LPG
MCID: LPP002
MIFTS: 45

Lipoprotein Glomerulopathy (LPG)

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Lipoprotein Glomerulopathy

MalaCards integrated aliases for Lipoprotein Glomerulopathy:

Name: Lipoprotein Glomerulopathy 58 60 76 38 30 13 6 41 74
Lpg 58 60 76

Characteristics:

Orphanet epidemiological data:

60
lipoprotein glomerulopathy
Inheritance: Autosomal dominant; Age of onset: All ages;

Classifications:



External Ids:

OMIM 58 611771
KEGG 38 H00887
ICD10 via Orphanet 35 N07.8
UMLS via Orphanet 75 C2673196
Orphanet 60 ORPHA329481
MedGen 43 C2673196
UMLS 74 C2673196

Summaries for Lipoprotein Glomerulopathy

OMIM : 58 Lipoprotein glomerulopathy is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries (Saito et al., 2006). It mainly affects people of Japanese and Chinese origin; in these populations, it is associated with mutations in the gene that encodes apolipoprotein E (APOE; 107741). The disorder had rarely been described in Caucasians. (611771)

MalaCards based summary : Lipoprotein Glomerulopathy, also known as lpg, is related to nephrotic syndrome and burns. An important gene associated with Lipoprotein Glomerulopathy is APOE (Apolipoprotein E), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Affiliated tissues include kidney, heart and monocytes, and related phenotypes are renal insufficiency and proteinuria

UniProtKB/Swiss-Prot : 76 Lipoprotein glomerulopathy: Uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries.

Related Diseases for Lipoprotein Glomerulopathy

Diseases related to Lipoprotein Glomerulopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 nephrotic syndrome 10.4
2 burns 10.3
3 streptococcal group a invasive disease 10.3
4 xanthoma disseminatum 10.2 APOB APOE
5 hyperlipoproteinemia, type v 10.2 APOB APOE
6 carney complex, type 1 10.2
7 caronte 10.2
8 ischemic heart disease 10.2 APOB APOE
9 hypertriglyceridemia, familial 10.1 APOB APOE
10 hypobetalipoproteinemia, familial, 2 10.1 APOB LPA
11 fetal macrosomia 10.1 APOB LCAT
12 coronary stenosis 10.1 APOB APOE
13 amyloidosis aa 10.1 LCAT LPA
14 exfoliation syndrome 10.0 APOE CLU
15 hyperlipoproteinemia, type iv 10.0 APOA2 APOB
16 acute insulin response 10.0
17 hearing loss, noise-induced 10.0
18 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
19 localized scleroderma 10.0
20 niemann-pick disease, type b 10.0 LCAT LPA
21 gallbladder disease 10.0 APOB APOE
22 fish-eye disease 10.0 APOA2 LCAT
23 pick disease of brain 10.0 APOE CLU
24 huntington disease-like 1 10.0 APOB APOE LPA
25 carotid artery disease 9.9 APOB APOE LPA
26 arteriosclerosis 9.9 APOB APOE LPA
27 autoimmune disease 9.9
28 neurofibromatosis, type i 9.9
29 neurofibromatosis, type iv, of riccardi 9.9
30 psoriasis 7 9.9
31 psoriasis 11 9.9
32 psoriasis 13 9.9
33 familial nephrotic syndrome 9.9
34 glomerulonephritis 9.9
35 malignant hypertension 9.9
36 psoriasis 9.9
37 fibrillary glomerulonephritis 9.9
38 stroke, ischemic 9.9 APOB APOE LPA
39 amyloidosis, familial visceral 9.9 APOA2 LPA
40 smith-lemli-opitz syndrome 9.9 APOE LDLR
41 schnyder corneal dystrophy 9.9 APOA2 APOB APOE
42 hyperlipidemia, familial combined 9.8 APOA2 APOB LPA
43 familial lcat deficiency 9.8 APOA2 APOE LCAT
44 peripheral vascular disease 9.8 APOB LPA
45 hypercholesterolemia, autosomal dominant, type b 9.8 APOB APOE LDLR
46 homozygous familial hypercholesterolemia 9.7 APOB APOE LDLR
47 cerebrovascular disease 9.7 APOB APOE LDLR
48 aortic atherosclerosis 9.7 APOE LDLR LPA
49 leukodystrophy, hypomyelinating, 3 9.6 APOA2 APOB APOE LPA
50 kidney disease 9.6 APOE LCAT LPA

Graphical network of the top 20 diseases related to Lipoprotein Glomerulopathy:



Diseases related to Lipoprotein Glomerulopathy

Symptoms & Phenotypes for Lipoprotein Glomerulopathy

Human phenotypes related to Lipoprotein Glomerulopathy:

33
# Description HPO Frequency HPO Source Accession
1 renal insufficiency 33 HP:0000083
2 proteinuria 33 HP:0000093
3 glomerulopathy 33 HP:0100820
4 mesangial hypercellularity 33 HP:0012574

Clinical features from OMIM:

611771

GenomeRNAi Phenotypes related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.26 APOB APOE LDLR LPA
2 Increased LDL uptake GR00340-A-1 8.62 APOE LDLR

MGI Mouse Phenotypes related to Lipoprotein Glomerulopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 APOB APOE CLU LCAT LDLR
2 homeostasis/metabolism MP:0005376 9.63 APOA2 APOB APOE CLU LCAT LDLR
3 liver/biliary system MP:0005370 9.26 APOB APOE LCAT LDLR
4 pigmentation MP:0001186 8.8 APOB APOE LDLR

Drugs & Therapeutics for Lipoprotein Glomerulopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Therapeutic Effect of Immunoadsorption for Patients With Lipoprotein Glomerulopathy Completed NCT00302510 Not Applicable

Search NIH Clinical Center for Lipoprotein Glomerulopathy

Genetic Tests for Lipoprotein Glomerulopathy

Genetic tests related to Lipoprotein Glomerulopathy:

# Genetic test Affiliating Genes
1 Lipoprotein Glomerulopathy 30 APOE

Anatomical Context for Lipoprotein Glomerulopathy

MalaCards organs/tissues related to Lipoprotein Glomerulopathy:

42
Kidney, Heart, Monocytes, Skin, Endothelial, T Cells, Nk Cells

Publications for Lipoprotein Glomerulopathy

Articles related to Lipoprotein Glomerulopathy:

(show top 50) (show all 203)
# Title Authors Year
1
A novel apolipoprotein E mutation (p.Arg150Cys) in a Chinese patient with lipoprotein glomerulopathy. ( 30614865 )
2019
2
A young Chinese man with nephrotic syndrome due to lipoprotein glomerulopathy. ( 30685233 )
2019
3
Unusual Case of Lipoprotein Glomerulopathy First Diagnosed in a Protocol Kidney Allograft Biopsy. ( 30775634 )
2019
4
A novel apolipoprotein E mutation caused by a five amino acid deletion in a Chinese family with lipoprotein glomerulopathy: a case report. ( 31092271 )
2019
5
LPG Cars in a Car Park Environment-How to Make It Safe. ( 30909653 )
2019
6
Combining carbon pricing with LPG subsidy for promoting preservation and restoration of Uttarakhand forests. ( 30738298 )
2019
7
Using photovoice methods as a community-based participatory research tool to advance uptake of clean cooking and improve health: The LPG adoption in Cameroon evaluation studies. ( 30875542 )
2019
8
Environmental and enviroeconomic assessment of an LPG fueled SI engine at partial load. ( 30955968 )
2019
9
Promoting LPG usage during pregnancy: A pilot study in rural Maharashtra, India. ( 30981912 )
2019
10
Resistive room temperature LPG sensor based on a graphene/CdO nanocomposite. ( 30627873 )
2019
11
Induction of hydrogen, hydroxy, and LPG with ethanol in a common SI engine: a comparison of performance and emission characteristics. ( 30506384 )
2019
12
A case of lipoprotein glomerulopathy with a rare apolipoprotein E isoform combined with neurofibromatosis type I. ( 29356944 )
2018
13
The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518T>C, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy. ( 29398675 )
2018
14
Thermodynamic destabilization and aggregation propensity as the mechanism behind the association of apoE3 mutants and lipoprotein glomerulopathy. ( 30309894 )
2018
15
Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review. ( 30421781 )
2018
16
Premixed LPG + Air Combustion in a Bubbling FBC with Variable Content of Solid Particles in the Bubbles. ( 30574013 )
2018
17
The Mega Conversion Program from Kerosene to LPG in Indonesia: lessons learned and recommendations for future clean cooking energy expansion. ( 30333687 )
2018
18
Correction to: Household Determinants of Liquified Petroleum Gas (LPG) as a Cooking Fuel in South West Cameroon. ( 30315509 )
2018
19
Household Determinants of Liquified Petroleum Gas (LPG) as a Cooking Fuel in South West Cameroon. ( 30276494 )
2018
20
Experiences with the Mass Distribution of LPG Stoves in Rural Communities of Ghana. ( 30232662 )
2018
21
Liquified Petroleum Gas (LPG) Supply and Demand for Cooking in Northern Ghana. ( 30109459 )
2018
22
LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies. ( 29954342 )
2018
23
Enhancing LPG adoption in Ghana (ELAG): a factorial cluster-randomized controlled trial to Enhance LPG Adoption & Sustained use. ( 29866127 )
2018
24
Cooking Fuels in Lagos, Nigeria: Factors Associated with Household Choice of Kerosene or Liquefied Petroleum Gas (LPG). ( 29614713 )
2018
25
Modeling the potential health benefits of lower household air pollution after a hypothetical liquified petroleum gas (LPG) cookstove intervention. ( 29182949 )
2018
26
A Case of Lipoprotein Glomerulopathy with apoE Chicago and apoE (Glu3Lys) Treated with Fenofibrate. ( 28966924 )
2017
27
NKT cell activation by Leishmania mexicana LPG: Description of a novel pathway. ( 27523746 )
2017
28
Room temperature LPG resistive sensor based on the use of a few-layer graphene/SnO2 nanocomposite. ( 29594642 )
2017
29
Effect of Steam Deactivation Severity of ZSM-5 Additives on LPG Olefins Production in the FCC Process. ( 29065480 )
2017
30
Explosion hazards of LPG-air mixtures in vented enclosure with obstacles. ( 28402895 )
2017
31
Predictors and respiratory depositions of airborne endotoxin in homes using biomass fuels and LPG gas for cooking. ( 26956936 )
2017
32
SPONTANEOUS LIPOPROTEIN GLOMERULOPATHY-LIKE NEPHROPATHY IN A SQUIRREL (SCIURUS VULGARIS). ( 27468047 )
2016
33
Five-year follow-up of a case of lipoprotein glomerulopathy with APOE Kyoto mutation. ( 28508969 )
2016
34
Discrimination and divergence among Lactobacillus plantarum-group (LPG) isolates with reference to their probiotic functionalities from vegetable origin. ( 27729171 )
2016
35
Laparoscopic long sleeve pancreaticogastrostomy (LPG): a novel pancreatic anastomosis following central pancreatectomy. ( 27275466 )
2016
36
Optical fiber LPG biosensor integrated microfluidic chip for ultrasensitive glucose detection. ( 27231643 )
2016
37
Macrophage Infiltration into the Glomeruli in Lipoprotein Glomerulopathy. ( 26955632 )
2015
38
Detecting Liquefied Petroleum Gas (LPG) at Room Temperature Using ZnSnO3/ZnO Nanowire Piezo-Nanogenerator as Self-Powered Gas Sensor. ( 25915174 )
2015
39
Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells. ( 26630499 )
2015
40
Widely tunable mode-locked fiber laser using carbon nanotube and LPG W-shaped filter. ( 26371928 )
2015
41
SnO2 quantum dots decorated on RGO: a superior sensitive, selective and reproducible performance for a H2 and LPG sensor. ( 26108919 )
2015
42
Fire disaster caused by LPG tanker explosion at Lice in Diyarbakır (Turkey): July 21, 2014. ( 25922300 )
2015
43
LPG Dependence after a Suicide Attempt. ( 25664196 )
2015
44
Long-term outcome of kidney transplantation in a patient with coexisting lipoprotein glomerulopathy and fibrillary glomerulonephritis. ( 25852917 )
2014
45
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation. ( 24025644 )
2014
46
A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy. ( 24149834 )
2014
47
Topics in lipoprotein glomerulopathy: an overview. ( 24149835 )
2014
48
Lipoprotein glomerulopathy in China. ( 24165683 )
2014
49
Lipoprotein glomerulopathy may provide a key to unlock the puzzles of renal lipidosis. ( 24487366 )
2014
50
Apolipoprotein E mutations: a comparison between lipoprotein glomerulopathy and type III hyperlipoproteinemia. ( 24570178 )
2014

Variations for Lipoprotein Glomerulopathy

UniProtKB/Swiss-Prot genetic disease variations for Lipoprotein Glomerulopathy:

76
# Symbol AA change Variation ID SNP ID
1 APOE p.Arg43Cys VAR_042734 rs121918399
2 APOE p.Arg163Pro VAR_042735 rs121918397

ClinVar genetic disease variations for Lipoprotein Glomerulopathy:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APOE NM_000041.3(APOE): c.488G> C (p.Arg163Pro) single nucleotide variant Pathogenic rs121918397 GRCh37 Chromosome 19, 45412041: 45412041
2 APOE NM_000041.3(APOE): c.488G> C (p.Arg163Pro) single nucleotide variant Pathogenic rs121918397 GRCh38 Chromosome 19, 44908784: 44908784
3 APOE NM_000041.3(APOE): c.127C> T (p.Arg43Cys) single nucleotide variant Pathogenic rs121918399 GRCh37 Chromosome 19, 45411100: 45411100
4 APOE NM_000041.3(APOE): c.127C> T (p.Arg43Cys) single nucleotide variant Pathogenic rs121918399 GRCh38 Chromosome 19, 44907843: 44907843

Expression for Lipoprotein Glomerulopathy

Search GEO for disease gene expression data for Lipoprotein Glomerulopathy.

Pathways for Lipoprotein Glomerulopathy

Pathways related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 APOA2 APOB APOE LCAT LDLR LPA
2
Show member pathways
12.16 APOA2 APOB APOE LDLR
3
Show member pathways
11.97 APOA2 APOB APOE LCAT LDLR LPA
4
Show member pathways
11.83 APOB APOE LDLR
5
Show member pathways
11.79 APOA2 APOB APOE LDLR
6
Show member pathways
11.17 APOA2 APOB APOE LCAT LDLR LPA
7 11.09 APOB LPA
8 10.87 APOE LDLR

GO Terms for Lipoprotein Glomerulopathy

Cellular components related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.93 APOA2 APOB APOE CLU LCAT
2 extracellular region GO:0005576 9.93 APOA2 APOB APOE CLU LCAT LPA
3 extracellular space GO:0005615 9.91 APOA2 APOB APOE CLU LCAT
4 endoplasmic reticulum lumen GO:0005788 9.7 APOA2 APOB APOE
5 early endosome GO:0005769 9.67 APOA2 APOB APOE LDLR
6 blood microparticle GO:0072562 9.65 APOA2 APOE CLU
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.5 APOB APOE LDLR
8 endocytic vesicle lumen GO:0071682 9.49 APOB APOE
9 spherical high-density lipoprotein particle GO:0034366 9.43 APOA2 CLU
10 high-density lipoprotein particle GO:0034364 9.43 APOA2 APOE LCAT
11 intermediate-density lipoprotein particle GO:0034363 9.4 APOB APOE
12 very-low-density lipoprotein particle GO:0034361 9.33 APOA2 APOB APOE
13 low-density lipoprotein particle GO:0034362 9.13 APOB APOE LDLR
14 chylomicron GO:0042627 8.8 APOA2 APOB APOE

Biological processes related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.95 APOB APOE CLU LCAT LDLR LPA
2 positive regulation of gene expression GO:0010628 9.86 APOB CLU LDLR
3 post-translational protein modification GO:0043687 9.86 APOA2 APOB APOE
4 steroid metabolic process GO:0008202 9.86 APOB APOE LCAT LDLR
5 cellular protein metabolic process GO:0044267 9.85 APOA2 APOB APOE
6 receptor-mediated endocytosis GO:0006898 9.83 APOB APOE LDLR
7 lipid transport GO:0006869 9.83 APOA2 APOB APOE LDLR LPA
8 retinoid metabolic process GO:0001523 9.77 APOA2 APOB APOE
9 cholesterol efflux GO:0033344 9.74 APOA2 APOB APOE
10 high-density lipoprotein particle remodeling GO:0034375 9.72 APOA2 APOE LCAT
11 chylomicron assembly GO:0034378 9.71 APOA2 APOB APOE
12 high-density lipoprotein particle clearance GO:0034384 9.7 APOA2 APOE LDLR
13 chylomicron remnant clearance GO:0034382 9.69 APOB APOE LDLR
14 triglyceride metabolic process GO:0006641 9.68 APOA2 APOE
15 long-term memory GO:0007616 9.68 APOE LDLR
16 phosphatidylcholine biosynthetic process GO:0006656 9.68 APOA2 LCAT
17 triglyceride catabolic process GO:0019433 9.67 APOB APOE
18 chylomicron remodeling GO:0034371 9.67 APOA2 APOB APOE
19 cholesterol transport GO:0030301 9.67 APOA2 APOB LCAT LDLR
20 low-density lipoprotein particle clearance GO:0034383 9.66 APOB LDLR
21 artery morphogenesis GO:0048844 9.65 APOB APOE
22 regulation of cholesterol metabolic process GO:0090181 9.65 APOE LDLR
23 high-density lipoprotein particle assembly GO:0034380 9.65 APOA2 APOE
24 cholesterol homeostasis GO:0042632 9.65 APOA2 APOB APOE LCAT LDLR
25 phospholipid efflux GO:0033700 9.64 APOA2 APOE
26 regulation of protein metabolic process GO:0051246 9.64 APOE LDLR
27 negative regulation of amyloid-beta formation GO:1902430 9.63 APOE CLU
28 positive regulation of cholesterol esterification GO:0010873 9.63 APOA2 APOE
29 lipoprotein biosynthetic process GO:0042158 9.63 APOB APOE LCAT
30 very-low-density lipoprotein particle remodeling GO:0034372 9.62 APOE LCAT
31 very-low-density lipoprotein particle clearance GO:0034447 9.62 APOB APOE
32 lipoprotein metabolic process GO:0042157 9.62 APOA2 APOB APOE LDLR
33 protein import GO:0017038 9.61 APOE CLU
34 negative regulation of amyloid fibril formation GO:1905907 9.61 CLU LDLR
35 positive regulation of amyloid fibril formation GO:1905908 9.6 APOE CLU
36 regulation of amyloid-beta clearance GO:1900221 9.58 APOE CLU
37 response to caloric restriction GO:0061771 9.58 APOE LDLR
38 lipoprotein catabolic process GO:0042159 9.58 APOB APOE LDLR
39 cholesterol metabolic process GO:0008203 9.55 APOA2 APOB APOE LCAT LDLR
40 positive regulation of endocytosis GO:0045807 9.36 APOE
41 reverse cholesterol transport GO:0043691 9.26 APOA2 APOE CLU LCAT
42 low-density lipoprotein particle remodeling GO:0034374 8.92 APOA2 APOB APOE LPA

Molecular functions related to Lipoprotein Glomerulopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.58 APOB APOE LPA
2 phospholipid binding GO:0005543 9.54 APOA2 APOB APOE
3 cholesterol binding GO:0015485 9.48 APOA2 APOE
4 lipid binding GO:0008289 9.46 APOA2 APOE
5 tau protein binding GO:0048156 9.43 APOE CLU
6 amyloid-beta binding GO:0001540 9.43 APOE CLU LDLR
7 lipid transporter activity GO:0005319 9.33 APOA2 APOB APOE
8 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.32 APOA2 APOE
9 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CLU
10 cholesterol transporter activity GO:0017127 8.8 APOA2 APOB APOE

Sources for Lipoprotein Glomerulopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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