Lipid-Rich Breast Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lipid-Rich Breast Carcinoma

MalaCards integrated aliases for Lipid-Rich Breast Carcinoma:

Name: Lipid-Rich Breast Carcinoma ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7076

NCIt ⁴⁹ C40365

UMLS ⁷¹ C1517894

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Summaries for Lipid-Rich Breast Carcinoma

Disease Ontology : ¹² A lipid-rich carcinoma characterized by the presence of cytoplasmic neutral lipids in the vast majority of the malignant cells.

MalaCards based summary : Lipid-Rich Breast Carcinoma is related to glassy cell carcinoma of the cervix and scirrhous adenocarcinoma, and has symptoms including pain An important gene associated with Lipid-Rich Breast Carcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Prolactin Signaling Pathway and Signaling events mediated by PTP1B. Affiliated tissues include breast, ovary and pituitary, and related phenotypes are behavior/neurological and endocrine/exocrine gland

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Related Diseases for Lipid-Rich Breast Carcinoma

Diseases related to Lipid-Rich Breast Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)

#	Related Disease	Score	Top Affiliating Genes
1	glassy cell carcinoma of the cervix	10.3	PGR ERBB2
2	scirrhous adenocarcinoma	10.3	PGR ERBB2
3	breast juvenile papillomatosis	10.3	PGR ERBB2
4	oncocytic breast carcinoma	10.3	PGR ERBB2
5	apocrine adenosis of breast	10.2	PGR ERBB2
6	serous cystadenocarcinoma	10.2	PGR ERBB2
7	comedo carcinoma	10.2	PGR ERBB2
8	breast adenoid cystic carcinoma	10.2	PGR ERBB2
9	linitis plastica	10.2	PGR ERBB2
10	glycogen-rich clear cell breast carcinoma	10.2	PRLR PGR
11	sweat gland neoplasm	10.2	KRT5 ERBB2
12	progesterone-receptor negative breast cancer	10.2	PGR ERBB2
13	breast sarcoma	10.2	PGR ERBB2
14	primary peritoneal carcinoma	10.2	PGR ERBB2
15	breast neuroendocrine neoplasm	10.2	PGR ERBB2
16	breast cystic hypersecretory carcinoma	10.2	KRT5 ERBB2
17	vulva basal cell carcinoma	10.2	KRT5 ERBB2
18	progesterone-receptor positive breast cancer	10.2	PGR ERBB2
19	vulvar disease	10.2	PGR ERBB2
20	hypertrophy of breast	10.2	PGR ERBB2
21	cerebral meningioma	10.2	PRLR PGR
22	female reproductive endometrioid cancer	10.2	PGR ERBB2
23	galactorrhea	10.2	PRLR PRL
24	esophageal adenosquamous carcinoma	10.2	KRT5 ERBB2
25	adenosarcoma	10.2	PGR ERBB2
26	inflammatory breast carcinoma	10.2	PGR ERBB2
27	chromophobe adenoma	10.2	PRLR PRL
28	granulosa cell tumor of the ovary	10.2	PRL ERBB2
29	breast adenoma	10.2	PRLR PRL
30	peritoneum cancer	10.1	KRT5 ERBB2
31	pregnancy adenoma	10.1	PGR KRT5
32	external ear carcinoma	10.1	PGR KRT5
33	bilateral breast cancer	10.1	PGR ERBB2
34	large cell neuroendocrine carcinoma	10.1	PGR ERBB2
35	eccrine papillary adenocarcinoma	10.1	PGR KRT5
36	uterine corpus cancer	10.1	PGR ERBB2
37	pyometritis	10.1	PRL PGR
38	mammographic density	10.1	PRL PGR
39	breast myoepithelial carcinoma	10.1	PGR KRT5
40	sebaceous adenocarcinoma	10.1	KRT5 ERBB2
41	polyp of corpus uteri	10.1	PRL PGR
42	rete ovarii adenoma	10.1	PRL PGR
43	rete ovarii neoplasm	10.1	PRL PGR
44	cutaneous adenocystic carcinoma	10.1	PGR KRT5
45	amelogenesis imperfecta, type ig	10.1	PGR ERBB2
46	uterus leiomyosarcoma	10.1	PGR KRT5
47	estrogen-receptor negative breast cancer	10.1	PGR ERBB2
48	estrogen excess	10.1	PRL PGR
49	functioning pituitary adenoma	10.1	PRLR PRL
50	chronic tympanitis	10.1	PGR MUC1

Graphical network of the top 20 diseases related to Lipid-Rich Breast Carcinoma:

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Symptoms & Phenotypes for Lipid-Rich Breast Carcinoma

UMLS symptoms related to Lipid-Rich Breast Carcinoma:

pain

MGI Mouse Phenotypes related to Lipid-Rich Breast Carcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.8	ERBB2 KRT5 MRAP PGR PRL PRLR
2	endocrine/exocrine gland	MP:0005379	9.65	ERBB2 MRAP PGR PRL PRLR
3	integument	MP:0010771	9.55	ERBB2 KRT5 PGR PRL PRLR
4	limbs/digits/tail	MP:0005371	9.26	ERBB2 KRT5 PGR PRLR
5	neoplasm	MP:0002006	8.92	ERBB2 PGR PRL PRLR

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Drugs & Therapeutics for Lipid-Rich Breast Carcinoma

Search Clinical Trials , NIH Clinical Center for Lipid-Rich Breast Carcinoma

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Genetic Tests for Lipid-Rich Breast Carcinoma

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Anatomical Context for Lipid-Rich Breast Carcinoma

MalaCards organs/tissues related to Lipid-Rich Breast Carcinoma:

⁴⁰

Breast, Ovary, Pituitary, Small Intestine, Salivary Gland, Uterus, Cervix

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Publications for Lipid-Rich Breast Carcinoma

Articles related to Lipid-Rich Breast Carcinoma:

#	Title	Authors	PMID	Year
1	Clear cell carcinoma of breast lipid-rich variant. ⁶¹	Kini H...Thomas M	31603128	2019
2	Lipid-rich carcinoma of the breast: a case report. ⁶¹	Shi P...Sun JZ	18411586	2008
3	Pathologic quiz case: a 62-year-old woman with a 4.5-cm nodule in the right breast. Lipid-rich breast carcinoma. ⁶¹	Reis-Filho JS...Schmitt FC	12951994	2003

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Genes for Lipid-Rich Breast Carcinoma

Genes related to Lipid-Rich Breast Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	5.03	DISEASES inferred ¹⁵
2	PRLR	Prolactin Receptor	Protein Coding	4.79	DISEASES inferred ¹⁵
3	PGR	Progesterone Receptor	Protein Coding	4	DISEASES inferred ¹⁵
4	KRT5	Keratin 5	Protein Coding	3.86	DISEASES inferred ¹⁵
5	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	3.54	DISEASES inferred ¹⁵
6	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	3.49	DISEASES inferred ¹⁵
7	PRL	Prolactin	Protein Coding	3.49	DISEASES inferred ¹⁵

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Variations for Lipid-Rich Breast Carcinoma

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Expression for Lipid-Rich Breast Carcinoma

Search GEO for disease gene expression data for Lipid-Rich Breast Carcinoma.

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Pathways for Lipid-Rich Breast Carcinoma

Pathways related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Prolactin Signaling Pathway ¹ ³⁶ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	11.78	PRLR PRL ERBB2
2	Signaling events mediated by PTP1B ¹	11.02	PRLR PRL
3	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	10.96	PRLR PRL PGR ERBB2
4	Growth hormone receptor signaling ⁶⁵ Show member pathways Prolactin receptor signaling ⁶⁵	10.87	PRLR PRL
5	Ovarian Infertility Genes ¹	10.46	PRLR PGR

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GO Terms for Lipid-Rich Breast Carcinoma

Cellular components related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endosome lumen	GO:0031904	8.62	PRLR PRL

Biological processes related to Lipid-Rich Breast Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lactation	GO:0007595	9.26	PRLR PRL
2	mammary gland development	GO:0030879	9.16	PRL PGR
3	cell surface receptor signaling pathway	GO:0007166	9.13	PRLR PRL ERBB2
4	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	8.62	PRLR PRL

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Sources for Lipid-Rich Breast Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁹ TGDB

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⁷¹ UMLS

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia