MCID: LVD003
MIFTS: 39

Livedoid Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Skin diseases

Aliases & Classifications for Livedoid Vasculitis

MalaCards integrated aliases for Livedoid Vasculitis:

Name: Livedoid Vasculitis 12 53 15 33
Livedoid Vasculopathy 12 53 59
Livedo Reticularis with Summer Ulcerations 53 59
Livedo Reticularis with Winter Ulcerations 53
Segmental Hyalinizing Vasculopathy 53
Segmental Hyalinizing Vasculitis 59
Milian Atrophie Blanche 59
Livedo Vasculitis 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0040099
ICD9CM 35 709.1
ICD10 33 L95.0
Orphanet 59 ORPHA542643

Summaries for Livedoid Vasculitis

NIH Rare Diseases : 53 Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

MalaCards based summary : Livedoid Vasculitis, also known as livedoid vasculopathy, is related to purpura and protein c deficiency. An important gene associated with Livedoid Vasculitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include skin and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A vasculitis with purpuric ulcers.

Wikipedia : 75 Livedoid vasculopathy is a chronic cutaneous disease seen predominantly in young to middle-aged women.... more...

Related Diseases for Livedoid Vasculitis

Diseases related to Livedoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 purpura 31.1 SERPINC1 F2 APOH
2 protein c deficiency 31.1 SERPINC1 MTHFR F2
3 sticky platelet syndrome 31.0 SERPINE1 SERPINC1
4 ischemic neuropathy 30.8 MTHFR F2
5 homocysteinemia 30.7 SERPINC1 MTHFR F2
6 antiphospholipid syndrome 30.5 SERPINC1 MTHFR F2 APOH
7 polyarteritis nodosa 30.5 PRTN3 APOH ADA2
8 disseminated intravascular coagulation 30.5 SERPINF2 SERPINE1 SERPINC1 F2
9 branch retinal artery occlusion 30.3 SERPINC1 MTHFR F2 APOH
10 protein s deficiency 30.3 SERPINC1 MTHFR F2 APOH
11 antithrombin iii deficiency 30.2 SERPINC1 MTHFR F2 APOH
12 sneddon syndrome 30.1 SERPINC1 F2 APOH ADA2
13 thrombophilia 29.8 SERPINE1 SERPINC1 MTHFR F8 F2 APOH
14 thrombophilia due to thrombin defect 29.4 SERPINE1 SERPINC1 MTHFR F8 F2 APOH
15 intracranial thrombosis 29.4 SERPINC1 PLG MTHFR F8 APOH
16 retinal artery occlusion 29.2 SERPINE1 SERPINC1 MTHFR F8 F2 APOH
17 thrombosis 29.2 SERPINE1 SERPINC1 MTHFR F8 F2 APOH
18 thrombophilia due to activated protein c resistance 28.7 SERPINF2 SERPINE1 SERPINC1 PLG MTHFR F8
19 stroke, ischemic 28.7 SERPINF2 SERPINE1 SERPINC1 PLG MTHFR LPA
20 vasculitis 10.8
21 fibrinolytic defect 10.7 SERPINE1 SERPINC1
22 cerebral falx meningioma 10.6 PLG F2
23 platelet aggregation, spontaneous 10.6 SERPINF2 SERPINC1
24 sagittal sinus thrombosis 10.6 SERPINC1 F2
25 plasminogen activator inhibitor-1 deficiency 10.6 SERPINF2 SERPINE1
26 argentine hemorrhagic fever 10.6 SERPINE1 SERPINC1
27 aspirin allergy 10.6 SERPINE1 SERPINC1
28 cold urticaria 10.6 SERPINF2 SERPINC1
29 mesenteric vascular occlusion 10.6 MTHFR F2
30 amaurosis fugax 10.6 SERPINE1 MTHFR
31 neonatal stroke 10.6 SERPINE1 MTHFR
32 tuberculous empyema 10.5 SERPINE1 PLG
33 femoral neuropathy 10.5 PLG F2
34 purpura fulminans 10.5 SERPINF2 SERPINC1 F2
35 leech infestation 10.5 SERPINC1 PLG F2
36 anterior spinal artery syndrome 10.5 SERPINC1 PLG F2
37 lateral sinus thrombosis 10.5 PDGFB MTHFR
38 subendocardial myocardial infarction 10.5 SERPINE1 SERPINC1 F2
39 cerebral sinovenous thrombosis 10.5 F2 APOH
40 eclampsia 10.5 SERPINC1 MTHFR F2
41 anterior cranial fossa meningioma 10.5 PLG F2
42 acute poststreptococcal glomerulonephritis 10.5 SERPINF2 PLG
43 skin disease 10.4
44 blood protein disease 10.4 SERPINC1 MTHFR F2
45 acute cor pulmonale 10.4 SERPINF2 SERPINE1 PLG
46 acute pulmonary heart disease 10.4 SERPINF2 SERPINE1 PLG
47 hepatic veno-occlusive disease 10.4 SERPINE1 SERPINC1 PLG
48 nonarteritic anterior ischemic optic neuropathy 10.4 SERPINC1 MTHFR F2
49 cryptogenic cirrhosis 10.4 SERPINE1 MTHFR F2
50 varicose veins 10.4 SERPINC1 MTHFR F2

Graphical network of the top 20 diseases related to Livedoid Vasculitis:



Diseases related to Livedoid Vasculitis

Symptoms & Phenotypes for Livedoid Vasculitis

MGI Mouse Phenotypes related to Livedoid Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 C3 CALCR CCNA2 F2 F8 PDGFB
2 homeostasis/metabolism MP:0005376 10 APOH C3 CALCR F2 F8 MTHFR
3 immune system MP:0005387 9.85 C3 CALCR CCNA2 F2 F8 PDGFB
4 liver/biliary system MP:0005370 9.43 C3 MTHFR PDGFB PLG SERPINC1 SERPINE1
5 mortality/aging MP:0010768 9.36 APOH C3 CALCR CCNA2 F2 F8

Drugs & Therapeutics for Livedoid Vasculitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Correlation of Genetic Polymorphism and Livedo Vasculitis Completed NCT00975871

Search NIH Clinical Center for Livedoid Vasculitis

Genetic Tests for Livedoid Vasculitis

Anatomical Context for Livedoid Vasculitis

MalaCards organs/tissues related to Livedoid Vasculitis:

41
Skin, Endothelial

Publications for Livedoid Vasculitis

Articles related to Livedoid Vasculitis:

(show top 50) (show all 212)
# Title Authors PMID Year
1
Topical becaplermin gel is an effective adjuvant for long-standing ulcers of livedoid vasculopathy recalcitrant to anticoagulant therapy. 38
30706539 2019
2
Retiform non-blanchable purpuric plaques in a patient with systemic lupus erythematosus. 38
31126212 2019
3
Livedoid vasculopathy: does hyperhomocysteinaemia play an aetiological role? 38
31389788 2019
4
Characteristics, risk factors and treatment reality in livedoid vasculopathy - a multicentre analysis. 38
31009111 2019
5
Livedoid vasculopathy presenting with leg ulcers. 38
31220328 2019
6
Prevention of recurrent ulceration of livedoid vasculopathy with long-term apixaban monotherapy. 38
30156315 2019
7
Endovenous Laser Ablation Treatment for Lower Extremity Ulcers Associated With Livedoid Vasculopathy. 38
30882502 2019
8
Chronic leg ulcerations associated with livedoid vasculopathy successfully treated with rivaroxaban. 38
30767258 2019
9
Systemic lupus erythematosus with refractory ulcerated livedoid vasculopathy: Successful treatment with intravenous immunoglobulin and warfarin. 38
30455888 2018
10
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options. 38
29738044 2018
11
Traditional Korean medicine treatment for livedoid vasculopathy: Five case reports. 38
30100128 2018
12
Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease. 38
29533274 2018
13
Dermoscopy of early non-ulcerated livedoid vasculopathy. 38
30244265 2018
14
Livedoid vasculopathy: a compelling diagnosis. 38
30101138 2018
15
Systemic therapies for leg ulcers. 38
29989361 2018
16
The management of livedoid vasculopathy focused on direct oral anticoagulants (DOACs): four case reports successfully treated with rivaroxaban. 38
29663354 2018
17
Three cases of lymphocytic thrombophilic arteritis presenting with an annular eruption. 38
28752544 2018
18
Treatment of Livedoid Vasculopathy With Rivaroxaban: A Potential Use of New Oral Anticoagulants for Dermatologists. 38
29074145 2018
19
Livedoid vasculopathy in a patient with bullous pemphigoid and primary Sjögren's syndrome. 38
29526676 2018
20
Ulcerative livedoid vasculopathy responding to clopidogrel. 38
29892667 2018
21
Treatment for Livedoid Vasculopathy: A Systematic Review. 38
29141075 2018
22
Systemic Lupus Erythematosus Presenting as Livedoid Vasculopathy over the Forearms. 38
29911533 2018
23
Vasculopathies, cutaneous necrosis and emergency in dermatology. 38
28845953 2017
24
Prevention of livedoid vasculopathy recurrence by prolonged administration of rivaroxaban. 38
28609556 2017
25
Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy. 38
28901563 2017
26
Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis. 38
28252815 2017
27
Livedoid Vasculopathy. 38
28511282 2017
28
Occlusive Nonvasculitic Vasculopathy. 38
27759698 2017
29
Use of Low-dose Oral Warfarin in Three Cases of Livedoid Vasculopathy. 38
28979014 2017
30
Efficacy of new low-dose oral anticoagulants in recalcitrant livedoid vasculopathy. 38
28739563 2017
31
Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions. 38
28186689 2017
32
[Livedoid vasculopathy secondary to coeliac disease]. 38
28283193 2017
33
Dabigatran in the management of livedoid vasculopathy. 38
28052437 2017
34
Dermoscopic features of livedoid vasculopathy. 38
28296736 2017
35
Vasculitic and autoimmune wounds. 38
28214498 2017
36
Fast Cicatrization of Extensive Livedoid Vasculopathy Ulcers under Treatment with Sildenafil. 38
28223767 2017
37
Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. 38
27774697 2017
38
Rapid remission of severe pain from livedoid vasculopathy by apixaban. 38
27166520 2017
39
Treatment application of rivaroxaban in Chinese patients with livedoid vasculopathy. 38
28360530 2017
40
[What's new in clinical dermatology?] 38
29429503 2016
41
Anticoagulants in dermatology. 38
27320765 2016
42
Livedoid vasculopathy. 38
27914604 2016
43
Recalcitrant Livedoid Vasculopathy Associated with Hyperhomocysteinaemia Responding to Folic Acid and Vitamins B6/B12 Supplementation. 38
27001413 2016
44
Livedoid vasculopathy: A review of pathogenesis and principles of management. 38
27297279 2016
45
Livedoid Vasculopathy Associated with HIV Infection in Two Patients: A Causal Relationship? 38
26778817 2016
46
Livedoid vasculopathy - a challenging disease. 38
27155327 2016
47
Case series of recalcitrant livedoid vasculopathy treated with rivaroxaban. 38
26993107 2016
48
Cilostazol: A novel agent in recalcitrant livedoid vasculopathy. 38
26345653 2016
49
New hope for patients with livedoid vasculopathy. 38
26853641 2016
50
Livedoid vasculopathy. 38
26952873 2016

Variations for Livedoid Vasculitis

Expression for Livedoid Vasculitis

Search GEO for disease gene expression data for Livedoid Vasculitis.

GO Terms for Livedoid Vasculitis

Cellular components related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.77 SERPINC1 PDGFB F8 F2 C3
2 extracellular region GO:0005576 9.73 SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG PDGFB
3 blood microparticle GO:0072562 9.72 SERPINF2 SERPINC1 PLG F2 C3
4 azurophil granule lumen GO:0035578 9.61 PRTN3 C3 ADA2
5 platelet alpha granule lumen GO:0031093 9.55 SERPINF2 SERPINE1 PLG PDGFB F8
6 collagen-containing extracellular matrix GO:0062023 9.17 SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG PDGFB
7 extracellular exosome GO:0070062 10.01 SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG F2
8 extracellular space GO:0005615 10 SERPINF2 SERPINE1 SERPINC1 PRTN3 PLG PDGFB

Biological processes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.88 SERPINC1 PLG F2 C3 ADA2
2 proteolysis GO:0006508 9.86 PRTN3 PLG LPA F2
3 blood coagulation GO:0007596 9.83 SERPINC1 PRTN3 PLG F8 F2
4 negative regulation of peptidase activity GO:0010466 9.72 SERPINF2 SERPINE1 SERPINC1
5 acute-phase response GO:0006953 9.67 SERPINF2 F8 F2
6 negative regulation of endopeptidase activity GO:0010951 9.65 SERPINF2 SERPINE1 SERPINC1 LPA C3
7 blood coagulation, intrinsic pathway GO:0007597 9.63 F8 F2 APOH
8 hemostasis GO:0007599 9.62 SERPINC1 PLG F8 F2
9 regulation of blood coagulation GO:0030193 9.58 SERPINC1 F2 APOH
10 positive regulation of collagen biosynthetic process GO:0032967 9.57 SERPINF2 F2
11 negative regulation of blood coagulation GO:0030195 9.54 SERPINE1 APOH
12 positive regulation of blood coagulation GO:0030194 9.54 SERPINE1 F2 APOH
13 negative regulation of platelet activation GO:0010544 9.52 PDGFB F2
14 negative regulation of plasminogen activation GO:0010757 9.51 SERPINF2 SERPINE1
15 fibrinolysis GO:0042730 9.46 SERPINF2 SERPINE1 PLG F2
16 platelet degranulation GO:0002576 9.43 SERPINF2 SERPINE1 PLG PDGFB F8 APOH
17 negative regulation of fibrinolysis GO:0051918 9.02 SERPINF2 SERPINE1 PLG F2 APOH

Molecular functions related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 SERPINE1 PRTN3 PLG F2 C3
2 peptidase inhibitor activity GO:0030414 9.63 SERPINF2 SERPINE1 SERPINC1
3 protease binding GO:0002020 9.58 SERPINF2 SERPINE1 SERPINC1
4 serine-type peptidase activity GO:0008236 9.56 PRTN3 PLG LPA F2
5 serine-type endopeptidase inhibitor activity GO:0004867 9.54 SERPINF2 SERPINE1 SERPINC1
6 apolipoprotein binding GO:0034185 9.43 PLG LPA
7 endopeptidase inhibitor activity GO:0004866 9.33 SERPINF2 LPA C3
8 serine-type endopeptidase activity GO:0004252 9.26 PRTN3 PLG LPA F2
9 heparin binding GO:0008201 9.02 SERPINC1 LPA F2 APOH ADA2

Sources for Livedoid Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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