Lissencephaly, X-Linked, 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lissencephaly, X-Linked, 1

MalaCards integrated aliases for Lissencephaly, X-Linked, 1:

Name: Lissencephaly, X-Linked, 1 ⁵⁷

Lissencephaly, X-Linked ⁵⁷ ²⁹ ¹³ ⁵⁵ ⁶

Xlis ⁵⁷ ⁵³ ⁷⁵

Lissencephaly and Agenesis of Corpus Callosum ⁵⁷ ⁵³

Subcortical Laminar Heterotopia, X-Linked ²⁹ ⁶

X-Linked Lissencephaly ⁵³ ⁷³

Double Cortex ⁷⁵ ⁷³

Lisx1 ⁵⁷ ⁷⁵

Lissencephaly Type 1 Due to Doublecortin Gene Mutation ⁵⁹

Subcortical Laminar Heterotopia, X-Linked, ⁵³

Subcortical Laminal Heterotopia, X-Linked ⁵⁷

Subcortical Band Heterotopia X-Linked ⁷⁵

Lissencephaly, X-Linked, Type 1 ) ⁴⁰

Subcortical Laminar Heterotopia ⁷⁵

X-Linked Lissencephaly Type 1 ⁵⁹

Subcortical Band Heterotopia ⁷³

Lissencephaly, X-Linked 1 ⁷⁵

Lissencephaly X-Linked ⁵³

Lisx ⁵³

Sclh ⁷⁵

Sbhx ⁷⁵

Characteristics:

Orphanet epidemiological data:

⁵⁹

lissencephaly type 1 due to doublecortin gene mutation
Inheritance: X-linked recessive; Age of onset: Adolescent,Childhood,Infancy,Neonatal;

OMIM:

⁵⁷

Miscellaneous:
onset in infancy
incomplete penetrance
highly variable phenotype in females
somatic or germline mosaicism may occur

Inheritance:
x-linked

HPO:

³²

lissencephaly, x-linked, 1:
Mortality/Aging death in infancy
Onset and clinical course incomplete penetrance infantile onset
Inheritance x-linked inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases
Anatomical: Neuronal diseases Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Congenital malformations, deformations and chromosomal abnormalities

Congenital malformations of the nervous system

Other congenital malformations of brain

Other reduction deformities of brain

Orphanet: ⁵⁹

Rare neurological diseases

Developmental anomalies during embryogenesis

External Ids:

OMIM ⁵⁷ 300067

Orphanet ⁵⁹ ORPHA2148

UMLS via Orphanet ⁷⁴ C1848199

ICD10 via Orphanet ³⁴ Q04.3

MedGen ⁴² C1848199 C1848070 C1848200

MeSH ⁴⁴ D054082 D054221

UMLS ⁷³ C1848199 C2931857

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Summaries for Lissencephaly, X-Linked, 1

UniProtKB/Swiss-Prot : ⁷⁵ Lissencephaly, X-linked 1: A classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'. Subcortical band heterotopia X-linked: SBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.

MalaCards based summary : Lissencephaly, X-Linked, 1, also known as lissencephaly, x-linked, is related to lissencephaly 1 and band heterotopia, and has symptoms including ataxia and seizures. An important gene associated with Lissencephaly, X-Linked, 1 is DCX (Doublecortin), and among its related pathways/superpathways are Cytoskeletal Signaling and Lissencephaly gene (LIS1) in neuronal migration and development. Affiliated tissues include cortex, brain and testes, and related phenotypes are seizures and muscular hypotonia

OMIM : ⁵⁷ Lissencephaly ('smooth brain') results from migrational arrest of cortical neurons short of their normal destination, and can result in profound mental retardation and seizures. In X-linked lissencephaly-1, affected males generally have more a severe phenotype compared to females. DCX mutations cause classic lissencephaly with mental retardation in hemizygous males and a milder phenotype known as subcortical band heterotopia in females, sometimes in the same family. The subcortical lamina heterotopia found in heterozygous females is also referred to as 'double cortex' (DC) syndrome (des Portes et al., 1997). There are several X-linked loci that affect neuronal migration, including the Aicardi locus (304050). (300067)

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Related Diseases for Lissencephaly, X-Linked, 1

Diseases in the Lissencephaly, X-Linked, 1 family:

Lissencephaly, X-Linked, 2

Diseases related to Lissencephaly, X-Linked, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)

#	Related Disease	Score	Top Affiliating Genes
1	lissencephaly 1	31.4	DCX PAFAH1B1
2	band heterotopia	29.0	DCX PAFAH1B1
3	lissencephaly	28.2	ARX DCX PAFAH1B1
4	lissencephaly, x-linked, 2	12.5
5	ichthyosis, x-linked	11.8
6	x-linked lissencephaly with abnormal genitalia	11.5
7	chromosome xq26.3 duplication syndrome	11.2
8	mccune-albright syndrome	9.8
9	fibrous dysplasia	9.8
10	pseudohypoparathyroidism	9.8
11	neuronitis	9.8
12	hypoglycemia	9.8
13	chromosome 17p13.3, centromeric, duplication syndrome	9.6	DCX PAFAH1B1
14	neuronal migration disorders	9.5	DCX PAFAH1B1
15	congenital nervous system abnormality	9.3	DCX PAFAH1B1
16	physical disorder	9.2	DCX PAFAH1B1
17	periventricular nodular heterotopia	9.0	DCX PAFAH1B1
18	lissencephaly with cerebellar hypoplasia	8.8	ARX DCX PAFAH1B1

Graphical network of the top 20 diseases related to Lissencephaly, X-Linked, 1:

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Symptoms & Phenotypes for Lissencephaly, X-Linked, 1

Symptoms via clinical synopsis from OMIM:

⁵⁷

Head And Neck Eyes:
nystagmus

Neurologic Central Nervous System:
seizures
ataxia
dysarthria
pachygyria
delayed motor development
more

Clinical features from OMIM:

300067

Human phenotypes related to Lissencephaly, X-Linked, 1:

⁵⁹ ³² (show all 15)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	seizures ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001250
2	muscular hypotonia ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0001252
3	hypertonia ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0001276
4	intellectual disability, severe ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0010864
5	feeding difficulties ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0011968
6	agenesis of corpus callosum ³²			HP:0001274
7	nystagmus ³²			HP:0000639
8	intellectual disability ³²			HP:0001249
9	ataxia ³²			HP:0001251
10	dysarthria ³²			HP:0001260
11	postnatal growth retardation ³²			HP:0008897
12	pachygyria ³²			HP:0001302
13	motor delay ³²			HP:0001270
14	micropenis ³²			HP:0000054
15	muscular hypotonia of the trunk ³²			HP:0008936

UMLS symptoms related to Lissencephaly, X-Linked, 1:

ataxia, seizures

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Drugs & Therapeutics for Lissencephaly, X-Linked, 1

Search Clinical Trials , NIH Clinical Center for Lissencephaly, X-Linked, 1

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Genetic Tests for Lissencephaly, X-Linked, 1

Genetic tests related to Lissencephaly, X-Linked, 1:

#	Genetic test	Affiliating Genes
1	Lissencephaly, X-Linked ²⁹	DCX
2	Subcortical Laminar Heterotopia, X-Linked ²⁹

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Anatomical Context for Lissencephaly, X-Linked, 1

MalaCards organs/tissues related to Lissencephaly, X-Linked, 1:

⁴¹

Cortex, Brain, Testes, Hypothalamus

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Publications for Lissencephaly, X-Linked, 1

Articles related to Lissencephaly, X-Linked, 1:

(show all 23)

#	Title	Authors	Year
1	A Neonate with X-linked Lissencephaly with Ambiguous Genitalia. ( 28553390 )	Minocha P....Sitaraman S.	2017
2	X-Linked Lissencephaly With Absent Corpus Callosum and Abnormal Genitalia: An Evolving Multisystem Syndrome With Severe Congenital Intestinal Diarrhea Disease. ( 29152528 )	Coman D....McGillivray G.	2017
3	A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies. ( 27292316 )	Tsai M.H....Tsai J.W.	2016
4	Watery diarrhea-hypopotassemia-acidosis syndrome like diarrhea in a case with X-linked lissencephaly with abnormal genitalia. ( 26129807 )	Tumgor G....Agin M.	2015
5	Analysis of the hypothalamus in a case of X-linked lissencephaly with abnormal genitalia (XLAG). ( 18842366 )	Miyata R....Kohyama J.	2009
6	Aristaless-related homeobox gene disruption leads to abnormal distribution of GABAergic interneurons in human neocortex: evidence based on a case of X-linked lissencephaly with abnormal genitalia (XLAG). ( 18458920 )	Okazaki S....Itoh M.	2008
7	Association between X-linked lissencephaly with ambiguous genitalia syndrome and lenticulostriate vasculopathy in neonate. ( 18412232 )	JagA8a M....Kwinta P.	2008
8	The location of DCX mutations predicts malformation severity in X-linked lissencephaly. ( 18685874 )	Leger P.L....Bahi-Buisson N.	2008
9	Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. ( 17460091 )	Colombo E....Broccoli V.	2007
10	[X-linked lissencephaly with absent corpus callosum and abnormal genitalia: a report of siblings followed from the prenatal period]. ( 17515135 )	Nanba Y....Ohno K.	2007
11	Central and gonadal hypogonadism in X-linked lissencephaly. ( 16995578 )	Halac I....Zimmerman D.	2006
12	X-linked lissencephaly with abnormal genitalia as a tangential migration disorder causing intractable epilepsy: proposal for a new term, &quot;interneuronopathy&quot;. ( 15921244 )	Kato M....Dobyns W.B.	2005
13	X-linked lissencephaly with abnormal genitalia associated with renal phosphate wasting. ( 15248105 )	Hahn A....Neubauer B.A.	2004
14	ARX mutations in X-linked lissencephaly with abnormal genitalia. ( 12874405 )	Uyanik G....Winkler J.	2003
15	X-linked lissencephaly in an Indian family. ( 14652450 )	Panda S....Sharma P.	2003
16	X-linked lissencephaly with absent corpus callosum and ambiguous genitalia (XLAG): clinical, magnetic resonance imaging, and neuropathological findings. ( 11891829 )	Bonneau D....GAclot A.	2002
17	Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. ( 12379852 )	Kitamura K....Morohashi K.	2002
18	X-linked lissencephaly with ambiguous genitalia: delineation of further case. ( 10982975 )	Ogata T....Hata J.I.	2000
19	Differences in the gyral pattern distinguish chromosome 17-linked and X-linked lissencephaly. ( 10430413 )	Dobyns W.B....Barkovich A.J.	1999
20	X-linked lissencephaly with absent corpus callosum and ambiguous genitalia. ( 10494089 )	Dobyns W.B....Viskochil D.	1999
21	A novel mutation of the doublecortin gene in Japanese patients with X-linked lissencephaly and subcortical band heterotopia. ( 10369164 )	Kato M....Hayasaka K.	1999
22	Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. ( 9489700 )	Gleeson J.G....Walsh C.A.	1998
23	Linkage and physical mapping of X-linked lissencephaly/SBH (XLIS): a gene causing neuronal migration defects in human brain. ( 9097958 )	Ross M.E....Walsh C.A.	1997

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Genes for Lissencephaly, X-Linked, 1

Genes related to Lissencephaly, X-Linked, 1 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	DCX	Doublecortin	Protein Coding	1690.69	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative germline mutation ⁵⁹ Causative variation ⁷⁵ Genetic Tests ²⁹ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Variants (show sections)	9489699 20301364 9489700 (more) 11468322 12552055 9097958 9489700 10369164 12223548 11331616 12590608 10036192 16564023 10515162 8757001 10213452 14741102 9837748 10826984 15607950 15632197 16530423 9747029 11597766 16100463
2	ARX	Aristaless Related Homeobox	Protein Coding	21.63	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	19605412 18412232 18808783 (more) 17515135 14631200 16724181 17641262 15921228 17571022
3	PAFAH1B1	Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1	Protein Coding	21.07	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	17571022 10826984
4	BLZF1	Basic Leucine Zipper Nuclear Factor 1	Protein Coding	6.4	Novoseek inferred ⁵⁵	12223548

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Variations for Lissencephaly, X-Linked, 1

UniProtKB/Swiss-Prot genetic disease variations for Lissencephaly, X-Linked, 1:

⁷⁵ (show all 42)

#	Symbol	AA change	Variation ID	SNP ID
1	DCX	p.Leu43Ser	VAR_007819	rs587783521
2	DCX	p.Ser47Arg	VAR_007820	rs104894783
3	DCX	p.Arg59Leu	VAR_007821	rs122457137
4	DCX	p.Arg59His	VAR_007822	rs122457137
5	DCX	p.Asp62Asn	VAR_007823	rs104894779
6	DCX	p.Arg78Leu	VAR_007824	rs104894784
7	DCX	p.Asp86His	VAR_007825
8	DCX	p.Gly100Ala	VAR_007826
9	DCX	p.Arg102Ser	VAR_007827
10	DCX	p.Tyr125His	VAR_007828	rs104894781
11	DCX	p.Tyr125Asp	VAR_007829
12	DCX	p.Arg178Leu	VAR_007830	rs587783559
13	DCX	p.Arg186Cys	VAR_007831	rs587783562
14	DCX	p.Pro191Arg	VAR_007832	rs587783566
15	DCX	p.Arg192Trp	VAR_007833	rs104894780
16	DCX	p.Asn200Lys	VAR_007834
17	DCX	p.Thr203Arg	VAR_007835	rs104894782
18	DCX	p.Ile214Thr	VAR_007836	rs587783574
19	DCX	p.Thr222Ile	VAR_007837
20	DCX	p.Gly223Glu	VAR_007838
21	DCX	p.Val236Ile	VAR_007839
22	DCX	p.Ile250Asn	VAR_007840
23	DCX	p.Ile250Thr	VAR_007841
24	DCX	p.Gly253Asp	VAR_007842
25	DCX	p.Arg89Gly	VAR_010536	rs104894785
26	DCX	p.Thr42Ile	VAR_026022
27	DCX	p.Lys50Asn	VAR_026023	rs587783523
28	DCX	p.Asn60Asp	VAR_026024
29	DCX	p.Gly67Glu	VAR_026025
30	DCX	p.Ala71Ser	VAR_026026	rs104894786
31	DCX	p.Leu97Arg	VAR_026027	rs587783537
32	DCX	p.Ile104Thr	VAR_026028
33	DCX	p.Arg178Cys	VAR_026029	rs587783558
34	DCX	p.Pro191Leu	VAR_026030
35	DCX	p.Arg196His	VAR_026031	rs56030372
36	DCX	p.Asn200Ile	VAR_026033
37	DCX	p.Thr203Ala	VAR_026034	rs587783570
38	DCX	p.Gly223Val	VAR_026035
39	DCX	p.Phe243Leu	VAR_026036
40	DCX	p.Ala251Ser	VAR_026037	rs587783585
41	DCX	p.Ala251Val	VAR_026038
42	DCX	p.Asp262Gly	VAR_077482	rs398124557

ClinVar genetic disease variations for Lissencephaly, X-Linked, 1:

⁶

(show all 38)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	DCX	DCX, 2-BP DEL, 691CT	deletion	Pathogenic
2	DCX	NM_178152.2(DCX): c.184G> A (p.Asp62Asn)	single nucleotide variant	Pathogenic	rs104894779	GRCh37	Chromosome X, 110653443: 110653443
3	DCX	NM_178152.2(DCX): c.184G> A (p.Asp62Asn)	single nucleotide variant	Pathogenic	rs104894779	GRCh38	Chromosome X, 111410215: 111410215
4	DCX	NM_178151.2(DCX): c.574C> T (p.Arg192Trp)	single nucleotide variant	Pathogenic	rs104894780	GRCh37	Chromosome X, 110644349: 110644349
5	DCX	NM_178151.2(DCX): c.574C> T (p.Arg192Trp)	single nucleotide variant	Pathogenic	rs104894780	GRCh38	Chromosome X, 111401121: 111401121
6	DCX	NM_178152.2(DCX): c.373T> C (p.Tyr125His)	single nucleotide variant	Pathogenic	rs104894781	GRCh37	Chromosome X, 110644550: 110644550
7	DCX	NM_178152.2(DCX): c.373T> C (p.Tyr125His)	single nucleotide variant	Pathogenic	rs104894781	GRCh38	Chromosome X, 111401322: 111401322
8	DCX	DCX, IVS4, G-A, +1	single nucleotide variant	Pathogenic
9	DCX	NM_178152.2(DCX): c.176G> T (p.Arg59Leu)	single nucleotide variant	Pathogenic	rs122457137	GRCh37	Chromosome X, 110653451: 110653451
10	DCX	NM_178152.2(DCX): c.176G> T (p.Arg59Leu)	single nucleotide variant	Pathogenic	rs122457137	GRCh38	Chromosome X, 111410223: 111410223
11	DCX	NM_178152.2(DCX): c.608C> G (p.Thr203Arg)	single nucleotide variant	Pathogenic	rs104894782	GRCh37	Chromosome X, 110644315: 110644315
12	DCX	NM_178152.2(DCX): c.608C> G (p.Thr203Arg)	single nucleotide variant	Pathogenic	rs104894782	GRCh38	Chromosome X, 111401087: 111401087
13	DCX	NM_178152.2(DCX): c.139A> C (p.Ser47Arg)	single nucleotide variant	Pathogenic	rs104894783	GRCh37	Chromosome X, 110653488: 110653488
14	DCX	NM_178152.2(DCX): c.139A> C (p.Ser47Arg)	single nucleotide variant	Pathogenic	rs104894783	GRCh38	Chromosome X, 111410260: 111410260
15	DCX	DCX, 2-BP INS, 36AG	insertion	Pathogenic
16	DCX	DCX, 2-BP DEL, 684CT	deletion	Pathogenic
17	DCX	NM_178152.2(DCX): c.233G> A (p.Arg78His)	single nucleotide variant	Pathogenic	rs104894784	GRCh37	Chromosome X, 110653394: 110653394
18	DCX	NM_178152.2(DCX): c.233G> A (p.Arg78His)	single nucleotide variant	Pathogenic	rs104894784	GRCh38	Chromosome X, 111410166: 111410166
19	DCX	NM_178152.2(DCX): c.265C> G (p.Arg89Gly)	single nucleotide variant	Pathogenic	rs104894785	GRCh37	Chromosome X, 110653362: 110653362
20	DCX	NM_178152.2(DCX): c.265C> G (p.Arg89Gly)	single nucleotide variant	Pathogenic	rs104894785	GRCh38	Chromosome X, 111410134: 111410134
21	DCX	NM_178151.2(DCX): c.587G> A (p.Arg196His)	single nucleotide variant	Pathogenic	rs56030372	GRCh37	Chromosome X, 110644336: 110644336
22	DCX	NM_178151.2(DCX): c.587G> A (p.Arg196His)	single nucleotide variant	Pathogenic	rs56030372	GRCh38	Chromosome X, 111401108: 111401108
23	DCX	NM_178152.2(DCX): c.211G> T (p.Ala71Ser)	single nucleotide variant	Pathogenic	rs104894786	GRCh37	Chromosome X, 110653416: 110653416
24	DCX	NM_178152.2(DCX): c.211G> T (p.Ala71Ser)	single nucleotide variant	Pathogenic	rs104894786	GRCh38	Chromosome X, 111410188: 111410188
25	DCX	NM_178151.2(DCX): c.781C> T (p.Gln261Ter)	single nucleotide variant	Pathogenic	rs587783588	GRCh37	Chromosome X, 110576306: 110576306
26	DCX	NM_178151.2(DCX): c.781C> T (p.Gln261Ter)	single nucleotide variant	Pathogenic	rs587783588	GRCh38	Chromosome X, 111333078: 111333078
27	DCX	NM_178151.2(DCX): c.705+1del	deletion	Pathogenic		GRCh37	Chromosome X, 110644217: 110644217
28	DCX	NM_178151.2(DCX): c.705+1del	deletion	Pathogenic		GRCh38	Chromosome X, 111400989: 111400989
29	DCX	NM_178152.2(DCX): c.684_685delCT (p.Tyr229Hisfs)	deletion	Pathogenic		GRCh38	Chromosome X, 111401010: 111401011
30	DCX	NM_178152.2(DCX): c.684_685delCT (p.Tyr229Hisfs)	deletion	Pathogenic		GRCh37	Chromosome X, 110644238: 110644239
31	DCX	NM_178151.2(DCX): c.544G> T (p.Val182Phe)	single nucleotide variant	Pathogenic		GRCh37	Chromosome X, 110644379: 110644379
32	DCX	NM_178151.2(DCX): c.544G> T (p.Val182Phe)	single nucleotide variant	Pathogenic		GRCh38	Chromosome X, 111401151: 111401151
33	DCX	NM_178152.2(DCX): c.355_356delCT (p.Leu119Glyfs)	deletion	Pathogenic		GRCh38	Chromosome X, 111410043: 111410044
34	DCX	NM_178152.2(DCX): c.355_356delCT (p.Leu119Glyfs)	deletion	Pathogenic		GRCh37	Chromosome X, 110653271: 110653272
35	DCX	NM_000555.3(DCX): c.433T> A (p.Tyr145Asn)	single nucleotide variant	Likely pathogenic		GRCh37	Chromosome X, 110653437: 110653437
36	DCX	NM_000555.3(DCX): c.433T> A (p.Tyr145Asn)	single nucleotide variant	Likely pathogenic		GRCh38	Chromosome X, 111410209: 111410209
37	DCX	NM_000555.3(DCX): c.191C> T (p.Pro64Leu)	single nucleotide variant	Likely pathogenic	rs761786389	GRCh38	Chromosome X, 111410784: 111410784
38	DCX	NM_000555.3(DCX): c.191C> T (p.Pro64Leu)	single nucleotide variant	Likely pathogenic	rs761786389	GRCh37	Chromosome X, 110654012: 110654012

Copy number variations for Lissencephaly, X-Linked, 1 from CNVD:

⁷

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	257508	X	103600000	116800000	Copy number	DCX	X-linked lissencephaly
2	261298	X	17100000	19200000	Copy number	ARX	X-linked lissencephaly
3	261366	X	18331857	18460326	Deletion	CDKL5	X-linked lissencephaly
4	261706	X	24900000	37500000	Copy number	ARX	X-linked lissencephaly
5	266516	X	98200000	110500000	Copy number	DCX	X-linked lissencephaly

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Expression for Lissencephaly, X-Linked, 1

Search GEO for disease gene expression data for Lissencephaly, X-Linked, 1.

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Pathways for Lissencephaly, X-Linked, 1

Pathways related to Lissencephaly, X-Linked, 1 according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	11.44	DCX PAFAH1B1
2	Lissencephaly gene (LIS1) in neuronal migration and development ¹	10.11	DCX PAFAH1B1

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GO Terms for Lissencephaly, X-Linked, 1

Cellular components related to Lissencephaly, X-Linked, 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	microtubule associated complex	GO:0005875	8.62	DCX PAFAH1B1

Biological processes related to Lissencephaly, X-Linked, 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organism development	GO:0007275	9.54	ARX DCX PAFAH1B1
2	cell differentiation	GO:0030154	9.5	ARX DCX PAFAH1B1
3	nervous system development	GO:0007399	9.43	ARX DCX PAFAH1B1
4	brain development	GO:0007420	9.4	DCX PAFAH1B1
5	hippocampus development	GO:0021766	9.16	DCX PAFAH1B1
6	layer formation in cerebral cortex	GO:0021819	8.96	DCX PAFAH1B1
7	neuron migration	GO:0001764	8.8	ARX DCX PAFAH1B1

Molecular functions related to Lissencephaly, X-Linked, 1 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	microtubule binding	GO:0008017	8.62	DCX PAFAH1B1

Sources

Sources for Lissencephaly, X-Linked, 1

¹ BioSystems

² BitterDB

³ CDC

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