MCID: LST001
MIFTS: 54

Listeriosis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Listeriosis

MalaCards integrated aliases for Listeriosis:

Name: Listeriosis 12 74 52 58 54 3 43 15 17 71 32
Listeria Infection 12 74 52 58 3
Infection by Listeria Monocytogenes 12
Listeria Monocytogenes Infection 52
Listeria Infections 42

Characteristics:

Orphanet epidemiological data:

58
listeriosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Worldwide),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11573
ICD9CM 34 027.0
MeSH 43 D008088
NCIt 49 C82994
SNOMED-CT 67 4241002
ICD10 32 A32 A32.9
MESH via Orphanet 44 D008088
ICD10 via Orphanet 33 A32.0 A32.1 A32.7 more
UMLS via Orphanet 72 C0023860
Orphanet 58 ORPHA533
UMLS 71 C0023860

Summaries for Listeriosis

NIH Rare Diseases : 52 A listeria infection or listeriosis is an infection caused by a bacteria known as Listeria monocytogenes . It mainly affects newborn infants, elderly patients, pregnant women and patients who have low immunity. Listeria can be spread by several methods. A common cause is ingestion (food-borne transmission) of unpasteurized milk or contaminated vegetables. It can also be transmitted from mother to fetus during pregnancy or directly to the newborn at the time of delivery. Listeriosis can cause a variety of symptoms, depending on the person and the part of the body affected. Pregnant women typically have only fever and other flu-like symptoms, such as fatigue and muscle aches. However, infections during pregnancy can lead to miscarriage, stillbirth, premature delivery, or life-threatening infection of the newborn, including generalized infection (sepsis) or inflammation of the membranes that cover the brain (meningitis ). Sometimes listeriosis involves many organs and presents with masses filled with pus (microabscesses or granulomas). Older children with Listeria infections frequently develop meningitis. Treatment include antibiotics such as ampicillin and aminoglycosides .

MalaCards based summary : Listeriosis, also known as listeria infection, is related to meningoencephalitis and meningitis, and has symptoms including vomiting, fever and back pain. An important gene associated with Listeriosis is ACTA1 (Actin Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ampicillin and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and liver, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Listeria monocytogenes, which is transmitted by ingestion of contaminated food or raw milk or transmitted by congenital method. Ingestion of Listeria by pregnant women has symptom nausea, has symptom vomiting, has symptom diarrhea, has symptom fever, has symptom malaise, has symptom back pain, and has symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

MedlinePlus : 42 Listeriosis is a foodborne illness caused by Listeria monocytogenes, bacteria found in soil and water. It can be in a variety of raw foods as well as in processed foods and foods made from unpasteurized milk. Listeria is unlike many other germs because it can grow even in the cold temperature of the refrigerator. Symptoms include fever and chills, headache, upset stomach and vomiting. Treatment is with antibiotics. Anyone can get the illness. But it is most likely to affect pregnant women and unborn babies, older adults, and people with weak immune systems. To reduce your risk Use precooked and ready-to-eat foods as soon as you can Avoid raw milk and raw milk products Heat ready-to-eat foods and leftovers until they are steaming hot Wash fresh fruits and vegetables Avoid rare meat and refrigerated smoked seafood Centers for Disease Control and Prevention

CDC : 3 Listeriosis is a serious infection usually caused by eating food contaminated with the bacterium Listeria monocytogenes. An estimated 1,600 people get listeriosis each year, and about 260 die. The infection is most likely to sicken pregnant women and their newborns, adults aged 65 or older, and people with weakened immune systems.

Wikipedia : 74 Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although L.... more...

Related Diseases for Listeriosis

Diseases related to Listeriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 552)
# Related Disease Score Top Affiliating Genes
1 meningoencephalitis 31.4 TNF IL10 CD8A CD4 CCR6
2 meningitis 31.2 TNF TLR2 MBL2 IL10
3 toxoplasmosis 31.1 TNF TLR2 ITGAM IL10 IDO1
4 listeria meningitis 31.0 TNF NDUFA9 CD8A
5 mastitis 30.9 TLR2 H2AC18 CCR6
6 prosthetic joint infection 30.9 TLR2 MBL2
7 pharyngitis 30.8 TNF CD8A CD4
8 bacterial meningitis 30.8 TNF TLR2 MBL2 IL10
9 q fever 30.7 TNF TLR2 MBL2 IL10
10 peritonitis 30.7 TNF TLR2 ITGAM IL10
11 pfeiffer syndrome 30.7 H2AC18 CD8A CD4 CCR6
12 salmonellosis 30.7 TNF TLR2 IL10 CD8A CD4 CCR6
13 syphilis 30.7 CD8A CD4 CCR6
14 congenital toxoplasmosis 30.7 IL10 CD8A CD4
15 candidiasis 30.6 TNF TLR2 MBL2 IL10
16 plague 30.6 TNF TLR2 IL10 CD8A CD4
17 echinococcosis 30.6 TNF TLR2 IL10 CD8A
18 respiratory failure 30.6 TNF IL10 H2AC18 CD4 ACTA1
19 lymphadenitis 30.6 TNF IL10 ICOSLG CD4 CCR6
20 tularemia 30.5 TNF TLR2 MBL2 CD8A CD4
21 stomatitis 30.5 TNF TLR2 IL10 CD4
22 bronchiolitis 30.5 TNF TLR2 IL10
23 severe combined immunodeficiency 30.5 IL10 ICOSLG H2AC18 CD4 CCR6
24 orchitis 30.5 TNF IL10 H2AC18 CD8A CD4
25 nervous system disease 30.5 TNF ICOSLG H2AC18 CD4 CCR6
26 t cell deficiency 30.5 CD8A CD4 CCR6
27 choroiditis 30.5 TNF IL10 CD4
28 oral candidiasis 30.5 CD8A CD4 CCR6
29 mast cell neoplasm 30.5 PRF1 ICOSLG H2AC18 CD8A CD4
30 acquired immunodeficiency syndrome 30.5 TNF ITGAM IL10 CD4 CCR6
31 colitis 30.4 TNF TLR2 IL10 ICOSLG CCR6
32 vaginitis 30.4 TNF TLR2 IL10 CD4 CCR6
33 endocarditis 30.4 TNF TLR2 IL10
34 central nervous system disease 30.4 TNF ICOSLG H2AC18 CD4 CCR6
35 leishmaniasis 30.4 TNF TLR2 MBL2 ITGAM IL10
36 pyelonephritis 30.4 TNF MBL2 IL10
37 amebiasis 30.4 TNF TLR2 CD4
38 exanthem 30.4 TNF IL10 ICOSLG H2AC18 CD8A CD4
39 myelitis 30.4 TNF IL10 ICOSLG CCR6
40 combined t cell and b cell immunodeficiency 30.3 IL10 ICOSLG H2AC18 CD8A CD4 CCR6
41 immune deficiency disease 30.3 TNF MBL2 IL10 IDO1 ICOSLG H2AC18
42 leptospirosis 30.3 TNF TLR2 IL10
43 thrombocytopenia 30.3 TNF TLR2 PRF1 ITGAM IL10
44 tonsillitis 30.3 TNF TLR2 IL10
45 bacteriuria 30.3 TLR2 PRF1 H2AC18
46 otitis media 30.2 TNF TLR2 MBL2 IL10
47 visceral leishmaniasis 30.2 TNF TLR2 IL10
48 mouth disease 30.2 IL10 ICOSLG H2AC18 CCR6
49 ileitis 30.2 TNF TLR2 IL10 CCR6
50 endophthalmitis 30.2 TNF TLR2 PRF1 CD4

Comorbidity relations with Listeriosis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Listeriosis:



Diseases related to Listeriosis

Symptoms & Phenotypes for Listeriosis

Symptoms:

12
  • vomiting
  • fever
  • back pain
  • headache
  • diarrhea
  • nausea
  • malaise

UMLS symptoms related to Listeriosis:


fever, pruritus

MGI Mouse Phenotypes related to Listeriosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 BAHD1 CCR6 CD4 CD8A IDO1 IL10
2 immune system MP:0005387 9.4 BAHD1 CCR6 CD4 CD8A IDO1 IL10

Drugs & Therapeutics for Listeriosis

Drugs for Listeriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ampicillin Approved, Vet_approved 69-53-4 6249
2
Amoxicillin Approved, Vet_approved 26787-78-0 33613
3 Anti-Bacterial Agents
4 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Successful Treatment of Maternal Listeria Monocytogenes Bacteremia in the First Trimester of Pregnancy: a Case Report and Review of Literatures Completed NCT03248973 Ampicillin Injection
2 Incidence, Risk Factors and Impact on Renal Function of the Appearance of Crystalluria Under High-dose Intravenous Amoxicillin Completed NCT02853292
3 Multicentric Observational National Analysis of Listeriosis and Listeria : Evaluation of the Neurological Consequences of Perinatal Listeriosis Infection Recruiting NCT02580812
4 Multicentric Observational NAtional Study on LISteriosis and ListeriA Recruiting NCT01520597
5 Genetic Susceptibility to Listeriosis - Listeria-GEN Recruiting NCT03357536
6 Genetic Susceptibility and Biomarkers in Listeriosis (MONALISA-GENBIO) Enrolling by invitation NCT02924220

Search NIH Clinical Center for Listeriosis

Cochrane evidence based reviews: listeriosis

Genetic Tests for Listeriosis

Anatomical Context for Listeriosis

MalaCards organs/tissues related to Listeriosis:

40
T Cells, Brain, Liver, Bone, Testes, Neutrophil, Skin

Publications for Listeriosis

Articles related to Listeriosis:

(show top 50) (show all 4015)
# Title Authors PMID Year
1
Evidence of hypervirulence in Listeria monocytogenes clonal complex 14. 61 42
31524579 2019
2
Characterization of Listeria monocytogenes serovar 1/2a, 1/2b, 1/2c and 4b by high resolution melting analysis for epidemiological investigations. 42
31487606 2019
3
N-Glycosylation Plays an Essential and Species-Specific Role in Anti-Infection Function of Milk Proteins Using Listeria monocytogenes as Model Pathogen. 42
31479258 2019
4
Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. 54 61
17111046 2006
5
Indoleamine 2,3-dioxygenase is regulated by IFN-gamma in the mouse placenta during Listeria monocytogenes infection. 54 61
12517946 2003
6
Listeriolysin and IrpA are major protein targets of the human humoral response against Listeria monocytogenes. 54 61
9284184 1997
7
Development of a multiplex real-time PCR to differentiate the four major Listeria monocytogenes serotypes in isolates from meat processing plants. 61
31948615 2020
8
Risk-based assessment and criteria specification of the microbial safety of wastewater reuse in food processing: Managing Listeria monocytogenes contamination in pasteurized fluid milk. 61
31927094 2020
9
Septicemic listeriosis during adalimumab- and golimumab-based treatment for ulcerative colitis: case presentation and literature review. 61
31222454 2020
10
Listeria monocytogenes septicemia and meningoencephalitis associated with relapsed and refractory follicular lymphoma. 61
32033853 2020
11
Effect of subinhibitory concentrations of ampicillin on Listeria monocytogenes. 61
31027868 2020
12
Epidemiology of Human Listeriosis in China During 2008-2017. 61
31556722 2020
13
Experimental listeriosis: A study of purinergic and cholinergic inflammatory pathway. 61
31882365 2020
14
Susceptibility of aging mice to listeriosis: Role of anti-inflammatory responses with enhanced Treg-cell expression of CD39/CD73 and Th-17 cells. 61
31974050 2020
15
Cutaneous listeriosis, a case series of 16 consecutive patients over 25 years. 61
31629016 2020
16
Bacteriocins of Listeria monocytogenes and Their Potential as a Virulence Factor. 61
32033406 2020
17
Public health impact of foodborne exposure to naturally occurring virulence-attenuated Listeria monocytogenes: inference from mouse and mathematical models. 61
31897288 2020
18
Causes of fever in pregnant women with acute undifferentiated fever: a prospective multicentric study. 61
31955353 2020
19
The potential role of interleukin-37 in infectious diseases. 61
31633447 2020
20
A Real-Time PCR Screening Assay for Rapid Detection of Listeria Monocytogenes Outbreak Strains. 61
31936251 2020
21
Listeriosis Outbreak in South Africa: A Comparative Analysis with Previously Reported Cases Worldwide. 61
31963542 2020
22
Outcomes of neonates with listeriosis supported with extracorporeal membrane oxygenation from 1991 to 2017. 61
31636340 2020
23
Retrospective investigation of listeriosis outbreaks in small ruminants using different analytical approaches for whole genome sequencing-based typing of Listeria monocytogenes. 61
31629888 2020
24
Short communication: Long-term -20°C survival of Listeria monocytogenes in artificially and process-contaminated ice cream involved in an outbreak of listeriosis. 61
31704018 2020
25
The epidemiology of listeriosis in pregnant women and children in New Zealand from 1997 to 2016: an observational study. 61
31992263 2020
26
Changes in cardiac and hepatic energetic metabolism in gerbils infected by Listeria monocytogenes. 61
31604154 2020
27
Prevalence and antimicrobial resistance of Listeria species, and virulence genes, serotyping, PCR-RFLP and PFGE typing of Listeria monocytogenes isolated from retail ready-to-eat foods. 61
31926017 2020
28
Short communication: Multistate outbreak of Listeria monocytogenes infections retrospectively linked to unpasteurized milk using whole-genome sequencing. 61
31733864 2020
29
Growth Behavior of Listeria monocytogenes in a Traditional Norwegian Fermented Fish Product (Rakfisk), and Its Inhibition through Bacteriophage Addition. 61
31979202 2020
30
A high-throughput microbial growth data assembly and analysis protocol to elucidate the strain-specific NaCl tolerance variation in Listeria monocytogenes. 61
31900307 2020
31
The prevalence of Listeria monocytogenes in meat products in China: A systematic literature review and novel meta-analysis approach. 61
31655356 2020
32
Post-process treatments are effective strategies to reduce Listeria monocytogenes on the surface of leafy greens: A pilot study. 61
31678818 2020
33
Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation. 61
31619761 2020
34
Vaccine strain Listeria monocytogenes abscess in a dog: a case report. 61
31864375 2019
35
Mutation of the Transcriptional Regulator YtoI Rescues Listeria monocytogenes Mutants Deficient in the Essential Shared Metabolite 1,4-Dihydroxy-2-Naphthoate (DHNA). 61
31685546 2019
36
Genetic diversity of Listeria monocytogenes strains in ruminant abortion and rhombencephalitis cases in comparison with the natural environment. 61
31849320 2019
37
Trained immunity confers broad-spectrum protection against bacterial infections. 61
31889191 2019
38
Sentinel Listeriosis Surveillance in Selected Hospitals, China, 2013-2017. 61
31742514 2019
39
An Assessment of Listeriosis Risk Associated with a Contaminated Production Lot of Frozen Vegetables Consumed under Alternative Consumer Handling Scenarios. 61
31742442 2019
40
Antibiotic treatment for invasive nonpregnancy-associated listeriosis and mortality: a retrospective cohort study. 61
31399915 2019
41
Comparative whole cell proteomics of Listeria monocytogenes at different growth temperatures. 61
31838794 2019
42
A systematic review and meta-analysis on the prevalence of antibiotic-resistant Listeria species in food, animal and human specimens in Iran. 61
31749464 2019
43
Genomic Diversity of Common Sequence Types of Listeria monocytogenes Isolated from Ready-to-Eat Products of Animal Origin in South Africa. 61
31817243 2019
44
Genomic dissection of the most prevalent Listeria monocytogenes clone, sequence type ST87, in China. 61
31870294 2019
45
Bio-Plex suspension array immuno-detection of Listeria monocytogenes from cantaloupe and packaged salad using virulence protein inducing activated charcoal enrichment media. 61
31421770 2019
46
Characterization of the pathogenesis and immune response to Listeria monocytogenes strains isolated from a sustained national outbreak. 61
31862952 2019
47
An outbreak of multiple genotypes of Listeria monocytogenes in New Zealand linked to contaminated ready-to-eat meats-a retrospective analysis using whole-genome sequencing. 61
31562639 2019
48
Occurrence and antibiogram of Listeria monocytogenes Isolates from Retail Meat Shops at Erbil City, Kurdistan Region, Iraq. 61
31897400 2019
49
Predictive Model of Listeria monocytogenes Growth in Queso Fresco. 61
31714806 2019
50
Listeriolysin S may inhibit the anti-listerial properties of Lactobacillus plantarum. 61
31521800 2019

Variations for Listeriosis

Expression for Listeriosis

Search GEO for disease gene expression data for Listeriosis.

Pathways for Listeriosis

Pathways related to Listeriosis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TLR2 MBL2 KLRG1 ITGAX ITGAM
2
Show member pathways
13.3 TNF TLR2 ITGAX ITGAM IL10 CD4
3
Show member pathways
12.7 TNF PRF1 IL10 ICOSLG CD8A CD4
4
Show member pathways
12.57 TNF PRF1 ITGAX ITGAM ACTA1
5
Show member pathways
12.5 TNF TLR2 IL10 CD8A CD4
6 12.44 TNF TLR2 IL10 IDO1 CD8A
7
Show member pathways
12.18 TNF TLR2 ITGAM IL10
8 12 ITGAM ICOSLG CD8A CD4
9 11.97 TNF TLR2 ITGAX ITGAM IL10
10
Show member pathways
11.91 TNF TLR2 IL10 CD4
11 11.81 TNF ITGAX ITGAM IL10
12 11.72 TLR2 ITGAX ITGAM
13 11.71 TNF TLR2 ITGAM IL10
14 11.7 TNF ITGAX ITGAM IL10 CD8A CD4
15 11.67 TNF ITGAM IL10
16 11.66 TNF ITGAM CD8A CD4
17
Show member pathways
11.57 TNF PRF1 CD8A
18 11.52 TNF TLR2 ITGAM
19 11.52 ITGAX ITGAM ACTA1
20 11.44 TNF TLR2 IL10
21 11.34 TNF ITGAM IL10 CD8A CD4 CCR6
22 11.25 TNF IL10 IDO1
23 11.24 TNF TLR2 ITGAM ACTA1
24 11.07 TNF IL10 CD4
25 10.97 TNF ITGAX ITGAM IL10 CD8A CD4

GO Terms for Listeriosis

Cellular components related to Listeriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.5 TNF TLR2 MBL2 ITGAX ITGAM CD4
2 membrane raft GO:0045121 9.46 TNF TLR2 ITGAM CD4
3 external side of plasma membrane GO:0009897 9.17 TNF ITGAX ITGAM ICOSLG CD8A CD4

Biological processes related to Listeriosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.77 TNF ITGAX ITGAM IL10 CD4
2 immune response GO:0006955 9.73 TNF TLR2 IL10 CD8A CD4 CCR6
3 cellular defense response GO:0006968 9.61 PRF1 KLRG1 CCR6
4 T cell activation GO:0042110 9.58 ICOSLG CD8A CD4
5 immune system process GO:0002376 9.5 TLR2 MBL2 ITGAM IDO1 ICOSLG CD8A
6 response to molecule of bacterial origin GO:0002237 9.49 TLR2 IL10
7 endothelial cell apoptotic process GO:0072577 9.48 TNF IL10
8 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 TNF IL10
9 microglial cell activation GO:0001774 9.33 TNF TLR2 ITGAM
10 receptor biosynthetic process GO:0032800 9.32 TNF IL10
11 inflammatory response GO:0006954 9.1 TNF TLR2 LXN KLRG1 IL10 IDO1

Molecular functions related to Listeriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.02 TLR2 KLRG1 ITGAX CD4 CCR6

Sources for Listeriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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