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MCID: LST001
MIFTS: 59

Listeriosis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Listeriosis

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MalaCards integrated aliases for Listeriosis:

Name: Listeriosis 12 73 20 58 54 3 44 15 17 70 32
Listeria Infection 12 73 20 58 3
Infection by Listeria Monocytogenes 12
Listeria Monocytogenes Infection 20
Listeria Infections 42

Characteristics:

Orphanet epidemiological data:

58
listeriosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Worldwide),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Gastrointestinal diseases Immune diseases Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


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Summaries for Listeriosis

About this section
GARD : 20 A listeria infection or listeriosis is an infection caused by a bacteria known as Listeria monocytogenes. It mainly affects newborn infants, elderly patients, pregnant women and patients who have low immunity. Listeria can be spread by several methods. A common cause is ingestion (food-borne transmission) of unpasteurized milk or contaminated vegetables. It can also be transmitted from mother to fetus during pregnancy or directly to the newborn at the time of delivery. Listeriosis can cause a variety of symptoms, depending on the person and the part of the body affected. Pregnant women typically have only fever and other flu-like symptoms, such as fatigue and muscle aches. However, infections during pregnancy can lead to miscarriage, stillbirth, premature delivery, or life-threatening infection of the newborn, including generalized infection (sepsis) or inflammation of the membranes that cover the brain ( meningitis ). Sometimes listeriosis involves many organs and presents with masses filled with pus (microabscesses or granulomas). Older children with Listeria infections frequently develop meningitis. Treatment include antibiotics such as ampicillin and aminoglycosides.

MalaCards based summary : Listeriosis, also known as listeria infection, is related to meningoencephalitis and toxoplasmosis, and has symptoms including vomiting, fever and back pain. An important gene associated with Listeriosis is ACTA1 (Actin Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drug Amoxicillin has been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and skin, and related phenotypes are fever and vomiting

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Listeria monocytogenes, which is transmitted by ingestion of contaminated food or raw milk or transmitted by congenital method. Ingestion of Listeria by pregnant women has symptom nausea, has symptom vomiting, has symptom diarrhea, has symptom fever, has symptom malaise, has symptom back pain, and has symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

MedlinePlus : 42 Listeriosis is a foodborne illness caused by Listeria monocytogenes, bacteria found in soil and water. It can be in a variety of raw foods as well as in processed foods and foods made from unpasteurized milk. Listeria is unlike many other germs because it can grow even in the cold temperature of the refrigerator. Symptoms include fever and chills, headache, upset stomach and vomiting. Treatment is with antibiotics. Anyone can get the illness. But it is most likely to affect pregnant women and unborn babies, older adults, and people with weak immune systems. To reduce your risk Use precooked and ready-to-eat foods as soon as you can Avoid raw milk and raw milk products Heat ready-to-eat foods and leftovers until they are steaming hot Wash fresh fruits and vegetables Avoid rare meat and refrigerated smoked seafood Centers for Disease Control and Prevention

CDC : 3 Listeriosis is a serious infection usually caused by eating food contaminated with the bacterium Listeria monocytogenes. An estimated 1,600 people get listeriosis each year, and about 260 die. The infection is most likely to sicken pregnant women and their newborns, adults aged 65 or older, and people with weakened immune systems.

Wikipedia : 73 Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although L.... more...

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Related Diseases for Listeriosis

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Diseases related to Listeriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 728)
# Related Disease Score Top Affiliating Genes
1 meningoencephalitis 31.0 TNF IL6 IL10 CD8A CD4 CCR6
2 toxoplasmosis 30.9 TNF ITGAM IL6 IL10 IDO1
3 chorioamnionitis 30.8 TNF IL6 IL10
4 meningitis 30.8 TNF MBL2 IL6 IL10
5 brucellosis 30.7 TNF IL6 IL10
6 encephalitis 30.7 TNF IL6 IL10 IFNB1 IDO1
7 prosthetic joint infection 30.7 MBL2 IL6
8 bacterial meningitis 30.6 TNF MBL2 IL6 IL10
9 listeria meningitis 30.6 TNF NDUFA9 IFNB1 CD8A
10 gastroenteritis 30.6 TNF IL6 IL10
11 peritonitis 30.5 TNF ITGAM IL6 IL10
12 bronchiolitis obliterans 30.5 TNF IL6 IL10
13 bronchiolitis 30.5 TNF IL6 IL10
14 mast cell neoplasm 30.5 PRF1 ICOSLG H2AC18 CD8A
15 q fever 30.5 TNF MBL2 IL6 IL10
16 cerebritis 30.5 TNF CD8A CD4
17 tularemia 30.4 TNF MBL2 CD8A CD4 CCR6
18 candidiasis 30.4 TNF MBL2 IL6 IL10
19 conjunctivitis 30.4 TNF IL6 IL10
20 vaginitis 30.4 TNF IL6 IL10 CD4 CCR6
21 tetanus 30.4 TNF IL7R IL6 IL10
22 congenital toxoplasmosis 30.4 IL10 CD8A CD4
23 diarrhea 30.4 TNF IL6 IL10 IFNB1
24 granulomatous hepatitis 30.4 TNF CD8A CD4 ACTA1
25 echinococcosis 30.4 TNF IL6 IL10 CD8A
26 salmonellosis 30.3 TNF ITGAX IL6 IL10 CD8A CD4
27 lymphadenitis 30.3 TNF IL10 ICOSLG CD4 CCR6
28 placenta disease 30.3 TNF IL6 H2AC18
29 leishmaniasis 30.3 TNF ITGAM IL6 IL10
30 stomatitis 30.3 TNF IL6 IL10 IFNB1 CD4
31 syphilis 30.3 TNF IL6 CD8A CD4 CCR6
32 ileitis 30.3 TNF IL6 CCR6
33 enterocolitis 30.3 TNF IL6 IL10
34 plague 30.2 TNF IL6 IL10 H2AC18 CD8A CD4
35 pfeiffer syndrome 30.2 PRF1 H2AC18 CD8A CD4 CCR6
36 orchitis 30.2 TNF IL6 IL10 H2AC18 CD8A CD4
37 facial paralysis 30.2 TNF CD8A CD4
38 genital herpes 30.2 IL10 CD8A CD4 CCR6
39 endocarditis 30.2 TNF IL6 IL10
40 choroiditis 30.2 TNF IL10 CD4
41 amebiasis 30.2 TNF IL10 CD4
42 tenosynovitis 30.2 TNF IL6 CD4
43 ulcerative colitis 30.1 TNF IL6 IL10 CCR6
44 allergic disease 30.1 TNF IL6 IL10 ICOSLG CCR6
45 central nervous system disease 30.1 TNF IL6 ICOSLG H2AC18 CCR6
46 rubella 30.1 TNF IL6 IL10 IFNB1
47 crohn's disease 30.1 TNF ITGAX IL6 IL10 ICOSLG CD4
48 typhoid fever 30.1 TNF IL6 CCR6
49 endophthalmitis 30.1 TNF PRF1 IL6
50 subacute sclerosing panencephalitis 30.1 TNF IL6 IL10

Comorbidity relations with Listeriosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Listeriosis:



Diseases related to Listeriosis
Sources

Symptoms & Phenotypes for Listeriosis

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Human phenotypes related to Listeriosis:

58 31 (show top 50) (show all 69)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002013
3 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
4 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
5 meningitis 58 31 frequent (33%) Frequent (79-30%) HP:0001287
6 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
7 nausea 58 31 frequent (33%) Frequent (79-30%) HP:0002018
8 chills 58 31 frequent (33%) Frequent (79-30%) HP:0025143
9 hypoglycorrhachia 58 31 frequent (33%) Frequent (79-30%) HP:0011972
10 increased csf protein 58 31 frequent (33%) Frequent (79-30%) HP:0002922
11 stiff neck 58 31 frequent (33%) Frequent (79-30%) HP:0025258
12 bacteremia 58 31 frequent (33%) Frequent (79-30%) HP:0031864
13 ataxia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001251
14 tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0001337
15 cranial nerve paralysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0006824
16 immunodeficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0002721
17 myoclonus 58 31 occasional (7.5%) Occasional (29-5%) HP:0001336
18 irritability 58 31 occasional (7.5%) Occasional (29-5%) HP:0000737
19 back pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0003418
20 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
21 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
22 premature birth 58 31 occasional (7.5%) Occasional (29-5%) HP:0001622
23 respiratory failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0002878
24 hemiparesis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001269
25 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
26 sensory impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0003474
27 spontaneous abortion 58 31 occasional (7.5%) Occasional (29-5%) HP:0005268
28 loss of consciousness 58 31 occasional (7.5%) Occasional (29-5%) HP:0007185
29 pyelonephritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012330
30 brain abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0030049
31 nuchal rigidity 58 31 occasional (7.5%) Occasional (29-5%) HP:0031179
32 abnormality of the anterior fontanelle 58 31 occasional (7.5%) Occasional (29-5%) HP:0000236
33 seizure 31 occasional (7.5%) HP:0001250
34 intellectual disability 58 31 very rare (1%) Very rare (<4-1%) HP:0001249
35 encephalitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002383
36 hearing impairment 58 31 very rare (1%) Very rare (<4-1%) HP:0000365
37 congestive heart failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001635
38 jaundice 58 31 very rare (1%) Very rare (<4-1%) HP:0000952
39 stroke 58 31 very rare (1%) Very rare (<4-1%) HP:0001297
40 pericarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0001701
41 myocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0012819
42 endocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0100584
43 conjunctivitis 58 31 very rare (1%) Very rare (<4-1%) HP:0000509
44 osteomyelitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002754
45 sepsis 58 31 very rare (1%) Very rare (<4-1%) HP:0100806
46 liver abscess 58 31 very rare (1%) Very rare (<4-1%) HP:0100523
47 cholecystitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001082
48 respiratory distress 58 31 very rare (1%) Very rare (<4-1%) HP:0002098
49 pneumonia 58 31 very rare (1%) Very rare (<4-1%) HP:0002090
50 pustule 58 31 very rare (1%) Very rare (<4-1%) HP:0200039

Symptoms:

12
  • • vomiting
  • • fever
  • • back pain
  • • headache
  • • diarrhea
  • • nausea
  • • malaise

UMLS symptoms related to Listeriosis:


fever; pruritus

MGI Mouse Phenotypes related to Listeriosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CCR6 CD4 CD8A IDO1 IFNB1 IL10
2 immune system MP:0005387 9.77 CCR6 CD4 CD8A IDO1 IFNB1 IL10
3 normal MP:0002873 9.28 CCR6 CD4 CD8A IFNB1 IL10 IL7R
Sources

Drugs & Therapeutics for Listeriosis

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Drugs for Listeriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved 26787-78-0 33613

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicentric Observational National Analysis of Listeriosis and Listeria : Evaluation of the Neurological Consequences of Perinatal Listeriosis Infection Completed NCT02580812
2 Genetic Susceptibility to Listeriosis - Listeria-GEN Recruiting NCT03357536
3 Multicentric Observational NAtional Study on LISteriosis and ListeriA Recruiting NCT01520597
4 Genetic Susceptibility and Biomarkers in Listeriosis (MONALISA-GENBIO) Enrolling by invitation NCT02924220

Search NIH Clinical Center for Listeriosis

Cochrane evidence based reviews: listeriosis

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Genetic Tests for Listeriosis

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Anatomical Context for Listeriosis

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MalaCards organs/tissues related to Listeriosis:

40
T Cells, Bone, Skin, Brain, Liver, Lung, Placenta
Sources

Publications for Listeriosis

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Articles related to Listeriosis:

(show top 50) (show all 4208)
# Title Authors PMID Year
1
An outbreak of human listeriosis associated with frozen sweet corn consumption: Investigations in the UK. 42 61
33279788 2021
2
Receptor-targeted engineered probiotics mitigate lethal Listeria infection. 42 61
33311493 2020
3
CD71+ Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal Mice. 42
33329589 2020
4
Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. 54 61
17111046 2006
5
Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection. 54 61
12517946 2003
6
Listeriolysin and IrpA are major protein targets of the human humoral response against Listeria monocytogenes. 54 61
9284184 1997
7
Prevalence and transmission characteristics of Listeria species from ruminants in farm and slaughtering environments in China. 61
33560938 2021
8
Tolerance of Listeria monocytogenes to biocides used in food processing environments. 61
33653529 2021
9
An ultrasensitive CRISPR/Cas12a based electrochemical biosensor for Listeria monocytogenes detection. 61
33581428 2021
10
Occurrence of Listeria monocytogenes in Counter-Sliced Turkey Meat Samples from Independent Delis in New York City. 61
33211871 2021
11
Characterization of Listeria monocytogenes isolates from lactating dairy cows in a Wisconsin farm: Antibiotic resistance, mammalian cell infection, and effects on the fecal microbiota. 61
33516554 2021
12
Quantifying the bioprotective effect of Lactobacillus sakei CTC494 against Listeria monocytogenes on vacuum packaged hot-smoked sea bream. 61
33279074 2021
13
Alginate-chitosan microcapsules improve vaccine potential of gamma-irradiated Listeria monocytogenes against listeriosis in murine model. 61
33581203 2021
14
Use of Bacteriophage Amended with CRISPR-Cas Systems to Combat Antimicrobial Resistance in the Bacterial Foodborne Pathogen Listeria monocytogenes. 61
33802904 2021
15
Production of Membrane Vesicles in Listeria monocytogenes Cultured with or without Sub-Inhibitory Concentrations of Antibiotics and Their Innate Immune Responses In Vitro. 61
33805671 2021
16
Characterization and In Vitro Efficacy against Listeria monocytogenes of a Newly Isolated Bacteriophage, ɸIZSAM-1. 61
33807487 2021
17
Genetic diversity of Listeria monocytogenes serotype 1/2a strains collected in Brazil by Multi-Virulence-Locus Sequence Typing. 61
33063325 2021
18
Live Imaging Reveals Listeria Hijacking of E-Cadherin Recycling as It Crosses the Intestinal Barrier. 61
33333010 2021
19
Zearalenone and deoxynivalenol inhibited IL-4 receptor-mediated Th2 cell differentiation and aggravated bacterial infection in mice. 61
33556388 2021
20
Proteomics reveals the potential mechanism of Mrps35 controlling Listeria intracellular proliferation in macrophages. 61
33763969 2021
21
Clinical and molecular epidemiology of human listeriosis in Taiwan. 61
33515776 2021
22
Combination Adjuvants Affect the Magnitude of Effector-Like Memory CD8 T Cells and Protection against Listeriosis. 61
33782151 2021
23
Genomic characteristics of listeria monocytogenes causing invasive listeriosis in Japan. 61
33340935 2021
24
The molecular mechanisms of listeriolysin O-induced lipid membrane damage. 61
33722646 2021
25
Listeria spp. Isolated from Tonsils of Wild Deer and Boars: Genomic Characterization. 61
33397708 2021
26
Prevalence of Listeria species on food contact surfaces in Washington State apple packinghouses. 61
33608295 2021
27
Evaluation of avocados as a possible source of Listeria monocytogenes infections, United States, 2016-2019. 61
33592107 2021
28
Innate immune responses to Listeria in vivo. 61
33307408 2021
29
Listeria adhesion protein-expressing bioengineered probiotics prevent fetoplacental transmission of Listeria monocytogenes in a pregnant Guinea pig model. 61
33484805 2021
30
Occurrence, antimicrobial resistance, serotyping and virulence genes of Listeria monocytogenes isolated from foods. 61
33644461 2021
31
Development and Validation of a Quantitative PCR Method for Species Verification and Serogroup Determination of Listeria monocytogenes Isolates. 61
32977330 2021
32
Whole Genome Sequence Analysis of Phage-Resistant Listeria monocytogenes Serotype 1/2a Strains from Turkey Processing Plants. 61
33668492 2021
33
Genetic diversity, biofilm and virulence characteristics of Listeria monocytogenes in salmon sushi. 61
33648189 2021
34
The European Union One Health 2019 Zoonoses Report. 61
33680134 2021
35
Making Sense of the Biodiversity and Virulence of Listeria monocytogenes. 61
33583696 2021
36
Closed Genome Sequences of Clinical Listeria monocytogenes PCR Serogroup IVb Isolates Associated with Two Recent Large Listeriosis Outbreaks in Germany. 61
33541883 2021
37
Utility of rapid tests to assess the prevalence of indicator organisms (Aerobic plate count, Enterobacteriaceae, coliforms, Escherichia coli, and Listeria spp.) in apple packinghouses. 61
33220648 2021
38
Listeria monocytogenes Assessment in a Ready-to-Eat Salad Shelf-Life Study Using Conventional Culture-Based Methods, Genetic Profiling, and Propidium Monoazide Quantitative PCR. 61
33498826 2021
39
MALDI-ToF MS: A Rapid Methodology for Identifying and Subtyping Listeria monocytogenes. 61
32975763 2021
40
Micro/nanoencapsulation strategy to improve the efficiency of natural antimicrobials against Listeria monocytogenes in food products. 61
32323558 2021
41
Analysis of virulence genes and molecular typing of Listeria monocytogenes isolates from human, food, and livestock from 2008 to 2016 in Iran. 61
33454847 2021
42
Epidemiological Characterization of Listeria monocytogenes Infections in Pavia Province in 2017 Reveals the Presence of Multiple Concurrently Circulating Strains. 61
33493413 2021
43
Systemic Listeria monocytogenes infection and concurrent pleural mesothelioma in a cat. 61
33054600 2021
44
Partial Characterization of an Anti-Listerial Bacteriocin from Enterococcus faecium CJNU 2524. 61
33506226 2021
45
Population Genomic Analysis of Listeria monocytogenes From Food Reveals Substrate-Specific Genome Variation. 61
33633707 2021
46
Prevalence and Genetic Diversity of Listeria monocytogenes Isolated From Retail Pork in Wuhan, China. 61
33767677 2021
47
Listeria monocytogenes isolates from Western Cape, South Africa exhibit resistance to multiple antibiotics and contradicts certain global resistance patterns. 61
33659768 2021
48
Identification of Listeria monocytogenes Contamination in a Ready-to-Eat Meat Processing Plant in China. 61
33717016 2021
49
Listeriosis Cases and Genetic Diversity of Their L. monocytogenes Isolates in China, 2008-2019. 61
33680989 2021
50
Listeriosis Caused by Persistence of Listeria monocytogenes Serotype 4b Sequence Type 6 in Cheese Production Environment. 61
33350924 2021
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Variations for Listeriosis

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Expression for Listeriosis

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Search GEO for disease gene expression data for Listeriosis.
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Pathways for Listeriosis

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Pathways related to Listeriosis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.95 TNF MBL2 KLRG1 ITGAX ITGAM IL7R
2
ERK Signaling 63
Show member pathways
 13.79 TNF ITGAX ITGAM IL7R IL6 IL10
3
TGF-Beta Pathway 63
Show member pathways
 13.5 TNF ITGAX ITGAM IL7R IL6 IL10
4
Akt Signaling 63
Show member pathways
 13.34 TNF ITGAX ITGAM IL7R IL6 IL10
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.28 TNF ITGAX ITGAM IL7R IL6 IL10
6
PAK Pathway 63
Show member pathways
 13.26 TNF IL7R IL6 IL10 CD4 CCR6
7
Allograft rejection 36 1
Show member pathways
 12.78 TNF PRF1 IL6 IL10 ICOSLG CD8A
8
nNOS Signaling in Skeletal Muscle 63
Show member pathways
 12.62 TNF PRF1 ITGAX ITGAM ACTA1
9
T cell receptor signaling pathway 36
Show member pathways
 12.54 TNF IL6 IL10 CD8A CD4
10
JAK-STAT signaling pathway 36
Show member pathways
 12.36 IL7R IL6 IL10 IFNB1
11
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.29 TNF IL6 IL10 CCR6
12
NOD-like receptor signaling pathway 36
12.19 TNF PYDC1 IL6 IFNB1
13
Tuberculosis 36
12.17 TNF ITGAX ITGAM IL6 IL10 IFNB1
14
Cell adhesion molecules 36
12.07 ITGAM ICOSLG CD8A CD4
15
Yersinia infection 36
12.02 TNF IL6 IL10 IFNB1 CD8A CD4
16
Interleukin-4 and 13 signaling 65
11.93 TNF ITGAX ITGAM IL6 IL10
17
Amoebiasis 36
11.87 TNF ITGAM IL6 IL10
18
Hematopoietic cell lineage 36
11.84 TNF ITGAM IL7R IL6 CD8A CD4
19
Th1 Differentiation Pathway 64
Show member pathways
 11.71 TNF IL6 IL10 CD4
20
Pertussis 36
11.69 TNF ITGAM IL6 IL10
21
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 TNF ITGAX ITGAM IL7R IL6 IL10
22
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.61 TNF PRF1 CD8A
23
Innate Lymphoid Cell Differentiation Pathways 64
11.6 TNF ITGAM IL7R IL10 CD8A CD4
24
Legionellosis 36
11.57 TNF ITGAM IL6
25
Agrin Interactions at Neuromuscular Junction 63
11.57 ITGAX ITGAM ACTA1
26
IgA-Producing B Cells in the Intestine 64
11.55 TNF KLRG1 IL6 IL10 ICOSLG CCR6
27
Malaria 36
11.5 TNF IL6 IL10
28
Interleukin-10 signaling 65
11.48 TNF IL6 IL10
29
MSP-RON Signaling 63
11.47 TNF ITGAM ACTA1
30
amb2 Integrin signaling 1
11.46 TNF ITGAM IL6
31
Primary immunodeficiency 36
11.34 IL7R CD8A CD4
32
African trypanosomiasis 36
11.33 TNF IL6 IL10 IDO1
33
IL-10 Pathway 63
11.3 TNF IL6 IL10
34
Cytokines and Inflammatory Response 1
11.18 TNF IL6 IL10 IFNB1 CD4
35
Dendritic Cells Developmental Lineage Pathway 64
11.15 TNF ITGAX ITGAM IL7R IL6 IL10
Sources

GO Terms for Listeriosis

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Cellular components related to Listeriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 TNF MBL2 ITGAX ITGAM CD4 CCR6
2 external side of plasma membrane GO:0009897 9.23 TNF ITGAX ITGAM IL7R ICOSLG CD8A

Biological processes related to Listeriosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 TNF ITGAX IL7R IL6 ACTA1
2 immune system process GO:0002376 9.87 MBL2 KLRG1 ITGAM IDO1 ICOSLG CD8A
3 defense response to virus GO:0051607 9.85 PRF1 ITGAX IL6 IFNB1
4 cell surface receptor signaling pathway GO:0007166 9.83 KLRG1 IL7R IFNB1 CD8A CD4
5 response to glucocorticoid GO:0051384 9.74 TNF IL6 IL10
6 positive regulation of interleukin-1 beta production GO:0032731 9.7 TNF PYDC1 IL6
7 cellular defense response GO:0006968 9.67 PRF1 KLRG1 CCR6
8 T cell activation GO:0042110 9.63 ICOSLG CD8A CD4
9 negative regulation of T cell apoptotic process GO:0070233 9.58 IL7R IDO1
10 negative regulation of lipid storage GO:0010888 9.58 TNF IL6
11 B cell proliferation GO:0042100 9.58 IL7R IL10 IFNB1
12 endothelial cell apoptotic process GO:0072577 9.56 TNF IL10
13 defense response to Gram-positive bacterium GO:0050830 9.56 TNF MBL2 IL7R IL6
14 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6
15 positive regulation of JAK-STAT cascade GO:0046427 9.54 TNF IL6 IL10
16 negative regulation of cytokine production involved in immune response GO:0002719 9.51 TNF IL10
17 immune response GO:0006955 9.5 TNF IL7R IL6 IL10 CD8A CD4
18 positive regulation of STAT cascade GO:1904894 9.48 IL7R IL6
19 humoral immune response GO:0006959 9.46 TNF IL6 IFNB1 CCR6
20 cytokine-mediated signaling pathway GO:0019221 9.17 TNF ITGAX ITGAM IL6 IL10 IFNB1

Molecular functions related to Listeriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 IL10 IFNB1
2 signaling receptor activity GO:0038023 8.92 KLRG1 ITGAX CD4 CCR6
Sources

Sources for Listeriosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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