Aliases & Classifications for Liposarcoma

MalaCards integrated aliases for Liposarcoma:

Name: Liposarcoma 12 76 53 55 44 15 73

Classifications:



Summaries for Liposarcoma

NIH Rare Diseases : 53 Liposarcoma is a tumor that arises from fat tissue. This tumor often occurs in the thigh, legs, behind the knee, or in the abdomen, but it can be found in other parts of the body, in the retroperitoneum; and, less often, in the head and neck area. Their primary occurrence in the skin is rare. Because a liposarcoma may grow into surrounding tissues or organs, it is considered a malignant tumor. The World Health Organization classification of soft tissue tumors recognizes 5 types of liposarcomas: Well differentiated, which includes the adipocytic, sclerosing, and inflammatory subtypes; dedifferentiated; myxoid; round cell; and pleomorphic. Most patients with liposarcoma have no symptoms until the tumor is large and invades the neighboring organs or tissues, causing tenderness, pain, or functional problems. Although surgical removal of the tumor is the curative treatment, some patients may benefit from chemotherapy and radiation. Most patients with liposarcoma have no symptoms until the tumor is large and impinges on neighboring structures, causing tenderness, pain, or functional disturbances. In the retroperitoneal area, where liposarcoma is detected at a late stage, the tumor may grow to a substantial size, weighing several pounds at the time of diagnosis. In general, liposarcoma grows silently, and the patient's estimation of the clinical duration is often unreliable. The patient eventually becomes aware of a swelling or a mass and reports this finding to the physician. Patients may report the following: Associated episode of trauma to the region containing the mass Painful swelling (occurs in one third of cases for as long as 6 mo) Decreased function (ie, range of motion) Numbness Enlargement of varicose veins Fatigue Abdominal pain Weight loss Nausea Vomiting 

MalaCards based summary : Liposarcoma is related to pleomorphic liposarcoma and dedifferentiated liposarcoma. An important gene associated with Liposarcoma is FUS (FUS RNA Binding Protein), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include adipocyte, t cells and bone, and related phenotypes are abnormality of the kidney and subcutaneous nodule

Disease Ontology : 12 A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum.

Wikipedia : 76 Liposarcoma is a cancer that arises in fat cells in deep soft tissue, such as that inside the thigh or... more...

Related Diseases for Liposarcoma

Diseases in the Liposarcoma family:

Adult Liposarcoma Inflammatory Liposarcoma

Diseases related to Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 304)
# Related Disease Score Top Affiliating Genes
1 pleomorphic liposarcoma 33.4 CDKN2A DES MDM2 VIM
2 dedifferentiated liposarcoma 32.8 CDK4 CDKN2A DES HMGA2 MDM2 TP53
3 well-differentiated liposarcoma 32.8 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
4 myxoid liposarcoma 32.7 CDK4 DDIT3 EWSR1 FUS HMGA2 LRP1
5 sclerosing liposarcoma 32.3 CD34 FUS MB MDM2 TP53
6 spindle cell liposarcoma 32.2 CALB2 CD34 CDK4 DDIT3 MDM2
7 mixed liposarcoma 32.1 CD34 CDK4 DDIT3 FUS MB MDM2
8 atypical lipomatous tumor 31.6 CDK4 CDKN2A FUS HMGA2 MDM2 TSPAN31
9 myxofibrosarcoma 30.8 DES FUS
10 soft tissue sarcoma 30.8 EWSR1 MDM2 TP53
11 li-fraumeni syndrome 30.5 CDKN2A MDM2 TP53
12 angiolipoma 30.5 DES VIM
13 malignant fibroxanthoma 30.5 CDK4 DES MDM2 VIM
14 hemangiopericytoma, malignant 30.5 DES MDM2 VIM
15 conventional central osteosarcoma 30.4 EWSR1 MDM2
16 fibrous histiocytoma 30.4 DES EWSR1 FUS VIM
17 retroperitoneal fibrosis 30.3 MDM2 VIM
18 chondroid lipoma 30.2 CDK4 DDIT3 FUS MDM2
19 mesenchymoma 30.1 DES HMGA2 MB MDM2
20 spindle cell lipoma 30.1 CDK4 DES MDM2 VIM
21 inflammatory myofibroblastic tumor 29.8 DES MDM2 TP53 VIM
22 retinoblastoma 29.8 CDK4 CDKN2A MDM2 TP53
23 pleomorphic adenoma 29.8 HMGA2 MDM2 TP53 VIM
24 malignant peripheral nerve sheath tumor 29.7 CDK4 CDKN2A MDM2 TP53 VIM
25 infiltrating lipoma 29.6 CD34 CDK4 HMGA2 MDM2
26 leiomyoma 29.3 CD34 DES HMGA2 VIM
27 leiomyosarcoma 29.3 CDK4 DES MB MDM2 TP53 VIM
28 malignant mesenchymoma 29.1 CDK4 DES EWSR1 MB MDM2 TP53
29 sarcoma, synovial 29.0 CALB2 DES HMGA2 MDM2 VIM
30 histiocytoma 28.7 CDK4 EWSR1 FUS MB MDM2 TP53
31 pleomorphic lipoma 28.6 CALB2 CD34 CDK4 DDIT3 HMGA2 MDM2
32 rhabdomyosarcoma 28.5 CDK4 DES EWSR1 MB MDM2 TP53
33 mediastinum liposarcoma 12.2
34 larynx liposarcoma 12.1
35 kidney liposarcoma 12.1
36 retroperitoneal liposarcoma 12.1
37 gastric liposarcoma 12.0
38 cellular myxoid liposarcoma 12.0
39 inflammatory liposarcoma 12.0
40 liposarcoma of the ovary 12.0
41 breast liposarcoma 12.0
42 myxoid liposarcoma of the ovary 12.0
43 esophagus liposarcoma 12.0
44 liposarcoma of bone 11.9
45 vulvar liposarcoma 11.9
46 cutaneous liposarcoma 11.8
47 adult liposarcoma 11.8
48 pediatric liposarcoma 11.8
49 fibroblastic liposarcoma 11.8
50 intracranial liposarcoma 11.8

Graphical network of the top 20 diseases related to Liposarcoma:



Diseases related to Liposarcoma

Symptoms & Phenotypes for Liposarcoma

Human phenotypes related to Liposarcoma:

32 (show all 9)
# Description HPO Frequency HPO Source Accession
1 abnormality of the kidney 32 occasional (7.5%) HP:0000077
2 subcutaneous nodule 32 hallmark (90%) HP:0001482
3 weight loss 32 occasional (7.5%) HP:0001824
4 nausea and vomiting 32 occasional (7.5%) HP:0002017
5 abdominal pain 32 occasional (7.5%) HP:0002027
6 varicose veins 32 occasional (7.5%) HP:0002619
7 paresthesia 32 occasional (7.5%) HP:0003401
8 fatigue 32 occasional (7.5%) HP:0012378
9 sarcoma 32 hallmark (90%) HP:0100242

GenomeRNAi Phenotypes related to Liposarcoma according to GeneCards Suite gene sharing:

26 (show all 26)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.12 VIM
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.12 FUS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.12 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.12 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.12 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.12 VIM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.12 FUS
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.12 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.12 VIM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.12 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.12 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.12 TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.12 VIM FUS PPARG TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.12 FUS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.12 VIM
16 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.12 FUS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.12 VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.12 TP53
19 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.12 PPARG
20 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.12 FUS TP53
21 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.12 FUS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.12 VIM
23 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.12 FUS
24 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.12 FUS
25 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.12 VIM
26 Reduced mammosphere formation GR00396-S 9.17 CD34 CDK4 DDIT3 DES MDM2 PPARG

MGI Mouse Phenotypes related to Liposarcoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 DDIT3 CD34 CDK4 DES LRP1 CDKN2A
2 behavior/neurological MP:0005386 10.24 CALB2 DDIT3 DES CDK4 LRP1 CDKN2A
3 cardiovascular system MP:0005385 10.22 DDIT3 CDK4 DES LRP1 CDKN2A MB
4 hematopoietic system MP:0005397 10.18 DDIT3 CD34 CDK4 LRP1 CDKN2A MB
5 homeostasis/metabolism MP:0005376 10.18 CD34 DDIT3 DES CDK4 LRP1 CDKN2A
6 embryo MP:0005380 10.09 CDK4 LRP1 CDKN2A MB TP53 MDM2
7 immune system MP:0005387 10.02 CDKN2A CD34 DDIT3 CDK4 LRP1 TP53
8 integument MP:0010771 9.86 CDKN2A CD34 CDK4 LRP1 TP53 MDM2
9 liver/biliary system MP:0005370 9.76 DDIT3 CDK4 LRP1 CDKN2A TP53 MDM2
10 muscle MP:0005369 9.61 CDK4 DES LRP1 CDKN2A MB MDM2
11 neoplasm MP:0002006 9.17 CD34 DDIT3 CDK4 CDKN2A TP53 MDM2

Drugs & Therapeutics for Liposarcoma

Drugs for Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 130)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1,Not Applicable 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 51-75-2 4033
4
Dacarbazine Approved, Investigational Phase 3,Phase 2 4342-03-4 5351166
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
6
Trabectedin Approved, Investigational Phase 3,Phase 2,Phase 1 114899-77-3 108150
7
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
8
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
9
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
10
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 2019 457193
11
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
12
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
13
Docetaxel Approved, Investigational Phase 3,Phase 2 114977-28-5 148124
14
Gemcitabine Approved Phase 3,Phase 2,Phase 1 95058-81-4 60750
15
Cyproheptadine Approved Phase 3 129-03-3 2913
16
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
17
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1,Not Applicable 31703
18 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
19 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
20 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable
21 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable
22
Isophosphamide mustard Phase 3,Phase 2,Phase 1,Not Applicable 0
23 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
24 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
25 Antirheumatic Agents Phase 3,Phase 2,Phase 1
26 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
27 Pharmaceutical Solutions Phase 3
28 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
29 Etoposide phosphate Phase 3,Phase 2
30 Antimitotic Agents Phase 3,Phase 2
31 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
32 Antimetabolites Phase 3,Phase 2,Phase 1
33 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
34 Antiviral Agents Phase 3,Phase 2,Phase 1,Not Applicable
35 Gastrointestinal Agents Phase 3,Phase 2
36 Anti-Allergic Agents Phase 3
37 Antipruritics Phase 3
38 Dermatologic Agents Phase 3
39 Histamine Antagonists Phase 3
40 Histamine H1 Antagonists Phase 3
41
Histamine Phosphate Phase 3 51-74-1 65513
42 Neurotransmitter Agents Phase 3
43 Serotonin Agents Phase 3
44 Serotonin Antagonists Phase 3
45
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
46
Everolimus Approved Phase 2,Phase 1 159351-69-6 6442177
47
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
48
Sirolimus Approved, Investigational Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
49
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
50
Palbociclib Approved, Investigational Phase 2,Phase 1 571190-30-2 11431660 5005498 5330286

Interventional clinical trials:

(show top 50) (show all 120)
# Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 A Study of Trabectedin or Dacarbazine for the Treatment of Patients With Advanced Liposarcoma or Leiomyosarcoma Completed NCT01343277 Phase 3 Trabectedin;Dacarbazine
3 A Study of Trabectedin (YONDELIS) in Patients With Locally Advanced or Metastatic Liposarcoma or Leiomyosarcoma Completed NCT01692678 Phase 3 Trabectedin;Dacarbazine
4 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
6 Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
8 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
9 Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
10 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
11 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
12 Selinexor in Advanced Liposarcoma Recruiting NCT02606461 Phase 2, Phase 3 Selinexor;Placebo
13 Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy Recruiting NCT01710176 Phase 3 epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3);gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8);trabectedin 1.3 mg/m2;high-dose ifosfamide 14 g/m2, given in in 14 days;etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3);gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)
14 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
15 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma Recruiting NCT01344018 Phase 3
16 A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma Active, not recruiting NCT02451943 Phase 3 Olaratumab;Doxorubicin;Placebo
17 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
18 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
19 Brostallicin Clinical Trial for Myxoid Liposarcoma Unknown status NCT00633165 Phase 2 Brostallicin
20 Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial Unknown status NCT01692496 Phase 2 Pazopanib
21 Trial of Nilotinib and Adriamycin as Treatment in Liposarcomas and Leiomyosarcomas of Retroperitoneum Unknown status NCT02587169 Phase 1, Phase 2 Nilotinib-adriamycin
22 Sirolimus and Cyclophosphamide in Metastatic or Unresectable Myxoid Liposarcoma and Chondrosarcoma Unknown status NCT02821507 Phase 2 sirolimus and cyclophosphamide
23 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
24 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
25 Study of Pazopanib in the Treatment of Surgically Unresectable or Metastatic Liposarcoma Completed NCT01506596 Phase 2 pazopanib
26 PD0332991 (Palbociclib) in Patients With Advanced or Metastatic Liposarcoma Completed NCT01209598 Phase 2 Palbociclib 200mg;Palbociclib 125mg
27 Safety and Efficacy Study of Trabectedin for the Treatment of Localized Myxoid / Round Cell Liposarcoma Completed NCT00579501 Phase 2 Trabectedin;Dexamethasone
28 Rosiglitazone in Treating Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
29 Troglitazone in Treating Patients With Liposarcoma Completed NCT00003058 Phase 2 troglitazone
30 A Study to Assess Treatment With 2 Different Dosing Schedules of Trabectidin Administered to Patients With Advanced Cancer Completed NCT00060944 Phase 2 Yondelis;Yondelis;Dexamethasone;Dexamethasone
31 Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma Completed NCT00400569 Phase 2 Sunitinib Malate (SU011248)
32 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2 RG1507
33 Study of Doxorubicin and Trabectedin in First Line Treatment on Patients With Metastatic Leiomyosarcoma Completed NCT02131480 Phase 2 Doxorubicin;Trabectedin
34 Activity of Trabectedin or Gemcitabine + Docetaxel in Uterine Leiomyosarcoma Completed NCT02249702 Phase 2 gemcitabine + docetaxel;trabectedin
35 Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1)(COMPLETED) Completed NCT00093080 Phase 2 ridaforolimus
36 Bevacizumab and Radiation Therapy for Sarcomas Completed NCT00356031 Phase 2 Bevacizumab
37 Alisertib in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01653028 Phase 2 Alisertib
38 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
39 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Completed NCT01614795 Phase 2 Temsirolimus
40 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
41 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
42 Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma Completed NCT00949325 Phase 1, Phase 2 temsirolimus (Torisel) plus liposomal doxorubicin (Doxil)
43 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
44 S0505 Sorafenib in Treating Patients With Advanced Soft Tissue Sarcomas Completed NCT00217620 Phase 2 sorafenib
45 Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00064220 Phase 2 soblidotin
46 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
47 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
48 Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00041249 Phase 2 brostallicin
49 Exatecan Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00041236 Phase 2 exatecan mesylate
50 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536

Search NIH Clinical Center for Liposarcoma

Cochrane evidence based reviews: liposarcoma

Genetic Tests for Liposarcoma

Anatomical Context for Liposarcoma

MalaCards organs/tissues related to Liposarcoma:

41
Adipocyte, T Cells, Bone, Skin, Liver, Colon, Kidney

Publications for Liposarcoma

Articles related to Liposarcoma:

(show top 50) (show all 1434)
# Title Authors Year
1
Dedifferentiated Liposarcoma Occurring in the Right Pulmonary Hilum. ( 29491279 )
2018
2
Tumor-targeting Salmonella typhimurium A1-R arrests a doxorubicin-resistant PDGFRA-amplified patient-derived orthotopic xenograft mouse model of pleomorphic liposarcoma. ( 29932244 )
2018
3
Dedifferentiated Liposarcoma With Rhabdomyosarcomatous Differentiation Producing HCG: A Case Report of a Diagnostic Pitfall. ( 29532681 )
2018
4
Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity. ( 29784880 )
2018
5
Amplification of FRS2 in atypical lipomatous tumour/well -differentiated liposarcoma and dedifferentiated liposarcoma: a clinicopathological and genetic study of 146 cases. ( 29368794 )
2018
6
Corrigendum to "Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor" (Hum Pathol 2016;54:92-99). ( 29958690 )
2018
7
Primary endobronchial liposarcoma successfully resected via bronchoscopy: A rare case report with genetic analysis. ( 29963153 )
2018
8
Dedifferentiated liposarcoma of the oral floor: A case study and literature review of 50 cases of head and neck neoplasm. ( 29740489 )
2018
9
A retrospective, single-center cohort study on 65 patients with primary retroperitoneal liposarcoma. ( 29434876 )
2018
10
A rare case of primary small bowel de-differentiated liposarcoma causing intussusception: A case report. ( 29901613 )
2018
11
Whole blood miRNA expression analysis reveals miR-3613-3p as a potential biomarker for dedifferentiated liposarcoma. ( 29689704 )
2018
12
Giant Primary Retroperitoneal Dedifferentiated Liposarcoma. ( 29959642 )
2018
13
Pleomorphic liposarcoma: An analysis of 6 case reports and literature review. ( 29465602 )
2018
14
Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp. ( 29349606 )
2018
15
Myxoid liposarcoma: local relapse and metastatic pattern in 43 patients. ( 29558901 )
2018
16
Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour. ( 29449935 )
2018
17
Extensive renal sinus lipomatosis in xanthogranulomatous pyelonephritis simulating liposarcoma. ( 29522292 )
2018
18
Simultaneous pulmonary and inferior vena cava tumor thromboembolism secondary to retroperitoneal pleomorphic liposarcoma. ( 29550849 )
2018
19
Mosaic-pattern dedifferentiation in liposarcoma and chondrosarcoma: imaging features of an uncommon form of dedifferentiation. ( 29362843 )
2018
20
FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway. ( 29190494 )
2018
21
Acute haemorrhage from a retroperitoneal liposarcoma: a rare presentation. ( 29437802 )
2018
22
The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center. ( 29723411 )
2018
23
Single metastasis of myxoid liposarcoma from the thigh to thyroid gland: a case report. ( 29587757 )
2018
24
Extended surgery using anterior mediastinal tracheostomy for recurrent mediastinal liposarcoma. ( 29415198 )
2018
25
Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma. ( 29848707 )
2018
26
Primary meningeal myxoid liposarcoma with aggressive behavior after recurrence: case report. ( 29915889 )
2018
27
Surgery for Abdominal Well-Differentiated Liposarcoma. ( 29335908 )
2018
28
Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status. ( 29309298 )
2018
29
Hibernation of masses suspected to be remnant tumors after surgical resection of retroperitoneal liposarcoma is related to improved overall survival. ( 29352382 )
2018
30
Complete Remission of Recurrent Retroperitoneal Liposarcoma after the Administration of Gemcitabine and Docetaxel as First-Line Adjuvant Chemotherapy: A Case Report. ( 29928214 )
2018
31
Successful resection of a giant thoracic myxoid liposarcoma. ( 29667901 )
2018
32
Devascularization of the superior mesenteric vein without reconstruction during surgery for retroperitoneal liposarcoma: A case report and review of literature. ( 29904248 )
2018
33
A dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features. ( 29446522 )
2018
34
Gastric liposarcoma in a patient with severe obesity. ( 29484946 )
2018
35
The potential of the CMB305 vaccine regimen to target NY-ESO-1 and improve outcomes for synovial sarcoma and myxoid/round cell liposarcoma patients. ( 29280411 )
2018
36
Dedifferentiated retroperitoneal liposarcoma spontaneously occurring in an aged SD rat. ( 29750003 )
2018
37
Cerebral Liposarcoma Embolus From Heart Metastasis Successfully Treated by Endovascular Extraction Followed by Cardiac Surgery. ( 29940813 )
2018
38
Metaplastic Breast Cancer Masquerading as Liposarcoma of the Breast: A Case Report following Oncoplastic Treatment. ( 29788010 )
2018
39
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma. ( 29372852 )
2018
40
Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution. ( 29977616 )
2018
41
Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma. ( 29651797 )
2018
42
Infiltration characteristics and influencing factors of retroperitoneal liposarcoma: Novel evidence for extended surgery and a tumor grading system. ( 29657244 )
2018
43
Dedifferentiated liposarcoma composed predominantly of rhabdoid/epithelioid cells: a frequently misdiagnosed highly aggressive variant. ( 29307627 )
2018
44
Lipoblastoma-like Tumor of the Vulva, an Important Benign Mimic of Myxoid Liposarcoma. ( 29300200 )
2018
45
Inflammatory calcified de-differentiated liposarcoma of the anterior mediastinum: an unusual case. ( 29885206 )
2018
46
Identification of inhibitors regulating cell proliferation and FUS-DDIT3 expression in myxoid liposarcoma using combined DNA, mRNA, and protein analyses. ( 29588491 )
2018
47
Salvage Surgery for Recurrent Retroperitoneal Well-Differentiated Liposarcoma: Early Reoperation may not Provide Benefit. ( 29520652 )
2018
48
High expression of fibroblast growth factor-21 in liposarcoma patients indicated better prognosis and less recurrence. ( 29953859 )
2018
49
Targeted next generation sequencing of well-differentiated/dedifferentiated liposarcoma reveals novel gene amplifications and mutations. ( 29731991 )
2018
50
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. ( 29610390 )
2018

Variations for Liposarcoma

Cosmic variations for Liposarcoma:

9
(show top 50) (show all 210)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6978413 ZFHX3 soft tissue,fat,liposarcoma,myxoid-round cell c.448C>A p.L150M 16:72959698-72959698 12
2 COSM3054546 XPO1 soft tissue,fat,liposarcoma,myxoid-round cell c.1288G>T p.V430L 2:61493011-61493011 12
3 COSM6987297 WT1 soft tissue,fat,liposarcoma,myxoid-round cell c.223G>A p.E75K 11:32434919-32434919 12
4 COSM6986268 TSC1 soft tissue,fat,liposarcoma,myxoid-round cell c.1079C>A p.T360N 9:132911064-132911064 12
5 COSM11333 TP53 soft tissue,fat,liposarcoma,myxoid-round cell c.499C>T p.Q167* 17:7675113-7675113 12
6 COSM10648 TP53 soft tissue,fat,liposarcoma,pleomorphic c.524G>A p.R175H 17:7675088-7675088 12
7 COSM10647 TP53 soft tissue,fat,liposarcoma,pleomorphic c.404G>T p.C135F 17:7675208-7675208 12
8 COSM10656 TP53 soft tissue,fat,liposarcoma,pleomorphic c.742C>T p.R248W 17:7674221-7674221 12
9 COSM45794 TP53 soft tissue,fat,liposarcoma,pleomorphic c.421T>G p.C141G 17:7675191-7675191 12
10 COSM44112 TP53 soft tissue,fat,liposarcoma,myxoid-round cell c.640C>T p.H214Y 17:7674891-7674891 12
11 COSM43632 TP53 soft tissue,fat,liposarcoma,pleomorphic c.493C>T p.Q165* 17:7675119-7675119 12
12 COSM10731 TP53 soft tissue,fat,liposarcoma,pleomorphic c.707A>G p.Y236C 17:7674256-7674256 12
13 COSM10672 TP53 soft tissue,fat,liposarcoma,pleomorphic c.577C>T p.H193Y 17:7674954-7674954 12
14 COSM6848516 TET2 soft tissue,fat,liposarcoma,myxoid-round cell c.3809C>T p.T1270I 4:105259624-105259624 12
15 COSM6921522 SDHA soft tissue,fat,liposarcoma,myxoid-round cell c.664T>G p.L222V 5:228227-228227 12
16 COSM1437480 RICTOR soft tissue,fat,liposarcoma,pleomorphic c.3404C>T p.T1135M 5:38950444-38950444 12
17 COSM1651764 RB1 soft tissue,fat,liposarcoma,pleomorphic c.1818T>A p.Y606* 13:48456207-48456207 12
18 COSM6966300 RB1 soft tissue,fat,liposarcoma,pleomorphic c.2632G>A p.D878N 13:48476812-48476812 12
19 COSM6906362 RAF1 soft tissue,fat,liposarcoma,pleomorphic c.1141G>A p.D381N 3:12591760-12591760 12
20 COSM5106 PTEN soft tissue,fat,liposarcoma,myxoid-round cell c.335T>C p.L112P 10:87933094-87933094 12
21 COSM5135 PTEN soft tissue,fat,liposarcoma,myxoid-round cell c.106G>A p.G36R 10:87894051-87894051 12
22 COSM5039 PTEN soft tissue,fat,liposarcoma,myxoid-round cell c.518G>A p.R173H 10:87952143-87952143 12
23 COSM1167954 PTEN soft tissue,fat,liposarcoma,myxoid-round cell c.485A>T p.D162V 10:87933244-87933244 12
24 COSM3416650 POLE soft tissue,fat,liposarcoma,myxoid-round cell c.2275C>T p.R759C 12:132667547-132667547 12
25 COSM6987724 PLK2 soft tissue,fat,liposarcoma,myxoid-round cell c.1337G>C p.R446P 5:58456073-58456073 12
26 COSM763 PIK3CA soft tissue,fat,liposarcoma,myxoid-round cell c.1633G>A p.E545K 3:179218303-179218303 12
27 COSM760 PIK3CA soft tissue,fat,liposarcoma,myxoid-round cell c.1624G>A p.E542K 3:179218294-179218294 12
28 COSM754 PIK3CA soft tissue,fat,liposarcoma,myxoid-round cell c.1035T>A p.N345K 3:179203765-179203765 12
29 COSM12597 PIK3CA soft tissue,fat,liposarcoma,myxoid-round cell c.3145G>C p.G1049R 3:179234302-179234302 12
30 COSM6903888 NOTCH2 soft tissue,fat,liposarcoma,myxoid-round cell c.5857C>T p.R1953C 1:119918478-119918478 12
31 COSM24452 NF1 soft tissue,fat,liposarcoma,pleomorphic c.1105C>T p.Q369* 17:31201079-31201079 12
32 COSM28019 NF1 soft tissue,fat,liposarcoma,pleomorphic c.4006C>T p.Q1336* 17:31249015-31249015 12
33 COSM6987300 NCOR1 soft tissue,fat,liposarcoma,myxoid-round cell c.4256C>T p.P1419L 17:16070422-16070422 12
34 COSM175679 MUTYH soft tissue,fat,liposarcoma,myxoid-round cell c.536G>A p.R179H 1:45332794-45332794 12
35 COSM6978412 MUTYH soft tissue,fat,liposarcoma,myxoid-round cell c.1022C>T p.P341L 1:45331816-45331816 12
36 COSM6987286 MLH1 soft tissue,fat,liposarcoma,myxoid-round cell c.2146G>A p.V716M 3:37050528-37050528 12
37 COSM517 KRAS soft tissue,fat,liposarcoma,myxoid-round cell c.34G>A p.G12S 12:25245351-25245351 12
38 COSM6906365 KMT2C soft tissue,fat,liposarcoma,pleomorphic c.12200C>A p.P4067H 7:152154086-152154086 12
39 COSM6906367 KMT2A soft tissue,fat,liposarcoma,pleomorphic c.8086C>T p.R2696* 11:118503987-118503987 12
40 COSM6924116 KMT2A soft tissue,fat,liposarcoma,myxoid-round cell c.5783G>T p.G1928V 11:118498063-118498063 12
41 COSM1651756 KIT soft tissue,fat,liposarcoma,myxoid-round cell c.2334G>C p.K778N 4:54731971-54731971 12
42 COSM216207 KDM6A soft tissue,fat,liposarcoma,pleomorphic c.3768C>G p.Y1256* 23:45090754-45090754 12
43 COSM1645298 JAK1 soft tissue,fat,liposarcoma,pleomorphic c.1595G>A p.R532H 1:64855562-64855562 12
44 COSM6987289 GATA2 soft tissue,fat,liposarcoma,myxoid-round cell c.436G>A p.G146S 3:128486162-128486162 12
45 COSM6664414 FLCN soft tissue,fat,liposarcoma,pleomorphic c.247G>A p.E83K 17:17227891-17227891 12
46 COSM6934579 FAT1 soft tissue,fat,liposarcoma,pleomorphic c.2806G>A p.V936I 4:186707022-186707022 12
47 COSM6934578 FAT1 soft tissue,fat,liposarcoma,pleomorphic c.2806G>A p.V936I 4:186707022-186707022 12
48 COSM6906369 ERBB2 soft tissue,fat,liposarcoma,pleomorphic c.2441G>A p.R814H 17:39724859-39724859 12
49 COSM1056635 EPHA5 soft tissue,fat,liposarcoma,pleomorphic c.1702G>A p.D568N 4:65404462-65404462 12
50 COSM6987287 EPCAM soft tissue,fat,liposarcoma,myxoid-round cell c.457A>G p.R153G 2:47375265-47375265 12

Copy number variations for Liposarcoma from CNVD:

7 (show all 36)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 13334 1 1 124300000 Gain Liposarcoma
2 16445 1 124300000 247249719 Loss Liposarcoma
3 20078 1 15300000 163800000 Amplification COAS1 Liposarcoma
4 20079 1 15300000 163800000 Amplification COAS2 Liposarcoma
5 20080 1 15300000 163800000 Amplification COAS3 Liposarcoma
6 20084 1 15300000 212100000 Gain Liposarcoma
7 42815 10 40300000 135374737 Loss Liposarcoma
8 55437 11 52900000 134452384 Loss Liposarcoma
9 61489 12 1 14800000 Loss Liposarcoma
10 67172 12 37282278 37312244 Amplified CHOP Liposarcoma
11 67787 12 44600000 69800000 Gain CDK4 liposarcomas
12 67788 12 44600000 69800000 Gain HMGA2 liposarcomas
13 67789 12 44600000 69800000 Gain MDM2 liposarcomas
14 69651 12 56140200 56152312 Amplified GLI1 Liposarcoma
15 69861 12 56374152 56401607 Amplified OS9 Liposarcoma
16 69873 12 56425050 56428293 Amplified TSPAN31 Liposarcoma
17 69880 12 56428269 56432431 Amplified CDK4 Liposarcoma
18 70737 12 64503703 64646338 Amplified HMGA2 Liposarcoma
19 71088 12 67488246 67520481 Amplified MDM2 Liposarcoma
20 77049 13 39500000 52200000 Loss Liposarcoma
21 77649 13 46200000 52200000 Deletion RB1 Liposarcoma
22 78496 13 52200000 114142980 Loss Liposarcoma
23 106733 17 1 11200000 Deletion Liposarcoma
24 108852 17 23200000 28800000 Deletion Liposarcoma
25 139560 2 183406981 183439743 Amplified OS1 Liposarcoma
26 149783 2 93300000 242951149 Gain Liposarcoma
27 149786 2 93300000 242951149 Loss Liposarcoma
28 166153 3 1 91700000 Gain Liposarcoma
29 166161 3 1 91700000 Loss Liposarcoma
30 179460 3 91700000 199501827 Gain Liposarcoma
31 187537 4 50700000 191273063 Loss Liposarcoma
32 191663 5 1 45800000 Gain Liposarcoma
33 200009 5 47700000 180857866 Gain Liposarcoma
34 210239 6 29900000 45200000 Gain Liposarcoma
35 217105 7 1 59100000 Gain Liposarcoma
36 225569 7 47600000 107200000 Gain Liposarcoma

Expression for Liposarcoma

Search GEO for disease gene expression data for Liposarcoma.

Pathways for Liposarcoma

Pathways related to Liposarcoma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 CDK4 CDKN2A MDM2 PPARG TP53
2 12.71 CDK4 CDKN2A MDM2 PPARG TP53
3 12.31 CDKN2A HMGA2 MDM2 TP53 VIM
4 12.29 CDK4 CDKN2A GPS2 TP53
5 12.27 CDK4 CDKN2A MDM2 TP53 VIM
6
Show member pathways
12.25 CDK4 CDKN2A MDM2 TP53
7 12.23 CDK4 CDKN2A MDM2 TP53
8 12.14 CDK4 CDKN2A MDM2 TP53
9 12.11 DDIT3 EWSR1 FUS YBX1
10 12 CDK4 CDKN2A MDM2 TP53
11 11.81 CDKN2A MDM2 TP53
12 11.72 CDK4 MDM2 TP53
13 11.71 CDK4 CDKN2A MDM2 TP53
14 11.6 CDKN2A MDM2 TP53
15
Show member pathways
11.59 CDKN2A MDM2 TP53
16 11.44 DDIT3 EWSR1 FUS HMGA2 MDM2 PPARG
17 11.42 CDKN2A MDM2 TP53
18 11.32 CDK4 MDM2 TP53
19 11.32 CDK4 CDKN2A MDM2 TP53
20 11.28 CDK4 MDM2 TP53
21 10.84 CDKN2A MDM2 TP53
22
Show member pathways
10.78 CDKN2A MDM2 TP53
23 10.76 CDK4 CDKN2A MDM2 TP53

GO Terms for Liposarcoma

Cellular components related to Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 CALB2 CDK4 CDKN2A DDIT3 DES EWSR1
2 senescence-associated heterochromatin focus GO:0035985 8.96 CDKN2A HMGA2
3 cytosol GO:0005829 10.07 CALB2 CDK4 CDKN2A DDIT3 DES GPS2
4 cytoplasm GO:0005737 10.03 CALB2 CD34 CDK4 CDKN2A DDIT3 DES
5 nucleoplasm GO:0005654 10.02 CDK4 CDKN2A DDIT3 FUS GPS2 HMGA2

Biological processes related to Liposarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 CDKN2A DDIT3 GPS2 HMGA2 PPARG TP53
2 positive regulation of apoptotic process GO:0043065 9.77 CDK4 CDKN2A HMGA2 PPARG TP53
3 negative regulation of transcription, DNA-templated GO:0045892 9.63 CDKN2A DDIT3 HMGA2 MDM2 PPARG TP53
4 negative regulation of neuron projection development GO:0010977 9.61 LRP1 MDM2 VIM
5 regulation of fat cell differentiation GO:0045598 9.56 GPS2 PPARG
6 positive regulation of cholesterol efflux GO:0010875 9.55 GPS2 LRP1
7 replicative senescence GO:0090399 9.54 CDKN2A TP53
8 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 9.52 DDIT3 TP53
9 ER overload response GO:0006983 9.51 DDIT3 TP53
10 negative regulation of transcription by RNA polymerase II GO:0000122 9.5 DDIT3 GPS2 HMGA2 MDM2 PPARG TP53
11 negative regulation of telomerase activity GO:0051974 9.49 PPARG TP53
12 amyloid fibril formation GO:1990000 9.48 CDKN2A MDM2
13 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.46 CDK4 CDKN2A
14 cellular response to actinomycin D GO:0072717 9.32 MDM2 TP53
15 senescence-associated heterochromatin focus assembly GO:0035986 9.26 CDKN2A HMGA2
16 positive regulation of gene expression GO:0010628 9.1 CD34 CDKN2A HMGA2 MDM2 TP53 VIM

Molecular functions related to Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.56 DDIT3 HMGA2 PPARG TP53
2 identical protein binding GO:0042802 9.56 DES EWSR1 FUS MDM2 PPARG TP53
3 disordered domain specific binding GO:0097718 9.33 CDKN2A MDM2 TP53
4 retinoid X receptor binding GO:0046965 9.32 FUS PPARG
5 transcription factor binding GO:0008134 9.1 CD34 CDKN2A DDIT3 HMGA2 PPARG TP53

Sources for Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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