MCID: LVR002
MIFTS: 46

Liver Angiosarcoma

Categories: Rare diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Liver Angiosarcoma

MalaCards integrated aliases for Liver Angiosarcoma:

Name: Liver Angiosarcoma 12 15
Angiosarcoma of the Liver 76 53
Angiosarcoma of Liver 12 73
Hemangiosarcoma of the Liver 12
Hepatic Angiosarcoma 37

Classifications:



External Ids:

Disease Ontology 12 DOID:268
ICD10 33 C22.3
NCIt 50 C4438
SNOMED-CT 68 109844006 187770005
KEGG 37 H01557
UMLS 73 C0345907

Summaries for Liver Angiosarcoma

Disease Ontology : 12 An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located in the liver.

MalaCards based summary : Liver Angiosarcoma, also known as angiosarcoma of the liver, is related to angiosarcoma and hepatocellular carcinoma. An important gene associated with Liver Angiosarcoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include the liver, liver and endothelial, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Wikipedia : 76 Angiosarcoma is a cancer of the cells that line the walls of blood vessels or lymphatic vessels. The... more...

Related Diseases for Liver Angiosarcoma

Diseases related to Liver Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 31.3 KRAS VIM VWF
2 hepatocellular carcinoma 26.4 CAMTA1 CD34 CDK4 HRAS KRAS KRT19
3 regional odontodysplasia 11.0 KRT19 VIM
4 histiocytoid hemangioma 10.8 CAMTA1 HBA1
5 rare adenocarcinoma of the breast 10.8 KRAS TP53
6 adenoid squamous cell carcinoma 10.8 HBA1 VIM
7 syringocystadenoma papilliferum 10.7 KRAS VIM
8 hyperplastic polyposis syndrome 10.7 KRAS TP53
9 bednar tumor 10.7 ENO2 VIM
10 sigmoid neoplasm 10.7 HRAS KRAS
11 primitive neuroectodermal tumor of the cervix uteri 10.7 ENO2 VIM
12 spindle cell lipoma 10.7 CDK4 VIM
13 glomangiomyoma 10.6 CD34 VIM
14 apocrine adenoma 10.6 HRAS KRAS
15 papillary tumor of the pineal region 10.6 ENO2 VIM
16 sternum cancer 10.6 CD34 VIM
17 ring chromosome 7 10.6 CDK4 TP53
18 giant congenital nevus 10.6 HRAS NRAS
19 epulis 10.6 ENO2 VIM
20 periampullary adenoma 10.6 HRAS KRAS
21 ossifying fibromyxoid tumor 10.6 ENO2 VIM
22 paronychia 10.6 HRAS KRAS
23 ovary sarcoma 10.6 CD34 HBA1
24 ovarian angiosarcoma 10.6 CD34 HBA1
25 intravascular fasciitis 10.6 CD34 HBA1
26 epithelioid leiomyosarcoma 10.6 ENO2 VIM
27 pediatric angiosarcoma 10.5 CD34 HBA1
28 thyroid angiosarcoma 10.5 CD34 HBA1
29 pinguecula 10.5 CYP2E1 KRT19 TP53
30 infiltrating angiolipoma 10.5 CDK4 VWF
31 chordoma 10.5 KRT19 TP53 VIM
32 intrahepatic cholangiocarcinoma 10.5 KRAS KRT19 TP53
33 neurogenic arthropathy 10.5 CD34 HBA1
34 vascular cancer 10.5 CAMTA1 HBA1 VWF
35 benign struma ovarii 10.5 HRAS NRAS
36 bone epithelioid hemangioma 10.5 CD34 HBA1
37 mutyh-associated polyposis 10.5 KRAS TP53
38 thyroid sarcoma 10.5 CD34 HBA1
39 hobnail hemangioma 10.5 CD34 HBA1
40 cellular neurofibroma 10.5 CD34 TP53
41 anal canal adenocarcinoma 10.4 HRAS KRAS KRT19
42 bile duct cysts 10.4 HRAS KRAS
43 colloid carcinoma of the pancreas 10.4 HRAS KRAS KRT19
44 ovarian melanoma 10.4 HRAS NRAS
45 glomeruloid hemangioma 10.4 CD34 HBA1
46 meninges sarcoma 10.4 CD34 TP53
47 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS KRAS NRAS
48 pericardium cancer 10.4 ENO2 HBA1 KRT19
49 hemangioma of liver 10.4 CD34 HBA1
50 embryonal sarcoma 10.4 CDK4 TP53 VIM

Graphical network of the top 20 diseases related to Liver Angiosarcoma:



Diseases related to Liver Angiosarcoma

Symptoms & Phenotypes for Liver Angiosarcoma

GenomeRNAi Phenotypes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CD34 CDK4 HRAS KRAS NRAS VIM

MGI Mouse Phenotypes related to Liver Angiosarcoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 NRAS TP53 HRAS CDK4 KRAS CYP2E1
2 cardiovascular system MP:0005385 10.29 VIM KRT19 TP53 NRAS HRAS CDK4
3 cellular MP:0005384 10.28 NRAS KRT19 TP53 CD34 CDK4 KRAS
4 growth/size/body region MP:0005378 10.24 NRAS KRAS TFE3 KRT19 TP53 HRAS
5 homeostasis/metabolism MP:0005376 10.22 TP53 NRAS KRAS CD34 HRAS CDK4
6 digestive/alimentary MP:0005381 10.18 KRT19 TP53 NRAS HRAS CDK4 KRAS
7 mortality/aging MP:0010768 10.18 TFE3 KRT19 TP53 NRAS HRAS CDK4
8 immune system MP:0005387 10.16 NRAS KRAS TFE3 TP53 CD34 CDK4
9 endocrine/exocrine gland MP:0005379 10.11 TP53 NRAS KRAS KRT19 HRAS CDK4
10 integument MP:0010771 10.09 NRAS TFE3 KRT19 TP53 HRAS CDK4
11 neoplasm MP:0002006 10.02 KRT19 TP53 NRAS HRAS CDK4 KRAS
12 nervous system MP:0003631 9.96 TP53 KRAS KRT19 ENO2 HRAS CDK4
13 liver/biliary system MP:0005370 9.95 NRAS KRAS TP53 CDK4 CYP2E1 YAP1
14 normal MP:0002873 9.76 TP53 NRAS KRAS TFE3 KRT19 HRAS
15 pigmentation MP:0001186 9.35 NRAS KRAS TFE3 TP53 CDK4
16 respiratory system MP:0005388 9.17 KRAS TP53 HRAS ENO2 VIM YAP1

Drugs & Therapeutics for Liver Angiosarcoma

Drugs for Liver Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification, Molecular Epidemiology Angiosarcoma of the Liver France Unknown status NCT01786889 Not Applicable
2 Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation Completed NCT03025438

Search NIH Clinical Center for Liver Angiosarcoma

Genetic Tests for Liver Angiosarcoma

Anatomical Context for Liver Angiosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Liver Angiosarcoma:

19
The Liver

MalaCards organs/tissues related to Liver Angiosarcoma:

41
Liver, Endothelial, Brain

Publications for Liver Angiosarcoma

Articles related to Liver Angiosarcoma:

(show all 27)
# Title Authors Year
1
Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report. ( 27718433 )
2016
2
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker. ( 27544804 )
2016
3
Surveillance for angiosarcoma of the liver among vinyl chloride workers. ( 25376416 )
2014
4
Chemoembolisation combined with percutaneous radiofrequency ablation in the treatment of primary angiosarcoma of the liver. ( 23704445 )
2013
5
Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report. ( 22280556 )
2012
6
Angiosarcoma of the liver as a cause of fulminant liver failure. ( 22865805 )
2012
7
Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy. ( 21997379 )
2012
8
Widening spectrum of liver angiosarcoma in children. ( 21832953 )
2011
9
Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. ( 20546460 )
2010
10
A case-cohort study of angiosarcoma of the liver and brain cancer at a polymer production plant. ( 12762079 )
2003
11
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride. ( 12211074 )
2002
12
p16INK4A-alterations in primary angiosarcoma of the liver. ( 11495043 )
2001
13
Metastatic angiosarcoma of the liver preoperatively presenting as giant hemangioma. ( 11070413 )
2000
14
Establishment and characterization of a spontaneously immortalized myofibroblast cell line derived from a human liver angiosarcoma. ( 10952247 )
2000
15
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. ( 10964802 )
2000
16
Diffuse liver angiosarcoma and cerebral cavernous angiomas in a young patient. ( 10692780 )
1999
17
Sporadic and Thorotrast-induced angiosarcomas of the liver manifest frequent and multiple point mutations in K-ras-2. ( 9010458 )
1997
18
Two new cases of liver angiosarcoma: history and perspectives of liver angiosarcoma among plastic industry workers. ( 9284534 )
1997
19
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. ( 9277092 )
1996
20
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. ( 1793483 )
1991
21
Massive bleeding after fine needle aspiration of liver angiosarcoma. ( 2298353 )
1990
22
Invasive character of malignant endothelial cells in vinyl-chloride-induced liver angiosarcoma. ( 2381457 )
1990
23
Liver angiosarcoma in a vinyl chloride polymerization plant worker. Report of the seventh Italian case. ( 3173221 )
1988
24
Iatrogenic disease. Lipoid pneumonia and liver angiosarcoma. ( 3714604 )
1986
25
Two cases of liver angiosarcoma among polyvinyl chloride (PVC) extruders of an Italian factory producing PVC bags and other containers. ( 6539068 )
1984
26
Log normal distribution of the incubation period of liver angiosarcoma in vinyl chloride polymerization workers. ( 569691 )
1979
27
Persistence of DNA damage during development of liver angiosarcoma in rats fed dimethylnitrosamine. ( 570883 )
1979

Variations for Liver Angiosarcoma

Expression for Liver Angiosarcoma

Search GEO for disease gene expression data for Liver Angiosarcoma.

Pathways for Liver Angiosarcoma

Pathways related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 CDK4 HRAS KRAS NRAS TP53 VWF
2
Show member pathways
12.85 CDK4 HRAS KRAS NRAS TP53
3 12.82 CDK4 HRAS KRAS NRAS TP53
4
Show member pathways
12.76 CDK4 HRAS KRAS NRAS TP53
5
Show member pathways
12.75 CDK4 HRAS KRAS NRAS TP53
6
Show member pathways
12.58 HRAS KRAS NRAS TP53 YAP1
7
Show member pathways
12.56 CDK4 HRAS KRAS NRAS TP53
8
Show member pathways
12.51 HRAS KRAS NRAS TP53
9 12.5 HRAS KRAS NRAS TP53 VIM
10
Show member pathways
12.48 HRAS KRAS NRAS TP53
11
Show member pathways
12.43 HRAS KRAS NRAS TP53
12
Show member pathways
12.42 HRAS KRAS NRAS TFE3 TP53
13
Show member pathways
12.41 CDK4 HRAS KRAS NRAS
14
Show member pathways
12.35 CDK4 HRAS KRAS NRAS VIM
15 12.34 CDK4 HRAS KRAS NRAS TP53
16
Show member pathways
12.29 HRAS KRAS NRAS VWF
17 12.29 HRAS KRAS NRAS TP53
18
Show member pathways
12.21 HRAS KRAS NRAS TP53
19
Show member pathways
12.18 HRAS KRAS NRAS TP53
20
Show member pathways
12.15 HRAS KRAS NRAS TP53
21
Show member pathways
12.14 HRAS KRAS NRAS TP53
22 12.11 CDK4 HRAS KRAS NRAS TP53
23
Show member pathways
12.08 HRAS KRAS NRAS VWF
24 12.06 HRAS KRAS NRAS TP53
25
Show member pathways
12.04 CDK4 HRAS KRAS NRAS
26 11.99 CDK4 HRAS KRAS NRAS TP53
27 11.98 HRAS KRAS NRAS TP53
28 11.96 HRAS KRAS NRAS TP53
29 11.95 HRAS KRAS NRAS
30 11.95 HRAS KRAS NRAS
31 11.95 HRAS KRAS NRAS TP53
32
Show member pathways
11.9 HRAS KRAS NRAS YAP1
33 11.86 CDK4 HRAS KRAS NRAS TP53
34
Show member pathways
11.85 HRAS KRAS NRAS
35
Show member pathways
11.84 HRAS KRAS NRAS
36 11.83 HRAS KRAS NRAS
37 11.82 CDK4 HRAS KRAS NRAS
38
Show member pathways
11.8 HRAS KRAS NRAS
39
Show member pathways
11.68 HRAS KRAS NRAS
40 11.64 HRAS KRAS NRAS
41 11.6 HRAS KRAS NRAS
42 11.6 CDK4 HRAS KRAS NRAS TP53
43 11.53 HRAS KRAS NRAS
44 11.48 HRAS KRAS NRAS TP53
45 11.47 HRAS KRAS NRAS
46 11.34 HRAS KRAS NRAS
47 11.27 HRAS KRAS NRAS
48 11.26 HRAS KRAS NRAS
49
Show member pathways
11.23 HRAS KRAS NRAS
50 11.23 HRAS KRAS NRAS TP53

GO Terms for Liver Angiosarcoma

Cellular components related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 CAMTA1 CDK4 ENO2 HBA1 HRAS KRAS

Biological processes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 CAMTA1 HRAS TFE3 TP53 WWTR1 YAP1
2 positive regulation of cell proliferation GO:0008284 9.88 CDK4 HRAS KRAS WWTR1 YAP1
3 leukocyte migration GO:0050900 9.76 CD34 HRAS KRAS NRAS
4 positive regulation of gene expression GO:0010628 9.65 CD34 HRAS KRAS TP53 VIM
5 epidermal growth factor receptor signaling pathway GO:0007173 9.54 HRAS KRAS NRAS
6 heterocycle metabolic process GO:0046483 9.43 CYP2E1 UGT1A1
7 response to isolation stress GO:0035900 9.4 HRAS KRAS
8 ERBB2 signaling pathway GO:0038128 9.33 HRAS KRAS NRAS
9 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.32 WWTR1 YAP1
10 cellular response to gamma radiation GO:0071480 9.13 HRAS TP53 YAP1
11 Ras protein signal transduction GO:0007265 8.92 HRAS KRAS NRAS TP53

Sources for Liver Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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