MCID: LST001
MIFTS: 50

Listeriosis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Listeriosis

MalaCards integrated aliases for Listeriosis:

Name: Listeriosis 12 76 53 59 55 3 44 15 73
Listeria Infection 12 76 53 59
Infection by Listeria Monocytogenes 12
Listeria Monocytogenes Infection 53
Listeria Infections 43

Characteristics:

Orphanet epidemiological data:

59
listeriosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Worldwide),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11573
ICD10 33 A32 A32.9
ICD9CM 35 027.0
MeSH 44 D008088
NCIt 50 C82994
SNOMED-CT 68 4241002
Orphanet 59 ORPHA533
MESH via Orphanet 45 D008088
UMLS via Orphanet 74 C0023860
ICD10 via Orphanet 34 A32.0 A32.1 A32.7 more
UMLS 73 C0023860

Summaries for Listeriosis

NIH Rare Diseases : 53 A listeria infection or listeriosis is an infection caused by a bacteria known as Listeria monocytogenes. It mainly affects newborn infants, elderly patients, pregnant women and patients who have low immunity. Listeria can be spread by several methods. A common cause is ingestion (food-borne transmission) of unpasteurized milk or contaminated vegetables. It can also be transmitted from mother to fetus during pregnancy or directly to the newborn at the time of delivery. Listeriosis can cause a variety of symptoms, depending on the person and the part of the body affected. Pregnant women typically have only fever and other flu-like symptoms, such as fatigue and muscle aches. However, infections during pregnancy can lead to miscarriage, stillbirth, premature delivery, or life-threatening infection of the newborn, including generalized infection (sepsis) or inflammation of the membranes that cover the brain (meningitis). Sometimes listeriosis involves many organs and presents with masses filled with pus (microabscesses or granulomas). Older children with Listeria infections frequently develop meningitis.  Treatment include antibiotics such as ampicillin and aminoglycosides.

MalaCards based summary : Listeriosis, also known as listeria infection, is related to meningitis and leukomalacia, and has symptoms including fever, vomiting and back pain. An important gene associated with Listeriosis is ACTA1 (Actin, Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Dendritic Cells Developmental Lineage Pathway. The drugs Amoxicillin and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and liver.

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Listeria monocytogenes, which is transmitted by ingestion of contaminated food or raw milk or transmitted by congenital method. Ingestion of Listeria by pregnant women has symptom nausea, has symptom vomiting, has symptom diarrhea, has symptom fever, has symptom malaise, has symptom back pain, and has symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

MedlinePlus : 43 Listeriosis is a foodborne illness caused by Listeria monocytogenes, bacteria found in soil and water. It can be in a variety of raw foods as well as in processed foods and foods made from unpasteurized milk. Listeria is unlike many other germs because it can grow even in the cold temperature of the refrigerator. Symptoms include fever and chills, headache, upset stomach and vomiting. Treatment is with antibiotics. Anyone can get the illness. But it is most likely to affect pregnant women and unborn babies, older adults, and people with weak immune systems. To reduce your risk Use precooked and ready-to-eat foods as soon as you can Avoid raw milk and raw milk products Heat ready-to-eat foods and leftovers until they are steaming hot Wash fresh fruits and vegetables Avoid rare meat and refrigerated smoked seafood Centers for Disease Control and Prevention

CDC : 3 Listeriosis is a serious infection usually caused by eating food contaminated with the bacterium Listeria monocytogenes. An estimated 1,600 people get listeriosis each year, and about 260 die. The infection is most likely to sicken pregnant women and their newborns, adults aged 65 or older, and people with weakened immune systems.

Wikipedia : 76 Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although... more...

Related Diseases for Listeriosis

Diseases related to Listeriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.2 IL6 MBL2 TNF
2 leukomalacia 30.0 IL6 TNF
3 listeria meningitis 29.9 NDUFA9 TNF
4 chlamydia 29.8 IDO1 IL6 TNF
5 otitis media 29.8 IL6 MBL2 TNF
6 vulvar vestibulitis syndrome 10.2 MBL2 TNF
7 adult dermatomyositis 10.2 MBL2 TNF
8 systemic onset juvenile idiopathic arthritis 10.2 PRF1 TNF
9 trachoma 10.2 IDO1 TNF
10 scorpion envenomation 10.2 IL6 TNF
11 macrophage activation syndrome 10.2 PRF1 TNF
12 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
13 critical limb ischemia 10.2 IL6 TNF
14 streptococcal toxic-shock syndrome 10.2 IL6 TNF
15 juvenile ankylosing spondylitis 10.2 IL6 TNF
16 cardiogenic shock 10.2 IL6 TNF
17 null-cell leukemia 10.2 IL6 TNF
18 retinitis pigmentosa 55 10.2 IL6 TNF
19 salmonellosis 10.2
20 toxoplasmosis 10.2
21 anca-associated vasculitis 10.2 IL6 TNF
22 glossitis 10.2 IL6 TNF
23 laryngitis 10.2 IL6 TNF
24 mannose-binding lectin deficiency 10.2 IL6 MBL2
25 anterior uveitis 10.2 IL6 TNF
26 acute vascular insufficiency of intestine 10.2 IL6 TNF
27 posterior urethral valves 10.2 IL6 TNF
28 osteosclerotic myeloma 10.2 IL6 TNF
29 poems syndrome 10.1 IL6 TNF
30 blood group, globoside system 10.1 IL6 PRF1
31 periapical periodontitis 10.1 IL6 TNF
32 autoimmune gastritis 10.1 IL6 TNF
33 meconium aspiration syndrome 10.1 IL6 TNF
34 burning mouth syndrome 10.1 IL6 TNF
35 streptococcal meningitis 10.1 MBL2 TNF
36 trypanosomiasis 10.1 IDO1 IL6 TNF
37 central nervous system vasculitis 10.1 IL6 TNF
38 bacterial infectious disease 10.1 IL6 MBL2 TNF
39 rheumatic fever 10.1 IL6 MBL2 TNF
40 rheumatic heart disease 10.1 IL6 MBL2 TNF
41 cerebral palsy 10.1 IL6 MBL2 TNF
42 crohn's colitis 10.1 CDH1 TNF
43 stachybotrys chartarum 10.1 IL6 TNF
44 kawasaki disease 10.1 IL6 MBL2 TNF
45 louse-borne relapsing fever 10.1 IL6 TNF
46 pneumonia 10.1 IL6 MBL2 TNF
47 endometrial disease 10.1 IL6 TNF
48 hepatitis 10.1
49 behcet syndrome 10.1 IL6 MBL2 TNF
50 systemic lupus erythematosus 10.0

Comorbidity relations with Listeriosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Listeriosis:



Diseases related to Listeriosis

Symptoms & Phenotypes for Listeriosis

Symptoms:

12
  • fever
  • vomiting
  • back pain
  • diarrhea
  • headache
  • nausea
  • malaise

UMLS symptoms related to Listeriosis:


fever, pruritus

Drugs & Therapeutics for Listeriosis

Drugs for Listeriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved 26787-78-0 33613
2
Infliximab Approved 170277-31-3
3 Anti-Bacterial Agents
4 Anti-Infective Agents
5 Gastrointestinal Agents
6 Dermatologic Agents
7 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence, Risk Factors and Impact on Renal Function of the Appearance of Crystalluria Under High-dose Intravenous Amoxicillin Completed NCT02853292
2 Postmarketing Safety Surveillance European Registry of Crohn's Disease Patients Treated With Remicade or Standard Therapy (MK-2155-035) Completed NCT00705614
3 Genetic Susceptibility to Listeriosis Recruiting NCT03357536 Not Applicable
4 National Study on Listeriosis and Listeria Recruiting NCT01520597
5 Neurological Consequences of Perinatal Listeriosis Infection Recruiting NCT02580812 Not Applicable
6 Genetic Susceptibility and Biomarkers in Listeriosis Enrolling by invitation NCT02924220

Search NIH Clinical Center for Listeriosis

Cochrane evidence based reviews: listeriosis

Genetic Tests for Listeriosis

Anatomical Context for Listeriosis

MalaCards organs/tissues related to Listeriosis:

41
T Cells, Brain, Liver, Neutrophil, Lymph Node, Bone, B Cells

Publications for Listeriosis

Articles related to Listeriosis:

(show top 50) (show all 1110)
# Title Authors Year
1
Genomic Characterization of Listeria monocytogenes Isolates Associated with Clinical Listeriosis and the Food Production Environment in Ireland. ( 29558450 )
2018
2
The case of septical form of listeriosis with numerous abscesses of liver ( 29667380 )
2018
3
Listeriosis Outbreaks Associated with Soft Cheeses, United States, 1998-2014<sup>1</sup>. ( 29774843 )
2018
4
Increasing Incidence of Listeriosis and Infection-associated Clinical Outcomes. ( 29214753 )
2018
5
Awareness of Listeriosis and Methylmercury toxicity public health recommendations and diet during pregnancy. ( 29678412 )
2018
6
Invasive Listeriosis of Intracardiac Device. ( 29849653 )
2018
7
Septicemic listeriosis: An emerging food-borne illness in India? ( 29735848 )
2018
8
A Comparison of Oral and Intravenous Mouse Models of Listeriosis. ( 29361677 )
2018
9
Listeriosis in pregnancy: under-diagnosis despite over-treatment. ( 29022924 )
2018
10
Implicated Food Products for Listeriosis and Changes in Serovars of Listeria monocytogenes Affecting Humans in Recent Decades. ( 29958028 )
2018
11
Surveillance of listeriosis in the Tel Aviv District, Israel, 2010-2015. ( 29307320 )
2018
12
Neonatal Listeriosis and The Importance of Body Surface Cultures. ( 29589345 )
2018
13
Campylobacteriosis, Salmonellosis, Yersiniosis, and Listeriosis as Zoonotic Foodborne Diseases: A Review. ( 29701663 )
2018
14
Genomic and phenotypic diversity of Listeria monocytogenes clonal complexes associated with human listeriosis. ( 29500754 )
2018
15
Genetic characterization of Listeria monocytogenes from ruminant listeriosis from different geographical regions in the U.S. ( 29290393 )
2018
16
Clinical management of women with listeriosis risk during pregnancy: a review of national guidelines. ( 29237320 )
2018
17
An outbreak of listeriosis linked to turkey meat products in the Czech Republic, 2012-2016. ( 29909819 )
2018
18
Erratum: Increasing Incidence of Listeriosis and Infection associated Clinical Outcomes. ( 29401569 )
2018
19
Listeriosis during the period 2003-2016. ( 29739228 )
2018
20
Whole-Genome Sequences of Two Listeria monocytogenes Serovar 1/2a Strains Responsible for a Severe Listeriosis Outbreak in Central Italy. ( 29903806 )
2018
21
Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases. ( 29372499 )
2018
22
Neuroinvasive Listeriosis: Could Petechial Hemorrhages be a Diagnostic Clue? ( 29722741 )
2018
23
Challenging management of chorioamnionitis with placental listeriosis: lessons from 2 cases. ( 30474016 )
2018
24
Draft Genome Sequences of 510 Listeria monocytogenes Strains from Food Isolates and Human Listeriosis Cases from Northern Italy. ( 29348329 )
2018
25
How climate change can fuel listeriosis outbreaks in South Africa. ( 30004323 )
2018
26
A severe outbreak of listeriosis in central Italy with a rare pulsotype associated with processed pork products. ( 30024370 )
2018
27
Listeriosis in Pregnancy: Practitioners' Food Safety Counselling Practices to Pregnant Women. ( 30030057 )
2018
28
Serotype to genotype: The changing landscape of listeriosis outbreak investigations. ( 30056958 )
2018
29
Retrospective validation of whole genome sequencing-enhanced surveillance of listeriosis in Europe, 2010 to 2015. ( 30131096 )
2018
30
Pregnancy-related listeriosis: frequency and genotypic characteristics of L. monocytogenes from human specimens in Kerman, Iran. ( 30178426 )
2018
31
Nutrition and listeriosis during pregnancy: a systematic review. ( 30275948 )
2018
32
Neonatal listeriosis during a countrywide epidemic in South Africa: A tertiary hospital's experience. ( 30421708 )
2018
33
Listeriosis in fattening pigs caused by poor quality silage - a case report. ( 30463612 )
2018
34
Mortality risk factors for listeriosis - A 10 year review of non-pregnancy associated cases in England 2006-2015. ( 30528872 )
2018
35
IFN-Gamma-Dependent and Independent Mechanisms of CD4⁺ Memory T Cell-Mediated Protection from Listeria Infection. ( 29438281 )
2018
36
The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection. ( 29902442 )
2018
37
Genomic Characterization Helps Dissecting an Outbreak of Listeriosis in Northern Italy. ( 28856063 )
2017
38
Burden of salmonellosis, campylobacteriosis and listeriosis: a time series analysis, Belgium, 2012 to 2020. ( 28935025 )
2017
39
Listeriosis in two twin pregnancies after in vitro fertilization with differential outcome and literature review. ( 29179588 )
2017
40
Epidemiology and Molecular Typing of Pregnancy-Associated Listeriosis Cases in Lombardy, Italy, over a 10-Year Period (2005-2014). ( 28408795 )
2017
41
Comparative diagnostic efficacy of recombinant LLO and PI-PLC-based ELISAs for detection of listeriosis in animals. ( 28411150 )
2017
42
Changing US Population Demographics: What Does This Mean for Listeriosis Incidence and Exposure? ( 28632414 )
2017
43
Human Listeriosis Presenting as Breast Abscess: Report of a Rare Case. ( 28289572 )
2017
44
Epidemiology and treatment of the commonest form of listeriosis: meningitis and bacteraemia. ( 28956537 )
2017
45
Spontaneous listeriosis in grey mouse lemurs (Microcebus murinus), but not in Goodman's mouse lemurs (Microcebus lehilahytsara) of the same colony. ( 28888657 )
2017
46
Cross-border outbreak of listeriosis caused by cold-smoked salmon, revealed by integrated surveillance and whole genome sequencing (WGS), Denmark and France, 2015 to 2017. ( 29258647 )
2017
47
Pregnancy-related listeriosis. ( 28398675 )
2017
48
Corrigendum for: Pregnancy-related Listeriosis. ( 28861948 )
2017
49
A clade of Listeria monocytogenes serotype 4b variant strains linked to recent listeriosis outbreaks associated with produce from a defined geographic region in the US. ( 28464038 )
2017
50
A nationwide outbreak of listeriosis associated with cold-cuts, Sweden 2013-2014. ( 28649304 )
2017

Variations for Listeriosis

Expression for Listeriosis

Search GEO for disease gene expression data for Listeriosis.

Pathways for Listeriosis

Pathways related to Listeriosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.72 CDH1 IL6 TNF
2 11 CDH1 IL6 TNF
3 10.6 IL6 TNF
4 10.43 IL6 TNF
5 10.34 IDO1 IL6 TNF

GO Terms for Listeriosis

Biological processes related to Listeriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 IDO1 IL6 LXN TNF
2 negative regulation of neurogenesis GO:0050768 9.43 IL6 TNF
3 positive regulation of chemokine production GO:0032722 9.4 IL6 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.33 IL6 MBL2 TNF
5 positive regulation of glial cell proliferation GO:0060252 9.32 IL6 TNF
6 negative regulation of growth of symbiont in host GO:0044130 9.26 MBL2 TNF
7 negative regulation of lipid storage GO:0010888 8.96 IL6 TNF
8 positive regulation of neuroinflammatory response GO:0150078 8.62 IL6 TNF

Sources for Listeriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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