28	RNPC3	RNA Binding Region (RNP1, RRM) Containing 3	Protein Coding	5.22	DISEASES inferred ¹⁵
29	BANK1	B Cell Scaffold Protein With Ankyrin Repeats 1	Protein Coding	5.17	DISEASES inferred ¹⁵
30	WDR11	WD Repeat Domain 11	Protein Coding	5.17	DISEASES inferred ¹⁵
31	RNU11	RNA, U11 Small Nuclear	RNA Gene	5.13	DISEASES inferred ¹⁵
32	ATRAID	All-Trans Retinoic Acid Induced Differentiation Factor	Protein Coding	5.1	DISEASES inferred ¹⁵
33	RNU12-2P	RNA, U12 Small Nuclear 2, Pseudogene	Pseudogene	4.87	DISEASES inferred ¹⁵
34	PDE5A	Phosphodiesterase 5A	Protein Coding	4.84	DISEASES inferred ¹⁵
35	CRP	C-Reactive Protein	Protein Coding	4.83	DISEASES inferred ¹⁵
36	MS4A4A	Membrane Spanning 4-Domains A4A	Protein Coding	4.82	DISEASES inferred ¹⁵
37	IFI44	Interferon Induced Protein 44	Protein Coding	4.8	DISEASES inferred ¹⁵
38	PRTN3	Proteinase 3	Protein Coding	4.77	DISEASES inferred ¹⁵
39	PYHIN1	Pyrin And HIN Domain Family Member 1	Protein Coding	4.76	DISEASES inferred ¹⁵
40	ASB10	Ankyrin Repeat And SOCS Box Containing 10	Protein Coding	4.76	DISEASES inferred ¹⁵
41	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	4.75	DISEASES inferred ¹⁵
42	HMGN2	High Mobility Group Nucleosomal Binding Domain 2	Protein Coding	4.74	DISEASES inferred ¹⁵
43	CHRNA9	Cholinergic Receptor Nicotinic Alpha 9 Subunit	Protein Coding	4.74	DISEASES inferred ¹⁵
44	OXCT1	3-Oxoacid CoA-Transferase 1	Protein Coding	4.7	DISEASES inferred ¹⁵
45	EXOSC9	Exosome Component 9	Protein Coding	4.69	DISEASES inferred ¹⁵
46	RO60	Ro60, Y RNA Binding Protein	Protein Coding	4.67	DISEASES inferred ¹⁵
47	FAM167A	Family With Sequence Similarity 167 Member A	Protein Coding	4.65	DISEASES inferred ¹⁵

Sources

Variations for Limited Scleroderma

Sources

Expression for Limited Scleroderma

Search GEO for disease gene expression data for Limited Scleroderma.

Sources

Pathways for Limited Scleroderma

Pathways related to Limited Scleroderma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	11.38	IL2RA IL2 HLA-DRB1
2	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.03	IL2RA IL2 CCR6
3	IL12 signaling mediated by STAT4 ¹	10.25	IL2RA IL2 HLA-DRB1

Sources

GO Terms for Limited Scleroderma

Cellular components related to Limited Scleroderma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromosome	GO:0005694	9.63	TOP1 FBL CENPS CENPC CENPB CENPA
2	chromosome, centromeric region	GO:0000775	9.56	CENPS CENPC CENPB CENPA
3	condensed chromosome kinetochore	GO:0000777	9.54	CENPS CENPC CENPA
4	condensed nuclear chromosome kinetochore	GO:0000778	9.32	CENPC CENPA
5	condensed chromosome, centromeric region	GO:0000779	9.13	CENPC CENPB CENPA
6	pericentric heterochromatin	GO:0005721	8.8	CENPC CENPB CENPA

Biological processes related to Limited Scleroderma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	interferon-gamma-mediated signaling pathway	GO:0060333	9.5	TRIM21 IRF5 HLA-DRB1
2	regulation of regulatory T cell differentiation	GO:0045589	9.43	IL2RA IL2
3	positive regulation of viral entry into host cell	GO:0046598	9.4	TRIM21 HLA-DRB1
4	interleukin-2-mediated signaling pathway	GO:0038110	9.37	IL2RA IL2
5	CENP-A containing nucleosome assembly	GO:0034080	9.33	CENPS CENPC CENPA
6	negative regulation of lymphocyte proliferation	GO:0050672	9.26	IL2RA IL2
7	regulation of T cell homeostatic proliferation	GO:0046013	8.96	IL2RA IL2
8	kinetochore assembly	GO:0051382	8.8	CENPS CENPC CENPA

Molecular functions related to Limited Scleroderma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	centromeric DNA binding	GO:0019237	8.62	CENPC CENPB

Sources

Sources for Limited Scleroderma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia