Lipid-Rich Breast Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lipid-Rich Breast Carcinoma

MalaCards integrated aliases for Lipid-Rich Breast Carcinoma:

Name: Lipid-Rich Breast Carcinoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7076

NCIt ⁵⁰ C40365

UMLS ⁷¹ C1517894

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Summaries for Lipid-Rich Breast Carcinoma

Disease Ontology : ¹² A lipid-rich carcinoma characterized by the presence of cytoplasmic neutral lipids in the vast majority of the malignant cells.

MalaCards based summary : Lipid-Rich Breast Carcinoma is related to glassy cell carcinoma of the cervix and breast intraductal papillomatosis, and has symptoms including pain An important gene associated with Lipid-Rich Breast Carcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Prolactin Signaling Pathway. Affiliated tissues include breast, and related phenotypes are integument and limbs/digits/tail

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Related Diseases for Lipid-Rich Breast Carcinoma

Diseases related to Lipid-Rich Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)

#	Related Disease	Score	Top Affiliating Genes
1	glassy cell carcinoma of the cervix	10.2	PGR ERBB2
2	breast intraductal papillomatosis	10.2	PGR ERBB2
3	nipple carcinoma	10.2	PGR ERBB2
4	scirrhous adenocarcinoma	10.2	PGR ERBB2
5	oncocytic breast carcinoma	10.1	PGR ERBB2
6	apocrine adenosis of breast	10.1	PGR ERBB2
7	luminal breast carcinoma b	10.1	PGR ERBB2
8	comedo carcinoma	10.1	PGR ERBB2
9	breast adenoid cystic carcinoma	10.1	PGR ERBB2
10	gastric diffuse adenocarcinoma	10.1	PGR ERBB2
11	linitis plastica	10.1	PGR ERBB2
12	triple-receptor negative breast cancer	10.1	PGR ERBB2
13	progesterone-receptor negative breast cancer	10.1	PGR ERBB2
14	breast neuroendocrine neoplasm	10.1	PGR ERBB2
15	breast papillomatosis	10.1	PGR ERBB2
16	primary peritoneal carcinoma	10.1	PGR ERBB2
17	galactorrhea	10.1	PRLR PRL
18	granulosa cell tumor of the ovary	10.1	PRL ERBB2
19	progesterone-receptor positive breast cancer	10.1	PGR ERBB2
20	microglandular adenosis	10.1	PGR ERBB2
21	chromophobe adenoma	10.1	PRLR PRL
22	vulvar disease	10.1	PGR ERBB2
23	endometrial serous adenocarcinoma	10.1	PGR ERBB2
24	hypertrophy of breast	10.1	PGR ERBB2
25	retinitis pigmentosa 47	10.1	PGR ERBB2
26	female reproductive endometrioid cancer	10.1	PGR ERBB2
27	inflammatory breast carcinoma	10.1	PGR ERBB2
28	adenosarcoma	10.1	PGR ERBB2
29	mulchandani-bhoj-conlin syndrome	10.1	PGR ERBB2
30	breast cystic hypersecretory carcinoma	10.1	KRT5 ERBB2
31	vulva basal cell carcinoma	10.1	KRT5 ERBB2
32	cerebral meningioma	10.1	PRLR PGR
33	breast squamous cell carcinoma	10.1	KRT5 ERBB2
34	endocervical carcinoma	10.1	PGR ERBB2
35	esophageal adenosquamous carcinoma	10.1	KRT5 ERBB2
36	pyometritis	10.1	PRL PGR
37	short syndrome	10.1	PGR ERBB2
38	uterine corpus cancer	10.1	PGR ERBB2
39	breast fibroadenoma	10.1	PGR ERBB2
40	bilateral breast cancer	10.1	PGR ERBB2
41	estrogen excess	10.1	PRL PGR
42	teeth hard tissue disease	10.0	PGR ERBB2
43	sebaceous adenocarcinoma	10.0	KRT5 ERBB2
44	fallopian tube carcinoma	10.0	PGR ERBB2
45	rapidly involuting congenital hemangioma	10.0
46	basaloid lung carcinoma	10.0	PGR KRT5
47	pregnancy adenoma	10.0	PGR KRT5
48	estrogen-receptor negative breast cancer	10.0	PGR ERBB2
49	external ear carcinoma	10.0	PGR KRT5
50	breast myoepithelial carcinoma	10.0	PGR KRT5

Graphical network of the top 20 diseases related to Lipid-Rich Breast Carcinoma:

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Symptoms & Phenotypes for Lipid-Rich Breast Carcinoma

UMLS symptoms related to Lipid-Rich Breast Carcinoma:

pain

MGI Mouse Phenotypes related to Lipid-Rich Breast Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.55	ERBB2 KRT5 PGR PRL PRLR
2	limbs/digits/tail	MP:0005371	9.26	ERBB2 KRT5 PGR PRLR
3	neoplasm	MP:0002006	8.92	ERBB2 PGR PRL PRLR

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Drugs & Therapeutics for Lipid-Rich Breast Carcinoma

Search Clinical Trials , NIH Clinical Center for Lipid-Rich Breast Carcinoma

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Genetic Tests for Lipid-Rich Breast Carcinoma

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Anatomical Context for Lipid-Rich Breast Carcinoma

MalaCards organs/tissues related to Lipid-Rich Breast Carcinoma:

⁴⁰

Breast

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Publications for Lipid-Rich Breast Carcinoma

Articles related to Lipid-Rich Breast Carcinoma:

#	Title	Authors	PMID	Year
1	Clear cell carcinoma of breast lipid-rich variant. ⁶¹	Kini H...Thomas M	31603128	2019
2	Lipid-rich carcinoma of the breast: a case report. ⁶¹	Shi P...Sun JZ	18411586	2008
3	Pathologic quiz case: a 62-year-old woman with a 4.5-cm nodule in the right breast. Lipid-rich breast carcinoma. ⁶¹	Reis-Filho JS...Schmitt FC	12951994	2003

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Genes for Lipid-Rich Breast Carcinoma

Genes related to Lipid-Rich Breast Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	4.97	DISEASES inferred ¹⁵
2	PRLR	Prolactin Receptor	Protein Coding	4.79	DISEASES inferred ¹⁵
3	PGR	Progesterone Receptor	Protein Coding	3.95	DISEASES inferred ¹⁵
4	KRT5	Keratin 5	Protein Coding	3.81	DISEASES inferred ¹⁵
5	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	3.51	DISEASES inferred ¹⁵
6	PRL	Prolactin	Protein Coding	3.46	DISEASES inferred ¹⁵

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Variations for Lipid-Rich Breast Carcinoma

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Expression for Lipid-Rich Breast Carcinoma

Search GEO for disease gene expression data for Lipid-Rich Breast Carcinoma.

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Pathways for Lipid-Rich Breast Carcinoma

Pathways related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	12.78	PRLR PRL MUC1 ERBB2
2	Prolactin Signaling Pathway ¹ ³⁶ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	11.78	PRLR PRL ERBB2
3	Glucocorticoid receptor regulatory network ¹	11.32	PRL KRT5
4	Signaling events mediated by PTP1B ¹	11.02	PRLR PRL
5	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	10.96	PRLR PRL PGR ERBB2
6	Growth hormone receptor signaling ⁶⁵ Show member pathways Prolactin receptor signaling ⁶⁵	10.87	PRLR PRL
7	Ovarian Infertility Genes ¹	10.46	PRLR PGR

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GO Terms for Lipid-Rich Breast Carcinoma

Cellular components related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endosome lumen	GO:0031904	8.62	PRLR PRL

Biological processes related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation	GO:0008284	9.43	PRLR PRL ERBB2
2	lactation	GO:0007595	9.16	PRLR PRL
3	mammary gland development	GO:0030879	8.96	PRL PGR
4	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	8.62	PRLR PRL

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Sources for Lipid-Rich Breast Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia