Livedoid Vasculitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LVD003 MIFTS: 39	Livedoid Vasculitis Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Livedoid Vasculitis

MalaCards integrated aliases for Livedoid Vasculitis:

Name: Livedoid Vasculitis ¹² ⁵³ ¹⁵ ³³

Livedoid Vasculopathy ¹² ⁵³ ⁵⁹

Livedo Reticularis with Summer Ulcerations ⁵³ ⁵⁹

Livedo Reticularis with Winter Ulcerations ⁵³

Segmental Hyalinizing Vasculopathy ⁵³

Segmental Hyalinizing Vasculitis ⁵⁹

Milian Atrophie Blanche ⁵⁹

Livedo Vasculitis ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the skin and subcutaneous tissue

Other disorders of the skin and subcutaneous tissue

Vasculitis limited to skin, not elsewhere classified

Livedoid vasculitis

Orphanet: ⁵⁹

Rare circulatory system diseases

Rare skin diseases

External Ids:

Disease Ontology ¹² DOID:0040099

ICD9CM ³⁵ 709.1

ICD10 ³³ L95.0

Orphanet ⁵⁹ ORPHA542643

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Summaries for Livedoid Vasculitis

NIH Rare Diseases : ⁵³ Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

MalaCards based summary : Livedoid Vasculitis, also known as livedoid vasculopathy, is related to purpura and protein c deficiency. An important gene associated with Livedoid Vasculitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include skin and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : ¹² A vasculitis with purpuric ulcers.

Wikipedia : ⁷⁵ Livedoid vasculopathy is a chronic cutaneous disease seen predominantly in young to middle-aged women.... more...

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Related Diseases for Livedoid Vasculitis

Diseases related to Livedoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)

#	Related Disease	Score	Top Affiliating Genes
1	purpura	31.1	SERPINC1 F2 APOH
2	protein c deficiency	31.1	SERPINC1 MTHFR F2
3	sticky platelet syndrome	31.0	SERPINE1 SERPINC1
4	ischemic neuropathy	30.8	MTHFR F2
5	homocysteinemia	30.7	SERPINC1 MTHFR F2
6	antiphospholipid syndrome	30.5	SERPINC1 MTHFR F2 APOH
7	polyarteritis nodosa	30.5	PRTN3 APOH ADA2
8	disseminated intravascular coagulation	30.5	SERPINF2 SERPINE1 SERPINC1 F2
9	branch retinal artery occlusion	30.3	SERPINC1 MTHFR F2 APOH
10	protein s deficiency	30.3	SERPINC1 MTHFR F2 APOH
11	antithrombin iii deficiency	30.2	SERPINC1 MTHFR F2 APOH
12	sneddon syndrome	30.1	SERPINC1 F2 APOH ADA2
13	thrombophilia	29.8	SERPINE1 SERPINC1 MTHFR F8 F2 APOH
14	thrombophilia due to thrombin defect	29.4	SERPINE1 SERPINC1 MTHFR F8 F2 APOH
15	intracranial thrombosis	29.4	SERPINC1 PLG MTHFR F8 APOH
16	retinal artery occlusion	29.2	SERPINE1 SERPINC1 MTHFR F8 F2 APOH
17	thrombosis	29.2	SERPINE1 SERPINC1 MTHFR F8 F2 APOH
18	thrombophilia due to activated protein c resistance	28.7	SERPINF2 SERPINE1 SERPINC1 PLG MTHFR F8
19	stroke, ischemic	28.7	SERPINF2 SERPINE1 SERPINC1 PLG MTHFR LPA
20	vasculitis	10.8
21	fibrinolytic defect	10.7	SERPINE1 SERPINC1
22	cerebral falx meningioma	10.6	PLG F2
23	platelet aggregation, spontaneous	10.6	SERPINF2 SERPINC1
24	sagittal sinus thrombosis	10.6	SERPINC1 F2
25	plasminogen activator inhibitor-1 deficiency	10.6	SERPINF2 SERPINE1
26	argentine hemorrhagic fever	10.6	SERPINE1 SERPINC1
27	aspirin allergy	10.6	SERPINE1 SERPINC1
28	cold urticaria	10.6	SERPINF2 SERPINC1
29	mesenteric vascular occlusion	10.6	MTHFR F2
30	amaurosis fugax	10.6	SERPINE1 MTHFR
31	neonatal stroke	10.6	SERPINE1 MTHFR
32	tuberculous empyema	10.5	SERPINE1 PLG
33	femoral neuropathy	10.5	PLG F2
34	purpura fulminans	10.5	SERPINF2 SERPINC1 F2
35	leech infestation	10.5	SERPINC1 PLG F2
36	anterior spinal artery syndrome	10.5	SERPINC1 PLG F2
37	lateral sinus thrombosis	10.5	PDGFB MTHFR
38	subendocardial myocardial infarction	10.5	SERPINE1 SERPINC1 F2
39	cerebral sinovenous thrombosis	10.5	F2 APOH
40	eclampsia	10.5	SERPINC1 MTHFR F2
41	anterior cranial fossa meningioma	10.5	PLG F2
42	acute poststreptococcal glomerulonephritis	10.5	SERPINF2 PLG
43	skin disease	10.4
44	blood protein disease	10.4	SERPINC1 MTHFR F2
45	acute cor pulmonale	10.4	SERPINF2 SERPINE1 PLG
46	acute pulmonary heart disease	10.4	SERPINF2 SERPINE1 PLG
47	hepatic veno-occlusive disease	10.4	SERPINE1 SERPINC1 PLG
48	nonarteritic anterior ischemic optic neuropathy	10.4	SERPINC1 MTHFR F2
49	cryptogenic cirrhosis	10.4	SERPINE1 MTHFR F2
50	varicose veins	10.4	SERPINC1 MTHFR F2

Graphical network of the top 20 diseases related to Livedoid Vasculitis:

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Symptoms & Phenotypes for Livedoid Vasculitis

MGI Mouse Phenotypes related to Livedoid Vasculitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.02	C3 CALCR CCNA2 F2 F8 PDGFB
2	homeostasis/metabolism	MP:0005376	10	APOH C3 CALCR F2 F8 MTHFR
3	immune system	MP:0005387	9.85	C3 CALCR CCNA2 F2 F8 PDGFB
4	liver/biliary system	MP:0005370	9.43	C3 MTHFR PDGFB PLG SERPINC1 SERPINE1
5	mortality/aging	MP:0010768	9.36	APOH C3 CALCR CCNA2 F2 F8

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Drugs & Therapeutics for Livedoid Vasculitis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Correlation of Genetic Polymorphism and Livedo Vasculitis	Completed	NCT00975871

Search NIH Clinical Center for Livedoid Vasculitis

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Genetic Tests for Livedoid Vasculitis

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Anatomical Context for Livedoid Vasculitis

MalaCards organs/tissues related to Livedoid Vasculitis:

⁴¹

Skin, Endothelial

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Publications for Livedoid Vasculitis

Articles related to Livedoid Vasculitis:

(show top 50) (show all 212)

#	Title	Authors	PMID	Year
1	Topical becaplermin gel is an effective adjuvant for long-standing ulcers of livedoid vasculopathy recalcitrant to anticoagulant therapy. ³⁸	Mushtaq S...Mudugal R	30706539	2019
2	Retiform non-blanchable purpuric plaques in a patient with systemic lupus erythematosus. ³⁸	Grinnell M...Hearth-Holmes M	31126212	2019
3	Livedoid vasculopathy: does hyperhomocysteinaemia play an aetiological role? ³⁸	Marsch WC...Hoffmann K	31389788	2019
4	Characteristics, risk factors and treatment reality in livedoid vasculopathy - a multicentre analysis. ³⁸	Weishaupt C...Goerge T	31009111	2019
5	Livedoid vasculopathy presenting with leg ulcers. ³⁸	Kumar A...Agarwal A	31220328	2019
6	Prevention of recurrent ulceration of livedoid vasculopathy with long-term apixaban monotherapy. ³⁸	Osada SI...Manabe M	30156315	2019
7	Endovenous Laser Ablation Treatment for Lower Extremity Ulcers Associated With Livedoid Vasculopathy. ³⁸	Chow M...Wysong A	30882502	2019
8	Chronic leg ulcerations associated with livedoid vasculopathy successfully treated with rivaroxaban. ³⁸	Miguel D...Goetze S	30767258	2019
9	Systemic lupus erythematosus with refractory ulcerated livedoid vasculopathy: Successful treatment with intravenous immunoglobulin and warfarin. ³⁸	Yoshioka K...Chen KR	30455888	2018
10	Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options. ³⁸	Gardette E...Barete S	29738044	2018
11	Traditional Korean medicine treatment for livedoid vasculopathy: Five case reports. ³⁸	Lee JA...Park S	30100128	2018
12	Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease. ³⁸	Reagin H...Susa J	29533274	2018
13	Dermoscopy of early non-ulcerated livedoid vasculopathy. ³⁸	Wollina U	30244265	2018
14	Livedoid vasculopathy: a compelling diagnosis. ³⁸	Freitas TQ...Criado PR	30101138	2018
15	Systemic therapies for leg ulcers. ³⁸	Dissemond J...Reich-Schupke S	29989361	2018
16	The management of livedoid vasculopathy focused on direct oral anticoagulants (DOACs): four case reports successfully treated with rivaroxaban. ³⁸	Franco Marques G...Cajas Garcia MS	29663354	2018
17	Three cases of lymphocytic thrombophilic arteritis presenting with an annular eruption. ³⁸	Kelly RI...Williams RA	28752544	2018
18	Treatment of Livedoid Vasculopathy With Rivaroxaban: A Potential Use of New Oral Anticoagulants for Dermatologists. ³⁸	Jimenez-Gallo D...Linares-Barrios M	29074145	2018
19	Livedoid vasculopathy in a patient with bullous pemphigoid and primary Sjögren's syndrome. ³⁸	Garcia Briz MI...Mateu Puchades A	29526676	2018
20	Ulcerative livedoid vasculopathy responding to clopidogrel. ³⁸	Kunzler E...Chong BF	29892667	2018
21	Treatment for Livedoid Vasculopathy: A Systematic Review. ³⁸	Micieli R...Alavi A	29141075	2018
22	Systemic Lupus Erythematosus Presenting as Livedoid Vasculopathy over the Forearms. ³⁸	Yadav P...Singh D	29911533	2018
23	Vasculopathies, cutaneous necrosis and emergency in dermatology. ³⁸	Martinez-Mera C...Llamas-Velasco M	28845953	2017
24	Prevention of livedoid vasculopathy recurrence by prolonged administration of rivaroxaban. ³⁸	Drerup C...Goerge T	28609556	2017
25	Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy. ³⁸	Espinel DPGS...Criado PR	28901563	2017
26	Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis. ³⁸	Renner R...Erfurt-Berge C	28252815	2017
27	Livedoid Vasculopathy. ³⁸	Zampeli E...Moutsopoulos HM	28511282	2017
28	Occlusive Nonvasculitic Vasculopathy. ³⁸	Llamas-Velasco M...Requena L	27759698	2017
29	Use of Low-dose Oral Warfarin in Three Cases of Livedoid Vasculopathy. ³⁸	Saoji V...Madke B	28979014	2017
30	Efficacy of new low-dose oral anticoagulants in recalcitrant livedoid vasculopathy. ³⁸	Furukawa F...Shimizu T	28739563	2017
31	Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions. ³⁸	Agirbasli M...Akkiprik M	28186689	2017
32	[Livedoid vasculopathy secondary to coeliac disease]. ³⁸	Henry J...Valois A	28283193	2017
33	Dabigatran in the management of livedoid vasculopathy. ³⁸	Sawada T...Suehiro M	28052437	2017
34	Dermoscopic features of livedoid vasculopathy. ³⁸	Hu SC...Lin YS	28296736	2017
35	Vasculitic and autoimmune wounds. ³⁸	Shanmugam VK...McNish S	28214498	2017
36	Fast Cicatrization of Extensive Livedoid Vasculopathy Ulcers under Treatment with Sildenafil. ³⁸	Lopes LM...Bredemeier M	28223767	2017
37	Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. ³⁸	Nakayama T...Watanabe D	27774697	2017
38	Rapid remission of severe pain from livedoid vasculopathy by apixaban. ³⁸	Yamaguchi Y...Shimizu H	27166520	2017
39	Treatment application of rivaroxaban in Chinese patients with livedoid vasculopathy. ³⁸	Chen W...Deng X	28360530	2017
40	[What's new in clinical dermatology?] ³⁸	Lok C	29429503	2016
41	Anticoagulants in dermatology. ³⁸	Adya KA...Palit A	27320765	2016
42	Livedoid vasculopathy. ³⁸	Provenza JR...Provenza GM	27914604	2016
43	Recalcitrant Livedoid Vasculopathy Associated with Hyperhomocysteinaemia Responding to Folic Acid and Vitamins B6/B12 Supplementation. ³⁸	Errichetti E...Stinco G	27001413	2016
44	Livedoid vasculopathy: A review of pathogenesis and principles of management. ³⁸	Vasudevan B...Verma R	27297279	2016
45	Livedoid Vasculopathy Associated with HIV Infection in Two Patients: A Causal Relationship? ³⁸	Hurabielle C...Barete S	26778817	2016
46	Livedoid vasculopathy - a challenging disease. ³⁸	Vieira R...Costa L	27155327	2016
47	Case series of recalcitrant livedoid vasculopathy treated with rivaroxaban. ³⁸	Lee JM...Kim IH	26993107	2016
48	Cilostazol: A novel agent in recalcitrant livedoid vasculopathy. ³⁸	Mendiratta V...Nangia A	26345653	2016
49	New hope for patients with livedoid vasculopathy. ³⁸	Kirsner RS	26853641	2016
50	Livedoid vasculopathy. ³⁸	Provenza JR...Provenza GM	26952873	2016

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Genes for Livedoid Vasculitis

Genes related to Livedoid Vasculitis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SERPINC1	Serpin Family C Member 1	Protein Coding	21.17	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	SERPINF2	Serpin Family F Member 2	Protein Coding	20.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	F2	Coagulation Factor II, Thrombin	Protein Coding	16.12	DISEASES inferred ¹⁵
4	LPA	Lipoprotein(A)	Protein Coding	15.47	DISEASES inferred ¹⁵
5	PLG	Plasminogen	Protein Coding	15.35	DISEASES inferred ¹⁵
6	SERPINE1	Serpin Family E Member 1	Protein Coding	15.31	DISEASES inferred ¹⁵
7	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	15.24	DISEASES inferred ¹⁵
8	ADA2	Adenosine Deaminase 2	Protein Coding	14.99	DISEASES inferred ¹⁵
9	CALCR	Calcitonin Receptor	Protein Coding	14.03	DISEASES inferred ¹⁵
10	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	13.52	DISEASES inferred ¹⁵
11	APOH	Apolipoprotein H	Protein Coding	13.37	DISEASES inferred ¹⁵
12	C3	Complement C3	Protein Coding	13.23	DISEASES inferred ¹⁵
13	F8	Coagulation Factor VIII	Protein Coding	13.22	DISEASES inferred ¹⁵
14	CCNA2	Cyclin A2	Protein Coding	13.09	DISEASES inferred ¹⁵
15	GTPBP1	GTP Binding Protein 1	Protein Coding	4.61	DISEASES inferred ¹⁵
16	PRTN3	Proteinase 3	Protein Coding	2.98	DISEASES inferred ¹⁵

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Variations for Livedoid Vasculitis

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Expression for Livedoid Vasculitis

Search GEO for disease gene expression data for Livedoid Vasculitis.

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Pathways for Livedoid Vasculitis

Pathways related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.89	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG PDGFB
2	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.96	SERPINE1 PLG MTHFR F2
3	Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶	11.7	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG F8
4	Complement and coagulation cascades ³⁷ ¹	11.31	SERPINF2 SERPINE1 SERPINC1 PLG F8 F2
5	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶	10.69	PLG F2
6	Dissolution of Fibrin Clot ⁶⁶	10.55	SERPINF2 SERPINE1 PLG

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GO Terms for Livedoid Vasculitis

Cellular components related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.77	SERPINC1 PDGFB F8 F2 C3
2	extracellular region	GO:0005576	9.73	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG PDGFB
3	blood microparticle	GO:0072562	9.72	SERPINF2 SERPINC1 PLG F2 C3
4	azurophil granule lumen	GO:0035578	9.61	PRTN3 C3 ADA2
5	platelet alpha granule lumen	GO:0031093	9.55	SERPINF2 SERPINE1 PLG PDGFB F8
6	collagen-containing extracellular matrix	GO:0062023	9.17	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG PDGFB
7	extracellular exosome	GO:0070062	10.01	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG F2
8	extracellular space	GO:0005615	10	SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG PDGFB

Biological processes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein metabolic process	GO:0044267	9.88	SERPINC1 PLG F2 C3 ADA2
2	proteolysis	GO:0006508	9.86	PRTN3 PLG LPA F2
3	blood coagulation	GO:0007596	9.83	SERPINC1 PRTN3 PLG F8 F2
4	negative regulation of peptidase activity	GO:0010466	9.72	SERPINF2 SERPINE1 SERPINC1
5	acute-phase response	GO:0006953	9.67	SERPINF2 F8 F2
6	negative regulation of endopeptidase activity	GO:0010951	9.65	SERPINF2 SERPINE1 SERPINC1 LPA C3
7	blood coagulation, intrinsic pathway	GO:0007597	9.63	F8 F2 APOH
8	hemostasis	GO:0007599	9.62	SERPINC1 PLG F8 F2
9	regulation of blood coagulation	GO:0030193	9.58	SERPINC1 F2 APOH
10	positive regulation of collagen biosynthetic process	GO:0032967	9.57	SERPINF2 F2
11	negative regulation of blood coagulation	GO:0030195	9.54	SERPINE1 APOH
12	positive regulation of blood coagulation	GO:0030194	9.54	SERPINE1 F2 APOH
13	negative regulation of platelet activation	GO:0010544	9.52	PDGFB F2
14	negative regulation of plasminogen activation	GO:0010757	9.51	SERPINF2 SERPINE1
15	fibrinolysis	GO:0042730	9.46	SERPINF2 SERPINE1 PLG F2
16	platelet degranulation	GO:0002576	9.43	SERPINF2 SERPINE1 PLG PDGFB F8 APOH
17	negative regulation of fibrinolysis	GO:0051918	9.02	SERPINF2 SERPINE1 PLG F2 APOH

Molecular functions related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.72	SERPINE1 PRTN3 PLG F2 C3
2	peptidase inhibitor activity	GO:0030414	9.63	SERPINF2 SERPINE1 SERPINC1
3	protease binding	GO:0002020	9.58	SERPINF2 SERPINE1 SERPINC1
4	serine-type peptidase activity	GO:0008236	9.56	PRTN3 PLG LPA F2
5	serine-type endopeptidase inhibitor activity	GO:0004867	9.54	SERPINF2 SERPINE1 SERPINC1
6	apolipoprotein binding	GO:0034185	9.43	PLG LPA
7	endopeptidase inhibitor activity	GO:0004866	9.33	SERPINF2 LPA C3
8	serine-type endopeptidase activity	GO:0004252	9.26	PRTN3 PLG LPA F2
9	heparin binding	GO:0008201	9.02	SERPINC1 LPA F2 APOH ADA2

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Sources for Livedoid Vasculitis

¹ BioSystems

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²⁰ GeneAnalytics

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²² GeneGo (Thomson Reuters)

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²⁶ GenomeRNAi

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⁵¹ NDF-RT

⁵² NIH Clinical Center

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⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

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⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia