MCID: LVD002
MIFTS: 37

Livedoid Vasculopathy

Categories: Rare diseases, Skin diseases, Cardiovascular diseases

Aliases & Classifications for Livedoid Vasculopathy

MalaCards integrated aliases for Livedoid Vasculopathy:

Name: Livedoid Vasculopathy 53
Livedoid Vasculitis 53 73
Livedo Vasculitis 53 73
Livedo Reticularis with Summer Ulcerations 53
Livedo Reticularis with Winter Ulcerations 53
Segmental Hyalinizing Vasculopathy 53

Classifications:



External Ids:

ICD10 33 L95.0

Summaries for Livedoid Vasculopathy

NIH Rare Diseases : 53 Livedoid vasculopathy is a blood vessel disorder that causes painful ulcers and scarring (atrophie blanche) on the feet and lower legs. These symptoms can persist for months to years and the ulcers often recur. Livedoid vasculopathy lesions appear as painful red or purple marks and spots that may progress to small, tender, irregular ulcers. Symptoms tend to worsen in the winter and summer months, and affect women more often then men. Livedoid vasculopathy may occur alone or in combination with another condition, such as lupus or thrombophilia.

MalaCards based summary : Livedoid Vasculopathy, also known as livedoid vasculitis, is related to sticky platelet syndrome and acute liver failure. An important gene associated with Livedoid Vasculopathy is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. Affiliated tissues include skin, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 76 Livedoid vasculopathy (also known as \"livedoid vasculitis\", \"livedo reticularis with summer/winter... more...

Related Diseases for Livedoid Vasculopathy

Diseases related to Livedoid Vasculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 sticky platelet syndrome 30.6 F5 SERPINE1
2 acute liver failure 30.3 F2 F5
3 hepatitis a 30.0 CD40LG F2
4 sneddon syndrome 28.9 APOH F2 F5
5 vasculitis 28.6 APOH CD40LG
6 protein s deficiency 28.0 APOH F2 F5 MTHFR
7 retinal artery occlusion 27.2 APOH F2 F5 MTHFR SERPINE1
8 thrombosis 27.2 APOH F2 F5 MTHFR SERPINE1
9 thrombophilia 27.2 APOH F2 F5 MTHFR SERPINE1
10 antiphospholipid syndrome 27.1 APOH CD40LG F2 F5 MTHFR
11 stroke, ischemic 27.0 APOH F2 F5 MTHFR SERPINE1
12 meningococcemia 10.4 F5 SERPINE1
13 factor xiii deficiency 10.4 F5 SERPINE1
14 paracetamol poisoning 10.4 F2 F5
15 quebec platelet disorder 10.4 F5 SERPINE1
16 hemoglobin e disease 10.4 F2 F5
17 sagittal sinus thrombosis 10.4 F2 F5
18 factor viii deficiency 10.4 F2 F5
19 scott syndrome 10.3 F2 F5
20 blue toe syndrome 10.3 F2 SERPINE1
21 dysfibrinogenemia 10.3 F2 F5
22 subendocardial myocardial infarction 10.3 F2 SERPINE1
23 severe hemophilia a 10.3 F2 F5
24 fournier gangrene 10.3 CD40LG F2
25 factor x deficiency 10.2 F2 F5
26 afibrinogenemia 10.2 F2 F5
27 hantavirus pulmonary syndrome 10.2 CD40LG F2
28 venous insufficiency 10.2 F2 SERPINE1
29 neonatal stroke 10.2 MTHFR SERPINE1
30 splenic disease 10.2 CD40LG F2
31 von willebrand's disease 10.2 F2 F5
32 hepatitis d 10.2 CD40LG F2
33 korean hemorrhagic fever 10.2 CD40LG F2
34 factor v deficiency 10.2 F2 F5
35 hemorrhagic fever 10.2 CD40LG F2
36 endocardium disease 10.2 CD40LG F2
37 lemierre's syndrome 10.2 MTHFR SERPINE1
38 hepatitis e 10.2 CD40LG F2
39 schizencephaly 10.2 F5 MTHFR
40 mesenteric vascular occlusion 10.1 F2 MTHFR
41 leptospirosis 10.1 CD40LG F2
42 blood protein disease 10.1 F2 MTHFR
43 adult respiratory distress syndrome 10.1 F2 SERPINE1
44 ischemic neuropathy 10.1 F2 MTHFR
45 marantic endocarditis 10.1 F2 MTHFR
46 dengue hemorrhagic fever 10.1 CD40LG F2
47 may-thurner syndrome 10.1 APOH F5
48 mononeuritis multiplex 10.1
49 acanthamoeba keratitis 10.1 APOH F5
50 pregnancy loss, recurrent 1 10.0 APOH F5

Graphical network of the top 20 diseases related to Livedoid Vasculopathy:



Diseases related to Livedoid Vasculopathy

Symptoms & Phenotypes for Livedoid Vasculopathy

MGI Mouse Phenotypes related to Livedoid Vasculopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.63 SERPINE1 APOH CD40LG F2 F5 MTHFR
2 integument MP:0010771 9.35 SERPINE1 CD40LG F2 F5 MTHFR
3 mortality/aging MP:0010768 9.1 SERPINE1 APOH CD40LG F2 F5 MTHFR

Drugs & Therapeutics for Livedoid Vasculopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Correlation of Genetic Polymorphism and Livedo Vasculitis Completed NCT00975871
2 Research of Prognostic Factors Associated With Healing of Venous Leg Ulcers Completed NCT01673412 Not Applicable

Search NIH Clinical Center for Livedoid Vasculopathy

Genetic Tests for Livedoid Vasculopathy

Anatomical Context for Livedoid Vasculopathy

MalaCards organs/tissues related to Livedoid Vasculopathy:

41
Skin

Publications for Livedoid Vasculopathy

Articles related to Livedoid Vasculopathy:

(show top 50) (show all 76)
# Title Authors Year
1
Ulcerative livedoid vasculopathy responding to clopidogrel. ( 29892667 )
2018
2
Systemic Lupus Erythematosus Presenting as Livedoid Vasculopathy over the Forearms. ( 29911533 )
2018
3
The management of livedoid vasculopathy focused on direct oral anticoagulants (DOACs): four case reports successfully treated with rivaroxaban. ( 29663354 )
2018
4
Treatment for Livedoid Vasculopathy: A Systematic Review. ( 29141075 )
2018
5
Livedoid vasculopathy in a patient with bullous pemphigoid and primary SjAPgren's syndrome. ( 29526676 )
2018
6
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options. ( 29738044 )
2018
7
Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease. ( 29533274 )
2018
8
Prevention of livedoid vasculopathy recurrence by prolonged administration of rivaroxaban. ( 28609556 )
2017
9
Use of Low-dose Oral Warfarin in Three Cases of Livedoid Vasculopathy. ( 28979014 )
2017
10
Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis. ( 28252815 )
2017
11
Efficacy of new low-dose oral anticoagulants in recalcitrant livedoid vasculopathy. ( 28739563 )
2017
12
Treatment application of rivaroxaban in Chinese patients with livedoid vasculopathy. ( 28360530 )
2017
13
Dermoscopic features of livedoid vasculopathy. ( 28296736 )
2017
14
Livedoid Vasculopathy. ( 28511282 )
2017
15
Enhanced mRNA expression of plasminogen activator inhibitor-1 in livedoid vasculopathy lesions. ( 28186689 )
2017
16
Dabigatran in the management of livedoid vasculopathy. ( 28052437 )
2017
17
Treatment of Livedoid Vasculopathy With Rivaroxaban: A Potential Use of New Oral Anticoagulants for Dermatologists. ( 29074145 )
2017
18
Fast Cicatrization of Extensive Livedoid Vasculopathy Ulcers under Treatment with Sildenafil. ( 28223767 )
2017
19
Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy. ( 28901563 )
2017
20
Livedoid vasculopathy. ( 27914604 )
2016
21
Livedoid vasculopathy. ( 26952873 )
2016
22
New hope for patients with livedoid vasculopathy. ( 26853641 )
2016
23
Anticoagulation with rivaroxaban for livedoid vasculopathy (RILIVA): a multicentre, single-arm, open-label, phase 2a, proof-of-concept trial. ( 26853646 )
2016
24
Livedoid vasculopathy: A review of pathogenesis and principles of management. ( 27297279 )
2016
25
Livedoid vasculopathy - a challenging disease. ( 27155327 )
2016
26
Recalcitrant Livedoid Vasculopathy Associated with Hyperhomocysteinaemia Responding to Folic Acid and Vitamins B6/B12 Supplementation. ( 27001413 )
2016
27
Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. ( 27774697 )
2016
28
Livedoid Vasculopathy Associated with HIV Infection in Two Patients: A Causal Relationship? ( 26778817 )
2016
29
Case series of recalcitrant livedoid vasculopathy treated with rivaroxaban. ( 26993107 )
2016
30
Rapid remission of severe pain from livedoid vasculopathy by apixaban. ( 27166520 )
2016
31
Cilostazol: A novel agent in recalcitrant livedoid vasculopathy. ( 26345653 )
2015
32
Therapeutic effect of autologous platelet-rich plasma (PRP) on recalcitrant cutaneous ulcers in livedoid vasculopathy. ( 27051763 )
2015
33
Successful Treatment of Livedoid Vasculitis with Primary Antiphospholipid Syndrome by Using Aspirin and Low Dose Warfarin Combination Therapy. ( 26512179 )
2015
34
Livedoid Vasculopathy with Hyperhomocysteinemia Responding to Hyperbaric Oxygen Therapy. ( 26538741 )
2015
35
Response of livedoid vasculopathy to rivaroxaban. ( 25255997 )
2015
36
Pulsed intravenous immunoglobulin therapy in refractory ulcerated livedoid vasculopathy: seven cases and a literature review. ( 25845419 )
2015
37
Expanding the spectrum of livedoid vasculopathy: peculiar neuromuscular manifestations. ( 25871345 )
2015
38
Successful treatment of livedoid vasculopathy with rivaroxaban. ( 27051773 )
2015
39
Mononeuritis multiplex associated with primary livedoid vasculopathy: Neuropathological evidence of ischemic nerve damage. ( 25798525 )
2015
40
Lipoprotein(a) and livedoid vasculopathy: A new thrombophilic factor? ( 26328479 )
2015
41
Livedoid vasculopathy and high levels of lipoprotein (a): response to danazol. ( 25824252 )
2015
42
Sensory ganglionopathy with livedoid vasculopathy controlled by immunotherapy. ( 25196820 )
2015
43
Livedoid vasculopathy (LV) associated with sticky platelets syndrome type 3 (SPS type 3) and enhanced activity of plasminogen activator inhibitor (PAI-1) anomalies. ( 25131360 )
2014
44
Quality-of-life impairment in patients with livedoid vasculopathy. ( 25437971 )
2014
45
A Phase II Multicenter Trial With Rivaroxaban in the Treatment of Livedoid Vasculopathy Assessing Pain on a Visual Analog Scale. ( 25500152 )
2014
46
Efficacy of intravenous immunoglobulins in livedoid vasculopathy: long-term follow-up of 11 patients. ( 25022849 )
2014
47
Atrophie blanche: is it associated with venous disease or livedoid vasculopathy? ( 25325229 )
2014
48
Livedoid vasculopathy: clinical features and treatment in 24 Chinese patients. ( 24352295 )
2014
49
Livedoid vasculopathy as a marker of systemic disease: report of two cases. ( 25184928 )
2014
50
Livedoid vasculopathy managed with Hyperbaric oxygen therapy. ( 24600105 )
2013

Variations for Livedoid Vasculopathy

Expression for Livedoid Vasculopathy

Search GEO for disease gene expression data for Livedoid Vasculopathy.

Pathways for Livedoid Vasculopathy

GO Terms for Livedoid Vasculopathy

Cellular components related to Livedoid Vasculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 APOH CD40LG F2 F5 SERPINE1
2 platelet alpha granule lumen GO:0031093 9.16 F5 SERPINE1
3 extracellular space GO:0005615 9.02 APOH CD40LG F2 F5 SERPINE1

Biological processes related to Livedoid Vasculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.65 CD40LG F2 SERPINE1
2 hemostasis GO:0007599 9.46 F2 F5
3 blood circulation GO:0008015 9.43 F5 MTHFR
4 fibrinolysis GO:0042730 9.4 F2 SERPINE1
5 blood coagulation, intrinsic pathway GO:0007597 9.37 APOH F2
6 platelet degranulation GO:0002576 9.33 APOH F5 SERPINE1
7 negative regulation of blood coagulation GO:0030195 9.32 APOH SERPINE1
8 regulation of blood coagulation GO:0030193 9.26 APOH F2
9 positive regulation of blood coagulation GO:0030194 9.13 APOH F2 SERPINE1
10 negative regulation of fibrinolysis GO:0051918 8.8 APOH F2 SERPINE1

Sources for Livedoid Vasculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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