MCID: LPD003
MIFTS: 34

Lipid-Rich Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Lipid-Rich Carcinoma

MalaCards integrated aliases for Lipid-Rich Carcinoma:

Name: Lipid-Rich Carcinoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5658
NCIt 51 C4152
SNOMED-CT 69 3839000
UMLS 74 C0334318

Summaries for Lipid-Rich Carcinoma

Disease Ontology : 12 A breast carcinoma characterized by the presence of malignant epithelial cells with clear cytoplasm which contains neutral lipids.

MalaCards based summary : Lipid-Rich Carcinoma is related to lipid-rich breast carcinoma and epidermolysis bullosa simplex, localized. An important gene associated with Lipid-Rich Carcinoma is PLIN2 (Perilipin 2), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include breast, and related phenotypes are Increased cell death HMECs cells and endocrine/exocrine gland

Related Diseases for Lipid-Rich Carcinoma

Diseases related to Lipid-Rich Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 lipid-rich breast carcinoma 11.3
2 epidermolysis bullosa simplex, localized 10.5 KRT14 KRT5
3 epidermolysis bullosa simplex, generalized 10.5 KRT14 KRT5
4 epidermolysis bullosa simplex with mottled pigmentation 10.5 KRT14 KRT5
5 peritoneal benign neoplasm 10.5 ESR1 PGR
6 gender identity disorder 10.5 ESR1 PGR
7 endometrial mucinous adenocarcinoma 10.5 ESR1 PGR
8 deep angioma 10.5 ESR1 PGR
9 endometrial squamous cell carcinoma 10.5 ESR1 PGR
10 cribriform carcinoma 10.5 ESR1 PGR
11 diffuse peritoneal leiomyomatosis 10.5 ESR1 PGR
12 scirrhous adenocarcinoma 10.4 ERBB2 PGR
13 non-proliferative fibrocystic change of the breast 10.4 ERBB2 TP53
14 uterine corpus serous adenocarcinoma 10.4 ERBB2 TP53
15 breast apocrine carcinoma 10.4 ERBB2 PGR
16 papillary serous adenocarcinoma 10.4 PGR TP53
17 olfactory groove meningioma 10.4 PGR TP53
18 vestibular gland benign neoplasm 10.4 ESR1 PGR
19 bartholin's gland adenoma 10.4 ESR1 PGR
20 intracystic papillary adenoma 10.4 ERBB2 PGR
21 vulvar syringoma 10.4 ESR1 PGR
22 lung leiomyoma 10.4 ESR1 PGR
23 endometrium carcinoma in situ 10.4 PGR TP53
24 breast intraductal proliferative lesion 10.4 EGFR ERBB2
25 vulvar benign neoplasm 10.4 ESR1 PGR
26 trigonitis 10.4 ESR1 PGR
27 vulvar leiomyoma 10.4 ESR1 PGR
28 vulval paget's disease 10.3 ERBB2 PIP
29 esophageal adenosquamous carcinoma 10.3 CDH1 KRT5
30 breast metaplastic carcinoma 10.3 ERBB2 KRT5 PGR
31 lichen planopilaris 10.3 KRT14 KRT5
32 gastric papillary adenocarcinoma 10.3 ERBB2 TP53
33 epidermolysis bullosa simplex, autosomal recessive 1 10.3 KRT14 KRT5
34 comedo carcinoma 10.3 ERBB2 ESR1
35 apocrine sweat gland neoplasm 10.3 KRT14 KRT5 MFGE8
36 sweat gland disease 10.3 KRT14 KRT5 PGR
37 glassy cell carcinoma of the cervix 10.3 ERBB2 ESR1 PGR
38 malignant spiradenoma 10.3 KRT5 TP53
39 breast medullary carcinoma 10.3 ERBB2 ESR1 PGR
40 progesterone-receptor positive breast cancer 10.3 ERBB2 ESR1 PGR
41 eccrine adenocarcinoma 10.3 ESR1 PIP
42 breast adenoid cystic carcinoma 10.3 ERBB2 ESR1 PGR
43 breast adenomyoepithelioma 10.3 CDH1 KRT14 KRT5
44 spiradenoma 10.3 KRT14 TP53
45 predominantly cortical thymoma 10.3 ESR1 KRT14 PGR
46 carcinosarcoma 10.3 ERBB2 PGR TP53
47 brain ependymoma 10.3 EGFR TP53
48 breast neuroendocrine neoplasm 10.3 ERBB2 PIP
49 breast myoepithelial neoplasm 10.3 CDH1 KRT14 KRT5
50 estrogen-receptor negative breast cancer 10.3 ERBB2 ESR1 PGR

Graphical network of the top 20 diseases related to Lipid-Rich Carcinoma:



Diseases related to Lipid-Rich Carcinoma

Symptoms & Phenotypes for Lipid-Rich Carcinoma

GenomeRNAi Phenotypes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.02 EGFR MFGE8 PGR PIP TP53

MGI Mouse Phenotypes related to Lipid-Rich Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.22 CDH1 CSN2 EGFR ERBB2 ESR1 KRT14
2 cellular MP:0005384 10.2 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
3 integument MP:0010771 10.13 CDH1 CSN2 EGFR ERBB2 ESR1 KRT14
4 immune system MP:0005387 10.07 CDH1 EGFR ESR1 KRT14 MFGE8 PGR
5 digestive/alimentary MP:0005381 10.03 CDH1 EGFR ERBB2 ESR1 KRT14 KRT5
6 adipose tissue MP:0005375 9.95 EGFR ESR1 KRT14 PLIN2 PRLR TP53
7 neoplasm MP:0002006 9.85 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
8 limbs/digits/tail MP:0005371 9.8 EGFR ERBB2 ESR1 KRT5 PGR PRLR
9 normal MP:0002873 9.61 CDH1 EGFR ERBB2 ESR1 ITLN1 LALBA
10 reproductive system MP:0005389 9.36 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8

Drugs & Therapeutics for Lipid-Rich Carcinoma

Search Clinical Trials , NIH Clinical Center for Lipid-Rich Carcinoma

Genetic Tests for Lipid-Rich Carcinoma

Anatomical Context for Lipid-Rich Carcinoma

MalaCards organs/tissues related to Lipid-Rich Carcinoma:

42
Breast

Publications for Lipid-Rich Carcinoma

Articles related to Lipid-Rich Carcinoma:

(show all 20)
# Title Authors Year
1
Lipid-Rich Carcinoma of the Breast With Unusual Clinical and Histopathological Features. ( 26920701 )
2016
2
Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review. ( 27051299 )
2016
3
Lipid-rich carcinoma of male breast in Chinese: a case report and literature review. ( 26064365 )
2015
4
Lipid-rich carcinoma of the breast: A report of two cases and a literature review. ( 25789031 )
2015
5
Unusual occurrence of rare lipid-rich carcinoma and conventional invasive ductal carcinoma in the one breast: case report. ( 23050179 )
2012
6
Intraductal lipid-rich carcinoma of the breast with a component of glycogen-rich carcinoma. ( 22493642 )
2012
7
Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog. ( 22261147 )
2012
8
A case report of lipid-rich carcinoma of the breast including histological characteristics and intrinsic subtype profile. ( 21734882 )
2011
9
Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases. ( 21396871 )
2011
10
Intracytoplasmic lipid accumulation in apocrine carcinoma of the breast evaluated with adipophilin immunoreactivity: a possible link between apocrine carcinoma and lipid-rich carcinoma. ( 21566511 )
2011
11
Imprint cytology of primary ethmoidal lipid-rich carcinoma combined with adipophilin immunocytochemistry. ( 20132263 )
2010
12
Lipid-rich carcinoma in the mammary gland of a Djungarian hamster (Phodopus sungorus). ( 20224099 )
2010
13
Ethmoidal lipid-rich carcinoma with focal glandular structures. ( 19451474 )
2009
14
Lipid-rich carcinoma of breast: a case report with fine needle aspiration cytology. ( 19795489 )
2009
15
Lipid-rich carcinoma of the breast. A clinicopathological study of 49 cases. ( 18705401 )
2008
16
Lipid-rich carcinoma of the breast: a case report. ( 18411586 )
2008
17
Lipid-rich carcinoma of the mammary gland in a cat. ( 15872384 )
2005
18
Metaplastic lipid-rich carcinoma of the breast. ( 9832063 )
1998
19
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast. ( 2845641 )
1988
20
Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examples. ( 4815583 )
1974

Variations for Lipid-Rich Carcinoma

Expression for Lipid-Rich Carcinoma

Search GEO for disease gene expression data for Lipid-Rich Carcinoma.

Pathways for Lipid-Rich Carcinoma

Pathways related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.66 CDH1 EGFR ERBB2 ESR1 TP53
2
Show member pathways
12.47 CDH1 EGFR ERBB2 ESR1 TP53
3
Show member pathways
12.4 CDH1 EGFR ERBB2 ESR1 PGR TP53
4
Show member pathways
12.3 CSN2 ERBB2 ESR1 PRLR
5 12.06 EGFR ERBB2 ESR1 TP53
6 11.89 CDH1 EGFR ESR1 TP53
7
Show member pathways
11.84 EGFR ERBB2 TP53
8
Show member pathways
11.7 EGFR ERBB2 ESR1
9 11.56 CDH1 EGFR ERBB2
10
Show member pathways
11.53 EGFR ESR1 PRLR
11 11.48 EGFR ERBB2 TP53
12 11.37 CSN2 KRT14 KRT5 TP53
13 11.31 CSN2 EGFR PRLR
14
Show member pathways
11.13 CSN2 EGFR ERBB2 ESR1 PGR PRLR
15 11.12 CDH1 EGFR ERBB2 TP53
16 11.04 CDH1 EGFR ERBB2
17 10.97 EGFR ERBB2 MFGE8
18 10.85 CDH1 EGFR

GO Terms for Lipid-Rich Carcinoma

Cellular components related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 CDH1 ITLN1 KRT14 KRT5 MFGE8 PIP
2 extracellular region GO:0005576 9.36 CDH1 CSN2 EGFR ITLN1 LALBA MFGE8
3 receptor complex GO:0043235 9.26 EGFR ERBB2 ITLN1 PRLR

Biological processes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.54 EGFR ERBB2 ESR1
2 epidermis development GO:0008544 9.5 EGFR KRT14 KRT5
3 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
4 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 ESR1 TP53
5 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.96 EGFR TP53
6 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.72 CDH1 CSN2 ITLN1 LALBA S100A4
2 protein phosphatase binding GO:0019903 9.43 EGFR ERBB2 TP53
3 identical protein binding GO:0042802 9.28 CDH1 EGFR ERBB2 ESR1 ITLN1 PGR
4 nitric-oxide synthase regulator activity GO:0030235 9.16 EGFR ESR1
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 EGFR ERBB2 ESR1

Sources for Lipid-Rich Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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