LPG
MCID: LPP002
MIFTS: 47

Lipoprotein Glomerulopathy (LPG)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Lipoprotein Glomerulopathy

MalaCards integrated aliases for Lipoprotein Glomerulopathy:

Name: Lipoprotein Glomerulopathy 57 59 75 37 29 13 6 40 73
Lpg 57 59 75

Characteristics:

Orphanet epidemiological data:

59
lipoprotein glomerulopathy
Inheritance: Autosomal dominant; Age of onset: All ages;

Classifications:



External Ids:

OMIM 57 611771
Orphanet 59 ORPHA329481
UMLS via Orphanet 74 C2673196
ICD10 via Orphanet 34 N07.8
MedGen 42 C2673196
KEGG 37 H00887
UMLS 73 C2673196

Summaries for Lipoprotein Glomerulopathy

OMIM : 57 Lipoprotein glomerulopathy is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries (Saito et al., 2006). It mainly affects people of Japanese and Chinese origin; in these populations, it is associated with mutations in the gene that encodes apolipoprotein E (APOE; 107741). The disorder had rarely been described in Caucasians. (611771)

MalaCards based summary : Lipoprotein Glomerulopathy, also known as lpg, is related to nephrotic syndrome and burns. An important gene associated with Lipoprotein Glomerulopathy is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Affiliated tissues include kidney, endothelial and brain, and related phenotypes are renal insufficiency and proteinuria

UniProtKB/Swiss-Prot : 75 Lipoprotein glomerulopathy: Uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries.

Related Diseases for Lipoprotein Glomerulopathy

Diseases related to Lipoprotein Glomerulopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 nephrotic syndrome 10.3
2 burns 10.2
3 streptococcal group a invasive disease 10.2
4 xanthoma disseminatum 10.1 APOB APOE
5 hyperlipoproteinemia, type v 10.1 APOB APOE
6 ischemic heart disease 10.1 APOB APOE
7 hypertriglyceridemia, familial 10.1 APOB APOE
8 hypobetalipoproteinemia, familial, 2 10.1 APOB LPA
9 hyperlipoproteinemia, type iv 10.1 APOA2 APOB
10 fetal macrosomia 10.0 APOB LCAT
11 coronary stenosis 10.0 APOB APOE
12 amyloidosis aa 10.0 LCAT LPA
13 fish-eye disease 10.0 APOA2 LCAT
14 hearing loss, noise-induced 10.0
15 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
16 localized scleroderma 10.0
17 niemann-pick disease, type b 10.0 LCAT LPA
18 exfoliation syndrome 10.0 APOE CLU
19 amyloidosis, familial visceral 10.0 APOA2 LPA
20 huntington disease-like 1 10.0 APOB APOE LPA
21 carotid artery disease 10.0 APOB APOE LPA
22 gallbladder disease 10.0 APOB APOE
23 arteriosclerosis 10.0 APOB APOE LPA
24 schnyder corneal dystrophy 10.0 APOA2 APOB APOE
25 stroke, ischemic 9.9 APOB APOE LPA
26 pick disease of brain 9.9 APOE CLU
27 smith-lemli-opitz syndrome 9.9 APOE LDLR
28 hyperlipidemia, familial combined 9.9 APOA2 APOB LPA
29 familial lcat deficiency 9.9 APOA2 APOE LCAT
30 autoimmune disease 9.9
31 neurofibromatosis, type i 9.9
32 psoriasis 2 9.9
33 psoriasis 7 9.9
34 psoriasis 11 9.9
35 psoriasis 13 9.9
36 glomerulonephritis 9.9
37 malignant hypertension 9.9
38 psoriasis 9.9
39 fibrillary glomerulonephritis 9.9
40 peripheral vascular disease 9.9 APOB LPA
41 hypercholesterolemia, autosomal dominant, type b 9.8 APOB APOE LDLR
42 homozygous familial hypercholesterolemia 9.8 APOB APOE LDLR
43 cerebrovascular disease 9.8 APOB APOE LDLR
44 aortic atherosclerosis 9.8 APOE LDLR LPA
45 leukodystrophy, hypomyelinating, 3 9.8 APOA2 APOB APOE LPA
46 kidney disease 9.8 APOE LCAT LPA
47 xanthomatosis 9.7 APOB APOE LDLR LPA
48 hyperlipoproteinemia, type iii 9.7 APOB APOE LDLR LPA
49 arteries, anomalies of 9.7 APOB APOE LDLR LPA
50 atherosclerosis susceptibility 9.7 APOB APOE LDLR LPA

Graphical network of the top 20 diseases related to Lipoprotein Glomerulopathy:



Diseases related to Lipoprotein Glomerulopathy

Symptoms & Phenotypes for Lipoprotein Glomerulopathy

Clinical features from OMIM:

611771

Human phenotypes related to Lipoprotein Glomerulopathy:

32
# Description HPO Frequency HPO Source Accession
1 renal insufficiency 32 HP:0000083
2 proteinuria 32 HP:0000093
3 glomerulopathy 32 HP:0100820
4 mesangial hypercellularity 32 HP:0012574

GenomeRNAi Phenotypes related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOB APOE LDLR LPA
2 Increased LDL uptake GR00340-A-1 8.62 APOE LDLR

MGI Mouse Phenotypes related to Lipoprotein Glomerulopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 APOB APOE CLU LCAT LDLR
2 homeostasis/metabolism MP:0005376 9.43 APOA2 APOB APOE CLU LCAT LDLR
3 liver/biliary system MP:0005370 8.92 APOB APOE LCAT LDLR

Drugs & Therapeutics for Lipoprotein Glomerulopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Therapeutic Effect of Immunoadsorption for Patients With Lipoprotein Glomerulopathy Completed NCT00302510 Not Applicable

Search NIH Clinical Center for Lipoprotein Glomerulopathy

Genetic Tests for Lipoprotein Glomerulopathy

Genetic tests related to Lipoprotein Glomerulopathy:

# Genetic test Affiliating Genes
1 Lipoprotein Glomerulopathy 29 APOE

Anatomical Context for Lipoprotein Glomerulopathy

MalaCards organs/tissues related to Lipoprotein Glomerulopathy:

41
Kidney, Endothelial, Brain, Heart, Eye, Monocytes, Skin

Publications for Lipoprotein Glomerulopathy

Articles related to Lipoprotein Glomerulopathy:

(show top 50) (show all 185)
# Title Authors Year
1
The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518Ti19C, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy. ( 29398675 )
2018
2
A case of lipoprotein glomerulopathy with a rare apolipoprotein E isoform combined with neurofibromatosis type I. ( 29356944 )
2018
3
Thermodynamic destabilization and aggregation propensity as the mechanism behind the association of apoE3 mutants and lipoprotein glomerulopathy. ( 30309894 )
2018
4
Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review. ( 30421781 )
2018
5
Correction to: Household Determinants of Liquified Petroleum Gas (LPG) as a Cooking Fuel in South West Cameroon. ( 30315509 )
2018
6
The Mega Conversion Program from Kerosene to LPG in Indonesia: lessons learned and recommendations for future clean cooking energy expansion. ( 30333687 )
2018
7
Induction of hydrogen, hydroxy, and LPG with ethanol in a common SI engine: a comparison of performance and emission characteristics. ( 30506384 )
2018
8
Modeling the potential health benefits of lower household air pollution after a hypothetical liquified petroleum gas (LPG) cookstove intervention. ( 29182949 )
2018
9
Cooking Fuels in Lagos, Nigeria: Factors Associated with Household Choice of Kerosene or Liquefied Petroleum Gas (LPG). ( 29614713 )
2018
10
Enhancing LPG adoption in Ghana (ELAG): a factorial cluster-randomized controlled trial to Enhance LPG Adoption & Sustained use. ( 29866127 )
2018
11
LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies. ( 29954342 )
2018
12
Liquified Petroleum Gas (LPG) Supply and Demand for Cooking in Northern Ghana. ( 30109459 )
2018
13
Experiences with the Mass Distribution of LPG Stoves in Rural Communities of Ghana. ( 30232662 )
2018
14
Household Determinants of Liquified Petroleum Gas (LPG) as a Cooking Fuel in SW Cameroon. ( 30276494 )
2018
15
A Case of Lipoprotein Glomerulopathy with apoE Chicago and apoE (Glu3Lys) Treated with Fenofibrate. ( 28966924 )
2017
16
Predictors and respiratory depositions of airborne endotoxin in homes using biomass fuels and LPG gas for cooking. ( 26956936 )
2017
17
NKT cell activation by Leishmania mexicana LPG: Description of a novel pathway. ( 27523746 )
2017
18
Explosion hazards of LPG-air mixtures in vented enclosure with obstacles. ( 28402895 )
2017
19
Effect of Steam Deactivation Severity of ZSM-5 Additives on LPG Olefins Production in the FCC Process. ( 29065480 )
2017
20
Room temperature LPG resistive sensor based on the use of a few-layer graphene/SnO2 nanocomposite. ( 29594642 )
2017
21
Five-year follow-up of a case of lipoprotein glomerulopathy with APOE Kyoto mutation. ( 28508969 )
2016
22
SPONTANEOUS LIPOPROTEIN GLOMERULOPATHY-LIKE NEPHROPATHY IN A SQUIRREL (SCIURUS VULGARIS). ( 27468047 )
2016
23
Optical fiber LPG biosensor integrated microfluidic chip for ultrasensitive glucose detection. ( 27231643 )
2016
24
Laparoscopic long sleeve pancreaticogastrostomy (LPG): a novel pancreatic anastomosis following central pancreatectomy. ( 27275466 )
2016
25
Discrimination and divergence among Lactobacillus plantarum-group (LPG) isolates with reference to their probiotic functionalities from vegetable origin. ( 27729171 )
2016
26
Macrophage Infiltration into the Glomeruli in Lipoprotein Glomerulopathy. ( 26955632 )
2015
27
LPG Dependence after a Suicide Attempt. ( 25664196 )
2015
28
Detecting Liquefied Petroleum Gas (LPG) at Room Temperature Using ZnSnO3/ZnO Nanowire Piezo-Nanogenerator as Self-Powered Gas Sensor. ( 25915174 )
2015
29
Fire disaster caused by LPG tanker explosion at Lice in Diyarbakır (Turkey): July 21, 2014. ( 25922300 )
2015
30
SnO2 quantum dots decorated on RGO: a superior sensitive, selective and reproducible performance for a H2 and LPG sensor. ( 26108919 )
2015
31
Widely tunable mode-locked fiber laser using carbon nanotube and LPG W-shaped filter. ( 26371928 )
2015
32
Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells. ( 26630499 )
2015
33
Apolipoprotein e mutation and double filtration plasmapheresis therapy on a new chinese patient with lipoprotein glomerulopathy. ( 25300642 )
2014
34
Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice. ( 25183802 )
2014
35
Apolipoprotein E mutations: a comparison between lipoprotein glomerulopathy and type III hyperlipoproteinemia. ( 24570178 )
2014
36
Long-term outcome of kidney transplantation in a patient with coexisting lipoprotein glomerulopathy and fibrillary glomerulonephritis. ( 25852917 )
2014
37
Lipoprotein glomerulopathy: a case report of a rare disease in a Brazilian child. ( 24676620 )
2014
38
Lipoprotein glomerulopathy may provide a key to unlock the puzzles of renal lipidosis. ( 24487366 )
2014
39
Lipoprotein glomerulopathy in China. ( 24165683 )
2014
40
Cost-effective application of thermal protection on LPG road transport tanks for risk reduction due to hot BLEVE incidents. ( 24283673 )
2014
41
Vaccination with Leishmania mexicana LPG induces PD-1 in CD8⁺ and PD-L2 in macrophages thereby suppressing the immune response: a model to assess vaccine efficacy. ( 24462405 )
2014
42
Chemically designed Pt/PPy nano-composite for effective LPG gas sensor. ( 24464341 )
2014
43
A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension. ( 23448537 )
2013
44
Lipoprotein glomerulopathy associated with a mutation in apolipoprotein e. ( 24348079 )
2013
45
A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy. ( 24149834 )
2013
46
A founder haplotype of APOE-Sendai mutation associated with lipoprotein glomerulopathy. ( 23407349 )
2013
47
Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy. ( 23110818 )
2013
48
Topics in lipoprotein glomerulopathy: an overview. ( 24149835 )
2013
49
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation. ( 24025644 )
2013
50
Agarose gel-coated LPG based on two sensing mechanisms for relative humidity measurement. ( 23292379 )
2013

Variations for Lipoprotein Glomerulopathy

UniProtKB/Swiss-Prot genetic disease variations for Lipoprotein Glomerulopathy:

75
# Symbol AA change Variation ID SNP ID
1 APOE p.Arg43Cys VAR_042734 rs121918399
2 APOE p.Arg163Pro VAR_042735 rs121918397

ClinVar genetic disease variations for Lipoprotein Glomerulopathy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APOE NM_000041.3(APOE): c.488G> C (p.Arg163Pro) single nucleotide variant Pathogenic rs121918397 GRCh37 Chromosome 19, 45412041: 45412041
2 APOE NM_000041.3(APOE): c.488G> C (p.Arg163Pro) single nucleotide variant Pathogenic rs121918397 GRCh38 Chromosome 19, 44908784: 44908784
3 APOE NM_000041.3(APOE): c.127C> T (p.Arg43Cys) single nucleotide variant Pathogenic rs121918399 GRCh37 Chromosome 19, 45411100: 45411100
4 APOE NM_000041.3(APOE): c.127C> T (p.Arg43Cys) single nucleotide variant Pathogenic rs121918399 GRCh38 Chromosome 19, 44907843: 44907843

Expression for Lipoprotein Glomerulopathy

Search GEO for disease gene expression data for Lipoprotein Glomerulopathy.

Pathways for Lipoprotein Glomerulopathy

Pathways related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 APOA2 APOB APOE LCAT LDLR LPA
2
Show member pathways
12.17 APOA2 APOB APOE LDLR
3
Show member pathways
11.97 APOA2 APOB APOE LCAT LDLR LPA
4
Show member pathways
11.83 APOB APOE LDLR
5
Show member pathways
11.79 APOA2 APOB APOE LDLR
6
Show member pathways
11.17 APOA2 APOB APOE LCAT LDLR LPA
7 11.09 APOB LPA
8 10.87 APOE LDLR

GO Terms for Lipoprotein Glomerulopathy

Cellular components related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.93 APOA2 APOB APOE CLU LCAT
2 extracellular region GO:0005576 9.93 APOA2 APOB APOE CLU LCAT LPA
3 extracellular space GO:0005615 9.91 APOA2 APOB APOE CLU LCAT
4 endoplasmic reticulum lumen GO:0005788 9.7 APOA2 APOB APOE
5 early endosome GO:0005769 9.67 APOA2 APOB APOE LDLR
6 blood microparticle GO:0072562 9.65 APOA2 APOE CLU
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.5 APOB APOE LDLR
8 endocytic vesicle lumen GO:0071682 9.49 APOB APOE
9 spherical high-density lipoprotein particle GO:0034366 9.43 APOA2 CLU
10 high-density lipoprotein particle GO:0034364 9.43 APOA2 APOE LCAT
11 intermediate-density lipoprotein particle GO:0034363 9.4 APOB APOE
12 very-low-density lipoprotein particle GO:0034361 9.33 APOA2 APOB APOE
13 low-density lipoprotein particle GO:0034362 9.13 APOB APOE LDLR
14 chylomicron GO:0042627 8.8 APOA2 APOB APOE

Biological processes related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.95 APOB APOE CLU LCAT LDLR LPA
2 positive regulation of gene expression GO:0010628 9.86 APOB CLU LDLR
3 post-translational protein modification GO:0043687 9.86 APOA2 APOB APOE
4 steroid metabolic process GO:0008202 9.86 APOB APOE LCAT LDLR
5 cellular protein metabolic process GO:0044267 9.85 APOA2 APOB APOE
6 receptor-mediated endocytosis GO:0006898 9.83 APOB APOE LDLR
7 lipid transport GO:0006869 9.83 APOA2 APOB APOE LDLR LPA
8 retinoid metabolic process GO:0001523 9.77 APOA2 APOB APOE
9 cholesterol efflux GO:0033344 9.74 APOA2 APOB APOE
10 high-density lipoprotein particle remodeling GO:0034375 9.72 APOA2 APOE LCAT
11 chylomicron assembly GO:0034378 9.71 APOA2 APOB APOE
12 high-density lipoprotein particle clearance GO:0034384 9.7 APOA2 APOE LDLR
13 chylomicron remnant clearance GO:0034382 9.69 APOB APOE LDLR
14 triglyceride metabolic process GO:0006641 9.68 APOA2 APOE
15 long-term memory GO:0007616 9.68 APOE LDLR
16 phosphatidylcholine biosynthetic process GO:0006656 9.68 APOA2 LCAT
17 triglyceride catabolic process GO:0019433 9.67 APOB APOE
18 positive regulation of endocytosis GO:0045807 9.67 APOE LDLR
19 chylomicron remodeling GO:0034371 9.67 APOA2 APOB APOE
20 cholesterol transport GO:0030301 9.67 APOA2 APOB LCAT LDLR
21 low-density lipoprotein particle clearance GO:0034383 9.66 APOB LDLR
22 artery morphogenesis GO:0048844 9.65 APOB APOE
23 regulation of cholesterol metabolic process GO:0090181 9.65 APOE LDLR
24 high-density lipoprotein particle assembly GO:0034380 9.65 APOA2 APOE
25 cholesterol homeostasis GO:0042632 9.65 APOA2 APOB APOE LCAT LDLR
26 phospholipid efflux GO:0033700 9.64 APOA2 APOE
27 regulation of protein metabolic process GO:0051246 9.64 APOE LDLR
28 negative regulation of amyloid-beta formation GO:1902430 9.63 APOE CLU
29 positive regulation of cholesterol esterification GO:0010873 9.63 APOA2 APOE
30 lipoprotein biosynthetic process GO:0042158 9.63 APOB APOE LCAT
31 very-low-density lipoprotein particle remodeling GO:0034372 9.62 APOE LCAT
32 very-low-density lipoprotein particle clearance GO:0034447 9.62 APOB APOE
33 lipoprotein metabolic process GO:0042157 9.62 APOA2 APOB APOE LDLR
34 protein import GO:0017038 9.61 APOE CLU
35 negative regulation of amyloid fibril formation GO:1905907 9.61 CLU LDLR
36 positive regulation of amyloid fibril formation GO:1905908 9.6 APOE CLU
37 regulation of amyloid-beta clearance GO:1900221 9.58 APOE CLU
38 response to caloric restriction GO:0061771 9.58 APOE LDLR
39 lipoprotein catabolic process GO:0042159 9.58 APOB APOE LDLR
40 cholesterol metabolic process GO:0008203 9.55 APOA2 APOB APOE LCAT LDLR
41 reverse cholesterol transport GO:0043691 9.26 APOA2 APOE CLU LCAT
42 low-density lipoprotein particle remodeling GO:0034374 8.92 APOA2 APOB APOE LPA

Molecular functions related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.63 APOA2 APOB APOE
2 heparin binding GO:0008201 9.58 APOB APOE LPA
3 phospholipid binding GO:0005543 9.54 APOA2 APOB APOE
4 cholesterol binding GO:0015485 9.48 APOA2 APOE
5 tau protein binding GO:0048156 9.43 APOE CLU
6 amyloid-beta binding GO:0001540 9.43 APOE CLU LDLR
7 lipid transporter activity GO:0005319 9.33 APOA2 APOB APOE
8 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.32 APOA2 APOE
9 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CLU
10 cholesterol transporter activity GO:0017127 8.8 APOA2 APOB APOE

Sources for Lipoprotein Glomerulopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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