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MCID: LPC002
MIFTS: 53

Lip Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lip Cancer

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MalaCards integrated aliases for Lip Cancer:

Name: Lip Cancer 12 15
Lip Neoplasms 44 73
Malignant Neoplasm of Oral Aspect of Lip, Not Specified Whether Upper or Lower 12
Malignant Neoplasm of External Lip, Not Specified As Upper or Lower 12
Malignant Neoplasm of Labial Commissure of Lip 12
Malignant Neoplasm of Lower Lip, Buccal Aspect 12
Malignant Neoplasm of Lower Lip, Inner Aspect 12
Malignant Neoplasm of Vermilion Border of Lip 12
Malignant Neoplasm of Lower Lip, Oral Aspect 12
Malignant Neoplasm of Lip, Vermilion Border 12
Malignant Neoplasm of Other Sites of Lip 12
Malignant Neoplasm of Commissure of Lip 12
Malignant Neoplasm of Lip, Inner Aspect 12
Malignant Neoplasm of Lower Lip, Mucosa 12
Malignant Tumor of Lower Labial Mucosa 12
Malignant Tumour of Labial Commissure 12
Malignant Tumor of Commissure of Lip 12
Malignant Neoplasm of Lip, External 12
Malignant Tumor of Labial Mucosa 12
Malignant Tumor of the Lip 12
Malignant Neoplasm of Lip 12
Malignant Tumour of Lip 12
Malignant Tumor of Lip 12
Cancer of Lip 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Lip Cancer

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MalaCards based summary : Lip Cancer, also known as lip neoplasms, is related to actinic cheilitis and skin melanoma. An important gene associated with Lip Cancer is SUMO1 (Small Ubiquitin-Like Modifier 1), and among its related pathways/superpathways are Endometrial cancer and Glioma. The drugs Tegafur and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and brain, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and craniofacial

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Related Diseases for Lip Cancer

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Diseases in the Lip Cancer family:

Pre-Malignant Neoplasm Lip Carcinoma in Situ
in Situ Carcinoma Eye Carcinoma in Situ

Diseases related to Lip Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 actinic cheilitis 29.2 MDM2 MSH2 TP53
2 skin melanoma 28.8 BRAF MDM2 TP53
3 cheilitis 28.4 MDM2 MSH2 SUMO1 TP53
4 lower lip cancer 12.1
5 upper lip cancer 12.0
6 oral cancer 10.7
7 nasopharyngeal carcinoma 10.5
8 tongue cancer 10.4
9 oropharynx cancer 10.4
10 cerebral primitive neuroectodermal tumor 10.3 MSH2 TP53
11 keratoacanthoma 10.3 MSH2 TP53
12 intestinal benign neoplasm 10.3 MSH2 TP53
13 oral cavity cancer 10.3
14 ring chromosome 7 10.3 MDM2 TP53
15 zika virus infection 10.3 MDM2 TP53
16 familial colorectal cancer 10.3 MSH2 TP53
17 sclerosing liposarcoma 10.3 MDM2 TP53
18 periosteal osteogenic sarcoma 10.3 MDM2 TP53
19 dedifferentiated liposarcoma 10.2 MDM2 TP53
20 gliomatosis cerebri 10.2 MDM2 TP53
21 soft tissue sarcoma 10.2 MDM2 TP53
22 small cell sarcoma 10.2 MDM2 TP53
23 colorectal adenoma 10.2 MSH2 TP53
24 myxosarcoma 10.2 MDM2 TP53
25 embryonal sarcoma 10.2 MDM2 TP53
26 adult medulloblastoma 10.2 MDM2 TP53
27 hereditary breast ovarian cancer syndrome 10.2 MSH2 TP53
28 malignant mesenchymoma 10.2 MDM2 TP53
29 cellular schwannoma 10.2 MDM2 TP53
30 muscle cancer 10.2 MDM2 TP53
31 retinal cancer 10.2 MDM2 TP53
32 sensory system cancer 10.2 MDM2 TP53
33 connective tissue cancer 10.2 MDM2 TP53
34 female reproductive organ cancer 10.2 MSH2 TP53
35 ocular cancer 10.1 MDM2 TP53
36 myxoid liposarcoma 10.1 MDM2 TP53
37 grade iii astrocytoma 10.1 MDM2 TP53
38 autosomal genetic disease 10.1 MSH2 TP53
39 histiocytoma 10.1 MDM2 TP53
40 inflammatory myofibroblastic tumor 10.1 MDM2 TP53
41 pleomorphic adenoma 10.0 MDM2 TP53
42 nevus of ota 10.0 BRAF TP53
43 hyperplastic polyposis syndrome 10.0 BRAF TP53
44 spitz nevus 10.0 BRAF TP53
45 mature teratoma 10.0 BRAF TP53
46 nervous system cancer 10.0 MDM2 TP53
47 pleomorphic xanthoastrocytoma 10.0 BRAF TP53
48 brain stem glioma 10.0 BRAF TP53
49 rectal neoplasm 10.0 MSH2 TP53
50 skin squamous cell carcinoma 10.0 BRAF TP53

Graphical network of the top 20 diseases related to Lip Cancer:



Diseases related to Lip Cancer
Sources

Symptoms & Phenotypes for Lip Cancer

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GenomeRNAi Phenotypes related to Lip Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 MSH2 SUMO1 TP53 BRAF MDM2

MGI Mouse Phenotypes related to Lip Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.56 BRAF MDM2 SUMO1 TP53
2 digestive/alimentary MP:0005381 9.55 MDM2 MSH2 SUMO1 TP53 BRAF
3 neoplasm MP:0002006 9.26 MDM2 MSH2 TP53 BRAF
4 pigmentation MP:0001186 8.8 BRAF MDM2 TP53
Sources

Drugs & Therapeutics for Lip Cancer

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Drugs for Lip Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 277)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tegafur Approved, Investigational Phase 3,Phase 2 17902-23-7 5386
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
4
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
5
Paclitaxel Approved, Vet_approved Phase 3,Phase 1,Phase 2 33069-62-4 36314
6
Cetuximab Approved Phase 3,Phase 2,Phase 1,Not Applicable 205923-56-4 56842117 2333
7
Docetaxel Approved, Investigational Phase 3,Phase 2,Phase 1 114977-28-5 148124
8
Epinephrine Approved, Vet_approved Phase 3,Phase 2 51-43-4 5816
9
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
10
Aldesleukin Approved Phase 3,Phase 2,Not Applicable 85898-30-2, 110942-02-4
11
Epirubicin Approved Phase 3,Phase 2,Phase 1 56420-45-2 41867
12
Racepinephrine Approved Phase 3,Phase 2 329-65-7 838
13
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
14
Isotretinoin Approved Phase 3,Phase 2 4759-48-2 5538 5282379
15
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
16
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
17
Fluconazole Approved, Investigational Phase 2, Phase 3 86386-73-4 3365
18
Cevimeline Approved Phase 3 107233-08-9 83898 25137844
19
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 22916-47-8 4189
20
Megestrol acetate Approved, Investigational, Vet_approved Phase 3 595-33-5 11683
21
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
22
Doxepin Approved, Investigational Phase 3 1668-19-5 667477 667468
23
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
24
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
25
Levoleucovorin Approved, Investigational Phase 3,Phase 2 68538-85-2
26
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
27
Tocopherol Approved, Investigational, Nutraceutical Phase 3 1406-66-2 14986
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
29
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
30 Porfiromycin Investigational Phase 3 801-52-5
31 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
32
Cobalt Phase 3 7440-48-4 104729
33 calcium heparin Phase 3
34 Interleukin-2 Phase 3,Phase 2
35 Analgesics Phase 3,Phase 1,Phase 2
36
s 1 (combination) Phase 3,Phase 2
37 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
38 Respiratory System Agents Phase 3,Phase 2,Not Applicable
39 Adrenergic Agents Phase 3,Phase 2
40 Adrenergic Agonists Phase 3,Phase 2
41 Adrenergic alpha-Agonists Phase 3,Phase 2
42 Mitogens Phase 3,Phase 2,Phase 1
43 Adrenergic beta-Agonists Phase 3,Phase 2
44 Albumin-Bound Paclitaxel Phase 3,Phase 1,Phase 2
45 Mydriatics Phase 3,Phase 2
46 Coagulants Phase 3
47 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
48 Hemostatics Phase 3
49 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
50 Tolonium Chloride Phase 3

Interventional clinical trials:

(show top 50) (show all 317)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip Completed NCT00868088 Phase 4
2 The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor Recruiting NCT03017053 Phase 4
3 Surgery and Radiation Therapy With or Without Chemotherapy in Treating Patients With Mouth Cancer Unknown status NCT00002747 Phase 3 cisplatin;fluorouracil
4 Surgery and Radiation Therapy With or Without Interleukin-2 in Treating Patients With Cancer of the Mouth or Oropharynx Unknown status NCT00002702 Phase 3
5 PET/CT Scan-Guided Watchful Waiting or Neck Dissection of Locally Advanced Lymph Node Metastases in Treating Patients Undergoing Chemotherapy and Radiation Therapy for Primary Head And Neck Cancer Unknown status NCT00720070 Phase 3
6 S-1 or Tegafur-Uracil in Treating Patients With Previously Treated Stage III or Stage IV Head and Neck Cancer Unknown status NCT00336947 Phase 3 tegafur-gimeracil-oteracil potassium;tegafur-uracil
7 Cisplatin Plus Epinephrine in Treating Patients With Recurrent or Refractory Head and Neck Cancer Unknown status NCT00002659 Phase 3 cisplatin-e therapeutic implant
8 Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL Unknown status NCT01039298 Phase 3
9 Oral Cancer Screening in Mumbai, India by Primary Health Care Workers Unknown status NCT00655421 Phase 3
10 Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Completed NCT01156142 Phase 3 doxepin hydrochloride
11 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
12 Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer Completed NCT00090337 Phase 3
13 Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer Completed NCT00002533 Phase 2, Phase 3 fluconazole
14 Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer Completed NCT00017511 Phase 3 cevimeline hydrochloride
15 Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer Completed NCT00006799 Phase 3 megestrol acetate
16 Radiation Therapy and Chemotherapy in Treating Patients With Head and Neck Cancer Completed NCT00002507 Phase 3 mitomycin C;porfiromycin
17 Oral Mucositis in Patients Receiving Radiation Therapy for Cancer of the Mouth, Pharynx, or Larynx Completed NCT00004234 Phase 3
18 Radiation Therapy With or Without Epoetin Alfa in Treating Anemic Patients With Head and Neck Cancer Completed NCT00004917 Phase 3 cisplatin
19 Radiation Therapy in Treating Patients With Head and Neck Cancer Completed NCT00021125 Phase 3
20 Combination Chemotherapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00002888 Phase 3 cisplatin;fluorouracil;paclitaxel
21 Radiation Therapy With or Without Chemotherapy in Treating Patients With Head and Neck Cancer That Has Been Removed During Surgery Completed NCT00002670 Phase 3 chemotherapy;cisplatin
22 Phase II Trial of Allovectin-7® for Head and Neck Cancer Completed NCT00050388 Phase 3
23 Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00002476 Phase 3 fluorouracil;leucovorin calcium;methotrexate;vincristine sulfate
24 Cisplatin With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic or Recurrent Head and Neck Cancer Completed NCT00003809 Phase 3 cisplatin
25 Fractionated Radiation Therapy in Treating Advanced Squamous Cell Carcinoma of the Head and Neck Completed NCT00771641 Phase 3
26 Radiation Therapy Plus Porfiromycin in Treating Patients With Stage III or Stage IV Head and Neck Cancer Completed NCT00003328 Phase 3 porfiromycin
27 Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Head and Neck Cancer Completed NCT00002654 Phase 3 chemotherapy;cisplatin
28 High-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With Head and Neck Cancer Completed NCT00002555 Phase 3 cisplatin
29 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer Completed NCT00003888 Phase 3 cisplatin;docetaxel;fluorouracil
30 Biafine Cream to Reduce Side Effects of Radiation Therapy in Patients Receiving Treatment for Advanced Head and Neck Cancer Completed NCT00006481 Phase 3 Biafine cream
31 Isotretinoin, Interferon Alfa, and Vitamin E in Treating Patients With Stage III or Stage IV Head and Neck Cancer Completed NCT00054561 Phase 3 isotretinoin
32 Surgery and Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer That Can Be Removed During Surgery Completed NCT00003576 Phase 3 cisplatin;fluorouracil
33 Radiation Therapy Cisplatin With or Without Fluorouracil Patients With Stage III or Stage IV Head and Neck Cancer Completed NCT00608205 Phase 3 cisplatin;fluorouracil
34 Combination Chemotherapy and Radiation in Treating Patients With Stage III or IV Head and Neck Cancer (Paradigm Trial) Completed NCT00095875 Phase 3 carboplatin;cisplatin;docetaxel;fluorouracil
35 Methotrexate Compared With Paclitaxel in Treating Patients With Advanced Head and Neck Cancer Completed NCT00003592 Phase 3 methotrexate;paclitaxel
36 Radiation Therapy and Cisplatin or Panitumumab in Treating Patients With Locally Advanced Stage III or Stage IV Head and Neck Cancer Completed NCT00820248 Phase 3 cisplatin
37 Workplace Tobacco Cessation And Oral Cancer Screening Study Completed NCT00750503 Phase 3
38 Radiation Therapy With Cisplatin, Docetaxel, or Cetuximab After Surgery in Treating Patients With Stage III-IV Squamous Cell Head and Neck Cancer Active, not recruiting NCT01810913 Phase 2, Phase 3 cisplatin;docetaxel
39 Radiation Therapy With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer Active, not recruiting NCT00956007 Phase 3
40 Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Head and Neck Cancer Active, not recruiting NCT00047008 Phase 3 cisplatin
41 Erlotinib Prevention of Oral Cancer (EPOC) Active, not recruiting NCT00402779 Phase 3 Erlotinib;Placebo
42 Radiation Therapy With or Without Epoetin Alfa in Treating Patients With Head and Neck Cancer Terminated NCT00017277 Phase 3
43 S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat Terminated NCT00006994 Phase 3 l-glutamine placebo
44 Palifermin in Lessening Oral Mucositis in Patients Undergoing Radiation Therapy and Chemotherapy for Locally Advanced Head and Neck Cancer Terminated NCT00360971 Phase 3 cisplatin
45 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery Terminated NCT00113399 Phase 3 cisplatin;docetaxel;fluorouracil;paclitaxel
46 Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery Withdrawn NCT00041171 Phase 3 Hypericum perforatum;docetaxel
47 CD2 Lozenges in Preventing Acute Oral Mucositis in Patients With Head and Neck Cancer Receiving Radiotherapy and Chemotherapy Withdrawn NCT01545687 Phase 3
48 Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients Who Have Undergone Surgery for Advanced Hypopharyngeal Cancer, Oropharyngeal Cancer, Laryngeal Cancer, or Oral Cavity Cancer at High Risk of Recurrence Withdrawn NCT01142414 Phase 3 cisplatin;fluorouracil
49 Phase II Study of Concurrent C225, Cisplatin and Radiation in Stage IV Squamous Cell Carcinoma of the Head and Neck Unknown status NCT00096174 Phase 2 cisplatin
50 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Head and Neck Cancer Unknown status NCT00006051 Phase 2 cisplatin;fluorouracil

Search NIH Clinical Center for Lip Cancer

Cochrane evidence based reviews: lip neoplasms

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Genetic Tests for Lip Cancer

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Anatomical Context for Lip Cancer

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MalaCards organs/tissues related to Lip Cancer:

41
Lung, Liver, Brain, Lymph Node, Skin, Kidney, Breast
Sources

Publications for Lip Cancer

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Articles related to Lip Cancer:

(show top 50) (show all 110)
# Title Authors Year
1
Expression of cancer stem cell markers CD44, ALDH1 and p75NTR in actinic cheilitis and lip cancer. ( 29779037 )
2018
2
Neglected Under Lip Cancer. ( 29483993 )
2018
3
AHNS Series - Do you know your guidelines? Lip cancer. ( 28580768 )
2017
4
Clinicopathological study of lip cancer: a retrospective hospital-based study in Taiwan. ( 28913905 )
2017
5
Changes in the Incidence of Skin and Lip Cancer Between 1978 and 2007. ( 28190452 )
2017
6
Hydrochlorothiazide use is strongly associated with risk of lip cancer. ( 28480532 )
2017
7
Intraoral stents in preventing adverse radiotherapeutic effects in lip cancer patients. ( 28883766 )
2017
8
Stage is a prognostic factor for surgically treated patients with early-stage lip cancer for whom a 'wait and see' policy in terms of neck status has been implemented. ( 28807064 )
2017
9
Two-Piece Extraoral Prosthetic Rehabilitation to a Perineural Invasion Lip Cancer. ( 27517479 )
2016
10
Podoplanin, ezrin, and Rho-A proteins may have joint participation in tumor invasion of lip cancer. ( 27628318 )
2016
11
Lip cancer: A 16-year retrospective epidemiological study in Eastern part of Turkey. ( 27812062 )
2016
12
Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer. ( 26842232 )
2016
13
Lip Cancer: A Clinicopathological Study and Treatment Outcomes in a 25-Year Experience. ( 26917204 )
2016
14
Oral cavity and lip cancer: United Kingdom National Multidisciplinary Guidelines. ( 27841120 )
2016
15
High azathioprine dose and lip cancer risk in liver, heart, and lung transplant recipients: A population-based cohort study. ( 26830865 )
2016
16
Lip cancer and pre-cancerous lesions harbor TP53 mutations, exhibit allelic loss at 9p, 9q, and 17p, but no BRAFV600E mutations. ( 26084614 )
2015
17
Prediction model for lymph node metastasis and recommendations for elective neck dissection in lip cancer. ( 25753473 )
2015
18
The pattern of lip cancer occurrence over the 1990-2011 period in public hospitals in Madrid, Spain. ( 26256568 )
2015
19
Oral and lip cancer in solid organ transplant patients--a cohort study from a Swedish Transplant Centre. ( 25497104 )
2015
20
Long-term outcome and subjective quality of life after surgical treatment of lower lip cancer. ( 25261402 )
2014
21
Early diagnosis of lip cancer preceded by a persistent actinic lesion in a kidney transplant patient: a case report. ( 24983181 )
2014
22
Quantification of the Surgical Margin Shrinkage in Lip Cancer: Determining the Relation Between the Surgical and Histopathologic Margins. ( 25329844 )
2014
23
Facial cutaneous metastases of advanced rectal malignancy masquerading as lip cancer. ( 25370567 )
2014
24
Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer. ( 25241153 )
2014
25
Technique for histological control of surgical margins in lip cancer. ( 24611955 )
2014
26
Pulsed dose rate brachytherapy of lip cancer. ( 24143149 )
2013
27
Antihypertensive drugs and lip cancer in non-Hispanic whites. ( 22869299 )
2012
28
High dose-rate versus low dose-rate brachytherapy for lip cancer. ( 22099044 )
2012
29
Lip cancer: a 10-year retrospective epidemiological study. ( 22493399 )
2012
30
Lip cancer: retrospective analysis of 181 cases. ( 22136191 )
2012
31
Wave technique for treatment of lower lip cancer. ( 22440315 )
2012
32
Sun protection for all: but especially for those receiving certain hypertensive medications: comment on "Antihypertensive drugs and lip cancer in non-Hispanic whites". ( 22869333 )
2012
33
High-dose-rate interstitial brachytherapy in early stage buccal mucosa and lip cancer: report on 12 consecutive patients and review of the literature. ( 23052164 )
2012
34
Surgical management of lip cancer. ( 21808457 )
2011
35
Lip cancer in renal transplant patients. ( 21112239 )
2011
36
Long term results of PDR brachytherapy for lip cancer. ( 27895671 )
2011
37
Occupational exposure to the sun and risk of skin and lip cancer among male wage earners in Denmark: a population-based case-control study. ( 20383781 )
2010
38
Lip cancer: incidence, trends, histology and survival: 1970-2006. ( 20163415 )
2010
39
Lip cancer: a 5-year review in a tertiary referral centre. ( 20129833 )
2010
40
Surgical treatment of lip cancer: our experience with 106 cases. ( 19304043 )
2009
41
Lip cancer in Western Australia, 1982-2006: a 25-year retrospective epidemiological study. ( 19473154 )
2009
42
Is elective neck dissection in T1-2, N0 patients with lower lip cancer necessary? ( 19325341 )
2009
43
Immunosuppression and other risk factors for lip cancer after kidney transplantation. ( 19190169 )
2009
44
Survival after lip cancer diagnosis. ( 19165039 )
2009
45
Sentinel lymph node biopsy (SLNB) in management of N0 stage T1-T2 lip cancer as a "same day" procedure. ( 17936674 )
2008
46
Comparison of time trends in lip cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents, Vols IV-VIII. ( 18573854 )
2008
47
L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers. ( 18645122 )
2008
48
Continuous intraarterial infusion chemotherapy for early lip cancer. ( 17207655 )
2007
49
Brachytherapy in lip cancer. ( 16648757 )
2006
50
Effectiveness of brachytherapy in the treatment of lip cancer: a retrospective study at the istanbul university oncology institute. ( 16418146 )
2005
Sources

Variations for Lip Cancer

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Expression for Lip Cancer

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Search GEO for disease gene expression data for Lip Cancer.
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Pathways for Lip Cancer

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Pathways related to Lip Cancer according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Endometrial cancer 37
Show member pathways
 12.57 BRAF MDM2 MSH2 TP53
2
Glioma 37
Show member pathways
 12.5 BRAF MDM2 TP53
3
Pathways in cancer 37
12.5 BRAF MDM2 MSH2 TP53
4
4-1BB Pathway 64
Show member pathways
 12.4 BRAF SUMO1 TP53
5
Cell Cycle Checkpoints 66
Show member pathways
 12.38 MDM2 SUMO1 TP53
6
SUMOylation 66
Show member pathways
 12.33 MDM2 SUMO1 TP53
7
Chks in Checkpoint Regulation 64
Show member pathways
 12.31 MDM2 MSH2 SUMO1 TP53
8
Development EGFR signaling pathway 22
Show member pathways
 12.27 BRAF MDM2 TP53
9
DNA Damage 4
12.25 MDM2 MSH2 TP53
10
ErbB signaling pathway 1 37
Show member pathways
 12.21 BRAF MDM2 TP53
11
Proteoglycans in cancer 37
12.04 BRAF MDM2 TP53
12
Colorectal Cancer Metastasis 64
11.93 BRAF MSH2 TP53
13
SMAD Signaling Network 64
11.81 MDM2 SUMO1 TP53
14
Direct p53 effectors 1
11.79 MDM2 MSH2 TP53
15
Glioblastoma Multiforme 64
11.68 BRAF MDM2 TP53
16
Senescence and Autophagy in Cancer 1
11.63 BRAF MDM2 TP53
17
BRCA1 Pathway 64
Show member pathways
 11.58 MSH2 TP53
18
Glucocorticoid receptor regulatory network 1
11.57 MDM2 TP53
19
Regulation of TP53 Expression and Degradation 66
Show member pathways
 11.52 MDM2 TP53
20
Integrated Breast Cancer Pathway 1
11.44 BRAF MDM2 MSH2 TP53
21
p53 pathway 1
11.42 MDM2 TP53
22
Bladder cancer 37 1
11.41 BRAF MDM2 TP53
23
Copper homeostasis 1
11.37 MDM2 TP53
24
HIF1Alpha Pathway 64
11.37 MDM2 TP53
25
Platinum drug resistance 37
11.36 MDM2 MSH2 TP53
26
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.26 MDM2 TP53
27
Doxorubicin Pathway, Pharmacokinetics 61
Show member pathways
 11.21 MSH2 TP53
28
Proteolysis Putative SUMO-1 pathway 22
Show member pathways
 11.17 MDM2 SUMO1 TP53
29
Oncogene Induced Senescence 66
11.09 MDM2 TP53
30
Aurora A signaling 1
11.07 MDM2 TP53
31
Integrated Cancer Pathway 1
10.99 MDM2 MSH2 TP53
32
Inhibition of Ribosome Biogenesis by p14(ARF) 64
10.91 MDM2 TP53
33
Sumoylation by RanBP2 regulates transcriptional repression 1
10.55 MDM2 SUMO1
34
TP53 Network 1
Show member pathways
 10.14 MDM2 SUMO1 TP53
Sources

GO Terms for Lip Cancer

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Cellular components related to Lip Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear body GO:0016604 8.8 MDM2 SUMO1 TP53

Biological processes related to Lip Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.65 MDM2 SUMO1 TP53
2 positive regulation of gene expression GO:0010628 9.61 BRAF MDM2 TP53
3 protein sumoylation GO:0016925 9.52 MDM2 SUMO1
4 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.51 MDM2 SUMO1
5 cellular response to drug GO:0035690 9.49 BRAF TP53
6 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.46 MDM2 TP53
7 response to antibiotic GO:0046677 9.4 MDM2 TP53
8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.37 MSH2 TP53
9 cellular response to gamma radiation GO:0071480 9.32 MDM2 TP53
10 response to X-ray GO:0010165 9.26 MSH2 TP53
11 positive regulation of protein export from nucleus GO:0046827 9.16 MDM2 TP53
12 determination of adult lifespan GO:0008340 8.96 MSH2 TP53
13 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Lip Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.43 MDM2 SUMO1 TP53
2 p53 binding GO:0002039 9.37 MDM2 TP53
3 damaged DNA binding GO:0003684 9.32 MSH2 TP53
4 disordered domain specific binding GO:0097718 9.16 MDM2 TP53
5 SUMO transferase activity GO:0019789 8.96 MDM2 SUMO1
6 enzyme binding GO:0019899 8.92 MDM2 MSH2 SUMO1 TP53
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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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