MCID: LVD003
MIFTS: 46

Livedoid Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Skin diseases

Aliases & Classifications for Livedoid Vasculitis

MalaCards integrated aliases for Livedoid Vasculitis:

Name: Livedoid Vasculitis 12 54 15
Livedoid Vasculopathy 12 54
Livedo Reticularis with Summer Ulcerations 54
Livedo Reticularis with Winter Ulcerations 54
Segmental Hyalinizing Vasculopathy 54
Livedo Vasculitis 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0040099
ICD9CM 36 709.1
ICD10 34 L95.0

Summaries for Livedoid Vasculitis

NIH Rare Diseases : 54 Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

MalaCards based summary : Livedoid Vasculitis, also known as livedoid vasculopathy, is related to protein c deficiency and ischemic neuropathy. An important gene associated with Livedoid Vasculitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Cathartics and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A vasculitis with purpuric ulcers.

Wikipedia : 77 Livedoid vasculopathy is a chronic cutaneous disease seen predominantly in young to middle-aged women.... more...

Related Diseases for Livedoid Vasculitis

Diseases related to Livedoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 protein c deficiency 30.5 F2 MTHFR SERPINC1
2 ischemic neuropathy 30.5 F2 MTHFR
3 homocysteinemia 30.4 F2 MTHFR SERPINC1
4 antiphospholipid syndrome 30.4 APOH F2 MTHFR SERPINC1
5 branch retinal artery occlusion 30.2 APOH F2 MTHFR SERPINC1
6 protein s deficiency 30.2 APOH F2 MTHFR SERPINC1
7 antithrombin iii deficiency 30.2 APOH F2 MTHFR SERPINC1
8 sneddon syndrome 30.1 ADA2 APOH F2 SERPINC1
9 thrombophilia 29.9 APOH F2 F8 MTHFR SERPINC1 SERPINE1
10 intracranial thrombosis 29.7 APOH F8 MTHFR PLG SERPINC1
11 retinal artery occlusion 29.6 APOH F2 F8 MTHFR SERPINC1 SERPINE1
12 thrombosis 29.6 APOH F2 F8 MTHFR SERPINC1 SERPINE1
13 vasculitis 10.7
14 fibrinolytic defect 10.4 SERPINC1 SERPINE1
15 cerebral falx meningioma 10.4 F2 PLG
16 plasminogen activator inhibitor-1 deficiency 10.4 SERPINE1 SERPINF2
17 platelet aggregation, spontaneous 10.4 SERPINC1 SERPINF2
18 aspirin allergy 10.4 SERPINC1 SERPINE1
19 argentine hemorrhagic fever 10.4 SERPINC1 SERPINE1
20 sticky platelet syndrome 10.4 SERPINC1 SERPINE1
21 sagittal sinus thrombosis 10.4 F2 SERPINC1
22 inferior vena cava interruption 10.4 MTHFR SERPINE1
23 mesenteric vascular occlusion 10.4 F2 MTHFR
24 neonatal stroke 10.4 MTHFR SERPINE1
25 cold urticaria 10.4 SERPINC1 SERPINF2
26 amaurosis fugax 10.4 MTHFR SERPINE1
27 tuberculous empyema 10.3 PLG SERPINE1
28 purpura fulminans 10.3 F2 SERPINC1 SERPINF2
29 leech infestation 10.3 F2 PLG SERPINC1
30 femoral neuropathy 10.3 F2 PLG
31 lateral sinus thrombosis 10.3 MTHFR PDGFB
32 anterior spinal artery syndrome 10.3 F2 PLG SERPINC1
33 subendocardial myocardial infarction 10.3 F2 SERPINC1 SERPINE1
34 cerebral sinovenous thrombosis 10.3 APOH F2
35 eclampsia 10.3 F2 MTHFR SERPINC1
36 blood protein disease 10.3 F2 MTHFR SERPINC1
37 acute cor pulmonale 10.3 PLG SERPINE1 SERPINF2
38 acute pulmonary heart disease 10.3 PLG SERPINE1 SERPINF2
39 hepatitis 10.3
40 hepatic veno-occlusive disease 10.3 PLG SERPINC1 SERPINE1
41 endocarditis 10.3 APOH F2 SERPINC1
42 nonarteritic anterior ischemic optic neuropathy 10.3 F2 MTHFR SERPINC1
43 cryptogenic cirrhosis 10.3 F2 MTHFR SERPINE1
44 varicose veins 10.3 F2 MTHFR SERPINC1
45 cerebral arteritis 10.3 F8 PLG
46 prothrombin deficiency, congenital 10.3 APOH F2 SERPINC1
47 purpura 10.3 APOH F2 SERPINC1
48 peripheral vertigo 10.2 APOH F2 SERPINC1
49 papilledema 10.2 APOH F2
50 intestinal impaction 10.2 F2 PLG SERPINC1 SERPINF2

Graphical network of the top 20 diseases related to Livedoid Vasculitis:



Diseases related to Livedoid Vasculitis

Symptoms & Phenotypes for Livedoid Vasculitis

GenomeRNAi Phenotypes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

27 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.8 ADA2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.8 ADA2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.8 ADA2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.8 ADA2 CCNA2 MTHFR PRTN3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.8 PRTN3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.8 PRTN3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.8 ADA2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.8 ADA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.8 ADA2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.8 ADA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.8 MTHFR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.8 CCNA2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.8 CCNA2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.8 PRTN3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.8 MTHFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.8 ADA2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.8 ADA2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.8 ADA2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.8 MTHFR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.8 MTHFR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.8 MTHFR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.8 ADA2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.8 PRTN3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.8 ADA2
25 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.8 ADA2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-97 9.8 ADA2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.8 PRTN3

MGI Mouse Phenotypes related to Livedoid Vasculitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 C3 CALCR CASR CCNA2 F2 F8
2 homeostasis/metabolism MP:0005376 9.93 APOH C3 CALCR CASR F2 F8
3 immune system MP:0005387 9.7 C3 CALCR CASR CCNA2 F2 F8
4 mortality/aging MP:0010768 9.4 APOH C3 CALCR CASR CCNA2 F2

Drugs & Therapeutics for Livedoid Vasculitis

Drugs for Livedoid Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cathartics Not Applicable
2 Gastrointestinal Agents Not Applicable
3 Laxatives Not Applicable
4 Carboxymethylcellulose Sodium Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Correlation of Genetic Polymorphism and Livedo Vasculitis Completed NCT00975871
2 Characteristic of Drug Users Chronic Wound Completed NCT03608384
3 Research of Prognostic Factors Associated With Healing of Venous Leg Ulcers Completed NCT01673412 Not Applicable
4 A Comparative Evaluation of a MPS Dressing and a CMC Dressing on Subjects With Lower Extremity Venous Ulcers Not yet recruiting NCT03903692 Not Applicable

Search NIH Clinical Center for Livedoid Vasculitis

Genetic Tests for Livedoid Vasculitis

Anatomical Context for Livedoid Vasculitis

MalaCards organs/tissues related to Livedoid Vasculitis:

42
Skin, Heart, Endothelial, Kidney, Liver, Breast, Spinal Cord

Publications for Livedoid Vasculitis

Articles related to Livedoid Vasculitis:

(show top 50) (show all 154)
# Title Authors Year
1
Prevention of recurrent ulceration of livedoid vasculopathy with long-term apixaban monotherapy. ( 30156315 )
2019
2
Topical becaplermin gel is an effective adjuvant for long-standing ulcers of livedoid vasculopathy recalcitrant to anticoagulant therapy. ( 30706539 )
2019
3
Chronic leg ulcerations associated with livedoid vasculopathy successfully treated with rivaroxaban. ( 30767258 )
2019
4
Endovenous Laser Ablation Treatment for Lower Extremity Ulcers Associated With Livedoid Vasculopathy. ( 30882502 )
2019
5
Characteristics, risk factors, and treatment reality in livedoid vasculopathy - a multi-centre analysis. ( 31009111 )
2019
6
Livedoid vasculopathy in a patient with bullous pemphigoid and primary Sjögren's syndrome. ( 29526676 )
2018
7
Systemic lupus erythematosus with refractory ulcerated livedoid vasculopathy: Successful treatment with intravenous immunoglobulin and warfarin. ( 30455888 )
2018
8
Systemic Lupus Erythematosus Presenting as Livedoid Vasculopathy over the Forearms. ( 29911533 )
2018
9
Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease. ( 29533274 )
2018
10
Treatment of Livedoid Vasculopathy With Rivaroxaban: A Potential Use of New Oral Anticoagulants for Dermatologists. ( 29074145 )
2018
11
Treatment for Livedoid Vasculopathy: A Systematic Review. ( 29141075 )
2018
12
The management of livedoid vasculopathy focused on direct oral anticoagulants (DOACs): four case reports successfully treated with rivaroxaban. ( 29663354 )
2018
13
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options. ( 29738044 )
2018
14
Ulcerative livedoid vasculopathy responding to clopidogrel. ( 29892667 )
2018
15
Traditional Korean medicine treatment for livedoid vasculopathy: Five case reports. ( 30100128 )
2018
16
Livedoid vasculopathy: a compelling diagnosis. ( 30101138 )
2018
17
Dermoscopy of early non-ulcerated livedoid vasculopathy. ( 30244265 )
2018
18
Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis. ( 28252815 )
2017
19
Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. ( 27774697 )
2017
20
Rapid remission of severe pain from livedoid vasculopathy by apixaban. ( 27166520 )
2017
21
Dabigatran in the management of livedoid vasculopathy. ( 28052437 )
2017
22
Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions. ( 28186689 )
2017
23
Fast Cicatrization of Extensive Livedoid Vasculopathy Ulcers under Treatment with Sildenafil. ( 28223767 )
2017
24
Dermoscopic features of livedoid vasculopathy. ( 28296736 )
2017
25
Treatment application of rivaroxaban in Chinese patients with livedoid vasculopathy. ( 28360530 )
2017
26
Livedoid Vasculopathy. ( 28511282 )
2017
27
Prevention of livedoid vasculopathy recurrence by prolonged administration of rivaroxaban. ( 28609556 )
2017
28
Efficacy of new low-dose oral anticoagulants in recalcitrant livedoid vasculopathy. ( 28739563 )
2017
29
Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy. ( 28901563 )
2017
30
Use of Low-dose Oral Warfarin in Three Cases of Livedoid Vasculopathy. ( 28979014 )
2017
31
Cilostazol: A novel agent in recalcitrant livedoid vasculopathy. ( 26345653 )
2016
32
Livedoid Vasculopathy Associated with HIV Infection in Two Patients: A Causal Relationship? ( 26778817 )
2016
33
New hope for patients with livedoid vasculopathy. ( 26853641 )
2016
34
Anticoagulation with rivaroxaban for livedoid vasculopathy (RILIVA): a multicentre, single-arm, open-label, phase 2a, proof-of-concept trial. ( 26853646 )
2016
35
Livedoid vasculopathy. ( 26952873 )
2016
36
Case series of recalcitrant livedoid vasculopathy treated with rivaroxaban. ( 26993107 )
2016
37
Recalcitrant Livedoid Vasculopathy Associated with Hyperhomocysteinaemia Responding to Folic Acid and Vitamins B6/B12 Supplementation. ( 27001413 )
2016
38
Livedoid vasculopathy - a challenging disease. ( 27155327 )
2016
39
Livedoid vasculopathy: A review of pathogenesis and principles of management. ( 27297279 )
2016
40
Livedoid vasculopathy. ( 27914604 )
2016
41
Successful Treatment of Livedoid Vasculitis with Primary Antiphospholipid Syndrome by Using Aspirin and Low Dose Warfarin Combination Therapy. ( 26512179 )
2015
42
Mononeuritis multiplex associated with primary livedoid vasculopathy: neuropathological evidence of ischemic nerve damage. ( 25798525 )
2015
43
Therapeutic effect of autologous platelet-rich plasma (PRP) on recalcitrant cutaneous ulcers in livedoid vasculopathy. ( 27051763 )
2015
44
Livedoid Vasculopathy with Hyperhomocysteinemia Responding to Hyperbaric Oxygen Therapy. ( 26538741 )
2015
45
Sensory ganglionopathy with livedoid vasculopathy controlled by immunotherapy. ( 25196820 )
2015
46
Response of livedoid vasculopathy to rivaroxaban. ( 25255997 )
2015
47
Livedoid vasculopathy and high levels of lipoprotein (a): response to danazol. ( 25824252 )
2015
48
Pulsed intravenous immunoglobulin therapy in refractory ulcerated livedoid vasculopathy: seven cases and a literature review. ( 25845419 )
2015
49
Expanding the spectrum of livedoid vasculopathy: peculiar neuromuscular manifestations. ( 25871345 )
2015
50
Lipoprotein(a) and livedoid vasculopathy: A new thrombophilic factor? ( 26328479 )
2015

Variations for Livedoid Vasculitis

Expression for Livedoid Vasculitis

Search GEO for disease gene expression data for Livedoid Vasculitis.

Pathways for Livedoid Vasculitis

GO Terms for Livedoid Vasculitis

Cellular components related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 ADA2 APOH C3 F2 F8 LPA
2 cell surface GO:0009986 9.85 APOH CASR PDGFB PLG SERPINF2
3 endoplasmic reticulum lumen GO:0005788 9.77 C3 F2 F8 PDGFB SERPINC1
4 blood microparticle GO:0072562 9.72 C3 F2 PLG SERPINC1 SERPINF2
5 azurophil granule lumen GO:0035578 9.58 ADA2 C3 PRTN3
6 platelet alpha granule lumen GO:0031093 9.35 F8 PDGFB PLG SERPINE1 SERPINF2
7 collagen-containing extracellular matrix GO:0062023 9.17 APOH PDGFB PLG PRTN3 SERPINC1 SERPINE1
8 extracellular exosome GO:0070062 10.03 APOH C3 F2 PLG PRTN3 SERPINC1
9 extracellular space GO:0005615 10 ADA2 APOH C3 F2 F8 PDGFB

Biological processes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 CASR CCNA2 F2 PDGFB PRTN3
2 proteolysis GO:0006508 9.88 F2 LPA PLG PRTN3
3 cellular protein metabolic process GO:0044267 9.88 ADA2 C3 F2 PLG SERPINC1
4 blood coagulation GO:0007596 9.83 F2 F8 PLG PRTN3 SERPINC1
5 negative regulation of peptidase activity GO:0010466 9.74 SERPINC1 SERPINE1 SERPINF2
6 acute-phase response GO:0006953 9.67 F2 F8 SERPINF2
7 negative regulation of endopeptidase activity GO:0010951 9.65 C3 LPA SERPINC1 SERPINE1 SERPINF2
8 blood coagulation, intrinsic pathway GO:0007597 9.63 APOH F2 F8
9 hemostasis GO:0007599 9.62 F2 F8 PLG SERPINC1
10 positive regulation of collagen biosynthetic process GO:0032967 9.58 F2 SERPINF2
11 positive regulation of blood coagulation GO:0030194 9.58 APOH F2 SERPINE1
12 positive regulation of calcium ion import GO:0090280 9.56 CASR PDGFB
13 negative regulation of blood coagulation GO:0030195 9.55 APOH SERPINE1
14 regulation of blood coagulation GO:0030193 9.54 APOH F2 SERPINC1
15 negative regulation of platelet activation GO:0010544 9.52 F2 PDGFB
16 negative regulation of plasminogen activation GO:0010757 9.51 SERPINE1 SERPINF2
17 fibrinolysis GO:0042730 9.46 F2 PLG SERPINE1 SERPINF2
18 platelet degranulation GO:0002576 9.43 APOH F8 PDGFB PLG SERPINE1 SERPINF2
19 negative regulation of fibrinolysis GO:0051918 9.02 APOH F2 PLG SERPINE1 SERPINF2

Molecular functions related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 C3 F2 PLG PRTN3 SERPINE1
2 peptidase inhibitor activity GO:0030414 9.63 SERPINC1 SERPINE1 SERPINF2
3 protease binding GO:0002020 9.58 SERPINC1 SERPINE1 SERPINF2
4 serine-type peptidase activity GO:0008236 9.56 F2 LPA PLG PRTN3
5 serine-type endopeptidase inhibitor activity GO:0004867 9.54 SERPINC1 SERPINE1 SERPINF2
6 apolipoprotein binding GO:0034185 9.43 LPA PLG
7 endopeptidase inhibitor activity GO:0004866 9.33 C3 LPA SERPINF2
8 serine-type endopeptidase activity GO:0004252 9.26 F2 LPA PLG PRTN3
9 heparin binding GO:0008201 9.02 ADA2 APOH F2 LPA SERPINC1

Sources for Livedoid Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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