MCID: LVD003
MIFTS: 42

Livedoid Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Skin diseases

Aliases & Classifications for Livedoid Vasculitis

MalaCards integrated aliases for Livedoid Vasculitis:

Name: Livedoid Vasculitis 12 53 15
Livedoid Vasculopathy 12 53
Livedo Reticularis with Summer Ulcerations 53
Livedo Reticularis with Winter Ulcerations 53
Segmental Hyalinizing Vasculopathy 53
Livedo Vasculitis 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0040099
ICD10 33 L95.0
ICD9CM 35 709.1

Summaries for Livedoid Vasculitis

NIH Rare Diseases : 53 Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

MalaCards based summary : Livedoid Vasculitis, also known as livedoid vasculopathy, is related to ischemic neuropathy and protein c deficiency. An important gene associated with Livedoid Vasculitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include skin, liver and heart, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A vasculitis with purpuric ulcers.

Wikipedia : 76 Livedoid vasculopathy (also known as "livedoid vasculitis", "livedo reticularis with summer/winter... more...

Related Diseases for Livedoid Vasculitis

Diseases related to Livedoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 ischemic neuropathy 30.3 F2 MTHFR
2 protein c deficiency 30.3 F2 MTHFR SERPINC1
3 antiphospholipid syndrome 30.2 APOH F2 MTHFR SERPINC1
4 homocysteinemia 30.2 F2 MTHFR SERPINC1
5 sneddon syndrome 30.1 APOH F2 SERPINC1
6 protein s deficiency 30.1 APOH F2 MTHFR SERPINC1
7 antithrombin iii deficiency 30.0 APOH F2 MTHFR SERPINC1
8 thrombophilia 29.8 APOH F2 F8 MTHFR SERPINC1 SERPINE1
9 intracranial thrombosis 29.6 APOH F8 MTHFR PLG SERPINC1
10 retinal artery occlusion 29.6 APOH F2 F8 MTHFR SERPINC1 SERPINE1
11 thrombosis 29.6 APOH F2 F8 MTHFR SERPINC1 SERPINE1
12 vasculitis 10.7
13 hemorrhagic fever 10.3 F2 SERPINC1
14 hepatitis 10.3
15 fibrinolytic defect 10.2 SERPINC1 SERPINE1
16 platelet aggregation, spontaneous 10.2 SERPINC1 SERPINF2
17 cerebral falx meningioma 10.2 F2 PLG
18 cold urticaria 10.2 SERPINC1 SERPINF2
19 sagittal sinus thrombosis 10.2 F2 SERPINC1
20 plasminogen activator inhibitor-1 deficiency 10.2 SERPINE1 SERPINF2
21 aspirin allergy 10.2 SERPINC1 SERPINE1
22 argentine hemorrhagic fever 10.2 SERPINC1 SERPINE1
23 sticky platelet syndrome 10.2 SERPINC1 SERPINE1
24 femoral neuropathy 10.2 F2 PLG
25 mesenteric vascular occlusion 10.2 F2 MTHFR
26 inferior vena cava interruption 10.2 MTHFR SERPINE1
27 tuberculous empyema 10.2 PLG SERPINE1
28 neonatal stroke 10.2 MTHFR SERPINE1
29 amaurosis fugax 10.2 MTHFR SERPINE1
30 acute poststreptococcal glomerulonephritis 10.2 PLG SERPINF2
31 esophageal varix 10.2 F2 SERPINC1
32 anterior cranial fossa meningioma 10.2 F2 PLG
33 cerebral sinovenous thrombosis 10.2 APOH F2
34 porencephaly 10.2 F2 MTHFR
35 meningococcemia 10.2 SERPINC1 SERPINE1
36 hepatitis b 10.2
37 mononeuritis multiplex 10.2
38 peripheral nervous system disease 10.2
39 hypersplenism 10.2 F2 SERPINC1
40 purpura fulminans 10.2 F2 SERPINC1 SERPINF2
41 dysbaric osteonecrosis 10.2 PLG SERPINE1
42 leech infestation 10.2 F2 PLG SERPINC1
43 papilledema 10.2 APOH F2
44 hemophilia 10.2 F2 F8
45 afibrinogenemia, congenital 10.2 F2 SERPINC1 SERPINF2
46 anterior spinal artery syndrome 10.2 F2 PLG SERPINC1
47 subendocardial myocardial infarction 10.2 F2 SERPINC1 SERPINE1
48 gastroschisis 10.2 F2 MTHFR
49 eclampsia 10.2 F2 MTHFR SERPINC1
50 cerebral arteritis 10.1 F8 PLG

Graphical network of the top 20 diseases related to Livedoid Vasculitis:



Diseases related to Livedoid Vasculitis

Symptoms & Phenotypes for Livedoid Vasculitis

MGI Mouse Phenotypes related to Livedoid Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 CALCR CASR F2 F8 PLG PRTN3
2 homeostasis/metabolism MP:0005376 9.9 APOH CALCR CASR F2 F8 MTHFR
3 immune system MP:0005387 9.61 CALCR CASR F2 F8 PLG PRTN3
4 mortality/aging MP:0010768 9.32 APOH CALCR CASR F2 F8 MTHFR

Drugs & Therapeutics for Livedoid Vasculitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Correlation of Genetic Polymorphism and Livedo Vasculitis Completed NCT00975871
2 Research of Prognostic Factors Associated With Healing of Venous Leg Ulcers Completed NCT01673412 Not Applicable
3 Characteristic of Drug Users Chronic Wound Not yet recruiting NCT03608384

Search NIH Clinical Center for Livedoid Vasculitis

Genetic Tests for Livedoid Vasculitis

Anatomical Context for Livedoid Vasculitis

MalaCards organs/tissues related to Livedoid Vasculitis:

41
Skin, Liver, Heart, Spinal Cord, Placenta, Endothelial

Publications for Livedoid Vasculitis

Articles related to Livedoid Vasculitis:

(show top 50) (show all 88)
# Title Authors Year
1
Systemic lupus erythematosus with refractory ulcerated livedoid vasculopathy: Successful treatment with intravenous immunoglobulin and warfarin. ( 30455888 )
2018
2
Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease. ( 29533274 )
2018
3
Traditional Korean medicine treatment for livedoid vasculopathy: Five case reports. ( 30100128 )
2018
4
Livedoid vasculopathy: a compelling diagnosis. ( 30101138 )
2018
5
Prevention of recurrent ulceration of livedoid vasculopathy with long-term apixaban monotherapy. ( 30156315 )
2018
6
Dermoscopy of early non-ulcerated livedoid vasculopathy. ( 30244265 )
2018
7
Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy. ( 28901563 )
2017
8
Successful Treatment of Livedoid Vasculitis with Primary Antiphospholipid Syndrome by Using Aspirin and Low Dose Warfarin Combination Therapy. ( 26512179 )
2015
9
Direct immunofluorescence findings and thrombophilic factors in livedoid vasculopathy: how do they correlate? ( 23692592 )
2014
10
Livedoid vasculopathy as a marker of systemic disease: report of two cases. ( 25184928 )
2014
11
Treatment of livedoid vasculopathy with alprostadil (PGE-1): case report and review of published literature. ( 22364635 )
2013
12
Rivaroxaban prevents painful cutaneous infarctions in livedoid vasculopathy. ( 23106384 )
2013
13
Livedoid vasculopathy--a vasculitic mimic. ( 23203724 )
2013
14
Livedoid vasculopathy - current aspects of diagnosis and treatment of cutaneous infarction. ( 23437985 )
2013
15
Intravenous immunoglobulins in difficult-to-treat ulcerated livedoid vasculopathy: five cases and a literature review. ( 23488633 )
2013
16
Livedoid vasculopathy successfully treated with hyperbaric oxygen. ( 23508660 )
2013
17
Livedoid vasculopathy - a thrombotic disease. ( 23989066 )
2013
18
Livedoid vasculopathy: an in-depth analysis using a modified Delphi approach. ( 24028907 )
2013
19
Association between peripheral vascular endothelial dysfunction and livedoid vasculopathy. ( 21982058 )
2012
20
Livedoid vasculopathy associated with sickle cell trait: significant improvement on aspirin treatment. ( 22044499 )
2012
21
Livedoid vasculopathy in a patient with lupus anticoagulant and MTHFR mutation: treatment with low-molecular-weight heparin. ( 22592843 )
2012
22
What caused this painful skin erosion? Livedoid vasculopathy. ( 22712143 )
2012
23
Update of management of connective tissue diseases: livedoid vasculopathy. ( 22741937 )
2012
24
Painless Livedoid Vasculopathy in a Patient with G20210A Prothrombin Gene Mutation. ( 22988463 )
2012
25
Livedoid vasculopathy. ( 23259203 )
2012
26
Livedoid vasculopathy: review of pathogenesis, clinical presentation, diagnostic workup, and treatment. ( 23409480 )
2012
27
Livedoid vasculopathy managed with hyperbaric oxygen therapy. ( 24532913 )
2012
28
Ischemic neuropathy associated with livedoid vasculitis. ( 22259622 )
2011
29
The significance of anticardiolipin antibody and immunologic abnormality in livedoid vasculitis. ( 21182497 )
2011
30
Livedoid vasculopathy as a coagulation disorder. ( 21184847 )
2011
31
Livedoid vasculopathy secondary to high levels of lipoprotein(a). ( 21219292 )
2011
32
Severe livedoid vasculopathy associated with antiphosphatidylserine-prothrombin complex antibody successfully treated with warfarin. ( 21576587 )
2011
33
Livedoid vasculopathy; favorable clinical response with low dose warfarin. ( 21914587 )
2011
34
Successful long-term use of intravenous immunoglobulin to treat livedoid vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity. ( 22006147 )
2011
35
Livedoid vasculopathy: an intringuing cutaneous disease. ( 22147037 )
2011
36
Livedoid vasculopathy: fast involution after anticoagulant and hyperbaric oxygen therapy. ( 26760818 )
2011
37
Livedoid vasculopathy: thrombotic or inflammatory disease? ( 19874344 )
2010
38
Case of livedoid vasculopathy with extensive dermal capillary thrombi. ( 20175829 )
2010
39
Case of livedoid vasculopathy with peripheral neuropathy successfully treated with low-dose warfarin. ( 20175830 )
2010
40
Livedoid vasculopathy in a woman with multiple myeloma. ( 20622720 )
2010
41
Livedoid vasculopathy in a pediatric patient with elevated lipoprotein(a) levels: prompt response to continuous low-molecular-weight heparin. ( 20713839 )
2010
42
Livedoid vasculopathy with underlying subcutaneous necrotizing venulitis in an asymptomatic hepatitis B virus carrier: is livedoid vasculopathy a true nonvasculitic disorder? ( 19384073 )
2009
43
Homeopathic treatment in resistant livedoid vasculopathy: case report. ( 19647211 )
2009
44
Livedoid vasculopathy and pregnancy. ( 19647821 )
2009
45
Ulcerations caused by livedoid vasculopathy associated with a prothrombotic state: Response to warfarin. ( 18280355 )
2008
46
A case of widespread livedoid vasculopathy with pain but no systemic symptoms. ( 18480943 )
2008
47
Successful use of rituximab in a patient with recalcitrant livedoid vasculopathy. ( 18556452 )
2008
48
Therapeutic effect of lipoprostaglandin E1 on livedoid vasculitis associated with essential cryoglobulinaemia. ( 17725674 )
2007
49
Heterozygous prothrombin gene mutation associated with livedoid vasculopathy. ( 17535202 )
2007
50
Livedoid vasculopathy. The role of hyperhomocysteinemia and its simple therapeutic consequences. ( 16581568 )
2006

Variations for Livedoid Vasculitis

Expression for Livedoid Vasculitis

Search GEO for disease gene expression data for Livedoid Vasculitis.

Pathways for Livedoid Vasculitis

GO Terms for Livedoid Vasculitis

Cellular components related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.95 APOH F2 PLG PRTN3 SERPINC1 SERPINE1
2 extracellular region GO:0005576 9.92 APOH F2 F8 PLG PRTN3 SERPINC1
3 cell surface GO:0009986 9.77 APOH CASR PLG SERPINF2 TNFRSF10A
4 extracellular space GO:0005615 9.76 APOH F2 F8 PLG PRTN3 SERPINC1
5 blood microparticle GO:0072562 9.56 F2 PLG SERPINC1 SERPINF2
6 platelet alpha granule lumen GO:0031093 9.26 F8 PLG SERPINE1 SERPINF2
7 collagen-containing extracellular matrix GO:0062023 9.1 APOH PLG PRTN3 SERPINC1 SERPINE1 SERPINF2
8 plasma membrane GO:0005886 10.09 CALCR CASR F2 F8 PLG PRTN3

Biological processes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.72 F2 F8 PLG PRTN3 SERPINC1
2 negative regulation of endopeptidase activity GO:0010951 9.7 SERPINC1 SERPINE1 SERPINF2
3 negative regulation of peptidase activity GO:0010466 9.69 SERPINC1 SERPINE1 SERPINF2
4 acute-phase response GO:0006953 9.63 F2 F8 SERPINF2
5 blood coagulation, intrinsic pathway GO:0007597 9.61 APOH F2 F8
6 positive regulation of blood coagulation GO:0030194 9.58 APOH F2 SERPINE1
7 hemostasis GO:0007599 9.56 F2 F8 PLG SERPINC1
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.55 SERPINE1 TNFRSF10A
9 platelet degranulation GO:0002576 9.55 APOH F8 PLG SERPINE1 SERPINF2
10 positive regulation of collagen biosynthetic process GO:0032967 9.54 F2 SERPINF2
11 regulation of blood coagulation GO:0030193 9.54 APOH F2 SERPINC1
12 negative regulation of blood coagulation GO:0030195 9.49 APOH SERPINE1
13 negative regulation of plasminogen activation GO:0010757 9.48 SERPINE1 SERPINF2
14 fibrinolysis GO:0042730 9.26 F2 PLG SERPINE1 SERPINF2
15 negative regulation of fibrinolysis GO:0051918 9.02 APOH F2 PLG SERPINE1 SERPINF2

Molecular functions related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.56 F2 PLG PRTN3 SERPINE1
2 heparin binding GO:0008201 9.54 APOH F2 SERPINC1
3 serine-type peptidase activity GO:0008236 9.5 F2 PLG PRTN3
4 peptidase inhibitor activity GO:0030414 9.33 SERPINC1 SERPINE1 SERPINF2
5 serine-type endopeptidase inhibitor activity GO:0004867 9.13 SERPINC1 SERPINE1 SERPINF2
6 protease binding GO:0002020 8.92 SERPINC1 SERPINE1 SERPINF2 TNFRSF10A

Sources for Livedoid Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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