MCID: LVR002
MIFTS: 49

Liver Angiosarcoma

Categories: Cancer diseases, Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Liver Angiosarcoma

MalaCards integrated aliases for Liver Angiosarcoma:

Name: Liver Angiosarcoma 12 15
Angiosarcoma of the Liver 76 53
Angiosarcoma of Liver 12 73
Hemangiosarcoma of the Liver 12
Hepatic Angiosarcoma 37

Classifications:



External Ids:

Disease Ontology 12 DOID:268
ICD10 33 C22.3
NCIt 50 C4438
KEGG 37 H01557
UMLS 73 C0345907

Summaries for Liver Angiosarcoma

Disease Ontology : 12 An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located in the liver.

MalaCards based summary : Liver Angiosarcoma, also known as angiosarcoma of the liver, is related to angiosarcoma and hemangioma. An important gene associated with Liver Angiosarcoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and lung, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Wikipedia : 76 Angiosarcoma is a cancer of the cells that line the walls of blood vessels or lymphatic vessels. The... more...

Related Diseases for Liver Angiosarcoma

Diseases related to Liver Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 31.1 KRAS VIM VWF
2 hemangioma 30.0 CD34 ENO2 KRAS
3 intrahepatic cholangiocarcinoma 29.9 KRAS KRT19 TP53
4 hemangioma of liver 29.8 CD34 HBA1
5 cholangiocarcinoma 29.8 KRAS KRT19 TP53 YAP1
6 brain cancer 29.3 CDK4 ENO2 HRAS NRAS TP53
7 hepatocellular carcinoma 28.9 CAMTA1 CD34 CDK4 HRAS KRAS KRT19
8 regional odontodysplasia 10.3 KRT19 VIM
9 ependymoblastoma 10.3 TP53 VIM
10 bladder carcinoma in situ 10.3 KRT19 TP53
11 astroblastoma 10.3 ENO2 VIM
12 epulis 10.3 ENO2 VIM
13 syringocystadenoma papilliferum 10.3 KRAS VIM
14 histiocytoid hemangioma 10.2 CAMTA1 HBA1
15 rare adenocarcinoma of the breast 10.2 KRAS TP53
16 aggressive digital papillary adenocarcinoma 10.2 HRAS KRAS
17 appendix disease 10.2 HRAS KRAS
18 bednar tumor 10.2 ENO2 VIM
19 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 VIM
20 hyperplastic polyposis syndrome 10.2 KRAS TP53
21 cerebral neuroblastoma 10.2 ENO2 TP53
22 malignant teratoma 10.2 ENO2 TP53
23 marcus gunn phenomenon 10.2 HRAS NRAS
24 sigmoid neoplasm 10.2 HRAS KRAS
25 adenoid squamous cell carcinoma 10.2 HBA1 VIM
26 melanomatosis 10.2 HRAS NRAS
27 papillary tumor of the pineal region 10.2 ENO2 VIM
28 deep angioma 10.2 CD34 VWF
29 kaposiform hemangioendothelioma 10.2 CD34 VWF
30 glomangiomyoma 10.2 CD34 VIM
31 apocrine adenoma 10.2 HRAS KRAS
32 sternum cancer 10.2 CD34 VIM
33 giant congenital nevus 10.2 HRAS NRAS
34 ossifying fibromyxoid tumor 10.2 ENO2 VIM
35 skin epithelioid hemangioma 10.2 CD34 HBA1
36 spindle cell lipoma 10.2 CDK4 VIM
37 periampullary adenoma 10.2 HRAS KRAS
38 ovary sarcoma 10.2 CD34 HBA1
39 ovarian angiosarcoma 10.2 CD34 HBA1
40 paronychia 10.2 HRAS KRAS
41 epithelioid leiomyosarcoma 10.2 ENO2 VIM
42 intravascular fasciitis 10.2 CD34 HBA1
43 pinguecula 10.2 CYP2E1 KRT19 TP53
44 ring chromosome 7 10.2 CDK4 TP53
45 pediatric angiosarcoma 10.2 CD34 HBA1
46 thyroid angiosarcoma 10.2 CD34 HBA1
47 plexiform schwannoma 10.2 CD34 ENO2
48 infiltrating angiolipoma 10.1 CDK4 VWF
49 benign struma ovarii 10.1 HRAS NRAS
50 bone epithelioid hemangioma 10.1 CD34 HBA1

Graphical network of the top 20 diseases related to Liver Angiosarcoma:



Diseases related to Liver Angiosarcoma

Symptoms & Phenotypes for Liver Angiosarcoma

GenomeRNAi Phenotypes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CD34 CDK4 HRAS KRAS NRAS VIM

MGI Mouse Phenotypes related to Liver Angiosarcoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 CAMTA1 CDK4 CYP2E1 ENO2 HRAS KRAS
2 cardiovascular system MP:0005385 10.29 CDK4 CYP2E1 HRAS KRAS KRT19 NRAS
3 cellular MP:0005384 10.28 CD34 CDK4 ENO2 KRAS KRT19 NRAS
4 growth/size/body region MP:0005378 10.24 CAMTA1 CDK4 ENO2 HRAS KRAS KRT19
5 homeostasis/metabolism MP:0005376 10.22 CD34 CDK4 CYP2E1 HRAS KRAS NRAS
6 digestive/alimentary MP:0005381 10.18 CDK4 HRAS KRAS KRT19 NRAS TP53
7 mortality/aging MP:0010768 10.18 CAMTA1 CDK4 CYP2E1 HRAS KRAS KRT19
8 immune system MP:0005387 10.16 CD34 CDK4 KRAS NRAS TFE3 TP53
9 endocrine/exocrine gland MP:0005379 10.11 CDK4 HRAS KRAS KRT19 NRAS TP53
10 integument MP:0010771 10.09 CD34 CDK4 HRAS KRAS KRT19 NRAS
11 neoplasm MP:0002006 10.02 CAMTA1 CD34 CDK4 CYP2E1 HRAS KRAS
12 nervous system MP:0003631 9.96 CAMTA1 CDK4 ENO2 HRAS KRAS KRT19
13 liver/biliary system MP:0005370 9.95 CDK4 CYP2E1 KRAS NRAS TP53 WWTR1
14 normal MP:0002873 9.76 CAMTA1 CDK4 HRAS KRAS KRT19 NRAS
15 pigmentation MP:0001186 9.35 CDK4 KRAS NRAS TFE3 TP53
16 respiratory system MP:0005388 9.17 ENO2 HRAS KRAS TP53 VIM WWTR1

Drugs & Therapeutics for Liver Angiosarcoma

Drugs for Liver Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification, Molecular Epidemiology Angiosarcoma of the Liver France Unknown status NCT01786889 Not Applicable
2 Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation Completed NCT03025438

Search NIH Clinical Center for Liver Angiosarcoma

Genetic Tests for Liver Angiosarcoma

Anatomical Context for Liver Angiosarcoma

MalaCards organs/tissues related to Liver Angiosarcoma:

41
Liver, Spleen, Lung, Skin, Ovary, Pancreas, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Liver Angiosarcoma:

19
The Liver

Publications for Liver Angiosarcoma

Articles related to Liver Angiosarcoma:

(show top 50) (show all 86)
# Title Authors Year
1
Mortality from liver angiosarcoma, hepatocellular carcinoma, and cirrhosis among vinyl chloride workers. ( 30474170 )
2019
2
Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013. ( 28490663 )
2017
3
Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report. ( 27718433 )
2016
4
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker. ( 27544804 )
2016
5
 Cystic angiosarcoma of the liver. A previously undescribed neoplasm. ( 26845608 )
2016
6
Surveillance for angiosarcoma of the liver among vinyl chloride workers. ( 25376416 )
2014
7
Angiosarcoma of the liver: imaging of a rare salient entity. ( 25426242 )
2014
8
Co-registered positron emission tomography/computed tomography and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging features of multiple angiosarcoma of the liver. ( 24147907 )
2014
9
Chemoembolisation combined with percutaneous radiofrequency ablation in the treatment of primary angiosarcoma of the liver. ( 23704445 )
2013
10
Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report. ( 22280556 )
2012
11
Angiosarcoma of the liver as a cause of fulminant liver failure. ( 22865805 )
2012
12
Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy. ( 21997379 )
2012
13
Widening spectrum of liver angiosarcoma in children. ( 21832953 )
2011
14
Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. ( 20546460 )
2010
15
Vinyl chloride propellant in hair spray and angiosarcoma of the liver among hairdressers and barbers: case reports. ( 19267125 )
2009
16
Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization. ( 16521200 )
2006
17
A case-cohort study of angiosarcoma of the liver and brain cancer at a polymer production plant. ( 12762079 )
2003
18
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride. ( 12211074 )
2002
19
Angiosarcoma of the liver. ( 24326660 )
2002
20
p16INK4A-alterations in primary angiosarcoma of the liver. ( 11495043 )
2001
21
Metastatic angiosarcoma of the liver preoperatively presenting as giant hemangioma. ( 11070413 )
2000
22
Establishment and characterization of a spontaneously immortalized myofibroblast cell line derived from a human liver angiosarcoma. ( 10952247 )
2000
23
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. ( 10964802 )
2000
24
Angiosarcoma of the liver presenting with esophageal bleeding and arterio-portal shunts. ( 10952255 )
2000
25
Diffuse liver angiosarcoma and cerebral cavernous angiomas in a young patient. ( 10692780 )
1999
26
Two new cases of liver angiosarcoma: history and perspectives of liver angiosarcoma among plastic industry workers. ( 9284534 )
1997
27
Epidemiologic notes and reports. Angiosarcoma of the liver among polyvinyl chloride workers--Kentucky. 1974. ( 9045039 )
1997
28
Angiosarcoma of the liver in Great Britain in proximity to vinyl chloride sites. ( 9072028 )
1997
29
Plexiform neurofibromatosis and angiosarcoma of the liver in von Recklinghausen disease. ( 9219811 )
1997
30
Angiosarcoma of the liver: MR imaging pre- and post-chemotherapy. ( 9254006 )
1997
31
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. ( 9277092 )
1996
32
Occupationally related angiosarcoma of the liver in the United Kingdom 1972-1994. ( 8977349 )
1996
33
Angiosarcoma of the liver in children. ( 8987004 )
1996
34
Angiosarcoma of the liver in Australia. ( 7854241 )
1995
35
The computed tomographic appearances of angiosarcoma of the liver. ( 8258223 )
1993
36
Abundant eosinophilic globules in a series of cases of angiosarcoma of the liver in childhood. ( 8372037 )
1993
37
Angiosarcoma of the liver in childhood: a clinicopathologic and follow-up study of 10 cases. ( 1409148 )
1992
38
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. ( 1793483 )
1991
39
Massive bleeding after fine needle aspiration of liver angiosarcoma. ( 2298353 )
1990
40
Invasive character of malignant endothelial cells in vinyl-chloride-induced liver angiosarcoma. ( 2381457 )
1990
41
Angiosarcoma of the liver mimicking cavernous hemangioma on dynamic CT. ( 2778153 )
1989
42
Liver angiosarcoma in a vinyl chloride polymerization plant worker. Report of the seventh Italian case. ( 3173221 )
1988
43
Angiosarcoma of the liver with metastasis: report of a case. ( 3443851 )
1987
44
Acute hemorrhagic pericardial effusion complicating angiosarcoma of the liver. ( 3492631 )
1987
45
Atypical diffuse angiosarcoma of the liver. ( 3577144 )
1987
46
Iatrogenic disease. Lipoid pneumonia and liver angiosarcoma. ( 3714604 )
1986
47
Infantile angiosarcoma of the liver--report of a case. ( 3454698 )
1986
48
Angiosarcoma of the liver and spleen in an infant. ( 3835556 )
1985
49
Thorium dioxide-related angiosarcoma of the liver. Pathomorphologic study of 29 autopsy cases. ( 3927870 )
1985
50
Exposure to vinyl chloride and angiosarcoma of the liver: a report of the register of cases. ( 4063218 )
1985

Variations for Liver Angiosarcoma

Expression for Liver Angiosarcoma

Search GEO for disease gene expression data for Liver Angiosarcoma.

Pathways for Liver Angiosarcoma

Pathways related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 CDK4 HRAS KRAS NRAS TP53 VWF
2
Show member pathways
12.86 CDK4 HRAS KRAS NRAS TP53
3 12.82 CDK4 HRAS KRAS NRAS TP53
4
Show member pathways
12.76 CDK4 HRAS KRAS NRAS TP53
5
Show member pathways
12.76 CDK4 HRAS KRAS NRAS TP53
6
Show member pathways
12.58 HRAS KRAS NRAS TP53 YAP1
7
Show member pathways
12.51 HRAS KRAS NRAS TP53
8 12.5 HRAS KRAS NRAS TP53 VIM
9
Show member pathways
12.49 HRAS KRAS NRAS TP53
10
Show member pathways
12.43 HRAS KRAS NRAS TP53
11
Show member pathways
12.43 HRAS KRAS NRAS TFE3 TP53
12
Show member pathways
12.42 CDK4 HRAS KRAS NRAS
13
Show member pathways
12.41 CDK4 HRAS KRAS NRAS
14
Show member pathways
12.35 CDK4 HRAS KRAS NRAS VIM
15 12.34 CDK4 HRAS KRAS NRAS TP53
16
Show member pathways
12.29 HRAS KRAS NRAS VWF
17 12.29 HRAS KRAS NRAS TP53
18
Show member pathways
12.26 HRAS KRAS NRAS TP53
19
Show member pathways
12.18 HRAS KRAS NRAS TP53
20
Show member pathways
12.15 HRAS KRAS NRAS TP53
21
Show member pathways
12.14 HRAS KRAS NRAS TP53
22
Show member pathways
12.14 CDK4 HRAS KRAS NRAS TP53
23 12.13 CDK4 HRAS KRAS NRAS TP53
24
Show member pathways
12.08 HRAS KRAS NRAS VWF
25 12.06 HRAS KRAS NRAS TP53
26
Show member pathways
12.05 HRAS KRAS NRAS TP53
27
Show member pathways
12.05 CDK4 HRAS KRAS NRAS
28 11.98 CDK4 TP53 VIM
29 11.98 HRAS KRAS NRAS TP53
30 11.96 HRAS KRAS NRAS
31 11.96 HRAS KRAS NRAS TP53
32 11.96 CDK4 HRAS KRAS NRAS TP53
33 11.95 HRAS KRAS NRAS
34 11.95 HRAS KRAS NRAS TP53
35
Show member pathways
11.91 HRAS KRAS NRAS YAP1
36
Show member pathways
11.86 HRAS KRAS NRAS
37 11.86 CDK4 HRAS KRAS NRAS TP53
38
Show member pathways
11.85 HRAS KRAS NRAS
39 11.84 HRAS KRAS NRAS
40 11.82 CDK4 HRAS KRAS NRAS
41
Show member pathways
11.8 HRAS KRAS NRAS
42
Show member pathways
11.69 HRAS KRAS NRAS
43 11.64 HRAS KRAS NRAS
44 11.61 HRAS KRAS NRAS
45 11.6 CDK4 HRAS KRAS NRAS TP53
46 11.58 HRAS KRAS NRAS TP53
47 11.53 HRAS KRAS NRAS
48 11.48 HRAS KRAS NRAS TP53
49 11.47 HRAS KRAS NRAS
50 11.35 HRAS KRAS NRAS

GO Terms for Liver Angiosarcoma

Cellular components related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 CAMTA1 CDK4 ENO2 HBA1 HRAS KRAS

Biological processes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 CAMTA1 HRAS TFE3 TP53 WWTR1 YAP1
2 positive regulation of cell proliferation GO:0008284 9.88 CDK4 HRAS KRAS WWTR1 YAP1
3 positive regulation of gene expression GO:0010628 9.72 CD34 HRAS KRAS TP53 VIM
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.63 HRAS KRAS NRAS
5 heterocycle metabolic process GO:0046483 9.43 CYP2E1 UGT1A1
6 response to isolation stress GO:0035900 9.4 HRAS KRAS
7 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.37 WWTR1 YAP1
8 cellular response to gamma radiation GO:0071480 9.33 HRAS TP53 YAP1
9 heart process GO:0003015 9.26 WWTR1 YAP1
10 tissue homeostasis GO:0001894 9.13 CD34 WWTR1 YAP1
11 Ras protein signal transduction GO:0007265 8.92 HRAS KRAS NRAS TP53

Molecular functions related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 8.92 CDK4 KRAS KRT19 NRAS

Sources for Liver Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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