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MCID: LPD003
MIFTS: 32

Lipid-Rich Carcinoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Lipid-Rich Carcinoma

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MalaCards integrated aliases for Lipid-Rich Carcinoma:

Name: Lipid-Rich Carcinoma 12 15 72

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5658
NCIt 50 C4152
SNOMED-CT 68 3839000
UMLS 72 C0334318
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Summaries for Lipid-Rich Carcinoma

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Disease Ontology : 12 A breast carcinoma characterized by the presence of malignant epithelial cells with clear cytoplasm which contains neutral lipids.

MalaCards based summary : Lipid-Rich Carcinoma is related to glycogen-rich clear cell breast carcinoma and apocrine adenocarcinoma. An important gene associated with Lipid-Rich Carcinoma is PLIN2 (Perilipin 2), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include breast and thyroid, and related phenotypes are endocrine/exocrine gland and cellular

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Related Diseases for Lipid-Rich Carcinoma

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Diseases related to Lipid-Rich Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 glycogen-rich clear cell breast carcinoma 30.6 TP53 PGR ESR1
2 apocrine adenocarcinoma 30.4 PGR KRT5 ESR1 ERBB2
3 breast adenocarcinoma 30.1 TP53 ESR1 ERBB2 EGFR
4 in situ carcinoma 28.7 TP53 PGR KRT5 KRT14 ESR1 ERBB2
5 ductal carcinoma in situ 28.7 TP53 PGR KRT5 KRT14 ESR1 ERBB2
6 breast cancer 26.1 TP53 S100A4 PRLR PIP PGR KRT5
7 lipid-rich breast carcinoma 11.8
8 breast apocrine carcinoma 10.8 PGR ERBB2
9 scirrhous adenocarcinoma 10.8 PGR ERBB2
10 bartholin's gland adenoma 10.7 PGR ESR1
11 vestibular gland benign neoplasm 10.7 PGR ESR1
12 lung leiomyoma 10.7 PGR ESR1
13 vulvar syringoma 10.7 PGR ESR1
14 intracystic papillary adenoma 10.7 PGR ERBB2
15 vulvar leiomyoma 10.7 PGR ESR1
16 trigonitis 10.7 PGR ESR1
17 endometrium carcinoma in situ 10.7 TP53 PGR
18 vulvar benign neoplasm 10.7 PGR ESR1
19 lichen planopilaris 10.7 KRT5 KRT14
20 comedo carcinoma 10.7 ESR1 ERBB2
21 epidermolysis bullosa simplex, autosomal recessive 1 10.7 KRT5 KRT14
22 gastric papillary adenocarcinoma 10.6 TP53 ERBB2
23 breast intraductal proliferative lesion 10.6 ERBB2 EGFR
24 bartholin's gland benign neoplasm 10.6 PGR ESR1
25 malignant spiradenoma 10.6 TP53 KRT5
26 esophageal adenosquamous carcinoma 10.6 KRT5 CDH1
27 large cell acanthoma 10.6 KRT5 KRT14
28 breast metaplastic carcinoma 10.6 PGR KRT5 ERBB2
29 rapidly involuting congenital hemangioma 10.6
30 glassy cell carcinoma of the cervix 10.6 PGR ESR1 ERBB2
31 keratinizing squamous cell carcinoma 10.6 TP53 KRT5
32 pleomorphic adenoma carcinoma 10.6 TP53 ERBB2
33 breast medullary carcinoma 10.6 PGR ESR1 ERBB2
34 progesterone-receptor positive breast cancer 10.6 PGR ESR1 ERBB2
35 breast adenoid cystic carcinoma 10.6 PGR ESR1 ERBB2
36 sweat gland disease 10.6 PGR KRT5 KRT14
37 apocrine sweat gland neoplasm 10.6 MFGE8 KRT5 KRT14
38 breast neuroendocrine neoplasm 10.6 PIP ERBB2
39 predominantly cortical thymoma 10.6 PGR KRT14 ESR1
40 breast malignant phyllodes tumor 10.5 TP53 PGR
41 postmenopausal atrophic vaginitis 10.5 PRLR ESR1
42 carcinosarcoma 10.5 TP53 PGR ERBB2
43 brain ependymoma 10.5 TP53 EGFR
44 estrogen-receptor negative breast cancer 10.5 PGR ESR1 ERBB2
45 cribriform carcinoma 10.5 PGR ESR1
46 cerebral convexity meningioma 10.5 TP53 CDH1
47 fibroepithelial basal cell carcinoma 10.5 TP53 KRT14
48 non-proliferative fibrocystic change of the breast 10.5 TP53 ERBB2
49 epithelial-myoepithelial carcinoma 10.5 TP53 PLIN2 KRT14
50 endometrial squamous cell carcinoma 10.5 PGR ESR1

Graphical network of the top 20 diseases related to Lipid-Rich Carcinoma:



Diseases related to Lipid-Rich Carcinoma
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Symptoms & Phenotypes for Lipid-Rich Carcinoma

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MGI Mouse Phenotypes related to Lipid-Rich Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.22 CDH1 CSN2 EGFR ERBB2 ESR1 KRT14
2 cellular MP:0005384 10.2 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
3 integument MP:0010771 10.13 CDH1 CSN2 EGFR ERBB2 ESR1 KRT14
4 immune system MP:0005387 10.07 CDH1 EGFR ESR1 KRT14 MFGE8 PGR
5 digestive/alimentary MP:0005381 10.03 CDH1 EGFR ERBB2 ESR1 KRT14 KRT5
6 adipose tissue MP:0005375 9.95 EGFR ESR1 KRT14 PLIN2 PRLR TP53
7 neoplasm MP:0002006 9.85 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
8 limbs/digits/tail MP:0005371 9.8 EGFR ERBB2 ESR1 KRT5 PGR PRLR
9 normal MP:0002873 9.61 CDH1 EGFR ERBB2 ESR1 ITLN1 LALBA
10 reproductive system MP:0005389 9.36 CDH1 EGFR ERBB2 ESR1 KRT14 MFGE8
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Drugs & Therapeutics for Lipid-Rich Carcinoma

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Search Clinical Trials , NIH Clinical Center for Lipid-Rich Carcinoma

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Genetic Tests for Lipid-Rich Carcinoma

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Anatomical Context for Lipid-Rich Carcinoma

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MalaCards organs/tissues related to Lipid-Rich Carcinoma:

41
Breast, Thyroid
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Publications for Lipid-Rich Carcinoma

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Articles related to Lipid-Rich Carcinoma:

(show all 35)
# Title Authors PMID Year
1
Clinicopathological characteristics of breast sebaceous adenocarcinoma. 38
30509049 2018
2
Lipid-Rich Carcinoma of the Breast With Unusual Clinical and Histopathological Features. 38
26920701 2016
3
Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review. 38
27051299 2016
4
Characterization of Spontaneous Mammary Tumors in Domestic Djungarian Hamsters (Phodopus sungorus). 38
25967136 2015
5
Sebaceous carcinoma of the breast: report of four cases and review of the literature. 38
26247527 2015
6
Lipid-rich carcinoma of the breast: A report of two cases and a literature review. 38
25789031 2015
7
Lipid-rich carcinoma of male breast in Chinese: a case report and literature review. 38
26064365 2015
8
Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog. 38
22261147 2012
9
Intraductal lipid-rich carcinoma of the breast with a component of glycogen-rich carcinoma. 38
22493642 2012
10
Unusual occurrence of rare lipid-rich carcinoma and conventional invasive ductal carcinoma in the one breast: case report. 38
23050179 2012
11
Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases. 38
21396871 2011
12
Intracytoplasmic lipid accumulation in apocrine carcinoma of the breast evaluated with adipophilin immunoreactivity: a possible link between apocrine carcinoma and lipid-rich carcinoma. 38
21566511 2011
13
A case report of lipid-rich carcinoma of the breast including histological characteristics and intrinsic subtype profile. 38
21734882 2011
14
Imprint cytology of primary ethmoidal lipid-rich carcinoma combined with adipophilin immunocytochemistry. 38
20132263 2010
15
Lipid-rich carcinoma in the mammary gland of a Djungarian hamster (Phodopus sungorus). 38
20224099 2010
16
Lipid-rich histology in a basal-type immuno-profile breast carcinoma: a clinicopathological histochemical and immunohistochemical analysis of a case. 38
21139920 2009
17
Lipid-rich carcinoma of breast: a case report with fine needle aspiration cytology. 38
19795489 2009
18
Ethmoidal lipid-rich carcinoma with focal glandular structures. 38
19451474 2009
19
Xanthogranulomatous mastitis: clinicopathology and pathological implications. 38
19351366 2009
20
Lipid-rich carcinoma of the breast. A clinicopathological study of 49 cases. 38
18705401 2008
21
Lipid-rich carcinoma of the breast: a case report. 38
18411586 2008
22
Cytomorphology of rare malignant tumors of the breast. 38
16308090 2005
23
Lipid-rich carcinoma of the mammary gland in a cat. 38
15872384 2005
24
E-cadherin immunohistochemical analysis of histiocytoid carcinoma of the breast. 38
12089723 2002
25
Metaplastic lipid-rich carcinoma of the breast. 38
9832063 1998
26
Lipid-Secreting Carcinoma of the Breast: A Case Report and Review of the Literature. 38
11091643 1998
27
The problematic interpretation of foamy cells in breast fine needle aspirates. A report of two cases. 38
9100799 1997
28
Lipid secreting breast carcinoma in childhood: a case report. 38
8466877 1993
29
Fine-needle aspiration of an apocrine breast carcinoma with multivacuolated, lipid-rich, giant cells. 38
3378488 1988
30
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast. 38
2845641 1988
31
Breast cancer, chronic lymphocytic leukaemia and mucormycosis. 38
2831624 1987
32
Histiocytoid carcinoma: a variant of breast cancer. 38
2425190 1986
33
[Lipid-rich carcinoma of the breast--a case report]. 38
6525953 1984
34
Lipid-rich cell adenoma of the thyroid gland. Report of a peculiar thyroid tumour. 38
6433543 1984
35
Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examples. 38
4815583 1974
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Variations for Lipid-Rich Carcinoma

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Expression for Lipid-Rich Carcinoma

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Search GEO for disease gene expression data for Lipid-Rich Carcinoma.
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Pathways for Lipid-Rich Carcinoma

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Pathways related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 37
12.66 TP53 ESR1 ERBB2 EGFR CDH1
2
Glioma 37
Show member pathways
 12.49 TP53 ESR1 ERBB2 EGFR CDH1
3
Gastric cancer 37
Show member pathways
 12.4 TP53 PGR ESR1 ERBB2 EGFR CDH1
4
Prolactin Signaling Pathway 1 37
Show member pathways
 12.31 PRLR ESR1 ERBB2 CSN2
5
Proteoglycans in cancer 37
12.07 TP53 ESR1 ERBB2 EGFR
6
Integrated Breast Cancer Pathway 1
11.89 TP53 ESR1 EGFR CDH1
7
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.78 TCHP KRT5 KRT14
8
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 11.69 ESR1 ERBB2 EGFR
9
Adherens junction 37
11.55 ERBB2 EGFR CDH1
10
Transcription Ligand-dependent activation of the ESR1/SP pathway 22
Show member pathways
 11.53 PRLR ESR1 EGFR
11
Central carbon metabolism in cancer 37
11.49 TP53 ERBB2 EGFR
12
Glucocorticoid receptor regulatory network 1
11.37 TP53 KRT5 KRT14 CSN2
13
Signaling events mediated by PTP1B 1
11.31 PRLR EGFR CSN2
14
Signaling by ERBB4 66
Show member pathways
 11.13 PRLR PGR ESR1 ERBB2 EGFR CSN2
15
Bladder cancer 37 1
11.12 TP53 ERBB2 EGFR CDH1
16
a6b1 and a6b4 Integrin signaling 1
11.04 ERBB2 EGFR CDH1
17
Extracellular vesicle-mediated signaling in recipient cells 1
10.97 MFGE8 ERBB2 EGFR
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GO Terms for Lipid-Rich Carcinoma

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Cellular components related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 SERPINA1 S100A4 PIP MFGE8 KRT5 KRT14
2 extracellular region GO:0005576 9.36 SERPINA1 S100A4 PRLR PLIN2 PIP MFGE8
3 keratin filament GO:0045095 9.33 TCHP KRT5 KRT14
4 receptor complex GO:0043235 9.26 PRLR ITLN1 ERBB2 EGFR

Biological processes related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.5 KRT5 KRT14 EGFR
2 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
3 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 TP53 ESR1
4 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.96 TP53 EGFR
5 negative regulation of ERBB signaling pathway GO:1901185 8.62 ERBB2 EGFR

Molecular functions related to Lipid-Rich Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 9.33 TP53 ERBB2 EGFR
2 identical protein binding GO:0042802 9.28 TP53 SERPINA1 S100A4 PGR ITLN1 ESR1
3 nitric-oxide synthase regulator activity GO:0030235 8.96 ESR1 EGFR
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Sources for Lipid-Rich Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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