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MCID: LVD003
MIFTS: 35

Livedoid Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Livedoid Vasculitis

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MalaCards integrated aliases for Livedoid Vasculitis:

Name: Livedoid Vasculitis 12 20 15 32
Livedoid Vasculopathy 12 20 58
Livedo Reticularis with Summer Ulcerations 20 58
Livedo Reticularis with Winter Ulcerations 20
Segmental Hyalinizing Vasculopathy 20
Segmental Hyalinizing Vasculitis 58
Milian Atrophie Blanche 58
Livedo Vasculitis 20

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare circulatory system diseases
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:0040099
ICD9CM 34 709.1
ICD10 32 L95.0
Orphanet 58 ORPHA542643
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Summaries for Livedoid Vasculitis

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GARD : 20 Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

MalaCards based summary : Livedoid Vasculitis, also known as livedoid vasculopathy, is related to purpura and sticky platelet syndrome. An important gene associated with Livedoid Vasculitis is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. Affiliated tissues include skin and endothelial.

Disease Ontology : 12 A vasculitis with purpuric ulcers.

Wikipedia : 74 Livedoid vasculopathy is a chronic cutaneous disease seen predominantly in young to middle-aged women.... more...

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Related Diseases for Livedoid Vasculitis

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Diseases related to Livedoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 purpura 30.4 SERPINC1 F2 APOH
2 sticky platelet syndrome 30.1 SERPINE1 SERPINC1
3 polyarteritis nodosa 29.8 APOH ADA2
4 chronic venous insufficiency 29.4 SERPINE1 MTHFR F2
5 venous insufficiency 29.4 SERPINE1 MTHFR F2
6 sneddon syndrome 29.4 SERPINC1 F2 APOH ADA2
7 central retinal artery occlusion 29.3 SERPINC1 PLG MTHFR F2
8 protein s deficiency 29.2 SERPINC1 MTHFR F2 APOH
9 disseminated intravascular coagulation 29.1 SERPINF2 SERPINE1 SERPINC1 PLG F2
10 protein c deficiency 29.1 SERPINE1 SERPINC1 MTHFR F2 APOH
11 thrombophilia 29.1 SERPINF2 SERPINE1 SERPINC1 MTHFR F2 APOH
12 antiphospholipid syndrome 29.1 SERPINE1 SERPINC1 MTHFR F2 APOH
13 branch retinal artery occlusion 28.9 SERPINC1 PLG MTHFR F2 APOH
14 antithrombin iii deficiency 28.8 SERPINC1 PLG MTHFR F2 APOH
15 intracranial thrombosis 28.8 SERPINC1 PLG MTHFR F2 APOH
16 thrombophilia due to thrombin defect 28.7 SERPINE1 SERPINC1 MTHFR F2 APOH
17 homocysteinemia 28.7 SERPINE1 SERPINC1 MTHFR F2 APOH
18 thrombophilia due to activated protein c resistance 28.6 SERPINE1 SERPINC1 PLG MTHFR F2 APOH
19 retinal artery occlusion 28.4 SERPINE1 SERPINC1 PLG MTHFR F2 APOH
20 thrombosis 28.1 SERPINF2 SERPINE1 SERPINC1 PLG MTHFR F2
21 stroke, ischemic 28.0 SERPINF2 SERPINE1 SERPINC1 PLG MTHFR F2
22 vasculitis 10.7
23 skin disease 10.4
24 dowling-degos disease 1 10.3
25 muscular dystrophy white matter spongiosis 10.3
26 telangiectasis 10.3
27 prothrombin deficiency 10.2 SERPINC1 F2
28 platelet aggregation, spontaneous 10.2 SERPINF2 SERPINC1
29 cold urticaria 10.2 SERPINF2 SERPINC1
30 collagen disease 10.2
31 waterhouse-friderichsen syndrome 10.2 SERPINC1 F2
32 cavernous sinus thrombosis 10.2 SERPINC1 F2
33 abducens nerve disease 10.2 SERPINC1 F2
34 intracranial hypotension 10.2 SERPINC1 F2
35 hepatic coma 10.2 SERPINC1 F2
36 pituitary adenoma 5, multiple types 10.2 SERPINC1 F2
37 vitamin k deficiency bleeding 10.2 SERPINC1 F2
38 leech infestation 10.2 SERPINC1 PLG
39 esophageal varix 10.2 SERPINC1 F2
40 septicemic plague 10.2 SERPINF2 PLG
41 plasminogen deficiency, type i 10.2 SERPINF2 PLG
42 anterior spinal artery syndrome 10.2 PLG F2
43 cerebral falx meningioma 10.2 PLG F2
44 basilar artery occlusion 10.2 PLG F2
45 acute pulmonary heart disease 10.1 PLG F2
46 puerperal pulmonary embolism 10.1 SERPINC1 APOH
47 perforated corneal ulcer 10.1 SERPINF2 PLG
48 acute cor pulmonale 10.1 PLG F2
49 dysfibrinogenemia, congenital 10.1 SERPINC1 F2
50 posterior cerebral artery infarction 10.1 PLG F2

Graphical network of the top 20 diseases related to Livedoid Vasculitis:



Diseases related to Livedoid Vasculitis
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Symptoms & Phenotypes for Livedoid Vasculitis

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Drugs & Therapeutics for Livedoid Vasculitis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Correlation of Genetic Polymorphism and Livedo Vasculitis Completed NCT00975871

Search NIH Clinical Center for Livedoid Vasculitis

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Genetic Tests for Livedoid Vasculitis

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Anatomical Context for Livedoid Vasculitis

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MalaCards organs/tissues related to Livedoid Vasculitis:

40
Skin, Endothelial
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Publications for Livedoid Vasculitis

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Articles related to Livedoid Vasculitis:

(show top 50) (show all 239)
# Title Authors PMID Year
1
Recrudescence of livedoid vasculopathy induced by COVID-19. 61
33527356 2021
2
Livedoid vasculopathy in 75 Brazilian patients in a single-center institution: Clinical, histopathological and therapy evaluation. 61
33496999 2021
3
Livedoid Vasculopathy Associated with Antiphospholipid Antibody Presenting with Leg Ulcer. 61
32451825 2020
4
Plasminogen activator inhibitor-1: a potential etiological role in livedoid vasculopathy. 61
33043622 2020
5
From dermatological conditions to COVID-19: Reasoning for anticoagulation, suppression of inflammation, and hyperbaric oxygen therapy. 61
33219572 2020
6
Unraveling the mystery of Covid-19 cytokine storm: From skin to organ systems. 61
32559324 2020
7
Refractory ulcerations associated with livedoid vasculopathy successfully treated with tofacitinib. 61
33112475 2020
8
Livedoid vasculopathy: Clinical course and long-term outcome in Asian patients with a review of the literature. 61
33219608 2020
9
[Diagnosis and treatment of vasculitic ulcerations]. 61
32997218 2020
10
[Non-healing wounds]. 61
33201630 2020
11
Intravenous Immunoglobulins in a Series of 32 Rare and Recalcitrant Immune Dermatoses. 61
33047147 2020
12
Vasculitic mononeuritis multiplex associated with livedoid vasculopathy. 61
31771777 2020
13
Direct immunofluorescence findings in livedoid vasculopathy: a 10-year study and literature review. 61
32986882 2020
14
Clinical and dermoscopic features of livedoid vasculopathy. 61
32804736 2020
15
A 75-year-old woman with primary antiphospholipid syndrome presenting with livedoid vasculopathy. 61
32359084 2020
16
Livedoid vasculopathy: A challenging disease to diagnose. 61
32619286 2020
17
Primary livedoid vasculopathy associated with mononeuritis multiplex. 61
32898400 2020
18
Methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism in Korean livedoid vasculopathy patients. 61
32599117 2020
19
Endovenous Laser Ablation Treatment for Lower Extremity Ulcers Associated With Livedoid Vasculopathy. 61
30882502 2020
20
Successful Treatment of Painful Cutaneous Vasculopathy With Rivaroxaban in a Patient With Systemic Lupus Erythematosus. 61
32484618 2020
21
Livedoid vasculopathy in Koreans: clinical features and response to rivaroxaban treatment. 61
31793049 2020
22
Livedoid vasculopathy in a patient with bullous pemphigoid and primary Sjögren's syndrome. 61
29526676 2020
23
Intravenous immunoglobulin in resistant livedoid vasculopathy: Analysis of a case series. 61
31965687 2020
24
Efficacy of an anti-TNF-alpha agent in refractory livedoid vasculopathy: a retrospective analysis. 61
32116074 2020
25
ADA2 Deficiency: Case Series of Five Patients with Varying Phenotypes. 61
31848804 2020
26
Recognition and Management of Cutaneous Polyarteritis Nodosum Versus Livedoid Vasculitis: A Case Report. 61
32140348 2020
27
Chronic leg ulcerations associated with livedoid vasculopathy successfully treated with rivaroxaban. 61
30767258 2020
28
Livedoid vasculopathy presenting with leg ulcers. 61
31220328 2019
29
Is there a role for hyperbaric oxygen therapy in the treatment of refractory wounds of rare etiology? 61
31523797 2019
30
Livedoid vasculopathy: how to diagnose and how to treat? 61
31468610 2019
31
Characteristics, risk factors and treatment reality in livedoid vasculopathy - a multicentre analysis. 61
31009111 2019
32
Topical becaplermin gel is an effective adjuvant for long-standing ulcers of livedoid vasculopathy recalcitrant to anticoagulant therapy. 61
30706539 2019
33
Retiform non-blanchable purpuric plaques in a patient with systemic lupus erythematosus. 61
31126212 2019
34
Livedoid vasculopathy: does hyperhomocysteinaemia play an aetiological role? 61
31389788 2019
35
Prevention of recurrent ulceration of livedoid vasculopathy with long-term apixaban monotherapy. 61
30156315 2019
36
Atypical Mycobacterial Infection Arising Amid Corticosteroid Therapy for Livedoid Vasculopathy. 61
31687220 2019
37
Systemic lupus erythematosus with refractory ulcerated livedoid vasculopathy: Successful treatment with intravenous immunoglobulin and warfarin. 61
30455888 2018
38
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options. 61
29738044 2018
39
Dermoscopy of early non-ulcerated livedoid vasculopathy. 61
30244265 2018
40
Traditional Korean medicine treatment for livedoid vasculopathy: Five case reports. 61
30100128 2018
41
Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease. 61
29533274 2018
42
Systemic therapies for leg ulcers. 61
29989361 2018
43
Livedoid vasculopathy: a compelling diagnosis. 61
30101138 2018
44
The management of livedoid vasculopathy focused on direct oral anticoagulants (DOACs): four case reports successfully treated with rivaroxaban. 61
29663354 2018
45
Three cases of lymphocytic thrombophilic arteritis presenting with an annular eruption. 61
28752544 2018
46
Treatment of Livedoid Vasculopathy With Rivaroxaban: A Potential Use of New Oral Anticoagulants for Dermatologists. 61
29074145 2018
47
Ulcerative livedoid vasculopathy responding to clopidogrel. 61
29892667 2018
48
Treatment for Livedoid Vasculopathy: A Systematic Review. 61
29141075 2018
49
Systemic Lupus Erythematosus Presenting as Livedoid Vasculopathy over the Forearms. 61
29911533 2018
50
Vasculopathies, cutaneous necrosis and emergency in dermatology. 61
28845953 2017
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Variations for Livedoid Vasculitis

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Expression for Livedoid Vasculitis

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Search GEO for disease gene expression data for Livedoid Vasculitis.
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Pathways for Livedoid Vasculitis

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Pathways related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 12.81 SERPINF2 SERPINE1 SERPINC1 PLG F2 APOH
2
Folate Metabolism 1
Show member pathways
 11.96 SERPINE1 PLG MTHFR F2
3
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.56 SERPINF2 SERPINE1 SERPINC1 PLG F2
4
Cell adhesion_ECM remodeling 23
11.22 SERPINE1 PLG
5
Complement and coagulation cascades 36 1
11.18 SERPINF2 SERPINE1 SERPINC1 PLG F2
6
Syndecan-4-mediated signaling events 1
10.9 PLG F2
7
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 65
10.69 PLG F2
8
Dissolution of Fibrin Clot 65
10.45 SERPINF2 SERPINE1 PLG
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GO Terms for Livedoid Vasculitis

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Cellular components related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 SERPINF2 SERPINE1 SERPINC1 PLG F2 APOH
2 extracellular region GO:0005576 9.8 SERPINF2 SERPINE1 SERPINC1 PLG F2 APOH
3 extracellular space GO:0005615 9.7 SERPINF2 SERPINE1 SERPINC1 PLG F2 APOH
4 platelet alpha granule lumen GO:0031093 9.5 SERPINF2 SERPINE1 PLG
5 blood microparticle GO:0072562 9.26 SERPINF2 SERPINC1 PLG F2
6 collagen-containing extracellular matrix GO:0062023 9.1 SERPINF2 SERPINE1 SERPINC1 PLG F2 APOH

Biological processes related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.7 SERPINC1 PLG F2
2 negative regulation of endopeptidase activity GO:0010951 9.67 SERPINF2 SERPINE1 SERPINC1
3 cellular protein metabolic process GO:0044267 9.67 SERPINC1 PLG F2 ADA2
4 negative regulation of peptidase activity GO:0010466 9.63 SERPINF2 SERPINE1 SERPINC1
5 platelet degranulation GO:0002576 9.62 SERPINF2 SERPINE1 PLG APOH
6 hemostasis GO:0007599 9.58 SERPINC1 PLG F2
7 acute-phase response GO:0006953 9.55 SERPINF2 F2
8 positive regulation of collagen biosynthetic process GO:0032967 9.54 SERPINF2 F2
9 blood coagulation, intrinsic pathway GO:0007597 9.51 F2 APOH
10 negative regulation of blood coagulation GO:0030195 9.48 SERPINE1 APOH
11 negative regulation of plasminogen activation GO:0010757 9.43 SERPINF2 SERPINE1
12 positive regulation of blood coagulation GO:0030194 9.43 SERPINE1 F2 APOH
13 regulation of blood coagulation GO:0030193 9.33 SERPINC1 F2 APOH
14 fibrinolysis GO:0042730 9.26 SERPINF2 SERPINE1 PLG F2
15 negative regulation of fibrinolysis GO:0051918 9.02 SERPINF2 SERPINE1 PLG F2 APOH

Molecular functions related to Livedoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 9.43 SERPINF2 SERPINE1 SERPINC1
2 protease binding GO:0002020 9.33 SERPINF2 SERPINE1 SERPINC1
3 serine-type endopeptidase inhibitor activity GO:0004867 9.13 SERPINF2 SERPINE1 SERPINC1
4 heparin binding GO:0008201 8.92 SERPINC1 F2 APOH ADA2
Sources

Sources for Livedoid Vasculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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