MCID: LVR002
MIFTS: 42

Liver Angiosarcoma

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Liver Angiosarcoma

MalaCards integrated aliases for Liver Angiosarcoma:

Name: Liver Angiosarcoma 12 15
Angiosarcoma of the Liver 73 20
Angiosarcoma of Liver 12 70
Hemangiosarcoma of the Liver 12
Hepatic Angiosarcoma 36

Classifications:



External Ids:

Disease Ontology 12 DOID:268
KEGG 36 H01557
NCIt 50 C4438
SNOMED-CT 67 187770005
ICD10 32 C22.3
UMLS 70 C0345907

Summaries for Liver Angiosarcoma

KEGG : 36 Angiosarcoma represents 1 to 2% of soft tissue tumors. It originates from endothelial cells of small blood vessels and may affect a variety of organs, including the retroperitoneum, skeletal muscle, subcutis, liver, heart and breast. Primary hepatic angiosarcomas (HAS) are much rare tumors, with worse prognosis compared with other angiosarcomas. HAS has been found to be caused by occupational exposure to vinyl chloride (VC) monomer since 1970, and the number of VC-associated HAS cases reported up to the end of 1998 was 197 worldwide. Exposure of VC connects with a series of mechanistic events leading to carcinogenic outcome; mutations of K-ras and p53 are also detected.

MalaCards based summary : Liver Angiosarcoma, also known as angiosarcoma of the liver, is related to angiosarcoma and intrahepatic cholangiocarcinoma. An important gene associated with Liver Angiosarcoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways is Signaling mediated by p38-alpha and p38-beta. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, lung and endothelial, and related phenotypes are cardiovascular system and craniofacial

Disease Ontology : 12 An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located in the liver.

Wikipedia : 73 Angiosarcoma is a cancer of the endothelial cells that line the walls of blood vessels or lymphatic... more...

Related Diseases for Liver Angiosarcoma

Diseases related to Liver Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 30.3 VIM TP53 PECAM1 KRAS
2 intrahepatic cholangiocarcinoma 30.3 TP53 KRT19 KRAS
3 cholangiocarcinoma 30.3 TP53 KRT19 KRAS
4 benign mesothelioma 29.8 VIM PECAM1 KRT19
5 pediatric angiosarcoma 29.8 TP53 PECAM1
6 mesenchymal cell neoplasm 29.7 TP53 PECAM1
7 hemangiopericytoma, malignant 29.7 VIM PECAM1
8 cavernous hemangioma 29.6 VIM PECAM1 KRT19
9 hepatoblastoma 29.5 TP53 KRT19 CYP2E1
10 hemangioma 29.5 VIM TP53 PECAM1 KRAS
11 renal cell carcinoma, nonpapillary 29.1 VIM TP53 PECAM1 KRT19
12 syringocystadenoma papilliferum 10.3 KRT19 KRAS
13 pancreatic acinar cell adenocarcinoma 10.3 KRT19 KRAS
14 regional odontodysplasia 10.3 VIM KRT19
15 bile duct cysts 10.3 KRT19 KRAS
16 struma ovarii 10.3 KRT19 KRAS
17 odontoma 10.3 VIM KRT19
18 pericardial mesothelioma 10.3 VIM KRT19
19 eccrine papillary adenoma 10.3 KRT19 KRAS
20 eccrine porocarcinoma 10.3 VIM KRT19
21 rare tumor 10.2
22 monophasic synovial sarcoma 10.2 VIM KRT19
23 syringoma 10.2 VIM KRT19
24 epithelioid hemangioendothelioma 10.2
25 pancreatic signet ring cell adenocarcinoma 10.2 TP53 KRAS
26 signet ring cell adenocarcinoma 10.2 TP53 KRAS
27 bone giant cell sarcoma 10.2 TP53 KRAS
28 nephroma 10.2 VIM KRT19
29 malignant exocrine pancreas neoplasm 10.2 TP53 KRAS
30 eccrine sweat gland cancer 10.2 TP53 KRT19
31 sweat gland cancer 10.2 TP53 KRT19
32 appendix disease 10.2 TP53 KRAS
33 pediatric liposarcoma 10.2 VIM TP53
34 endometrioid ovary carcinoma 10.2 TP53 KRAS
35 appendix cancer 10.2 TP53 KRAS
36 clear cell basal cell carcinoma 10.2 TP53 KRT19
37 large intestine adenocarcinoma 10.2 TP53 KRAS
38 nasal cavity adenocarcinoma 10.2 TP53 KRAS
39 disseminated intravascular coagulation 10.2
40 endometrial serous adenocarcinoma 10.1 TP53 KRAS
41 intrahepatic bile duct adenoma 10.1 TP53 KRT19
42 embryonal sarcoma 10.1 VIM TP53
43 klatskin's tumor 10.1 TP53 KRT19
44 female reproductive endometrioid cancer 10.1 TP53 KRAS
45 anus cancer 10.1 TP53 KRAS
46 duodenum cancer 10.1 TP53 KRAS
47 duodenum disease 10.1 TP53 KRAS
48 granulosa cell tumor of the ovary 10.1 VIM TP53
49 skin papilloma 10.1 TP53 KRAS
50 spiradenoma 10.1 VIM TP53

Graphical network of the top 20 diseases related to Liver Angiosarcoma:



Diseases related to Liver Angiosarcoma

Symptoms & Phenotypes for Liver Angiosarcoma

MGI Mouse Phenotypes related to Liver Angiosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 CYP2E1 KRAS KRT19 PECAM1 SKI SNRK
2 craniofacial MP:0005382 9.65 CYP2E1 KRAS KRT19 SKI TP53
3 liver/biliary system MP:0005370 9.63 CYP2E1 KRAS KRT19 PECAM1 SNRK TP53
4 muscle MP:0005369 9.43 KRAS PECAM1 SKI SNRK TP53 VIM
5 neoplasm MP:0002006 9.02 CYP2E1 KRAS KRT19 SKI TP53

Drugs & Therapeutics for Liver Angiosarcoma

Drugs for Liver Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification, Molecular Epidemiology Angiosarcoma of the Liver France Unknown status NCT01786889
2 Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation Completed NCT03025438

Search NIH Clinical Center for Liver Angiosarcoma

Genetic Tests for Liver Angiosarcoma

Anatomical Context for Liver Angiosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Liver Angiosarcoma:

19
Liver

MalaCards organs/tissues related to Liver Angiosarcoma:

40
Liver, Lung, Endothelial, Skeletal Muscle, Breast, Skin, Heart

Publications for Liver Angiosarcoma

Articles related to Liver Angiosarcoma:

(show top 50) (show all 229)
# Title Authors PMID Year
1
Hepatic angiosarcoma in an adult who had Wilms tumor treated in childhood: A case report. 61
33747329 2021
2
[Giant liver angiosarcoma]. 61
32841142 2020
3
Chemical Risk Factors of Primary Liver Cancer: An Update. 61
33447099 2020
4
Somatic mutation signatures in primary liver tumors of workers exposed to ionizing radiation. 61
31796844 2019
5
Sinusoidal-type Angiosarcoma of the Liver: Imaging Features and Potential Diagnostic Utility of p53 Immunostaining. 61
31425166 2019
6
Occupational exposure to vinyl chloride and liver diseases. 61
31543680 2019
7
Induction of Fibrosis and Autophagy in Kidney Cells by Vinyl Chloride. 61
31212930 2019
8
Angiosarcoma of the Liver: Clinicopathologic Features and Morphologic Patterns. 61
30986799 2019
9
Mortality from liver angiosarcoma, hepatocellular carcinoma, and cirrhosis among vinyl chloride workers. 61
30474170 2019
10
Monsanto, PCBs, and the creation of a "world-wide ecological problem". 61
30401808 2018
11
A pooled analysis of treatment and prognosis of hepatic angiosarcoma in adults. 61
29724676 2018
12
Epithelioid angiosarcoma of the liver: report of two cases and review of the literature. 61
31938449 2018
13
Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013. 61
28490663 2017
14
The lymphocyte cytokinesis block micronucleus test in human populations occupationally exposed to vinyl chloride: A systematic review and meta-analysis. 61
29173494 2017
15
Unusual Indications for a Liver Transplant: A Single-Center Experience. 61
28260452 2017
16
Data quality in rare cancers registration: the report of the RARECARE data quality study. 61
27716878 2017
17
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker. 61
27544804 2016
18
 Cystic angiosarcoma of the liver. A previously undescribed neoplasm. 61
26845608 2016
19
Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report. 61
27718433 2016
20
Assessment of emergency responders after a vinyl chloride release from a train derailment - New Jersey, 2012. 61
25577988 2015
21
Surveillance for angiosarcoma of the liver among vinyl chloride workers. 61
25376416 2014
22
Co-registered positron emission tomography/computed tomography and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging features of multiple angiosarcoma of the liver. 61
24147907 2014
23
Angiosarcoma of the liver: imaging of a rare salient entity. 61
25426242 2014
24
Non-healing Scalp Ulcer Accompanying Chronic Arsenicosis: A Case Report. 61
24995232 2014
25
Chemoembolisation combined with percutaneous radiofrequency ablation in the treatment of primary angiosarcoma of the liver. 61
23704445 2013
26
[Liver angiosarcoma from past exposure to vinyl chloride: a case report]. 61
23405480 2012
27
Epithelioid angiosarcoma metastases to the bone marrow manifesting as erythroblastic anemia and leukocytosis: a case report and review of the literature. 61
23161238 2012
28
Risk of hepatocellular carcinoma in workers exposed to chemicals. 61
23162599 2012
29
Angiosarcoma of the liver as a cause of fulminant liver failure. 61
22865805 2012
30
[Idiopathic hepatic angiosarcoma. A case report]. 61
23234750 2012
31
Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy. 61
21997379 2012
32
Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report. 61
22280556 2012
33
Widening spectrum of liver angiosarcoma in children. 61
21832953 2011
34
Vinyl chloride industry in the courtroom and corporate influences on the scientific literature. 61
21456080 2011
35
Angiosarcoma in a patient with immunodeficiency, centromeric region instability, facial anomalies (ICF) syndrome. 61
21337690 2011
36
Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N(2),3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC. 61
20799743 2010
37
Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. 61
20546460 2010
38
Vinyl chloride and the liver. 61
19836850 2009
39
[Primary angiosarcoma of the liver]. 61
19581774 2009
40
A strange Evans syndrome: a case report. 61
19830043 2009
41
Vinyl chloride propellant in hair spray and angiosarcoma of the liver among hairdressers and barbers: case reports. 61
19267125 2009
42
Occupational exposure to vinyl chloride and risk of hepatocellular carcinoma. 61
18560983 2008
43
[Adult-onset Still's disease and hepatic angiosarcoma, a fortuitous association or a paraneoplastic syndrome: a case-report]. 61
18572281 2008
44
[Angiosarcoma of the liver as a rare cause of rapidly progressive liver failure]. 61
16977400 2006
45
Multiple cutaneous infantile hemangiomas associated with hepatic angiosarcoma: case report and review of the literature. 61
16880251 2006
46
Mortality rates among chemical workers in the Kanawha Valley of West Virginia: 1940-1999. 61
17111678 2006
47
Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization. 61
16521200 2006
48
Molecular mechanisms of carcinogenesis by vinyl chloride. 61
17033136 2006
49
[Operative-technical special features of the left lobectomy in colorectal cancer liver metastases]. 61
18846691 2006
50
A cancer incidence and mortality study of Dow Chemical Canada Inc. manufacturing sites. 61
16174663 2005

Variations for Liver Angiosarcoma

Cosmic variations for Liver Angiosarcoma:

9 (show top 50) (show all 1328)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM94290791 XIAP soft tissue,blood vessel,angiosarcoma,NS c.73G>C p.E25Q 23:123885735-123885735 6
2 COSM92181036 XIAP soft tissue,blood vessel,angiosarcoma,NS c.73G>C p.E25Q 23:123885735-123885735 6
3 COSM108084128 XIAP soft tissue,blood vessel,angiosarcoma,NS c.73G>C p.E25Q 23:123885735-123885735 6
4 COSM91383022 WT1 soft tissue,blood vessel,angiosarcoma,NS c.983G>A p.W328* 11:32416508-32416508 6
5 COSM148593299 WT1 soft tissue,blood vessel,angiosarcoma,NS c.983G>A p.W328* 11:32416508-32416508 6
6 COSM100781781 WT1 soft tissue,blood vessel,angiosarcoma,NS c.347G>A p.W116* 11:32416508-32416508 6
7 COSM149739973 WT1 soft tissue,blood vessel,angiosarcoma,NS c.983G>A p.W328* 11:32416508-32416508 6
8 COSM130518667 WT1 soft tissue,blood vessel,angiosarcoma,NS c.314+1069G>A p.? 11:32416508-32416508 6
9 COSM113485009 WT1 soft tissue,blood vessel,angiosarcoma,NS c.983G>A p.W328* 11:32416508-32416508 6
10 COSM111539054 WT1 soft tissue,blood vessel,angiosarcoma,NS c.950+1069G>A p.? 11:32416508-32416508 6
11 COSM147426307 WT1 soft tissue,blood vessel,angiosarcoma,NS c.950+1069G>A p.? 11:32416508-32416508 6
12 COSM149814991 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
13 COSM151514404 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4510C>T p.R1504W 16:2085245-2085245 6
14 COSM150365953 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
15 COSM151378978 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
16 COSM151755621 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
17 COSM150324884 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
18 COSM150315618 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4384C>T p.R1462W 16:2085245-2085245 6
19 COSM102634843 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
20 COSM148983289 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4387C>T p.R1463W 16:2085245-2085245 6
21 COSM101196039 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2347C>G p.H783D 16:2074338-2074338 6
22 COSM136629025 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1106G>A p.W369* 16:2060767-2060767 6
23 COSM87041278 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
24 COSM148996186 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
25 COSM150586941 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
26 COSM147712334 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
27 COSM110114858 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.962G>A p.W321* 16:2060767-2060767 6
28 COSM136619132 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4417C>T p.R1473W 16:2085245-2085245 6
29 COSM90415849 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
30 COSM151518304 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
31 COSM110120269 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2383C>G p.H795D 16:2074338-2074338 6
32 COSM149803740 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4453C>T p.R1485W 16:2085245-2085245 6
33 COSM150369517 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
34 COSM150584116 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
35 COSM110105462 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4276C>T p.R1426W 16:2085245-2085245 6
36 COSM90421077 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
37 COSM151371641 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4579C>T p.R1527W 16:2085245-2085245 6
38 COSM151519993 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
39 COSM149820498 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
40 COSM87029815 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4585C>T p.R1529W 16:2085245-2085245 6
41 COSM151748696 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4456C>T p.R1486W 16:2085245-2085245 6
42 COSM101192082 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.926G>A p.W309* 16:2060767-2060767 6
43 COSM102630453 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
44 COSM148992188 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
45 COSM147707387 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
46 COSM151376817 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
47 COSM87046601 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.2494C>G p.H832D 16:2074338-2074338 6
48 COSM147694585 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4456C>T p.R1486W 16:2085245-2085245 6
49 COSM151753419 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.1073G>A p.W358* 16:2060767-2060767 6
50 COSM101182298 TSC2 soft tissue,blood vessel,angiosarcoma,NS c.4240C>T p.R1414W 16:2085245-2085245 6

Expression for Liver Angiosarcoma

Search GEO for disease gene expression data for Liver Angiosarcoma.

Pathways for Liver Angiosarcoma

Pathways related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.17 TP53 KRT19

GO Terms for Liver Angiosarcoma

Biological processes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of fibroblast proliferation GO:0048147 8.62 TP53 SKI

Sources for Liver Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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