MCID: LVD003
MIFTS: 43

Livedoid Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Skin diseases

Aliases & Classifications for Livedoid Vasculitis

MalaCards integrated aliases for Livedoid Vasculitis:

Name: Livedoid Vasculitis 12 54 15
Livedoid Vasculopathy 12 54
Livedo Reticularis with Summer Ulcerations 54
Livedo Reticularis with Winter Ulcerations 54
Segmental Hyalinizing Vasculopathy 54
Livedo Vasculitis 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0040099
ICD9CM 36 709.1
ICD10 34 L95.0

Summaries for Livedoid Vasculitis

NIH Rare Diseases : 54 Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

MalaCards based summary : Livedoid Vasculitis, also known as livedoid vasculopathy, is related to protein c deficiency and ischemic neuropathy. An important gene associated with Livedoid Vasculitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include skin and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A vasculitis with purpuric ulcers.

Wikipedia : 77 Livedoid vasculopathy is a chronic cutaneous disease seen predominantly in young to middle-aged women.... more...

Related Diseases for Livedoid Vasculitis

Diseases related to Livedoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 protein c deficiency 30.5 F2 MTHFR SERPINC1
2 ischemic neuropathy 30.5 F2 MTHFR
3 homocysteinemia 30.4 F2 MTHFR SERPINC1
4 antiphospholipid syndrome 30.4 APOH F2 MTHFR SERPINC1
5 protein s deficiency 30.2 APOH F2 MTHFR SERPINC1
6 antithrombin iii deficiency 30.2 APOH F2 MTHFR SERPINC1
7 sneddon syndrome 30.0 ADA2 APOH F2 SERPINC1
8 thrombophilia 29.9 APOH F2 F8 MTHFR SERPINC1 SERPINE1
9 intracranial thrombosis 29.7 APOH F8 MTHFR PLG SERPINC1
10 retinal artery occlusion 29.6 APOH F2 F8 MTHFR SERPINC1 SERPINE1
11 thrombosis 29.6 APOH F2 F8 MTHFR SERPINC1 SERPINE1
12 vasculitis 10.7
13 fibrinolytic defect 10.4 SERPINC1 SERPINE1
14 cerebral falx meningioma 10.4 F2 PLG
15 plasminogen activator inhibitor-1 deficiency 10.4 SERPINE1 SERPINF2
16 platelet aggregation, spontaneous 10.4 SERPINC1 SERPINF2
17 aspirin allergy 10.4 SERPINC1 SERPINE1
18 argentine hemorrhagic fever 10.4 SERPINC1 SERPINE1
19 sticky platelet syndrome 10.4 SERPINC1 SERPINE1
20 sagittal sinus thrombosis 10.4 F2 SERPINC1
21 inferior vena cava interruption 10.4 MTHFR SERPINE1
22 mesenteric vascular occlusion 10.4 F2 MTHFR
23 neonatal stroke 10.4 MTHFR SERPINE1
24 cold urticaria 10.4 SERPINC1 SERPINF2
25 tuberculous empyema 10.4 PLG SERPINE1
26 amaurosis fugax 10.4 MTHFR SERPINE1
27 leech infestation 10.3 F2 PLG SERPINC1
28 purpura fulminans 10.3 F2 SERPINC1 SERPINF2
29 femoral neuropathy 10.3 F2 PLG
30 anterior spinal artery syndrome 10.3 F2 PLG SERPINC1
31 lateral sinus thrombosis 10.3 MTHFR PDGFB
32 subendocardial myocardial infarction 10.3 F2 SERPINC1 SERPINE1
33 cerebral sinovenous thrombosis 10.3 APOH F2
34 eclampsia 10.3 F2 MTHFR SERPINC1
35 acute cor pulmonale 10.3 PLG SERPINE1 SERPINF2
36 acute pulmonary heart disease 10.3 PLG SERPINE1 SERPINF2
37 blood protein disease 10.3 F2 MTHFR SERPINC1
38 hepatic veno-occlusive disease 10.3 PLG SERPINC1 SERPINE1
39 hepatitis 10.3
40 endocarditis 10.3 APOH F2 SERPINC1
41 nonarteritic anterior ischemic optic neuropathy 10.3 F2 MTHFR SERPINC1
42 cryptogenic cirrhosis 10.3 F2 MTHFR SERPINE1
43 cerebral arteritis 10.3 F8 PLG
44 varicose veins 10.3 F2 MTHFR SERPINC1
45 prothrombin deficiency, congenital 10.3 APOH F2 SERPINC1
46 purpura 10.2 APOH F2 SERPINC1
47 peripheral vertigo 10.2 APOH F2 SERPINC1
48 intestinal impaction 10.2 F2 PLG SERPINC1 SERPINF2
49 alpha-2-plasmin inhibitor deficiency 10.2 F2 PLG SERPINC1 SERPINF2
50 intracranial embolism 10.2 F2 PLG SERPINC1 SERPINF2

Graphical network of the top 20 diseases related to Livedoid Vasculitis:



Diseases related to Livedoid Vasculitis

Symptoms & Phenotypes for Livedoid Vasculitis

GenomeRNAi Phenotypes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

27 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.81 ADA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.81 ADA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.81 ADA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.81 ADA2 CCNA2 MTHFR PRTN3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.81 PRTN3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.81 PRTN3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.81 ADA2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.81 ADA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.81 ADA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.81 ADA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.81 MTHFR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.81 CCNA2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.81 CCNA2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.81 PRTN3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.81 MTHFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.81 ADA2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.81 ADA2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.81 ADA2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.81 MTHFR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.81 MTHFR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.81 MTHFR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.81 MTHFR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.81 ADA2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.81 PRTN3
25 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.81 ADA2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.81 ADA2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.81 ADA2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.81 PRTN3

MGI Mouse Phenotypes related to Livedoid Vasculitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 C3 CALCR CASR CCNA2 F2 F8
2 homeostasis/metabolism MP:0005376 9.93 APOH C3 CALCR CASR F2 F8
3 immune system MP:0005387 9.7 C3 CALCR CASR CCNA2 F2 F8
4 mortality/aging MP:0010768 9.4 APOH C3 CALCR CASR CCNA2 F2

Drugs & Therapeutics for Livedoid Vasculitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Correlation of Genetic Polymorphism and Livedo Vasculitis Completed NCT00975871
2 Research of Prognostic Factors Associated With Healing of Venous Leg Ulcers Completed NCT01673412 Not Applicable
3 Characteristic of Drug Users Chronic Wound Not yet recruiting NCT03608384

Search NIH Clinical Center for Livedoid Vasculitis

Genetic Tests for Livedoid Vasculitis

Anatomical Context for Livedoid Vasculitis

MalaCards organs/tissues related to Livedoid Vasculitis:

42
Skin, Endothelial

Publications for Livedoid Vasculitis

Articles related to Livedoid Vasculitis:

(show top 50) (show all 87)
# Title Authors Year
1
Chronic leg ulcerations associated with livedoid vasculopathy successfully treated with rivaroxaban. ( 30767258 )
2019
2
Endovenous Laser Ablation Treatment for Lower Extremity Ulcers Associated With Livedoid Vasculopathy. ( 30882502 )
2019
3
Topical becaplermin gel is an effective adjuvant for long-standing ulcers of livedoid vasculopathy recalcitrant to anticoagulant therapy. ( 30706539 )
2019
4
Systemic lupus erythematosus with refractory ulcerated livedoid vasculopathy: Successful treatment with intravenous immunoglobulin and warfarin. ( 30455888 )
2018
5
Traditional Korean medicine treatment for livedoid vasculopathy: Five case reports. ( 30100128 )
2018
6
Livedoid vasculopathy: a compelling diagnosis. ( 30101138 )
2018
7
Prevention of recurrent ulceration of livedoid vasculopathy with long-term apixaban monotherapy. ( 30156315 )
2018
8
Dermoscopy of early non-ulcerated livedoid vasculopathy. ( 30244265 )
2018
9
Successful Treatment of Livedoid Vasculitis with Primary Antiphospholipid Syndrome by Using Aspirin and Low Dose Warfarin Combination Therapy. ( 26512179 )
2015
10
Direct immunofluorescence findings and thrombophilic factors in livedoid vasculopathy: how do they correlate? ( 23692592 )
2014
11
Treatment of livedoid vasculopathy with alprostadil (PGE-1): case report and review of published literature. ( 22364635 )
2013
12
Rivaroxaban prevents painful cutaneous infarctions in livedoid vasculopathy. ( 23106384 )
2013
13
Livedoid vasculopathy--a vasculitic mimic. ( 23203724 )
2013
14
Livedoid vasculopathy - current aspects of diagnosis and treatment of cutaneous infarction. ( 23437985 )
2013
15
Intravenous immunoglobulins in difficult-to-treat ulcerated livedoid vasculopathy: five cases and a literature review. ( 23488633 )
2013
16
Livedoid vasculopathy successfully treated with hyperbaric oxygen. ( 23508660 )
2013
17
Livedoid vasculopathy - a thrombotic disease. ( 23989066 )
2013
18
Livedoid vasculopathy: an in-depth analysis using a modified Delphi approach. ( 24028907 )
2013
19
Association between peripheral vascular endothelial dysfunction and livedoid vasculopathy. ( 21982058 )
2012
20
Livedoid vasculopathy associated with sickle cell trait: significant improvement on aspirin treatment. ( 22044499 )
2012
21
Livedoid vasculopathy in a patient with lupus anticoagulant and MTHFR mutation: treatment with low-molecular-weight heparin. ( 22592843 )
2012
22
What caused this painful skin erosion? Livedoid vasculopathy. ( 22712143 )
2012
23
Update of management of connective tissue diseases: livedoid vasculopathy. ( 22741937 )
2012
24
Painless Livedoid Vasculopathy in a Patient with G20210A Prothrombin Gene Mutation. ( 22988463 )
2012
25
Livedoid vasculopathy. ( 23259203 )
2012
26
Livedoid vasculopathy: review of pathogenesis, clinical presentation, diagnostic workup, and treatment. ( 23409480 )
2012
27
Livedoid vasculopathy managed with hyperbaric oxygen therapy. ( 24532913 )
2012
28
Ischemic neuropathy associated with livedoid vasculitis. ( 22259622 )
2011
29
The significance of anticardiolipin antibody and immunologic abnormality in livedoid vasculitis. ( 21182497 )
2011
30
Livedoid vasculopathy as a coagulation disorder. ( 21184847 )
2011
31
Livedoid vasculopathy secondary to high levels of lipoprotein(a). ( 21219292 )
2011
32
Severe livedoid vasculopathy associated with antiphosphatidylserine-prothrombin complex antibody successfully treated with warfarin. ( 21576587 )
2011
33
Livedoid vasculopathy; favorable clinical response with low dose warfarin. ( 21914587 )
2011
34
Successful long-term use of intravenous immunoglobulin to treat livedoid vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity. ( 22006147 )
2011
35
Livedoid vasculopathy: an intringuing cutaneous disease. ( 22147037 )
2011
36
Livedoid vasculopathy: fast involution after anticoagulant and hyperbaric oxygen therapy. ( 26760818 )
2011
37
Livedoid vasculopathy: thrombotic or inflammatory disease? ( 19874344 )
2010
38
Case of livedoid vasculopathy with extensive dermal capillary thrombi. ( 20175829 )
2010
39
Case of livedoid vasculopathy with peripheral neuropathy successfully treated with low-dose warfarin. ( 20175830 )
2010
40
Livedoid vasculopathy in a woman with multiple myeloma. ( 20622720 )
2010
41
Livedoid vasculopathy in a pediatric patient with elevated lipoprotein(a) levels: prompt response to continuous low-molecular-weight heparin. ( 20713839 )
2010
42
Livedoid vasculopathy with underlying subcutaneous necrotizing venulitis in an asymptomatic hepatitis B virus carrier: is livedoid vasculopathy a true nonvasculitic disorder? ( 19384073 )
2009
43
Homeopathic treatment in resistant livedoid vasculopathy: case report. ( 19647211 )
2009
44
Livedoid vasculopathy and pregnancy. ( 19647821 )
2009
45
Ulcerations caused by livedoid vasculopathy associated with a prothrombotic state: Response to warfarin. ( 18280355 )
2008
46
A case of widespread livedoid vasculopathy with pain but no systemic symptoms. ( 18480943 )
2008
47
Successful use of rituximab in a patient with recalcitrant livedoid vasculopathy. ( 18556452 )
2008
48
Therapeutic effect of lipoprostaglandin E1 on livedoid vasculitis associated with essential cryoglobulinaemia. ( 17725674 )
2007
49
Heterozygous prothrombin gene mutation associated with livedoid vasculopathy. ( 17535202 )
2007
50
Livedoid vasculopathy. The role of hyperhomocysteinemia and its simple therapeutic consequences. ( 16581568 )
2006

Variations for Livedoid Vasculitis

Expression for Livedoid Vasculitis

Search GEO for disease gene expression data for Livedoid Vasculitis.

Pathways for Livedoid Vasculitis

GO Terms for Livedoid Vasculitis

Cellular components related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 ADA2 APOH C3 F2 F8 LPA
2 cell surface GO:0009986 9.85 APOH CASR PDGFB PLG SERPINF2
3 endoplasmic reticulum lumen GO:0005788 9.77 C3 F2 F8 PDGFB SERPINC1
4 blood microparticle GO:0072562 9.72 C3 F2 PLG SERPINC1 SERPINF2
5 azurophil granule lumen GO:0035578 9.58 ADA2 C3 PRTN3
6 platelet alpha granule lumen GO:0031093 9.35 F8 PDGFB PLG SERPINE1 SERPINF2
7 collagen-containing extracellular matrix GO:0062023 9.17 APOH PDGFB PLG PRTN3 SERPINC1 SERPINE1
8 extracellular exosome GO:0070062 10.03 APOH C3 F2 PLG PRTN3 SERPINC1
9 extracellular space GO:0005615 10 ADA2 APOH C3 F2 F8 PDGFB

Biological processes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.97 C3 F2 LPA PLG PRTN3
2 positive regulation of cell proliferation GO:0008284 9.93 CASR CCNA2 F2 PDGFB PRTN3
3 cellular protein metabolic process GO:0044267 9.88 ADA2 C3 F2 PLG SERPINC1
4 blood coagulation GO:0007596 9.83 F2 F8 PLG PRTN3 SERPINC1
5 negative regulation of peptidase activity GO:0010466 9.74 SERPINC1 SERPINE1 SERPINF2
6 acute-phase response GO:0006953 9.67 F2 F8 SERPINF2
7 negative regulation of endopeptidase activity GO:0010951 9.65 C3 LPA SERPINC1 SERPINE1 SERPINF2
8 blood coagulation, intrinsic pathway GO:0007597 9.63 APOH F2 F8
9 hemostasis GO:0007599 9.62 F2 F8 PLG SERPINC1
10 positive regulation of collagen biosynthetic process GO:0032967 9.58 F2 SERPINF2
11 positive regulation of blood coagulation GO:0030194 9.58 APOH F2 SERPINE1
12 positive regulation of calcium ion import GO:0090280 9.56 CASR PDGFB
13 negative regulation of blood coagulation GO:0030195 9.55 APOH SERPINE1
14 regulation of blood coagulation GO:0030193 9.54 APOH F2 SERPINC1
15 negative regulation of platelet activation GO:0010544 9.52 F2 PDGFB
16 negative regulation of plasminogen activation GO:0010757 9.51 SERPINE1 SERPINF2
17 fibrinolysis GO:0042730 9.46 F2 PLG SERPINE1 SERPINF2
18 platelet degranulation GO:0002576 9.43 APOH F8 PDGFB PLG SERPINE1 SERPINF2
19 negative regulation of fibrinolysis GO:0051918 9.02 APOH F2 PLG SERPINE1 SERPINF2

Molecular functions related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 C3 F2 PLG PRTN3 SERPINE1
2 peptidase inhibitor activity GO:0030414 9.63 SERPINC1 SERPINE1 SERPINF2
3 protease binding GO:0002020 9.58 SERPINC1 SERPINE1 SERPINF2
4 serine-type peptidase activity GO:0008236 9.56 F2 LPA PLG PRTN3
5 serine-type endopeptidase inhibitor activity GO:0004867 9.54 SERPINC1 SERPINE1 SERPINF2
6 apolipoprotein binding GO:0034185 9.43 LPA PLG
7 serine-type endopeptidase activity GO:0004252 9.35 C3 F2 LPA PLG PRTN3
8 endopeptidase inhibitor activity GO:0004866 9.33 C3 LPA SERPINF2
9 heparin binding GO:0008201 9.02 ADA2 APOH F2 LPA SERPINC1

Sources for Livedoid Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
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75 UMLS via Orphanet
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