Lipid-Rich Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lipid-Rich Carcinoma

MalaCards integrated aliases for Lipid-Rich Carcinoma:

Name: Lipid-Rich Carcinoma ¹² ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5658

NCIt ⁵¹ C4152

SNOMED-CT ⁶⁹ 3839000

UMLS ⁷⁴ C0334318

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Summaries for Lipid-Rich Carcinoma

Disease Ontology : ¹² A breast carcinoma characterized by the presence of malignant epithelial cells with clear cytoplasm which contains neutral lipids.

MalaCards based summary : Lipid-Rich Carcinoma is related to glycogen-rich clear cell breast carcinoma and apocrine adenocarcinoma. An important gene associated with Lipid-Rich Carcinoma is PLIN2 (Perilipin 2), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include breast, lung and ovary, and related phenotypes are Increased cell death HMECs cells and endocrine/exocrine gland

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Related Diseases for Lipid-Rich Carcinoma

Diseases related to Lipid-Rich Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)

#	Related Disease	Score	Top Affiliating Genes
1	glycogen-rich clear cell breast carcinoma	30.2	ESR1 PGR TP53
2	apocrine adenocarcinoma	30.1	ERBB2 ESR1 KRT5 PGR
3	lipid-rich breast carcinoma	11.3
4	epidermolysis bullosa simplex, localized	10.5	KRT14 KRT5
5	epidermolysis bullosa simplex, generalized	10.5	KRT14 KRT5
6	epidermolysis bullosa simplex with mottled pigmentation	10.5	KRT14 KRT5
7	peritoneal benign neoplasm	10.5	ESR1 PGR
8	gender identity disorder	10.5	ESR1 PGR
9	endometrial mucinous adenocarcinoma	10.5	ESR1 PGR
10	deep angioma	10.5	ESR1 PGR
11	endometrial squamous cell carcinoma	10.5	ESR1 PGR
12	cribriform carcinoma	10.5	ESR1 PGR
13	diffuse peritoneal leiomyomatosis	10.5	ESR1 PGR
14	scirrhous adenocarcinoma	10.5	ERBB2 PGR
15	non-proliferative fibrocystic change of the breast	10.5	ERBB2 TP53
16	uterine corpus serous adenocarcinoma	10.5	ERBB2 TP53
17	breast apocrine carcinoma	10.4	ERBB2 PGR
18	papillary serous adenocarcinoma	10.4	PGR TP53
19	olfactory groove meningioma	10.4	PGR TP53
20	vestibular gland benign neoplasm	10.4	ESR1 PGR
21	bartholin's gland adenoma	10.4	ESR1 PGR
22	intracystic papillary adenoma	10.4	ERBB2 PGR
23	vulvar syringoma	10.4	ESR1 PGR
24	lung leiomyoma	10.4	ESR1 PGR
25	endometrium carcinoma in situ	10.4	PGR TP53
26	vulvar benign neoplasm	10.4	ESR1 PGR
27	trigonitis	10.4	ESR1 PGR
28	vulvar leiomyoma	10.4	ESR1 PGR
29	breast intraductal proliferative lesion	10.4	EGFR ERBB2
30	vulval paget's disease	10.4	ERBB2 PIP
31	esophageal adenosquamous carcinoma	10.4	CDH1 KRT5
32	breast metaplastic carcinoma	10.3	ERBB2 KRT5 PGR
33	lichen planopilaris	10.3	KRT14 KRT5
34	gastric papillary adenocarcinoma	10.3	ERBB2 TP53
35	epidermolysis bullosa simplex, autosomal recessive 1	10.3	KRT14 KRT5
36	comedo carcinoma	10.3	ERBB2 ESR1
37	apocrine sweat gland neoplasm	10.3	KRT14 KRT5 MFGE8
38	sweat gland disease	10.3	KRT14 KRT5 PGR
39	glassy cell carcinoma of the cervix	10.3	ERBB2 ESR1 PGR
40	malignant spiradenoma	10.3	KRT5 TP53
41	breast medullary carcinoma	10.3	ERBB2 ESR1 PGR
42	progesterone-receptor positive breast cancer	10.3	ERBB2 ESR1 PGR
43	eccrine adenocarcinoma	10.3	ESR1 PIP
44	breast adenoid cystic carcinoma	10.3	ERBB2 ESR1 PGR
45	breast adenomyoepithelioma	10.3	CDH1 KRT14 KRT5
46	spiradenoma	10.3	KRT14 TP53
47	predominantly cortical thymoma	10.3	ESR1 KRT14 PGR
48	carcinosarcoma	10.3	ERBB2 PGR TP53
49	breast neuroendocrine neoplasm	10.3	ERBB2 PIP
50	breast myoepithelial neoplasm	10.3	CDH1 KRT14 KRT5

Graphical network of the top 20 diseases related to Lipid-Rich Carcinoma:

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Symptoms & Phenotypes for Lipid-Rich Carcinoma

GenomeRNAi Phenotypes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell death HMECs cells	GR00103-A-0	9.02	EGFR MFGE8 PGR PIP TP53

MGI Mouse Phenotypes related to Lipid-Rich Carcinoma:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	10.22	CDH1 CSN2 EGFR ERBB2 ESR1 KRT14
2	cellular	MP:0005384	10.2	CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
3	integument	MP:0010771	10.13	CDH1 CSN2 EGFR ERBB2 ESR1 KRT14
4	immune system	MP:0005387	10.07	CDH1 EGFR ESR1 KRT14 MFGE8 PGR
5	digestive/alimentary	MP:0005381	10.03	CDH1 EGFR ERBB2 ESR1 KRT14 KRT5
6	adipose tissue	MP:0005375	9.95	EGFR ESR1 KRT14 PLIN2 PRLR TP53
7	neoplasm	MP:0002006	9.85	CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
8	limbs/digits/tail	MP:0005371	9.8	EGFR ERBB2 ESR1 KRT5 PGR PRLR
9	normal	MP:0002873	9.61	CDH1 EGFR ERBB2 ESR1 ITLN1 LALBA
10	reproductive system	MP:0005389	9.36	CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8

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Drugs & Therapeutics for Lipid-Rich Carcinoma

Search Clinical Trials , NIH Clinical Center for Lipid-Rich Carcinoma

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Genetic Tests for Lipid-Rich Carcinoma

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Anatomical Context for Lipid-Rich Carcinoma

MalaCards organs/tissues related to Lipid-Rich Carcinoma:

⁴²

Breast, Lung, Ovary, Brain, Colon, Bone, Pancreas

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Publications for Lipid-Rich Carcinoma

Articles related to Lipid-Rich Carcinoma:

(show all 20)

#	Title	Authors	Year
1	Lipid-Rich Carcinoma of the Breast With Unusual Clinical and Histopathological Features. ( 26920701 )	Gaspar BL...Vasishta RK	2016
2	Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review. ( 27051299 )	Oba T...Takayama F	2016
3	Lipid-rich carcinoma of the breast: A report of two cases and a literature review. ( 25789031 )	Cong Y...Zhu S	2015
4	Lipid-rich carcinoma of male breast in Chinese: a case report and literature review. ( 26064365 )	Xu S...Yang Z	2015
5	Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog. ( 22261147 )	Tei M...Nakayama H	2012
6	Intraductal lipid-rich carcinoma of the breast with a component of glycogen-rich carcinoma. ( 22493642 )	Kurisu Y...Nohara T	2012
7	Unusual occurrence of rare lipid-rich carcinoma and conventional invasive ductal carcinoma in the one breast: case report. ( 23050179 )	Machalekova K...Bencat M	2012
8	Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases. ( 21396871 )	Guan B...Zhou X	2011
9	Intracytoplasmic lipid accumulation in apocrine carcinoma of the breast evaluated with adipophilin immunoreactivity: a possible link between apocrine carcinoma and lipid-rich carcinoma. ( 21566511 )	Moritani S...Kato A	2011
10	A case report of lipid-rich carcinoma of the breast including histological characteristics and intrinsic subtype profile. ( 21734882 )	Kimura A...Tsubura A	2011
11	Imprint cytology of primary ethmoidal lipid-rich carcinoma combined with adipophilin immunocytochemistry. ( 20132263 )	Oshiro H...Inayama Y	2010
12	Lipid-rich carcinoma in the mammary gland of a Djungarian hamster (Phodopus sungorus). ( 20224099 )	Yoshimura H...Takahashi K	2010
13	Ethmoidal lipid-rich carcinoma with focal glandular structures. ( 19451474 )	Oshiro H...Inayama Y	2009
14	Lipid-rich carcinoma of breast: a case report with fine needle aspiration cytology. ( 19795489 )	Catalina-Fern?ndez I...S?enz-Santamaria J	2009
15	Lipid-rich carcinoma of the breast: a case report. ( 18411586 )	Shi P...Sun JZ	2008
16	Lipid-rich carcinoma of the breast. A clinicopathological study of 49 cases. ( 18705401 )	Shi P...Sun J	2008
17	Lipid-rich carcinoma of the mammary gland in a cat. ( 15872384 )	Kamstock DA...Ehrhart EJ	2005
18	Metaplastic lipid-rich carcinoma of the breast. ( 9832063 )	Varga Z...Caduff R	1998
19	Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast. ( 2845641 )	Wrba F...Holzner JH	1988
20	Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examples. ( 4815583 )	Ramos CV...Taylor HB	1974

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Genes for Lipid-Rich Carcinoma

Genes related to Lipid-Rich Carcinoma (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PLIN2	Perilipin 2	Protein Coding	21.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	21.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	KRT5	Keratin 5	Protein Coding	14.97	DISEASES inferred ¹⁵
4	KRT14	Keratin 14	Protein Coding	14.8	DISEASES inferred ¹⁵
5	PGR	Progesterone Receptor	Protein Coding	14.46	DISEASES inferred ¹⁵
6	MFGE8	Milk Fat Globule-EGF Factor 8 Protein	Protein Coding	14.36	DISEASES inferred ¹⁵
7	PRLR	Prolactin Receptor	Protein Coding	14.28	DISEASES inferred ¹⁵
8	ESR1	Estrogen Receptor 1	Protein Coding	14.21	DISEASES inferred ¹⁵
9	CDH1	Cadherin 1	Protein Coding	13.32	DISEASES inferred ¹⁵
10	TP53	Tumor Protein P53	Protein Coding	13.09	DISEASES inferred ¹⁵
11	SERPINA1	Serpin Family A Member 1	Protein Coding	13.05	DISEASES inferred ¹⁵
12	EGFR	Epidermal Growth Factor Receptor	Protein Coding	13.05	DISEASES inferred ¹⁵
13	LALBA	Lactalbumin Alpha	Protein Coding	5.61	DISEASES inferred ¹⁵
14	PIP	Prolactin Induced Protein	Protein Coding	5.07	DISEASES inferred ¹⁵
15	CSN2	Casein Beta	Protein Coding	4.7	DISEASES inferred ¹⁵
16	ITLN1	Intelectin 1	Protein Coding	4.31	DISEASES inferred ¹⁵
17	S100A4	S100 Calcium Binding Protein A4	Protein Coding	3.84	DISEASES inferred ¹⁵

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Variations for Lipid-Rich Carcinoma

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Expression for Lipid-Rich Carcinoma

Search GEO for disease gene expression data for Lipid-Rich Carcinoma.

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Pathways for Lipid-Rich Carcinoma

Pathways related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁸	12.66	CDH1 EGFR ERBB2 ESR1 TP53
2	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.47	CDH1 EGFR ERBB2 ESR1 TP53
3	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.4	CDH1 EGFR ERBB2 ESR1 PGR TP53
4	Development EGFR signaling pathway ²³ Show member pathways Development ERBB-family signaling ²³ EGF Pathway ⁶⁵ EGFR Signaling Pathway ⁶⁸ ErbB receptor signaling network ¹	12.35	CDH1 EGFR ERBB2 TP53
5	Prolactin Signaling Pathway ¹ ³⁸ Show member pathways Development Prolactin receptor signaling ²³ Leptin signaling pathway ¹	12.3	CSN2 ERBB2 ESR1 PRLR
6	Proteoglycans in cancer ³⁸	12.06	EGFR ERBB2 ESR1 TP53
7	Integrated Breast Cancer Pathway ¹	11.89	CDH1 EGFR ESR1 TP53
8	MAPK Pathway ⁷³ Show member pathways Toll-like Receptor Pathway ⁷³	11.85	EGFR ERBB2 TP53
9	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁷ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁷ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁷ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁷ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁷ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁷ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁷	11.7	EGFR ERBB2 ESR1
10	Adherens junction ³⁸	11.56	CDH1 EGFR ERBB2
11	Transcription Ligand-dependent activation of the ESR1/SP pathway ²³ Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²³	11.53	EGFR ESR1 PRLR
12	Central carbon metabolism in cancer ³⁸	11.48	EGFR ERBB2 TP53
13	Glucocorticoid receptor regulatory network ¹	11.37	CSN2 KRT14 KRT5 TP53
14	Signaling events mediated by PTP1B ¹	11.31	CSN2 EGFR PRLR
15	Signaling by ERBB4 ⁶⁷ Show member pathways Downregulation of ERBB4 signaling ⁶⁷ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁷	11.13	CSN2 EGFR ERBB2 ESR1 PGR PRLR
16	Bladder cancer ¹ ³⁸	11.12	CDH1 EGFR ERBB2 TP53
17	a6b1 and a6b4 Integrin signaling ¹	11.04	CDH1 EGFR ERBB2
18	Extracellular vesicle-mediated signaling in recipient cells ¹	10.97	EGFR ERBB2 MFGE8
19	E-cadherin signaling in keratinocytes ¹	10.86	CDH1 EGFR

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GO Terms for Lipid-Rich Carcinoma

Cellular components related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.76	CDH1 ITLN1 KRT14 KRT5 MFGE8 PIP
2	extracellular region	GO:0005576	9.36	CDH1 CSN2 EGFR ITLN1 LALBA MFGE8
3	receptor complex	GO:0043235	9.26	EGFR ERBB2 ITLN1 PRLR

Biological processes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:0008544	9.5	EGFR KRT14 KRT5
2	hemidesmosome assembly	GO:0031581	9.26	KRT14 KRT5
3	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.16	ESR1 TP53
4	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	8.96	EGFR TP53
5	negative regulation of ERBB signaling pathway	GO:1901185	8.62	EGFR ERBB2

Molecular functions related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium ion binding	GO:0005509	9.65	CDH1 CSN2 ITLN1 LALBA S100A4
2	protein phosphatase binding	GO:0019903	9.33	EGFR ERBB2 TP53
3	identical protein binding	GO:0042802	9.28	CDH1 EGFR ERBB2 ESR1 ITLN1 PGR
4	nitric-oxide synthase regulator activity	GO:0030235	8.96	EGFR ESR1

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Sources for Lipid-Rich Carcinoma

¹ BioSystems

² BitterDB

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²¹ GeneAnalytics

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²⁵ GeneReviews

²⁶ Genetics Home Reference

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²⁹ GO

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³⁵ ICD10 via Orphanet

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³⁷ IUPHAR

³⁸ KEGG

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⁴⁰ LncRNADisease

⁴¹ LOVD

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⁵⁶ Novoseek

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⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

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⁶² PharmGKB

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⁶⁹ SNOMED-CT

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⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

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⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia