MCID: LPD003
MIFTS: 36

Lipid-Rich Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Lipid-Rich Carcinoma

MalaCards integrated aliases for Lipid-Rich Carcinoma:

Name: Lipid-Rich Carcinoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5658
NCIt 51 C4152
SNOMED-CT 69 3839000
UMLS 74 C0334318

Summaries for Lipid-Rich Carcinoma

Disease Ontology : 12 A breast carcinoma characterized by the presence of malignant epithelial cells with clear cytoplasm which contains neutral lipids.

MalaCards based summary : Lipid-Rich Carcinoma is related to glycogen-rich clear cell breast carcinoma and apocrine adenocarcinoma. An important gene associated with Lipid-Rich Carcinoma is PLIN2 (Perilipin 2), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include breast, lung and ovary, and related phenotypes are Increased cell death HMECs cells and endocrine/exocrine gland

Related Diseases for Lipid-Rich Carcinoma

Diseases related to Lipid-Rich Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 glycogen-rich clear cell breast carcinoma 30.2 ESR1 PGR TP53
2 apocrine adenocarcinoma 30.1 ERBB2 ESR1 KRT5 PGR
3 lipid-rich breast carcinoma 11.3
4 epidermolysis bullosa simplex, localized 10.5 KRT14 KRT5
5 epidermolysis bullosa simplex, generalized 10.5 KRT14 KRT5
6 epidermolysis bullosa simplex with mottled pigmentation 10.5 KRT14 KRT5
7 peritoneal benign neoplasm 10.5 ESR1 PGR
8 gender identity disorder 10.5 ESR1 PGR
9 endometrial mucinous adenocarcinoma 10.5 ESR1 PGR
10 deep angioma 10.5 ESR1 PGR
11 endometrial squamous cell carcinoma 10.5 ESR1 PGR
12 cribriform carcinoma 10.5 ESR1 PGR
13 diffuse peritoneal leiomyomatosis 10.5 ESR1 PGR
14 scirrhous adenocarcinoma 10.5 ERBB2 PGR
15 non-proliferative fibrocystic change of the breast 10.5 ERBB2 TP53
16 uterine corpus serous adenocarcinoma 10.5 ERBB2 TP53
17 breast apocrine carcinoma 10.4 ERBB2 PGR
18 papillary serous adenocarcinoma 10.4 PGR TP53
19 olfactory groove meningioma 10.4 PGR TP53
20 vestibular gland benign neoplasm 10.4 ESR1 PGR
21 bartholin's gland adenoma 10.4 ESR1 PGR
22 intracystic papillary adenoma 10.4 ERBB2 PGR
23 vulvar syringoma 10.4 ESR1 PGR
24 lung leiomyoma 10.4 ESR1 PGR
25 endometrium carcinoma in situ 10.4 PGR TP53
26 vulvar benign neoplasm 10.4 ESR1 PGR
27 trigonitis 10.4 ESR1 PGR
28 vulvar leiomyoma 10.4 ESR1 PGR
29 breast intraductal proliferative lesion 10.4 EGFR ERBB2
30 vulval paget's disease 10.4 ERBB2 PIP
31 esophageal adenosquamous carcinoma 10.4 CDH1 KRT5
32 breast metaplastic carcinoma 10.3 ERBB2 KRT5 PGR
33 lichen planopilaris 10.3 KRT14 KRT5
34 gastric papillary adenocarcinoma 10.3 ERBB2 TP53
35 epidermolysis bullosa simplex, autosomal recessive 1 10.3 KRT14 KRT5
36 comedo carcinoma 10.3 ERBB2 ESR1
37 apocrine sweat gland neoplasm 10.3 KRT14 KRT5 MFGE8
38 sweat gland disease 10.3 KRT14 KRT5 PGR
39 glassy cell carcinoma of the cervix 10.3 ERBB2 ESR1 PGR
40 malignant spiradenoma 10.3 KRT5 TP53
41 breast medullary carcinoma 10.3 ERBB2 ESR1 PGR
42 progesterone-receptor positive breast cancer 10.3 ERBB2 ESR1 PGR
43 eccrine adenocarcinoma 10.3 ESR1 PIP
44 breast adenoid cystic carcinoma 10.3 ERBB2 ESR1 PGR
45 breast adenomyoepithelioma 10.3 CDH1 KRT14 KRT5
46 spiradenoma 10.3 KRT14 TP53
47 predominantly cortical thymoma 10.3 ESR1 KRT14 PGR
48 carcinosarcoma 10.3 ERBB2 PGR TP53
49 breast neuroendocrine neoplasm 10.3 ERBB2 PIP
50 breast myoepithelial neoplasm 10.3 CDH1 KRT14 KRT5

Graphical network of the top 20 diseases related to Lipid-Rich Carcinoma:



Diseases related to Lipid-Rich Carcinoma

Symptoms & Phenotypes for Lipid-Rich Carcinoma

GenomeRNAi Phenotypes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 9.02 EGFR MFGE8 PGR PIP TP53

MGI Mouse Phenotypes related to Lipid-Rich Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.22 CDH1 CSN2 EGFR ERBB2 ESR1 KRT14
2 cellular MP:0005384 10.2 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
3 integument MP:0010771 10.13 CDH1 CSN2 EGFR ERBB2 ESR1 KRT14
4 immune system MP:0005387 10.07 CDH1 EGFR ESR1 KRT14 MFGE8 PGR
5 digestive/alimentary MP:0005381 10.03 CDH1 EGFR ERBB2 ESR1 KRT14 KRT5
6 adipose tissue MP:0005375 9.95 EGFR ESR1 KRT14 PLIN2 PRLR TP53
7 neoplasm MP:0002006 9.85 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
8 limbs/digits/tail MP:0005371 9.8 EGFR ERBB2 ESR1 KRT5 PGR PRLR
9 normal MP:0002873 9.61 CDH1 EGFR ERBB2 ESR1 ITLN1 LALBA
10 reproductive system MP:0005389 9.36 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8

Drugs & Therapeutics for Lipid-Rich Carcinoma

Search Clinical Trials , NIH Clinical Center for Lipid-Rich Carcinoma

Genetic Tests for Lipid-Rich Carcinoma

Anatomical Context for Lipid-Rich Carcinoma

MalaCards organs/tissues related to Lipid-Rich Carcinoma:

42
Breast, Lung, Ovary, Brain, Colon, Bone, Pancreas

Publications for Lipid-Rich Carcinoma

Articles related to Lipid-Rich Carcinoma:

(show all 20)
# Title Authors Year
1
Lipid-Rich Carcinoma of the Breast With Unusual Clinical and Histopathological Features. ( 26920701 )
2016
2
Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review. ( 27051299 )
2016
3
Lipid-rich carcinoma of the breast: A report of two cases and a literature review. ( 25789031 )
2015
4
Lipid-rich carcinoma of male breast in Chinese: a case report and literature review. ( 26064365 )
2015
5
Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog. ( 22261147 )
2012
6
Intraductal lipid-rich carcinoma of the breast with a component of glycogen-rich carcinoma. ( 22493642 )
2012
7
Unusual occurrence of rare lipid-rich carcinoma and conventional invasive ductal carcinoma in the one breast: case report. ( 23050179 )
2012
8
Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases. ( 21396871 )
2011
9
Intracytoplasmic lipid accumulation in apocrine carcinoma of the breast evaluated with adipophilin immunoreactivity: a possible link between apocrine carcinoma and lipid-rich carcinoma. ( 21566511 )
2011
10
A case report of lipid-rich carcinoma of the breast including histological characteristics and intrinsic subtype profile. ( 21734882 )
2011
11
Imprint cytology of primary ethmoidal lipid-rich carcinoma combined with adipophilin immunocytochemistry. ( 20132263 )
2010
12
Lipid-rich carcinoma in the mammary gland of a Djungarian hamster (Phodopus sungorus). ( 20224099 )
2010
13
Ethmoidal lipid-rich carcinoma with focal glandular structures. ( 19451474 )
2009
14
Lipid-rich carcinoma of breast: a case report with fine needle aspiration cytology. ( 19795489 )
2009
15
Lipid-rich carcinoma of the breast: a case report. ( 18411586 )
2008
16
Lipid-rich carcinoma of the breast. A clinicopathological study of 49 cases. ( 18705401 )
2008
17
Lipid-rich carcinoma of the mammary gland in a cat. ( 15872384 )
2005
18
Metaplastic lipid-rich carcinoma of the breast. ( 9832063 )
1998
19
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast. ( 2845641 )
1988
20
Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examples. ( 4815583 )
1974

Variations for Lipid-Rich Carcinoma

Expression for Lipid-Rich Carcinoma

Search GEO for disease gene expression data for Lipid-Rich Carcinoma.

Pathways for Lipid-Rich Carcinoma

Pathways related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.66 CDH1 EGFR ERBB2 ESR1 TP53
2
Show member pathways
12.47 CDH1 EGFR ERBB2 ESR1 TP53
3
Show member pathways
12.4 CDH1 EGFR ERBB2 ESR1 PGR TP53
4
Show member pathways
12.35 CDH1 EGFR ERBB2 TP53
5
Show member pathways
12.3 CSN2 ERBB2 ESR1 PRLR
6 12.06 EGFR ERBB2 ESR1 TP53
7 11.89 CDH1 EGFR ESR1 TP53
8
Show member pathways
11.85 EGFR ERBB2 TP53
9
Show member pathways
11.7 EGFR ERBB2 ESR1
10 11.56 CDH1 EGFR ERBB2
11
Show member pathways
11.53 EGFR ESR1 PRLR
12 11.48 EGFR ERBB2 TP53
13 11.37 CSN2 KRT14 KRT5 TP53
14 11.31 CSN2 EGFR PRLR
15
Show member pathways
11.13 CSN2 EGFR ERBB2 ESR1 PGR PRLR
16 11.12 CDH1 EGFR ERBB2 TP53
17 11.04 CDH1 EGFR ERBB2
18 10.97 EGFR ERBB2 MFGE8
19 10.86 CDH1 EGFR

GO Terms for Lipid-Rich Carcinoma

Cellular components related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 CDH1 ITLN1 KRT14 KRT5 MFGE8 PIP
2 extracellular region GO:0005576 9.36 CDH1 CSN2 EGFR ITLN1 LALBA MFGE8
3 receptor complex GO:0043235 9.26 EGFR ERBB2 ITLN1 PRLR

Biological processes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.5 EGFR KRT14 KRT5
2 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
3 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 ESR1 TP53
4 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.96 EGFR TP53
5 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.65 CDH1 CSN2 ITLN1 LALBA S100A4
2 protein phosphatase binding GO:0019903 9.33 EGFR ERBB2 TP53
3 identical protein binding GO:0042802 9.28 CDH1 EGFR ERBB2 ESR1 ITLN1 PGR
4 nitric-oxide synthase regulator activity GO:0030235 8.96 EGFR ESR1

Sources for Lipid-Rich Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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