Lissencephaly, X-Linked, 2 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

LISX2 MCID: LSS037 MIFTS: 36	Lissencephaly, X-Linked, 2 (LISX2) Categories: Endocrine diseases, Fetal diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Lissencephaly, X-Linked, 2

MalaCards integrated aliases for Lissencephaly, X-Linked, 2:

Name: Lissencephaly, X-Linked, 2 ⁵⁶ ⁷¹

Hydranencephaly with Abnormal Genitalia ⁵⁶ ²⁹ ¹³ ⁶

Lissencephaly, X-Linked 2 ⁵⁶ ⁷³

Lissencephaly 2, X-Linked ²⁹ ⁶

Lisx2 ⁵⁶ ⁷³

Xlisg ⁵⁶ ⁷³

Xlag ⁵⁶ ⁷³

X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome ⁵⁸

Lissencephaly, X-Linked, with Ambiguous Genitalia; Xlag ⁵⁶

Lissencephaly, X-Linked, with Ambiguous Genitalia ⁵⁶

X-Linked Lissencephaly with Ambiguous Genitalia ⁵⁸

Lissencephaly X-Linked with Ambiguous Genitalia ⁷³

X-Linked Lissencephaly with Abnormal Genitalia ⁵⁸

Chromosome Xq26.3 Duplication Syndrome ⁷¹

Lissencephaly, X-Linked, Type 2 ³⁹

Xlag Syndrome ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

x-linked lissencephaly with abnormal genitalia
Inheritance: X-linked recessive; Age of onset: Neonatal; Age of death: early childhood;

OMIM:

⁵⁶

Inheritance:
x-linked

Miscellaneous:
early death in males
some female carriers are more mildly affected

HPO:

³¹

lissencephaly, x-linked, 2:
Inheritance x-linked inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Fetal diseases Rare diseases
Anatomical: Neuronal diseases Endocrine diseases Reproductive diseases Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Congenital malformations, deformations and chromosomal abnormalities

Congenital malformations of the nervous system

Other congenital malformations of brain

Other reduction deformities of brain

Orphanet: ⁵⁸

Rare neurological diseases

Rare endocrine diseases

Developmental anomalies during embryogenesis

External Ids:

OMIM ⁵⁶ 300215

OMIM Phenotypic Series ⁵⁶ PS607432

MeSH ⁴³ D054082

ICD10 via Orphanet ³³ Q04.3

UMLS via Orphanet ⁷² C1846171

Orphanet ⁵⁸ ORPHA452

MedGen ⁴¹ C1846171 C1846172

UMLS ⁷¹ C1846171 C3891556

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Summaries for Lissencephaly, X-Linked, 2

OMIM : ⁵⁶ X-linked lissencephaly-2 (LISX2) is a developmental disorder characterized by structural brain anomalies, early-onset intractable seizures, severe psychomotor retardation, and ambiguous genitalia. Males are severely affected and often die within the first days or months of life, whereas females may be unaffected or have a milder phenotype (Bonneau et al., 2002). LISX2 is part of a phenotypic spectrum of disorders caused by mutation in the ARX gene comprising a nearly continuous series of developmental disorders ranging from hydranencephaly and lissencephaly to Proud syndrome (300004) to infantile spasms without brain malformations (EIEE1; 308350) to syndromic (309510) and nonsyndromic (300419) mental retardation (Kato et al., 2004; Wallerstein et al., 2008). For a general phenotypic description and a discussion of genetic heterogeneity of lissencephaly, see LIS1 (607432). (300215)

MalaCards based summary : Lissencephaly, X-Linked, 2, also known as hydranencephaly with abnormal genitalia, is related to x-linked lissencephaly with abnormal genitalia and lissencephaly, and has symptoms including snoring and thick skin. An important gene associated with Lissencephaly, X-Linked, 2 is ARX (Aristaless Related Homeobox). Affiliated tissues include brain, testes and cortex, and related phenotypes are agenesis of corpus callosum and seizures

UniProtKB/Swiss-Prot : ⁷³ Lissencephaly, X-linked 2: A classic type lissencephaly associated with abnormal genitalia. Patients have severe congenital or postnatal microcephaly, lissencephaly, agenesis of the corpus callosum, neonatal-onset intractable epilepsy, poor temperature regulation, chronic diarrhea, and ambiguous or underdeveloped genitalia.

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Related Diseases for Lissencephaly, X-Linked, 2

Diseases in the Lissencephaly, X-Linked, 1 family:

Lissencephaly, X-Linked, 2

Diseases related to Lissencephaly, X-Linked, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)

#	Related Disease	Score
1	x-linked lissencephaly with abnormal genitalia	11.7
2	lissencephaly	11.6
3	chromosome xq26.3 duplication syndrome	11.5
4	corpus callosum, agenesis of, with abnormal genitalia	11.2
5	mental retardation, x-linked, with or without seizures, arx-related	11.2
6	epileptic encephalopathy, early infantile, 1	11.2
7	partington x-linked mental retardation syndrome	11.2
8	cryptorchidism, unilateral or bilateral	10.3
9	lissencephaly, x-linked, 1	10.3
10	corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia	10.3
11	microcephaly	10.2
12	pachygyria	10.2
13	hypotonia	10.2
14	west syndrome	10.2
15	exocrine pancreatic insufficiency	10.2
16	dcx-related disorders	10.2
17	myoclonus	10.2
18	neuronal migration disorders	10.2
19	cerebral malformation	10.2
20	vesicoureteral reflux 1	10.1
21	miller-dieker lissencephaly syndrome	10.1
22	gonadal agenesis	10.1
23	patent ductus arteriosus 1	10.1
24	alacrima, achalasia, and mental retardation syndrome	10.1
25	diarrhea	10.1
26	hypogonadism	10.1
27	hypogonadotropism	10.1
28	febrile seizures	10.1

Graphical network of the top 20 diseases related to Lissencephaly, X-Linked, 2:

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Symptoms & Phenotypes for Lissencephaly, X-Linked, 2

Human phenotypes related to Lissencephaly, X-Linked, 2:

⁵⁸ ³¹ (show all 41)

#	Description	Orphanet Frequency	HPO Source Accession
1	agenesis of corpus callosum ⁵⁸ ³¹	Very frequent (99-80%)	HP:0001274
2	seizures ⁵⁸ ³¹	Very frequent (99-80%)	HP:0001250
3	muscular hypotonia ⁵⁸ ³¹	Frequent (79-30%)	HP:0001252
4	spasticity ⁵⁸ ³¹	Occasional (29-5%)	HP:0001257
5	micrognathia ⁵⁸ ³¹	Occasional (29-5%)	HP:0000347
6	ventriculomegaly ⁵⁸ ³¹	Frequent (79-30%)	HP:0002119
7	ambiguous genitalia ⁵⁸ ³¹	Very frequent (99-80%)	HP:0000062
8	pachygyria ⁵⁸ ³¹	Very frequent (99-80%)	HP:0001302
9	low-set ears ³¹		HP:0000369
10	high palate ³¹		HP:0000218
11	intellectual disability ⁵⁸	Very frequent (99-80%)
12	hyperreflexia ³¹		HP:0001347
13	global developmental delay ⁵⁸	Very frequent (99-80%)
14	wide nasal bridge ³¹		HP:0000431
15	malabsorption ⁵⁸	Frequent (79-30%)
16	cryptorchidism ⁵⁸	Very frequent (99-80%)
17	ventricular septal defect ⁵⁸	Occasional (29-5%)
18	microcephaly ⁵⁸	Very frequent (99-80%)
19	feeding difficulties in infancy ³¹		HP:0008872
20	prominent forehead ⁵⁸	Occasional (29-5%)
21	long philtrum ³¹		HP:0000343
22	generalized hypotonia ³¹		HP:0001290
23	death in infancy ⁵⁸	Frequent (79-30%)
24	patent ductus arteriosus ⁵⁸	Occasional (29-5%)
25	severe global developmental delay ³¹		HP:0011344
26	hypohidrosis ⁵⁸	Frequent (79-30%)
27	specific learning disability ³¹		HP:0001328
28	exocrine pancreatic insufficiency ⁵⁸	Occasional (29-5%)
29	prominent nasal bridge ³¹		HP:0000426
30	aganglionic megacolon ⁵⁸	Occasional (29-5%)
31	decreased testicular size ³¹		HP:0008734
32	thin upper lip vermilion ³¹		HP:0000219
33	micropenis ³¹		HP:0000054
34	high forehead ³¹		HP:0000348
35	diarrhea ³¹		HP:0002014
36	hypoplasia of penis ⁵⁸	Very frequent (99-80%)
37	wide anterior fontanel ³¹		HP:0000260
38	profound global developmental delay ³¹		HP:0012736
39	gliosis ³¹		HP:0002171
40	long upper lip ³¹		HP:0011341
41	duane anomaly ³¹		HP:0009921

Symptoms via clinical synopsis from OMIM:

⁵⁶

Head And Neck Ears:
low-set ears

Head And Neck Nose:
wide nasal bridge
prominent nasal root
pinched nasal alae

Head And Neck Head:
high forehead
large anterior fontanelle

Head And Neck Mouth:
long upper lip
thin upper lip
high-arched palate

Endocrine Features:
hypothalamic dysfunction
impaired temperature regulation

Neurologic Central Nervous System:
hyperreflexia
hypotonia
enlarged ventricles
agenesis of the corpus callosum
psychomotor retardation, profound
more

Head And Neck Face:
micrognathia
long philtrum

Genitourinary External Genitalia Male:
ambiguous genitalia
small penis
small testes
underdeveloped scrotal folds

Abdomen Gastrointestinal:
poor feeding
diarrhea, chronic

Head And Neck Eyes:
thin optic nerves
duane anomaly (reported in 1 female)

Clinical features from OMIM:

300215

UMLS symptoms related to Lissencephaly, X-Linked, 2:

snoring, thick skin

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Drugs & Therapeutics for Lissencephaly, X-Linked, 2

Search Clinical Trials , NIH Clinical Center for Lissencephaly, X-Linked, 2

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Genetic Tests for Lissencephaly, X-Linked, 2

Genetic tests related to Lissencephaly, X-Linked, 2:

#	Genetic test	Affiliating Genes
1	Lissencephaly 2, X-Linked ²⁹	ARX
2	Hydranencephaly with Abnormal Genitalia ²⁹

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Anatomical Context for Lissencephaly, X-Linked, 2

MalaCards organs/tissues related to Lissencephaly, X-Linked, 2:

⁴⁰

Brain, Testes, Cortex, Skin

Sources

Publications for Lissencephaly, X-Linked, 2

Articles related to Lissencephaly, X-Linked, 2:

#	Title	Authors	PMID	Year
1	Mutations of ARX are associated with striking pleiotropy and consistent genotype-phenotype correlation. ⁵⁶ ⁶ ⁶¹	Kato M...Dobyns WB	14722918	2004
2	Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. ⁶ ⁵⁶	Kitamura K...Morohashi K	12379852	2002
3	X-linked lissencephaly with absent corpus callosum and ambiguous genitalia (XLAG): clinical, magnetic resonance imaging, and neuropathological findings. ⁶ ⁵⁶	Bonneau D...Gelot A	11891829	2002
4	Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations. ⁶	Cho G...Golden JA	22252899	2012
5	Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. ⁵⁶	Marsh E...Golden JA	19439424	2009
6	Expansion of the ARX spectrum. ⁵⁶	Wallerstein R...Friez M	18462864	2008
7	ARX mutations in X-linked lissencephaly with abnormal genitalia. ⁶	Uyanik G...Winkler J	12874405	2003
8	X-linked lissencephaly with ambiguous genitalia: delineation of further case. ⁵⁶	Ogata T...Hata JI	10982975	2000
9	X-linked lissencephaly with absent corpus callosum and ambiguous genitalia. ⁵⁶	Dobyns WB...Viskochil D	10494089	1999
10	New X-linked syndrome with seizures, acquired micrencephaly, and agenesis of the corpus callosum. ⁵⁶	Proud VK...Carpenter NJ	1605226	1992

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Genes for Lissencephaly, X-Linked, 2

Genes related to Lissencephaly, X-Linked, 2 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ARX	Aristaless Related Homeobox	Protein Coding	1667.96	Molecular basis known ⁵⁶ Pathogenic ⁶ Causative germline mutation (loss of function) ⁵⁸ Causative variation ⁷³ Genetic Tests ²⁹ GeneCards inferred via : Disorders Variants (show sections)	11891829 12379852 14722918 (more) 12874405 22252899

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Variations for Lissencephaly, X-Linked, 2

ClinVar genetic disease variations for Lissencephaly, X-Linked, 2:

⁶ (show all 34) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	ARX	NM_139058.3(ARX):c.1117C>T (p.Gln373Ter)	SNV	Pathogenic	11193	rs104894740	X:25028379-25028379	X:25010262-25010262
2	ARX	NM_139058.3(ARX):c.306_308GGC[17] (p.Ala109_Ala115dup)	short repeat	Pathogenic	11186	rs387906492	X:25031779-25031781	X:25013662-25013664
3	ARX	ARX, 32-BP DEL, NT420	deletion	Pathogenic	11190
4	ARX	NM_139058.3(ARX):c.995G>A (p.Arg332His)	SNV	Pathogenic	11192	rs111033612	X:25031117-25031117	X:25013000-25013000
5	ARX	NM_139058.3(ARX):c.1187dup (p.Gly397fs)	duplication	Pathogenic	11194	rs1328291159	X:25025489-25025489	X:25007372-25007372
6	ARX	ARX, EX1-2DEL	deletion	Pathogenic	11195
7	ARX	NM_139058.3(ARX):c.1028T>A (p.Leu343Gln)	SNV	Pathogenic	11197	rs104894741	X:25031084-25031084	X:25012967-25012967
8	ARX	NM_139058.3(ARX):c.1105G>T (p.Glu369Ter)	SNV	Pathogenic	11201	rs104894746	X:25028391-25028391	X:25010274-25010274
9	ARX	NM_139058.3(ARX):c.232G>T (p.Glu78Ter)	SNV	Pathogenic	11205	rs267606666	X:25031880-25031880	X:25013763-25013763
10	ARX	NM_139058.3(ARX):c.441_464dup (p.Ala148_Ala155dup)	duplication	Pathogenic	96455	rs398124510	X:25031648-25031671	X:25013531-25013554
11	ARX	NM_139058.3(ARX):c.1372del (p.Ala458fs)	deletion	Pathogenic	157744	rs587783187	X:25025304-25025304	X:25007187-25007187
12	ARX	NM_139058.3(ARX):c.1414C>T (p.Arg472Ter)	SNV	Pathogenic	157746	rs587783189	X:25025262-25025262	X:25007145-25007145
13	ARX	NM_139058.3(ARX):c.1465del (p.Ala489fs)	deletion	Pathogenic	157748	rs587783191	X:25023011-25023011	X:25004894-25004894
14	ARX	NM_139058.3(ARX):c.335_368del (p.Ala112fs)	deletion	Pathogenic	157756	rs587783199	X:25031744-25031777	X:25013627-25013660
15	ARX	NM_139058.3(ARX):c.617del (p.Gly206fs)	deletion	Pathogenic	157759	rs587783202	X:25031495-25031495	X:25013378-25013378
16	ARX	NM_139058.3(ARX):c.995G>T (p.Arg332Leu)	SNV	Pathogenic	157765	rs111033612	X:25031117-25031117	X:25013000-25013000
17	ARX	NM_139058.3(ARX):c.1471dup (p.Leu491fs)	duplication	Pathogenic	210321	rs797045292	X:25023005-25023005	X:25004888-25004888
18	ARX	NM_139058.3(ARX):c.1449-82_1469dup	duplication	Pathogenic	210320	rs1556046904	X:25023007-25023109	X:25004890-25004992
19	ARX	NM_139058.3(ARX):c.1337dup (p.Pro447fs)	duplication	Pathogenic	210319	rs797045291	X:25025339-25025339	X:25007222-25007222
20	ARX	NM_139058.3(ARX):c.1164_1165insCAAAG (p.Ala389fs)	insertion	Pathogenic	210318	rs797045290	X:25025511-25025512	X:25007394-25007395
21	ARX	NM_139058.3(ARX):c.1096del (p.Asp366fs)	deletion	Pathogenic	210316	rs797045289	X:25028400-25028400	X:25010283-25010283
22	ARX	NM_139058.3(ARX):c.562_563delinsTA (p.Ala188Ter)	indel	Pathogenic	210335	rs797045303	X:25031549-25031550	X:25013432-25013433
23	ARX	NM_139058.3(ARX):c.409dup (p.Glu137fs)	duplication	Pathogenic	210330	rs797045298	X:25031703-25031703	X:25013586-25013586
24	ARX	NM_139058.3(ARX):c.306_308GGC[18] (p.Ala108_Ala115dup)	short repeat	Pathogenic	210327	rs387906492	X:25031777-25031800	X:25013660-25013683
25	ARX	NM_139058.2(ARX):c.304_305ins21 (p.?)	insertion	Pathogenic	210326		X:25031807-25031808	X:25013690-25013691
26	ARX	NM_139058.2(ARX):c.1120-82_1469dup	duplication	Pathogenic	210317
27	ARX	NM_139058.3(ARX):c.790del (p.Arg264fs)	deletion	Pathogenic	287023	rs886043552	X:25031322-25031322	X:25013205-25013205
28	ARX	NM_139058.3(ARX):c.1535_1549delinsGGCGCAG (p.Val512fs)	indel	Pathogenic	434399	rs1556046720	X:25022927-25022941	X:25004810-25004824
29	ARX	NM_139058.3(ARX):c.1141del (p.Ala381fs)	deletion	Pathogenic	434396	rs1556049694	X:25025535-25025535	X:25007418-25007418
30	ARX	NM_139058.3(ARX):c.426_461dup (p.Gly143_Ala154dup)	duplication	Likely pathogenic	210331	rs1556056131	X:25031651-25031686	X:25013534-25013569
31	ARX	NM_139058.3(ARX):c.1121T>A (p.Val374Asp)	SNV	Likely pathogenic	157740	rs587783183	X:25025555-25025555	X:25007438-25007438
32	ARX	NM_139058.3(ARX):c.1134C>A (p.Asn378Lys)	SNV	Likely pathogenic	157741	rs587783184	X:25025542-25025542	X:25007425-25007425
33	ARX	NM_139058.3(ARX):c.1170C>T (p.Gly390=)	SNV	Conflicting interpretations of pathogenicity	234531	rs761632870	X:25025506-25025506	X:25007389-25007389
34	ARX	NM_139058.3(ARX):c.187G>A (p.Ala63Thr)	SNV	Uncertain significance	581240		X:25033668-25033668	X:25015551-25015551

UniProtKB/Swiss-Prot genetic disease variations for Lissencephaly, X-Linked, 2:

⁷³

#	Symbol	AA change	Variation ID	SNP ID
1	ARX	p.Arg332His	VAR_015178	rs111033612
2	ARX	p.Leu343Gln	VAR_015179	rs104894741
3	ARX	p.Arg332Pro	VAR_033260
4	ARX	p.Pro353Arg	VAR_033262
5	ARX	p.Ala521Thr	VAR_033263	rs746120093

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Expression for Lissencephaly, X-Linked, 2

Search GEO for disease gene expression data for Lissencephaly, X-Linked, 2.

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Pathways for Lissencephaly, X-Linked, 2

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GO Terms for Lissencephaly, X-Linked, 2

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Sources for Lissencephaly, X-Linked, 2

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Lissencephaly, X-Linked, 2 (LISX2)

Aliases & Classifications for Lissencephaly, X-Linked, 2

MalaCards integrated aliases for Lissencephaly, X-Linked, 2:

Characteristics:

Orphanet epidemiological data:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Lissencephaly, X-Linked, 2

Related Diseases for Lissencephaly, X-Linked, 2

Diseases in the Lissencephaly, X-Linked, 1 family:

Diseases related to Lissencephaly, X-Linked, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Lissencephaly, X-Linked, 2:

Symptoms & Phenotypes for Lissencephaly, X-Linked, 2

Human phenotypes related to Lissencephaly, X-Linked, 2:

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

UMLS symptoms related to Lissencephaly, X-Linked, 2:

Drugs & Therapeutics for Lissencephaly, X-Linked, 2

Genetic Tests for Lissencephaly, X-Linked, 2

Genetic tests related to Lissencephaly, X-Linked, 2:

Anatomical Context for Lissencephaly, X-Linked, 2

MalaCards organs/tissues related to Lissencephaly, X-Linked, 2:

Publications for Lissencephaly, X-Linked, 2

Articles related to Lissencephaly, X-Linked, 2:

Genes for Lissencephaly, X-Linked, 2

Genes related to Lissencephaly, X-Linked, 2 (1 elite genes):

Variations for Lissencephaly, X-Linked, 2

ClinVar genetic disease variations for Lissencephaly, X-Linked, 2:

UniProtKB/Swiss-Prot genetic disease variations for Lissencephaly, X-Linked, 2:

Expression for Lissencephaly, X-Linked, 2

Pathways for Lissencephaly, X-Linked, 2

GO Terms for Lissencephaly, X-Linked, 2

Sources for Lissencephaly, X-Linked, 2