MCID: LPD014
MIFTS: 42

Lipodermatosclerosis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lipodermatosclerosis

MalaCards integrated aliases for Lipodermatosclerosis:

Name: Lipodermatosclerosis 53 73
Hypodermitis Sclerodermaformis 53
Acute Lipodermatosclerosis 53
Sclerosing Panniculitis 53

Classifications:



External Ids:

UMLS 73 C0406500

Summaries for Lipodermatosclerosis

NIH Rare Diseases : 53 Lipodermatosclerosis refers to changes in the skin of the lower legs. It is a form of panniculitis (inflammation of the layer of fat under the skin). Signs and symptoms include pain, hardening of skin, change in skin color (redness), swelling, and a tapering of the legs above the ankles. The exact underlying cause is unknown; however, it appears to be associated with venous insufficiency and/or obesity. Treatment usually includes compression therapy.

MalaCards based summary : Lipodermatosclerosis, also known as hypodermitis sclerodermaformis, is related to varicose veins and chronic venous insufficiency. An important gene associated with Lipodermatosclerosis is SERPINB2 (Serpin Family B Member 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Warfarin and Rivaroxaban have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Lipodermatosclerosis (also known as \"chronic panniculitis with lipomembranous changes\", \"hypodermitis... more...

Related Diseases for Lipodermatosclerosis

Diseases related to Lipodermatosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 varicose veins 30.8 MMP1 TIMP2 VEGFA
2 chronic venous insufficiency 30.1 MMP1 PLAT
3 venous insufficiency 30.0 MMP1 PLAT
4 conjunctivochalasis 10.5 MMP1 TIMP2
5 preterm premature rupture of the membranes 10.5 MMP1 TIMP2
6 nodular malignant melanoma 10.4 MMP1 TIMP2
7 macrophage activation syndrome 10.0 ANGPT1 ANGPT2
8 pelvic organ prolapse 10.0 COL1A1 MMP1
9 lymphedema 10.0
10 angiomatous meningioma 10.0 PLAUR VEGFA
11 dupuytren contracture 9.9 TIMP2 VEGFA
12 panniculitis 9.9
13 gastric lymphoma 9.9 PCNA VEGFA
14 angiokeratoma circumscriptum 9.9 FLT1 VEGFA
15 glomeruloid hemangioma 9.9 FLT1 VEGFA
16 odontogenic myxoma 9.8 MMP1 VEGFA
17 epithelioid hemangioendothelioma 9.8 FLT1 VEGFA
18 cancer-associated retinopathy 9.8 FLT1 VEGFA
19 acute hemorrhagic leukoencephalitis 9.8 FLT1 VEGFA
20 background diabetic retinopathy 9.8 ANGPT2 VEGFA
21 ovarian cyst 9.8 PLAT SERPINB2 VEGFA
22 cutaneous t cell lymphoma 9.8
23 post-thrombotic syndrome 9.8
24 dermatitis 9.8
25 connective tissue disease 9.8
26 fasciitis 9.8
27 type i 9.8
28 scleroderma, familial progressive 9.8
29 muscular dystrophy white matter spongiosis 9.8
30 hypoxia 9.8
31 eosinophilic fasciitis 9.8
32 skin disease 9.8
33 angiosarcoma 9.8
34 lymphoma 9.8
35 poems syndrome 9.8 ANGPT2 VEGFA
36 peripartum cardiomyopathy 9.7 FLT1 VEGFA
37 chronic myocardial ischemia 9.7 ANGPT1 VEGFA
38 juvenile nasopharyngeal angiofibroma 9.7 PCNA VEGFA
39 adenomyosis 9.6 MMP1 TIMP2 VEGFA
40 macular holes 9.6 ANGPT2 VEGFA
41 microcystic meningioma 9.6 FLT1 TIMP2 VEGFA
42 retinal ischemia 9.6 PCNA VEGFA
43 corneal neovascularization 9.6 FLT1 TIMP2 VEGFA
44 twin-to-twin transfusion syndrome 9.5 ANGPT1 ANGPT2 FLT1
45 vascular cancer 9.3 FLT1 VEGFA
46 placental insufficiency 9.3 ANGPT2 FLT1 VEGFA
47 microvascular complications of diabetes 1 9.3 ANGPT2 FLT1 VEGFA
48 retinal vascular disease 9.3 ANGPT2 FLT1 VEGFA
49 exudative vitreoretinopathy 1 9.3 ANGPT2 FLT1 VEGFA
50 microvascular complications of diabetes 5 9.3 ANGPT2 FLT1 VEGFA

Graphical network of the top 20 diseases related to Lipodermatosclerosis:



Diseases related to Lipodermatosclerosis

Symptoms & Phenotypes for Lipodermatosclerosis

MGI Mouse Phenotypes related to Lipodermatosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 COL1A1 FLT1 TIMP2 VEGFA ANGPT1 PLAT
2 growth/size/body region MP:0005378 9.97 PLAUR COL1A1 SERPINB2 FLT1 PCNA ANGPT1
3 homeostasis/metabolism MP:0005376 9.96 SERPINB2 FLT1 TIMP2 VEGFA MMP1 ANGPT1
4 hematopoietic system MP:0005397 9.92 COL1A1 SERPINB2 FLT1 TIMP2 VEGFA PCNA
5 immune system MP:0005387 9.9 SERPINB2 FLT1 TIMP2 VEGFA MMP1 PCNA
6 muscle MP:0005369 9.5 SERPINB2 FLT1 VEGFA ANGPT1 PLAT PLAUR
7 vision/eye MP:0005391 9.1 COL1A1 FLT1 ANGPT1 PLAT ANGPT2 VEGFA

Drugs & Therapeutics for Lipodermatosclerosis

Drugs for Lipodermatosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Not Applicable 81-81-2 6691 54678486
2
Rivaroxaban Approved Not Applicable 366789-02-8
3
Copper Approved, Investigational Not Applicable 7440-50-8 27099
4
Serine Approved, Nutraceutical Not Applicable 56-45-1 5951
5
protease inhibitors Not Applicable
6 Serine Proteinase Inhibitors Not Applicable
7 HIV Protease Inhibitors Not Applicable
8 Anesthetics Not Applicable
9 Anesthetics, General Not Applicable
10 Anesthetics, Local Not Applicable
11 Anticoagulants Not Applicable
12 Factor Xa Inhibitors Not Applicable
13 Antithrombin III Not Applicable
14 Antithrombins Not Applicable
15 Micronutrients Not Applicable
16 Trace Elements Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endovenous Laser Therapy (EVLT) for Sapheno-Popliteal Incompetence and Short Saphenous Vein (SSV) Reflux: A RCT Unknown status NCT00841178 Not Applicable
2 A New Method of Surgically Treating Varicose Veins and Venous Ulcers - a Study to Assess Clinical and Economic Value Unknown status NCT00759434 Not Applicable
3 Comparison Between Xarelto Versus Warfarin in the Recanalization Rate of Deep Venous Thrombosis in Patients Legs. Unknown status NCT02704598 Not Applicable Rivaroxaban;Warfarin
4 Copper Impact on Venous Insufficiency and Lipodermatosclerosis Completed NCT03283800 Not Applicable
5 Ecchymosis and Coldness in Patients With Varicose Vein Not yet recruiting NCT03384355

Search NIH Clinical Center for Lipodermatosclerosis

Genetic Tests for Lipodermatosclerosis

Anatomical Context for Lipodermatosclerosis

MalaCards organs/tissues related to Lipodermatosclerosis:

41
Skin, T Cells, Liver

Publications for Lipodermatosclerosis

Articles related to Lipodermatosclerosis:

(show top 50) (show all 70)
# Title Authors Year
1
Pseudomembranous changes in the dermis: A novel observation and potential clue for evolving lipodermatosclerosis? ( 28873249 )
2017
2
Venous Treatment of Lipodermatosclerosis to Improve Ambulatory Function. ( 28858931 )
2017
3
Art and Wound Healing: van Gogh Cypresses-like Lipodermatosclerosis. ( 27852882 )
2016
4
The role of radical surgery in the management of CEAP C5/6 and lipodermatosclerosis. ( 27257053 )
2016
5
Reply letter to the editor, regarding the role of radical surgery in the management of CEAP C5/6 and lipodermatosclerosis. ( 27614760 )
2016
6
Cutaneous T-Cell Lymphoma Misdiagnosed as Lipodermatosclerosis. ( 26914225 )
2016
7
Letter regarding the role of radical surgery in the management of CEAP C5/6 and lipodermatosclerosis. ( 27440460 )
2016
8
Lipodermatosclerosis secondary to pemetrexed use. ( 25695225 )
2015
9
Liver enzymes and lipid levels in patients with lipodermatosclerosis and venous ulcers treated with a prototypic anabolic steroid (stanozolol): a prospective, randomized, double-blinded, placebo-controlled trial. ( 25652757 )
2015
10
Skin and Subcutaneous Tissue Strain in Legs with Lymphedema and Lipodermatosclerosis. ( 25746908 )
2015
11
Lipodermatosclerosis: a clinicopathologic correlation. ( 26275890 )
2015
12
Venous eczema and lipodermatosclerosis. ( 24175404 )
2013
13
Lipodermatosclerosis: improvement noted with hydroxychloroquine and pentoxifylline. ( 22583718 )
2012
14
Refractory lipodermatosclerosis treated with intralesional platelet-rich plasma. ( 22000891 )
2011
15
Abundance of plasma cells in a case of lipodermatosclerosis. ( 20361885 )
2010
16
Lipodermatosclerosis: a clinicopathological study of 25 cases. ( 20466175 )
2010
17
Lipodermatosclerosis: a commonly misdiagnosed complication of chronic venous insufficiency. ( 20364242 )
2010
18
Lipodermatosclerosis. ( 20666825 )
2010
19
Skin iron deposition characterises lipodermatosclerosis and leg ulcer. ( 20880725 )
2010
20
Ultrasound therapy for lipodermatosclerosis. ( 19289773 )
2009
21
Inhibition of angiogenesis in lipodermatosclerosis: implication for venous ulcer formation. ( 19787198 )
2009
22
Lipodermatosclerosis. ( 19467373 )
2009
23
Lipodermatosclerosis: a clinicopathologic study of 17 cases and differential diagnosis from erythema nodosum. ( 19278432 )
2009
24
The accurate diagnosis and treatment of lipodermatosclerosis. ( 19543156 )
2009
25
Acute lipodermatosclerosis: an open clinical trial of stanozolol in patients unable to sustain compression therapy. ( 18700104 )
2008
26
Magnetic resonance imaging as a diagnostic tool for extensive lipodermatosclerosis. ( 18280364 )
2008
27
Angiosarcoma in an area of lipodermatosclerosis. ( 18634723 )
2008
28
Lipodermatosclerosis in patients with diffuse connective tissue diseases. ( 16762781 )
2006
29
Lipodermatosclerosis as a form of vascular compromise-associated radiation recall dermatitis: case report and a review of literature. ( 16972957 )
2006
30
Intralesional triamcinolone in the management of lipodermatosclerosis. ( 16781319 )
2006
31
Lipodermatosclerosis: successful treatment with danazol. ( 16191868 )
2005
32
Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis. ( 16096187 )
2005
33
Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis. ( 15727634 )
2005
34
Acute lipodermatosclerosis in a 15-year-old girl? ( 15245550 )
2004
35
Progressive, painful hardening of the legs. Lipodermatosclerosis. ( 11868312 )
2002
36
Lipodermatosclerosis: review of cases evaluated at Mayo Clinic. ( 11807428 )
2002
37
Different pattern of collagen cross-links in two sclerotic skin diseases: lipodermatosclerosis and circumscribed scleroderma. ( 11511304 )
2001
38
Gemcitabine-induced acute lipodermatosclerosis-like reaction. ( 11859947 )
2001
39
Morphology of lymphatics in human venous crural ulcers with lipodermatosclerosis. ( 11549123 )
2001
40
The role of the urokinase-type plasminogen activator (uPA) and its receptor (CD87) in lipodermatosclerosis. ( 11401675 )
2001
41
Pericapillary fibrin deposits and skin hypoxia precede the changes of lipodermatosclerosis in limbs at increased risk of developing a venous ulcer. ( 10959062 )
2000
42
Lipodermatosclerosis and compression stockings. ( 10642701 )
2000
43
Treatment of lipodermatosclerosis with oxandrolone in a patient with stanozolol-induced hepatotoxicity. ( 10954677 )
2000
44
Desideratum dermatologicum: eliminating lipodermatosclerosis; the term and the entities. ( 10940110 )
2000
45
Surgical removal of ulcer and lipodermatosclerosis followed by split-skin grafting (shave therapy) yields good long-term results in "non-healing" venous leg ulcers. ( 11028859 )
2000
46
Lipodermatosclerosis - report of three cases and review of the literature. ( 10592414 )
1999
47
Lipodermatosclerosis and the significance of proteolytic remodeling in the pathogenesis of venous ulceration (Review). ( 10202183 )
1999
48
Acute lipase-induced panniculitis in rats with ligated veins of the hindlimb: a contribution to the role of acute panniculitis as a precursor of lipodermatosclerosis of venous disease. ( 9890369 )
1999
49
Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: implications for venous ulcer formation. ( 9804345 )
1998
50
Lipodermatosclerosis and atrophie blanche. ( 9887734 )
1998

Variations for Lipodermatosclerosis

Expression for Lipodermatosclerosis

Search GEO for disease gene expression data for Lipodermatosclerosis.

Pathways for Lipodermatosclerosis

Pathways related to Lipodermatosclerosis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 ANGPT1 ANGPT2 MMP1 PLAT PLAUR SERPINB2
2
Show member pathways
12.68 PLAT PLAUR SERPINB2 VEGFA
3
Show member pathways
12.68 ANGPT1 ANGPT2 COL1A1 FLT1 VEGFA
4 12.54 ANGPT1 ANGPT2 FLT1 VEGFA
5
Show member pathways
12.5 ANGPT1 ANGPT2 FLT1 VEGFA
6
Show member pathways
12.02 ANGPT1 ANGPT2 MMP1
7
Show member pathways
12.01 COL1A1 FLT1 VEGFA
8 11.86 PLAT PLAUR SERPINB2
9
Show member pathways
11.81 ANGPT1 ANGPT2 FLT1 TIMP2
10 11.69 COL1A1 PCNA PLAT SERPINB2
11 11.62 ANGPT1 ANGPT2 FLT1 VEGFA
12 11.6 ANGPT2 FLT1 TIMP2
13 11.51 ANGPT1 FLT1 MMP1 VEGFA
14 11.21 MMP1 TIMP2
15 11.18 ANGPT1 ANGPT2 VEGFA
16 11.14 FLT1 VEGFA
17 11.13 MMP1 PLAUR
18 10.99 FLT1 VEGFA
19 10.83 MMP1 VEGFA
20 10.81 COL1A1 MMP1 PLAT PLAUR TIMP2
21 10.78 PLAT VEGFA
22
Show member pathways
10.71 FLT1 VEGFA
23 10.64 ANGPT1 FLT1 TIMP2 VEGFA
24 10.45 PLAT PLAUR SERPINB2

GO Terms for Lipodermatosclerosis

Cellular components related to Lipodermatosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.62 PLAT PLAUR TIMP2 VEGFA
2 extracellular space GO:0005615 9.61 ANG ANGPT1 ANGPT2 COL1A1 FLT1 PLAT
3 extracellular matrix GO:0031012 9.46 COL1A1 MMP1 PLAT TIMP2
4 secretory granule GO:0030141 9.43 COL1A1 PLAT VEGFA
5 extracellular region GO:0005576 9.36 ANG ANGPT1 ANGPT2 COL1A1 FLT1 MMP1

Biological processes related to Lipodermatosclerosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.92 ANG ANGPT1 ANGPT2 FLT1 VEGFA
2 negative regulation of apoptotic process GO:0043066 9.8 ANGPT1 FLT1 PLAUR SERPINB2 VEGFA
3 positive regulation of cell migration GO:0030335 9.75 COL1A1 FLT1 VEGFA
4 blood coagulation GO:0007596 9.74 COL1A1 PLAT PLAUR
5 leukocyte migration GO:0050900 9.67 ANGPT1 ANGPT2 COL1A1 MMP1
6 positive regulation of angiogenesis GO:0045766 9.65 ANGPT2 FLT1 VEGFA
7 positive chemotaxis GO:0050918 9.59 ANGPT1 VEGFA
8 ovarian follicle development GO:0001541 9.58 ANG VEGFA
9 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.56 FLT1 VEGFA
10 response to hypoxia GO:0001666 9.56 ANG ANGPT2 PLAT VEGFA
11 sprouting angiogenesis GO:0002040 9.55 ANGPT1 FLT1
12 blood vessel morphogenesis GO:0048514 9.54 ANGPT2 FLT1
13 negative regulation of proteolysis GO:0045861 9.51 PLAT TIMP2
14 positive regulation of receptor internalization GO:0002092 9.49 ANGPT1 VEGFA
15 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.46 FLT1 VEGFA
16 negative regulation of cell-substrate adhesion GO:0010812 9.43 ANGPT2 COL1A1
17 glomerulus vasculature development GO:0072012 9.32 ANGPT1 ANGPT2
18 Tie signaling pathway GO:0048014 9.16 ANGPT1 ANGPT2
19 fibrinolysis GO:0042730 9.13 PLAT PLAUR SERPINB2
20 angiogenesis GO:0001525 9.02 ANG ANGPT1 ANGPT2 FLT1 VEGFA

Molecular functions related to Lipodermatosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 9.13 ANGPT1 ANGPT2 PCNA
2 signaling receptor binding GO:0005102 9.02 ANG ANGPT1 ANGPT2 PLAT PLAUR

Sources for Lipodermatosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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