MCID: LNT001
MIFTS: 29

Linitis Plastica

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Linitis Plastica

MalaCards integrated aliases for Linitis Plastica:

Name: Linitis Plastica 12 44 15 70
Leather-Bottle Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4023
MeSH 44 D008039
NCIt 50 C3190
SNOMED-CT 67 307594007
UMLS 70 C0023743

Summaries for Linitis Plastica

MalaCards based summary : Linitis Plastica, also known as leather-bottle stomach, is related to gallbladder signet ring cell adenocarcinoma and gastric signet ring cell adenocarcinoma. An important gene associated with Linitis Plastica is PRSS1 (Serine Protease 1), and among its related pathways/superpathways is Gastric cancer. Affiliated tissues include breast, colon and appendix.

Wikipedia : 73 Linitis plastica is a widely used term for Brinton's disease (also known as leather bottle stomach), a... more...

Related Diseases for Linitis Plastica

Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 409)
# Related Disease Score Top Affiliating Genes
1 gallbladder signet ring cell adenocarcinoma 30.6 KRT7 CDH1
2 gastric signet ring cell adenocarcinoma 30.5 PIP KRT7 CDX2
3 gastric adenocarcinoma 30.3 KRT20 ERBB2 CEACAM5 CDX2 CDH1
4 small cell carcinoma 30.2 KRT7 KRT20 ERBB2
5 microinvasive gastric cancer 30.1 ERBB2 CEACAM5 CDX2 CDH1
6 intestinal obstruction 30.0 KRT7 KRT20 CEACAM5 CDX2
7 transitional cell carcinoma 29.9 KRT7 KRT20 ERBB2 CDH1
8 signet ring cell adenocarcinoma 29.9 PIP KRT7 KRT20 ERBB2 CEACAM5 CDX2
9 breast adenocarcinoma 29.8 PIP PGR KRT7 ERBB2
10 breast ductal carcinoma 29.8 PIP PGR KRT7 ERBB2 CDH1
11 adenocarcinoma 29.6 KRT7 KRT20 ERBB2 CEACAM5 CDX2 CDH1
12 intrahepatic cholangiocarcinoma 29.6 KRT7 KRT20 ERBB2 CDX2 CDH1
13 mammary paget's disease 29.6 PIP PGR KRT7 KRT20 ERBB2
14 cholangiocarcinoma 29.2 KRT7 KRT20 ERBB2 CEACAM5 CDX2 CDH1
15 pancreatic cancer 28.9 PRSS1 KRT7 KRT20 ERBB2 CEACAM5 CDX2
16 endometrial cancer 28.7 PGR KRT7 KRT20 ERBB2 CEACAM5 CDX2
17 gastric diffuse adenocarcinoma 27.3 SCN10A PIP PGR KRT7 KRT20 ERBB2
18 gastric linitis plastica 11.5
19 gastric cancer 10.5
20 dysphagia 10.4
21 rare tumor 10.4
22 rectum cancer 10.4
23 constipation 10.4
24 gastritis 10.4
25 peritonitis 10.4
26 ceruminoma 10.3 PIP KRT7
27 ceruminous adenocarcinoma 10.3 PIP KRT7
28 bile duct adenoma 10.3 KRT7 KRT20
29 bladder cancer 10.3
30 colitis 10.3
31 diffuse gastric cancer 10.3
32 syphilis 10.3
33 ulcerative colitis 10.3
34 erysipeloid 10.3 PIP KRT7
35 bladder benign neoplasm 10.3 KRT7 KRT20
36 nephrogenic adenoma of urinary bladder 10.3 KRT7 KRT20
37 atrophic vulva 10.3 KRT7 KRT20
38 nipples, supernumerary 10.3 PIP KRT20
39 dacryocystocele 10.3 PIP KRT7
40 chronic inflammation of lacrimal passage 10.3 PIP KRT7
41 tinea cruris 10.3 PIP KRT7
42 lung acinar adenocarcinoma 10.3 PIP KRT20
43 urinary bladder small cell neuroendocrine carcinoma 10.3 KRT7 KRT20
44 tropical calcific pancreatitis 10.3 PRSS2 PRSS1
45 jejunal neoplasm 10.3 KRT7 KRT20
46 intratubular embryonal carcinoma 10.3 KRT7 KRT20
47 ovarian large-cell neuroendocrine carcinoma 10.3 KRT7 KRT20
48 papillary transitional carcinoma 10.3 KRT7 KRT20
49 supine hypotensive syndrome 10.3 KRT7 KRT20
50 meibomian cyst 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to Linitis Plastica

Symptoms & Phenotypes for Linitis Plastica

Drugs & Therapeutics for Linitis Plastica

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Single-arm, Multi-center, Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Adult Patients With Advanced Scirrhous Gastric Carcinoma That Have Progressed After One or Two Prior Systemic Treatments Completed NCT01576380 Phase 2 TKI258

Search NIH Clinical Center for Linitis Plastica

Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

MalaCards organs/tissues related to Linitis Plastica:

40
Breast, Colon, Appendix, Skin, Liver, Lung, Ovary

Publications for Linitis Plastica

Articles related to Linitis Plastica:

(show top 50) (show all 519)
# Title Authors PMID Year
1
Gastric linitis plastica due to signet-ring cell carcinoma with Krukenberg tumors diagnosed by endoscopic ultrasound-guided fine-needle aspiration. 61
33740238 2021
2
Gastric metastases from invasive lobular carcinoma of the breast: Case report. 61
33318776 2021
3
Endoscopic ultrasound efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study. 61
33553343 2021
4
Gastrointestinal: Franseen-tip transmural fine-needle biopsy for localized gastric linitis plastica. 61
33305373 2020
5
A Unique Case of Alpha-Fetoprotein-Negative Hepatoid Adenocarcinoma of the Stomach With Associated Signet Ring Cell Histological Features and Linitis Plastica. 61
33415058 2020
6
Cancer cells invasion to the gastric bare area adipose tissue: a poor prognostic predictor for gastric cancer. 61
33187517 2020
7
The efficacy of treating patients with non-metastatic gastric linitis plastica using surgery with chemotherapy and/or radiotherapy. 61
33313178 2020
8
Primary colorectal linitis plastica presenting as rapid acute deterioration: a diagnostic dilemma. 61
32374219 2020
9
Neoadjuvant chemotherapy plus surgery for high-risk advanced gastric cancer: long-term results of KDOG1001 trial. 61
32617667 2020
10
Impact of tumor regression grade on recurrence after preoperative chemoradiation and gastrectomy for gastric cancer. 61
32462681 2020
11
Development and internal validation of a diagnostic score for gastric linitis plastica. 61
32103376 2020
12
Metastasis From Gastric Signet Ring Cell Adenocarcinoma Presenting as a Rectosigmoid Stricture: A Rare Case. 61
32670689 2020
13
Metastatic Breast Cancer Presenting as a Gastric Primary with Linitis Plastica: a Case Report and Review of Literature. 61
32034640 2020
14
The role of EUS in missed and known linitis plastica. 61
32584317 2020
15
Cardia Gastric Cancer in the Gastric Pouch 5 Years after Gastric Bypass: A Case Report. 61
32078104 2020
16
Linitis Plastica: a Distinct Type of Gastric Cancer. 61
31754987 2020
17
Laparoscopic and endoscopic cooperative surgery for gastric cancer mimicking a submucosal tumor. 61
32394000 2020
18
Current status of perioperative chemotherapy for locally advanced gastric cancer and JCOG perspectives. 61
32134452 2020
19
Evaluation of the Association of Perioperative UGT1A1 Genotype-Dosed gFOLFIRINOX With Margin-Negative Resection Rates and Pathologic Response Grades Among Patients With Locally Advanced Gastroesophageal Adenocarcinoma: A Phase 2 Clinical Trial. 61
32058557 2020
20
Gastric metastasis resembling linitis plastica 17 years after lobular breast cancer. 61
31734112 2020
21
A Case Report of Linitis Plastica. 61
31979851 2020
22
Gastrointestinal: Secondary gastric linitis plastica: A peritoneal recurrence of breast cancer. 61
31264252 2019
23
Plasmacytoid Urothelial Carcinoma: An Unusual Variant That Warrants Aggressive Management and Critical Distinction on Transurethral Resections. 61
30865491 2019
24
An integrated analysis of two phase II trials (JCOG0001 and JCOG0405) of preoperative chemotherapy followed by D3 gastrectomy for gastric cancer with extensive lymph node metastasis. 61
31264058 2019
25
Poorly Cohesive Cell Carcinoma of the Gallbladder with Signet Rings and Neuroendocrine-Like Morphology: A Rare Incidental Histopathological Diagnosis with Lessons to Learn. 61
31644525 2019
26
Randomized phase III trial of gastrectomy with or without neoadjuvant S-1 plus cisplatin for type 4 or large type 3 gastric cancer, the short-term safety and surgical results: Japan Clinical Oncology Group Study (JCOG0501). 61
30827001 2019
27
Subcutaneous pantoprazole in an elderly, palliative care patient. 61
31462422 2019
28
Mucin-Containing Rectal Carcinomas: Overview of Unique Clinical and Imaging Features. 61
30995095 2019
29
Acute gastritis caused by concurrent infection with Epstein-Barr virus and cytomegalovirus in an immunocompetent adult. 61
30446952 2019
30
A phase II study of neoadjuvant chemotherapy with docetaxel, cisplatin, and S-1, followed by gastrectomy with D2 lymph node dissection for high-risk advanced gastric cancer: results of the KDOG1001 trial. 61
30284080 2019
31
Primary Gastric Small Cell Carcinoma (Presenting as Linitis Plastica) Diagnosed Using Endoscopic Ultrasound-Guided Biopsy: A Case Report. 61
30300982 2019
32
Linitis plastica of the colon due to metastases of invasive lobular breast carcinoma. 61
30859840 2019
33
A rare case of linitis plastica of the colon from ovarian carcinoma. 61
30949339 2019
34
Linitis plastica: 'leather bottle' stomach. 61
30295839 2019
35
Blocked by a Ring: A Case of Gastric Linitis Plastica Presenting as Large Bowel Obstruction Secondary to Rectal Stenosis. 61
31616715 2019
36
Late mesh migration after Nissen funduplication mimicking a gastric neoplasm. 61
30632376 2019
37
Endoscopic ultrasound-guided fine-needle aspiration used in diagnosing gastric linitis plastica: Metastatic lymph nodes can be valuable targets. 61
29864202 2019
38
Neoadjuvant therapy for locally advanced gastric cancer patients. A population pharmacodynamic modeling. 61
31071108 2019
39
Metastasectomy Improves the Survival of Gastric Cancer Patients with Krukenberg Tumors: A Retrospective Analysis of 182 patients. 61
31908529 2019
40
Clinicopathological Characteristics and Prognosis of Proximal and Distal Gastric Cancer during 1997-2017 in China National Cancer Center. 61
31312217 2019
41
Personalized therapy based on sequential molecular analysis leads to 30 months of survival in a patient with diffuse unresectable gastric linitis plastica. 61
29714649 2018
42
Exploring the differences between early-onset gastric cancer and traditional-onset gastric cancer. 61
30603136 2018
43
Gastric Metastasis Mimicking Linitis Plastica 20 Years after Primary Breast Cancer. A Case Report. 61
30574631 2018
44
Acute inflammation of the stomach mimicking linitis plastica. 61
30701166 2018
45
A randomized phase II multicenter trial to explore efficacy of weekly intraperitoneal in comparison with intravenous paclitaxel administered immediately after gastrectomy to the patients with high risk of peritoneal recurrence: final results of the INPACT trial. 61
29536296 2018
46
Endoscopic ultrasound-guided fine-needle aspiration biopsy for diagnosis of gastric linitis plastica with negative malignant endoscopy biopsies. 61
30250557 2018
47
Computed tomography and magnetic resonance imaging findings of metastatic rectal linitis plastica from prostate cancer: A case report and review of literature. 61
30397613 2018
48
Linitis plastica in excluded stomach after Roux-en-Y gastric bypass. 61
29634913 2018
49
The "leather bottle" stomach. 61
29260279 2018
50
Efficacy of a docetaxel-5FU-oxaliplatin regimen (TEFOX) in first-line treatment of advanced gastric signet ring cell carcinoma: an AGEO multicentre study. 61
29872148 2018

Variations for Linitis Plastica

Expression for Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for Linitis Plastica

Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.59 CDH1 CDX2 ERBB2 PGR

GO Terms for Linitis Plastica

Sources for Linitis Plastica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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