MCID: LTT006
MIFTS: 19

Littoral Cell Angioma of the Spleen

Categories: Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Littoral Cell Angioma of the Spleen

MalaCards integrated aliases for Littoral Cell Angioma of the Spleen:

Name: Littoral Cell Angioma of the Spleen 52 71
Littoral Cell Angioma 52

Classifications:



External Ids:

UMLS 71 C1627365

Summaries for Littoral Cell Angioma of the Spleen

NIH Rare Diseases : 52 Littoral cell angioma of the spleen (LCA) is a very rare, vascular tumor of the spleen . Most reported cases have been non-cancerous (benign), but an LCA can become cancerous (malignant). In many cases, LCA does not cause any symptoms. It may be discovered due to abdominal pain or by accident (incidentally) when having a physical exam or during tests performed for other reasons. Besides abdominal pain, LCA may cause an enlarged spleen (splenomegaly), anemia , or thrombocytopenia . Case reports have associated LCA with various other conditions including portal hypertension , Crohn's disease , Gaucher disease , lymphoma, aplastic anemia , colon cancer , pancreatic cancer, lung cancer, and myelodysplastic syndrome . LCA affects men and women equally and can occur at any age, but it mostly occurs in middle-aged adults and occasionally in children. LCA is difficult to diagnose with imaging studies because of its similar appearance to other types of benign splenic tumors as well as malignant tumors such as lymphoma and Kaposi sarcoma . For this reason, the specific tumor type often cannot be confirmed until it is biopsied or removed, and then tested. Currently, the main treatment for LCA is open splenectomy (spleen removal) or hand-assisted laparoscopic total splenectomy, a less-invasive technique. Some authors have suggested only continued surveillance of the tumor may be appropriate if no symptoms are present, because the chance for malignancy in an asymptomatic person is thought to be low, and splenectomy leads to impairment of immune function.

MalaCards based summary : Littoral Cell Angioma of the Spleen, also known as littoral cell angioma, is related to splenomegaly and hypersplenism. Affiliated tissues include spleen, colon and testes.

Wikipedia : 74 Littoral cell angioma, abbreviated LCA, and formally known as littoral cell angioma of the spleen, is a... more...

Related Diseases for Littoral Cell Angioma of the Spleen

Diseases related to Littoral Cell Angioma of the Spleen via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 splenomegaly 10.7
2 hypersplenism 10.5
3 hemangioma 10.5
4 rare vascular tumor 10.5
5 hepatocellular carcinoma 10.4
6 angiosarcoma 10.4
7 thrombocytopenia 10.3
8 vascular cancer 10.3
9 pancreatic adenocarcinoma 10.3
10 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.3
11 cavernous hemangioma 10.3
12 colorectal cancer 10.2
13 sarcoidosis 1 10.2
14 gaucher disease, type i 10.2
15 meningioma, radiation-induced 10.2
16 meningioma, familial 10.2
17 myelodysplastic syndrome 10.2
18 deficiency anemia 10.2
19 colorectal adenocarcinoma 10.2
20 lymphoma 10.2
21 portal hypertension 10.2
22 spinal meningioma 10.2
23 iron deficiency anemia 10.2
24 pancytopenia 10.2
25 pulmonary sarcoidosis 10.2
26 gaucher's disease 10.2
27 hepatitis b 10.2
28 iron metabolism disease 10.2
29 hemangioma of spleen 10.2
30 secretory meningioma 10.2
31 lymphoplasmacyte-rich meningioma 10.2
32 adenoma 10.2
33 b-cell lymphoma 10.2
34 polycythemia 10.2
35 neuropathy 10.2
36 ovarian epithelial cancer 10.2
37 rare tumor 10.2
38 thyroid cancer, nonmedullary, 1 10.1
39 wilms tumor 1 10.1
40 ascites, chylous 10.1
41 wilms tumor 5 10.1
42 alpha-thalassemia 10.1
43 marginal zone b-cell lymphoma 10.1
44 splenic marginal zone lymphoma 10.1
45 clostridium difficile colitis 10.1
46 bacillary angiomatosis 10.1
47 lymphoproliferative syndrome 10.1
48 thalassemia 10.1
49 disseminated intravascular coagulation 10.1
50 splenic sequestration 10.1

Graphical network of the top 20 diseases related to Littoral Cell Angioma of the Spleen:



Diseases related to Littoral Cell Angioma of the Spleen

Symptoms & Phenotypes for Littoral Cell Angioma of the Spleen

Drugs & Therapeutics for Littoral Cell Angioma of the Spleen

Search Clinical Trials , NIH Clinical Center for Littoral Cell Angioma of the Spleen

Genetic Tests for Littoral Cell Angioma of the Spleen

Anatomical Context for Littoral Cell Angioma of the Spleen

MalaCards organs/tissues related to Littoral Cell Angioma of the Spleen:

40
Spleen, Colon, Testes, Lung, Liver, Thyroid, Monocytes

Publications for Littoral Cell Angioma of the Spleen

Articles related to Littoral Cell Angioma of the Spleen:

(show top 50) (show all 153)
# Title Authors PMID Year
1
Massive splenomegaly correlates with malignancy: 180 cases of splenic littoral cell tumors in the world literature. 52 61
24987971 2014
2
Littoral cell angioma of the spleen. 61 52
23417366 2013
3
Practical Applications in Immunohistochemistry: An Immunophenotypic Approach to the Spleen. 61
30917045 2019
4
Sclerosing angiomatoid nodular transformation (SANT) of the spleen: A case report on CT and MRI. 61
31501694 2019
5
Littoral cell angioma of spleen. 61
29024432 2019
6
Laparoscopic splenectomy for littoral cell angioma of the spleen: A case report. 61
30882665 2019
7
The Sequence of the Evil: A Case Report of Idiopathic Noncirrhotic Portal Hypertension Associated With Littoral Cell Angioma of the Spleen, 4 Years After the Successful Treatment of a Colon Cancer. 61
31024210 2019
8
Huge Littoral Cell Angioma of the Spleen: A Case Report. 61
31292330 2019
9
Littoral Cell Angioma: A Rare Cause of Pediatric Thrombocytopenia. 61
30050266 2018
10
Successful chemotherapeutic treatment for metastatic littoral cell angioma: A case report. 61
29642193 2018
11
A Novel Presentation of Littoral Cell Angioma and Lymphatic Malformations in a Neonate. 61
29610184 2018
12
[13 cases of littoral cell angioma in spleens]. 61
28628153 2017
13
Littoral-cell angioma of the spleen: a case report. 61
28607812 2017
14
Littoral cell angioma of the spleen: Cytological findings and review of the literature. 61
28469325 2017
15
Incidental littoral cell angioma in refractory immune thrombocytopenic purpura. 61
28302694 2017
16
Case report of a littoral cell angioma of the spleen and accessory spleens: A benign vascular tumour. 61
28965086 2017
17
Myoid Angioendothelioma of the Spleen: A Rare Case Report and Literature Review. 61
28293056 2017
18
Incidentally Diagnosed Multiple Vascular Lesions of the Spleen: Littoral Cell Angioma or Hemangioma? 61
27900277 2016
19
Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies. 61
27374010 2016
20
Laparoscopic splenectomy for a littoral cell angioma of the spleen: Case report. 61
26601099 2015
21
Persistent thrombocytopaenia in a young man with splenomegaly, rebound thrombocytosis after splenectomy and subsequent pulmonary embolism: splenic littoral cell angioma and associated events. 61
26604237 2015
22
Littoral cell angioma: A case report. 61
26488026 2015
23
Incidental splenic littoral cell angioma complicating a case of Rolon cancer: A case report. 61
26499824 2015
24
Laparoscopic splenectomy for splenic littoral cell angioma. 61
26074704 2015
25
Distinctive immunohistochemical staining in littoral cell angioma using ERG and WT-1. 61
25792460 2015
26
Unicentric mesenteric Castleman's disease with littoral cell angioma, anemia, growth retardation and amenorrhea: A case report. 61
25789041 2015
27
[Littoral cell angioma. An uncommon cause of constitutional syndrome]. 61
25070519 2015
28
Littoral cell angioma in the spleen. 61
25585188 2015
29
Littoral cell angioma in a patient with Crohn's disease. 61
25705528 2015
30
Littoral cell angioma of the spleen: report of three cases and literature review. 61
26339427 2015
31
Paraneoplastic disseminated intravascular coagulation caused by splenic littoral cell angioma. 61
24789322 2014
32
A rare case of splenic littoral cell angioma in a child. 61
25328338 2014
33
Splenic littoral cell hemangioendothelioma: report of a case with hepatic metastases and review of the literature. 61
24420309 2014
34
Multimodality imaging of splenic lesions and the role of non-vascular, image-guided intervention. 61
24525666 2014
35
Littoral cell angioma: gastrointestinal associations. 61
24799975 2014
36
Low-grade, metastasizing splenic littoral cell angiosarcoma presenting with hepatic cirrhosis and splenic artery aneurysm. 61
23426963 2013
37
Littoral cell angioma: review of the literature and case report. 61
25073259 2013
38
Littoral cell angioma of the spleen: sonographic-pathologic comparison. 61
23525396 2013
39
Littoral-cell angioma of the spleen. 61
23432174 2013
40
Littoral cell angioma of the spleen--a surprising cause of anemia. 61
24322045 2013
41
Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population? 61
23042283 2012
42
Extramedullary hemopoiesis and littoral cell angioma of the spleen: our experience and review. 61
22819901 2012
43
Rapidly progressive B-cell dominated inflammatory neuropathy and littoral cell angioma of the spleen associated with plasmablastic B-cell lymphoma. 61
22098375 2012
44
Littoral cell angioma and angiosarcoma of the spleen: report of two cases in siblings and review of the literature. 61
22068970 2012
45
[Splenomegaly with multiple unclear parenchymal lesions. Splenomegaly]. 61
22290454 2012
46
Littoral cell angioma of spleen in a patient with obstructive jaundice. 61
22499316 2012
47
Multifocal capillary hemangioma (hemangiomatosis) of the spleen. 61
22495727 2012
48
Littoral cell angioma: diagnosis by image-guided biopsy. 61
23090739 2012
49
Littoral cell angioma mimicking hepatic tumor. 61
23986846 2012
50
Littoral cell angioma of spleen: an uncommon presentation of a rare neoplasm. 61
23393626 2012

Variations for Littoral Cell Angioma of the Spleen

Expression for Littoral Cell Angioma of the Spleen

Search GEO for disease gene expression data for Littoral Cell Angioma of the Spleen.

Pathways for Littoral Cell Angioma of the Spleen

GO Terms for Littoral Cell Angioma of the Spleen

Sources for Littoral Cell Angioma of the Spleen

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