MCID: LNT001
MIFTS: 35

Linitis Plastica

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Linitis Plastica

MalaCards integrated aliases for Linitis Plastica:

Name: Linitis Plastica 12 45 15 74
Leather-Bottle Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4023
MeSH 45 D008039
NCIt 51 C3190
SNOMED-CT 69 37995004
UMLS 74 C0023743

Summaries for Linitis Plastica

MalaCards based summary : Linitis Plastica, also known as leather-bottle stomach, is related to gastric diffuse adenocarcinoma and signet ring cell adenocarcinoma. An important gene associated with Linitis Plastica is PRSS1 (Serine Protease 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cytoskeletal Signaling. The drugs Cisplatin and s 1 (combination) have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and prostate.

Wikipedia : 77 Linitis plastica, has become the widely used term for Brinton''s disease or leather bottle stomach,... more...

Related Diseases for Linitis Plastica

Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 gastric diffuse adenocarcinoma 31.1 KRT20 KRT7 MMP15 RAB11B
2 signet ring cell adenocarcinoma 30.3 KRT20 KRT7
3 small cell carcinoma 30.2 KRT20 KRT7
4 mammary paget's disease 30.0 KRT20 KRT7
5 intrahepatic cholangiocarcinoma 29.9 KRT20 KRT7
6 transitional cell carcinoma 29.8 KRT20 KRT7
7 gastric linitis plastica 12.6
8 breast cancer 10.7
9 adenocarcinoma 10.6
10 gastric cancer 10.6
11 bladder cancer 10.4
12 colitis 10.4
13 gastric adenocarcinoma 10.4
14 ulcerative colitis 10.4
15 lymphoma 10.4
16 gastritis 10.4
17 degos 'en cocarde' erythrokeratoderma 10.4
18 prostate cancer 10.3
19 sarcoma 10.3
20 syphilis 10.3
21 tropical calcific pancreatitis 10.2 PRSS1 PRSS2
22 pancreatitis 10.2 PRSS1 PRSS2
23 leukemia, chronic lymphocytic 2 10.1
24 leukemia, chronic lymphocytic 10.1
25 ovarian cancer 10.1
26 pernicious anemia 10.1
27 lymphoma, hodgkin, classic 10.1
28 myeloma, multiple 10.1
29 pancreatic cancer 10.1
30 prostate cancer, hereditary, 8 10.1
31 lymphoma, non-hodgkin, familial 10.1
32 gastrointestinal stromal tumor 10.1
33 ovarian cancer 1 10.1
34 hepatitis c virus 10.1
35 prostate cancer, hereditary, 6 10.1
36 leptin deficiency or dysfunction 10.1
37 cholangiocarcinoma 10.1
38 crohn's disease 10.1
39 hepatitis 10.1
40 leukemia 10.1
41 crohn's colitis 10.1
42 dermatomyositis 10.1
43 lymphocytic leukemia 10.1
44 gastric lymphoma 10.1
45 microinvasive gastric cancer 10.1
46 disseminated intravascular coagulation 10.1
47 hepatitis c 10.1
48 macrocytic anemia 10.1
49 breast ductal carcinoma 10.1
50 gallbladder signet ring cell adenocarcinoma 10.1

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to Linitis Plastica

Symptoms & Phenotypes for Linitis Plastica

Drugs & Therapeutics for Linitis Plastica

Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
2
s 1 (combination) Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric Cancer Completed NCT00252161 Phase 3 Neoadjuvant chemotherapy(TS-1+CDDP) followed by gastrectomy
2 A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma Patients Completed NCT01576380 Phase 2 TKI258

Search NIH Clinical Center for Linitis Plastica

Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

MalaCards organs/tissues related to Linitis Plastica:

42
Colon, Breast, Prostate, Appendix, Lung, Kidney, Thymus

Publications for Linitis Plastica

Articles related to Linitis Plastica:

(show top 50) (show all 216)
# Title Authors Year
1
Endoscopic ultrasound-guided fine-needle aspiration used in diagnosing gastric linitis plastica: Metastatic lymph nodes can be valuable targets. ( 29864202 )
2019
2
Linitis plastica: 'leather bottle' stomach. ( 30295839 )
2019
3
Linitis plastica of the colon due to metastases of invasive lobular breast carcinoma. ( 30859840 )
2019
4
A rare case of linitis plastica of the colon from ovarian carcinoma. ( 30949339 )
2019
5
Cholangiocarcinoma Presenting as Linitis Plastica with Unusual Metastases to the Psoas Muscle and Urinary Bladder. ( 30038923 )
2018
6
Personalized therapy based on sequential molecular analysis leads to 30 months of survival in a patient with diffuse unresectable gastric linitis plastica. ( 29714649 )
2018
7
Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review. ( 30073103 )
2018
8
Endoscopic ultrasound-guided fine-needle aspiration biopsy for diagnosis of gastric linitis plastica with negative malignant endoscopy biopsies. ( 30250557 )
2018
9
Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study. ( 30288113 )
2018
10
Primary Gastric Small Cell Carcinoma (Presenting as Linitis Plastica) Diagnosed Using Endoscopic Ultrasound-Guided Biopsy: A Case Report. ( 30300982 )
2018
11
Linitis plastica in excluded stomach after Roux-en-Y gastric bypass. ( 29634913 )
2018
12
IgM- Kappa type multiple myeloma with simultaneous gastro-esophageal involvement simulating linitis plastica. ( 29747781 )
2018
13
Computed tomography and magnetic resonance imaging findings of metastatic rectal linitis plastica from prostate cancer: A case report and review of literature. ( 30397613 )
2018
14
Gastric Metastasis Mimicking Linitis Plastica 20 Years after Primary Breast Cancer. A Case Report. ( 30574631 )
2018
15
Acute inflammation of the stomach mimicking linitis plastica. ( 30701166 )
2018
16
The "leather bottle" stomach. ( 29260279 )
2018
17
Dermatomyositis revealing both a metastatic linitis plastica and hepatitis C virus infection. ( 28731019 )
2017
18
Survival following operative management of gastric linitis plastica compared with non-operative management. ( 27809576 )
2017
19
A case report of gastric linitis plastica diagnosed by endoscopic ultrasound-guided fine needle aspiration. ( 29390283 )
2017
20
Linitis plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass: a case report. ( 27397038 )
2017
21
Urothelial Carcinoma of the Ureter and Urinary Bladder With Rectal Linitis Plastica. ( 28153589 )
2017
22
Clinical Outcomes after Surgery for Linitis Plastica of the Stomach: Analysis of a Population Cancer Registry. ( 28234115 )
2017
23
Image Diagnosis: A Gastric Signet-Ring Adenocarcinoma of Type Linitis Plastica Mimicking Splenomegaly in a Patient with Chronic Lymphocytic Leukemia. ( 28609263 )
2017
24
The significance of a nineteenth century definition in the era of genomics: linitis plastica. ( 28679451 )
2017
25
Linitis Plastica of Muscle Fascia Presenting as Tiptoeing Gait. ( 28809600 )
2017
26
Incomplete resection and linitis plastica are factors for poor survival after extended multiorgan resection in gastric cancer patients. ( 29150634 )
2017
27
Linitis plastica: a harbinger of an unusual cause of gastric wall thickening. ( 29905314 )
2017
28
Advanced gastric cancer linitis plastica presented with disseminated intravascular coagulation. ( 27803086 )
2016
29
An Unusual Cause of Gastric Linitis Plastica. ( 27810370 )
2016
30
Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging. ( 26814502 )
2016
31
Metastatic pancreatic cancer presenting as linitis plastica of the stomach. ( 26957034 )
2016
32
Jackhammer oesophagus in a case of linitis plastica. ( 27174454 )
2016
33
Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient. ( 27721883 )
2016
34
Linitis plastica like primary signet ring cell carcinoma of the gallbladder - an extremely rare variant. ( 28195258 )
2016
35
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. ( 24982453 )
2016
36
Is Linitis Plastica a Contraindication for Surgical Resection: A Multi-Institution Study of the U.S. Gastric Cancer Collaborative. ( 26530447 )
2016
37
Characteristic waffle-like appearance of gastric linitis plastica: A case report. ( 25435971 )
2015
38
Submucosal Endoscopic Sampling for Indefinite Gastric Linitis Plastica Infiltrating into the Submucosal Layer. ( 26405710 )
2015
39
Gastric Crohns presenting as linitis plastica. ( 26710492 )
2015
40
Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report. ( 26788154 )
2015
41
Primary linitis plastica of the rectum. ( 26895130 )
2015
42
Primary linitis plastica of the entire colon in a background of ulcerative colitis: a case report. ( 25649787 )
2015
43
Recurrent bladder cancer presenting as rectal linitis plastica. ( 25734804 )
2015
44
Endoscopic ultrasound of isolated gastric corrosive stricture mimicking linitis plastica. ( 25789288 )
2015
45
Primary Linitis Plastica of the Rectum: Focus on Magnetic Resonance Imaging Patterns and Treatment Options. ( 26322720 )
2015
46
Linitis plastica presenting two years after elective Roux-en-Y gastric bypass for treatment of morbid obesity: a case report and review of the literature. ( 24060402 )
2014
47
Gastric lymphocytic phlebitis as a differential diagnosis of linitis plastica. ( 24896765 )
2014
48
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the staging of linitis plastica caused by primary gastric adenocarcinoma. ( 25125999 )
2013
49
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. ( 23984032 )
2013
50
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. ( 24009205 )
2013

Variations for Linitis Plastica

Expression for Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for Linitis Plastica

Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 MMP15 PRSS1 PRSS2
2 11.62 KRT20 KRT7 RAB11B
3 11.25 PRSS1 PRSS2
4
Show member pathways
10.79 MMP15 PRSS1 PRSS2

GO Terms for Linitis Plastica

Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.26 KRT20 KRT7
2 collagen catabolic process GO:0030574 9.16 MMP15 PRSS2
3 digestion GO:0007586 8.96 PRSS1 PRSS2
4 extracellular matrix disassembly GO:0022617 8.8 MMP15 PRSS1 PRSS2

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 8.8 MMP15 PRSS1 PRSS2
2 metalloendopeptidase activity GO:0004222 8.65 MMP15

Sources for Linitis Plastica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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