MCID: LST001
MIFTS: 50

Listeriosis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Listeriosis

MalaCards integrated aliases for Listeriosis:

Name: Listeriosis 12 77 54 60 56 3 45 15 17 74
Listeria Infection 12 77 54 60
Infection by Listeria Monocytogenes 12
Listeria Monocytogenes Infection 54
Listeria Infections 44

Characteristics:

Orphanet epidemiological data:

60
listeriosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Worldwide),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11573
ICD9CM 36 027.0
MeSH 45 D008088
NCIt 51 C82994
SNOMED-CT 69 4241002
ICD10 34 A32 A32.9
MESH via Orphanet 46 D008088
ICD10 via Orphanet 35 A32.0 A32.1 A32.7 more
UMLS via Orphanet 75 C0023860
Orphanet 60 ORPHA533
UMLS 74 C0023860

Summaries for Listeriosis

NIH Rare Diseases : 54 A listeria infection or listeriosis is an infection caused by a bacteria known as Listeria monocytogenes. It mainly affects newborn infants, elderly patients, pregnant women and patients who have low immunity. Listeria can be spread by several methods. A common cause is ingestion (food-borne transmission) of unpasteurized milk or contaminated vegetables. It can also be transmitted from mother to fetus during pregnancy or directly to the newborn at the time of delivery. Listeriosis can cause a variety of symptoms, depending on the person and the part of the body affected. Pregnant women typically have only fever and other flu-like symptoms, such as fatigue and muscle aches. However, infections during pregnancy can lead to miscarriage, stillbirth, premature delivery, or life-threatening infection of the newborn, including generalized infection (sepsis) or inflammation of the membranes that cover the brain (meningitis). Sometimes listeriosis involves many organs and presents with masses filled with pus (microabscesses or granulomas). Older children with Listeria infections frequently develop meningitis.  Treatment include antibiotics such as ampicillin and aminoglycosides.

MalaCards based summary : Listeriosis, also known as listeria infection, is related to meningitis and listeria meningitis, and has symptoms including fever, vomiting and back pain. An important gene associated with Listeriosis is ACTA1 (Actin Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Dendritic Cells Developmental Lineage Pathway. The drugs Amoxicillin and Ampicillin have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and liver.

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Listeria monocytogenes, which is transmitted by ingestion of contaminated food or raw milk or transmitted by congenital method. Ingestion of Listeria by pregnant women has symptom nausea, has symptom vomiting, has symptom diarrhea, has symptom fever, has symptom malaise, has symptom back pain, and has symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

MedlinePlus : 44 Listeriosis is a foodborne illness caused by Listeria monocytogenes, bacteria found in soil and water. It can be in a variety of raw foods as well as in processed foods and foods made from unpasteurized milk. Listeria is unlike many other germs because it can grow even in the cold temperature of the refrigerator. Symptoms include fever and chills, headache, upset stomach and vomiting. Treatment is with antibiotics. Anyone can get the illness. But it is most likely to affect pregnant women and unborn babies, older adults, and people with weak immune systems. To reduce your risk Use precooked and ready-to-eat foods as soon as you can Avoid raw milk and raw milk products Heat ready-to-eat foods and leftovers until they are steaming hot Wash fresh fruits and vegetables Avoid rare meat and refrigerated smoked seafood Centers for Disease Control and Prevention

CDC : 3 Get answers to commonly asked questions about Listeria

Wikipedia : 77 Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although... more...

Related Diseases for Listeriosis

Diseases related to Listeriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 meningitis 30.6 IL6 MBL2 TNF
2 listeria meningitis 30.3 NDUFA9 TNF
3 leukomalacia 30.2 IL6 TNF
4 chlamydia 30.0 IDO1 IL6 TNF
5 otitis media 30.0 IL6 MBL2 TNF
6 vulvar vestibulitis syndrome 10.4 MBL2 TNF
7 adult dermatomyositis 10.4 MBL2 TNF
8 trachoma 10.4 IDO1 TNF
9 scorpion envenomation 10.3 IL6 TNF
10 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
11 autoimmune myocarditis 10.3 IL6 TNF
12 critical limb ischemia 10.3 IL6 TNF
13 streptococcal toxic-shock syndrome 10.3 IL6 TNF
14 juvenile ankylosing spondylitis 10.3 IL6 TNF
15 cardiogenic shock 10.3 IL6 TNF
16 null-cell leukemia 10.3 IL6 TNF
17 retinitis pigmentosa 55 10.3 IL6 TNF
18 glossitis 10.3 IL6 TNF
19 laryngitis 10.3 IL6 TNF
20 mannose-binding lectin deficiency 10.3 IL6 MBL2
21 acute vascular insufficiency of intestine 10.3 IL6 TNF
22 posterior urethral valves 10.3 IL6 TNF
23 salmonellosis 10.3
24 osteosclerotic myeloma 10.2 IL6 TNF
25 poems syndrome 10.2 IL6 TNF
26 toxoplasmosis 10.2
27 periapical periodontitis 10.2 IL6 TNF
28 autoimmune gastritis 10.2 IL6 TNF
29 meconium aspiration syndrome 10.2 IL6 TNF
30 systemic onset juvenile idiopathic arthritis 10.2 PRF1 TNF
31 burning mouth syndrome 10.2 IL6 TNF
32 streptococcal meningitis 10.2 MBL2 TNF
33 trypanosomiasis 10.2 IDO1 IL6 TNF
34 hairy cell leukemia 10.2
35 central nervous system vasculitis 10.2 IL6 TNF
36 rheumatic fever 10.2 IL6 MBL2 TNF
37 rheumatic heart disease 10.2 IL6 MBL2 TNF
38 cerebral palsy 10.2 IL6 MBL2 TNF
39 stachybotrys chartarum 10.2 IL6 TNF
40 kawasaki disease 10.2 IL6 MBL2 TNF
41 bacterial infectious disease 10.2 IL6 MBL2 TNF
42 louse-borne relapsing fever 10.2 IL6 TNF
43 macrophage activation syndrome 10.2 PRF1 TNF
44 pneumonia 10.1 IL6 MBL2 TNF
45 endometrial disease 10.1 IL6 TNF
46 hepatitis 10.1
47 behcet syndrome 10.1 IL6 MBL2 TNF
48 blood group, globoside system 10.0 IL6 PRF1
49 leukemia 10.0
50 lymphocytic leukemia 10.0

Comorbidity relations with Listeriosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Listeriosis:



Diseases related to Listeriosis

Symptoms & Phenotypes for Listeriosis

Symptoms:

12
  • fever
  • vomiting
  • back pain
  • headache
  • diarrhea
  • nausea
  • malaise

UMLS symptoms related to Listeriosis:


fever, pruritus

Drugs & Therapeutics for Listeriosis

Drugs for Listeriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved 26787-78-0 33613
2
Ampicillin Approved, Vet_approved 69-53-4 6249
3
Infliximab Approved 170277-31-3
4 Anti-Bacterial Agents
5 Anti-Infective Agents
6 Gastrointestinal Agents
7 Dermatologic Agents
8 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence, Risk Factors and Impact on Renal Function of the Appearance of Crystalluria Under High-dose Intravenous Amoxicillin Completed NCT02853292
2 Successful Treatment of Maternal Listeria Monocytogenes Bacteremia in the First Trimester Completed NCT03248973 Ampicillin Injection
3 Postmarketing Safety Surveillance European Registry of Crohn's Disease Patients Treated With Remicade or Standard Therapy (MK-2155-035) Completed NCT00705614
4 Genetic Susceptibility to Listeriosis Recruiting NCT03357536 Not Applicable
5 National Study on Listeriosis and Listeria Recruiting NCT01520597
6 Neurological Consequences of Perinatal Listeriosis Infection Recruiting NCT02580812 Not Applicable
7 Genetic Susceptibility and Biomarkers in Listeriosis Enrolling by invitation NCT02924220

Search NIH Clinical Center for Listeriosis

Cochrane evidence based reviews: listeriosis

Genetic Tests for Listeriosis

Anatomical Context for Listeriosis

MalaCards organs/tissues related to Listeriosis:

42
T Cells, Brain, Liver, Bone, Neutrophil, Bone Marrow, B Cells

Publications for Listeriosis

Articles related to Listeriosis:

(show top 50) (show all 1299)
# Title Authors Year
1
Differences Among Incidence Rates of Invasive Listeriosis in the U.S. FoodNet Population by Age, Sex, Race/Ethnicity, and Pregnancy Status, 2008-2016. ( 30735066 )
2019
2
Investigation of Listeriosis-Related Knowledge, Attitudes, and Practices Among Medical Staff in Fangshan, Beijing, China. ( 31099593 )
2019
3
LISTERIA MENINGITIS IN DANISH CHILDREN 2000-2017: A Rare Event Even in a Country With High Rates of Invasive Listeriosis. ( 31107421 )
2019
4
Awareness of Listeriosis and Methylmercury toxicity public health recommendations and diet during pregnancy. ( 29678412 )
2019
5
A potential bio-control agent from baical skullcap root against listeriosis via the inhibition of sortase A and listeriolysin O. ( 30585434 )
2019
6
Listeriosis in mainland China: A systematic review. ( 30641204 )
2019
7
Shared genome analyses of notable listeriosis outbreaks, highlighting the critical importance of epidemiological evidence, input datasets and interpretation criteria. ( 30648944 )
2019
8
Notes from the Field: Outbreak of Listeriosis Likely Associated with Prepackaged Caramel Apples - United States, 2017. ( 30677010 )
2019
9
Utility of Whole Genome Sequencing To Describe the Persistence and Evolution of Listeria monocytogenes Strains within Crabmeat Processing Environments Linked to Two Outbreaks of Listeriosis. ( 30702931 )
2019
10
Immunohistochemical evaluation of natural cases of encephalitic listeriosis in sheep. ( 30729816 )
2019
11
Campylobacteriosis, Salmonellosis, Yersiniosis, and Listeriosis as Zoonotic Foodborne Diseases: A Review. ( 29701663 )
2018
12
Challenging management of chorioamnionitis with placental listeriosis: lessons from 2 cases. ( 30474016 )
2018
13
Late stillbirth due to listeriosis. ( 30775326 )
2018
14
Listeriosis in pregnancy: under-diagnosis despite over-treatment. ( 29022924 )
2018
15
Increasing Incidence of Listeriosis and Infection-associated Clinical Outcomes. ( 29214753 )
2018
16
Clinical management of women with listeriosis risk during pregnancy: a review of national guidelines. ( 29237320 )
2018
17
Genetic characterization of Listeria monocytogenes from ruminant listeriosis from different geographical regions in the U.S. ( 29290393 )
2018
18
Surveillance of listeriosis in the Tel Aviv District, Israel, 2010-2015. ( 29307320 )
2018
19
Draft Genome Sequences of 510 Listeria monocytogenes Strains from Food Isolates and Human Listeriosis Cases from Northern Italy. ( 29348329 )
2018
20
A Comparison of Oral and Intravenous Mouse Models of Listeriosis. ( 29361677 )
2018
21
Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases. ( 29372499 )
2018
22
Erratum: Increasing Incidence of Listeriosis and Infection associated Clinical Outcomes. ( 29401569 )
2018
23
Genomic and phenotypic diversity of Listeria monocytogenes clonal complexes associated with human listeriosis. ( 29500754 )
2018
24
Genomic Characterization of Listeria monocytogenes Isolates Associated with Clinical Listeriosis and the Food Production Environment in Ireland. ( 29558450 )
2018
25
Neonatal Listeriosis and The Importance of Body Surface Cultures. ( 29589345 )
2018
26
The case of septical form of listeriosis with numerous abscesses of liver ( 29667380 )
2018
27
Neuroinvasive Listeriosis: Could Petechial Hemorrhages be a Diagnostic Clue? ( 29722741 )
2018
28
Septicemic listeriosis: An emerging food-borne illness in India? ( 29735848 )
2018
29
Listeriosis during the period 2003-2016. ( 29739228 )
2018
30
Listeriosis Outbreaks Associated with Soft Cheeses, United States, 1998-20141. ( 29774843 )
2018
31
Invasive Listeriosis of Intracardiac Device. ( 29849653 )
2018
32
Whole-Genome Sequences of Two Listeria monocytogenes Serovar 1/2a Strains Responsible for a Severe Listeriosis Outbreak in Central Italy. ( 29903806 )
2018
33
An outbreak of listeriosis linked to turkey meat products in the Czech Republic, 2012-2016. ( 29909819 )
2018
34
Implicated Food Products for Listeriosis and Changes in Serovars of Listeria monocytogenes Affecting Humans in Recent Decades. ( 29958028 )
2018
35
How climate change can fuel listeriosis outbreaks in South Africa. ( 30004323 )
2018
36
A severe outbreak of listeriosis in central Italy with a rare pulsotype associated with processed pork products. ( 30024370 )
2018
37
Listeriosis in Pregnancy: Practitioners' Food Safety Counselling Practices to Pregnant Women. ( 30030057 )
2018
38
Serotype to genotype: The changing landscape of listeriosis outbreak investigations. ( 30056958 )
2018
39
Retrospective validation of whole genome sequencing-enhanced surveillance of listeriosis in Europe, 2010 to 2015. ( 30131096 )
2018
40
Pregnancy-related listeriosis: frequency and genotypic characteristics of L. monocytogenes from human specimens in Kerman, Iran. ( 30178426 )
2018
41
Nutrition and listeriosis during pregnancy: a systematic review. ( 30275948 )
2018
42
Neonatal listeriosis during a countrywide epidemic in South Africa: A tertiary hospital's experience. ( 30421708 )
2018
43
Listeriosis in fattening pigs caused by poor quality silage - a case report. ( 30463612 )
2018
44
Mortality risk factors for listeriosis - A 10 year review of non-pregnancy associated cases in England 2006-2015. ( 30528872 )
2018
45
A review of listeriosis notifications and co-existing conditions in New South Wales, 2010-2015. ( 30626293 )
2018
46
Simultaneous CMV and Listeria infection following alemtuzumab treatment for multiple sclerosis. ( 30587519 )
2018
47
IFN-Gamma-Dependent and Independent Mechanisms of CD4⁺ Memory T Cell-Mediated Protection from Listeria Infection. ( 29438281 )
2018
48
The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection. ( 29902442 )
2018
49
Human Listeriosis Presenting as Breast Abscess: Report of a Rare Case. ( 28289572 )
2017
50
Burden of salmonellosis, campylobacteriosis and listeriosis: a time series analysis, Belgium, 2012 to 2020. ( 28935025 )
2017

Variations for Listeriosis

Expression for Listeriosis

Search GEO for disease gene expression data for Listeriosis.

Pathways for Listeriosis

Pathways related to Listeriosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.72 CDH1 IL6 TNF
2 11 CDH1 IL6 TNF
3 10.6 IL6 TNF
4 10.43 IL6 TNF
5 10.37 IDO1 IL6 TNF

GO Terms for Listeriosis

Biological processes related to Listeriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neurogenesis GO:0050768 9.4 IL6 TNF
2 positive regulation of chemokine production GO:0032722 9.37 IL6 TNF
3 defense response to Gram-positive bacterium GO:0050830 9.33 IL6 MBL2 TNF
4 positive regulation of glial cell proliferation GO:0060252 9.32 IL6 TNF
5 negative regulation of growth of symbiont in host GO:0044130 9.26 MBL2 TNF
6 negative regulation of lipid storage GO:0010888 8.96 IL6 TNF
7 positive regulation of neuroinflammatory response GO:0150078 8.62 IL6 TNF

Sources for Listeriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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