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MCID: LPD003
MIFTS: 28

Lipid-Rich Carcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Lipid-Rich Carcinoma

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MalaCards integrated aliases for Lipid-Rich Carcinoma:

Name: Lipid-Rich Carcinoma 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases
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External Ids:

Disease Ontology 12 DOID:5658
NCIt 49 C4152
SNOMED-CT 67 3839000
UMLS 71 C0334318
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Summaries for Lipid-Rich Carcinoma

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Disease Ontology : 12 A breast carcinoma characterized by the presence of malignant epithelial cells with clear cytoplasm which contains neutral lipids.

MalaCards based summary : Lipid-Rich Carcinoma is related to lipid-rich breast carcinoma and glycogen-rich clear cell breast carcinoma. An important gene associated with Lipid-Rich Carcinoma is PLIN2 (Perilipin 2), and among its related pathways/superpathways are Gastric cancer and Prolactin Signaling Pathway. Affiliated tissues include breast, skin and ovary, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and endocrine/exocrine gland

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Related Diseases for Lipid-Rich Carcinoma

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Diseases related to Lipid-Rich Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 lipid-rich breast carcinoma 32.3 PRLR PGR KRT5 ERBB2
2 glycogen-rich clear cell breast carcinoma 30.0 PRLR PIP PGR
3 breast adenocarcinoma 29.4 PIP PGR ESR1 ERBB2
4 apocrine adenocarcinoma 28.3 PIP PGR KRT5 KRT14 ESR1 ERBB2
5 in situ carcinoma 27.7 PIP PGR KRT5 KRT14 ESR1 ERBB2
6 ductal carcinoma in situ 27.7 PIP PGR KRT5 KRT14 ESR1 ERBB2
7 breast cancer 26.6 PRLR PIP PGR KRT5 KRT14 ESR1
8 rapidly involuting congenital hemangioma 10.6
9 vulval paget's disease 10.4 PIP ERBB2
10 vulva adenocarcinoma 10.4 PIP ERBB2
11 submandibular gland cancer 10.4 PIP ERBB2
12 acute thyroiditis 10.4 PIP LALBA
13 eyelid carcinoma 10.4 PIP LALBA
14 apocrine adenosis of breast 10.3 PGR ERBB2
15 bartholin's gland disease 10.3 PIP PGR
16 breast adenoid cystic carcinoma 10.3 PGR ERBB2
17 vulva basal cell carcinoma 10.3 KRT5 ERBB2
18 ceruminoma 10.3 PIP KRT5
19 primary peritoneal carcinoma 10.3 PGR ERBB2
20 vulvar apocrine adenocarcinoma 10.3 PIP KRT5
21 clear cell hidradenoma 10.3 PIP KRT5
22 hidradenoma 10.3 PIP KRT5
23 eccrine sweat gland cancer 10.3 PIP KRT5
24 eccrine acrospiroma 10.2 PIP KRT5
25 external ear carcinoma 10.2 PGR KRT5
26 eccrine papillary adenoma 10.2 PIP KRT14
27 cerebral meningioma 10.2 PRLR PGR
28 cervical clear cell adenocarcinoma 10.2 PGR KRT14
29 peritoneum cancer 10.2 KRT5 ERBB2
30 uterus leiomyosarcoma 10.2 PGR KRT5
31 polyp of corpus uteri 10.2 PGR KRT14
32 rete ovarii adenoma 10.2 PGR KRT14
33 rete ovarii neoplasm 10.1 PGR KRT14
34 vulvar disease 10.1 PIP PGR ERBB2
35 benign breast adenomyoepithelioma 10.1 KRT5 KRT14
36 bartholin's gland adenoid cystic carcinoma 10.1 PGR ESR1
37 breast adenomyoepithelioma 10.1 KRT5 KRT14
38 chronic tympanitis 10.1 PGR ESR1
39 sebaceous adenoma 10.1 PLIN2 ESR1
40 bartholin's gland adenoma 10.1 PGR ESR1
41 granulomatous endometritis 10.1 PGR ESR1
42 bartholin's gland benign neoplasm 10.1 PGR ESR1
43 vestibular gland benign neoplasm 10.1 PGR ESR1
44 breast adenoma 10.1 PRLR KRT14
45 esophageal basaloid squamous cell carcinoma 10.1 KRT5 KRT14
46 lung leiomyoma 10.1 PGR ESR1
47 trigonitis 10.1 PGR ESR1
48 vagina leiomyosarcoma 10.1 PGR ESR1
49 breast myoepithelial neoplasm 10.1 KRT5 KRT14
50 adult type testicular granulosa cell tumor 10.1 PGR ESR1

Graphical network of the top 20 diseases related to Lipid-Rich Carcinoma:



Diseases related to Lipid-Rich Carcinoma
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Symptoms & Phenotypes for Lipid-Rich Carcinoma

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GenomeRNAi Phenotypes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.8 CSN2 ESR1 PIP

MGI Mouse Phenotypes related to Lipid-Rich Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.02 CDH1 CSN2 ERBB2 ESR1 KRT14 LALBA
2 integument MP:0010771 9.96 CDH1 CSN2 ERBB2 ESR1 KRT14 KRT5
3 digestive/alimentary MP:0005381 9.85 CDH1 ERBB2 ESR1 KRT14 KRT5 PIP
4 limbs/digits/tail MP:0005371 9.55 ERBB2 ESR1 KRT5 PGR PRLR
5 neoplasm MP:0002006 9.43 CDH1 ERBB2 ESR1 KRT14 PGR PRLR
6 reproductive system MP:0005389 9.23 CDH1 ERBB2 ESR1 KRT14 PGR PIP
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Drugs & Therapeutics for Lipid-Rich Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lipid-Rich Carcinoma

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Genetic Tests for Lipid-Rich Carcinoma

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Anatomical Context for Lipid-Rich Carcinoma

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MalaCards organs/tissues related to Lipid-Rich Carcinoma:

40
Breast, Skin, Ovary, Thyroid, Lung, Liver, Uterus
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Publications for Lipid-Rich Carcinoma

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Articles related to Lipid-Rich Carcinoma:

(show all 36)
# Title Authors PMID Year
1
Clinicopathologic characteristics of mixed epithelial/mesenchymal metaplastic breast carcinoma (carcinosarcoma): a meta-analysis of Chinese patients. 61
31820860 2019
2
Clinicopathological characteristics of breast sebaceous adenocarcinoma. 61
30509049 2018
3
Lipid-Rich Carcinoma of the Breast With Unusual Clinical and Histopathological Features. 61
26920701 2016
4
Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review. 61
27051299 2016
5
Characterization of Spontaneous Mammary Tumors in Domestic Djungarian Hamsters (Phodopus sungorus). 61
25967136 2015
6
Sebaceous carcinoma of the breast: report of four cases and review of the literature. 61
26247527 2015
7
Lipid-rich carcinoma of the breast: A report of two cases and a literature review. 61
25789031 2015
8
Lipid-rich carcinoma of male breast in Chinese: a case report and literature review. 61
26064365 2015
9
Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog. 61
22261147 2012
10
Intraductal lipid-rich carcinoma of the breast with a component of glycogen-rich carcinoma. 61
22493642 2012
11
Unusual occurrence of rare lipid-rich carcinoma and conventional invasive ductal carcinoma in the one breast: case report. 61
23050179 2012
12
Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases. 61
21396871 2011
13
Intracytoplasmic lipid accumulation in apocrine carcinoma of the breast evaluated with adipophilin immunoreactivity: a possible link between apocrine carcinoma and lipid-rich carcinoma. 61
21566511 2011
14
A case report of lipid-rich carcinoma of the breast including histological characteristics and intrinsic subtype profile. 61
21734882 2011
15
Imprint cytology of primary ethmoidal lipid-rich carcinoma combined with adipophilin immunocytochemistry. 61
20132263 2010
16
Lipid-rich carcinoma in the mammary gland of a Djungarian hamster (Phodopus sungorus). 61
20224099 2010
17
Lipid-rich histology in a basal-type immuno-profile breast carcinoma: a clinicopathological histochemical and immunohistochemical analysis of a case. 61
21139920 2009
18
Lipid-rich carcinoma of breast: a case report with fine needle aspiration cytology. 61
19795489 2009
19
Ethmoidal lipid-rich carcinoma with focal glandular structures. 61
19451474 2009
20
Xanthogranulomatous mastitis: clinicopathology and pathological implications. 61
19351366 2009
21
Lipid-rich carcinoma of the breast. A clinicopathological study of 49 cases. 61
18705401 2008
22
Lipid-rich carcinoma of the breast: a case report. 61
18411586 2008
23
Cytomorphology of rare malignant tumors of the breast. 61
16308090 2005
24
Lipid-rich carcinoma of the mammary gland in a cat. 61
15872384 2005
25
E-cadherin immunohistochemical analysis of histiocytoid carcinoma of the breast. 61
12089723 2002
26
Metaplastic lipid-rich carcinoma of the breast. 61
9832063 1998
27
Lipid-Secreting Carcinoma of the Breast: A Case Report and Review of the Literature. 61
11091643 1998
28
The problematic interpretation of foamy cells in breast fine needle aspirates. A report of two cases. 61
9100799 1997
29
Lipid secreting breast carcinoma in childhood: a case report. 61
8466877 1993
30
Fine-needle aspiration of an apocrine breast carcinoma with multivacuolated, lipid-rich, giant cells. 61
3378488 1988
31
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast. 61
2845641 1988
32
Breast cancer, chronic lymphocytic leukaemia and mucormycosis. 61
2831624 1987
33
Histiocytoid carcinoma: a variant of breast cancer. 61
2425190 1986
34
[Lipid-rich carcinoma of the breast--a case report]. 61
6525953 1984
35
Lipid-rich cell adenoma of the thyroid gland. Report of a peculiar thyroid tumour. 61
6433543 1984
36
Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examples. 61
4815583 1974
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Variations for Lipid-Rich Carcinoma

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Expression for Lipid-Rich Carcinoma

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Search GEO for disease gene expression data for Lipid-Rich Carcinoma.
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Pathways for Lipid-Rich Carcinoma

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Pathways related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Gastric cancer 36
Show member pathways
 12.22 PGR ESR1 ERBB2 CDH1
2
Prolactin Signaling Pathway 1 36
Show member pathways
 11.71 PRLR ESR1 ERBB2 CSN2
3
Glucocorticoid receptor regulatory network 1
11.25 KRT5 KRT14 CSN2
4
Signaling by ERBB4 65
Show member pathways
 11.05 PRLR PGR ESR1 ERBB2 CSN2
5
Ovarian Infertility Genes 1
10.87 PRLR PGR
6
a6b1 and a6b4 Integrin signaling 1
10.81 ERBB2 CDH1
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GO Terms for Lipid-Rich Carcinoma

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Biological processes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemidesmosome assembly GO:0031581 8.62 KRT5 KRT14

Molecular functions related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 PGR ESR1
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Sources for Lipid-Rich Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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