MCID: LST001
MIFTS: 54

Listeriosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Listeriosis

MalaCards integrated aliases for Listeriosis:

Name: Listeriosis 12 76 53 59 55 3 44 15 73
Listeria Infection 12 76 53 59
Infection by Listeria Monocytogenes 12
Listeria Monocytogenes Infection 53
Listeria Infections 43

Characteristics:

Orphanet epidemiological data:

59
listeriosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Worldwide),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11573
ICD10 33 A32 A32.9
ICD9CM 35 027.0
MeSH 44 D008088
NCIt 50 C82994
Orphanet 59 ORPHA533
MESH via Orphanet 45 D008088
UMLS via Orphanet 74 C0023860
ICD10 via Orphanet 34 A32.0 A32.1 A32.7 more
UMLS 73 C0023860

Summaries for Listeriosis

NIH Rare Diseases : 53 A listeria infection or listeriosis is an infection caused by a bacteria known as Listeria monocytogenes. It mainly affects newborn infants, elderly patients, pregnant women and patients who have low immunity. Listeria can be spread by several methods. A common cause is ingestion (food-borne transmission) of unpasteurized milk or contaminated vegetables. It can also be transmitted from mother to fetus during pregnancy or directly to the newborn at the time of delivery. Listeriosis can cause a variety of symptoms, depending on the person and the part of the body affected. Pregnant women typically have only fever and other flu-like symptoms, such as fatigue and muscle aches. However, infections during pregnancy can lead to miscarriage, stillbirth, premature delivery, or life-threatening infection of the newborn, including generalized infection (sepsis) or inflammation of the membranes that cover the brain (meningitis). Sometimes listeriosis involves many organs and presents with masses filled with pus (microabscesses or granulomas). Older children with Listeria infections frequently develop meningitis.  Treatment include antibiotics such as ampicillin and aminoglycosides.

MalaCards based summary : Listeriosis, also known as listeria infection, is related to leukomalacia and toxoplasmosis, and has symptoms including nausea, vomiting and diarrhea. An important gene associated with Listeriosis is ACTA1 (Actin, Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Apoptosis and survival Caspase cascade. The drugs Amoxicillin and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and liver, and related phenotypes are integument and liver/biliary system

MedlinePlus : 43 Listeriosis is a foodborne illness caused by Listeria monocytogenes, bacteria found in soil and water. It can be in a variety of raw foods as well as in processed foods and foods made from unpasteurized milk. Listeria is unlike many other germs because it can grow even in the cold temperature of the refrigerator. Symptoms include fever and chills, headache, upset stomach and vomiting. Treatment is with antibiotics. Anyone can get the illness. But it is most likely to affect pregnant women and unborn babies, older adults, and people with weak immune systems. To reduce your risk Use precooked and ready-to-eat foods as soon as you can Avoid raw milk and raw milk products Heat ready-to-eat foods and leftovers until they are steaming hot Wash fresh fruits and vegetables Avoid rare meat and refrigerated smoked seafood Centers for Disease Control and Prevention

CDC : 3 Get answers to commonly asked questions about Listeria

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Listeria monocytogenes, which is transmitted by ingestion of contaminated food or raw milk or transmitted by congenital method. Ingestion of Listeria by pregnant women has symptom nausea, has symptom vomiting, has symptom diarrhea, has symptom fever, has symptom malaise, has symptom back pain, and has symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

Wikipedia : 76 Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although... more...

Related Diseases for Listeriosis

Diseases related to Listeriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 leukomalacia 30.6 IL6 TNF
2 toxoplasmosis 30.5 IL10 IL6 TNF
3 listeria meningitis 30.0 NDUFA9 TNF
4 cytomegalovirus infection 30.0 IL10 IL6 TNF
5 brucellosis 30.0 IL10 IL6 TNF
6 meningitis 29.9 IL10 IL6 MBL2 TNF
7 connective tissue disease 29.9 IL10 IL6 TNF
8 gastroenteritis 29.7 CDH1 IL10 IL6 TNF
9 chlamydia 29.6 IDO1 IL10 IL6 TNF
10 colitis 29.6 IL10 IL6 TNF
11 otitis media 29.5 IL10 IL6 MBL2 TNF
12 multiple sclerosis 29.2 IL10 IL6 PRF1 TNF
13 scorpion envenomation 10.8 IL6 TNF
14 systemic onset juvenile idiopathic arthritis 10.8 PRF1 TNF
15 vulvar vestibulitis syndrome 10.8 MBL2 TNF
16 angioimmunoblastic lymphadenopathy with dysproteinemia 10.8 IL6 TNF
17 punctate inner choroidopathy 10.8 IL10 TNF
18 adult dermatomyositis 10.8 MBL2 TNF
19 tropical endomyocardial fibrosis 10.7 IL10 TNF
20 critical limb ischemia 10.7 IL6 TNF
21 streptococcal toxic-shock syndrome 10.7 IL6 TNF
22 null-cell leukemia 10.7 IL6 TNF
23 microscopic polyangiitis 10.7 IL10 TNF
24 multifocal choroiditis 10.7 IL10 TNF
25 tungiasis 10.7 IL10 TNF
26 endomyocardial fibrosis 10.7 IL10 TNF
27 retinitis pigmentosa 55 10.7 IL6 TNF
28 transient hypogammaglobulinemia 10.6 IL10 TNF
29 anca-associated vasculitis 10.6 IL6 TNF
30 mannose-binding lectin deficiency 10.6 IL6 MBL2
31 laryngitis 10.6 IL6 TNF
32 macrophage activation syndrome 10.6 PRF1 TNF
33 scabies 10.6 IL10 MBL2
34 choroiditis 10.6 IL10 TNF
35 eye lymphoma 10.5 IL10 IL6
36 acute vascular insufficiency of intestine 10.5 IL6 TNF
37 acute transverse myelitis 10.5 IL10 IL6
38 posterior urethral valves 10.5 IL6 TNF
39 idiopathic achalasia 10.5 IL10 TNF
40 mucocutaneous leishmaniasis 10.5 IL10 TNF
41 trichuriasis 10.5 IDO1 IL10 TNF
42 trachoma 10.5 IDO1 IL10 TNF
43 poems syndrome 10.5 IL6 TNF
44 funisitis 10.4 IL10 IL6
45 clonorchiasis 10.4 IL10 TNF
46 microscopic colitis 10.4 IL6 TNF
47 crohn's colitis 10.4 CDH1 TNF
48 transverse myelitis 10.4 IL10 IL6 TNF
49 pulmonary tuberculosis 10.4 IL10 MBL2 TNF
50 intermediate uveitis 10.4 IL10 IL6 TNF

Comorbidity relations with Listeriosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Listeriosis:



Diseases related to Listeriosis

Symptoms & Phenotypes for Listeriosis

Symptoms:

12
  • nausea
  • vomiting
  • diarrhea
  • fever
  • malaise
  • back pain
  • headache

UMLS symptoms related to Listeriosis:


fever, pruritus

MGI Mouse Phenotypes related to Listeriosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.7 TNF CDH1 IL10 IL6 LIPI LXN
2 liver/biliary system MP:0005370 9.43 TNF ACTA1 IL10 IL6 LIPI PRF1
3 reproductive system MP:0005389 9.17 PRF1 TNF ACTA1 CDH1 IDO1 IL10

Drugs & Therapeutics for Listeriosis

Drugs for Listeriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved 26787-78-0 33613
2
Infliximab Approved 170277-31-3
3 Anti-Bacterial Agents
4 Anti-Infective Agents
5 Antirheumatic Agents
6 Dermatologic Agents
7 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Incidence, Risk Factors and Impact on Renal Function of the Appearance of Crystalluria Under High-dose Intravenous Amoxicillin Completed NCT02853292
2 Postmarketing Safety Surveillance European Registry of Crohn's Disease Patients Treated With Remicade or Standard Therapy (MK-2155-035) Completed NCT00705614
3 Genetic Susceptibility to Listeriosis Recruiting NCT03357536 Not Applicable
4 National Study on Listeriosis and Listeria Recruiting NCT01520597
5 Neurological Consequences of Perinatal Listeriosis Infection Recruiting NCT02580812 Not Applicable
6 Genetic Susceptibility and Biomarkers in Listeriosis Enrolling by invitation NCT02924220

Search NIH Clinical Center for Listeriosis

Cochrane evidence based reviews: listeriosis

Genetic Tests for Listeriosis

Anatomical Context for Listeriosis

MalaCards organs/tissues related to Listeriosis:

41
Brain, T Cells, Liver, Bone, Neutrophil, Bone Marrow, Placenta

Publications for Listeriosis

Articles related to Listeriosis:

(show top 50) (show all 654)
# Title Authors Year
1
Genomic Characterization of Listeria monocytogenes Isolates Associated with Clinical Listeriosis and the Food Production Environment in Ireland. ( 29558450 )
2018
2
The case of septical form of listeriosis with numerous abscesses of liver ( 29667380 )
2018
3
Listeriosis Outbreaks Associated with Soft Cheeses, United States, 1998-2014<sup>1</sup>. ( 29774843 )
2018
4
Increasing Incidence of Listeriosis and Infection-associated Clinical Outcomes. ( 29214753 )
2018
5
Awareness of Listeriosis and Methylmercury toxicity public health recommendations and diet during pregnancy. ( 29678412 )
2018
6
Invasive Listeriosis of Intracardiac Device. ( 29849653 )
2018
7
Septicemic listeriosis: An emerging food-borne illness in India? ( 29735848 )
2018
8
A Comparison of Oral and Intravenous Mouse Models of Listeriosis. ( 29361677 )
2018
9
Listeriosis in pregnancy: under-diagnosis despite over-treatment. ( 29022924 )
2018
10
Implicated Food Products for Listeriosis and Changes in Serovars of Listeria monocytogenes Affecting Humans in Recent Decades. ( 29958028 )
2018
11
Surveillance of listeriosis in the Tel Aviv District, Israel, 2010-2015. ( 29307320 )
2018
12
Neonatal Listeriosis and The Importance of Body Surface Cultures. ( 29589345 )
2018
13
Campylobacteriosis, Salmonellosis, Yersiniosis, and Listeriosis as Zoonotic Foodborne Diseases: A Review. ( 29701663 )
2018
14
Genomic and phenotypic diversity of Listeria monocytogenes clonal complexes associated with human listeriosis. ( 29500754 )
2018
15
Genetic characterization of Listeria monocytogenes from ruminant listeriosis from different geographical regions in the U.S. ( 29290393 )
2018
16
Clinical management of women with listeriosis risk during pregnancy: a review of national guidelines. ( 29237320 )
2018
17
An outbreak of listeriosis linked to turkey meat products in the Czech Republic, 2012-2016. ( 29909819 )
2018
18
Erratum: Increasing Incidence of Listeriosis and Infection associated Clinical Outcomes. ( 29401569 )
2018
19
Listeriosis during the period 2003-2016. ( 29739228 )
2018
20
Whole-Genome Sequences of Two Listeria monocytogenes Serovar 1/2a Strains Responsible for a Severe Listeriosis Outbreak in Central Italy. ( 29903806 )
2018
21
Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases. ( 29372499 )
2018
22
Neuroinvasive Listeriosis: Could Petechial Hemorrhages be a Diagnostic Clue? ( 29722741 )
2018
23
Draft Genome Sequences of 510<i>Listeria monocytogenes</i>Strains from Food Isolates and Human Listeriosis Cases from Northern Italy. ( 29348329 )
2018
24
Genomic Characterization Helps Dissecting an Outbreak of Listeriosis in Northern Italy. ( 28856063 )
2017
25
Burden of salmonellosis, campylobacteriosis and listeriosis: a time series analysis, Belgium, 2012 to 2020. ( 28935025 )
2017
26
Listeriosis in two twin pregnancies after in vitro fertilization with differential outcome and literature review. ( 29179588 )
2017
27
Epidemiology and Molecular Typing of Pregnancy-Associated Listeriosis Cases in Lombardy, Italy, over a 10-Year Period (2005-2014). ( 28408795 )
2017
28
Comparative diagnostic efficacy of recombinant LLO and PI-PLC-based ELISAs for detection of listeriosis in animals. ( 28411150 )
2017
29
Changing US Population Demographics: What Does This Mean for Listeriosis Incidence and Exposure? ( 28632414 )
2017
30
Human Listeriosis Presenting as Breast Abscess: Report of a Rare Case. ( 28289572 )
2017
31
Epidemiology and treatment of the commonest form of listeriosis: meningitis and bacteraemia. ( 28956537 )
2017
32
Spontaneous listeriosis in grey mouse lemurs (Microcebus murinus), but not in Goodman's mouse lemurs (Microcebus lehilahytsara) of the same colony. ( 28888657 )
2017
33
Cross-border outbreak of listeriosis caused by cold-smoked salmon, revealed by integrated surveillance and whole genome sequencing (WGS), Denmark and France, 2015 to 2017. ( 29258647 )
2017
34
Pregnancy-related listeriosis. ( 28398675 )
2017
35
Corrigendum for: Pregnancy-related Listeriosis. ( 28861948 )
2017
36
A clade of Listeria monocytogenes serotype 4b variant strains linked to recent listeriosis outbreaks associated with produce from a defined geographic region in the US. ( 28464038 )
2017
37
A nationwide outbreak of listeriosis associated with cold-cuts, Sweden 2013-2014. ( 28649304 )
2017
38
Hospital-acquired listeriosis linked to a persistently contaminated milkshake machine. ( 28065212 )
2017
39
Listeriosis during pregnancy. ( 28536811 )
2017
40
Invasive listeriosis in a patient with several episodes of antibiotic associated colitis presumably due to Clostridium difficile. ( 28365900 )
2017
41
Draft Genome Sequences of 25 Listeria monocytogenes Isolates Associated with Human Clinical Listeriosis in Ireland. ( 28495762 )
2017
42
Molecular Tracing to Find Source of Protracted Invasive Listeriosis Outbreak, Southern Germany, 2012-2016. ( 28930013 )
2017
43
Genome Sequences of Two Listeria monocytogenes Strains from Nectarines Associated with Listeriosis in 2014. ( 28729255 )
2017
44
GNP-GAPDH1-22 nanovaccines prevent neonatal listeriosis by blocking microglial apoptosis and bacterial dissemination. ( 28903312 )
2017
45
Listeria monocytogenes in Food-Processing Facilities, Food Contamination, and Human Listeriosis: The Brazilian Scenario. ( 28767285 )
2017
46
Draft Genome Sequences of Listeria monocytogenes Strains from Listeriosis Outbreaks Linked to Soft Cheese in Washington State. ( 28883140 )
2017
47
Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis. ( 28507070 )
2017
48
Estimating the real incidence of invasive listeriosis through an integrated surveillance model in use in Lombardy (Italy, 2006-2014). ( 28446259 )
2017
49
Molecular Typing and Epidemiology of Human Listeriosis Cases, Denmark, 2002-2012(1). ( 26982714 )
2016
50
Factors influencing the time between onset of illness and specimen collection in the diagnosis of non-pregnancy associated listeriosis in England and Wales. ( 27341796 )
2016

Variations for Listeriosis

Expression for Listeriosis

Search GEO for disease gene expression data for Listeriosis.

Pathways for Listeriosis

GO Terms for Listeriosis

Biological processes related to Listeriosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.71 IL10 IL6 TNF
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.69 IL10 IL6 TNF
3 response to organic substance GO:0010033 9.67 CDH1 IL10 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.65 IL6 MBL2 TNF
5 inflammatory response GO:0006954 9.55 IDO1 IL10 IL6 LXN TNF
6 response to glucocorticoid GO:0051384 9.54 IL10 IL6 TNF
7 positive regulation of chemokine production GO:0032722 9.52 IL6 TNF
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.46 IL10 TNF
9 negative regulation of lipid storage GO:0010888 9.43 IL6 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.43 AKIRIN2 IL6 TNF
11 endothelial cell apoptotic process GO:0072577 9.4 IL10 TNF
12 negative regulation of cytokine secretion involved in immune response GO:0002740 9.32 IL10 TNF
13 receptor biosynthetic process GO:0032800 8.96 IL10 TNF
14 negative regulation of growth of symbiont in host GO:0044130 8.8 IL10 MBL2 TNF

Sources for Listeriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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