Lipoblastoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ A rare soft tissue tumor characterized by a lobulated, localized (lipoblastoma) or diffuse (lipoblastomatosis) lesion resembling fetal adipose tissue, composed of mature and immature adipocytes. It is most commonly found during the first years of life and presents as a slowly growing, well circumscribed mass, which may compress adjacent structures, depending on the location. Malignant transformation or metastasis does not occur, while recurrences are described especially in lipoblastomatosis.

MalaCards based summary: Lipoblastoma is related to liposarcoma and lipomatosis, multiple. An important gene associated with Lipoblastoma is PLAG1 (PLAG1 Zinc Finger), and among its related pathways/superpathways is PI3K-Akt signaling pathway. Affiliated tissues include salivary gland, spinal cord and testes.

Orphanet: ⁵⁸ A rare soft tissue tumor characterized by a lobulated, localized (lipoblastoma) or diffuse (lipoblastomatosis) lesion resembling fetal adipose tissue, composed of mature and immature adipocytes. It is most commonly found during the first years of life and presents as a slowly growing, well circumscribed mass, which may compress adjacent structures, depending on the location. Malignant transformation or metastasis does not occur, while recurrences are described especially in lipoblastomatosis.

Wikipedia: ⁷⁵ Lipoblastoma is a type of rare, subcutaneous, benign, fatty tumor, found in infants, and children, more... more...

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Related Diseases for Lipoblastoma

Diseases related to Lipoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)

#	Related Disease	Score
1	liposarcoma	10.7
2	lipomatosis, multiple	10.6
3	myxoid liposarcoma	10.5
4	rare tumor	10.5
5	mesenchymal cell neoplasm	10.5
6	pleomorphic adenoma	10.2
7	well-differentiated liposarcoma	10.2
8	short stature, onychodysplasia, facial dysmorphism, and hypotrichosis	10.1
9	connective tissue benign neoplasm	10.1
10	congenital hemidysplasia with ichthyosiform erythroderma and limb defects	10.0
11	spindle cell lipoma	10.0
12	hemangioma	10.0
13	children's interstitial lung disease	10.0
14	rare soft tissue tumor	10.0
15	volvulus of midgut	10.0
16	fibroma	10.0
17	blastoma	10.0
18	respiratory failure	10.0
19	horner's syndrome	10.0
20	lymphangioma	10.0
21	cystic lymphangioma	10.0
22	mediastinal cancer	10.0
23	cellular myxoid liposarcoma	10.0
24	rare lymphatic malformation	10.0
25	cleft palate, isolated	9.8
26	cone-rod dystrophy 2	9.8
27	glomuvenous malformations	9.8
28	intussusception	9.8
29	keloid formation	9.8
30	leiomyoma, uterine	9.8
31	macrodactyly	9.8
32	nevus, epidermal	9.8
33	pelvic organ prolapse	9.8
34	proteus syndrome	9.8
35	retinoblastoma	9.8
36	strabismus	9.8
37	sturge-weber syndrome	9.8
38	testicular torsion	9.8
39	wilms tumor 1	9.8
40	anus, imperforate	9.8
41	hydrocephalus, congenital, 1	9.8
42	alopecia, congenital	9.8
43	granulomatous disease, chronic, x-linked	9.8
44	fanconi anemia, complementation group e	9.8
45	wilms tumor 5	9.8
46	dravet syndrome	9.8
47	osteofibrous dysplasia	9.8
48	leptin deficiency or dysfunction	9.8
49	inguinal hernia	9.8
50	myelomeningocele	9.8

Graphical network of the top 20 diseases related to Lipoblastoma:

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Symptoms & Phenotypes for Lipoblastoma

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Drugs & Therapeutics for Lipoblastoma

Search Clinical Trials, NIH Clinical Center for Lipoblastoma

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Genetic Tests for Lipoblastoma

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Anatomical Context for Lipoblastoma

Organs/tissues related to Lipoblastoma:

MalaCards : Salivary Gland, Spinal Cord, Testes, Kidney, Breast, Tongue, Bone

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Publications for Lipoblastoma

Articles related to Lipoblastoma:

(show top 50) (show all 451)

#	Title	Authors	PMID	Year
1	Diagnosis and treatment of benign adipocytic tumors in children. ⁶²	Perez Daza LD...Quintero Canasto EM	36264345	2022
2	Fatal course of a benign mediastinal lipoblastoma in a 20-year-old woman. ⁶²	Ganzert C...Schreiber J	36274379	2022
3	Multimodality imaging of a mediastinal lipoblastoma: A case report. ⁶²	Wu A...Lv Q	35778244	2022
4	Lipoblastoma of the extremities. ⁶²	Rajput S...Moran SL	36041974	2022
5	Retroperitoneal Lipoblastoma With Cord Compression in an Adult Patient: A Case Report. ⁶²	Alghanmi HA...Saba F	36168653	2022
6	Pediatric fibromyxoid tumor with PLAG1 fusion: An emerging entity with a novel intracranial location. ⁶²	Santisukwongchote S...Teerapakpinyo C	35723650	2022
7	Just an innocent murmur? Large left-ventricular lipoblastoma in an asymptomatic girl. ⁶²	Geiger J...Knirsch W	36045646	2022
8	Metastatic lipoblastoma-like tumour. ⁶²	Chia MRH...Windsor M	35775445	2022
9	Intrascrotal Lipoblastoma: A Rare Cause of Paratesticular Mass in a Pediatric Patient. ⁶²	Fischer KM...Mittal S	35533768	2022
10	A Cheek Mass in a 5-Year-Old Child. ⁶²	Abijay C...Liu C	32998514	2022
11	Lipoblastoma of scalp in a 4-month-old patient: an extremely rare case report and review of the literature. ⁶²	Demir F...Erol FS	34368893	2022
12	[Lipoblastoma-like tumor of the vulva: A case report and review of the literature]. ⁶²	Vasquez-Dongo C...Romagosa C	35483770	2022
13	Imaging features of Lipoblastoma. ⁶²	Ambusaidi FM...Al-Shamsi RM	35573075	2022
14	When is a lipoma not a lipoma? Case report presenting a lipoblastoma-like tumor of the gluteal cleft in an older gentleman with literature review. ⁶²	Yergin CG...Thomas RM	35245849	2022
15	PLAG1 Immunohistochemical Staining Is a Surrogate Marker for PLAG1 Fusions in Lipoblastomas. ⁶²	Warren M...Pawel B	34601996	2022
16	Giant Perineal Plexiform Neurofibroma in an 8-Year-Old African Male. ⁶²	Arredondo Montero J...Bardaji Pascual C	35234555	2022
17	Paediatric thoracic wall lipoblastoma in a 7-year old: a rare tumour of childhood. ⁶²	Prasad G...Bajpai M	35131775	2022
18	Pelvic Lipoblastoma with Extension into Ischiorectal Fossa and Abdominal Lipoblastoma - Complete Excision by Laparoscopy in Children - A Report of Two Cases. ⁶²	Lingegowda AP...Chandrayya R	35261522	2022
19	New PLAG1-fusion transcripts in the spectrum of pediatric fibrotic, lipofibrotic, and mature lipomatous tumors. ⁶²	Theis B...Katenkamp K	36381419	2022
20	Shoulder Lipoblastoma in a 2-Year-Old Boy Case Report and Literature Review. ⁶²	Al-Tammar AA...Khaja A	35415147	2021
21	X-linked Chronic Granulomatous Disease Presenting with Mediastinal Lipoblastoma and Adjacent Pneumonia. ⁶²	Bigley TM...Kitcharoensakkul M	34462840	2021
22	Large intrathoracic lipoblastoma. ⁶²	Safavi M...Ashjaei B	34409876	2021
23	Single-nucleotide variant of PIK3CA H1047R gene assay by CRISPR/Cas12a combined with rolling circle amplification. ⁶²	Cao G...Hou C	34602188	2021
24	The histological and molecular spectrum of lipoblastoma: A case series with identification of three novel gene fusions by targeted RNA-sequencing. ⁶²	Gerhard-Hartmann E...Maurus K	34455363	2021
25	Diagnosis and management of oral cavity lipoblastoma and lipoblastomatosis in an 8-month-old boy. ⁶²	Matous AL...Chen EY	34484749	2021
26	Imaging of head and neck lipoblastoma: case report and systematic review. ⁶²	Lomoro P...Gorone MSP	32141045	2021
27	Lipoblastoma: Diagnosis and surgical considerations. ⁶²	Spataru RI...?erban D	34257716	2021
28	Pediatric lipoblastoma with a novel EEF1A1-PLAG1 fusion. ⁶²	Giovannoni I...Alaggio R	33686712	2021
29	Cardiac lipoblastoma of the pulmonary valve: A rare tumor in an unusual location. ⁶²	Feng T...Song B	33896050	2021
30	Head and neck lipoblastomas: Report of 3 cases and review of the literature. ⁶²	Merzouqi B...Mahtar M	34139421	2021
31	Scrotal Lipoblastoma with Radiological and Histological Correlation. ⁶²	Rousslang LK...Wood JR	34790320	2021
32	Lipoblastoma-like tumor of the spermatic cord: case report and review of the literature. ⁶²	Gambarotti M...Dei Tos AP	32617677	2021
33	A large retroperitoneal lipoblastoma as an incidental finding: a case report. ⁶²	Gerhard-Hartmann E...Ernestus K	33814013	2021
34	Pediatric fibromyxoid soft tissue tumor with PLAG1 fusion: A novel entity? ⁶²	Chung CT...Thorner PS	33300192	2021
35	Lipoblastoma as a cause of secondary omental torsion in children: report of the first case. ⁶²	Boscarelli A...Schleef J	33959253	2021
36	Lipoblastoma: computed tomographic and magnetic resonance imaging features correlate with tumor behavior and pathology. ⁶²	Degnan AJ...Murphey MD	33151344	2021
37	Lipoblastomas and liposarcomas in paediatric patients: A case series. ⁶²	McRae JJLH...Khan FA	33730887	2021
38	Novel ZEB2-PLAG1 fusion gene identified by RNA sequencing in a case of lipoblastoma. ⁶²	Krskova L...Vicha A	32918527	2021
39	Lipoblastomas presenting in older children and adults: analysis of 22 cases with identification of novel PLAG1 fusion partners. ⁶²	Fritchie K...Bahrami A	33097826	2021
40	Dedifferentiated chondrsarcoma: a clinicopathologic analysis of 25 cases. ⁶²	Cao L...Gao BL	33588810	2021
41	Lipoblastoma phenotype contains a somatic PIK3CA mutation. ⁶²	Sudduth CL...Greene AK	33034408	2021
42	Preoperative 3D reconstruction images for paediatric tumours: Advantages and drawbacks. ⁶²	Irtan S...Audry G	32827349	2021
43	Congenital tongue base lipoblastoma causing neonatal airway compromise. ⁶²	Wan MH...Abu Bakar MZ	33462056	2021
44	Case report: Infant with a Fast-growing Soft Tissue Tumor on the Thumb, Revealing a PLAG1-positive Connatal Lipoblastoma. ⁶²	Deeg S...Svoboda D	32937669	2020
45	New molecular insights into the pathogenesis of lipoblastomas: clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases. ⁶²	Lopez-Nunez O...Picarsic J	32692992	2020
46	Pearls and Pitfalls in the Imaging of Soft-Tissue Masses in Children. ⁶²	Navarro OM	32980096	2020
47	Benign mesenteric lipomatous tumor in a child: a case report and literature review. ⁶²	Hashizume N...Yagi M	32997268	2020
48	[Clinical analysis of maxillofacial adipocytic neoplasia in children]. ⁶²	Zheng YY...Li XY	32668879	2020
49	Mediastinal lipoblastoma in paediatrics. ⁶²	Santos C M...Herrera O P	32730544	2020
50	Follow-up outcomes of pediatric patients who underwent surgical resection for lipoblastomas or lipoblastomatosis: a single-institution experience with a systematic review and meta-analysis. ⁶²	Dao D...Ishitani MB	31938836	2020

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Genes for Lipoblastoma

Genes related to Lipoblastoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PLAG1	PLAG1 Zinc Finger	Protein Coding	8.62	GeneCards inferred via : Publications (show sections)
2	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	7.4	GeneCards inferred via : Publications (show sections)
3	RAB2A	RAB2A, Member RAS Oncogene Family	Protein Coding	7.4	GeneCards inferred via : Publications (show sections)

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Variations for Lipoblastoma

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Expression for Lipoblastoma

Search GEO for disease gene expression data for Lipoblastoma.

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Pathways for Lipoblastoma

Pathways related to Lipoblastoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	11.43	RAB2A COL3A1

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GO Terms for Lipoblastoma

Biological processes related to Lipoblastoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organism growth	GO:0035264	8.92	PLAG1 COL3A1

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Sources for Lipoblastoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LPB001 MIFTS: 27	Lipoblastoma Categories: Cancer diseases, Fetal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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