Lip Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LPC002 MIFTS: 45	Lip Cancer Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Lip Cancer

MalaCards integrated aliases for Lip Cancer:

Name: Lip Cancer ¹² ¹⁵ ¹⁷

Malignant Neoplasm of Lip ¹² ³²

Lip Neoplasms ⁴⁴ ⁷⁰

Malignant Neoplasm of Oral Aspect of Lip, Not Specified Whether Upper or Lower ¹²

Malignant Neoplasm of External Lip, Not Specified As Upper or Lower ¹²

Malignant Neoplasm of Labial Commissure of Lip ¹²

Malignant Neoplasm of Lower Lip, Buccal Aspect ¹²

Malignant Neoplasm of Lower Lip, Inner Aspect ¹²

Malignant Neoplasm of Vermilion Border of Lip ¹²

Malignant Neoplasm of Lower Lip, Oral Aspect ¹²

Malignant Neoplasm of Lip, Vermilion Border ¹²

Malignant Neoplasm of Other Sites of Lip ¹²

Malignant Neoplasm of Commissure of Lip ¹²

Malignant Neoplasm of Lip, Inner Aspect ¹²

Malignant Neoplasm of Lower Lip, Mucosa ¹²

Malignant Tumor of Lower Labial Mucosa ¹²

Malignant Tumour of Labial Commissure ¹²

Malignant Tumor of Commissure of Lip ¹²

Malignant Neoplasm of Lip, External ¹²

Malignant Tumor of Labial Mucosa ¹²

Malignant Tumor of the Lip ¹²

Malignant Tumour of Lip ¹²

Malignant Tumor of Lip ¹²

Cancer of Lip ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Oral diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms of lip, oral cavity and pharynx

Malignant neoplasm of lip

Malignant neoplasm: Commissure of lip

Malignant neoplasm: External lip, unspecified

Malignant neoplasm: Lip, unspecified

Malignant neoplasm: Lip, unspecified, inner aspect

Malignant neoplasm: Lower lip, inner aspect

External Ids:

Disease Ontology ¹² DOID:8564

ICD9CM ³⁴ 140 140.6 140.8

MeSH ⁴⁴ D008048

NCIt ⁵⁰ C7485

SNOMED-CT ⁶⁷ 187626009 93762003 93869001

ICD10 ³² C00 C00.2 C00.4 more

EFO ¹⁷ EFO_1001019

UMLS ⁷⁰ C0023761 C0153340 C0153346 more

Sources

Summaries for Lip Cancer

MalaCards based summary : Lip Cancer, also known as malignant neoplasm of lip, is related to oral cancer and actinic cheilitis. An important gene associated with Lip Cancer is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Endometrial cancer and Measles. The drugs Heparin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Sources

Related Diseases for Lip Cancer

Diseases in the Lip Cancer family:

Lip Carcinoma in Situ

Diseases related to Lip Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)

#	Related Disease	Score	Top Affiliating Genes
1	oral cancer	31.6	TP53 MDM2 CDKN1A
2	actinic cheilitis	30.3	TP53 MSH2 MDM2 CDKN1A
3	cheilitis	30.3	TP53 MSH2 MDM2 CDKN1A
4	angiosarcoma	29.9	TP53 PDPN MDM2
5	basal cell carcinoma	29.7	TP53 MSH2 MDM2 CDKN1A CD44
6	skin carcinoma	29.6	TP53 MSH2 MDM2 CDKN1A CD44 BRAF
7	skin melanoma	29.4	TP53 MDM2 CDKN1A BRAF
8	adenocarcinoma	29.2	TP53 MSH2 MDM2 CDKN1A BRAF
9	squamous cell carcinoma	29.1	TP53 PDPN CDKN1A CD44 BRAF
10	lower lip cancer	11.3
11	upper lip cancer	11.2
12	ring chromosome 7	10.3	TP53 MDM2
13	ring chromosome	10.3	TP53 MDM2
14	esophagus verrucous carcinoma	10.3	TP53 MDM2
15	penile benign neoplasm	10.3	TP53 PDPN
16	undifferentiated embryonal sarcoma of the liver	10.3	TP53 MDM2
17	embryonal sarcoma	10.3	TP53 MDM2
18	pediatric liposarcoma	10.3	TP53 MDM2
19	xanthogranulomatous cholecystitis	10.3	TP53 PDPN
20	periosteal osteogenic sarcoma	10.3	TP53 MDM2
21	conjunctival squamous cell carcinoma	10.3	TP53 PDPN
22	maxillary sinus adenocarcinoma	10.3	TP53 MDM2
23	supraglottis cancer	10.3	TP53 PDPN
24	peripheral osteosarcoma	10.3	TP53 MDM2
25	soft tissue sarcoma	10.3	TP53 MDM2
26	parameningeal embryonal rhabdomyosarcoma	10.3	TP53 MDM2
27	nevus of ota	10.3	TP53 BRAF
28	conventional fibrosarcoma	10.3	TP53 MDM2
29	adult astrocytic tumour	10.3	TP53 MDM2
30	cervical adenoma malignum	10.3	TP53 MSH2
31	cervical adenosarcoma	10.3	TP53 MSH2
32	keratocystic odontogenic tumor	10.3	TP53 PDPN
33	spitz nevus	10.3	TP53 BRAF
34	malignant spiradenoma	10.3	TP53 MDM2
35	laryngeal benign neoplasm	10.3	TP53 PDPN
36	familial retinoblastoma	10.2	TP53 MDM2
37	anal squamous cell carcinoma	10.2	TP53 MDM2
38	sapho syndrome	10.2	TP53 MDM2
39	human papillomavirus infectious disease	10.2	TP53 CDKN1A
40	colorectal cancer, hereditary nonpolyposis, type 5	10.2	MSH2 BRAF
41	sarcomatoid renal cell carcinoma	10.2	TP53 MDM2
42	female reproductive endometrioid cancer	10.2	TP53 MSH2
43	suppressor of tumorigenicity 3	10.2	TP53 CDKN1A
44	bladder transitional cell papilloma	10.2	TP53 CDKN1A
45	adenofibroma	10.2	TP53 BRAF
46	melanotic neuroectodermal tumor	10.2	MDM2 BRAF
47	duodenum cancer	10.2	TP53 MSH2
48	invasive bladder transitional cell carcinoma	10.2	TP53 CDKN1A
49	duodenum disease	10.2	TP53 MSH2
50	nodular malignant melanoma	10.2	TP53 BRAF

Graphical network of the top 20 diseases related to Lip Cancer:

Sources

Symptoms & Phenotypes for Lip Cancer

GenomeRNAi Phenotypes related to Lip Cancer according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.28	CDKN1A
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.28	BRAF CDKN1A TP53
3	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.28	CDKN1A MDM2 MSH2 SUMO1 TP53

MGI Mouse Phenotypes related to Lip Cancer:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.86	BRAF CD44 CDKN1A MDM2 MSH2 PDPN
2	integument	MP:0010771	9.7	BRAF CD44 CDKN1A MDM2 MSH2 PDPN
3	muscle	MP:0005369	9.43	BRAF CD44 CDKN1A MDM2 PDPN TP53
4	neoplasm	MP:0002006	9.1	BRAF CD44 CDKN1A MDM2 MSH2 TP53

Sources

Drugs & Therapeutics for Lip Cancer

Drugs for Lip Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Heparin

Approved, Investigational

Phase 3

9005-49-6

772 9812414

Cisplatin

Approved

Phase 2, Phase 3

15663-27-1

84093 441203 2767

Durvalumab

Approved, Investigational

Phase 2, Phase 3

1428935-60-7

Cetuximab

Approved

Phase 2, Phase 3

205923-56-4

56842117 2333

Hemostatics

Phase 3

Coagulants

Phase 3

Tolonium Chloride

Phase 3

calcium heparin

Phase 3

Erlotinib Hydrochloride

Phase 3

183319-69-9

176871

Immunologic Factors

Phase 2, Phase 3

Antibodies

Phase 2, Phase 3

Immunoglobulins

Phase 2, Phase 3

Immunoglobulin G

Phase 2, Phase 3

Immunoglobulins, Intravenous

Phase 2, Phase 3

Antibodies, Monoclonal

Phase 2, Phase 3

Aminolevulinic acid

Approved

Phase 1, Phase 2

106-60-5

137

Orange

Approved

Phase 1, Phase 2

Paclitaxel

Approved, Vet_approved

Phase 2

33069-62-4

36314

Carboplatin

Approved

Phase 2

41575-94-4

10339178 498142 38904

Photosensitizing Agents

Phase 1, Phase 2

Dermatologic Agents

Phase 1, Phase 2

Mitogens

Phase 1, Phase 2

Tubulin Modulators

Phase 2

Antimitotic Agents

Phase 2

Albumin-Bound Paclitaxel

Phase 2

Anti-Infective Agents

Phase 2

Antidotes

Phase 2

Chelating Agents

Phase 2

Antioxidants

Phase 2

Protective Agents

Phase 2

sodium thiosulfate

Phase 2

Antitubercular Agents

Phase 2

Anti-Bacterial Agents

Phase 2

Vaccines

Phase 2

Gemcitabine

Approved

Phase 1

95058-81-4

60750

Doxycycline

Approved, Investigational, Vet_approved

Phase 1

564-25-0

54671203

Pembrolizumab

Approved

Phase 1

1374853-91-4

Pharmaceutical Solutions

Phase 1

Antiviral Agents

Phase 1

Antiparasitic Agents

Phase 1

Antimalarials

Phase 1

Antiprotozoal Agents

Phase 1

Antineoplastic Agents, Immunological

Phase 1

Nicotine

Approved

54-11-5

942 89594

Ethanol

Approved

64-17-5

702

Endothelial Growth Factors

Anesthetics

Tea

Interventional clinical trials:

(show all 48)

#	Name	Status	NCT ID	Phase	Drugs
1	The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor	Recruiting	NCT03017053	Phase 4
2	Canadian Optically Guided Approach for Oral Lesions Surgical Trial - COOLS	Unknown status	NCT01039298	Phase 3
3	Comparing the Test Characteristics of Three Oral Cancer Screening Techniques:1)Unaided Visual Examination 2)VelScope Examination and 3)Toluidine Blue Application, by Trained Primary Health Care Workers in Mumbai, India.	Unknown status	NCT00655421	Phase 3
4	Erlotinib Prevention of Oral Cancer (EPOC)	Completed	NCT00402779	Phase 3	Erlotinib;Placebo
5	Workplace Tobacco Cessation And Oral Cancer Screening Study	Completed	NCT00750503	Phase 3
6	Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survivor Trial	Recruiting	NCT04713449	Phase 3
7	Randomized Phase II/III Trial of Radiotherapy With Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy With Concurrent Cetuximab in Patients With Locoregionally Advanced Head and Neck Cancer With a Contraindication to Cisplatin	Recruiting	NCT03258554	Phase 2, Phase 3
8	Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer	Recruiting	NCT04333537	Phase 2, Phase 3	Imaging Agent
9	Clinical Protocol for Wild Type p53 Gene Induction in Premalignancies of Squamous Epithelium of the Oral Cavity and Oral Pharynx Via an Adenoviral Vector [NCI Supplied Agent Ad-p53, (INGN 201) (Advexin®) NSC 683550, IND# 7135]	Completed	NCT00064103	Phase 1, Phase 2
10	Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral	Completed	NCT03638622	Phase 1, Phase 2
11	Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer	Recruiting	NCT03224000	Phase 2
12	Multimodality Therapy With Induction Carboplatin/Nab-Paclitaxel/Durvalumab Followed by Surgical Resection and Risk-adapted Adjuvant Therapy for the Treatment of Locally-Advanced and Surgically Resectable Squamous Cell Carcinoma of the Head and Neck	Recruiting	NCT03174275	Phase 2	Durvalumab;Carboplatin;Nab-paclitaxel;Cisplatin
13	Phase II Randomized Trial of Radiotherapy With or Without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) With TP53 Sequencing	Recruiting	NCT02734537	Phase 2	Cisplatin
14	A Phase I-II, FIH Study of A166 in Locally Advanced/Metastatic Solid Tumors Expressing Human Epidermal Growth Factor Receptor 2 (HER2) or Are HER2 Amplified That Did Not Respond or Stopped Responding to Approved Therapies	Recruiting	NCT03602079	Phase 1, Phase 2	A166
15	A Phase II Study of Sodium Thiosulfate (STS) for Prevention of Ototoxicity in Patients With Locally Advanced Squamous Cell Carcinoma of Head and Neck (SCCHN) Undergoing Concurrent Chemoradiation With Cisplatin	Recruiting	NCT04541355	Phase 2	Cisplatin;Sodium Thiosulfate
16	Phase II Trial of Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer	Active, not recruiting	NCT03258008	Phase 2	Utomilumab
17	Guided by Light: Optimizing Surgical Excision of Oral Cancer Using Real-time Fluorescence Imaging	Not yet recruiting	NCT04191460	Phase 2	cRGD-ZW800-1.
18	Phase I Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases	Recruiting	NCT03093909	Phase 1	Gemcitabine
19	Phase I Trial With Expansion Cohort of DNA-PK Inhibition and IMRT in Cisplatin-Ineligible Patients With Stage 3-4 Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)	Recruiting	NCT04533750	Phase 1	Peposertib
20	A Phase Ib Investigation of Pembrolizumab in Combination With Intratumoral Injection of Clostridium Novyi-NT in Patients With Treatment-Refractory Solid Tumors	Recruiting	NCT03435952	Phase 1	Pembrolizumab;Doxycycline
21	Phase I Trial of BAY1895344 ATR Inhibitor Combined With Stereotactic Body Radiation Therapy and Pembrolizumab for Recurrent Head and Neck Squamous Cell Carcinoma	Not yet recruiting	NCT04576091	Phase 1	Elimusertib
22	A Phase I Study of Alisertib and TAK-228 in Participants With Human Papilloma Virus (HPV) Associated Malignancies	Withdrawn	NCT02812056	Phase 1	Alisertib;TAK-228
23	Phase I Study of Intraarterial ONYX-015 in Combination With Intravenous Cisplatin and Fluorouracil in Patients With Advanced Squamous Cell Cancer of the Head and Neck	Withdrawn	NCT00006106	Phase 1	cisplatin;fluorouracil;ONYX-015
24	A Phase I Trial of Lenvatinib (Multi-kinase Inhibitor) and Capecitabine (Anti-metabolite) in Patients With Advanced Malignancies	Withdrawn	NCT02915172	Phase 1	Lenvatinib;Capecitabine
25	The Role of Vascular Endothelial Growth Factor-C (VEGF-C) and Its Receptors Induced Lymphangiogenesis on the Carcinogenesis of Oral Cancers and Premalignant Lesions	Unknown status	NCT00173316
26	Oral State of Patients Affected by an Oral Cancer Before and After Radiotherapy - 3-years Prospective Study	Unknown status	NCT02866500
27	Dual-time PET/CT and Sentinel Node Diagnostics Preoperatively in Patients With Oral Cancer	Unknown status	NCT01136265
28	Observational Study on the Carcinogenesis of Gα12 in Oral Cancer, and Chemopreventive Possibility for the Treatment of Oral Cancer Using Ga12 Inhibitor.	Unknown status	NCT01919580
29	Observational Study on the Carcinogenesis of SOX-9 in Oral Cancer, and Chemopreventive Possibility for the Treatment of Oral Cancer Using SOX-9 Inhibitor.	Unknown status	NCT01919567
30	Validation of DNA Methylation Biomarkers for Oral Cancer Detection-Follow up Study	Unknown status	NCT02902406
31	A Longitudinal Study of Plasma EBV DNA in Nasopharyngeal Carcinoma From Both Endemic and Non-Endemic Patient Populations	Completed	NCT00186433
32	Epstein-Barr Detection in Squamous Cell Carcinoma and Healthy Oral Mucosa	Completed	NCT01039272
33	Rehabilitation Outcomes of Shoulder Function in Oral Cancer Survivors Cancer Survivors	Completed	NCT03545100
34	Behavior Change on Oral Cancer Patients After a Localized Behavior Change Model Intervention	Completed	NCT01351532
35	Effectiveness of Green Tea Mouthwash on the Oral Health Status in Oral Cancer Patients: A Single-blind Randomized Clinical Trial and a CONSORT-compliant Article	Completed	NCT04615780
36	Using an APP in Post Oral Cancer Surgery to Affect Patients' Needs and Quality of Life.	Completed	NCT04049968
37	Validation of DNA Methylation Biomarkers for Oral Cancer Detection	Completed	NCT01945697
38	Web-based Education on Oral Cancer for Primary Care Physicians in Ohio	Completed	NCT01424358
39	Validation of DNA Methylation Biomarkers for Oral Cancer Detection	Completed	NCT02648789
40	Randomized Intervention Trial to Evaluate Oral Visual Inspection in the Control of Oral Cancer	Completed	NCT04494620
41	Retrospective Analysis Of Sensory Recovery Of Donor Size And Related Quality Life In Oral Cancer Patients Receiving Free Flap Reconstruction	Completed	NCT02048631
42	Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers	Recruiting	NCT00568490
43	Yeur-Hur Lai, PhD, RN, School of Nursing, College of Medicine, National Taiwan University	Recruiting	NCT04214912
44	Integrated Cancer Repository for Cancer Research	Recruiting	NCT02012699
45	Dyadic Yoga Intervention for Patient With Head and Neck Cancer Undergoing Radiotherapy and Their Family Caregivers	Active, not recruiting	NCT03114501
46	Correlative Study of Nicotine Levels With Response Rates to Therapy Using Radiation Alone or in Combination With Chemotherapy in Head and Neck Cancer	Active, not recruiting	NCT01084733
47	Clinical Evaluation of the OncAlert RAPID; Impact on Decision-Making	Active, not recruiting	NCT03239834
48	THE HONG KONG ORAL CANCER EDUCATION AND SCREENING (HOCES) PROGRAM: REFINING DISEASE PREVENTION, RISK STRATIFICATION AND EARLY DETECTION	Not yet recruiting	NCT04487938

Search NIH Clinical Center for Lip Cancer

Cochrane evidence based reviews: lip neoplasms

Sources

Genetic Tests for Lip Cancer

Sources

Anatomical Context for Lip Cancer

MalaCards organs/tissues related to Lip Cancer:

⁴⁰

Skin, Lymph Node, Endothelial, Tongue, Thyroid, Salivary Gland, Neutrophil

Sources

Publications for Lip Cancer

Articles related to Lip Cancer:

(show top 50) (show all 471)

#	Title	Authors	PMID	Year
1	A short review on DNA damage and repair effects in lip cancer. ⁶¹	Toprani SM...Kelkar Mane V	33626329	2021
2	The relevance of miRNAs as promising biomarkers in lip cancer. ⁶¹	Assao A...Oliveira DT	33439343	2021
3	Trends in mortality rates for oral and oropharyngeal cancer in Spain, 1979-2018. ⁶¹	Duran-Romero AJ...Pereyra-Rodriguez JJ	33305413	2020
4	Application of vermillion myocutaneous flap in restoration after lip cancer resection. ⁶¹	Li X...Yao C	32951304	2020
5	State Medicaid expansion status, insurance coverage and stage at diagnosis in head and neck cancer patients. ⁶¹	Osazuwa-Peters N...Varvares MA	32629408	2020
6	Risk of squamous cell carcinoma of the lip and cutaneous melanoma in older Australians using hydrochlorothiazide: A population-based case-control study. ⁶¹	Daniels B...Zoega H	32608576	2020
7	Immunohistochemical analysis of epithelium adjacent to lip cancer: A meta-analysis. ⁶¹	Varela-Centelles P...Seoane-Romero JM	32945581	2020
8	Predictive factors of late neck metastasis in early stage lip cancer followed by "wait and see" policy. ⁶¹	Yucel A...Yucel H	32526529	2020
9	Cancer incidence among seafarers and fishermen in the Nordic countries. ⁶¹	Ugelvig Petersen K...Hansen J	31917456	2020
10	Lower Lip Cancer Managed by Reconstruction with a Double Abbe Flap - A Case Report. ⁶¹	Sumida T...Mori Y	33708599	2020
11	Association between hydrochlorothiazide exposure and different incident skin, lip and oral cavity cancers: A series of population-based nested case-control studies. ⁶¹	Morales DR...Kurz X	32068906	2020
12	The Upper Lip Squamous Cell Carcinoma the Role of Wedge Excision. ⁶¹	Obradovic B	32068722	2020
13	Fusuma Sliding Flap for Lip Reconstruction of Lower Lip Cancer. ⁶¹	Miyazaki R...Miyake M	32209936	2020
14	Predictors of occult lymph node metastases in lip cancer. ⁶¹	Walton E...Cramer JD	32081379	2020
15	High dose rate interstitial brachytherapy for early stage lip cancer using customized dental spacer. ⁶¹	Masui K...Yamada K	32266411	2020
16	Analysis of the Filipinos' Interest in Searching Online for Oral Cancer. ⁶¹	Dalanon J...Matsuka Y	32334480	2020
17	Erratum: Facial cutaneous metastases of advanced rectal malignancy masquerading as lip cancer. ⁶¹		32270784	2020
18	Pointless spatial modeling. ⁶¹	Wilson K...Wakefield J	30202860	2020
19	A Novel Method for Reconstruction of the Lower Lip After Lip Cancer Ablation: Double Abbe Flap. ⁶¹	Chen L...Wu H	31785249	2020
20	Global patterns and trends in cancers of the lip, tongue and mouth. ⁶¹	Miranda-Filho A...Bray F	31986342	2020
21	Detection of Occult Metastases in Patients with T1 and T2 Stage Lower Lip Squamous Cell Carcinomas after Positive Lymphoscintigraphy. ⁶¹	Loxha MP...Rusinovci S	32053939	2020
22	Case report of a huge lower lip cancer successfully treated with intra-arterial infusion chemotherapy. ⁶¹	Sheen YT...Sheen MC	32446228	2020
23	Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis. ⁶¹	Santana T...Braga MM	31880283	2020
24	Use of hydrochlorothiazide and risk of skin cancer: a nationwide Taiwanese case-control study. ⁶¹	Pottegard A...Lai EC	31673105	2019
25	Predictive factors for late cervical metastasis in stage I and II squamous cell carcinoma of the lip. ⁶¹	Kavabata NK...Cernea CR	31161362	2019
26	A bibliometric analysis of the most cited articles about squamous cell carcinoma of the mouth, lips, and oropharynx. ⁶¹	Hassona Y...Qutachi T	31076327	2019
27	Cancer incidence and mortality after heart transplantation - A population-based national cohort study. ⁶¹	Jaamaa-Holmberg S...Lommi J	30821595	2019
28	The stem cell markers expression CD44v6 and podoplanin in lip cancer: clinical significance. ⁶¹	Garcia AS...Oliveira DT	30770986	2019
29	Preoperative neutrophil lymphocyte ratio but not platelet lymphocyte ratio predicts survival and early relapse in patients with oral, pharyngeal, and lip cancer. ⁶¹	Yu W...Qu X	30633409	2019
30	Impact of varying anatomic sites on advanced stage and survival of oral cancer: 9-year prospective cohort of 27 717 cases. ⁶¹	Su WW...Chen MK	30652378	2019
31	Lip cancer: Reconsidering the at-risk patients with pathological assessment. ⁶¹	Ant A...Bozdogan N	30548899	2019
32	Cancer incidence in the Agricultural Health Study after 20 years of follow-up. ⁶¹	Lerro CC...Beane Freeman LE	30805813	2019
33	Plasma cell cheilitis: the diagnosis of a disorder mimicking lip cancer. ⁶¹	Dos Santos HT...de Sousa SF	30963053	2019
34	Adjuvant interstitial three-dimensional pulse-dose-rate-brachytherapy for lip squamous cell carcinoma after surgical resection. ⁶¹	Chyrek AJ...Wojcieszek PA	31139219	2019
35	A Comparison of the NCDB and SEER Database for Research Involving Head and Neck Cancer. ⁶¹	Janz TA...Lentsch EJ	30129822	2019
36	Risk of lip cancer after solid organ transplantation in the United States. ⁶¹	Laprise C...Engels EA	30074684	2019
37	Total lower lip reconstruction by bilateral Fujimori technique-A case report. ⁶¹	Trostrup H...Hesselfeldt J	31035229	2019
38	Squamous Cell Carcinoma of Lower Lip Reconstructed with Bilateral Fan Flap. ⁶¹	Supreet BD...Patil NS	31293957	2019
39	Photosensitizing antihypertensive drug use and risk of cutaneous squamous cell carcinoma. ⁶¹	Su KA...Asgari MM	29723931	2018
40	Malignant transformation of actinic cheilitis: A systematic review of observational studies. ⁶¹	Dancyger A...Ariyawardana A	29863311	2018
41	Incidence of first and second primary cancers diagnosed among people with HIV, 1985-2013: a population-based, registry linkage study. ⁶¹	Hessol NA...Schwarcz SK	30245004	2018
42	DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF 59 PATIENTS WITH LIP CANCER AT A TERTIARY UNIVERSITY HOSPITAL IN TURKEY - A SINGLE-CENTER EXPERIENCE. ⁶¹	Miskinli R...Ozgursoy O	30618385	2018
43	Antihypertensive drugs and risk of skin cancer. ⁶¹	Cassano N...Peris K	29368863	2018
44	Lip reconstruction technique: A modified Abbe-Estlander with a myomucosal advancement flap. ⁶¹	Brabyn PJ...Rodriguez-Campo FJ	29183823	2018
45	Immunoexpression of glucocorticoid receptor alpha (GRα) isoform and apoptotic proteins (Bcl-2 and Bax) in actinic cheilitis and lower lip squamous cell carcinoma. ⁶¹	de Sena LSB...Nonaka CFW	29935090	2018
46	Cancer incidence among merchant seafarers: an extended follow-up of a Danish cohort. ⁶¹	Ugelvig Petersen K...Hansen J	29779004	2018
47	Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. ⁶¹	Custodio M...Trierveiler M	29779037	2018
48	The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma. ⁶¹	Tseng HW...Shiue YL	29630749	2018
49	Moesin Involvement in Oral Carcinogenesis of the Lower Lip. ⁶¹	Assao A...Oliveira DT	29715096	2018
50	[Incidence of type 2 diabetes among oral cancer patients in Hungary]. ⁶¹	Banyai D...Ujpal M	29754510	2018

Sources

Genes for Lip Cancer

Genes related to Lip Cancer (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TP53	Tumor Protein P53	Protein Coding	11.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	PDPN	Podoplanin	Protein Coding	10.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	MDM2	MDM2 Proto-Oncogene	Protein Coding	10.27	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	MSH2	MutS Homolog 2	Protein Coding	10.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	10.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	MIR202	MicroRNA 202	RNA Gene	7.31	DISEASES inferred ¹⁵ ¹⁵
7	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	6.27	GeneCards inferred via : Publications (show sections)
8	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	6.27	GeneCards inferred via : Publications (show sections)
9	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	6.27	GeneCards inferred via : Publications (show sections)
10	DDX60L	DExD/H-Box 60 Like	Protein Coding	6.16	DISEASES inferred ¹⁵
11	ZER1	Zyg-11 Related Cell Cycle Regulator	Protein Coding	5.41	DISEASES inferred ¹⁵
12	DDX60	DExD/H-Box Helicase 60	Protein Coding	5.14	DISEASES inferred ¹⁵

Sources

Variations for Lip Cancer

Sources

Expression for Lip Cancer

Search GEO for disease gene expression data for Lip Cancer.

Sources

Pathways for Lip Cancer

Pathways related to Lip Cancer according to GeneCards Suite gene sharing:

(show all 39)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.71	TP53 MSH2 MDM2 CDKN1A BRAF
2	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.68	TP53 MDM2 CDKN1A CD44
3	Pathways in cancer ³⁶	12.68	TP53 MSH2 MDM2 CDKN1A BRAF
4	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.55	TP53 MDM2 CDKN1A BRAF
5	Cell Cycle Checkpoints ⁶⁵ Show member pathways G2/M Checkpoints ⁶⁵	12.52	TP53 SUMO1 MDM2 CDKN1A
6	Chks in Checkpoint Regulation ⁶³ Show member pathways DNA Repair Mechanisms ⁶³ Estrogen-mediated S-Phase Entry ⁶³ G2-M Phase Transition ⁶³ Parkinson's Disease Pathway ⁶³ SREBP Proteolysis ⁶³	12.51	TP53 SUMO1 MSH2 MDM2 CDKN1A
7	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.49	TP53 MDM2 CDKN1A BRAF
8	MicroRNAs in cancer ³⁶	12.4	TP53 MDM2 CDKN1A CD44
9	DNA Damage ⁴	12.36	TP53 MSH2 MDM2 CDKN1A
10	Transcriptional misregulation in cancer ³⁶	12.14	TP53 MDM2 CDKN1A
11	p53 Signaling ⁶³ Show member pathways P53 Pathway ⁶⁶	12.12	TP53 MDM2 CDKN1A
12	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	12.11	TP53 MDM2 CDKN1A BRAF
13	Cellular senescence (KEGG) ³⁶	12.03	TP53 MDM2 CDKN1A
14	Colorectal Cancer Metastasis ⁶³	12	TP53 MSH2 CDKN1A BRAF
15	FoxO signaling pathway ³⁶ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.97	MDM2 CDKN1A BRAF
16	Proteoglycans in cancer ³⁶	11.97	TP53 MDM2 CDKN1A CD44 BRAF
17	TGF-beta Signaling Pathway (WikiPathways) ¹	11.95	TP53 SUMO1 CDKN1A
18	Integrated Breast Cancer Pathway ¹	11.95	TP53 MSH2 MDM2 BRAF
19	DNA Damage Response (only ATM dependent) ¹	11.88	TP53 MDM2 CDKN1A
20	Direct p53 effectors ¹	11.85	TP53 MSH2 MDM2 CDKN1A
21	Androgen receptor signaling pathway ¹	11.75	SUMO1 MDM2 CDKN1A
22	Glioblastoma Multiforme ⁶³	11.75	TP53 MDM2 CDKN1A BRAF
23	Retinoblastoma (RB) in Cancer ¹	11.73	TP53 MDM2 CDKN1A
24	ATM Pathway ⁶³ Show member pathways ATM Signaling Pathway ¹	11.71	TP53 MDM2 CDKN1A
25	Glucocorticoid receptor regulatory network ¹	11.67	TP53 MDM2 CDKN1A
26	Transcription_P53 signaling pathway ²³	11.53	TP53 SUMO1 MDM2 CDKN1A
27	Platinum drug resistance ³⁶	11.53	TP53 MSH2 MDM2 CDKN1A
28	Bladder cancer ³⁶ ¹	11.49	TP53 MDM2 CDKN1A BRAF
29	Proteolysis Putative SUMO-1 pathway ²³ Show member pathways DNA damage Role of SUMO in p53 regulation ²³	11.46	TP53 SUMO1 MDM2
30	Hepatitis C and Hepatocellular Carcinoma ¹	11.42	TP53 CDKN1A CD44
31	Senescence and Autophagy in Cancer ¹	11.38	TP53 MDM2 CDKN1A CD44 BRAF
32	DNA damage_ATM/ATR regulation of G1/S checkpoint ²³	11.34	TP53 MDM2 CDKN1A
33	Aurora A signaling ¹	11.17	TP53 MDM2
34	Integrated Cancer Pathway ¹	11.12	TP53 MSH2 MDM2 CDKN1A
35	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶³	11.01	TP53 MDM2
36	LncRNA-mediated mechanisms of therapeutic resistance ¹	10.71	TP53 CDKN1A
37	Sumoylation by RanBP2 regulates transcriptional repression ¹	10.67	SUMO1 MDM2
38	Transcriptional activation of cell cycle inhibitor p21 ⁶⁵ Show member pathways Transcriptional activation of p53 responsive genes ⁶⁵	10.48	TP53 CDKN1A
39	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁵	10.27	TP53 SUMO1 MDM2 CDKN1A

Sources

GO Terms for Lip Cancer

Cellular components related to Lip Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lamellipodium membrane	GO:0031258	8.96	PDPN CD44
2	nuclear body	GO:0016604	8.92	TP53 SUMO1 MDM2 CDKN1A

Biological processes related to Lip Cancer according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein stabilization	GO:0050821	9.77	TP53 SUMO1 CDKN1A
2	cell cycle arrest	GO:0007050	9.75	TP53 MSH2 CDKN1A
3	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436	9.65	ZER1 SUMO1 MDM2
4	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.61	TP53 CDKN1A
5	intrinsic apoptotic signaling pathway	GO:0097193	9.61	TP53 CDKN1A
6	positive regulation of protein export from nucleus	GO:0046827	9.59	TP53 MDM2
7	determination of adult lifespan	GO:0008340	9.58	TP53 MSH2
8	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	9.58	TP53 MDM2 CDKN1A
9	mitotic cell cycle arrest	GO:0071850	9.57	TP53 CDKN1A
10	replicative senescence	GO:0090399	9.56	TP53 CDKN1A
11	wound healing, spreading of cells	GO:0044319	9.55	PDPN CD44
12	response to hyperoxia	GO:0055093	9.54	PDPN CDKN1A
13	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO:0043518	9.52	MDM2 CD44
14	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.51	TP53 CDKN1A
15	cardiac septum morphogenesis	GO:0060411	9.49	TP53 MDM2
16	cellular response to UV-C	GO:0071494	9.46	TP53 MDM2
17	signal transduction by p53 class mediator	GO:0072331	9.43	TP53 CDKN1A
18	cellular response to gamma radiation	GO:0071480	9.43	TP53 MDM2 CDKN1A
19	regulation of lamellipodium morphogenesis	GO:2000392	9.37	PDPN CD44
20	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO:0042771	9.33	TP53 MSH2 CDKN1A
21	cellular response to actinomycin D	GO:0072717	9.32	TP53 MDM2
22	response to X-ray	GO:0010165	9.13	TP53 MSH2 CDKN1A
23	negative regulation of apoptotic process	GO:0043066	9.1	TP53 PDPN MDM2 CDKN1A CD44 BRAF

Molecular functions related to Lip Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:0019899	9.26	TP53 SUMO1 MSH2 MDM2
2	ubiquitin protein ligase binding	GO:0031625	8.92	TP53 SUMO1 MDM2 CDKN1A

Sources

Sources for Lip Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia