Lipid-Rich Breast Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lipid-Rich Breast Carcinoma

MalaCards integrated aliases for Lipid-Rich Breast Carcinoma:

Name: Lipid-Rich Breast Carcinoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7076

NCIt ⁴⁹ C40365

UMLS ⁷¹ C1517894

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Summaries for Lipid-Rich Breast Carcinoma

Disease Ontology : ¹² A lipid-rich carcinoma characterized by the presence of cytoplasmic neutral lipids in the vast majority of the malignant cells.

MalaCards based summary : Lipid-Rich Breast Carcinoma is related to breast cancer and glassy cell carcinoma of the cervix, and has symptoms including pain An important gene associated with Lipid-Rich Breast Carcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Prolactin Signaling Pathway and Signaling events mediated by PTP1B. Affiliated tissues include breast.

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Related Diseases for Lipid-Rich Breast Carcinoma

Diseases related to Lipid-Rich Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)

#	Related Disease	Score	Top Affiliating Genes
1	breast cancer	27.6	PRLR PRL PGR MUC1 KRT5 ERBB2
2	glassy cell carcinoma of the cervix	10.3	PGR ERBB2
3	scirrhous adenocarcinoma	10.3	PGR ERBB2
4	oncocytic breast carcinoma	10.3	PGR ERBB2
5	apocrine adenosis of breast	10.3	PGR ERBB2
6	comedo carcinoma	10.3	PGR ERBB2
7	breast adenoid cystic carcinoma	10.3	PGR ERBB2
8	glycogen-rich clear cell breast carcinoma	10.3	PRLR PGR
9	triple-receptor negative breast cancer	10.3	PGR ERBB2
10	breast squamous cell carcinoma	10.3	KRT5 ERBB2
11	progesterone-receptor negative breast cancer	10.3	PGR ERBB2
12	primary peritoneal carcinoma	10.3	PGR ERBB2
13	microglandular adenosis	10.3	PGR ERBB2
14	progesterone-receptor positive breast cancer	10.3	PGR ERBB2
15	endometrial serous adenocarcinoma	10.2	PGR ERBB2
16	sebaceous breast carcinoma	10.2	ERBB2 CEACAM5
17	eccrine mixed tumor of skin	10.2	ERBB2 CEACAM5
18	hypertrophy of breast	10.2	PGR ERBB2
19	parotid gland adenoid cystic carcinoma	10.2	ERBB2 CEACAM5
20	cerebral meningioma	10.2	PRLR PGR
21	female reproductive endometrioid cancer	10.2	PGR ERBB2
22	laryngeal mucoepidermoid carcinoma	10.2	ERBB2 CEACAM5
23	inflammatory breast carcinoma	10.2	PGR ERBB2
24	pregnancy adenoma	10.2	PGR KRT5
25	vulval paget's disease	10.2	ERBB2 CEACAM5
26	basaloid lung carcinoma	10.2	PGR KRT5
27	adenosarcoma	10.2	PGR ERBB2
28	mulchandani-bhoj-conlin syndrome	10.2	PGR ERBB2
29	breast myoepithelial carcinoma	10.2	PGR KRT5
30	chronic tympanitis	10.2	PGR MUC1
31	fallopian tube endometriosis	10.2	PGR CEACAM5
32	parotid disease	10.2	MUC1 ERBB2
33	mixed fibrolamellar hepatocellular carcinoma	10.2	MUC1 ERBB2
34	urethral villous adenoma	10.2	PGR CEACAM5
35	granulomatous endometritis	10.2	PGR CEACAM5
36	vaginal glandular tumor	10.2	PGR CEACAM5
37	cervical serous adenocarcinoma	10.2	PGR CEACAM5
38	uterus leiomyosarcoma	10.2	PGR KRT5
39	vulvar syringoma	10.2	PGR CEACAM5
40	endometrial mucinous adenocarcinoma	10.2	PGR MUC1
41	liver leiomyoma	10.2	PGR CEACAM5
42	sebaceous adenocarcinoma	10.2	KRT5 ERBB2
43	intracystic papillary adenoma	10.2	PRL ERBB2
44	ureter adenocarcinoma	10.2	KRT5 CEACAM5
45	mucoepidermoid esophageal carcinoma	10.2	KRT5 CEACAM5
46	papillary adenoma	10.2	KRT5 CEACAM5
47	transitional meningioma	10.2	PGR MUC1
48	malignant acrospiroma	10.2	KRT5 CEACAM5
49	endosalpingiosis	10.2	PGR MUC1
50	gallbladder squamous cell carcinoma	10.2	KRT5 CEACAM5

Graphical network of the top 20 diseases related to Lipid-Rich Breast Carcinoma:

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Symptoms & Phenotypes for Lipid-Rich Breast Carcinoma

UMLS symptoms related to Lipid-Rich Breast Carcinoma:

pain

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Drugs & Therapeutics for Lipid-Rich Breast Carcinoma

Search Clinical Trials , NIH Clinical Center for Lipid-Rich Breast Carcinoma

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Genetic Tests for Lipid-Rich Breast Carcinoma

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Anatomical Context for Lipid-Rich Breast Carcinoma

MalaCards organs/tissues related to Lipid-Rich Breast Carcinoma:

⁴⁰

Breast

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Publications for Lipid-Rich Breast Carcinoma

Articles related to Lipid-Rich Breast Carcinoma:

#	Title	Authors	PMID	Year
1	Clear cell carcinoma of breast lipid-rich variant. ⁶¹	Kini H...Thomas M	31603128	2019
2	Lipid-rich carcinoma of the breast: a case report. ⁶¹	Shi P...Sun JZ	18411586	2008
3	Pathologic quiz case: a 62-year-old woman with a 4.5-cm nodule in the right breast. Lipid-rich breast carcinoma. ⁶¹	Reis-Filho JS...Schmitt FC	12951994	2003

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Genes for Lipid-Rich Breast Carcinoma

Genes related to Lipid-Rich Breast Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	5.04	DISEASES inferred ¹⁵
2	PRLR	Prolactin Receptor	Protein Coding	4.79	DISEASES inferred ¹⁵
3	PGR	Progesterone Receptor	Protein Coding	4.02	DISEASES inferred ¹⁵
4	KRT5	Keratin 5	Protein Coding	3.87	DISEASES inferred ¹⁵
5	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	3.56	DISEASES inferred ¹⁵
6	PRL	Prolactin	Protein Coding	3.5	DISEASES inferred ¹⁵
7	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	3.48	DISEASES inferred ¹⁵
8	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	3.23	DISEASES inferred ¹⁵

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Variations for Lipid-Rich Breast Carcinoma

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Expression for Lipid-Rich Breast Carcinoma

Search GEO for disease gene expression data for Lipid-Rich Breast Carcinoma.

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Pathways for Lipid-Rich Breast Carcinoma

Pathways related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	11.88	PRLR PRL ERBB2
2	Signaling events mediated by PTP1B ¹	11.07	PRLR PRL
3	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	10.96	PRLR PRL PGR ERBB2
4	Growth hormone receptor signaling ⁶⁵ Show member pathways Prolactin receptor signaling ⁶⁵	10.93	PRLR PRL
5	Cell adhesion_Cell-matrix glycoconjugates ²²	10.75	MUC1 CEACAM5
6	Ovarian Infertility Genes ¹	10.46	PRLR PGR

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GO Terms for Lipid-Rich Breast Carcinoma

Cellular components related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	apical plasma membrane	GO:0016324	9.13	MUC1 ERBB2 CEACAM5
2	endosome lumen	GO:0031904	8.62	PRLR PRL

Biological processes related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lactation	GO:0007595	9.16	PRLR PRL
2	mammary gland development	GO:0030879	8.96	PRL PGR
3	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	8.62	PRLR PRL

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Sources for Lipid-Rich Breast Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹³ diseasecard

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

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⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia