Listeriosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Listeriosis

MalaCards integrated aliases for Listeriosis:

Name: Listeriosis ¹¹ ¹⁹ ⁵⁸ ⁷⁵ ⁵³ ² ⁴³ ¹⁴ ¹⁶ ⁷¹ ³¹ ³³

Listeria Infection ¹¹ ¹⁹ ⁵⁸ ⁷⁵ ² ³³

Infection by Listeria Monocytogenes ¹¹ ³³

Infection Due to Listeria Monocytogenes ³³

Listeria Monocytogenes Infection ¹⁹

Listerial Foodborne Infection ³³

Listeria Infections ⁴¹

Circling Disease ³³

Listerellosis ³³

Characteristics:

Prevelance:

1-9/1000000 (Europe, Worldwide, United States, Austria, Czech Republic, Denmark, Estonia, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Slovakia, Slovenia, Spain, Sweden, United Kingdom, Iceland, Norway) 1-9/100000 (Belgium, Finland) <1/1000000 (Bulgaria, Croatia, Cyprus, Romania) ⁵⁸

Age Of Onset:

All ages ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Gastrointestinal diseases Immune diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³²

Certain infectious and parasitic diseases

Other bacterial diseases

Listeriosis

Cutaneous listeriosis

Listerial meningitis and meningoencephalitis

Listerial sepsis

Listeriosis, unspecified

Other forms of listeriosis

ICD11: ³³

Certain infectious or parasitic diseases

Other bacterial diseases

Listeriosis

Listeriosis, unspecified

Other specified listeriosis

Orphanet: ⁵⁸

Rare infectious diseases

External Ids:

Disease Ontology ¹¹ DOID:11573

ICD9CM ³⁴ 027.0

MeSH ⁴³ D008088

NCIt ⁴⁹ C82994

SNOMED-CT ⁶⁸ 186315001

ICD10 ³¹ A32 A32.9

MESH via Orphanet ⁴⁴ D008088

ICD10 via Orphanet ³² A32.0 A32.1 A32.7 more

UMLS via Orphanet ⁷² C0023860

Orphanet ⁵⁸ ORPHA533

EFO ¹⁶ EFO_0007347

ICD11 ³³ 419706488 419706488/other 419706488/unspecified

UMLS ⁷¹ C0023860

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Summaries for Listeriosis

GARD: ¹⁹ A Listeria infection or listeriosis is an infection caused by a bacteria known as Listeria monocytogenes. It mainly affects newborn infants, elderly patients, pregnant women and patients who have low immunity. Listeria can be spread by several methods. A common cause is ingestion (food-borne transmission) of unpasteurized milk or contaminated vegetables. It can also be transmitted from mother to fetus during pregnancy or directly to the newborn at the time of delivery. Listeriosis can cause a variety of symptoms, depending on the person and the part of the body affected. Pregnant women typically have only fever and other flu-like symptoms, such as fatigue and muscle aches. However, infections during pregnancy can lead to miscarriage, stillbirth, premature delivery, or severe infection of the newborn, including generalized infection (sepsis) or inflammation of the membranes that cover the brain (meningitis). Sometimes listeriosis involves many organs and presents with masses filled with pus (microabscesses or granulomas). Older children with Listeria infections frequently develop meningitis.

MalaCards based summary: Listeriosis, also known as listeria infection, is related to toxoplasmosis and meningoencephalitis, and has symptoms including vomiting, fever and back pain. An important gene associated with Listeriosis is ACTA1 (Actin Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drug Amoxicillin has been mentioned in the context of this disorder. Affiliated tissues include brain, liver and t cells, and related phenotypes are fever and vomiting

MedlinePlus: ⁴¹ Listeriosis is a foodborne illness caused by Listeria monocytogenes, bacteria found in soil and water. It can be in a variety of raw foods as well as in processed foods and foods made from unpasteurized milk. Listeria is unlike many other germs because it can grow even in the cold temperature of the refrigerator. Symptoms include fever and chills, headache, upset stomach and vomiting. Treatment is with antibiotics. Anyone can get the illness. But it is most likely to affect pregnant women and unborn babies, older adults, and people with weak immune systems. To reduce your risk: Use precooked and ready-to-eat foods as soon as you can Avoid raw milk and raw milk products Heat ready-to-eat foods and leftovers until they are steaming hot Wash fresh fruits and vegetables Avoid rare meat and refrigerated smoked seafood Centers for Disease Control and Prevention

Orphanet: ⁵⁸ A rare bacterial infectious disease caused by the foodborne pathogen Listeria monocytogenes, characterized by a febrile gastroenteritis, which is usually mild and self-limiting in otherwise healthy persons, but can progress to severe illness in at-risk groups like pregnant women, elderly people, immunocompromised people, and neonates. Complications include sepsis, meningitis, and encephalitis. Listeriosis during pregnancy usually occurs during the third trimester and may lead to preterm labor, miscarriage, stillbirth, or intrauterine infection of the unborn child.

Disease Ontology: ¹¹ A primary bacterial infectious disease that results in infection, has material basis in Listeria monocytogenes, which is transmitted by ingestion of contaminated food or raw milk or transmitted by congenital method. Ingestion of Listeria by pregnant women has symptom nausea, has symptom vomiting, has symptom diarrhea, has symptom fever, has symptom malaise, has symptom back pain, and has symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

CDC: ² Listeriosis is a serious infection usually caused by eating food contaminated with the bacterium Listeria monocytogenes. An estimated 1,600 people get listeriosis each year, and about 260 die. The infection is most likely to sicken pregnant women and their newborns, adults aged 65 or older, and people with weakened immune systems.

Wikipedia: ⁷⁵ Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although L.... more...

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Related Diseases for Listeriosis

Diseases related to Listeriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 851)

#	Related Disease	Score	Top Affiliating Genes
1	toxoplasmosis	31.3	TNF IL10 IDO1
2	meningoencephalitis	31.2	TNF IL10 CD8A CD4 CCR6
3	meningitis	30.8	TNF TLR2 MBL2 IL10
4	alcohol use disorder	30.7	TNF H2AC18 CD4 CCR6
5	encephalitis	30.7	TNF TLR2 IL10 IFNB1 IDO1
6	kawasaki disease	30.7	TNF TLR2 MBL2
7	bacterial meningitis	30.6	TNF TLR2 IL10
8	peritonitis	30.6	TNF TLR2 ITGAM IL10
9	stomatitis	30.5	TNF IL10 IFNB1 CD4
10	listeria meningitis	30.5	TNF NDUFA9 IFNB1 CD8A
11	bronchiolitis obliterans	30.5	TNF TLR2 IL10
12	bronchiolitis	30.5	TNF TLR2 IL10
13	acquired immunodeficiency syndrome	30.5	TNF ITGAM IL10 CD4
14	mast cell neoplasm	30.5	PRF1 ICOSLG H2AC18 CD8A
15	alveolar echinococcosis	30.5	IL10 CD8A CD4
16	q fever	30.5	TNF TLR2 MBL2 IL10
17	lymphadenitis	30.4	TNF IL10 ICOSLG CCR6
18	granulomatous hepatitis	30.4	TNF CD8A CD4
19	cerebritis	30.4	TNF CD8A CD4
20	bell's palsy	30.4	TNF CD8A CD4
21	candidiasis	30.4	TNF TLR2 MBL2 IL10
22	vaginitis	30.4	TNF TLR2 IL10 CD4 CCR6
23	psoriatic arthritis	30.4	TNF TLR2 IL10 ICOSLG CCR6
24	echinococcosis	30.4	TNF TLR2 IL10 CD8A
25	toxic shock syndrome	30.4	TNF TLR2 IL10
26	exanthem	30.4	TNF IL10 ICOSLG H2AC18 CD8A CD4
27	spondyloarthropathy 1	30.4	TNF IL10 ICOSLG CD8A CD4 CCR6
28	leishmaniasis	30.4	TNF TLR2 ITGAM IL10
29	endocarditis	30.4	TNF TLR2 IL10
30	orchitis	30.4	TNF IL10 H2AC18 CD8A CD4 CCR6
31	henoch-schoenlein purpura	30.3	TNF ICOSLG CD4 CCR6
32	shigellosis	30.3	IL10 H2AC18 CCR6
33	secondary syphilis	30.3	TNF CD8A CD4
34	salmonellosis	30.3	TNF TLR2 ITGAX ITGAM IL10 CD8A
35	congenital toxoplasmosis	30.3	TNF IL10 CD8A CD4
36	syphilis	30.3	TNF TLR2 CD8A CD4 CCR6
37	crohn's disease	30.3	TNF TLR2 IL10 ICOSLG H2AC18 CD8A
38	leptospirosis	30.3	TNF TLR2 IL10
39	common cold	30.3	TNF IL10 IFNB1 ICOSLG CD8A CD4
40	legionnaire disease	30.3	TNF TLR2 CD4
41	lyme disease	30.2	TNF TLR2 IFNB1
42	plague	30.2	TNF TLR2 IL10 H2AC18 CD8A CD4
43	tularemia	30.2	TNF TLR2 MBL2 CD8A CD4 CCR6
44	proliferative glomerulonephritis	30.2	ICOSLG H2AC18 CCR6
45	respiratory failure	30.2	TNF IL10 IFNB1 H2AC18 CD8A CD4
46	human cytomegalovirus infection	30.2	TNF IL10 IFNB1 CD8A CD4 CCR6
47	pneumocystosis	30.2	TNF IL10 CD8A CD4 CCR6
48	t cell deficiency	30.2	IL10 ICOSLG CD8A CD4 CCR6
49	granulomatous dermatitis	30.2	TNF CD8A CD4
50	temporal arteritis	30.2	TNF IL10 CD8A CD4 CCR6

Comorbidity relations with Listeriosis via Phenotypic Disease Network (PDN):

Acute Cystitis	Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Listeriosis:

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Symptoms & Phenotypes for Listeriosis

Human phenotypes related to Listeriosis:

⁵⁸ ³⁰ (show top 50) (show all 70)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	fever ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001945
2	vomiting ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002013
3	fatigue ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012378
4	myalgia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003326
5	meningitis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001287
6	headache ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002315
7	nausea ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002018
8	chills ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025143
9	stiff neck ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025258
10	hypoglycorrhachia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0011972
11	increased csf protein ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002922
12	bacteremia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031864
13	seizure ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001250
14	ataxia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001251
15	tremor ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001337
16	cranial nerve paralysis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0006824
17	immunodeficiency ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002721
18	myoclonus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001336
19	irritability ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000737
20	back pain ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003418
21	abdominal pain ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002027
22	arthralgia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002829
23	premature birth ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001622
24	respiratory failure ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002878
25	hemiparesis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001269
26	diarrhea ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002014
27	loss of consciousness ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0007185
28	pyelonephritis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0012330
29	brain abscess ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0030049
30	nuchal rigidity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0031179
31	abnormality of the anterior fontanelle ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000236
32	somatic sensory dysfunction ³⁰	Occasional (7.5%)		HP:0003474
33	intellectual disability ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001249
34	hearing impairment ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000365
35	congestive heart failure ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001635
36	jaundice ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000952
37	stroke ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001297
38	pericarditis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001701
39	myocarditis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0012819
40	endocarditis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0100584
41	conjunctivitis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000509
42	osteomyelitis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002754
43	sepsis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0100806
44	liver abscess ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0100523
45	cholecystitis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001082
46	respiratory distress ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002098
47	pneumonia ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002090
48	pustule ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0200039
49	peritonitis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002586
50	visual loss ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000572

Symptoms:

¹¹

• vomiting
• fever
• back pain
• headache

• diarrhea
• nausea
• malaise

UMLS symptoms related to Listeriosis:

fever; pruritus

MGI Mouse Phenotypes related to Listeriosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.83	CCR6 CD4 CD8A ICOSLG IDO1 IFNAR1
2	hematopoietic system	MP:0005397	9.5	CCR6 CD4 CD8A ICOSLG IDO1 IFNAR1

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Drugs & Therapeutics for Listeriosis

Drugs for Listeriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Amoxicillin

Approved, Vet_approved

26787-78-0

33613

Synonyms:

(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

6-(a-Amino-4-hydroxyphenylacetamido)penicillanic acid

6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin

6-(p-Hydroxy-a-aminophenylacetamido)penicillanate

6-(p-Hydroxy-a-aminophenylacetamido)penicillanic acid

6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanate

6-(p-Hydroxy-alpha-aminophenylacetamido)penicillanic acid

6-(p-Hydroxy-α-aminophenylacetamido)penicillanate

6-(p-Hydroxy-α-aminophenylacetamido)penicillanic acid

6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 9ci

a-Amino-p-hydroxybenzylpenicillin

Actimoxi

Almodan

alpha-Amino-p-hydroxybenzylpenicillin

AMC

Amix

AMIX 125

AMIX 250

AMIX 500

Amoclen

Amolin

Amopen

Amopenixin

Amoram

AMOX

Amox 250 cap 250MG

Amox 500 cap 500MG

Amox S 125 sus 125mg/5ML

Amox S 250 sus 250mg/5ML

Amoxi

Amoxibiotic

Amoxicaps

Amoxicilina

Amoxicilina [INN-Spanish]

Amoxicillin

Amoxicillin (anhydrous)

Amoxicillin and clavulanate potassium

Amoxicillin anhydrous

Amoxicillin clariana brand

AMOXICILLIN HYDRATE

Amoxicillin monopotassium salt

Amoxicillin monosodium salt

Amoxicillin pediatric

Amoxicillin sodium

Amoxicillin trihydrate

Amoxicillin(usan)

Amoxicillin, (r*)-isomer

Amoxicilline

Amoxicilline [INN-French]

Amoxicillinum

Amoxicillinum [INN-Latin]

Amoxid

Amoxiden

AMOXIDENT 250

AMOXIDENT 500

AMOXI-INJECT

Amoxil

AMOXIL FIZTAB

AMOXIL SF

Amoxi-mast

AMOXI-TABS

Amoxivet

Amoxycilin

Amoxycillin

AMOXYCILLIN ANHYDROUS

Amoxycillin trihydrate

Amoxycillin, ban

Amoxymed

AMPC

Amrit

Anemolin

Anhydrous, amoxicillin

Apo-amoxi

Apo-amoxi cap 250MG

Apo-amoxi cap 500MG

Apo-amoxi PWR for susp 125mg/5ML

Apo-amoxi PWR for susp 250mg/5ML

Apo-amoxi sugar free

AQUACIL

Aspenil

AUGMENTIN '125'

AUGMENTIN '200'

AUGMENTIN '250'

AUGMENTIN '400'

AUGMENTIN '500'

AUGMENTIN '875'

AUGMENTIN es-600

AX

Biomox

Bristamox

BRL 2333

BRL-2333

Cemoxin

Clamoxyl

Clamoxyl (SKB)

Clamoxyl g.a.

Clamoxyl parenteral

Clariana brand OF amoxicillin

D-(-)-alpha-Amino-p-hydroxybenzyl penicillin

D-(-)-alpha-Amino-p-hydroxybenzylpenicillin

D-(alpha-Amino-p-hydroxybenzyl)penicillin

D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid

D-Amoxicillin

DEDOXIL

Delacillin

Dispermox

Efpenix

Flemoxin

FLEMOXIN SOLUTAB

G.A., clamoxyl

Galenamox

Gen-amoxicillin 250MG

Gen-amoxicillin 500MG

Hiconcil

Histocillin

Hydroxyampicillin

Ibiamox

Imacillin

Lamoxy

Larotid

Metafarma capsules

Metifarma capsules

Moxacin

Moxal

Moxatag

Novamoxin cap 250MG

Novamoxin cap 500MG

Novamoxin sus 125mg/5ML

Novamoxin sus 250mg/5ML

NSC-277174

Nu-amoxi cap 250MG

Nu-amoxi cap 500MG

Nu-amoxi sus 125/5ML

Nu-amoxi sus 250mg/5ML

Ospamox

Pamoxicillin

Parenteral, clamoxyl

Penamox

Pfizer brand OF amoxicillin sodium salt

PHL-Amoxicillin

p-Hydroxyampicillin

Piramox

PMS-Amoxicillin

Polymox

Prevpac

Pro amox PWR for oral susp 125mg/5ML

Pro amox-250 cap 250MG

Pro amox-500 cap 500MG

Pro-amox-250 orl sus 250mg/5ML

RESPILLIN

R-Hydroxyampicillin

Rimoxallin

Robamox

Sauracillin

Sawamox PM

SmithKline beecham brand OF amoxicillin sodium salt

Sodium, amoxicillin

Sumox

Tolodina

Trihydrate, amoxicillin

Trimox

Unicillin

Utimox

Vetramox

VETREMOX

Wymox

Zimox

ZOXYCIL 250

ZOXYCIL 500

Α-amino-p-hydroxybenzylpenicillin

Interventional clinical trials:

#	Name	Status	NCT ID
1	Multicentric Observational National Analysis of Listeriosis and Listeria : Evaluation of the Neurological Consequences of Perinatal Listeriosis Infection	Completed	NCT02580812
2	Genetic Susceptibility and Biomarkers in Listeriosis (MONALISA-GENBIO)	Completed	NCT02924220
3	Genetic Susceptibility to Listeriosis - Listeria-GEN	Recruiting	NCT03357536
4	Multicentric Observational NAtional Study on LISteriosis and ListeriA	Recruiting	NCT01520597

Search NIH Clinical Center for Listeriosis

Cochrane evidence based reviews: listeriosis

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Genetic Tests for Listeriosis

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Anatomical Context for Listeriosis

Organs/tissues related to Listeriosis:

MalaCards : Brain, Liver, T Cells, Kidney, Bone Marrow, Heart, Skin

Sources

Publications for Listeriosis

Articles related to Listeriosis:

(show top 50) (show all 5342)

#	Title	Authors	PMID	Year
1	Newly Designed Primers for the Sequencing of the inlA Gene of Lineage I and II Listeria monocytogenes Isolates. ⁶² ⁴¹	Magagna G...Filipello V	36430584	2022
2	Assessment of the molecular epidemiology and genetic multiplicity of Listeria monocytogenes recovered from ready-to-eat foods following the South African listeriosis outbreak. ⁶² ⁴¹	Kayode AJ...Okoh AI	36418424	2022
3	Listeriosis outbreak caused by contaminated stuffed pork, Andalusia, Spain, July to October 2019. ⁶² ⁴¹	Fernandez-Martinez NF...Lorusso N	36305337	2022
4	Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. ⁵³ ⁶²	Popov A...Schultze JL	17111046	2006
5	Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection. ⁵³ ⁶²	Mackler AM...Pollard JW	12517946	2003
6	Listeriolysin and IrpA are major protein targets of the human humoral response against Listeria monocytogenes. ⁵³ ⁶²	Grenningloh R...Weiss S	9284184	1997
7	Imaging of Uncommon Bacterial, Rickettsia, Spirochete, and Fungal Infections. ⁶²	Saini J...Lee A	36404049	2023
8	Growth of food-borne pathogens Listeria and Salmonella and spore-forming Paenibacillus and Bacillus in commercial plant-based milk alternatives. ⁶²	Bartula K...Callanan M	36309444	2023
9	Maternal and obstetric outcomes of listeria pregnancy: insights from a national cohort. ⁶²	Craig A...Dotters-Katz S	35686719	2022
10	Neglected listeria infection in pregnancy in China: 93 cases. ⁶²	Xu L...Wu Y	35264053	2022
11	Invasive listeriosis outbreaks and salmon products: a genomic, epidemiological study. ⁶²	Lachmann R...Wilking H	35380514	2022
12	Horizontal Gene Transfer and Loss of Serotype-Specific Genes in Listeria monocytogenes Can Lead to Incorrect Serotype Designations with a Commonly-Employed Molecular Serotyping Scheme. ⁶²	Brown P...Kathariou S	36472431	2022
13	Fatal Listeria monocytogenes septicemia and meningitis complicated by Candida glabrata fungemia: a case report. ⁶²	Grima P...Romano A	36053118	2022
14	Response of sensitive and resistant Listeria monocytogenes strains against bacteriocins produced by different Enterococcus spp. strains. ⁶²	Ibarguren C...Audisio MC	36181756	2022
15	A systematic review and meta-analysis of the prevalence of Listeria monocytogenes in South-East Asia; a one-health approach of human-animal-food-environment. ⁶²	Jibo GG...Jamaluddin TZMT	36277096	2022
16	The magnitude of cell invasion and cell-to-cell spread of Listeria monocytogenes is correlated with serotype-specific traits. ⁶²	Camargo AC...Nero LA	36108483	2022
17	Antibiotic Resistance Profile of Listeria monocytogenes Recovered from Ready-to-Eat Foods Surveyed in South Africa. ⁶²	Kayode AJ...Okoh AI	36075088	2022
18	Quantitative risk assessment model to investigate the public health impact of varying Listeria monocytogenes allowable levels in different food commodities: A retrospective analysis. ⁶²	Sampedro F...Hedberg CW	36182750	2022
19	Genetic diversity, antibiotic resistance, and virulence profiles of Listeria monocytogenes from retail meat and meat processing. ⁶²	Li X...Wang J	36461311	2022
20	Serotype-identifying ions in Listeria monocytogenes using matrix-associated laser desorption ionization-time of flight mass spectrometry. ⁶²	Abdelhamed H...Lawrence ML	36466572	2022
21	Inhibition of Listeria monocytogenes in Fresh Cheese Using a Bacteriocin-Producing Lactococcus lactis CAU2013 Strain. ⁶²	Yoon SH...Kim GB	36415575	2022
22	Characterisation of Listeria monocytogenes Isolates from Hunted Game and Game Meat from Finland. ⁶²	Fredriksson-Ahomaa M...Paulsen P	36429271	2022
23	Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection. ⁶²	Zhang YS...Chinn YE	35614130	2022
24	Asymptomatic Carriage of Listeria monocytogenes by Animals and Humans and Its Impact on the Food Chain. ⁶²	Schoder D...Martlbauer E	36360084	2022
25	Complications Associated with Foodborne Listeriosis: A Scoping Review. ⁶²	Pogreba-Brown K...Hoffman S	36367547	2022
26	A subtractive proteomics and immunoinformatics approach towards designing a potential multi-epitope vaccine against pathogenic Listeriamonocytogenes. ⁶²	Rahman S...Das AK	36150556	2022
27	Listeria monocytogenes bacteremia mimicking the systemic metastasis of adrenal cancer: a case report. ⁶²	Hatakeyama Y...Konno S	36243700	2022
28	Maternal sepsis caused by Listeria monocytogenes with a fatal fetal outcome. ⁶²	Dunphy L...Fowler G	36192031	2022
29	Brain abscess caused by Listeria monocytogenes: a case report and literature review. ⁶²	Zhang C...Yi Z	35695050	2022
30	Comparative Genomics of Listeria monocytogenes Isolates from Ruminant Listeriosis Cases in the Midwest United States. ⁶²	Cardenas-Alvarez MX...Bergholz TM	36314928	2022
31	New Insights into Listeria monocytogenes Antimicrobial Resistance, Virulence Attributes and Their Prospective Correlation. ⁶²	Elsayed ME...Abousaty AI	36290105	2022
32	Potential antimicrobial activities of probiotics and their derivatives against Listeria monocytogenes in food field: A review. ⁶²	Wu M...Li Z	36076464	2022
33	Rhombencephalitis in Pregnancy-A Challenging Case of Probable Listeria Infection. ⁶²	Ho AEP...Sykes L	36295036	2022
34	Genomic Surveillance of Listeria monocytogenes in Taiwan, 2014 to 2019. ⁶²	Tsai YH...Chiou CS	36222695	2022
35	A quantitative risk assessment of Listeria monocytogenes from prevalence and concentration data: Application to a traditional ready to eat (RTE) meat product. ⁶²	Hadjicharalambous C...Cenci-Goga B	35952465	2022
36	Sugar Modification of Wall Teichoic Acids Determines Serotype-Dependent Strong Biofilm Production in Listeria monocytogenes. ⁶²	Park M...Jeon B	36190419	2022
37	Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes. ⁶²	Mayer RL...Impens F	36241641	2022
38	Efficacy of cleaning and sanitation methods against Listeria innocua on apple packing equipment surfaces. ⁶²	Ruiz-Llacsahuanga B...Critzer F	35953171	2022
39	Listeria monocytogenes post-outbreak management - When could a food production be considered under control again? ⁶²	Stessl B...Wagner M	35985077	2022
40	Cultivation Conditions of Spinach and Rocket Influence Epiphytic Growth of Listeria monocytogenes. ⁶²	Culliney P...Schmalenberger A	36230132	2022
41	Occurrence and Molecular Characterization of Multidrug-Resistant Vegetable-Borne Listeria monocytogenes Isolates. ⁶²	Ntshanka Z...Okoh AI	36290011	2022
42	Listeria monocytogenes Infection Alters the Content and Function of Extracellular Vesicles Produced by Trophoblast Stem Cells. ⁶²	Kaletka J...Hardy JW	36154271	2022
43	CD8+ T cell memory is sustained in mice by hepatic stellate cells. ⁶²	Chen YT...Kung JT	36106384	2022
44	The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity. ⁶²	Chen X...Dong C	36106640	2022
45	Inhibitory Effect against Listeria monocytogenes of Carbon Nanoparticles Loaded with Copper as Precursors of Food Active Packaging. ⁶²	Scattareggia Marchese A...Lanni L	36230015	2022
46	Lifestyle of Listeria monocytogenes and food safety: Emerging listericidal technologies in the food industry. ⁶²	Vidovic S...Fletcher GC	36062812	2022
47	Fetal Loss and Preterm Birth Caused by Intraamniotic Haemophilus influenzae Infection, New Zealand. ⁶²	Hills T...Thomas M	35997306	2022
48	Genome-Wide Association Study of Listeria monocytogenes Isolates Causing Three Different Clinical Outcomes. ⁶²	Cardenas-Alvarez MX...Bergholz TM	36296210	2022
49	Prevalence and Population Diversity of Listeria monocytogenes Isolated from Dairy Cattle Farms in the Cantabria Region of Spain. ⁶²	Varsaki A...Martinez-Suarez JV	36139336	2022
50	Listeria monocytogenes in foods-From culture identification to whole-genome characteristics. ⁶²	Osek J...Wieczorek K	36171778	2022

Sources

Genes for Listeriosis

Genes related to Listeriosis (0 elite genes):

(show all 34)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	14.32	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9284184
2	TNF	Tumor Necrosis Factor	Protein Coding	14.25	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	IDO1	Indoleamine 2,3-Dioxygenase 1	Protein Coding	13.96	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Proteins (show sections)	12517946 17111046
4	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.03	DISEASES inferred ¹⁴ ¹⁴
5	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	8.16	DISEASES inferred ¹⁴ ¹⁴
6	PYDC1	Pyrin Domain Containing 1	Protein Coding	7.46	DISEASES inferred ¹⁴
7	NDUFA9	NADH:Ubiquinone Oxidoreductase Subunit A9	Protein Coding	7.35	DISEASES inferred ¹⁴
8	CD8A	CD8a Molecule	Protein Coding	7.32	DISEASES inferred ¹⁴
9	MBL2	Mannose Binding Lectin 2	Protein Coding	7.29	GeneCards inferred via : Publications (show sections)
10	CD4	CD4 Molecule	Protein Coding	6.95	DISEASES inferred ¹⁴
11	H2AC18	H2A Clustered Histone 18	Protein Coding	6.73	DISEASES inferred ¹⁴ ¹⁴
12	KLRG1	Killer Cell Lectin Like Receptor G1	Protein Coding	6.61	DISEASES inferred ¹⁴
13	ITGAX	Integrin Subunit Alpha X	Protein Coding	6.48	DISEASES inferred ¹⁴
14	IL10	Interleukin 10	Protein Coding	6.44	DISEASES inferred ¹⁴
15	IFNB1	Interferon Beta 1	Protein Coding	6.38	DISEASES inferred ¹⁴
16	MIR125A	MicroRNA 125a	RNA Gene	6.37	DISEASES inferred ¹⁴ ¹⁴
17	PRF1	Perforin 1	Protein Coding	6.37	DISEASES inferred ¹⁴
18	ITGAM	Integrin Subunit Alpha M	Protein Coding	6.32	DISEASES inferred ¹⁴
19	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	6.28	DISEASES inferred ¹⁴
20	TLR2	Toll Like Receptor 2	Protein Coding	6.25	DISEASES inferred ¹⁴
21	IL6	Interleukin 6	Protein Coding	6.23	DISEASES inferred ¹⁴
22	IL1B	Interleukin 1 Beta	Protein Coding	6.21	DISEASES inferred ¹⁴
23	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	6.2	DISEASES inferred ¹⁴
24	LGI2	Leucine Rich Repeat LGI Family Member 2	Protein Coding	6.19	DISEASES inferred ¹⁴
25	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	6.18	DISEASES inferred ¹⁴
26	IL7R	Interleukin 7 Receptor	Protein Coding	6.16	DISEASES inferred ¹⁴
27	CDH1	Cadherin 1	Protein Coding	6.14	DISEASES inferred ¹⁴
28	SELL	Selectin L	Protein Coding	6.13	DISEASES inferred ¹⁴
29	TBX21	T-Box Transcription Factor 21	Protein Coding	6.1	DISEASES inferred ¹⁴
30	IRF3	Interferon Regulatory Factor 3	Protein Coding	6.09	DISEASES inferred ¹⁴
31	IL2	Interleukin 2	Protein Coding	6.07	DISEASES inferred ¹⁴
32	IL18	Interleukin 18	Protein Coding	6.05	DISEASES inferred ¹⁴
33	BAHD1	Bromo Adjacent Homology Domain Containing 1	Protein Coding	6.05	DISEASES inferred ¹⁴
34	IL4	Interleukin 4	Protein Coding	6.03	DISEASES inferred ¹⁴

Sources

Variations for Listeriosis

Sources

Expression for Listeriosis

Search GEO for disease gene expression data for Listeriosis.

Sources

Pathways for Listeriosis

Pathways directly related to Listeriosis:

#	Pathway	Source
1	InlB-mediated entry of Listeria monocytogenes into host cell	Reactome ⁶⁶
2	Listeria monocytogenes entry into host cells	Reactome ⁶⁶
3	InlA-mediated entry of Listeria monocytogenes into host cells	Reactome ⁶⁶

Pathways related to Listeriosis according to GeneCards Suite gene sharing:

(show all 26)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.77	TNF TLR2 MBL2 KLRG1 ITGAX ITGAM
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.26	TNF TLR2 ITGAX ITGAM IL10 CD4
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.21	CD4 IFNAR1 IFNB1 IL10 ITGAM ITGAX
4	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.74	TNF TLR2 MBL2 IFNB1 IFNAR1
5	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways Arrhythmogenic right ventricular cardiomyopathy ⁷⁴ BMP Pathway ⁶⁴ Calpain Protease Regulates Cellular Mechanics ⁶⁴ Caspase Cascade ⁶⁴ nNOS Signaling in Skeletal Muscle ⁶⁴ Presynaptic depolarization and calcium channel opening ⁶⁶ TOB in Osteoblast Signaling ⁶⁴	12.67	TNF PRF1 ITGAX ITGAM ACTA1
6	NF-kappaB Signaling ³	12.45	TNF TLR2 IL10 IDO1 CD8A
7	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.92	TNF IL10 IFNB1 IFNAR1 CD8A CD4
8	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.81	TNF ITGAX ITGAM IL10
9	Host-pathogen interaction of human coronaviruses - interferon induction ⁷⁴ Show member pathways Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶⁰ SARS coronavirus and innate immunity ⁷⁴ Type I interferon induction and signaling during SARS-CoV-2 infection ⁷⁴	11.78	TLR2 IFNB1 IFNAR1
10	Allograft rejection ⁷⁴	11.77	TNF PRF1 IL10
11	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.76	TNF TLR2 IL10 CD4
12	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.7	TNF ITGAX ITGAM IL10 CD8A CD4
13	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.67	IFNB1 CD8A CD4
14	Burn wound healing ⁷⁴	11.66	TNF IFNB1 ACTA1
15	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.59	TNF ITGAX IL10 ICOSLG
16	TYROBP causal network in microglia ⁷⁴	11.55	ITGAX ITGAM CD4
17	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.52	TNF TLR2 IL10
18	Agrin Interactions at Neuromuscular Junction ⁶⁴	11.5	ITGAX ITGAM ACTA1
19	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.44	TNF IL10 IFNB1
20	THC Differentiation Pathway ⁶⁴	11.4	CD4 IFNAR1 IL10 TNF
21	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.36	TNF ITGAM IFNB1
22	MSP-RON Signaling ⁶⁴	11.35	ACTA1 ITGAM TLR2 TNF
23	Innate Lymphoid Cells Differentiation ⁶⁵	11.34	TNF ITGAM IL10 CD8A CD4 CCR6
24	Kynurenine pathway and links to cell senescence ⁷⁴ Show member pathways Tryptophan catabolism ⁶⁶	11.26	TNF IFNB1 IDO1
25	Cytokines and inflammatory response ⁷⁴	11.09	TNF IL10 IFNB1 CD4
26	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.04	TNF ITGAX ITGAM IL10 IFNB1 CD8A

Sources

GO Terms for Listeriosis

Cellular components related to Listeriosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.77	TNF TLR2 MBL2 ITGAX ITGAM CD4
2	external side of plasma membrane	GO:0009897	9.53	TNF MBL2 ITGAX ITGAM ICOSLG CD8A

Biological processes related to Listeriosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10.02	TNF TLR2 IL10 CD8A CD4 CCR6
2	microglial cell activation	GO:0001774	9.73	ITGAM TLR2 TNF
3	regulation of cytokine production	GO:0001817	9.71	TLR2 IL10 ICOSLG
4	negative regulation of cytokine production involved in immune response	GO:0002719	9.67	TNF IL10
5	response to lipopolysaccharide	GO:0032496	9.5	TNF TLR2 IL10 IFNAR1 IDO1
6	chronic inflammatory response to antigenic stimulus	GO:0002439	9.46	TNF IL10
7	immune system process	GO:0002376	9.23	TLR2 MBL2 KLRG1 ITGAM IDO1 ICOSLG

Molecular functions related to Listeriosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor activity	GO:0038023	9.32	TLR2 KLRG1 ITGAX CD4 CCR6

Sources

Sources for Listeriosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LST001 MIFTS: 58	Listeriosis Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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