Lipomatosis, Multiple disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LPM012 MIFTS: 58	Lipomatosis, Multiple Categories: Rare diseases, Skin diseases, Cancer diseases, Genetic diseases, Metabolic diseases
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Aliases & Classifications for Lipomatosis, Multiple

MalaCards integrated aliases for Lipomatosis, Multiple:

Name: Lipomatosis, Multiple ⁵⁷ ²⁹ ⁷³

Lipoma ⁵⁷ ¹² ²⁹ ⁵⁵ ¹⁵ ⁷³

Lipomatosis, Familial Multiple ⁵⁷ ¹²

Familial Multiple Lipomatosis ⁵³ ⁵⁹

Benign Lipomatous Tumor ¹² ⁷³

Multiple Lipomatosis ¹² ⁵³

Lipomatous Neoplasm ¹² ⁷³

Lipomatosis, Familial Multiple; Fml ⁵⁷

Benign Tumor of Adipose Tissue ¹²

Neoplasms, Adipose Tissue ⁴⁴

Tumor of Adipose Tissue ¹²

Lipomatous Tumor ¹²

Lipoma; Lipo ⁵⁷

Lipo ⁵⁷

Fml ⁵⁷

Characteristics:

OMIM:

⁵⁷

Inheritance:
autosomal dominant

HPO:

³²

lipomatosis, multiple:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Genetic diseases Metabolic diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Other metabolic disorders

Lipomatosis, not elsewhere classified

Neoplasms

Benign neoplasms

Benign lipomatous neoplasm

Benign lipomatous neoplasm, unspecified

Orphanet: ⁵⁹

Rare skin diseases

External Ids:

OMIM ⁵⁷ 151900

Disease Ontology ¹² DOID:3315

ICD10 ³³ D17 D17.9

ICD9CM ³⁵ 214 214.9

MeSH ⁴⁴ D008067 D018205

NCIt ⁵⁰ C3192 C4248 C4502

SNOMED-CT ⁶⁸ 115227001 154612003 189018005 more

Orphanet ⁵⁹ ORPHA199276

UMLS via Orphanet ⁷⁴ C3489413

ICD10 via Orphanet ³⁴ E88.2

MedGen ⁴² C3489413

UMLS ⁷³ C0023798 C0206631 C0346118 more

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Summaries for Lipomatosis, Multiple

NIH Rare Diseases : ⁵³ Familial multiple lipomatosis (FML) is a rare condition that is characterized by multiple lipomas on the trunk and extremities. As the name suggests, FML is diagnosed when multiple lipomatosis occurs in more than one family member, often over several generations. The lipomas associated with FML are usually painless, but may impact quality of life as they can be numerous and large. Although the condition appears to be passed down through families in an autosomal dominant manner, the underlying genetic cause is currently unknown. Treatment is based on the signs and symptoms present in each person. Surgical excision may be necessary if the tumors interfere with movement and/or daily life.

MalaCards based summary : Lipomatosis, Multiple, also known as lipoma, is related to atypical lipomatous tumor and skin lipoma. An important gene associated with Lipomatosis, Multiple is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are p53 Signaling and Chromatin Regulation / Acetylation. The drugs Cortisone acetate and Isoproterenol have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and skin, and related phenotypes are macrocephaly and coloboma

Disease Ontology : ¹² A cell type benign neoplasm that is composed of lipocytes.

OMIM : ⁵⁷ Familial multiple lipomatosis is a rare autosomal dominant disorder characterized by numerous encapsulated lipomas on the trunk and extremities (Keskin et al., 2002). (151900)

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Related Diseases for Lipomatosis, Multiple

Diseases in the Lipomatosis family:

Lipomatosis, Multiple

Diseases related to Lipomatosis, Multiple via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)

#	Related Disease	Score	Top Affiliating Genes
1	atypical lipomatous tumor	33.5	CDK4 FUS HMGA2 MDM2
2	skin lipoma	32.5	HMGA2 PTEN
3	pleomorphic lipoma	32.2	CDK4 HMGA2 MDM2
4	lipomatosis	30.8	HMGA2 MEN1 PTEN
5	spindle cell liposarcoma	30.6	CDK4 MDM2
6	well-differentiated liposarcoma	30.4	CDK4 HMGA2 MDM2
7	spindle cell lipoma	30.3	CDK4 DES MDM2
8	liposarcoma	29.2	CDK4 DES FUS HMGA2 MDM2
9	hemihyperplasia-multiple lipomatosis syndrome	12.3
10	lipomatosis, multiple symmetric	12.3
11	neuronal ceroid lipofuscinosis	11.0
12	ring chromosome 7	10.8	CDK4 MDM2
13	ring chromosome 1	10.8	HMGA1 HMGA2
14	undifferentiated embryonal sarcoma of the liver	10.7	CDK4 MDM2
15	infiltrating angiolipoma	10.7	CDK4 MDM2
16	extraosseous osteosarcoma	10.7	CDK4 MDM2
17	inflammatory mfh	10.7	CDK4 MDM2
18	pelvic lipomatosis	10.7	HMGA1 HMGA2
19	bone osteosarcoma	10.7	CDK4 MDM2
20	lipoblastoma	10.7	CDK4 MDM2
21	periosteal chondrosarcoma	10.7	CDK4 MDM2
22	periosteal osteogenic sarcoma	10.6	CDK4 MDM2
23	sclerosing liposarcoma	10.6	FUS MDM2
24	juxtacortical chondroma	10.6	FUS HMGA2
25	small cell sarcoma	10.5	CDK4 MDM2
26	lipoma of colon	10.5	HMGA2 NFIB
27	large intestine lipoma	10.5	HMGA2 NFIB
28	juxtacortical osteosarcoma	10.5	CDK4 MDM2
29	anaplastic ependymoma	10.5	MDM2 PTEN
30	pleomorphic liposarcoma	10.5	DES MDM2
31	congenital heart defects, hamartomas of tongue, and polysyndactyly	10.5	HMGA2 PTEN
32	gliomatosis cerebri	10.4	MDM2 PTEN
33	myxofibrosarcoma	10.4	DES FUS
34	mixed liposarcoma	10.4	CDK4 FUS MDM2
35	connective tissue cancer	10.3	CDK4 FUS MDM2
36	spindle cell sarcoma	10.3	DES MDM2
37	histiocytoma	10.3	CDK4 FUS MDM2
38	mesenchymoma	10.3	DES HMGA2 MDM2
39	acute t cell leukemia	10.3	LPP PTEN
40	grade iii astrocytoma	10.3	CDK4 MDM2 PTEN
41	extraskeletal ewing sarcoma	10.3	DES FUS
42	sarcoma, synovial	10.3	DES HMGA2 MDM2
43	smooth muscle tumor	10.3	DES HMGA2
44	malignant fibrous histiocytoma of bone	10.3	CDK4 DES MDM2
45	ischemic fasciitis	10.3	CDK4 DES MDM2
46	embryonal sarcoma	10.3	CDK4 DES MDM2
47	malignant fibroxanthoma	10.3	CDK4 DES MDM2
48	malignant mesenchymoma	10.3	CDK4 DES MDM2
49	malignant ectomesenchymoma	10.2	DES HMGA1 HMGA2
50	skin melanoma	10.2	CDK4 MDM2 PTEN

Graphical network of the top 20 diseases related to Lipomatosis, Multiple:

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Symptoms & Phenotypes for Lipomatosis, Multiple

Symptoms via clinical synopsis from OMIM:

⁵⁷

Skin:
lipomatosis

Lab:
frequent rearrangements at 12q13 or 12q14

Clinical features from OMIM:

151900

Human phenotypes related to Lipomatosis, Multiple:

⁵⁹ ³² (show all 25)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	macrocephaly ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0000256
2	coloboma ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0000589
3	delayed speech and language development ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0000750
4	insulin resistance ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0000855
5	seizures ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001250
6	overgrowth ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001548
7	hypoplasia of the corpus callosum ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0002079
8	ventriculomegaly ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0002119
9	cerebral calcification ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0002514
10	medulloblastoma ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0002885
11	bowing of the long bones ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0006487
12	hyperlipidemia ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0003077
13	peripheral neuropathy ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0009830
14	functional intestinal obstruction ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0005249
15	accelerated skeletal maturation ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0005616
16	premature eruption of permanent teeth ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0006337
17	lipodystrophy ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0009125
18	increased adipose tissue ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0009126
19	chorioretinitis ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0012424
20	arachnoid cyst ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0100702
21	abnormality of the tricuspid valve ⁵⁹		Occasional (29-5%)
22	keratocystic odontogenic tumor ⁵⁹		Occasional (29-5%)
23	multiple lipomas ³²			HP:0001012
24	abnormal tricuspid valve morphology ³²	occasional (7.5%)		HP:0001702
25	odontogenic keratocysts of the jaw ³²	occasional (7.5%)		HP:0010603

GenomeRNAi Phenotypes related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

²⁶ (show all 24)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.77	NFIB
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.77	FUS MEN1 NFIB CDK4
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.77	CDK4
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.77	MEN1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	9.77	MEN1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.77	FUS
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.77	MEN1 NFIB
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.77	FUS
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.77	CDK4
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.77	FUS
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.77	NFIB
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-3	9.77	FUS
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	9.77	NFIB
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	9.77	FUS
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.77	CDK4
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.77	MEN1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.77	CDK4
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.77	MEN1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.77	MEN1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-57	9.77	FUS
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.77	FUS
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-78	9.77	FUS
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.77	MEN1
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.77	CDK4

MGI Mouse Phenotypes related to Lipomatosis, Multiple:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.97	ALX3 CDK4 DES LPP MDM2 MEN1
2	digestive/alimentary	MP:0005381	9.87	ALX3 CDK4 MDM2 MEN1 MNX1 NFIB
3	homeostasis/metabolism	MP:0005376	9.81	ALX3 CDK4 DES LPP MDM2 MEN1
4	endocrine/exocrine gland	MP:0005379	9.8	ALX3 CDK4 MDM2 MEN1 MNX1 NFIB
5	mortality/aging	MP:0010768	9.61	NFIB PTEN ALX3 CDK4 DES LPP
6	muscle	MP:0005369	9.1	DES MDM2 MEN1 MNX1 PTEN CDK4

Sources

Drugs & Therapeutics for Lipomatosis, Multiple

Drugs for Lipomatosis, Multiple (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cortisone acetate

Approved, Investigational

Phase 1, Phase 2

1950-04-4, 50-04-4

5745

Isoproterenol

Approved, Investigational

Phase 1, Phase 2

7683-59-2

3779

Synonyms:

(-)-Isoproterenol hydrochloride

(+)-Isoprenaline

(+-)-Isoprenaline

(+)-Isoproterenol

(+-)-Isoproterenol

(±)-isoprenaline

(±)-isoproterenol

(S)-(+)-Isoproterenol

(S)-Isoprenaline

(S)-Isoproterenol

.alpha.-(Isopropylaminomoethyl)protocatechuyl alcohol

1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol

1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol

1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)- (9CI)

1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, (S)- (9CI)

149-53-1

2964-04-7

3,4-Dihydroxy-.alpha.-(isopropylaminomethyl)-benzyl alcohol

3,4-Dihydroxy-.alpha.-[(isopropylamino)methyl]benzyl alcohol

3,4-Dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol

3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol

3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol

3,4-Dihydroxy-α-[(isopropylamino)methyl]benzyl alcohol

3-13-00-02387 (Beilstein Handbook Reference)

4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol

4-(1-Hydroxy-2(isopropylamino)ethyl)-benzene 1,2-diol

4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol

46388-38-9

7683-59-2

a-(Isopropylaminomethyl)protocatechuyl alcohol

AC1L1GOZ

AC1Q1QBS

Aerolone

Aleudrin

Aleudrine

alpha-(Isopropylaminomethyl)protocatechuyl alcohol

Aludrin

Aludrine

Asiprenol

Asmalar

Assiprenol

Bellasthman

BRN 2213857

Bronkephrine

BSPBio_002208

C07056

CCRIS 3081

CHEMBL434

CID3779

D08090

DB01064

Dihydroxyphenylethanolisopropylamine

d-Isoprenaline

d-Isopropylarterenol

d-Isoproterenol

DivK1c_000894

DL(+-)-Isoproterenol

dl-Ipr

dl-Isadrine

dl-Isopropylnoradrenaline

DL-Isopropylnorepinephrine

dl-N-Isopropylnoradrenaline

d-N-Isopropylnorepinephrine

EINECS 231-687-7

Epinephrine isopropyl homolog

Epinephrine Isopropyl Homolog

Euspiran

HMS2089A12

Hydrochloride, isoproterenol

ICI 46399

IDI1_000894

IPA

Isadrin

Isadrine

Isonorene

Isonorin

Isoprenalin

Isoprenalina

Isoprenalina [INN-Spanish]

Isoprenaline

Isoprenaline (INN)

Isoprenaline hydrochloride

Isoprenalinum

Isoprenalinum [INN-Latin]

ISOPROP

Isopropydrin

Isopropyl noradrenaline

Isopropyladrenaline

Isopropylaminomethyl(3,4-dihydroxyphenyl)carbinol

Isopropylaminomethyl-3,4-dihydroxyphenyl carbinol

Isopropylarterenol

Isopropylnoradrenaline

Isopropylnorepinephrine

isoproterenol

Isoproterenol

Isoproterenol [JAN]

Isoproterenol chloride

Isoproterenol Chloride

Isoproterenol HCl

Isoproterenol hydrochloride

Isoproterenol sulfate

Isoproterenolum

Isorenin

Isuprel

Isuprel Mistometer

Isupren

Izadrin

KBio1_000894

KBio2_001429

KBio2_003997

KBio2_006565

KBio3_001428

KBioGR_000427

KBioSS_001429

L000936

l-Isopropylnoradrenaline

L-Isopropylnoradrenaline

l-Isoproterenol

L-Isoproterenol

Lomupren

Lopac0_000711

LS-42866

LS-42868

LS-42869

Medihaler-Iso

Medihaler-ISO

MolPort-001-783-449

NCGC00015558-08

NCGC00025274-03

NCGC00025274-04

NCGC00162220-01

nchembio.307-comp1

nchembio801-comp2

nchembio882-comp6

Neodrenal

neo-Epinine

Neo-Epinine

NINDS_000894

N-Isopropyl-b-dihydroxyphenyl-b-hydroxyethylamine

N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine

N-Isopropylnoradrenaline

N-Isopropylnorepinephrine

N-isopropyl-β-dihydroxyphenyl-β-hydroxyethylamine

N-Isopropyl-β-dihydroxyphenyl-β-hydroxyethylamine

Noradrenaline, isopropyl

Norisodrine

Norisodrine Aerotrol

Novodrin

NSC 33791

NSC 9975

NSC33791

NSC9975

Oprea1_009434

PDSP1_001425

PDSP2_001409

Prestwick0_001097

Prestwick1_001097

Prestwick2_001097

Proternol

Racemic isoprenaline

Racemic isoproterenol

Respifral

Saventrine

SGCUT00015

SPBio_001042

SPBio_003057

Spectrum_000949

Spectrum2_001061

Spectrum3_000474

Spectrum4_000024

Spectrum5_000880

STOCK1N-00740

Sulfate, isoproterenol

to_000062

UNII-L628TT009W

Vapo-Iso

Vapo-N-iso

WIN 5162

WLN: QR BQ DYQ1MY1&1

α-(isopropylaminomethyl)protocatechuyl alcohol

Methylprednisolone

Approved, Vet_approved

Phase 1, Phase 2

83-43-2

6741

Synonyms:

(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione

.DELTA.1-6.alpha.-Methylhydrocortisone

11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

121673-01-6

1-dehydro-6alpha-Methylhydrocortisone

1-Dehydro-6alpha-methylhydrocortisone

1-dehydro-6a-Methylhydrocortisone

1-dehydro-6α-methylhydrocortisone

4-08-00-03498 (Beilstein Handbook Reference)

46436_FLUKA

46436_RIEDEL

570-35-4

6 Methylprednisolone

6.alpha.-Methylprednisolone

6923-42-8

6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione

6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methylprednisolone

6-alpha-Methylprednisolone

6a-Methyl-11b,17a,21-triol-1,4-pregnadiene-3,20-dione

6-Methylprednisolone

6α-methyl-11β,17α,21-triol-1,4-pregnadiene-3,20-dione

83-43-2

AC1L1N7A

Artisone-wyeth

Artisone-Wyeth

Besonia

Bio-0658

BPBio1_000174

BRD-K35240538-001-03-1

BRN 2340300

BSPBio_000158

CHEBI:6888

CHEMBL650

CID6741

CPD000058330

D00407

D008775

DB00959

delta(1)-6alpha-Methylhydrocortisone

Delta(1)-6alpha-Methylhydrocortisone

delta(1)-6a-Methylhydrocortisone

delta(sup 1)-6-alpha-Methylhydrocortisone

Depo-Medrol (acetate)

Dopomedrol

EINECS 201-476-4

Esametone

Firmacort

HMS1568H20

HMS2090B13

HSDB 3127

Lemod

LMST02030178

LS-118498

M0639_SIGMA

M1665

Medesone

Medixon

Medlone 21

Medrate

Medric acid

Medrol

Medrol (TN)

Medrol adt pak

Medrol Adt Pak

Medrol dosepak

Medrol Dosepak

Medrol, Solu-Medrol, Medrone, Methylprednisolone

Medrone

MEPRDL

Mesopren

Metastab

Methyleneprednisolone

Methylprednisolon

methylprednisolone

Methylprednisolone

Methylprednisolone (JP15/USP/INN)

Methylprednisolone [USAN:INN:BAN:JAN]

Methylprednisolone, 6-alpha

Methylprednisolonum

Methylprednisolonum [INN-Latin]

methylprenisolone

Metilbetasone

Metilprednisolona

Metilprednisolona [INN-Spanish]

Metilprednisolone

Metilprednisolone [Dcit]

Metilprednisolone [DCIT]

Metipred

Metrisone

Metrocort

Metysolon

MLS000028541

MLS001148159

MLS002207191

Moderin

MolPort-002-528-554

NCGC00022735-03

NCI60_001657

Nirypan

Noretona

NSC19987

NSC-19987

Predni N Tablinen

Prednol- L

Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)

Prestwick_622

Prestwick0_000279

Prestwick1_000279

Prestwick2_000279

Prestwick3_000279

Promacortine

Reactenol

S1733_Selleck

SAM002589984

Sieropresol

SMR000058330

Solomet

SPBio_002377

Summicort

Suprametil

U 7532

UNII-X4W7ZR7023

Urbason

Urbasone

Wyacort

ZINC03875560

δ(1)-6a-methylhydrocortisone

δ(1)-6α-methylhydrocortisone

Prednisolone

Approved, Vet_approved

Phase 1, Phase 2

50-24-8

5755

Synonyms:

(11b)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

(11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione

.DELTA.1-Cortisol

.DELTA.1-Dehydrocortisol

.DELTA.1-Dehydrohydrocortisone

.DELTA.1-Hydrocortisone

.delta.-Cortef

.delta.-Stab

1,2-Dehydrohydrocortisone

1,4-Pregnadiene-11b,17a,21-triol-3,20-dione

1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione

1,4-Pregnadiene-3,20-dione-11b,17a,21-triol

1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol

1,4-Pregnadiene-3,20-dione-11β,17α,21-triol

1-Dehydrocortisol

1-Dehydrohydrocortisone

3,20-dioxo-11b,17a,21-Trihydroxy-1,4-pregnadiene

3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene

3,20-dioxo-11β,17α,21-trihydroxy-1,4-pregnadiene

46656_FLUKA

46656_RIEDEL

50-24-8

58201-11-9

8056-11-9

AC-1773

AC1L1L2E

Ak-Pred

Ak-Tate

Alphadrol

Articulose-50

Bio-0666

BPBio1_000164

BRD-K98039984-001-03-0

BRN 1354103

BSPBio_000148

Bubbli-Pred

C07369

CCRIS 980

CHEBI:8378

CHEMBL131

CID5755

Codelcortone

Co-Hydeltra

CO-Hydeltra

component of Ataraxoid

component of K-Predne-Dome

Cordrol

Cortalone

Cotogesic

Cotolone

CPD000718761

D00472

D011239

DB00860

Decaprednil

Decortin H

Delcortol

Delta F

delta(1)-Cortisol

delta(1)-Dehydrocortisol

Delta(1)-Dehydrocortisol

delta(1)-Dehydrohydrocortisone

Delta(1)-dehydrohydrocortisone

Delta(1)-Dehydrohydrocortisone

delta(1)-Hydrocortisone

Delta(1)-Hydrocortisone

delta(sup 1)-Cortisol

delta(sup 1)-Dehydrocortisol

delta(sup 1)-Dehydrohydrocortisone

delta(sup 1)-Hydrocortisone

Delta-Cortef

Delta-Cortef (TN)

Deltacortenol

Deltacortril

Deltacortril Enteric

delta-dehydrocortisol

delta-dehydrohydrocortisone

Delta-Ef-Cortelan

delta-hydrocortisone

Deltahydrocortisone

Deltasolone

Delta-stab

Delta-Stab

Deltisilone

Depo-Medrol

Derpo Pd

Derpo PD

Dexa-Cortidelt hostacortin H

Dexa-Cortidelt Hostacortin H

Di adreson F

Di Adreson F

Di-adreson F

Di-Adreson F

Di-adreson-F

DiAdresonF

Di-Adreson-F

Dicortol

Donisolone

Dydeltrone

Eazolin D

Econopred

Econopred Plus

EINECS 200-021-7

Erbacort

Erbasona

Estilsona

Fernisolone

Fernisolone P

Fernisolone-P

Flamasone

HMS1568H10

HMS2090J05

Hostacortin H

HSDB 3385

Hydeltra

Hydeltrasol

Hydeltra-Tba

Hydeltrone

Hydrodeltalone

Hydrodeltisone

Hydroretrocortin

Hydroretrocortine

Inflamase Forte

Inflamase Mild

I-Pred

K 1557

Key-Pred

Klismacort

Lentosone

Lite Pred

LMST02030179

LS-7669

Medrol

Medrol Acetate

Metacortandralone

Methylprednisolone acetate

Methylprednisolone Acetate

Meticortelone

Meti-Derm

Metreton

MLS001304083

MLS002154250

MLS002207037

MolPort-002-507-147

M-Predrol

NCGC00179649-01

Neo-Delta-Cortef

Nisolone

Nor-Pred T.B.A.

NSC 9120

NSC9120

NSC9900

Ocu-Pred

Ocu-Pred Forte

Ophtho-Tate

Orapred

P0152_SIGMA

P0637

P6004_SIGMA

Panafcortelone

Paracortol

Paracotol

Pediapred

Poly-Pred

PRDL

Precortalon

Precortancyl

Precortilon

Precortisyl

Pred Forte

Pred Mild

Predair

Predair A

Predair Forte

Predalone 50

Predalone T.B.A.

Predate

Predate Tba

Predate-50

Predcor-25

Predcor-50

Predcor-Tba

PRED-G

Predisolone sodium phosphate

Predisolone Sodium Phosphate

Predne-Dome

Prednelan

Prednicen

Predni-Dome

Predniliderm

Predniretard

Prednis

Prednisolona

Prednisolona [INN-Spanish]

prednisolone

Prednisolone (anhydrous)

Prednisolone (JP15/USP/INN)

Prednisolone [INN:BAN:JAN]

Prednisolone acetate

Prednisolone Acetate

Prednisolone sodium phosphate

Prednisolone Sodium Phosphate

Prednisolone tebutate

Prednisolone Tebutate

Prednisolonum

Prednisolonum [INN-Latin]

Predonin

Predonine

Prelone

Prenolone

Prestwick_404

Prestwick0_000274

Prestwick1_000274

Prestwick2_000274

Prestwick3_000274

Rolisone

S1737_Selleck

SAM002264639

Scherisolon

SMR000718761

Solone

SPBio_002367

Steran

Sterane

Sterolone

Supercortisol

Ulacort

Ultra Pred

Ultracorten H

Ultracortene H

Ultracortene-H

Ultracortene-hydrogen

Ultracortene-Hydrogen

UNII-9PHQ9Y1OLM

ZINC03833821

δ(1)-dehydrocortisol

δ(1)-dehydrohydrocortisone

δ(1)-hydrocortisone

deoxycholic acid

Approved

Phase 2,Phase 1

83-44-3

222528

Synonyms:

(3a,5a,12a)-3,12-DIHYDROXYCHOLAN-24-Oate

(3a,5a,12a)-3,12-DIHYDROXYCHOLAN-24-Oic acid

(3a,5b,12a)-3,12-Dihydroxycholan-24-Oate

(3a,5b,12a)-3,12-Dihydroxycholan-24-Oic acid

(3alpha,5alpha,12alpha)-3,12-DIHYDROXYCHOLAN-24-Oate

(3ALPHA,5ALPHA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID

(3alpha,5beta,12alpha)-3,12-Dihydroxycholan-24-Oate

(3alpha,5beta,12alpha)-3,12-Dihydroxycholan-24-Oic acid

(3α,5α,12α)-3,12-dihydroxycholan-24-Oate

(3α,5α,12α)-3,12-dihydroxycholan-24-Oic acid

(3α,5β,12α)-3,12-dihydroxycholan-24-Oate

(3α,5β,12α)-3,12-dihydroxycholan-24-oic acid

(3α,5β,12α)-3,12-dihydroxycholan-24-Oic acid

12beta-Isomer deoxycholic acid

3a,12a-Dihydroxy-5b-cholanate

3a,12a-Dihydroxy-5b-cholanic acid

3alpha,12alpha-Dihydroxy-5beta-cholanate

3alpha,12alpha-Dihydroxy-5beta-cholanic acid

3beta-Isomer deoxycholic acid

3α,12α-dihydroxy-5β-cholanate

3α,12α-dihydroxy-5β-cholanic acid

5alpha-Isomer deoxycholic acid

5b-Cholanic acid-3a,12a-diol

5b-Deoxycholate

5b-Deoxycholic acid

7a-Deoxycholate

7a-Deoxycholic acid

7alpha-Deoxycholate

7alpha-Deoxycholic acid

7-Deoxycholate

7-Deoxycholic acid

7α-deoxycholate

7α-deoxycholic acid

Acid, 5alpha-isomer deoxycholic

Acid, choleic

Acid, deoxycholic

Acid, desoxycholic

Acid, dihydroxycholanoic

Acid, lagodeoxycholic

Choleic acid

Cholerebic

Cholorebic

Degalol

Deoxycholatate

deoxycholate

Deoxycholate

Deoxy-cholate

Deoxycholate, sodium

Deoxycholatic acid

Deoxy-cholic acid

Deoxycholic acid, 12beta isomer

Deoxycholic acid, 12beta-isomer

Deoxycholic acid, 3beta isomer

Deoxycholic acid, 3beta-isomer

Deoxycholic acid, 5alpha isomer

Deoxycholic acid, 5alpha-isomer

Deoxycholic acid, disodium salt

Deoxycholic acid, magnesium (2:1) salt

Deoxycholic acid, monoammonium salt

Deoxycholic acid, monopotassium salt

Deoxycholic acid, monosodium salt

Deoxycholic acid, sodium salt, 12beta-isomer

Desoxycholate

desoxycholic acid

Desoxycholic acid

Desoxycholsaeure

Desoxycholsäure

Dihydroxycholanoic acid

Lagodeoxycholic acid

Sodium deoxycholate

Adrenergic Agents

Phase 1, Phase 2

Adrenergic Agonists

Phase 1, Phase 2

Adrenergic beta-Agonists

Phase 1, Phase 2

Anti-Asthmatic Agents

Phase 1, Phase 2

Antiemetics

Phase 1, Phase 2

Anti-Inflammatory Agents

Phase 1, Phase 2

Antineoplastic Agents, Hormonal

Phase 1, Phase 2

Autonomic Agents

Phase 1, Phase 2

Bronchodilator Agents

Phase 1, Phase 2

Cortisone

Phase 1, Phase 2

53-06-5

222786

Synonyms:

11-dehydro-17-Hydroxycorticosterone

17a,21-Dihydroxy-4-pregnene-3,11,20-trione

17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione

17-Hydroxy-11-dehydrocorticosterone

17α,21-dihydroxy-4-pregnene-3,11,20-trione

4-Pregnene-17a,21-diol-3,11,20-trione

4-Pregnene-17alpha,21-diol-3,11,20-trione

4-Pregnene-17α,21-diol-3,11,20-trione

Adreson

Andreson

Anusol HC

Balneol-HC

beta-HC

Colocort

Compound e

Corlin

Cortadren

Cortandren

Cortef

Cortef acetate

Cortisal

Cortisate

Cortison

Cortisone acetate

Cortistal

Cortivite

Cortogen

Cortone

Cortril

delta(4)-Pregnene-17a,21-diol-3,11,20-trione

Delta(4)-Pregnene-17alpha,21-diol-3,11,20-trione

Dermacort

Dricort

Flexicort

Florinef

Fludrocortisone acetate

Glycort

Hemsol-HC

Hi-cor

Incortin

Kendall'S compound

Kendall's compound e

Kortison

Locoid

Locoid lipocream

Micort-HC

Nogenic HC

Orabase hca

Pandel

Pregn-4-en-17a,21-diol-3,11,20-trione

Pregn-4-en-17alpha,21-diol-3,11,20-trione

Pregn-4-en-17α,21-diol-3,11,20-trione

Prestwick_132

Reichstein fa

Reichstein's substance fa

Scheroson

Solu-cortef

Stie-cort

Texacort

Westcort

Wintersteiner's compound F

δ(4)-pregnene-17a,21-diol-3,11,20-trione

δ(4)-pregnene-17α,21-diol-3,11,20-trione

Gastrointestinal Agents

Phase 1, Phase 2,Phase 2

glucocorticoids

Phase 1, Phase 2

Hormone Antagonists

Phase 1, Phase 2

Hormones

Phase 1, Phase 2

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 1, Phase 2

Methylprednisolone acetate

Phase 1, Phase 2

Methylprednisolone Hemisuccinate

Phase 1, Phase 2

Neuroprotective Agents

Phase 1, Phase 2

Neurotransmitter Agents

Phase 1, Phase 2

Peripheral Nervous System Agents

Phase 1, Phase 2

Pharmaceutical Solutions

Phase 1, Phase 2,Not Applicable

Prednisolone acetate

Phase 1, Phase 2

Prednisolone hemisuccinate

Phase 1, Phase 2

Prednisolone phosphate

Phase 1, Phase 2

Protective Agents

Phase 1, Phase 2

Respiratory System Agents

Phase 1, Phase 2

Cholagogues and Choleretics

Phase 2,Phase 1

Endothelial Growth Factors

Mitogens

Interventional clinical trials:

(show all 15)

#	Name	Status	NCT ID	Phase	Drugs
1	A Dose Escalation Study Using Collagenase Clostridium Histolyticum in the Treatment of Lipoma	Completed	NCT01613313	Phase 2	Collagenase Clostridium Histolyticum
2	Double Blind Study to Evaluate the Efficacy of Collagenase Histolyticum in the Treatment of Lipoma	Completed	NCT02249052	Phase 2	AA4500;placebo
3	Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas	Completed	NCT00624416	Phase 1, Phase 2	Prednisolone synthetic cortisone and Isoproterenol together
4	Phase 2 Study for the Treatment of Superficial Lipomas	Completed	NCT00608842	Phase 2	Deoxycholic Acid Injection;Placebo
5	Evaluation of Safety and Efficacy of RZL-012 for the Treatment of Lipedema or of Nodular Dercum's Disease	Recruiting	NCT03492840	Phase 2	RZL-012
6	Deoxycholic Acid Injection for the Treatment of Superficial Lipomas	Completed	NCT00422188	Phase 1	Deoxycholic Acid Injection;Placebo
7	Survey of Optical Values of the Breast Using Radiation-Free Pressure-Free Optical Scanning	Unknown status	NCT00671385
8	Ultra-sounded Guided Regional Blockade for Lipoma Excision	Completed	NCT02753361	Not Applicable
9	Pilot Study of Infrared Imaging of Cutaneous Melanoma	Completed	NCT00937690
10	Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors	Completed	NCT02884154	Not Applicable
11	Developing a Biomarker for Monitoring Clinical Outcomes in Children With Spinal Lipoma.	Recruiting	NCT02722681
12	Periampullary Lesions Via ERCP in Assuit University Hospital	Recruiting	NCT03185390	Not Applicable
13	Insight Into Subcutaneous Adipose Tissue Disorders	Recruiting	NCT02838277
14	Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 Lesions	Recruiting	NCT02638935	Not Applicable
15	Identification of Biomarkers for Patients With Vascular Anomalies	Recruiting	NCT03001180

Search NIH Clinical Center for Lipomatosis, Multiple

Cochrane evidence based reviews: neoplasms, adipose tissue

Sources

Genetic Tests for Lipomatosis, Multiple

Genetic tests related to Lipomatosis, Multiple:

#	Genetic test	Affiliating Genes
1	Lipoma ²⁹
2	Lipomatosis, Multiple ²⁹

Sources

Anatomical Context for Lipomatosis, Multiple

MalaCards organs/tissues related to Lipomatosis, Multiple:

⁴¹

Bone, Endothelial, Skin, Kidney, Brain

Sources

Publications for Lipomatosis, Multiple

Articles related to Lipomatosis, Multiple:

(show all 16)

#	Title	Authors	Year
1	Subcutaneous Nodules in a Kidney Transplant Recipient: Familial Multiple Lipomatosis. ( 27206607 )	Prieto-Barrios M....Burillo-MartA-nez S.	2016
2	Gastroduodenal Lipomatosis in the Familial Multiple Lipomatosis. ( 27884011 )	Djuric-Stefanovic A....Saranovic D.	2016
3	A rare combination between familial multiple lipomatosis and extragastrointestinal stromal tumor. ( 26263450 )	Arabadzhieva E....Dimitrova V.	2015
4	Images in clinical medicine. Familial multiple lipomatosis. ( 25251618 )	Tana C....Tchernev G.	2014
5	Brain lipoma, corpus callosum hypoplasia and polymicrogyria in familial multiple lipomatosis. ( 23116686 )	Nunes J.C....Walz R.	2013
6	Insulin sensitivity in Familial Multiple Lipomatosis. ( 23893194 )	D'Ettorre M....Mingrone G.	2013
7	Cytophagic histiocytic panniculitis with haemophagocytosis in a patient with familial multiple lipomatosis and review of the literature. ( 21732050 )	Krilis M....Miyakis S.	2012
8	Familial multiple lipomatosis with clear autosomal dominant inheritance and onset in early adolescence. ( 22707495 )	Lee C.H....Morrison P.J.	2011
9	Familial multiple lipomatosis: a case report. ( 20306922 )	Veger H.T....da Costa S.A.	2010
10	Encephalocraniocutaneous lipomatosis (ECCL) in a patient with history of familial multiple lipomatosis (FML). ( 19215040 )	Prontera P....Donti E.	2009
11	Familial multiple lipomatosis: report of a new family. ( 17674589 )	Gologorsky Y....Zirwas M.J.	2007
12	Lipolysis of lipomas in patients with familial multiple lipomatosis: an ultrasonography-controlled trial. ( 17234112 )	Bechara F.G....Hoffmann K.	2006
13	Familial multiple lipomatosis. ( 14594582 )	Toy B.R.	2003
14	Familial multiple lipomatosis. ( 12516905 )	Keskin D....Celik H.	2002
15	Minimally invasive approach to familial multiple lipomatosis. ( 11007403 )	Ronan S.J....Broderick T.	2000
16	Familial multiple lipomatosis. Report of a case and a review of the literature. ( 3745530 )	Leffell D.J....BRAVERMAN I.M.	1986

Sources

Genes for Lipomatosis, Multiple

Genes related to Lipomatosis, Multiple (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	28.44	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	18663748 19431195 10329012 (more) 12781451 9212729 15755872 19528502 10744071 9772904 18383898 9403060 8889500 16375854 10519386 7606786 17372913 8824803 9244875 10472377 8637707 12970064 17045619 19837271 19433298 15202015 9495195 19963137 14603445 11566348 10727978 10824997 12063392 11391797 10747931 9598796 9466569 19346081 12021922 10998430 10637295 18381458 17332316 9696033 16133369 14612541 16276091 11921278 17370328 11576996 12206982 15882911 8791483
2	MDM2	MDM2 Proto-Oncogene	Protein Coding	24.72	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	14694526 11518050 9071998 (more) 7519048 7591308 18779733 10755400 9703873 15242313 10727978 17372913 7656201 19820690
3	LPP	LIM Domain Containing Preferred Translocation Partner In Lipoma	Protein Coding	23.98	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	9772904 10637295 9598796
4	CDK4	Cyclin Dependent Kinase 4	Protein Coding	23.41	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	14694526 10755400 10727978 (more) 20063101 15154619 9703873 17372913
5	MEN1	Menin 1	Protein Coding	22.97	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	19596783 11381507 11571558
6	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	22.38	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	9212729 10744071 12970064 (more) 9187132 10472377 9824199 8824803 17370328
7	FUS	FUS RNA Binding Protein	Protein Coding	21.96	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	9244875
8	PTEN	Phosphatase And Tensin Homolog	Protein Coding	20.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	15920539 16952599 17526800 (more) 9832032 10400993 10749983 11571558
9	DES	Desmin	Protein Coding	17.18	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	15322874 9331894 17585537
10	LHFPL6	LHFPL Tetraspan Subfamily Member 6	Protein Coding	16.26	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	ALX3	ALX Homeobox 3	Protein Coding	16.09	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	MNX1	Motor Neuron And Pancreas Homeobox 1	Protein Coding	16.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	NFIB	Nuclear Factor I B	Protein Coding	15.77	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for Lipomatosis, Multiple

Copy number variations for Lipomatosis, Multiple from CNVD:

⁷

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	173076	3	189413414	190080135	Translate	LPP	Lipoma

Sources

Expression for Lipomatosis, Multiple

Search GEO for disease gene expression data for Lipomatosis, Multiple.

Sources

Pathways for Lipomatosis, Multiple

Pathways related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	11.88	CDK4 MDM2 PTEN
2	Chromatin Regulation / Acetylation ⁴	11.86	FUS HMGA1 HMGA2 MEN1
3	Cellular senescence (KEGG) ³⁷	11.78	CDK4 MDM2 PTEN
4	Integrated Breast Cancer Pathway ¹	11.73	CDK4 MDM2 PTEN
5	Glioblastoma Multiforme ⁶⁴	11.54	CDK4 MDM2 PTEN
6	Transcriptional misregulation in cancer ³⁷	11.53	FUS HMGA2 MDM2 MEN1
7	Senescence and Autophagy in Cancer ¹	11.46	HMGA1 MDM2 PTEN
8	Oncogene Induced Senescence ⁶⁶	10.96	CDK4 MDM2
9	Integrated Cancer Pathway ¹	10.46	CDK4 MDM2 PTEN

Sources

GO Terms for Lipomatosis, Multiple

Cellular components related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:0005634	9.4	ALX3 CDK4 DES FUS HMGA1 HMGA2
2	chromatin	GO:0000785	9.33	CDK4 HMGA2 MEN1
3	senescence-associated heterochromatin focus	GO:0035985	8.96	HMGA1 HMGA2

Biological processes related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of transcription, DNA-templated	GO:0006355	9.98	ALX3 FUS HMGA1 HMGA2 MEN1 MNX1
2	negative regulation of transcription, DNA-templated	GO:0045892	9.76	HMGA1 HMGA2 MDM2 MEN1
3	negative regulation of cell proliferation	GO:0008285	9.67	HMGA1 MEN1 NFIB PTEN
4	negative regulation of cell cycle arrest	GO:0071157	9.4	CDK4 MDM2
5	cellular response to peptide hormone stimulus	GO:0071375	9.32	MDM2 MEN1
6	positive regulation of cellular senescence	GO:2000774	9.26	HMGA1 HMGA2
7	negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle	GO:0031658	9.16	CDK4 PTEN
8	senescence-associated heterochromatin focus assembly	GO:0035986	8.96	HMGA1 HMGA2
9	oncogene-induced cell senescence	GO:0090402	8.62	HMGA1 HMGA2

Molecular functions related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA binding	GO:0003677	9.91	ALX3 FUS HMGA1 HMGA2 MEN1 MNX1
2	enzyme binding	GO:0019899	9.56	HMGA1 HMGA2 MDM2 PTEN
3	ionotropic glutamate receptor binding	GO:0035255	9.4	FUS PTEN
4	retinoid X receptor binding	GO:0046965	9.32	FUS HMGA1
5	DNA-(apurinic or apyrimidinic site) endonuclease activity	GO:0003906	9.16	HMGA1 HMGA2
6	peroxisome proliferator activated receptor binding	GO:0042975	8.96	HMGA1 MDM2
7	AT DNA binding	GO:0003680	8.62	HMGA1 HMGA2

Sources

Sources for Lipomatosis, Multiple

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia