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MCID: LPD008
MIFTS: 61

Lipid Metabolism Disorder

Categories: Metabolic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Lipid Metabolism Disorder

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MalaCards integrated aliases for Lipid Metabolism Disorder:

Name: Lipid Metabolism Disorder 12 15
Dyslipidemia 12 54 15
Disorder of Fatty Acid Metabolism 29 70
Abnormality of Lipid Metabolism 29 6
Lipid Metabolism Disorders 42 70
Lipid Metabolism, Inborn Errors 44
Fatty Acid Metabolism Disorder 12
Disorder of Lipid Metabolism 58
Dyslipidemias 70

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Inborn errors of metabolism


External Ids:

Disease Ontology 12 DOID:3146
MeSH 44 D008052
ICD10 32 E71.3
UMLS via Orphanet 71 C0154251
Orphanet 58 ORPHA309005
UMLS 70 C0023772 C0154251 C0242339 more
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Summaries for Lipid Metabolism Disorder

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MedlinePlus : 42 Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues. If you have a metabolic disorder, something goes wrong with this process. Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease, involve lipids. Lipids are fats or fat-like substances. They include oils, fatty acids, waxes, and cholesterol. If you have one of these disorders, you may not have enough enzymes to break down lipids. Or the enzymes may not work properly and your body can't convert the fats into energy. They cause a harmful amount of lipids to build up in your body. Over time, that can damage your cells and tissues, especially in the brain, peripheral nervous system, liver, spleen, and bone marrow. Many of these disorders can be very serious, or sometimes even fatal. These disorders are inherited. Newborn babies get screened for some of them, using blood tests. If there is a family history of one of these disorders, parents can get genetic testing to see whether they carry the gene. Other genetic tests can tell whether the fetus has the disorder or carries the gene for the disorder. Enzyme replacement therapies can help with a few of these disorders. For others, there is no treatment. Medicines, blood transfusions, and other procedures may help with complications.

MalaCards based summary : Lipid Metabolism Disorder, also known as dyslipidemia, is related to hypobetalipoproteinemia, familial, 1 and chylomicron retention disease. An important gene associated with Lipid Metabolism Disorder is FADS1 (Fatty Acid Desaturase 1), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The drugs Tocopherol and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and kidney, and related phenotypes are Decreased free cholesterol and Decreased LDL uptake

Disease Ontology : 12 An inherited metabolic disorder that involves the creation and degradation of lipids.

Wikipedia : 73 Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown or storage... more...

Sources

Related Diseases for Lipid Metabolism Disorder

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Diseases related to Lipid Metabolism Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 672)
# Related Disease Score Top Affiliating Genes
1 hypobetalipoproteinemia, familial, 1 32.6 MTTP APOE APOC3 APOB APOA5 APOA1
2 chylomicron retention disease 32.3 MTTP APOB APOA1
3 lipodystrophy, familial partial, type 2 32.3 PPARG PPARA LEP INS ADIPOQ
4 hyperlipoproteinemia, type iii 32.1 LPL LIPC HMGCR CETP APOE APOB
5 hypolipoproteinemia 32.0 MTTP LPL CETP APOE APOC3 APOB
6 hypercholesterolemia, familial, 1 32.0 LPL LIPC INS HMGCR CRP CETP
7 hypertriglyceridemia, familial 32.0 SERPINE1 LPL LIPC INS CETP APOE
8 abdominal obesity-metabolic syndrome 1 31.9 SERPINE1 RETN PPARG PPARA LPL LEP
9 prediabetes syndrome 31.9 SERPINE1 RETN PPARG LEP INS CRP
10 hyperglycemia 31.6 SERPINE1 RETN PPARG LPL LEP INS
11 hyperinsulinism 31.5 SERPINE1 RETN PPARG PPARA LPL LEP
12 liver disease 31.5 RETN PPARA MTTP LEP INS ADIPOQ
13 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 31.4 PPARG LEP INS ADIPOQ
14 polycystic ovary syndrome 31.4 RETN PPARG LEP INS ADIPOQ
15 arteries, anomalies of 31.3 SERPINE1 LEP INS CRP APOE APOB
16 end stage renal disease 31.2 LEP INS CRP APOB ADIPOQ ACE
17 atherosclerosis susceptibility 31.2 SERPINE1 RETN PPARG PPARA LPL LIPC
18 chronic kidney disease 31.2 SERPINE1 RETN PPARG LPL LIPC LEP
19 nephrotic syndrome 31.1 LPL HMGCR CRP CETP APOE APOB
20 homozygous familial hypercholesterolemia 31.1 LIPC HMGCR APOE APOB APOA1
21 familial hypercholesterolemia 31.1 SERPINE1 MTTP LPL LIPC LEP INS
22 fatty liver disease 31.1 SERPINE1 RETN PPARG PPARA MTTP LEP
23 peripheral vascular disease 31.0 SERPINE1 HMGCR CRP CETP APOB APOA1
24 gestational diabetes 31.0 RETN PPARG LEP INS CRP ADIPOQ
25 cerebrovascular disease 31.0 SERPINE1 RETN LPL LEP INS CRP
26 pre-eclampsia 31.0 SERPINE1 LEP INS CRP ADIPOQ ACE
27 hyperandrogenism 31.0 PPARG INS ADIPOQ
28 body mass index quantitative trait locus 11 31.0 SERPINE1 RETN PPARG PPARA MTTP LPL
29 sleep apnea 31.0 SERPINE1 RETN LEP INS CRP APOE
30 stroke, ischemic 31.0 SERPINE1 HMGCR CRP APOE APOB ACE
31 type 1 diabetes mellitus 30.9 RETN LEP INS CRP CETP APOB
32 kidney disease 30.9 SERPINE1 RETN PPARG LEP INS HMGCR
33 vascular disease 30.9 SERPINE1 RETN PPARG LPL LIPC LEP
34 hyperlipidemia, familial combined, 3 30.9 PPARA LPL LIPC INS HMGCR CETP
35 arteriosclerosis 30.9 SERPINE1 PPARG PPARA INS HMGCR CRP
36 uremia 30.9 RETN LPL LEP INS CRP APOC3
37 hyperthyroidism 30.9 RETN LEP INS CRP
38 peripheral artery disease 30.9 RETN LEP CRP APOE APOB APOA1
39 lipoprotein quantitative trait locus 30.9 SERPINE1 RETN PPARG PPARA LPL LIPC
40 acute pancreatitis 30.8 RETN LPL INS CRP
41 anovulation 30.8 LEP INS CRP
42 heart disease 30.8 SERPINE1 RETN PPARG PPARA LPL LEP
43 acute myocardial infarction 30.8 SERPINE1 HMGCR CRP APOB APOA1 ACE
44 homocysteinemia 30.8 SERPINE1 CRP APOE
45 sitosterolemia 30.8 MTTP HMGCR APOB APOA5 APOA1
46 eye disease 30.7 PPARA INS HMGCR CRP APOA1
47 hypoalphalipoproteinemia 30.7 LIPC APOA1
48 aortic aneurysm, familial abdominal, 1 30.7 SERPINE1 CRP CETP APOE ACE
49 diabetic neuropathy 30.7 LEP INS ACE
50 chlamydia pneumonia 30.7 PPARG CRP APOE

Comorbidity relations with Lipid Metabolism Disorder via Phenotypic Disease Network (PDN):


Hypertension, Essential Intermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Lipid Metabolism Disorder:



Diseases related to Lipid Metabolism Disorder
Sources

Symptoms & Phenotypes for Lipid Metabolism Disorder

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GenomeRNAi Phenotypes related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.65 LIPC
2 Decreased LDL uptake GR00340-A-1 8.32 LPL

MGI Mouse Phenotypes related to Lipid Metabolism Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.32 ACE ADIPOQ APOA1 APOA5 APOB APOE
2 cardiovascular system MP:0005385 10.27 ACE ADIPOQ APOA1 APOB APOE CRP
3 growth/size/body region MP:0005378 10.22 ACE ADIPOQ APOB APOE FADS1 HMGCR
4 adipose tissue MP:0005375 10.18 ACE ADIPOQ APOE INS LEP LPL
5 cellular MP:0005384 10.17 ADIPOQ APOA1 APOB APOE FADS1 HMGCR
6 immune system MP:0005387 10.1 ACE ADIPOQ APOB APOE CRP FADS1
7 liver/biliary system MP:0005370 10 ACE ADIPOQ APOA1 APOB APOE HMGCR
8 integument MP:0010771 9.91 ADIPOQ APOA1 APOE INS LEP LPL
9 muscle MP:0005369 9.56 ADIPOQ APOB APOE INS LEP LPL
10 renal/urinary system MP:0005367 9.28 ACE ADIPOQ APOE FADS1 INS LEP
Sources

Drugs & Therapeutics for Lipid Metabolism Disorder

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Drugs for Lipid Metabolism Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 331)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2
2
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
3
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
4
Bilberry Approved, Experimental Phase 4
5
Metformin Approved Phase 4 657-24-9 4091 14219
6
Nateglinide Approved, Investigational Phase 4 105816-04-4 60026
7
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
8
Pravastatin Approved Phase 4 81093-37-0 54687
9
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
10
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
11
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
12
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
13
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
14
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
15
Sirolimus Approved, Investigational Phase 4 53123-88-9 6436030 5284616
16
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
17
Bezafibrate Approved, Investigational Phase 4 41859-67-0 39042
18
Zidovudine Approved Phase 4 30516-87-1 35370
19
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
20
deoxycholic acid Approved Phase 4 83-44-3 222528
21
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
22
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
23
Losartan Approved Phase 4 114798-26-4 3961
24
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
25
Nevirapine Approved Phase 4 129618-40-2 4463
26
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
27 Orange Approved Phase 4
28
Ciprofibrate Approved, Investigational Phase 4 52214-84-3 2763
29
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
30
Lopinavir Approved Phase 4 192725-17-0 92727
31
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
32
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
33
Calcium polycarbophil Approved Phase 4 126040-58-2
34
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
35 Coconut Approved Phase 4
36
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 130881 158781
37
Empagliflozin Approved Phase 4 864070-44-0
38
Fenofibrate Approved Phase 4 49562-28-9 3339
39
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
40
Evolocumab Approved Phase 4 1256937-27-5
41 Fenofibric acid Approved Phase 4 42017-89-0
42
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
43
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
44
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
45
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
46
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
47 Tocotrienol Investigational Phase 4 6829-55-6
48
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
49
Candesartan Experimental Phase 4 139481-59-7 2541
50
Cobalamin Experimental Phase 4 13408-78-1 6857388

Interventional clinical trials:

(show top 50) (show all 974)
# Name Status NCT ID Phase Drugs
1 An Open-Label Extension of a Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate Simvastatin 20 mg Plus Omacor 4g Compared to Simvastatin 20 mg Plus Placebo in Subjects With Mixed Dyslipidemia Unknown status NCT00678743 Phase 4 Omacor + simvastatin
2 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT)-A Randomized Controlled Trial Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
3 Effects of Dapagliflozin on Hyperlipidemia, Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients (DAPHNIS Study) Unknown status NCT02577159 Phase 4 Dapagliflozin
4 Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients Unknown status NCT02933788 Phase 4 Cilostazol;Acetylsalicylic acid
5 A Multi-center, Randomized, Double-blind, Parallel Phase â…£ Study to Explore the Efficacy of Statin/Choline Fenofibrate Combination Therapy vs Statin Monotherapy in Patients With Inadequately Controlled TG Despite Receiving Statin Monotherapy Unknown status NCT03874260 Phase 4 Fenofibrate
6 A Multi-center, Randomized, Parallel Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Triple Therapy of Telmisartan/Amlodipine/Rosuvastatin in Patients With Dyslipidemia and Hypertension Unknown status NCT03860220 Phase 4 NEWSTATIN TS;CADUET
7 Study on the Efficacy aNd Safety of Jinlida Granules in Patients With Inadequately cOntrolled tYpe-2 Diabetes and dysLIpidemia Under liFe Style Intervention (ENJOY LIFE Study) Unknown status NCT02035644 Phase 4 Jinlida granules;placebo granules
8 Reversal of Antipsychotic-Induced Hyperprolactinemia, Weight Gain, Hyperglycemia and Dyslipidemia by Aripiprazole Add-on Therapy in the Treatment of Schizophrenia and Bipolar Disorder: An Open-Label Trial Unknown status NCT00541554 Phase 4 Abilify (aripiprazole)
9 Comparison of High-Dose Rosuvastatin Versus Low Statin Dose Plus Fenofibrate Versus Low Statin Dose Plus Niacin in the Treatment of Mixed Hyperlipidemia Unknown status NCT01010516 Phase 4 High-dose rosuvastatin;Statin plus fenofibrate;Statin plus niacin ER/laropiprant
10 An Open-label, Randomized, Multi-centre, Phase IVb, Parallel Study Group to Compare the Efficacy and Safety of 5 mg and 10 mg Rosuvastatin Unknown status NCT01613729 Phase 4 Rosuvastatin 5 mg;Rosuvastatin 10 mg
11 An Randomized Open Label Trial on the Impact of 24 Weeks of Atorvastatin Therapy on Liver Fat Content and Abdominal Fat Content in Patients With Type 2 Diabetes Combined With High LDL-C and Non-alcoholic Fatty Liver Disease Unknown status NCT01720719 Phase 4 atorvastatin;Vitamin E
12 Ezetimibe Reverse Cholesterol Transport (RCT) Pilot Study Completed NCT00701727 Phase 4 ezetimibe;Placebo
13 A Multi-center, Open-label, Randomized, Active-control, Parallel-group Designed Study to Compare Effects of Nateglinide and Acarbose on Postprandial Status in Chinese Drug-naive Type 2 Diabetes Mellitus Patients Completed NCT00928889 Phase 4 Nateglinide 120 mg;Acarbose 50 mg
14 A 12-Week, Double-Blind, Randomized, Placebo-Controlled Study to Assess the LDL Cholesterol Lowering and Anti-Hyperglycemic Efficacy of Welchol® (Colesevelam) in Subjects With Impaired Fasting Glucose Who Are Taking Niaspan® (Niacin) for Dyslipidemia Completed NCT01239004 Phase 4 Placebo;Colesevelam
15 SLIM: Combined Effects of Slo-Niacin and Atorvastatin on Lipoproteins and Inflammatory Markers Completed NCT00194402 Phase 4 Slo-Niacin, atorvastatin
16 Efficacy and Safety of Fluvastatin 80 mg or Valsartan 160 mg and Their Combination in Dyslipidemic Patients With Arterial Hypertension and Endothelial Dysfunction Completed NCT00171327 Phase 4 valsartan, fluvastatin
17 Efficacy of a Computerised Physician Reminder System to Control Cardiovascular Risk Factors in HIV-infected Patients Receiving Antiretroviral Therapy: A Nested Randomised Controlled Cluster Trial Within the Swiss HIV Cohort Study Completed NCT00264394 Phase 4
18 Yoga for the Management of HIV-Metabolic Syndromes Completed NCT00627380 Phase 4
19 Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Subjects With Type IIa and IIb Hypercholesterolaemia Completed NCT00631189 Phase 4 Rosuvastatin;Pravastatin;Atorvastatin
20 Neointimal Coverage After Implantation of Biolimus Eluting Stent With Biodegradable Polymer: Optical Coherence Tomographic Assessment According to the Treatment of Dyslipidemia and Hypertension and the Types of Implanted Drug-eluting Stents Completed NCT01502904 Phase 4 pravastatin 20mg/day after DES implantation;pitavastatin 2mg/day after DES implantation;Non-ARB /day after DES implantation;Eposartan 600mg/day after DES implantation
21 A 12-week, Multicenter, Double-blind, Double-dummy, Randomized, Active-controlled, Parallel-group Study to Assess the Efficacy and Safety of Fluvastatin Sodium Extended Release Tablets 80 mg Once Daily Compared to Fluvastatin Sodium Immediate Release Capsules 40 mg Twice Daily (BID) in Chinese Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia at Moderate or High Cardiovascular Risk Who Did Not Achieve Their Lipid Goals When Treated With Fluvastatin Sodium Immediate Release Capsules 40 mg QD Completed NCT01551173 Phase 4 Fluvastatin sodium
22 Open Label Study Evaluating The Use Of Combination Therapy Of Ezetimibe And Statins In Patients With Dyslipidemia In Colombia Completed NCT00651963 Phase 4 ezetimibe
23 Serial EValuation of multiplE Coronary Artery Diseases by an Optical Coherence Tomography; Assessment of the Changes of de Novo Lesions and Comparisons of Neointimal Coverage Between Xience Prime® Versus Cypher SelectTM Stents; SEVEN-Xience Study Completed NCT01856374 Phase 4 Pravastatin 20mg;Atorvastatin 40mg
24 The Effect of Fibrate Therapy in Two Patients With Neutral Lipid Storage Disease With Myopathy (NLSDM) Completed NCT01527318 Phase 4 Fibrate treatment
25 Assessment of the Efficacy and Tolerability of Two Formulations of Atorvastatin In Korean Adult With Hypercholesterolemia : A Multicenter, Prospective, Open-Label, Randomized, Trial Completed NCT01285544 Phase 4 Atorvastatin (Lipinon);Atorvastatin (Lipitor)
26 A Multi-center, Randomized, Double-blinded Equivalence Clinical Trial to Evaluate Efficacy and Safety of LipiLou 20 mg Versus Lipitor 20 mg in Hypercholesterolemic Patients With Higher Risk Cardiovascular Disease in Korea Completed NCT01029522 Phase 4 Atorvastatin (Lipilou);Atorvastatin (Lipitor)
27 Fat Reduction in the Submental Area - a Sequential Treatment Approach With CoolMini and KYBELLA® Completed NCT03510598 Phase 4 Kybella 20 MG in 2 ML Injection
28 Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate With the Metabolic Syndrome Completed NCT00632840 Phase 4 Atorvastatin and fenofibrate
29 Effect of Anthocyanins on Metabolic Profiles in Subjects With Pre-diabetes: A Randomized, Double-blind, Placebo-controlled Study Completed NCT02689765 Phase 4
30 Effect of PPAR-Delta Agonist on Lipoprotein Kinetics in Metabolic Syndrome Completed NCT00841217 Phase 4 GW501516;placebo pill
31 Acute Effects of Sodium-glucose Cotransporter-2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes Completed NCT04193566 Phase 4 Forxiga
32 Open-label, Randomized, Single Center, Paralleled Clinical Study to Evaluate Adherence Improvement Fixed-dose Combination of Olostar Tab. in Patients With Hypertension and Dyslipidemia Completed NCT04061824 Phase 4 Olostar Tab (olmesartan/rosuvastatin FDC(fixed dose combination));Two separated drugs(ARB(Angiotensin â…¡ receptor blocker) and statin)
33 An Open-label, Multi-center Study to Evaluate the Efficacy and Safety of Statin-fenofibrate Combination Therapy in Dyslipidemic Chinese Patients Completed NCT01462877 Phase 4 fenofibrate
34 Statins and Noncardiovascular Endpoints Completed NCT00330980 Phase 4 40 mg Pravastatin (Pravachol);20 mg Simvastatin;Placebo
35 A Multicenter, Eight-Week Treatment, Single Step Titration, Open-Label Study Assessing The Percentage Of Subjects Achieving Low Density Lipoprotein Cholesterol Target With Atorvastatin Starting Doses Of 10 Mg, 20 Mg, 40 Mg, And 80 Mg (Latin American Atorvastatin ATGOAL Study) Completed NCT00645151 Phase 4 Atorvastatin;Atorvastatin;Atorvastatin
36 Effect On Serum Cholesterol Of Dairy Products With Addition Of Esterified Phytosterols In Chilean Subjects With Hypercholesterolemia Completed NCT02644109 Phase 4
37 A Multicenter, Eight-Week Treatment, Single-Step Titration, Open-Label Study Assessing The Percentage Of Dyslipidemic Patients Achieving LDL Cholesterol Target With Atorvastatin Starting Doses Of 10 Mg, 20 Mg, And 40 Mg Completed NCT00647543 Phase 4 Atorvastatin;Atorvastatin;Atorvastatin
38 A Multicenter, Open-Label Extension Study Of High-Risk Hyperlipidemic Patients Treated With An Atorvastatin Starting Dose Adapted To Their Baseline LDL-C Level Completed NCT00644709 Phase 4 Atorvastatin
39 A Multicenter, Twelve-Week Treatment, Single-Step Titration, Open-Label Study Assessing The Percentage Of Dyslipidemic High-Risk Patients Achieving LDL Cholesterol Targets With Atorvastatin Starting Doses Of 10 Mg, 20 Mg And 40 Mg. Completed NCT00644670 Phase 4 Atorvastatin;Atorvastatin
40 Comparison Between XueZhiKang and Simvastatin on Fatigue: a Single-center, Randomized Clinical Trial Completed NCT01686451 Phase 4 XueZhiKang;simvastatin
41 A Multicenter, Eight-Week Treatment, Single-Step Titration Open-Label Study Assessing The Percentage Of Korean Dyslipidemic Patients Achieving LDL Cholesterol Target With Atorvastatin Starting Doses Of 10 MG, 20 MG, And 40 MG. Completed NCT00540293 Phase 4 Atorvastatin
42 Efficacy and Safety of Extended Release Niacin-Fenofibrate Combination and Monotherapy for the Treatment of Atherogenic Dyslipidemia in Obese Females Completed NCT03615534 Phase 4 Fenofibrate
43 Metformin for Treatment of Antipsychotic-induced Dyslipidemia: a Randomized, Double-blind Study Completed NCT01778244 Phase 4 metformin
44 Efficacy of Atorvastatin Versus Rosuvastatin on LV Function and Inflammatory Biomarkers in Type 2 Diabetic Patients With Dyslipidemia Completed NCT03784703 Phase 4 Atorvastatin 40 Mg Oral Tablet;Rosuvastatin 10 Mg Oral Tablet
45 A RANDOMIZED, DOUBLE-BLIND, ACTIVE CONTROLLED, PARALLEL GROUP STUDY OF PITAVASTATIN 4 MG VS. PRAVASTATIN 40 MG IN PATIENTS WITH PRIMARY HYPERLIPIDEMIA OR MIXED DYSLIPIDEMIA Completed NCT01256476 Phase 4 pitavastatin;pravastatin
46 A 12-Week, Randomized, Double-Blind, Active-Controlled, Parallel-Group Study Comparing Pitavastatin 4 mg vs. Pravastatin 40 mg in HIV-Infected Subjects With Dyslipidemia, Followed by a 40-Week Safety Extension Study Completed NCT01301066 Phase 4 Pitavastatin;Pravastatin
47 A Randomized, Open-Label, Parallel Group Study to Evaluate the Efficacy and Safety of Alirocumab Versus Usual Care in Patients With Type 2 Diabetes and Mixed Dyslipidemia at High Cardiovascular Risk With Non-HDL-C Not Adequately Controlled With Maximally Tolerated Statin Therapy Completed NCT02642159 Phase 4 Alirocumab;Statins;Ezetimibe;Fenofibrate;Nicotinic acid;Omega-3 fatty acids;Antihyperglycemic Drug
48 A Multicenter, Pragmatic Randomized, Double-blind, Placebo-controlled Trial of Xuezhikang Capsule for Treating Dyslipidemia: a Postmarketing Study Completed NCT02057302 Phase 4 Xuezhikang capsule
49 A Randomized, Double-blind, Placebo-controlled, Parallel-group, Study Evaluating the Efficacy, Safety, and Duration of Erection of Flexible-dose Vardenafil Administered for 12 Weeks Compared to Placebo in Subjects With Erectile Dysfunction and Dyslipidemia Completed NCT00379756 Phase 4 LEVITRA (vardenafil);placebo
50 Prospective, Randomised, Crossover, Double-Blind, Placebo-Controlled Trial To Assess The Lipid-Lowering Effect Of Adding Tenofovir/Emtricitabine Co-Formulation Vs Placebo To Hiv-1-Infected Subjects With Dyslipidemia And Sustained Viral Load Suppression Under Monotherapy With Ritonavir-Boosted Protease Inhibitors Completed NCT01458977 Phase 4 Truvada® (300 mg tenofovir disoproxil fumarato/200 mg emtricitabine);Placebo

Search NIH Clinical Center for Lipid Metabolism Disorder

Cochrane evidence based reviews: lipid metabolism, inborn errors

Sources

Genetic Tests for Lipid Metabolism Disorder

About this section

Genetic tests related to Lipid Metabolism Disorder:

# Genetic test Affiliating Genes
1 Disorder of Fatty Acid Metabolism 29
2 Abnormality of Lipid Metabolism 29
Sources

Anatomical Context for Lipid Metabolism Disorder

About this section

MalaCards organs/tissues related to Lipid Metabolism Disorder:

40
Liver, Heart, Kidney, Endothelial, Ovary, Thyroid, Bone
Sources

Publications for Lipid Metabolism Disorder

About this section

Articles related to Lipid Metabolism Disorder:

(show top 50) (show all 29011)
# Title Authors PMID Year
1
NGS-based expanded carrier screening for genetic disorders in North Indian population reveals unexpected results - a pilot study. 42
33138774 2020
2
Not So Slim Anymore-Evidence for the Role of SUMO in the Regulation of Lipid Metabolism. 42
32781719 2020
3
Lipophagy and Lipolysis Status in Lipid Storage and Lipid Metabolism Diseases. 42
32854299 2020
4
Targeting dyslipidemia in the metabolic syndrome: an update. 54 61
19485929 2010
5
Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity. 61 54
20388526 2010
6
Ala54Thr polymorphism of fatty acid-binding protein 2 gene and fasting blood lipids: a meta-analysis. 54 61
20047744 2010
7
A novel germline mutation in peroxisome proliferator-activated receptor gamma gene associated with large intestine polyp formation and dyslipidemia. 54 61
20123124 2010
8
Insulin resistance is associated with C-reactive protein independent of abdominal obesity in nondiabetic Taiwanese. 54 61
20004425 2010
9
Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome. 61 54
20199774 2010
10
Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese men. 54 61
20339372 2010
11
Osteoprotegerin in relation to type 2 diabetes mellitus and the metabolic syndrome in postmenopausal women. 54 61
19922962 2010
12
Fenofibrate antagonizes Chk2 activation by inducing Wip1 expression: implications for cell proliferation and tumorigenesis. 54 61
20226795 2010
13
Is there a link between inflammation and abnormal lipoprotein profile in Sjögren's syndrome? 61 54
20378384 2010
14
The effect of PPAR-alpha agonism on apolipoprotein metabolism in humans. 61 54
20005515 2010
15
Type 2 diabetes mellitus is characterized by reduced postprandial adiponectin response: a possible link with diabetic postprandial dyslipidemia. 61 54
19922965 2010
16
Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study. 54 61
20200337 2010
17
[Statins in the management of acute coronary syndrome]. 61 54
20387563 2010
18
Liver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster model. 61 54
19965597 2010
19
Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population. 61 54
20186155 2010
20
Cardiovascular and metabolic risk profile and acylation-stimulating protein levels in children with Prader-Willi syndrome and effects of growth hormone treatment. 54 61
20173020 2010
21
Hormone and pharmaceutical regulation of ASP production in 3T3-L1 adipocytes. 54 61
20069551 2010
22
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Variations for Lipid Metabolism Disorder

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ClinVar genetic disease variations for Lipid Metabolism Disorder:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 APOE NM_000041.4(APOE):c.461G>T (p.Arg154Leu) SNV Likely pathogenic 375636 rs200703101 GRCh37: 19:45412014-45412014
GRCh38: 19:44908757-44908757
Sources

Expression for Lipid Metabolism Disorder

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Search GEO for disease gene expression data for Lipid Metabolism Disorder.
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Pathways for Lipid Metabolism Disorder

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Pathways related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Metabolism 65
Show member pathways
 14 PPARG PPARA MTTP LPL LIPC INS
2
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 65
Show member pathways
 12.75 PPARG PPARA LPL LEP HMGCR FADS1
3
Metabolism of water-soluble vitamins and cofactors 65
Show member pathways
 12.57 LPL APOE APOC3 APOB APOA1
4
Lipoprotein metabolism 65
Show member pathways
 12.45 MTTP LPL LIPC CETP APOE APOC3
5
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.4 PPARG LEP INS HMGCR ADIPOQ
6
Folate Metabolism 1
Show member pathways
 12.27 SERPINE1 INS CRP APOE APOB APOA1
7
Metabolism of fat-soluble vitamins 65
Show member pathways
 12.24 LPL APOE APOC3 APOB APOA1
9
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.81 PPARG LPL LEP INS ADIPOQ
10
Adipogenesis 1
11.68 SERPINE1 RETN PPARG PPARA LPL LEP
11
Sterol Regulatory Element-Binding Proteins (SREBP) signalling 1
11.66 PPARG LPL INS HMGCR
12
Adipocytokine signaling pathway 36
11.59 PPARA LEP ADIPOQ
13
PPAR signaling pathway 36
11.58 PPARG PPARA LPL APOC3 APOA5 APOA1
14
Fat digestion and absorption 36
Show member pathways
 11.4 MTTP APOB APOA1
15
Statin Pathway 1
Show member pathways
 11.39 MTTP LPL LIPC HMGCR CETP APOE
16
Differentiation of white and brown adipocyte 1
11.11 PPARG LEP ADIPOQ
17
PPAR Alpha Pathway 1
11.08 PPARA APOC3 APOA5 APOA1
18
Transcription factor regulation in adipogenesis 1
11.04 PPARG LEP ADIPOQ
Sources

GO Terms for Lipid Metabolism Disorder

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Cellular components related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.2 SERPINE1 RETN LPL LIPC LEP INS
2 extracellular space GO:0005615 10.13 SERPINE1 RETN LPL LIPC LEP INS
3 endoplasmic reticulum lumen GO:0005788 9.98 MTTP LIPC INS APOE APOB APOA5
4 collagen-containing extracellular matrix GO:0062023 9.91 SERPINE1 APOE APOC3 APOA1 ADIPOQ
5 early endosome GO:0005769 9.88 APOE APOC3 APOB APOA5 APOA1
6 low-density lipoprotein particle GO:0034362 9.71 APOE APOB APOA5 APOA1
7 intermediate-density lipoprotein particle GO:0034363 9.67 APOE APOC3 APOB APOA1
8 endocytic vesicle lumen GO:0071682 9.63 APOE APOB APOA1
9 high-density lipoprotein particle GO:0034364 9.63 LIPC CETP APOE APOB APOA5 APOA1
10 spherical high-density lipoprotein particle GO:0034366 9.52 APOC3 APOA1
11 discoidal high-density lipoprotein particle GO:0034365 9.49 APOE APOA1
12 very-low-density lipoprotein particle GO:0034361 9.43 LPL APOE APOC3 APOB APOA5 APOA1
13 chylomicron GO:0042627 9.1 LPL APOE APOC3 APOB APOA5 APOA1

Biological processes related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 10.1 PPARG MTTP LPL LIPC LEP HMGCR
2 lipid transport GO:0006869 10.09 MTTP CETP APOE APOC3 APOB APOA5
3 cellular protein metabolic process GO:0044267 10.08 INS APOE APOB APOA5 APOA1
4 regulation of lipid metabolic process GO:0019216 10.07 PPARG PPARA HMGCR FADS1 APOA5 APOA1
5 response to nutrient GO:0007584 10.06 PPARG LEP HMGCR FADS1 APOA1 ADIPOQ
6 negative regulation of inflammatory response GO:0050728 10.05 PPARG PPARA APOE APOA1 ADIPOQ
7 steroid metabolic process GO:0008202 10.04 HMGCR CETP APOE APOB APOA1
8 fatty acid metabolic process GO:0006631 10.02 PPARG PPARA LPL FADS1
9 cholesterol metabolic process GO:0008203 10.02 LIPC LEP HMGCR CETP APOE APOB
10 retinoid metabolic process GO:0001523 10.01 LPL APOE APOC3 APOB APOA1
11 intermembrane lipid transfer GO:0120009 10 MTTP CETP APOE APOB APOA1
12 lipid catabolic process GO:0016042 9.99 LPL LIPC APOC3 APOB
13 response to ethanol GO:0045471 9.99 PPARA LEP HMGCR ADIPOQ
14 glucose homeostasis GO:0042593 9.99 PPARG LEP INS ADIPOQ
15 circadian rhythm GO:0007623 9.97 SERPINE1 MTTP LEP ADIPOQ
16 response to insulin GO:0032868 9.97 RETN PPARA LEP FADS1
17 triglyceride catabolic process GO:0019433 9.97 LPL LIPC APOC3 APOB APOA5
18 cholesterol efflux GO:0033344 9.96 APOE APOC3 APOB APOA5 APOA1
19 response to organic substance GO:0010033 9.93 PPARG FADS1 APOB
20 positive regulation of lipid biosynthetic process GO:0046889 9.93 PPARA INS APOE APOA5 APOA1
21 response to nutrient levels GO:0031667 9.92 LEP HMGCR ADIPOQ
22 fatty acid biosynthetic process GO:0006633 9.92 LPL LIPC FADS1
23 cholesterol transport GO:0030301 9.92 LIPC CETP APOB APOA1
24 reverse cholesterol transport GO:0043691 9.92 LIPC CETP APOE APOC3 APOA1
25 regulation of blood pressure GO:0008217 9.91 PPARG LEP ACE
26 high-density lipoprotein particle remodeling GO:0034375 9.91 LIPC CETP APOE APOC3 APOA1
27 triglyceride metabolic process GO:0006641 9.91 MTTP LPL CETP APOE APOC3 APOA5
28 glucose metabolic process GO:0006006 9.9 LEP INS ADIPOQ
29 phospholipid efflux GO:0033700 9.9 APOE APOC3 APOA5 APOA1
30 lipid homeostasis GO:0055088 9.89 PPARG CETP APOE
31 low-density lipoprotein particle remodeling GO:0034374 9.89 MTTP LIPC CETP APOE APOB
32 phospholipid transport GO:0015914 9.88 MTTP CETP APOA1
33 negative regulation of MAP kinase activity GO:0043407 9.88 HMGCR APOE ADIPOQ
34 chylomicron remnant clearance GO:0034382 9.88 LIPC APOE APOC3 APOB
35 cholesterol biosynthetic process GO:0006695 9.87 HMGCR APOA5 APOA1
36 negative regulation of protein secretion GO:0050709 9.86 INS HMGCR APOE
37 positive regulation of cholesterol efflux GO:0010875 9.85 APOE APOA1 ADIPOQ
38 phosphatidylcholine metabolic process GO:0046470 9.85 CETP APOA5 APOA1
39 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.85 PPARG PPARA CRP CETP ADIPOQ
40 lipoprotein transport GO:0042953 9.84 PPARG MTTP APOB
41 high-density lipoprotein particle assembly GO:0034380 9.83 APOE APOA5 APOA1
42 very-low-density lipoprotein particle assembly GO:0034379 9.83 MTTP APOC3 APOB
43 positive regulation of cholesterol esterification GO:0010873 9.82 APOE APOA5 APOA1
44 regulation of Cdc42 protein signal transduction GO:0032489 9.81 APOE APOC3 APOA1
45 positive regulation of fatty acid metabolic process GO:0045923 9.81 PPARG PPARA ADIPOQ
46 lipoprotein biosynthetic process GO:0042158 9.8 APOE APOB APOA1
47 regulation of intestinal cholesterol absorption GO:0030300 9.8 LEP APOA5 APOA1
48 chylomicron assembly GO:0034378 9.8 MTTP APOE APOC3 APOB APOA1
49 chylomicron remodeling GO:0034371 9.77 LPL APOE APOC3 APOB APOA1
50 positive regulation of fatty acid biosynthetic process GO:0045723 9.75 APOA5 APOA1

Molecular functions related to Lipid Metabolism Disorder according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.97 SERPINE1 LPL LEP APOE APOA1 ADIPOQ
2 heparin binding GO:0008201 9.85 LPL LIPC APOE APOB APOA5
3 hormone activity GO:0005179 9.81 RETN LEP INS ADIPOQ
4 phospholipid binding GO:0005543 9.77 APOE APOC3 APOB APOA5 APOA1
5 cholesterol binding GO:0015485 9.73 CETP APOC3 APOA5 APOA1
6 phosphatidylcholine binding GO:0031210 9.7 CETP APOA5 APOA1
7 lipid binding GO:0008289 9.7 PPARA MTTP CETP APOE APOC3 APOA5
8 apolipoprotein binding GO:0034185 9.65 MTTP LPL LIPC
9 phospholipase A1 activity GO:0008970 9.6 LPL LIPC
10 phosphatidylserine 1-acylhydrolase activity GO:0052739 9.59 LPL LIPC
11 1-acyl-2-lysophosphatidylserine acylhydrolase activity GO:0052740 9.58 LPL LIPC
12 lipase inhibitor activity GO:0055102 9.58 APOC3 APOA1
13 lipoprotein particle binding GO:0071813 9.58 LPL APOE APOA1
14 lipase binding GO:0035473 9.57 APOB APOA5
15 lipoprotein lipase activity GO:0004465 9.56 LPL LIPC
16 lipid transporter activity GO:0005319 9.56 MTTP APOE APOB APOA1
17 triglyceride binding GO:0017129 9.55 LPL CETP
18 high-density lipoprotein particle receptor binding GO:0070653 9.54 APOC3 APOA1
19 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.5 APOE APOA5 APOA1
20 low-density lipoprotein particle receptor binding GO:0050750 9.26 CRP APOE APOB APOA5
21 intermembrane cholesterol transfer activity GO:0120020 9.02 MTTP CETP APOE APOB APOA1
Sources

Sources for Lipid Metabolism Disorder

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy