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MCID: LVD003
MIFTS: 37

Livedoid Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Livedoid Vasculitis

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MalaCards integrated aliases for Livedoid Vasculitis:

Name: Livedoid Vasculitis 12 52 15 32
Livedoid Vasculopathy 12 52 58
Livedo Reticularis with Summer Ulcerations 52 58
Livedo Reticularis with Winter Ulcerations 52
Segmental Hyalinizing Vasculopathy 52
Segmental Hyalinizing Vasculitis 58
Milian Atrophie Blanche 58
Livedo Vasculitis 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare circulatory system diseases
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:0040099
ICD9CM 34 709.1
ICD10 32 L95.0
Orphanet 58 ORPHA542643
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Summaries for Livedoid Vasculitis

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NIH Rare Diseases : 52 Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche ) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

MalaCards based summary : Livedoid Vasculitis, also known as livedoid vasculopathy, is related to purpura and sticky platelet syndrome. An important gene associated with Livedoid Vasculitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. Affiliated tissues include skin, heart and liver, and related phenotype is Increased replication of vaccinia virus (VACV).

Disease Ontology : 12 A vasculitis with purpuric ulcers.

Wikipedia : 74 Livedoid vasculopathy is a chronic cutaneous disease seen predominantly in young to middle-aged women.... more...

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Related Diseases for Livedoid Vasculitis

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Diseases related to Livedoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 purpura 30.6 SERPINC1 F2 CD40LG
2 sticky platelet syndrome 30.5 SERPINE1 SERPINC1
3 protein c deficiency 29.8 SERPINE1 SERPINC1 MTHFR F2
4 chronic venous insufficiency 29.8 SERPINE1 MTHFR F2
5 venous insufficiency 29.8 SERPINE1 MTHFR F2
6 thrombophilia due to thrombin defect 29.7 SERPINE1 SERPINC1 MTHFR F2
7 sneddon syndrome 29.5 SERPINC1 F2 ADA2
8 branch retinal artery occlusion 29.5 SERPINC1 PLG MTHFR F2
9 thrombocytopenia 29.5 SERPINE1 SERPINC1 F2 CD40LG
10 protein s deficiency 29.4 SERPINE1 SERPINC1 MTHFR F2
11 antithrombin iii deficiency 29.4 SERPINC1 PLG MTHFR F2
12 homocysteinemia 29.4 SERPINE1 SERPINC1 MTHFR F2
13 intracranial thrombosis 29.3 SERPINC1 PLG MTHFR F2
14 disseminated intravascular coagulation 29.2 SERPINF2 SERPINE1 SERPINC1 PLG F2
15 antiphospholipid syndrome 29.2 SERPINE1 SERPINC1 MTHFR F2 CD40LG
16 central retinal artery occlusion 29.0 SERPINC1 PLG LPA F2 CD40LG
17 retinal artery occlusion 29.0 SERPINE1 SERPINC1 PLG MTHFR F2
18 thrombophilia due to activated protein c resistance 28.8 SERPINF2 SERPINE1 SERPINC1 PLG MTHFR F2
19 thrombophilia 28.6 SERPINF2 SERPINE1 SERPINC1 PLG MTHFR F2
20 thrombosis 28.0 SERPINF2 SERPINE1 SERPINC1 PLG MTHFR F2
21 stroke, ischemic 27.8 SERPINF2 SERPINE1 SERPINC1 PLG MTHFR LPA
22 vasculitis 10.8
23 skin disease 10.5
24 dowling-degos disease 1 10.4
25 muscular dystrophy white matter spongiosis 10.4
26 polyarteritis nodosa 10.4
27 platelet aggregation, spontaneous 10.4 SERPINF2 SERPINC1
28 cold urticaria 10.3 SERPINF2 SERPINC1
29 blue toe syndrome 10.3 SERPINC1 F2
30 waterhouse-friderichsen syndrome 10.3 SERPINC1 F2
31 hepatic infarction 10.3 SERPINC1 F2
32 giant hemangioma 10.3 SERPINC1 F2
33 cavernous sinus thrombosis 10.3 SERPINC1 F2
34 telangiectasis 10.3
35 prothrombin deficiency, congenital 10.3 SERPINC1 F2
36 prothrombin deficiency 10.3 SERPINC1 F2
37 collagen disease 10.3
38 hepatic coma 10.3 SERPINC1 F2
39 fibrinolytic defect 10.3 SERPINE1 SERPINC1
40 leech infestation 10.3 SERPINC1 PLG
41 cardiac tuberculosis 10.3 SERPINE1 SERPINC1
42 vitamin k deficiency bleeding 10.3 SERPINC1 F2
43 esophageal varix 10.3 SERPINC1 F2
44 peripheral vertigo 10.3 SERPINC1 F2
45 kidney cortex necrosis 10.3 PLG F2
46 plasminogen activator inhibitor-1 deficiency 10.2 SERPINF2 SERPINE1
47 encephalopathy, familial, with neuroserpin inclusion bodies 10.2 SERPINC1 PLG
48 meningococcemia 10.2 SERPINE1 SERPINC1
49 hemopericardium 10.2 PLG F2
50 dysfibrinogenemia, congenital 10.2 SERPINC1 F2

Graphical network of the top 20 diseases related to Livedoid Vasculitis:



Diseases related to Livedoid Vasculitis
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Symptoms & Phenotypes for Livedoid Vasculitis

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GenomeRNAi Phenotypes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased replication of vaccinia virus (VACV) GR00362-A 8.92 LPA SERPINC1 SERPINE1 SERPINF2
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Drugs & Therapeutics for Livedoid Vasculitis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Correlation of Genetic Polymorphism and Livedo Vasculitis Completed NCT00975871

Search NIH Clinical Center for Livedoid Vasculitis

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Genetic Tests for Livedoid Vasculitis

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Anatomical Context for Livedoid Vasculitis

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MalaCards organs/tissues related to Livedoid Vasculitis:

40
Skin, Heart, Liver, T Cells, Endothelial, Cortex, Spinal Cord
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Publications for Livedoid Vasculitis

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Articles related to Livedoid Vasculitis:

(show top 50) (show all 219)
# Title Authors PMID Year
1
Chronic leg ulcerations associated with livedoid vasculopathy successfully treated with rivaroxaban. 61
30767258 2020
2
Intravenous immunoglobulin in resistant livedoid vasculopathy: Analysis of a case series. 61
31965687 2020
3
Livedoid vasculopathy in Koreans: clinical features and response to rivaroxaban treatment. 61
31793049 2019
4
ADA2 Deficiency: Case Series of Five Patients with Varying Phenotypes. 61
31848804 2019
5
Vasculitic mononeuritis multiplex associated with livedoid vasculopathy. 61
31771777 2019
6
Livedoid vasculopathy presenting with leg ulcers. 61
31220328 2019
7
Livedoid vasculopathy: how to diagnose and how to treat? 61
31468610 2019
8
Characteristics, risk factors and treatment reality in livedoid vasculopathy - a multicentre analysis. 61
31009111 2019
9
Is there a role for hyperbaric oxygen therapy in the treatment of refractory wounds of rare etiology? 61
31523797 2019
10
Topical becaplermin gel is an effective adjuvant for long-standing ulcers of livedoid vasculopathy recalcitrant to anticoagulant therapy. 61
30706539 2019
11
Retiform non-blanchable purpuric plaques in a patient with systemic lupus erythematosus. 61
31126212 2019
12
Livedoid vasculopathy: does hyperhomocysteinaemia play an aetiological role? 61
31389788 2019
13
Prevention of recurrent ulceration of livedoid vasculopathy with long-term apixaban monotherapy. 61
30156315 2019
14
Endovenous Laser Ablation Treatment for Lower Extremity Ulcers Associated With Livedoid Vasculopathy. 61
30882502 2019
15
Atypical Mycobacterial Infection Arising Amid Corticosteroid Therapy for Livedoid Vasculopathy. 61
31687220 2019
16
Systemic lupus erythematosus with refractory ulcerated livedoid vasculopathy: Successful treatment with intravenous immunoglobulin and warfarin. 61
30455888 2018
17
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options. 61
29738044 2018
18
Traditional Korean medicine treatment for livedoid vasculopathy: Five case reports. 61
30100128 2018
19
Dermoscopy of early non-ulcerated livedoid vasculopathy. 61
30244265 2018
20
Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease. 61
29533274 2018
21
Livedoid vasculopathy: a compelling diagnosis. 61
30101138 2018
22
Systemic therapies for leg ulcers. 61
29989361 2018
23
The management of livedoid vasculopathy focused on direct oral anticoagulants (DOACs): four case reports successfully treated with rivaroxaban. 61
29663354 2018
24
Three cases of lymphocytic thrombophilic arteritis presenting with an annular eruption. 61
28752544 2018
25
Treatment of Livedoid Vasculopathy With Rivaroxaban: A Potential Use of New Oral Anticoagulants for Dermatologists. 61
29074145 2018
26
Livedoid vasculopathy in a patient with bullous pemphigoid and primary Sjögren's syndrome. 61
29526676 2018
27
Ulcerative livedoid vasculopathy responding to clopidogrel. 61
29892667 2018
28
Treatment for Livedoid Vasculopathy: A Systematic Review. 61
29141075 2018
29
Systemic Lupus Erythematosus Presenting as Livedoid Vasculopathy over the Forearms. 61
29911533 2018
30
Vasculopathies, cutaneous necrosis and emergency in dermatology. 61
28845953 2017
31
Prevention of livedoid vasculopathy recurrence by prolonged administration of rivaroxaban. 61
28609556 2017
32
Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy. 61
28901563 2017
33
Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis. 61
28252815 2017
34
Livedoid Vasculopathy. 61
28511282 2017
35
Occlusive Nonvasculitic Vasculopathy. 61
27759698 2017
36
Use of Low-dose Oral Warfarin in Three Cases of Livedoid Vasculopathy. 61
28979014 2017
37
Efficacy of new low-dose oral anticoagulants in recalcitrant livedoid vasculopathy. 61
28739563 2017
38
Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions. 61
28186689 2017
39
[Livedoid vasculopathy secondary to coeliac disease]. 61
28283193 2017
40
Dabigatran in the management of livedoid vasculopathy. 61
28052437 2017
41
Dermoscopic features of livedoid vasculopathy. 61
28296736 2017
42
Vasculitic and autoimmune wounds. 61
28214498 2017
43
Fast Cicatrization of Extensive Livedoid Vasculopathy Ulcers under Treatment with Sildenafil. 61
28223767 2017
44
Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. 61
27774697 2017
45
Treatment application of rivaroxaban in Chinese patients with livedoid vasculopathy. 61
28360530 2017
46
Rapid remission of severe pain from livedoid vasculopathy by apixaban. 61
27166520 2017
47
[What's new in clinical dermatology?] 61
29429503 2016
48
Anticoagulants in dermatology. 61
27320765 2016
49
Livedoid vasculopathy. 61
27914604 2016
50
Recalcitrant Livedoid Vasculopathy Associated with Hyperhomocysteinaemia Responding to Folic Acid and Vitamins B6/B12 Supplementation. 61
27001413 2016
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Variations for Livedoid Vasculitis

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Expression for Livedoid Vasculitis

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Search GEO for disease gene expression data for Livedoid Vasculitis.
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Pathways for Livedoid Vasculitis

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Pathways related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 12.8 SERPINF2 SERPINE1 SERPINC1 PLG F2
2
Folate Metabolism 1
Show member pathways
 11.89 SERPINE1 PLG MTHFR F2
3
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.56 SERPINF2 SERPINE1 SERPINC1 PLG F2
4
Complement and coagulation cascades 1 36
11.18 SERPINF2 SERPINE1 SERPINC1 PLG F2
5
amb2 Integrin signaling 1
11.11 PLG LPA
6
Syndecan-4-mediated signaling events 1
10.9 PLG F2
7
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 65
10.69 PLG F2
8
Dissolution of Fibrin Clot 65
10.45 SERPINF2 SERPINE1 PLG
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GO Terms for Livedoid Vasculitis

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Cellular components related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 SERPINF2 SERPINE1 SERPINC1 PLG F2 CD40LG
2 platelet alpha granule lumen GO:0031093 9.5 SERPINF2 SERPINE1 PLG
3 blood microparticle GO:0072562 9.46 SERPINF2 SERPINC1 PLG F2
4 collagen-containing extracellular matrix GO:0062023 9.35 SERPINF2 SERPINE1 SERPINC1 PLG F2
5 extracellular region GO:0005576 9.23 SERPINF2 SERPINE1 SERPINC1 PLG LPA F2

Biological processes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.67 SERPINC1 PLG F2
2 platelet degranulation GO:0002576 9.63 SERPINF2 SERPINE1 PLG
3 negative regulation of peptidase activity GO:0010466 9.61 SERPINF2 SERPINE1 SERPINC1
4 cellular protein metabolic process GO:0044267 9.56 SERPINC1 PLG F2 ADA2
5 acute-phase response GO:0006953 9.52 SERPINF2 F2
6 positive regulation of collagen biosynthetic process GO:0032967 9.51 SERPINF2 F2
7 hemostasis GO:0007599 9.5 SERPINC1 PLG F2
8 positive regulation of blood coagulation GO:0030194 9.48 SERPINE1 F2
9 negative regulation of endopeptidase activity GO:0010951 9.46 SERPINF2 SERPINE1 SERPINC1 LPA
10 regulation of blood coagulation GO:0030193 9.4 SERPINC1 F2
11 negative regulation of plasminogen activation GO:0010757 9.37 SERPINF2 SERPINE1
12 fibrinolysis GO:0042730 9.26 SERPINF2 SERPINE1 PLG F2
13 negative regulation of fibrinolysis GO:0051918 8.92 SERPINF2 SERPINE1 PLG F2

Molecular functions related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.58 PLG LPA F2
2 serine-type peptidase activity GO:0008236 9.54 PLG LPA F2
3 endopeptidase inhibitor activity GO:0004866 9.43 SERPINF2 LPA
4 peptidase inhibitor activity GO:0030414 9.43 SERPINF2 SERPINE1 SERPINC1
5 protease binding GO:0002020 9.33 SERPINF2 SERPINE1 SERPINC1
6 apolipoprotein binding GO:0034185 9.32 PLG LPA
7 serine-type endopeptidase inhibitor activity GO:0004867 9.13 SERPINF2 SERPINE1 SERPINC1
8 heparin binding GO:0008201 8.92 SERPINC1 LPA F2 ADA2
Sources

Sources for Livedoid Vasculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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