MCID: LNT001
MIFTS: 35

Linitis Plastica

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Linitis Plastica

MalaCards integrated aliases for Linitis Plastica:

Name: Linitis Plastica 12 44 15 73
Leather-Bottle Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4023
MeSH 44 D008039
NCIt 50 C3190
SNOMED-CT 68 307594007 37995004
UMLS 73 C0023743

Summaries for Linitis Plastica

MalaCards based summary : Linitis Plastica, also known as leather-bottle stomach, is related to gastric diffuse adenocarcinoma and signet ring cell adenocarcinoma. An important gene associated with Linitis Plastica is PRSS1 (Serine Protease 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cytoskeletal Signaling. The drugs Cisplatin and s 1 (combination) have been mentioned in the context of this disorder. Affiliated tissues include colon, lymph node and appendix.

Wikipedia : 76 Linitis plastica, also known as Brinton\'s disease or leather bottle stomach, is a morphological variant... more...

Related Diseases for Linitis Plastica

Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 gastric diffuse adenocarcinoma 29.8 CDH1 KRT20 KRT7 MMP15
2 signet ring cell adenocarcinoma 29.6 CDH1 KRT20 KRT7
3 gastric adenocarcinoma 29.5 CDH1 KRT20 KRT7
4 transitional cell carcinoma 29.3 CDH1 KRT20 KRT7
5 gastric linitis plastica 12.4
6 tropical calcific pancreatitis 10.5 PRSS1 PRSS2
7 adenocarcinoma 10.4
8 gastric cancer 10.4
9 renal pelvis adenocarcinoma 10.3 CDH1 KRT7
10 breast cancer 10.3
11 colitis 10.3
12 breast adenomyoepithelioma 10.3 CDH1 KRT7
13 breast myoepithelial neoplasm 10.3 CDH1 KRT7
14 ulcerative colitis 10.2
15 gastritis 10.2
16 cystic basal cell carcinoma 10.2 KRT20 KRT7
17 vaginal benign neoplasm 10.2 KRT20 KRT7
18 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
19 transverse colon cancer 10.2 KRT20 KRT7
20 appendix adenocarcinoma 10.2 KRT20 KRT7
21 ovarian large-cell neuroendocrine carcinoma 10.2 KRT20 KRT7
22 vaginal adenoma 10.2 KRT20 KRT7
23 vaginal tubulovillous adenoma 10.2 KRT20 KRT7
24 eyelid neoplasm 10.2 KRT20 KRT7
25 glandular cystitis 10.2 KRT20 KRT7
26 corneal dystrophy, posterior polymorphous, 3 10.2 CDH1 KRT7
27 malignant syringoma 10.2 KRT20 KRT7
28 krukenberg carcinoma 10.2 KRT20 KRT7
29 lung acinar adenocarcinoma 10.2 KRT20 KRT7
30 small cell carcinoma of the bladder 10.2 KRT20 KRT7
31 goblet cell carcinoid 10.2 CDH1 KRT20
32 eccrine sweat gland neoplasm 10.2 KRT20 KRT7
33 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT20 KRT7
34 vulval paget's disease 10.2 KRT20 KRT7
35 morpheaform basal cell carcinoma 10.2 CDH1 KRT20
36 bile duct cystadenocarcinoma 10.2 KRT20 KRT7
37 intratubular embryonal carcinoma 10.2 KRT20 KRT7
38 ovarian mucinous adenocarcinoma 10.2 KRT20 KRT7
39 thymus adenocarcinoma 10.2 KRT20 KRT7
40 meibomian cyst 10.2 KRT20 KRT7
41 bladder lymphoma 10.2 KRT20 KRT7
42 papillary serous adenocarcinoma 10.2 KRT20 KRT7
43 bladder adenocarcinoma 10.2 KRT20 KRT7
44 papillary adenocarcinoma 10.2 CDH1 KRT7
45 jejunal adenocarcinoma 10.2 KRT20 KRT7
46 chronic cystitis 10.2 KRT20 KRT7
47 vulva adenocarcinoma 10.2 KRT20 KRT7
48 medulloepithelioma 10.2 KRT20 KRT7
49 glycogen-rich clear cell breast carcinoma 10.2 KRT20 KRT7
50 pancreatitis, hereditary 10.2 PRSS1 PRSS2

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to Linitis Plastica

Symptoms & Phenotypes for Linitis Plastica

Drugs & Therapeutics for Linitis Plastica

Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
s 1 (combination) Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric Cancer Completed NCT00252161 Phase 3 Neoadjuvant chemotherapy(TS-1+CDDP) followed by gastrectomy
2 A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma Patients Completed NCT01576380 Phase 2 TKI258

Search NIH Clinical Center for Linitis Plastica

Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

MalaCards organs/tissues related to Linitis Plastica:

41
Colon, Lymph Node, Appendix, Prostate, Skin, Bone

Publications for Linitis Plastica

Articles related to Linitis Plastica:

(show top 50) (show all 199)
# Title Authors Year
1
Personalized therapy based on sequential molecular analysis leads to 30 months of survival in a patient with diffuse unresectable gastric linitis plastica. ( 29714649 )
2018
2
Endoscopic Ultrasound Guided Fine Needle Aspiration used in diagnosing Gastric Linitis Plastica: Metastatic Lymph Nodes can be valuable targets. ( 29864202 )
2018
3
Linitis plastica in excluded stomach after Roux-en-Y gastric bypass. ( 29634913 )
2018
4
IgM- Kappa type multiple myeloma with simultaneous gastro-esophageal involvement simulating linitis plastica. ( 29747781 )
2018
5
The significance of a nineteenth century definition in the era of genomics: linitis plastica. ( 28679451 )
2017
6
Incomplete resection and linitis plastica are factors for poor survival after extended multiorgan resection in gastric cancer patients. ( 29150634 )
2017
7
Clinical Outcomes after Surgery for Linitis Plastica of the Stomach: Analysis of a Population Cancer Registry. ( 28234115 )
2017
8
Linitis plastica: a harbinger of an unusual cause of gastric wall thickening. ( 29905314 )
2017
9
Urothelial Carcinoma of the Ureter and Urinary Bladder With Rectal Linitis Plastica. ( 28153589 )
2017
10
A case report of gastric linitis plastica diagnosed by endoscopic ultrasound-guided fine needle aspiration. ( 29390283 )
2017
11
Dermatomyositis revealing both a metastatic linitis plastica and hepatitis C virus infection. ( 28731019 )
2017
12
Image Diagnosis: A Gastric Signet-Ring Adenocarcinoma of Type Linitis Plastica Mimicking Splenomegaly in a Patient with Chronic Lymphocytic Leukemia. ( 28609263 )
2017
13
Linitis Plastica of Muscle Fascia Presenting as Tiptoeing Gait. ( 28809600 )
2017
14
An Unusual Cause of Gastric Linitis Plastica. ( 27810370 )
2016
15
Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging. ( 26814502 )
2016
16
Survival following operative management of gastric linitis plastica compared with non-operative management. ( 27809576 )
2016
17
Advanced gastric cancer linitis plastica presented with disseminated intravascular coagulation. ( 27803086 )
2016
18
Metastatic pancreatic cancer presenting as linitis plastica of the stomach. ( 26957034 )
2016
19
Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient. ( 27721883 )
2016
20
Linitis plastica like primary signet ring cell carcinoma of the gallbladder - an extremely rare variant. ( 28195258 )
2016
21
Linitis Plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass. A Case Report. ( 27397038 )
2016
22
Jackhammer oesophagus in a case of linitis plastica. ( 27174454 )
2016
23
Gastric Crohns presenting as linitis plastica. ( 26710492 )
2015
24
Recurrent bladder cancer presenting as rectal linitis plastica. ( 25734804 )
2015
25
Primary Linitis Plastica of the Rectum: Focus on Magnetic Resonance Imaging Patterns and Treatment Options. ( 26322720 )
2015
26
Submucosal Endoscopic Sampling for Indefinite Gastric Linitis Plastica Infiltrating into the Submucosal Layer. ( 26405710 )
2015
27
Is Linitis Plastica a Contraindication for Surgical Resection: A Multi-Institution Study of the U.S. Gastric Cancer Collaborative. ( 26530447 )
2015
28
Characteristic waffle-like appearance of gastric linitis plastica: A case report. ( 25435971 )
2015
29
Endoscopic ultrasound of isolated gastric corrosive stricture mimicking linitis plastica. ( 25789288 )
2015
30
Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report. ( 26788154 )
2015
31
Primary linitis plastica of the entire colon in a background of ulcerative colitis: a case report. ( 25649787 )
2015
32
Primary linitis plastica of the rectum. ( 26895130 )
2015
33
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. ( 24982453 )
2014
34
Gastric lymphocytic phlebitis as a differential diagnosis of linitis plastica. ( 24896765 )
2014
35
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. ( 23984032 )
2013
36
Linitis plastica presenting two years after elective Roux-en-Y gastric bypass for treatment of morbid obesity: a case report and review of the literature. ( 24060402 )
2013
37
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. ( 24009205 )
2013
38
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the staging of linitis plastica caused by primary gastric adenocarcinoma. ( 25125999 )
2013
39
Gastric linitis plastica: which role for surgical resection? ( 21717092 )
2012
40
Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography Pattern in a Patient with Linitis Plastica of the Stomach Caused by Primary Signet Cell Adenocarcinoma. ( 22942780 )
2012
41
Case report and review of the literature: Rectal linitis plastica secondary to the lipoid cell variant of transitional cell carcinoma of the urinary bladder. ( 23282659 )
2012
42
Secondary rectal linitis plastica as first manifestation of urinary bladder carcinoma. ( 24714188 )
2012
43
Metastatic lobular breast cancer presenting as gastric linitis plastica. ( 21571246 )
2011
44
Primary linitis plastica of the sigmoid colon. ( 21277393 )
2011
45
Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment. ( 21345767 )
2011
46
Metastatic breast carcinoma simulating linitis plastica of the colon: report of a case. ( 21431489 )
2011
47
Breast carcinoma presenting as linitis plastica. ( 19695970 )
2010
48
Primary linitis plastica of the right colon. ( 19886554 )
2009
49
Facing the challenge of managing linitis plastica--review of the literature. ( 20214236 )
2009
50
Colorectal linitis plastica complicating chronic ulcerative colitis. ( 18798572 )
2009

Variations for Linitis Plastica

Expression for Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for Linitis Plastica

Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 CDH1 MMP15 PRSS1 PRSS2
2 11.82 CDH1 KRT20 KRT7
3 11.24 PRSS1 PRSS2
4
Show member pathways
10.79 MMP15 PRSS1 PRSS2

GO Terms for Linitis Plastica

Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen catabolic process GO:0030574 9.16 MMP15 PRSS2
2 digestion GO:0007586 8.96 PRSS1 PRSS2
3 extracellular matrix disassembly GO:0022617 8.92 CDH1 MMP15 PRSS1 PRSS2

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 8.8 MMP15 PRSS1 PRSS2

Sources for Linitis Plastica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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