Livedoid Vasculitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ A rare vascular skin disease characterized by recurrent focal non-inflammatory thrombosis of dermal venulae, predominantly of the lower extremities, resulting in a cutaneous response manifested as pruritus and painful papules and erythematous plaques. The lesions evolve into hemorrhagic vesicles or bullae, which rupture and turn into painful ulcers merging into reticulate, confluent, geometric, and painful ulcerations. During a period of a few months, the ulcerations change to porcelain-white atrophic scars with punctate telangiectasia (so-called atrophie blanche). In active disease, lesions in different stages coexist.

MalaCards based summary: Livedoid Vasculitis, also known as livedoid vasculopathy, is related to vasculitis and homocysteinemia. An important gene associated with Livedoid Vasculitis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Affiliated tissues include skin, endothelial and kidney, and related phenotypes are skin ulcer and anemia

GARD: ¹⁹ Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

Disease Ontology: ¹¹ A vasculitis with purpuric ulcers.

Wikipedia: ⁷⁵ Livedoid vasculopathy is a chronic cutaneous disease seen predominantly in young to middle-aged women.... more...

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Related Diseases for Livedoid Vasculitis

Diseases related to Livedoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 304)

#	Related Disease	Score	Top Affiliating Genes
1	vasculitis	30.9	PRTN3 APOH ADA2
2	homocysteinemia	30.3	MTHFR F2
3	venous insufficiency	30.2	SERPINE1 MTHFR F2
4	hypersensitivity vasculitis	30.1	PRTN3 F2
5	hyperhomocysteinemia	30.0	SERPINE1 SERPINC1 MTHFR F2 APOH
6	polyarteritis nodosa	29.9	PRTN3 APOH ADA2
7	sickle cell anemia	29.9	SERPINC1 F3 F2
8	purpura	29.8	SERPINC1 F3 F2 APOH
9	protein c deficiency	29.8	SERPINE1 SERPINC1 MTHFR F2 APOH
10	mononeuritis multiplex	29.7	PRTN3 APOH ADA2
11	factor v deficiency	29.7	SERPINC1 F3 F2
12	sneddon syndrome	29.6	SERPINC1 F2 APOH ADA2
13	exanthem	29.6	PRTN3 F3 F2
14	prothrombin deficiency	29.3	SERPINC1 F3 F2 APOH
15	chronic venous insufficiency	29.2	SERPINE1 SERPINC1 PLG F3 F2
16	retinal artery occlusion	29.2	SERPINE1 SERPINC1 PLG MTHFR F2 APOH
17	antiphospholipid syndrome	29.1	SERPINE1 SERPINC1 MTHFR F3 F2 APOH
18	deficiency anemia	29.0	SERPINC1 PRTN3 PLG F3 F2
19	thrombophilia due to thrombin defect	29.0	SERPINE1 SERPINC1 MTHFR F3 F2 APOH
20	thrombophilia	29.0	SERPINF2 SERPINE1 SERPINC1 MTHFR F3 F2
21	protein s deficiency	28.8	SERPINE1 SERPINC1 MTHFR F3 F2 APOH
22	thrombophilia due to activated protein c resistance	28.7	SERPINE1 SERPINC1 PLG MTHFR F3 F2
23	antithrombin iii deficiency	28.7	SERPINC1 PLG MTHFR F3 F2 APOH
24	disseminated intravascular coagulation	28.7	SERPINF2 SERPINE1 SERPINC1 PLG F3 F2
25	intracranial thrombosis	28.7	SERPINC1 PLG MTHFR F3 F2 APOH
26	transient cerebral ischemia	28.7	SERPINC1 PLG MTHFR F3 F2 APOH
27	systemic lupus erythematosus	28.5	SERPINC1 PRTN3 PLG F3 F2 APOH
28	central retinal artery occlusion	28.5	SERPINC1 PRTN3 PLG MTHFR F3 F2
29	thrombosis	28.0	SERPINF2 SERPINE1 SERPINC1 PLG MTHFR F3
30	stroke, ischemic	27.5	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG MTHFR
31	skin disease	10.4
32	dowling-degos disease 1	10.4
33	muscular dystrophy, congenital merosin-deficient, 1a	10.4
34	hypolipoproteinemia	10.3
35	telangiectasis	10.3
36	anterior spinal artery syndrome	10.3	PLG F2
37	collagen disease	10.2
38	amaurosis fugax	10.2	SERPINE1 MTHFR
39	premature ovarian failure 19	10.2	SERPINE1 PLG
40	pleural empyema	10.2	PLG F2
41	fibrinolytic defect	10.2	SERPINE1 SERPINC1
42	abducens palsy	10.2	SERPINC1 F2
43	spondyloarthropathy 1	10.1
44	hepatitis b	10.1
45	spondylitis	10.1
46	lateral medullary syndrome	10.1	PRTN3 PLG
47	heparin cofactor ii deficiency	10.1	SERPINC1 PLG
48	splenic tuberculosis	10.1	PRTN3 F2
49	pyuria	10.1	PRTN3 F2
50	encephalopathy, familial, with neuroserpin inclusion bodies	10.1	SERPINC1 PLG

Graphical network of the top 20 diseases related to Livedoid Vasculitis:

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Symptoms & Phenotypes for Livedoid Vasculitis

Human phenotypes related to Livedoid Vasculitis:

⁵⁸ ³⁰ (show all 49)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	skin ulcer ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0200042
2	anemia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001903
3	telangiectasia of the skin ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100585
4	varicose veins ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002619
5	cutis marmorata ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000965
6	elevated erythrocyte sedimentation rate ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003565
7	pedal edema ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0010741
8	abnormality of complement system ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0005339
9	recurrent skin infections ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001581
10	atrophic scars ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001075
11	poor wound healing ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001058
12	hypercoagulability ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100724
13	lower limb pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012514
14	enlargement of the ankles ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003029
15	abnormal thrombosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001977
16	hyperpigmented streaks ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0007572
17	abnormal capillary morphology ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025016
18	diabetes mellitus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000819
19	hypertension ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000822
20	abnormal circulating lipid concentration ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003119
21	paresthesia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003401
22	hyperesthesia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100963
23	reduced antithrombin iii activity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001976
24	reduced protein c activity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0005543
25	erythematous papule ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0030350
26	ecchymosis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0031364
27	antinuclear antibody positivity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003493
28	lupus anticoagulant ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0025343
29	superficial dermal perivascular inflammatory infiltrate ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0031190
30	hyperhomocystinemia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002160
31	reduced protein s activity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0004855
32	abnormality of the peripheral nervous system ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0410008
33	multiple mononeuropathy ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0032018
34	reduced plasminogen activator inhibitor 1 activity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0040248
35	abnormal foot morphology ³⁰	Occasional (7.5%)		HP:0001760
36	polycythemia ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001901
37	pancytopenia ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001876
38	leukocytosis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001974
39	graves disease ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0100647
40	systemic lupus erythematosus ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002725
41	ischemic stroke ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002140
42	allergy ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0012393
43	autoimmunity ⁵⁸		Frequent (79-30%)
44	abnormality of the foot ⁵⁸		Occasional (29-5%)
45	venous insufficiency ⁵⁸		Occasional (29-5%)
46	abnormality of the lower limb ⁵⁸		Very frequent (99-80%)
47	hyperpigmentation of the skin ⁵⁸		Frequent (79-30%)
48	macular purpura ⁵⁸		Occasional (29-5%)
49	abnormality of fibrinolysis ⁵⁸		Occasional (29-5%)

GenomeRNAi Phenotypes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

²⁵ (show all 22)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-106	9.66	ADA2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-107	9.66	ADA2
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-111	9.66	ADA2
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-119	9.66	PRTN3
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-133	9.66	PRTN3
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-134	9.66	ADA2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.66	PRTN3
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-173	9.66	MTHFR
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-179	9.66	PRTN3
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-18	9.66	ADA2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-180	9.66	MTHFR
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.66	ADA2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-209	9.66	PRTN3
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.66	MTHFR
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.66	MTHFR
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-48	9.66	ADA2
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-6	9.66	MTHFR
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-76	9.66	MTHFR
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-80	9.66	ADA2
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-82	9.66	PRTN3
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-97	9.66	ADA2
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.66	PRTN3

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Drugs & Therapeutics for Livedoid Vasculitis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Correlation of Genetic Polymorphism and Livedo Vasculitis	Completed	NCT00975871

Search NIH Clinical Center for Livedoid Vasculitis

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Genetic Tests for Livedoid Vasculitis

Genetic tests related to Livedoid Vasculitis:

#	Genetic test	Affiliating Genes
1	Livedoid Vasculopathy ²⁸

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Anatomical Context for Livedoid Vasculitis

Organs/tissues related to Livedoid Vasculitis:

MalaCards : Skin, Endothelial, Kidney

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Publications for Livedoid Vasculitis

Articles related to Livedoid Vasculitis:

(show top 50) (show all 317)

#	Title	Authors	PMID	Year
1	Botulinum toxin-A: A novel treatment for livedoid vasculopathy. ⁶²	Crotty AM...Wright KT	36186404	2022
2	Immunosuppression use in primary antiphospholipid antibody-positive patients: Descriptive analysis of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ("Registry"). ⁶²	Erton ZB...Erkan D	36206383	2022
3	Livedoid Vasculopathy Associated With Plasminogen Activator Inhibitor-1 Polymorphisms Treated With Factor Xa Inhibitors. ⁶²	Bouceiro-Mendes R...Filipe P	35636505	2022
4	Livedoid Vasculopathy Associated With Plasminogen Activator Inhibitor-1 Polymorphisms Treated With Factor Xa Inhibitors. ⁶²	Bouceiro-Mendes R...Filipe P	35952920	2022
5	Efficacy of adalimumab in the treatment of refractory livedoid vasculopathy: Case report and literature review. ⁶²	Dong L...Zhang X	35760761	2022
6	Excellent Long-term Clinical Response to Rivaroxaban in Livedoid Vasculopathy: A Retrospective Study. ⁶²	Morgado-Carrasco D...Mascaro-Galy JM	36115384	2022
7	Platelet count and plateletcrit: Potential haematological biomarkers for livedoid vasculopathy? ⁶²	Gao Y...Jin H	35635484	2022
8	Comparative Efficacy of Rivaroxaban and Immunoglobulin Therapy in the Treatment of Livedoid Vasculopathy: A Systematic Review. ⁶²	Ramphall S...Venugopal S	36051980	2022
9	Refractory livedoid vasculopathy in a child successfully treated with baricitinib. ⁶²	Zhang H...Liu Y	35726859	2022
10	A novel combination ("CHAP") regimen for management of livedoid vasculopathy in 12 patients. ⁶²	Coromilas AJ...Micheletti RG	35787412	2022
11	Peripheral neuropathy and livedoid vasculopathy. ⁶²	Soulages A...Mathis S	35166926	2022
12	Patients with laboratory criteria of anti-phospholipid syndrome and 'non-criteria' manifestations: a multicenter cohort. ⁶²	Pires da Rosa G...Cervera R	35723613	2022
13	Treatment of Livedoid Vasculopathy With Baricitinib. ⁶²	Song X...Tu P	35353137	2022
14	Adalimumab in Treating Refractory Livedoid Vasculopathy. ⁶²	Huang XW...Li L	35455298	2022
15	Efficacy of an anti-TNF-alpha agent in refractory livedoid vasculopathy: a retrospective analysis. ⁶²	Gao Y...Jin H	32116074	2022
16	Exacerbation of livedoid vasculopathy after coronavirus disease 2019. ⁶²	Kawabe R...Fujimoto M	35171794	2022
17	Medium-pressure hyperbaric oxygen therapy for livedoid vasculopathy. ⁶²	Herrera-Sanchez A...Verdini F	35904919	2022
18	Efficacy and safety of intravenous immunoglobulin for treating refractory livedoid vasculopathy: a systematic review. ⁶²	Gao Y...Jin H	35634570	2022
19	Exacerbation of livedoid vasculopathy after coronavirus disease 2019. ⁶²	Kawabe R...Fujimoto M	35766079	2022
20	Exacerbation of livedoid vasculopathy after coronavirus disease 2019. ⁶²	Kawabe R...Fujimoto M	35653093	2022
21	Livedoid vasculopathy - A diagnostic and therapeutic challenge. ⁶²	Burg MR...Schneider SW	36262273	2022
22	Livedoid Vasculitis in a Patient With Sjogren Syndrome Successfully Treated With Methotrexate. ⁶²	Aldehaim AY...Alarfaj AS	35342318	2022
23	Real-world data on pain management and effectiveness of anti-tumour necrosis factor agents in refractory livedoid vasculopathy. ⁶²	Gao Y...Jin H	34416092	2022
24	Primary and Secondary Livedoid Vasculopathy: A Report of 2 Cases. ⁶²	AboElnasr LS...Aiad HAS	34889819	2022
25	Livedoid vasculopathy: A multidisciplinary clinical approach to diagnosis and management. ⁶²	Bilgic A...Alpsoy E	35024414	2021
26	Livedoid vasculopathy and its association with genetic variants: A systematic review. ⁶²	Gao Y...Jin H	33686673	2021
27	Rivaroxaban for treatment of livedoid vasculopathy: A systematic review. ⁶²	Gao Y...Jin H	34197012	2021
28	Intravenous Immunoglobulin Therapy in Livedoid Vasculopathy: Retrospective Observation of Clinical Outcome and Patient's Activity Level. ⁶²	Kofler K...Kofler L	33779349	2021
29	An Observational Study of Mucocutaneous Manifestations among SARS-CoV-2 Patients from Three COVID-19 Dedicated Tertiary Care Centers. ⁶²	Mohta A...Bha Rgava G	34667754	2021
30	A novel use of intermittent low dose dabigatran for maintenance of remission in livedoid vasculopathy. ⁶²	Rajan M B...Agrawal A	34028946	2021
31	Cutaneous involvement by T-cell prolymphocytic leukemia presenting as livedoid vasculopathy. ⁶²	Leckey BD...Al-Rohil RN	33837964	2021
32	Livedoid vasculopathy: A challenging disease to diagnose. ⁶²	Kurt T...Acar B	32619286	2021
33	Recrudescence of livedoid vasculopathy induced by COVID-19. ⁶²	Valentim FO...Miot HA	33527356	2021
34	Direct immunofluorescence findings in livedoid vasculopathy: a 10-year study and literature review. ⁶²	Nuttawong S...Rujitharanawong C	32986882	2021
35	Methylene tetrahydrofolate reductase C677T polymorphism in Korean livedoid vasculopathy patients. ⁶²	Lee JS...Cho S	32599117	2021
36	Livedoid vasculopathy in 75 Brazilian patients in a single-center institution: Clinical, histopathological and therapy evaluation. ⁶²	Criado PR...Sotto MN	33496999	2021
37	Remission of long-standing livedoid vasculopathy using a whole foods plant-based diet with symptoms recurrent on re-challenge with standard Western diet. ⁶²	Smith M...Duncan B	33622761	2021
38	Livedoid vasculopathy: Clinical course and long-term outcome in Asian patients with a review of the literature. ⁶²	Rujitharanawong C...Nuttawong S	33219608	2021
39	From dermatological conditions to COVID-19: Reasoning for anticoagulation, suppression of inflammation, and hyperbaric oxygen therapy. ⁶²	Criado PR...Fabro AT	33219572	2021
40	Plasminogen activator inhibitor-1: a potential etiological role in livedoid vasculopathy. ⁶²	Gao Y...Jin H	33043622	2020
41	Livedoid Vasculopathy Associated with Antiphospholipid Antibody Presenting with Leg Ulcer. ⁶²	Kapur SV...Oswal JS	32451825	2020
42	A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide. ⁶²	Song CH...Seo HM	33911794	2020
43	Refractory ulcerations associated with livedoid vasculopathy successfully treated with tofacitinib. ⁶²	Jia E...Zhang J	33112475	2020
44	Unraveling the mystery of Covid-19 cytokine storm: From skin to organ systems. ⁶²	Garg S...Agarwal R	32559324	2020
45	[Diagnosis and treatment of vasculitic ulcerations]. ⁶²	Mitschang C...Gorge T	32997218	2020
46	[Non-healing wounds]. ⁶²	van Erp FC...van Montfrans C	33201630	2020
47	Vasculitic mononeuritis multiplex associated with livedoid vasculopathy. ⁶²	Corral I...Pian H	31771777	2020
48	Intravenous Immunoglobulins in a Series of 32 Rare and Recalcitrant Immune Dermatoses. ⁶²	Scarpone R...Worm M	33047147	2020
49	Clinical and dermoscopic features of livedoid vasculopathy. ⁶²	Wen J...Yu JB	32804736	2020
50	Primary livedoid vasculopathy associated with mononeuritis multiplex. ⁶²	Krueger S...Belazarian L	32898400	2020

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Genes for Livedoid Vasculitis

Genes related to Livedoid Vasculitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	F2	Coagulation Factor II, Thrombin	Protein Coding	6.13	DISEASES inferred ¹⁴
2	SERPINE1	Serpin Family E Member 1	Protein Coding	5.89	DISEASES inferred ¹⁴
3	PLG	Plasminogen	Protein Coding	5.79	DISEASES inferred ¹⁴
4	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	5.66	DISEASES inferred ¹⁴
5	ADA2	Adenosine Deaminase 2	Protein Coding	5.49	DISEASES inferred ¹⁴
6	SERPINC1	Serpin Family C Member 1	Protein Coding	5.42	DISEASES inferred ¹⁴
7	APOH	Apolipoprotein H	Protein Coding	5.03	DISEASES inferred ¹⁴
8	SERPINF2	Serpin Family F Member 2	Protein Coding	4.34	DISEASES inferred ¹⁴
9	F3	Coagulation Factor III, Tissue Factor	Protein Coding	4.29	DISEASES inferred ¹⁴
10	PRTN3	Proteinase 3	Protein Coding	4.15	DISEASES inferred ¹⁴

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Variations for Livedoid Vasculitis

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Expression for Livedoid Vasculitis

Search GEO for disease gene expression data for Livedoid Vasculitis.

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Pathways for Livedoid Vasculitis

Pathways related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways "Platelet activation, signaling and aggregation" ⁶⁶ Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet degranulation ⁶⁶	12.62	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG F3
2	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	11.95	SERPINC1 PLG F2
3	Diseases of hemostasis ⁶⁶ Show member pathways Blood clotting cascade ⁷⁴ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Complement and coagulation cascades ⁷⁴ Defective F8 binding to von Willebrand factor ⁶⁶ Defective F8 cleavage by thrombin ⁶⁶ Defective F8 sulfation at Y1699 ⁶⁶ Defective F9 activation ⁶⁶ Defective F9 secretion ⁶⁶ Defective factor IX causes hemophilia B ⁶⁶ Defective factor VIII causes hemophilia A ⁶⁶ Defective factor XII causes hereditary angioedema ⁶⁶ Defective gamma-carboxylation of F9 ⁶⁶ Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶ Thrombin/protease-activated receptor (PAR) pathway ⁶¹	11.63	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG F3
4	Adhesion ³	11.59	SERPINE1 PLG F3
5	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ⁶¹	11.05	SERPINE1 PLG
6	"Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction" ⁶⁰	11	F3 F2
7	Syndecan-4-mediated signaling events ⁶¹	10.86	PLG F2
8	Dissolution of Fibrin Clot ⁶⁶	10.45	SERPINF2 SERPINE1 PLG
9	"COVID-19, thrombosis and anticoagulation" ⁷⁴	10.1	PLG F2

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GO Terms for Livedoid Vasculitis

Cellular components related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.09	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG F3
2	extracellular space	GO:0005615	9.91	ADA2 APOH F2 F3 PLG PRTN3
3	blood microparticle	GO:0072562	9.86	SERPINF2 SERPINC1 PLG F2
4	platelet alpha granule lumen	GO:0031093	9.8	SERPINF2 SERPINE1 PLG
5	collagen-containing extracellular matrix	GO:0062023	9.53	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG F3

Biological processes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:0007596	9.97	SERPINC1 PLG F3 F2
2	negative regulation of endopeptidase activity	GO:0010951	9.95	SERPINF2 SERPINE1 SERPINC1
3	positive regulation of blood coagulation	GO:0030194	9.8	APOH F2 SERPINE1
4	negative regulation of blood coagulation	GO:0030195	9.76	SERPINE1 APOH
5	negative regulation of plasminogen activation	GO:0010757	9.73	SERPINF2 SERPINE1
6	negative regulation of peptidase activity	GO:0010466	9.58	SERPINF2 SERPINE1 SERPINC1
7	regulation of blood coagulation	GO:0030193	9.56	SERPINC1 F2 APOH
8	fibrinolysis	GO:0042730	9.56	SERPINF2 SERPINE1 PLG F2
9	hemostasis	GO:0007599	9.46	SERPINC1 PLG F3 F2
10	negative regulation of fibrinolysis	GO:0051918	9.32	SERPINF2 SERPINE1 PLG F2 APOH

Molecular functions related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	10.01	SERPINE1 PRTN3 PLG F2
2	serine-type endopeptidase inhibitor activity	GO:0004867	9.8	SERPINF2 SERPINE1 SERPINC1
3	serine-type peptidase activity	GO:0008236	9.77	PRTN3 PLG F2
4	serine-type endopeptidase activity	GO:0004252	9.76	F2 F3 PLG PRTN3
5	heparin binding	GO:0008201	9.56	SERPINC1 F2 APOH ADA2
6	peptidase inhibitor activity	GO:0030414	9.43	SERPINF2 SERPINE1 SERPINC1
7	protease binding	GO:0002020	9.23	SERPINF2 SERPINE1 SERPINC1 F3

Sources

Sources for Livedoid Vasculitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LVD003 MIFTS: 46	Livedoid Vasculitis Categories: Cardiovascular diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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Livedoid Vasculitis

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