MCID: LNT001
MIFTS: 34

Linitis Plastica

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Linitis Plastica

MalaCards integrated aliases for Linitis Plastica:

Name: Linitis Plastica 11 43 14 71 75
Leather-Bottle Stomach 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4023
MeSH 43 D008039
NCIt 49 C3190
SNOMED-CT 68 307594007
UMLS 71 C0023743

Summaries for Linitis Plastica

MalaCards based summary: Linitis Plastica, also known as leather-bottle stomach, is related to diffuse gastric cancer and rectal benign neoplasm. An important gene associated with Linitis Plastica is PRSS1 (Serine Protease 1), and among its related pathways/superpathways are Adhesion and Pre-implantation embryo. Affiliated tissues include colon, breast and lymph node, and related phenotypes are neoplasm and endocrine/exocrine gland

Wikipedia: 75 Linitis plastica is a widely used term for Brinton's disease (also known as leather bottle stomach), a... more...

Related Diseases for Linitis Plastica

Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 449)
# Related Disease Score Top Affiliating Genes
1 diffuse gastric cancer 30.9 PRSS1 ERBB2 CTNNA1 CDH1
2 rectal benign neoplasm 30.7 KRT7 KRT20 CEACAM5 CDX2
3 gastric adenocarcinoma 30.6 KRT20 ERBB2 CEACAM5 CDX2 CDH1
4 gastric signet ring cell adenocarcinoma 30.4 PIP KRT7 CDX2 CDH1
5 adenocarcinoma 30.3 KRT7 KRT20 ERBB2 CEACAM5 CDX2 CDH1
6 signet ring cell adenocarcinoma 30.3 PIP KRT7 KRT20 ERBB2 CEACAM5 CDX2
7 hepatoid adenocarcinoma 30.2 KRT7 CEACAM5 CDX2
8 small cell carcinoma 30.2 KRT7 KRT20 CEACAM5
9 intestinal obstruction 30.2 KRT7 KRT20 CEACAM5 CDX2
10 neuroendocrine tumor 30.2 KRT20 CDX2 CDH1
11 gallbladder signet ring cell adenocarcinoma 30.1 KRT7 KRT20 CDX2 CDH1
12 transitional cell carcinoma 30.0 KRT7 KRT20 ERBB2 CDH1
13 diffuse gastric and lobular breast cancer syndrome 30.0 PRSS1 ERBB2 CTNNA1 CDH1
14 gallbladder adenocarcinoma 30.0 KRT7 ERBB2 CEACAM5 CDX2
15 microinvasive gastric cancer 30.0 ERBB2 CTNNA1 CEACAM5 CDX2 CDH1
16 colonic benign neoplasm 29.9 KRT7 KRT20 ERBB2 CEACAM5 CDX2 CDH1
17 rectum adenocarcinoma 29.7 KRT7 KRT20 ERBB2 CEACAM5 CDX2
18 breast ductal carcinoma 29.7 PIP PGR KRT7 ERBB2 CDH1
19 bladder adenocarcinoma 29.6 KRT7 KRT20 GATA3 CEACAM5 CDX2
20 paget disease, extramammary 29.5 PIP KRT7 KRT20 ERBB2 CEACAM5 CDX2
21 gallbladder cancer 29.5 KRT7 KRT20 ERBB2 CEACAM5 CDX2 CDH1
22 mammary paget's disease 29.2 PIP PGR KRT7 KRT20 ERBB2 CEACAM5
23 cholangiocarcinoma 29.2 KRT7 KRT20 ERBB2 CTNNA1 CEACAM5 CDX2
24 breast lobular carcinoma 29.1 PIP PGR KRT7 GATA3 ERBB2 CDH1
25 pancreatic cancer 28.9 PRSS1 KRT7 KRT20 ERBB2 CTNNA1 CEACAM5
26 breast adenocarcinoma 28.8 PIP PGR KRT7 GATA3 ERBB2 CEACAM5
27 breast cancer 28.6 PIP PGR KRT7 KRT20 GATA3 ERBB2
28 endometrial cancer 28.5 PGR KRT7 KRT20 ERBB2 CTNNA1 CEACAM5
29 gastric diffuse adenocarcinoma 27.1 SCN10A RPAP1 PIP PGR KRT7 KRT20
30 gastric linitis plastica 11.7
31 gastric cancer 10.8
32 bladder cancer 10.5
33 rectum cancer 10.5
34 coloboma of optic nerve 10.5
35 rare tumor 10.5
36 prostate cancer 10.4
37 gastritis 10.4
38 bladder signet ring cell adenocarcinoma 10.3 KRT7 CDX2
39 lymphoma, hodgkin, classic 10.3
40 inflammatory bowel disease 1 10.3
41 suppression of tumorigenicity 12 10.3
42 colitis 10.3
43 syphilis 10.3
44 ulcerative colitis 10.3
45 crohn's disease 10.3
46 ceruminoma 10.3 PIP KRT7
47 bile duct adenoma 10.3 KRT7 KRT20
48 bile duct signet ring cell carcinoma 10.3 KRT7 KRT20
49 ceruminous adenocarcinoma 10.3 PIP KRT7
50 endometrial transitional cell carcinoma 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to Linitis Plastica

Symptoms & Phenotypes for Linitis Plastica

MGI Mouse Phenotypes related to Linitis Plastica:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.63 CDH1 CDX2 CEACAM5 CTNNA1 ERBB2 PGR
2 endocrine/exocrine gland MP:0005379 9.56 CDH1 CDX2 CEACAM5 CTNNA1 ERBB2 GATA3
3 cardiovascular system MP:0005385 9.36 CDH1 CDX2 CEACAM5 CTNNA1 ERBB2 GATA3

Drugs & Therapeutics for Linitis Plastica

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Single-arm, Multi-center, Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Adult Patients With Advanced Scirrhous Gastric Carcinoma That Have Progressed After One or Two Prior Systemic Treatments Completed NCT01576380 Phase 2 TKI258

Search NIH Clinical Center for Linitis Plastica

Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

Organs/tissues related to Linitis Plastica:

MalaCards : Colon, Breast, Lymph Node, Prostate, Appendix, Small Intestine, Skin

Publications for Linitis Plastica

Articles related to Linitis Plastica:

(show top 50) (show all 549)
# Title Authors PMID Year
1
Linitis plastica of the rectum secondary to prostate carcinoma. 62
36460309 2022
2
Rectal linitis plastica as the first presentation of metastatic lobular breast cancer: an endoscopic ultrasound diagnosis. 62
36100806 2022
3
Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica. 62
36450891 2022
4
68 Ga-PSMA-11 PET/CT and PET/MRI in Rectal Linitis Plastica Secondary to Prostate Adenocarcinoma. 62
36327457 2022
5
Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report. 62
36387831 2022
6
Correction to: Metastatic Rectal Linitis Plastica From Bladder Cancer. 62
35926501 2022
7
Metastatic invasive lobular breast cancer presenting as linitis plastica of the colon: Tumour characterization using [18 F]FES PET/MRI. 62
34545689 2022
8
Subcutaneous pantoprazole in an elderly, palliative care patient. 62
31462422 2022
9
Comparison between signet-ring cell carcinoma and non-signet-ring cell carcinoma of the stomach: clinicopathological parameters, epidemiological data, outcome, and prognosis-a cohort study of 123 patients from a non-endemic country. 62
35858903 2022
10
pCLE detects mucosal neoplastic vascular pattern in gastric linitis plastica. 62
35650372 2022
11
Endoscopic ultrasound guided fine needle biopsy in patients with suspected gastric linitis plastica. 62
35301155 2022
12
Development of the PERI-Gastric (PEritoneal Recurrence Index) and PERI-Gram (Peritoneal Recurrence Index NomoGRAM) for predicting the risk of metachronous peritoneal carcinomatosis after gastrectomy with curative intent for gastric cancer. 62
34811622 2022
13
Use of endoscopic ultrasound-guided fine needle aspiration of the pancreas to diagnose a case of primary linitis plastica of the colon with retroperitoneal dissemination. 62
35310688 2022
14
Endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of gastric linitis plastica. 62
35310721 2022
15
Endoscopic ultrasound-guided fine-needle biopsy for the diagnosis of gastric metastasis from breast cancer mimicking primary linitis plastica: A case report. 62
35873519 2022
16
Positron emission tomography combined with computed tomography in the diagnosis of linitis plastica. Is it necessary or expendable? 62
35489587 2022
17
Gastric metastasis from breast cancer presenting as dysphagia. 62
35308257 2022
18
Usefulness of endoscopic ultrasound for acquiring the pathological diagnosis of gastrointestinal lymphoma. 62
35153173 2022
19
Primary acinic cell carcinoma of the breast is associated with a poor outcome: A case report and literature review. 62
35003741 2022
20
Gastric Linitis Plastica and role of endoscopic ultrasound: An under-recognised diagnostic modality. 62
35099463 2022
21
Linitis plastica: current prognostic implication of a classic concept. 62
35120115 2022
22
Infiltrative pattern of metastatic invasive lobular breast carcinoma in the abdomen: a pictorial review. 62
34894297 2021
23
The Burden of Peritoneal Metastases from Gastric Cancer: A Systematic Review on the Incidence, Risk Factors and Survival. 62
34768402 2021
24
Linitis plastica of the rectum secondary to metastatic prostate cancer: A case report of a rare presentation and literature review. 62
34759661 2021
25
Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research. 62
34620108 2021
26
Gastric linitis plastica due to signet-ring cell carcinoma with Krukenberg tumors diagnosed by endoscopic ultrasound-guided fine-needle aspiration. 62
33740238 2021
27
Diagnostic Value of EUS-Guided Fine-Needle Aspiration Biopsy for Gastric Linitis Plastica with Negative Endoscopic Biopsy. 62
34442011 2021
28
Gastrointestinal: Franseen-tip transmural fine-needle biopsy for localized gastric linitis plastica. 62
33305373 2021
29
[Progress in gastric cancer with positive peritoneal cytology]. 62
34000778 2021
30
Prognosis prediction model for a special entity of gastric cancer, linitis plastica. 62
34012628 2021
31
A CASE OF INFILTRATING LOBULAR CARCINOMA OF THE BREAST WITH GASTRIC METASTASIS 22 YEARS AFTER INITIAL SURGERY. 62
34588734 2021
32
Gastric metastases from invasive lobular carcinoma of the breast: Case report. 62
33318776 2021
33
A Rare Metastatic Site of Invasive Lobular Breast Carcinoma: A Case Report. 62
34853710 2021
34
Development of a Quantitative Diagnostic Criterion for Gastric Linitis Plastica: Findings From a Large Single-Institutional Study. 62
34422637 2021
35
Endoscopic ultrasound efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study. 62
33553343 2021
36
A Unique Case of Alpha-Fetoprotein-Negative Hepatoid Adenocarcinoma of the Stomach With Associated Signet Ring Cell Histological Features and Linitis Plastica. 62
33415058 2020
37
Cancer cells invasion to the gastric bare area adipose tissue: a poor prognostic predictor for gastric cancer. 62
33187517 2020
38
The efficacy of treating patients with non-metastatic gastric linitis plastica using surgery with chemotherapy and/or radiotherapy. 62
33313178 2020
39
Primary colorectal linitis plastica presenting as rapid acute deterioration: a diagnostic dilemma. 62
32374219 2020
40
Impact of tumor regression grade on recurrence after preoperative chemoradiation and gastrectomy for gastric cancer. 62
32462681 2020
41
Neoadjuvant chemotherapy plus surgery for high-risk advanced gastric cancer: long-term results of KDOG1001 trial. 62
32617667 2020
42
Development and internal validation of a diagnostic score for gastric linitis plastica. 62
32103376 2020
43
Metastasis From Gastric Signet Ring Cell Adenocarcinoma Presenting as a Rectosigmoid Stricture: A Rare Case. 62
32670689 2020
44
Metastatic Breast Cancer Presenting as a Gastric Primary with Linitis Plastica: a Case Report and Review of Literature. 62
32034640 2020
45
The role of EUS in missed and known linitis plastica. 62
32584317 2020
46
Cardia Gastric Cancer in the Gastric Pouch 5 Years after Gastric Bypass: A Case Report. 62
32078104 2020
47
Current status of perioperative chemotherapy for locally advanced gastric cancer and JCOG perspectives. 62
32134452 2020
48
Laparoscopic and endoscopic cooperative surgery for gastric cancer mimicking a submucosal tumor. 62
32394000 2020
49
Linitis Plastica: a Distinct Type of Gastric Cancer. 62
31754987 2020
50
Evaluation of the Association of Perioperative UGT1A1 Genotype-Dosed gFOLFIRINOX With Margin-Negative Resection Rates and Pathologic Response Grades Among Patients With Locally Advanced Gastroesophageal Adenocarcinoma: A Phase 2 Clinical Trial. 62
32058557 2020

Variations for Linitis Plastica

Expression for Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for Linitis Plastica

Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 CTNNA1 CEACAM5 CDH1
2 10.56 GATA3 CDX2 CDH1
3 10.51 CTNNA1 CDH1
4 10.07 PGR ERBB2

GO Terms for Linitis Plastica

Cellular components related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 flotillin complex GO:0016600 8.92 CTNNA1 CDH1

Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell motility GO:2000146 9.26 GATA3 CTNNA1
2 cellular response to indole-3-methanol GO:0071681 8.92 CTNNA1 CDH1

Sources for Linitis Plastica

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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