|
MCID: LPD026
MIFTS: 30
|
Lipedema
Categories:
Rare diseases, Skin diseases
|
|
|
|
MalaCards integrated aliases for Lipedema:Characteristics:Orphanet epidemiological data:60
lipedema
Prevalence: 1-9/100000 (United Kingdom),1-9/100000 (Europe); OMIM:58
Inheritance:
autosomal dominant
Miscellaneous:
virtually all patients with this condition are female torso and upper body remain normal in shape and contour feet are unaffected HPO:33Classifications:
ICD10:
35
|
|
NIH Rare Diseases
:
54
Lipedema is a disorder characterized by symmetric enlargement of the legs due to deposits of fat beneath the skin. It is a common condition, occurring almost exclusively in women (affecting up to 11% of women). The cause of lipedema is unknown; however, there is evidence of hormonal and hereditary influences. Many people with lipedema have a family history of similarly enlarged legs. While there is no one effective treatment for lipedema, a number of therapies may be useful in managing symptoms.
MalaCards based summary : Lipedema is related to lymphedema and sotos syndrome 1. An important gene associated with Lipedema is NSD1 (Nuclear Receptor Binding SET Domain Protein 1). The drugs Hormones and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and adipocyte, and related phenotypes are lipodystrophy and pedal edema OMIM : 58 Lipedema is a disorder of adipose tissue characterized by fat legs and orthostatic edema. Characteristically, the buttocks and other parts of the lower extremities are symmetrically enlarged owing to accumulation of excess fat and fluid. The condition affects women almost exclusively and, in most instances, represents an exaggeration of the female form (summary by Hines, 1952). (614103) Wikipedia : 77 Lipedema is a disorder where there is enlargement of both legs due to deposits of fat under the skin.... more... |
Diseases related to Lipedema via text searches within MalaCards or GeneCards Suite gene sharing:(show all 13)
Graphical network of the top 20 diseases related to Lipedema:
|
Human phenotypes related to Lipedema:60 33
Symptoms via clinical synopsis from OMIM:58Clinical features from OMIM:614103 |
Drugs for Lipedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
Interventional clinical trials:(show all 11)
|
MalaCards organs/tissues related to Lipedema:42
Skin,
Bone,
Adipocyte
|
Articles related to Lipedema:(show top 50) (show all 68)
|
Genes related to Lipedema (0 elite genes): - Elite gene
- Cancer Census gene in COSMIC
|
ClinVar genetic disease variations for Lipedema:6
|
|
|
|