MCID: LPD014
MIFTS: 43

Lipodermatosclerosis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lipodermatosclerosis

MalaCards integrated aliases for Lipodermatosclerosis:

Name: Lipodermatosclerosis 53 73
Hypodermitis Sclerodermaformis 53
Acute Lipodermatosclerosis 53
Sclerosing Panniculitis 53

Classifications:



External Ids:

UMLS 73 C0406500

Summaries for Lipodermatosclerosis

NIH Rare Diseases : 53 Lipodermatosclerosis refers to changes in the skin of the lower legs. It is a form of panniculitis (inflammation of the layer of fat under the skin). Signs and symptoms include pain, hardening of skin, change in skin color (redness), swelling, and a tapering of the legs above the ankles. The exact underlying cause is unknown; however, it appears to be associated with venous insufficiency and/or obesity. Treatment usually includes compression therapy.

MalaCards based summary : Lipodermatosclerosis, also known as hypodermitis sclerodermaformis, is related to varicose veins and venous insufficiency. An important gene associated with Lipodermatosclerosis is ANG (Angiogenin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and PI3K-Akt signaling pathway. The drugs Copper and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and t cells, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Lipodermatosclerosis (also known as "chronic panniculitis with lipomembranous changes", "hypodermitis... more...

Related Diseases for Lipodermatosclerosis

Diseases related to Lipodermatosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 varicose veins 31.4 MMP1 TIMP2 VEGFA
2 venous insufficiency 30.3 MMP1 PLAT
3 chronic venous insufficiency 30.0 MMP1 PLAT
4 macrophage activation syndrome 10.2 ANGPT1 ANGPT2
5 lymphedema 10.2
6 chronic myocardial ischemia 10.1 ANGPT1 VEGFA
7 angiokeratoma circumscriptum 10.1 FLT1 VEGFA
8 glomeruloid hemangioma 10.1 FLT1 VEGFA
9 angiodysplasia 10.1 ANGPT2 VEGFA
10 background diabetic retinopathy 10.1 ANGPT2 VEGFA
11 twin-to-twin transfusion syndrome 10.1 ANGPT1 ANGPT2 FLT1
12 skin hemangioma 10.1 FLT1 VEGFA
13 epithelioid hemangioendothelioma 10.1 FLT1 VEGFA
14 tendinopathy 10.1 MMP1 VEGFA
15 kashin-beck disease 10.1 MMP1 VEGFA
16 capillary hemangioma 10.1 FLT1 VEGFA
17 cancer-associated retinopathy 10.1 FLT1 VEGFA
18 panniculitis 10.1
19 macular holes 10.1 ANGPT2 VEGFA
20 odontogenic myxoma 10.1 MMP1 VEGFA
21 pyogenic granuloma 10.0 ANGPT1 ANGPT2 VEGFA
22 epileptic encephalopathy, childhood-onset 10.0 ANGPT1 ANGPT2 VEGFA
23 pelvic organ prolapse 10.0 COL1A1 MMP1
24 placental insufficiency 10.0 ANGPT2 FLT1 VEGFA
25 angiomatous meningioma 10.0 PLAUR VEGFA
26 exudative vitreoretinopathy 1 10.0 ANGPT2 FLT1 VEGFA
27 microvascular complications of diabetes 5 10.0 ANGPT2 FLT1 VEGFA
28 arteries, anomalies of 10.0 FLT1 PLAT VEGFA
29 gastric lymphoma 10.0 PCNA VEGFA
30 conjunctivochalasis 10.0 MMP1 TIMP2
31 acute mountain sickness 9.9 FLT1 VEGFA
32 scleroderma, familial progressive 9.9
33 eosinophilic fasciitis 9.9
34 angiosarcoma 9.9
35 lymphoma 9.9
36 cutaneous t cell lymphoma 9.9
37 post-thrombotic syndrome 9.9
38 dermatitis 9.9
39 cellulitis 9.9
40 connective tissue disease 9.9
41 fasciitis 9.9
42 muscular dystrophy white matter spongiosis 9.9
43 hypoxia 9.9
44 placenta accreta 9.9 ANGPT1 ANGPT2 FLT1 SERPINB2
45 hemangioma 9.9 ANGPT1 ANGPT2 FLT1 VEGFA
46 ovarian cyst 9.9 PLAT SERPINB2 VEGFA
47 juvenile nasopharyngeal angiofibroma 9.9 PCNA VEGFA
48 dupuytren contracture 9.9 TIMP2 VEGFA
49 pulmonary hypertension 9.9
50 rheumatoid arthritis 9.8 ANGPT1 FLT1 MMP1 VEGFA

Graphical network of the top 20 diseases related to Lipodermatosclerosis:



Diseases related to Lipodermatosclerosis

Symptoms & Phenotypes for Lipodermatosclerosis

MGI Mouse Phenotypes related to Lipodermatosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 ANGPT1 ANGPT2 COL1A1 FLT1 PLAT PLAUR
2 growth/size/body region MP:0005378 9.97 ANGPT1 COL1A1 FLT1 PCNA PLAT PLAUR
3 homeostasis/metabolism MP:0005376 9.96 ANGPT1 ANGPT2 COL1A1 FLT1 MMP1 PLAT
4 hematopoietic system MP:0005397 9.92 COL1A1 FLT1 PCNA PLAT PLAUR SERPINB2
5 immune system MP:0005387 9.9 ANGPT1 ANGPT2 COL1A1 FLT1 MMP1 PCNA
6 muscle MP:0005369 9.5 ANGPT1 COL1A1 FLT1 PLAT PLAUR SERPINB2
7 vision/eye MP:0005391 9.1 ANGPT1 ANGPT2 COL1A1 FLT1 PLAT VEGFA

Drugs & Therapeutics for Lipodermatosclerosis

Drugs for Lipodermatosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Copper Approved, Investigational Not Applicable 7440-50-8 27099
2
Warfarin Approved Not Applicable 81-81-2 6691 54678486
3
Rivaroxaban Approved Not Applicable 366789-02-8
4
Serine Approved, Nutraceutical Not Applicable 56-45-1 5951
5 Anesthetics, Local Not Applicable
6 Anesthetics, General Not Applicable
7 Anesthetics Not Applicable
8 Micronutrients Not Applicable
9 Trace Elements Not Applicable
10
protease inhibitors Not Applicable
11 Antithrombin III Not Applicable
12 Factor Xa Inhibitors Not Applicable
13 HIV Protease Inhibitors Not Applicable
14 Antithrombins Not Applicable
15 Anticoagulants Not Applicable
16 Serine Proteinase Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endovenous Laser Therapy (EVLT) for Sapheno-Popliteal Incompetence and Short Saphenous Vein (SSV) Reflux: A RCT Unknown status NCT00841178 Not Applicable
2 A New Method of Surgically Treating Varicose Veins and Venous Ulcers - a Study to Assess Clinical and Economic Value Unknown status NCT00759434 Not Applicable
3 Copper Impact on Venous Insufficiency and Lipodermatosclerosis Completed NCT03283800 Not Applicable
4 Comparison Between Xarelto Versus Warfarin in the Recanalization Rate of Deep Venous Thrombosis in Patients Legs. Recruiting NCT02704598 Not Applicable Rivaroxaban;Warfarin
5 Ecchymosis and Coldness in Patients With Varicose Vein Not yet recruiting NCT03384355

Search NIH Clinical Center for Lipodermatosclerosis

Genetic Tests for Lipodermatosclerosis

Anatomical Context for Lipodermatosclerosis

MalaCards organs/tissues related to Lipodermatosclerosis:

41
Skin, Liver, T Cells, Bone, Placenta

Publications for Lipodermatosclerosis

Articles related to Lipodermatosclerosis:

(show top 50) (show all 73)
# Title Authors Year
1
A case of gemcitabine-related acute lipodermatosclerosis. ( 30041585 )
2018
2
Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomised controlled trial. ( 30149775 )
2018
3
Pseudomembranous changes in the dermis: A novel observation and potential clue for evolving lipodermatosclerosis? ( 28873249 )
2017
4
Venous Treatment of Lipodermatosclerosis to Improve Ambulatory Function. ( 28858931 )
2017
5
Art and Wound Healing: van Gogh Cypresses-like Lipodermatosclerosis. ( 27852882 )
2016
6
The role of radical surgery in the management of CEAP C5/6 and lipodermatosclerosis. ( 27257053 )
2016
7
Reply letter to the editor, regarding the role of radical surgery in the management of CEAP C5/6 and lipodermatosclerosis. ( 27614760 )
2016
8
Cutaneous T-Cell Lymphoma Misdiagnosed as Lipodermatosclerosis. ( 26914225 )
2016
9
Letter regarding the role of radical surgery in the management of CEAP C5/6 and lipodermatosclerosis. ( 27440460 )
2016
10
Lipodermatosclerosis secondary to pemetrexed use. ( 25695225 )
2015
11
Liver enzymes and lipid levels in patients with lipodermatosclerosis and venous ulcers treated with a prototypic anabolic steroid (stanozolol): a prospective, randomized, double-blinded, placebo-controlled trial. ( 25652757 )
2015
12
Skin and Subcutaneous Tissue Strain in Legs with Lymphedema and Lipodermatosclerosis. ( 25746908 )
2015
13
Lipodermatosclerosis: a clinicopathologic correlation. ( 26275890 )
2015
14
Venous eczema and lipodermatosclerosis. ( 24175404 )
2013
15
Lipodermatosclerosis: improvement noted with hydroxychloroquine and pentoxifylline. ( 22583718 )
2012
16
Refractory lipodermatosclerosis treated with intralesional platelet-rich plasma. ( 22000891 )
2011
17
Abundance of plasma cells in a case of lipodermatosclerosis. ( 20361885 )
2010
18
Lipodermatosclerosis: a clinicopathological study of 25 cases. ( 20466175 )
2010
19
Lipodermatosclerosis: a commonly misdiagnosed complication of chronic venous insufficiency. ( 20364242 )
2010
20
Lipodermatosclerosis. ( 20666825 )
2010
21
Skin iron deposition characterises lipodermatosclerosis and leg ulcer. ( 20880725 )
2010
22
Ultrasound therapy for lipodermatosclerosis. ( 19289773 )
2009
23
Inhibition of angiogenesis in lipodermatosclerosis: implication for venous ulcer formation. ( 19787198 )
2009
24
Lipodermatosclerosis. ( 19467373 )
2009
25
Lipodermatosclerosis: a clinicopathologic study of 17 cases and differential diagnosis from erythema nodosum. ( 19278432 )
2009
26
The accurate diagnosis and treatment of lipodermatosclerosis. ( 19543156 )
2009
27
Acute lipodermatosclerosis: an open clinical trial of stanozolol in patients unable to sustain compression therapy. ( 18700104 )
2008
28
Magnetic resonance imaging as a diagnostic tool for extensive lipodermatosclerosis. ( 18280364 )
2008
29
Angiosarcoma in an area of lipodermatosclerosis. ( 18634723 )
2008
30
Lipodermatosclerosis in patients with diffuse connective tissue diseases. ( 16762781 )
2006
31
Lipodermatosclerosis as a form of vascular compromise-associated radiation recall dermatitis: case report and a review of literature. ( 16972957 )
2006
32
Intralesional triamcinolone in the management of lipodermatosclerosis. ( 16781319 )
2006
33
Lipodermatosclerosis: successful treatment with danazol. ( 16191868 )
2005
34
Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis. ( 16096187 )
2005
35
Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis. ( 15727634 )
2005
36
Sarcoidosis mimicking lipodermatosclerosis. ( 16047869 )
2005
37
Acute lipodermatosclerosis in a 15-year-old girl? ( 15245550 )
2004
38
Progressive, painful hardening of the legs. Lipodermatosclerosis. ( 11868312 )
2002
39
Lipodermatosclerosis: review of cases evaluated at Mayo Clinic. ( 11807428 )
2002
40
Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma. ( 11511304 )
2001
41
Gemcitabine-induced acute lipodermatosclerosis-like reaction. ( 11859947 )
2001
42
Morphology of lymphatics in human venous crural ulcers with lipodermatosclerosis. ( 11549123 )
2001
43
The role of the urokinase-type plasminogen activator (uPA) and its receptor (CD87) in lipodermatosclerosis. ( 11401675 )
2001
44
Pericapillary fibrin deposits and skin hypoxia precede the changes of lipodermatosclerosis in limbs at increased risk of developing a venous ulcer. ( 10959062 )
2000
45
Lipodermatosclerosis and compression stockings. ( 10642701 )
2000
46
Treatment of lipodermatosclerosis with oxandrolone in a patient with stanozolol-induced hepatotoxicity. ( 10954677 )
2000
47
Desideratum dermatologicum: eliminating lipodermatosclerosis; the term and the entities. ( 10940110 )
2000
48
Surgical removal of ulcer and lipodermatosclerosis followed by split-skin grafting (shave therapy) yields good long-term results in "non-healing" venous leg ulcers. ( 11028859 )
2000
49
Lipodermatosclerosis - report of three cases and review of the literature. ( 10592414 )
1999
50
Lipodermatosclerosis and the significance of proteolytic remodeling in the pathogenesis of venous ulceration (Review). ( 10202183 )
1999

Variations for Lipodermatosclerosis

Expression for Lipodermatosclerosis

Search GEO for disease gene expression data for Lipodermatosclerosis.

Pathways for Lipodermatosclerosis

Pathways related to Lipodermatosclerosis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 ANGPT1 ANGPT2 MMP1 PLAT PLAUR SERPINB2
2
Show member pathways
12.73 ANGPT1 ANGPT2 COL1A1 FLT1 VEGFA
3
Show member pathways
12.69 PLAT PLAUR SERPINB2 VEGFA
4 12.54 ANGPT1 ANGPT2 FLT1 VEGFA
5
Show member pathways
12.51 ANGPT1 ANGPT2 FLT1 VEGFA
6
Show member pathways
12.03 ANGPT1 ANGPT2 MMP1
7
Show member pathways
12.01 COL1A1 FLT1 VEGFA
8 11.87 PLAT PLAUR SERPINB2
9
Show member pathways
11.82 ANGPT1 ANGPT2 FLT1 TIMP2
10 11.69 COL1A1 PCNA PLAT SERPINB2
11 11.62 ANGPT1 ANGPT2 FLT1 VEGFA
12 11.6 ANGPT2 FLT1 TIMP2
13 11.51 ANGPT1 FLT1 MMP1 VEGFA
14 11.21 MMP1 TIMP2
15 11.18 ANGPT1 ANGPT2 VEGFA
16 11.14 FLT1 VEGFA
17 11.14 MMP1 PLAUR
18 11.01 FLT1 VEGFA
19 10.84 MMP1 VEGFA
20 10.81 COL1A1 MMP1 PLAT PLAUR TIMP2
21 10.79 PLAT VEGFA
22 10.76 ANGPT1 ANGPT2 COL1A1 FLT1 TIMP2
23
Show member pathways
10.73 FLT1 VEGFA
24 10.64 ANGPT1 FLT1 TIMP2 VEGFA
25 10.45 PLAT PLAUR SERPINB2

GO Terms for Lipodermatosclerosis

Cellular components related to Lipodermatosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.62 PLAT PLAUR TIMP2 VEGFA
2 extracellular space GO:0005615 9.61 ANG ANGPT1 ANGPT2 COL1A1 FLT1 PLAT
3 extracellular matrix GO:0031012 9.46 COL1A1 MMP1 TIMP2 VEGFA
4 secretory granule GO:0030141 9.43 COL1A1 PLAT VEGFA
5 extracellular region GO:0005576 9.36 ANG ANGPT1 ANGPT2 COL1A1 FLT1 MMP1

Biological processes related to Lipodermatosclerosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.97 ANG ANGPT1 ANGPT2 FLT1 VEGFA
2 cell differentiation GO:0030154 9.91 ANG ANGPT1 ANGPT2 FLT1 VEGFA
3 negative regulation of apoptotic process GO:0043066 9.8 ANGPT1 FLT1 PLAUR SERPINB2 VEGFA
4 positive regulation of cell migration GO:0030335 9.77 COL1A1 FLT1 VEGFA
5 blood coagulation GO:0007596 9.73 COL1A1 PLAT PLAUR
6 positive regulation of angiogenesis GO:0045766 9.67 ANGPT2 FLT1 VEGFA
7 leukocyte migration GO:0050900 9.67 ANGPT1 ANGPT2 COL1A1 MMP1
8 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 FLT1 VEGFA
9 sprouting angiogenesis GO:0002040 9.57 ANGPT1 VEGFA
10 response to hypoxia GO:0001666 9.56 ANG ANGPT2 PLAT VEGFA
11 blood vessel morphogenesis GO:0048514 9.55 ANGPT2 FLT1
12 negative regulation of proteolysis GO:0045861 9.54 PLAT TIMP2
13 positive regulation of receptor internalization GO:0002092 9.52 ANGPT1 VEGFA
14 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.48 FLT1 VEGFA
15 negative regulation of cell-substrate adhesion GO:0010812 9.46 ANGPT2 COL1A1
16 vascular endothelial growth factor signaling pathway GO:0038084 9.43 FLT1 VEGFA
17 glomerulus vasculature development GO:0072012 9.32 ANGPT1 ANGPT2
18 Tie signaling pathway GO:0048014 9.16 ANGPT1 ANGPT2
19 fibrinolysis GO:0042730 9.13 PLAT PLAUR SERPINB2
20 angiogenesis GO:0001525 9.02 ANG ANGPT1 ANGPT2 FLT1 VEGFA

Molecular functions related to Lipodermatosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 9.13 ANGPT1 ANGPT2 PCNA
2 signaling receptor binding GO:0005102 9.02 ANG ANGPT1 ANGPT2 PLAT PLAUR

Sources for Lipodermatosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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