MCID: LNT001
MIFTS: 36

Linitis Plastica

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Linitis Plastica

MalaCards integrated aliases for Linitis Plastica:

Name: Linitis Plastica 12 44 15 73
Leather-Bottle Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4023
MeSH 44 D008039
NCIt 50 C3190
SNOMED-CT 68 37995004
UMLS 73 C0023743

Summaries for Linitis Plastica

MalaCards based summary : Linitis Plastica, also known as leather-bottle stomach, is related to gastric diffuse adenocarcinoma and small cell carcinoma. An important gene associated with Linitis Plastica is PRSS1 (Serine Protease 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cytoskeletal Signaling. The drugs Cisplatin and s 1 (combination) have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and liver.

Wikipedia : 76 Linitis plastica, also known as Brinton''s disease or leather bottle stomach, is a morphological variant... more...

Related Diseases for Linitis Plastica

Diseases related to Linitis Plastica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 gastric diffuse adenocarcinoma 31.4 CDH1 KRT20 KRT7 MMP15
2 small cell carcinoma 30.3 KRT20 KRT7
3 gastric adenocarcinoma 30.2 CDH1 KRT20 KRT7
4 signet ring cell adenocarcinoma 30.2 CDH1 KRT20 KRT7
5 intrahepatic cholangiocarcinoma 30.0 CDH1 KRT20 KRT7
6 cholangiocarcinoma 30.0 CDH1 KRT20 KRT7
7 transitional cell carcinoma 30.0 CDH1 KRT20 KRT7
8 gastric linitis plastica 12.6
9 adenocarcinoma 10.6
10 gastric cancer 10.5
11 breast cancer 10.5
12 colitis 10.4
13 ulcerative colitis 10.4
14 gastritis 10.4
15 degos 'en cocarde' erythrokeratoderma 10.4
16 bladder cancer 10.3
17 lymphoma 10.3
18 sarcoma 10.3
19 syphilis 10.3
20 tropical calcific pancreatitis 10.1 PRSS1 PRSS2
21 leukemia, chronic lymphocytic 2 10.1
22 leukemia, chronic lymphocytic 10.1
23 prostate cancer 10.1
24 lymphoma, hodgkin, classic 10.1
25 myeloma, multiple 10.1
26 pancreatic cancer 10.1
27 lymphoma, non-hodgkin, familial 10.1
28 hepatitis c virus 10.1
29 crohn's disease 10.1
30 hepatitis 10.1
31 leukemia 10.1
32 morbid obesity 10.1
33 crohn's colitis 10.1
34 dermatomyositis 10.1
35 lymphocytic leukemia 10.1
36 gastric lymphoma 10.1
37 microinvasive gastric cancer 10.1
38 disseminated intravascular coagulation 10.1
39 hepatitis c 10.1
40 macrocytic anemia 10.1
41 breast ductal carcinoma 10.1
42 gallbladder signet ring cell adenocarcinoma 10.1
43 gastric small cell carcinoma 10.1
44 situs inversus 10.1
45 peritonitis 10.1
46 viral infectious disease 10.1
47 leukemia, b-cell, chronic 10.1
48 splenomegaly 10.1
49 renal pelvis adenocarcinoma 10.1 CDH1 KRT7
50 breast adenomyoepithelioma 10.1 CDH1 KRT7

Graphical network of the top 20 diseases related to Linitis Plastica:



Diseases related to Linitis Plastica

Symptoms & Phenotypes for Linitis Plastica

Drugs & Therapeutics for Linitis Plastica

Drugs for Linitis Plastica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
2
s 1 (combination) Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Neoadjuvant TS-1 and Cisplatin for Type 4 and Large Type 3 Gastric Cancer Completed NCT00252161 Phase 3 Neoadjuvant chemotherapy(TS-1+CDDP) followed by gastrectomy
2 A Phase II Study to Evaluate Efficacy and Safety of Dovitinib (TKI258) in Advanced Scirrhous Gastric Carcinoma Patients Completed NCT01576380 Phase 2 TKI258

Search NIH Clinical Center for Linitis Plastica

Cochrane evidence based reviews: linitis plastica

Genetic Tests for Linitis Plastica

Anatomical Context for Linitis Plastica

MalaCards organs/tissues related to Linitis Plastica:

41
Colon, Breast, Liver, Prostate, Appendix, Kidney, Thymus

Publications for Linitis Plastica

Articles related to Linitis Plastica:

(show top 50) (show all 212)
# Title Authors Year
1
Personalized therapy based on sequential molecular analysis leads to 30 months of survival in a patient with diffuse unresectable gastric linitis plastica. ( 29714649 )
2018
2
Endoscopic Ultrasound Guided Fine Needle Aspiration used in diagnosing Gastric Linitis Plastica: Metastatic Lymph Nodes can be valuable targets. ( 29864202 )
2018
3
Linitis plastica in excluded stomach after Roux-en-Y gastric bypass. ( 29634913 )
2018
4
IgM- Kappa type multiple myeloma with simultaneous gastro-esophageal involvement simulating linitis plastica. ( 29747781 )
2018
5
Cholangiocarcinoma Presenting as Linitis Plastica with Unusual Metastases to the Psoas Muscle and Urinary Bladder. ( 30038923 )
2018
6
Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review. ( 30073103 )
2018
7
Endoscopic ultrasound-guided fine-needle aspiration biopsy for diagnosis of gastric linitis plastica with negative malignant endoscopy biopsies. ( 30250557 )
2018
8
Computed tomography scan efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study. ( 30288113 )
2018
9
Primary Gastric Small Cell Carcinoma (Presenting as Linitis Plastica) Diagnosed Using Endoscopic Ultrasound-Guided Biopsy: A Case Report. ( 30300982 )
2018
10
Linitis plastica: "leather bottle" stomach. ( 30295839 )
2018
11
Computed tomography and magnetic resonance imaging findings of metastatic rectal linitis plastica from prostate cancer: A case report and review of literature. ( 30397613 )
2018
12
The "leather bottle" stomach. ( 29260279 )
2018
13
The significance of a nineteenth century definition in the era of genomics: linitis plastica. ( 28679451 )
2017
14
Incomplete resection and linitis plastica are factors for poor survival after extended multiorgan resection in gastric cancer patients. ( 29150634 )
2017
15
Clinical Outcomes after Surgery for Linitis Plastica of the Stomach: Analysis of a Population Cancer Registry. ( 28234115 )
2017
16
Linitis plastica: a harbinger of an unusual cause of gastric wall thickening. ( 29905314 )
2017
17
Urothelial Carcinoma of the Ureter and Urinary Bladder With Rectal Linitis Plastica. ( 28153589 )
2017
18
A case report of gastric linitis plastica diagnosed by endoscopic ultrasound-guided fine needle aspiration. ( 29390283 )
2017
19
Dermatomyositis revealing both a metastatic linitis plastica and hepatitis C virus infection. ( 28731019 )
2017
20
Image Diagnosis: A Gastric Signet-Ring Adenocarcinoma of Type Linitis Plastica Mimicking Splenomegaly in a Patient with Chronic Lymphocytic Leukemia. ( 28609263 )
2017
21
Linitis Plastica of Muscle Fascia Presenting as Tiptoeing Gait. ( 28809600 )
2017
22
An Unusual Cause of Gastric Linitis Plastica. ( 27810370 )
2016
23
Computed tomography features of gastrointestinal linitis plastica: spectrum of findings in early and delayed phase imaging. ( 26814502 )
2016
24
Survival following operative management of gastric linitis plastica compared with non-operative management. ( 27809576 )
2016
25
Advanced gastric cancer linitis plastica presented with disseminated intravascular coagulation. ( 27803086 )
2016
26
Metastatic pancreatic cancer presenting as linitis plastica of the stomach. ( 26957034 )
2016
27
Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient. ( 27721883 )
2016
28
Linitis plastica like primary signet ring cell carcinoma of the gallbladder - an extremely rare variant. ( 28195258 )
2016
29
Linitis Plastica of the bypassed stomach 7 years after Roux-en-Y gastric bypass. A Case Report. ( 27397038 )
2016
30
Jackhammer oesophagus in a case of linitis plastica. ( 27174454 )
2016
31
Gastric Crohns presenting as linitis plastica. ( 26710492 )
2015
32
Recurrent bladder cancer presenting as rectal linitis plastica. ( 25734804 )
2015
33
Primary Linitis Plastica of the Rectum: Focus on Magnetic Resonance Imaging Patterns and Treatment Options. ( 26322720 )
2015
34
Submucosal Endoscopic Sampling for Indefinite Gastric Linitis Plastica Infiltrating into the Submucosal Layer. ( 26405710 )
2015
35
Is Linitis Plastica a Contraindication for Surgical Resection: A Multi-Institution Study of the U.S. Gastric Cancer Collaborative. ( 26530447 )
2015
36
Characteristic waffle-like appearance of gastric linitis plastica: A case report. ( 25435971 )
2015
37
Endoscopic ultrasound of isolated gastric corrosive stricture mimicking linitis plastica. ( 25789288 )
2015
38
Metastatic gastric carcinoma from breast cancer mimicking primary linitis plastica: A case report. ( 26788154 )
2015
39
Primary linitis plastica of the entire colon in a background of ulcerative colitis: a case report. ( 25649787 )
2015
40
Primary linitis plastica of the rectum. ( 26895130 )
2015
41
Linitis Plastica of the Rectum As a Clinical Presentation of Metastatic Lobular Carcinoma of the Breast. ( 24982453 )
2014
42
Gastric lymphocytic phlebitis as a differential diagnosis of linitis plastica. ( 24896765 )
2014
43
Managing Gastric Linitis Plastica: Keep the scalpel sheathed. ( 23984032 )
2013
44
Linitis plastica presenting two years after elective Roux-en-Y gastric bypass for treatment of morbid obesity: a case report and review of the literature. ( 24060402 )
2013
45
Endoscopic ultrasonographic features of gastric linitis plastica in fifty-five Chinese patients. ( 24009205 )
2013
46
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the staging of linitis plastica caused by primary gastric adenocarcinoma. ( 25125999 )
2013
47
Diffuse Signet-Ring Cell Gastric Adenocarcinoma "Linitis Plastica" and Pernicious Anemia: a Rare Association. ( 22760711 )
2012
48
Gastric linitis plastica: which role for surgical resection? ( 21717092 )
2012
49
Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography Pattern in a Patient with Linitis Plastica of the Stomach Caused by Primary Signet Cell Adenocarcinoma. ( 22942780 )
2012
50
Case report and review of the literature: Rectal linitis plastica secondary to the lipoid cell variant of transitional cell carcinoma of the urinary bladder. ( 23282659 )
2012

Variations for Linitis Plastica

Expression for Linitis Plastica

Search GEO for disease gene expression data for Linitis Plastica.

Pathways for Linitis Plastica

Pathways related to Linitis Plastica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 CDH1 MMP15 PRSS1 PRSS2
2 11.82 CDH1 KRT20 KRT7
3 11.24 PRSS1 PRSS2
4
Show member pathways
10.79 MMP15 PRSS1 PRSS2

GO Terms for Linitis Plastica

Biological processes related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen catabolic process GO:0030574 9.16 MMP15 PRSS2
2 digestion GO:0007586 8.96 PRSS1 PRSS2
3 extracellular matrix disassembly GO:0022617 8.8 MMP15 PRSS1 PRSS2

Molecular functions related to Linitis Plastica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 8.8 MMP15 PRSS1 PRSS2

Sources for Linitis Plastica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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