FML
MCID: LPM012
MIFTS: 64

Lipomatosis, Multiple (FML)

Categories: Cancer diseases, Genetic diseases, Metabolic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Lipomatosis, Multiple

MalaCards integrated aliases for Lipomatosis, Multiple:

Name: Lipomatosis, Multiple 57 29 73
Lipoma 57 12 29 55 15 73
Lipomatosis, Familial Multiple 57 12
Familial Multiple Lipomatosis 53 59
Benign Lipomatous Tumor 12 73
Multiple Lipomatosis 12 53
Lipomatous Neoplasm 12 73
Lipomatosis, Familial Multiple; Fml 57
Benign Tumor of Adipose Tissue 12
Neoplasms, Adipose Tissue 44
Tumor of Adipose Tissue 12
Lipomatous Tumor 12
Lipoma; Lipo 57
Lipo 57
Fml 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
lipomatosis, multiple:
Inheritance autosomal dominant inheritance


Classifications:

Orphanet: 59  
Rare skin diseases


Summaries for Lipomatosis, Multiple

NIH Rare Diseases : 53 Familial multiple lipomatosis (FML) is a rare condition that is characterized by multiple lipomas on the trunk and extremities. As the name suggests, FML is diagnosed when multiple lipomatosis occurs in more than one family member, often over several generations. The lipomas associated with FML are usually painless, but may impact quality of life as they can be numerous and large. Although the condition appears to be passed down through families in an autosomal dominant manner, the underlying genetic cause is currently unknown. Treatment is based on the signs and symptoms present in each person. Surgical excision may be necessary if the tumors interfere with movement and/or daily life.

MalaCards based summary : Lipomatosis, Multiple, also known as lipoma, is related to skin lipoma and spindle cell lipoma. An important gene associated with Lipomatosis, Multiple is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are p53 Signaling and Chromatin Regulation / Acetylation. The drugs Afinitor and Avastin have been mentioned in the context of this disorder. Affiliated tissues include colon, skin and bone, and related phenotypes are macrocephaly and seizures

Disease Ontology : 12 A cell type benign neoplasm that is composed of lipocytes.

OMIM : 57 Familial multiple lipomatosis is a rare autosomal dominant disorder characterized by numerous encapsulated lipomas on the trunk and extremities (Keskin et al., 2002). (151900)

Wikipedia : 76 A lipoma is a benign tumor made of fat tissue. They are generally soft to the touch, movable, and... more...

Related Diseases for Lipomatosis, Multiple

Diseases in the Lipomatosis family:

Lipomatosis, Multiple

Diseases related to Lipomatosis, Multiple via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 448)
# Related Disease Score Top Affiliating Genes
1 skin lipoma 33.8 PTEN HMGA2
2 spindle cell lipoma 33.7 MDM2 DES CDK4
3 chondroid lipoma 33.5 MEN1 MDM2 FUS CDK4
4 infiltrating lipoma 33.4 MDM2 LPP HMGA2 CDK4
5 well-differentiated liposarcoma 32.5 MDM2 HMGA2 CDK4
6 pleomorphic lipoma 32.1 MDM2 HMGA2
7 atypical lipomatous tumor 32.0 MDM2 HMGA2 FUS CDK4
8 liposarcoma 30.6 MDM2 HMGA2 FUS DES CDK4
9 lipomatosis 30.4 UCP1 PTEN MEN1 HMGA2
10 lipoblastoma 30.3 MDM2 CDK4
11 pleomorphic liposarcoma 29.9 MDM2 DES
12 myxoid liposarcoma 29.9 MDM2 HMGA2 FUS CDK4
13 hemangiopericytoma, malignant 29.8 DES MDM2
14 dedifferentiated liposarcoma 29.8 MDM2 HMGA2 DES CDK4
15 infiltrating angiolipoma 29.8 MDM2 CDK4
16 spindle cell liposarcoma 29.7 MDM2 CDK4
17 cellular myxoid liposarcoma 29.6 MDM2 FUS CDK4
18 leiomyosarcoma 29.5 MDM2 DES CDK4
19 lipomatosis, multiple symmetric 12.5
20 nasopalpebral lipoma-coloboma syndrome 12.4
21 chest wall lipoma 12.3
22 pleural lipoma 12.3
23 spinal cord lipoma 12.3
24 lipoma of spermatic cord 12.3
25 tendon sheath lipoma 12.3
26 hemihyperplasia-multiple lipomatosis syndrome 12.3
27 thymus lipoma 12.3
28 large intestine lipoma 12.2
29 gallbladder lipoma 12.2
30 extrahepatic bile duct lipoma 12.2
31 central nervous system lipoma 12.2
32 epicardium lipoma 12.2
33 lipoma of colon 12.2
34 corpus callosum lipoma 12.2
35 endobronchial lipoma 12.1
36 breast lipoma 12.1
37 axillary lipoma 12.1
38 lumbosacral lipoma 12.1
39 esophageal lipoma 12.1
40 liver lipoma 12.1
41 internal auditory canal lipoma 12.1
42 lipoma of the rectum 12.1
43 classic type lipoma 12.1
44 paratesticular lipoma 12.1
45 cleft, median, of upper lip with polyps of facial skin and nasal mucosa 12.1
46 lipoma of the conjunctiva 12.0
47 kidney lipoma 12.0
48 external auditory meatus lipoma 12.0
49 cerebral hemisphere lipoma 12.0
50 cowden syndrome 1 11.9

Graphical network of the top 20 diseases related to Lipomatosis, Multiple:



Diseases related to Lipomatosis, Multiple

Symptoms & Phenotypes for Lipomatosis, Multiple

Symptoms via clinical synopsis from OMIM:

57
Skin:
lipomatosis

Lab:
frequent rearrangements at 12q13 or 12q14


Clinical features from OMIM:

151900

Human phenotypes related to Lipomatosis, Multiple:

59 32 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 macrocephaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0000256
2 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
3 cerebral calcification 59 32 occasional (7.5%) Occasional (29-5%) HP:0002514
4 bowing of the long bones 59 32 occasional (7.5%) Occasional (29-5%) HP:0006487
5 delayed speech and language development 59 32 occasional (7.5%) Occasional (29-5%) HP:0000750
6 peripheral neuropathy 59 32 frequent (33%) Frequent (79-30%) HP:0009830
7 lipodystrophy 59 32 hallmark (90%) Very frequent (99-80%) HP:0009125
8 ventriculomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0002119
9 hyperlipidemia 59 32 frequent (33%) Frequent (79-30%) HP:0003077
10 accelerated skeletal maturation 59 32 occasional (7.5%) Occasional (29-5%) HP:0005616
11 increased adipose tissue 59 32 hallmark (90%) Very frequent (99-80%) HP:0009126
12 hypoplasia of the corpus callosum 59 32 occasional (7.5%) Occasional (29-5%) HP:0002079
13 insulin resistance 59 32 hallmark (90%) Very frequent (99-80%) HP:0000855
14 arachnoid cyst 59 32 occasional (7.5%) Occasional (29-5%) HP:0100702
15 coloboma 59 32 occasional (7.5%) Occasional (29-5%) HP:0000589
16 overgrowth 59 32 occasional (7.5%) Occasional (29-5%) HP:0001548
17 medulloblastoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0002885
18 functional intestinal obstruction 59 32 frequent (33%) Frequent (79-30%) HP:0005249
19 premature eruption of permanent teeth 59 32 occasional (7.5%) Occasional (29-5%) HP:0006337
20 chorioretinitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012424
21 multiple lipomas 32 HP:0001012
22 abnormality of the tricuspid valve 59 Occasional (29-5%)
23 keratocystic odontogenic tumor 59 Occasional (29-5%)
24 odontogenic keratocysts of the jaw 32 occasional (7.5%) HP:0010603
25 abnormal tricuspid valve morphology 32 occasional (7.5%) HP:0001702

MGI Mouse Phenotypes related to Lipomatosis, Multiple:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 ALX3 CDK4 DES LPP MDM2 MEN1
2 homeostasis/metabolism MP:0005376 9.81 ALX3 CDK4 DES LPP MDM2 MEN1
3 digestive/alimentary MP:0005381 9.73 ALX3 CDK4 MDM2 MEN1 MNX1 PTEN
4 mortality/aging MP:0010768 9.61 ALX3 CDK4 DES LPP MDM2 MEN1
5 muscle MP:0005369 9.1 CDK4 DES MDM2 MEN1 MNX1 PTEN

Drugs & Therapeutics for Lipomatosis, Multiple

FDA approved drugs:

(show all 8)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Afinitor 18 49 EVEROLIMUS Novartis March 2009
2
Avastin 18 49 BEVACIZUMAB Genentech July 2009
3
Doxil 18 49 DOXORUBICIN HYDROCHLORIDE Alza June 1999
4
Marqibo 18 49 VINCRISTINE SULFATE Talon Therapeutics August 2012
5
DuoNeb 18 ALBUTEROL SULFATE; IPRATROPIUM BROMIDE Dey Laboratories March 2001
6
Rayos 18 PREDNISONE Horizon Pharma July of 2012
7
Vibativ 18 * TELAVANCIN * TELAVANCIN HYDROCHLORIDE Theravance June 2013
8
Zyflo 18 ZILEUTON Abbott Laboratories January 1997

Drugs for Lipomatosis, Multiple (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
4
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
5
Cortisone acetate Approved, Investigational Phase 1, Phase 2 1950-04-4, 50-04-4 5745
6
Isoproterenol Approved, Investigational Phase 1, Phase 2 7683-59-2 3779
7
deoxycholic acid Approved Phase 2,Phase 1 83-44-3 222528
8
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
9
Cortisone Experimental Phase 1, Phase 2 53-06-5 222786
10 Pharmaceutical Solutions Phase 1, Phase 2,Not Applicable
11 Sympathomimetics Phase 1, Phase 2
12 Respiratory System Agents Phase 1, Phase 2
13 Adrenergic beta-Agonists Phase 1, Phase 2
14 Antineoplastic Agents, Hormonal Phase 1, Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
16 Hormones Phase 1, Phase 2
17 Adrenergic Agonists Phase 1, Phase 2
18 Anti-Inflammatory Agents Phase 1, Phase 2
19 Hormone Antagonists Phase 1, Phase 2
20 Prednisolone acetate Phase 1, Phase 2
21 Peripheral Nervous System Agents Phase 1, Phase 2
22 Bronchodilator Agents Phase 1, Phase 2
23 Gastrointestinal Agents Phase 1, Phase 2,Phase 2
24 Neuroprotective Agents Phase 1, Phase 2
25 Autonomic Agents Phase 1, Phase 2
26 Anti-Asthmatic Agents Phase 1, Phase 2
27 Antiemetics Phase 1, Phase 2
28 glucocorticoids Phase 1, Phase 2
29 Neurotransmitter Agents Phase 1, Phase 2
30 Adrenergic Agents Phase 1, Phase 2
31 Protective Agents Phase 1, Phase 2
32 Cardiotonic Agents Phase 1, Phase 2
33 Methylprednisolone acetate Phase 1, Phase 2
34 Cholagogues and Choleretics Phase 2,Phase 1
35 Endothelial Growth Factors
36 Mitogens

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 A Dose Escalation Study Using Collagenase Clostridium Histolyticum in the Treatment of Lipoma Completed NCT01613313 Phase 2 Collagenase Clostridium Histolyticum
2 Double Blind Study to Evaluate the Efficacy of Collagenase Histolyticum in the Treatment of Lipoma Completed NCT02249052 Phase 2 AA4500;placebo
3 Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas Completed NCT00624416 Phase 1, Phase 2 Prednisolone synthetic cortisone and Isoproterenol together
4 Phase 2 Study for the Treatment of Superficial Lipomas Completed NCT00608842 Phase 2 Deoxycholic Acid Injection;Placebo
5 Evaluation of Safety and Efficacy of RZL-012 for the Treatment of Lipedema or of Nodular Dercum's Disease Recruiting NCT03492840 Phase 2 RZL-012
6 Deoxycholic Acid Injection for the Treatment of Superficial Lipomas Completed NCT00422188 Phase 1 Deoxycholic Acid Injection;Placebo
7 Developing a Biomarker for Monitoring Clinical Outcomes in Children With Spinal Lipoma. Unknown status NCT02722681
8 Survey of Optical Values of the Breast Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
9 Ultra-sounded Guided Regional Blockade for Lipoma Excision Completed NCT02753361 Not Applicable
10 Periampullary Lesions Via ERCP in Assuit University Hospital Recruiting NCT03185390 Not Applicable
11 Pilot Study of Infrared Imaging of Cutaneous Melanoma Completed NCT00937690
12 Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors Completed NCT02884154 Not Applicable
13 Insight Into Subcutaneous Adipose Tissue Disorders Recruiting NCT02838277
14 Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 Lesions Recruiting NCT02638935 Not Applicable
15 Identification of Biomarkers for Patients With Vascular Anomalies Recruiting NCT03001180

Search NIH Clinical Center for Lipomatosis, Multiple

Cochrane evidence based reviews: neoplasms, adipose tissue

Genetic Tests for Lipomatosis, Multiple

Genetic tests related to Lipomatosis, Multiple:

# Genetic test Affiliating Genes
1 Lipoma 29
2 Lipomatosis, Multiple 29

Anatomical Context for Lipomatosis, Multiple

MalaCards organs/tissues related to Lipomatosis, Multiple:

41
Colon, Skin, Bone, Spinal Cord, Tongue, Liver, Kidney

Publications for Lipomatosis, Multiple

Articles related to Lipomatosis, Multiple:

(show top 50) (show all 573)
# Title Authors Year
1
Spindle cell lipoma mimicking pleomorphic adenoma: A diagnostic challenge on cytology. ( 30468314 )
2018
2
Tubular adenoma overlying a colonic lipoma resected by endoscopic mucosal resection using detachable endoloop. ( 30503845 )
2018
3
Lipoma of the transverse colon covered by tubulovillous adenoma: a rare indication for surgical treatment. ( 29549684 )
2018
4
Intussusception secondary to descending colon lipoma presenting with simultaneous acute appendicitis. ( 29992005 )
2018
5
Coincidence of Tethered Cord, Filum Terminale Lipoma, and Sacral Dural Arteriovenous Fistula: Report of Two Cases and a Literature Review. ( 30319536 )
2018
6
Carpal Tunnel Syndrome Caused by Intraneural Lipoma of the Median Nerve and Arteriovenous Malformation. ( 29731590 )
2018
7
Capillary hemangioma involved in filar lipoma: A case report. ( 30309451 )
2018
8
Obesity and pericallosal lipoma in X-linked emery-dreifuss muscular dystrophy: A case report - Does Emerin play a role in adipocyte differentiation? ( 30079154 )
2018
9
Endobronchial lipoma with tuberculosis: A solitary coetaneousness. ( 29319046 )
2018
10
Pericallosal Lipoma and Cortical Dysplasia Masquerading as a Glioma. ( 30083489 )
2018
11
Complete small bowel obstruction without intussusception due to a submucosal lipoma. ( 29992008 )
2018
12
Colonic intussusception caused by a sigmoidal lipoma: A case report. ( 30059860 )
2018
13
Pedunculated small bowel lipoma with heterotopic pancreas causing intussusception. ( 30214784 )
2018
14
Laparoscopic segmental resection of the rectum for upper rectal intussusception caused by a giant rectal lipoma: A case report. ( 30278497 )
2018
15
Intussusception of colonic lipoma with ischaemic necrosis: a new colonoscopic finding. ( 30294849 )
2018
16
Ileoileal and ileocecal intussusception due to ileal lipoma: A rare cause of bowel obstruction in the adult. ( 28684032 )
2018
17
An intraspinal extradural lipoma with spinal epidural lipomatosis: A case report and a review of literature. ( 30488010 )
2018
18
Liposarcoma of the spermatic cord associated with scrotum lipoma: A case report and review of the literature. ( 29541595 )
2018
19
Liposarcoma Preoperatively Diagnosed as Lipoma: 10-Year Experience at a Single Institution. ( 29659409 )
2018
20
Successful removal of giant mediastinal lipoma and liposarcoma involving both chest cavities: Two case reports. ( 30095647 )
2018
21
Fatty tumors of the retroperitoneum: Lipoma or well-differentiated liposarcoma. About a case of a giant retroperitoneal liposarcoma. ( 30211007 )
2018
22
Multiple well-differentiated cardiac liposarcoma with a concomitant myocardial lipoma: A case report. ( 30546890 )
2018
23
Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10. ( 30303149 )
2018
24
Simultaneous Median and Ulnar Compression Neuropathy Secondary to a Giant Palmar Lipoma: A Case Report and Review of the Literature. ( 29666776 )
2018
25
Pleural lipoma presenting with back pain. ( 27323307 )
2018
26
Transient Anarthria and Quadriplegia in a Patient with Basilar Artery Hypoplasia and Coincidental Intracranial Lipoma: A Case Report. ( 30519181 )
2018
27
Dysplastic Lipoma: A Distinctive Atypical Lipomatous Neoplasm With Anisocytosis, Focal Nuclear Atypia, p53 Overexpression, and a Lack of MDM2 Gene Amplification by FISH; A Report of 66 Cases Demonstrating Occasional Multifocality and a Rare Association With Retinoblastoma. ( 30001242 )
2018
28
Giant bipolar intramedullary nondysraphic spinal cord lipoma: A case report. ( 30396693 )
2018
29
Intramedullary Spinal Cord Lipoma Mimicking a Late Subacute Hematoma. ( 30459918 )
2018
30
Low-fat, plexiform spindle cell lipoma of the lip expressing S100 protein: a neural tumor simulator. ( 29940654 )
2018
31
Pericallosal lipoma masquerading as venous thrombosis on magnetic resonance imaging. ( 30504604 )
2018
32
Gastrointestinal: Gastric lipoma as a rare cause of recurrent gastrointestinal bleeding. ( 29542245 )
2018
33
Giant pericallosal lipoma presenting with psychosis. ( 29547194 )
2018
34
Cardiac Lipoma: An Uncharacteristically Large Intra-Atrial Mass Causing Symptoms. ( 29552360 )
2018
35
Medical image analysis of knee joint lipoma arborescens and arthroscopic treatment. ( 29567561 )
2018
36
Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells. ( 29568880 )
2018
37
A case of junctional neural tube defect associated with a lipoma of the filum terminale: a new subtype of junctional neural tube defect? ( 29600904 )
2018
38
Preoperative radiologic patent blue localization for intracorporeal laparoscopic resection of a terminal ileal submucosal lipoma: A case report. ( 29604532 )
2018
39
Accessory scrotum and congenital perineal lipoma in a child with type 2 congenital pulmonary airway malformation: A report of an unusual. ( 29623024 )
2018
40
Frontal subcutaneous lipoma associated with interhemispheric lipoma, lipomeningocele, and corpus callosal dysgenesis in a young adult: CT and MRI findings. ( 29692522 )
2018
41
An Incidental Periscapular Lipoma With Marked Bone Erosion in an Elderly Woman With Contralateral Shoulder Pain. ( 29705170 )
2018
42
Para-anal lipoma as a rare consequence to perineal trauma. Case-report and review of the literature. ( 29734868 )
2018
43
A Large Size Lipoma at Spinoglenoid Notch Mimicked Traumatic Rotator Cuff Tear. ( 29734906 )
2018
44
A case report of multi-compartmental lipoma of the hand. ( 29736408 )
2018
45
Thoracoscopic resection of parosteal lipoma of the rib using orthopedic electric micro drill. ( 29744749 )
2018
46
Noninvasive size reduction of lipoma with an insulated monopolar radiofrequency microneedle device. ( 29744986 )
2018
47
Retropharyngeal lipoma presenting with snoring in a child. ( 29752203 )
2018
48
Giant ileocecal submucosal lipoma presenting with hematochezia. ( 29752793 )
2018
49
Intralesional Injection of Triamcinolone Acetonide for Subcutaneous Lipoma causing Musculoskeletal and Neurologic Symptoms. ( 29785238 )
2018
50
A Rare Case of Incidental Tracheal Lipoma. ( 29803520 )
2018

Variations for Lipomatosis, Multiple

Copy number variations for Lipomatosis, Multiple from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 173076 3 189413414 190080135 Translate LPP Lipoma

Expression for Lipomatosis, Multiple

Search GEO for disease gene expression data for Lipomatosis, Multiple.

Pathways for Lipomatosis, Multiple

Pathways related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 CDK4 MDM2 PTEN
2 11.86 FUS HMGA1 HMGA2 MEN1
3 11.79 CDK4 MDM2 PTEN
4 11.78 CDK4 MDM2 PTEN
5 11.73 CDK4 MDM2 PTEN
6 11.54 CDK4 MDM2 PTEN
7 11.53 FUS HMGA2 MDM2 MEN1
8 11.46 HMGA1 MDM2 PTEN
9 10.98 CDK4 MDM2
10 10.46 CDK4 MDM2 PTEN

GO Terms for Lipomatosis, Multiple

Cellular components related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.7 ALX3 CDK4 DES FUS HMGA1 HMGA2
2 chromatin GO:0000785 9.33 CDK4 HMGA2 MEN1
3 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA1 HMGA2

Biological processes related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.71 HMGA1 HMGA2 MDM2 MEN1
2 negative regulation of cell cycle arrest GO:0071157 9.37 CDK4 MDM2
3 cellular response to peptide hormone stimulus GO:0071375 9.32 MDM2 MEN1
4 positive regulation of cellular senescence GO:2000774 9.26 HMGA1 HMGA2
5 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.16 CDK4 PTEN
6 senescence-associated heterochromatin focus assembly GO:0035986 8.96 HMGA1 HMGA2
7 oncogene-induced cell senescence GO:0090402 8.62 HMGA1 HMGA2

Molecular functions related to Lipomatosis, Multiple according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ionotropic glutamate receptor binding GO:0035255 9.32 FUS PTEN
2 retinoid X receptor binding GO:0046965 9.26 FUS HMGA1
3 peroxisome proliferator activated receptor binding GO:0042975 9.16 HMGA1 MDM2
4 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 8.96 HMGA1 HMGA2
5 AT DNA binding GO:0003680 8.62 HMGA1 HMGA2

Sources for Lipomatosis, Multiple

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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