MCID: LVR002
MIFTS: 48

Liver Angiosarcoma

Categories: Cancer diseases, Cardiovascular diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases, Rare diseases

Aliases & Classifications for Liver Angiosarcoma

MalaCards integrated aliases for Liver Angiosarcoma:

Name: Liver Angiosarcoma 12 15
Angiosarcoma of the Liver 77 54
Angiosarcoma of Liver 12 74
Hemangiosarcoma of the Liver 12
Hepatic Angiosarcoma 38

Classifications:



External Ids:

Disease Ontology 12 DOID:268
KEGG 38 H01557
NCIt 51 C4438
ICD10 34 C22.3
UMLS 74 C0345907

Summaries for Liver Angiosarcoma

Disease Ontology : 12 An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located in the liver.

MalaCards based summary : Liver Angiosarcoma, also known as angiosarcoma of the liver, is related to angiosarcoma and hemangioendothelioma. An important gene associated with Liver Angiosarcoma is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, brain and spleen, and related phenotypes are Reduced mammosphere formation and cellular

Wikipedia : 77 Angiosarcoma is a cancer of the cells that line the walls of blood vessels or lymphatic vessels. The... more...

Related Diseases for Liver Angiosarcoma

Diseases related to Liver Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 31.0 KRAS PECAM1 VIM VWF
2 hemangioendothelioma 30.4 CAMTA1 PECAM1
3 cholangiocarcinoma 30.2 KRAS KRT19 TP53 YAP1
4 intrahepatic cholangiocarcinoma 30.0 KRAS KRT19 TP53
5 hemangioma 29.8 CD34 ENO2 KRAS PECAM1
6 brain cancer 29.2 CDK4 ENO2 HRAS NRAS TP53
7 hepatocellular carcinoma 28.4 CAMTA1 CD34 CDK4 HRAS KRAS KRT19
8 regional odontodysplasia 10.5 KRT19 VIM
9 syringocystadenoma papilliferum 10.4 KRAS VIM
10 sigmoid neoplasm 10.4 HRAS KRAS
11 apocrine adenoma 10.4 HRAS KRAS
12 melanomatosis 10.4 HRAS NRAS
13 epulis 10.4 ENO2 VIM
14 periampullary adenoma 10.4 HRAS KRAS
15 paronychia 10.4 HRAS KRAS
16 rare adenocarcinoma of the breast 10.4 KRAS TP53
17 giant congenital nevus 10.4 HRAS NRAS
18 hyperplastic polyposis syndrome 10.4 KRAS TP53
19 bednar tumor 10.3 ENO2 VIM
20 primitive neuroectodermal tumor of the cervix uteri 10.3 ENO2 VIM
21 bile duct cysts 10.3 HRAS KRAS
22 papillary tumor of the pineal region 10.3 ENO2 VIM
23 benign struma ovarii 10.3 HRAS NRAS
24 ossifying fibromyxoid tumor 10.3 ENO2 VIM
25 anal canal adenocarcinoma 10.3 HRAS KRAS KRT19
26 epithelioid leiomyosarcoma 10.3 ENO2 VIM
27 colloid carcinoma of the pancreas 10.3 HRAS KRAS KRT19
28 spindle cell lipoma 10.3 CDK4 VIM
29 ovarian melanoma 10.3 HRAS NRAS
30 glomangiomyoma 10.3 CD34 VIM
31 mutyh-associated polyposis 10.3 KRAS TP53
32 sternum cancer 10.3 CD34 VIM
33 aggressive digital papillary adenocarcinoma 10.3 HRAS KRAS
34 clear cell ependymoma 10.3 ENO2 VIM
35 infiltrating angiolipoma 10.3 CDK4 VWF
36 malignant conjunctival melanoma 10.3 HRAS NRAS
37 malignant ectomesenchymoma 10.3 ENO2 HRAS
38 ectomesenchymoma 10.3 ENO2 HRAS
39 schimmelpenning-feuerstein-mims syndrome 10.3 HRAS KRAS NRAS
40 pinguecula 10.2 CYP2E1 KRT19 TP53
41 spleen angiosarcoma 10.2 CD34 VWF
42 acneiform dermatitis 10.2 HRAS KRAS NRAS
43 ring chromosome 7 10.2 CDK4 TP53
44 pericardial mesothelioma 10.2 ENO2 KRT19 VIM
45 spitz nevus 10.2 HRAS TP53
46 core binding factor acute myeloid leukemia 10.2 HRAS KRAS NRAS
47 malignant struma ovarii 10.2 HRAS KRT19 NRAS
48 bladder carcinoma in situ 10.2 KRT19 TP53
49 nevus, epidermal 10.2 HRAS KRAS NRAS
50 nasal cavity adenocarcinoma 10.2 HRAS KRAS TP53

Graphical network of the top 20 diseases related to Liver Angiosarcoma:



Diseases related to Liver Angiosarcoma

Symptoms & Phenotypes for Liver Angiosarcoma

GenomeRNAi Phenotypes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CD34 CDK4 HRAS KRAS MCM3 NRAS

MGI Mouse Phenotypes related to Liver Angiosarcoma:

47 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 CD34 CDK4 ENO2 KRAS KRT19 MCM3
2 cardiovascular system MP:0005385 10.37 CDK4 CYP2E1 HRAS KRAS KRT19 NRAS
3 behavior/neurological MP:0005386 10.34 CAMTA1 CDK4 CYP2E1 ENO2 HRAS KRAS
4 homeostasis/metabolism MP:0005376 10.34 CD34 CDK4 CYP2E1 HRAS KRAS MCM3
5 growth/size/body region MP:0005378 10.33 CAMTA1 CDK4 ENO2 HRAS KRAS KRT19
6 mortality/aging MP:0010768 10.3 CAMTA1 CDK4 CYP2E1 HRAS KRAS KRT19
7 digestive/alimentary MP:0005381 10.27 CDK4 HRAS KRAS KRT19 NRAS PECAM1
8 immune system MP:0005387 10.25 CD34 CDK4 KRAS NRAS PECAM1 TFE3
9 hematopoietic system MP:0005397 10.24 CD34 CDK4 KRAS MCM3 NRAS PECAM1
10 endocrine/exocrine gland MP:0005379 10.21 CDK4 HRAS KRAS KRT19 MCM3 NRAS
11 integument MP:0010771 10.19 CD34 CDK4 HRAS KRAS KRT19 MCM3
12 embryo MP:0005380 10.17 CDK4 KRAS KRT19 MCM3 NRAS TP53
13 neoplasm MP:0002006 10.14 CAMTA1 CD34 CDK4 CYP2E1 HRAS KRAS
14 liver/biliary system MP:0005370 10.13 CDK4 CYP2E1 KRAS MCM3 NRAS PECAM1
15 nervous system MP:0003631 10.07 CAMTA1 CDK4 ENO2 HRAS KRAS KRT19
16 muscle MP:0005369 9.98 CDK4 KRAS PECAM1 TP53 VIM WWTR1
17 normal MP:0002873 9.92 CAMTA1 CDK4 HRAS KRAS KRT19 NRAS
18 renal/urinary system MP:0005367 9.7 CDK4 HRAS KRAS PECAM1 TP53 WWTR1
19 pigmentation MP:0001186 9.65 CDK4 KRAS NRAS TFE3 TP53
20 respiratory system MP:0005388 9.56 ENO2 HRAS KRAS PECAM1 TP53 VIM
21 skeleton MP:0005390 9.23 HRAS KRAS KRT19 NRAS PECAM1 TFE3

Drugs & Therapeutics for Liver Angiosarcoma

Drugs for Liver Angiosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification, Molecular Epidemiology Angiosarcoma of the Liver France Unknown status NCT01786889 Not Applicable
2 Cytological Diagnosis of Hepatic Angiosarcoma and Its Histopathologic Correlation Completed NCT03025438

Search NIH Clinical Center for Liver Angiosarcoma

Genetic Tests for Liver Angiosarcoma

Anatomical Context for Liver Angiosarcoma

MalaCards organs/tissues related to Liver Angiosarcoma:

42
Liver, Brain, Spleen, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Liver Angiosarcoma:

20
The Liver

Publications for Liver Angiosarcoma

Articles related to Liver Angiosarcoma:

(show top 50) (show all 86)
# Title Authors Year
1
Mortality from liver angiosarcoma, hepatocellular carcinoma, and cirrhosis among vinyl chloride workers. ( 30474170 )
2018
2
Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013. ( 28490663 )
2017
3
Liver Angiosarcoma: Rare tumour associated with a poor prognosis, literature review and case report. ( 27718433 )
2016
4
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride-exposed worker. ( 27544804 )
2016
5
 Cystic angiosarcoma of the liver. A previously undescribed neoplasm. ( 26845608 )
2016
6
Surveillance for angiosarcoma of the liver among vinyl chloride workers. ( 25376416 )
2014
7
Angiosarcoma of the liver: imaging of a rare salient entity. ( 25426242 )
2014
8
Co-registered positron emission tomography/computed tomography and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging features of multiple angiosarcoma of the liver. ( 24147907 )
2014
9
Chemoembolisation combined with percutaneous radiofrequency ablation in the treatment of primary angiosarcoma of the liver. ( 23704445 )
2013
10
Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture--a case report. ( 22280556 )
2012
11
Angiosarcoma of the liver as a cause of fulminant liver failure. ( 22865805 )
2012
12
Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy. ( 21997379 )
2012
13
Widening spectrum of liver angiosarcoma in children. ( 21832953 )
2011
14
Education and Imaging. Hepatobiliary and pancreatic: angiosarcoma of the liver. ( 20546460 )
2010
15
Vinyl chloride propellant in hair spray and angiosarcoma of the liver among hairdressers and barbers: case reports. ( 19267125 )
2009
16
Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization. ( 16521200 )
2006
17
A case-cohort study of angiosarcoma of the liver and brain cancer at a polymer production plant. ( 12762079 )
2003
18
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride. ( 12211074 )
2002
19
Angiosarcoma of the liver. ( 24326660 )
2002
20
p16INK4A-alterations in primary angiosarcoma of the liver. ( 11495043 )
2001
21
Metastatic angiosarcoma of the liver preoperatively presenting as giant hemangioma. ( 11070413 )
2000
22
Establishment and characterization of a spontaneously immortalized myofibroblast cell line derived from a human liver angiosarcoma. ( 10952247 )
2000
23
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. ( 10964802 )
2000
24
Angiosarcoma of the liver presenting with esophageal bleeding and arterio-portal shunts. ( 10952255 )
2000
25
Diffuse liver angiosarcoma and cerebral cavernous angiomas in a young patient. ( 10692780 )
1999
26
Two new cases of liver angiosarcoma: history and perspectives of liver angiosarcoma among plastic industry workers. ( 9284534 )
1997
27
Plexiform neurofibromatosis and angiosarcoma of the liver in von Recklinghausen disease. ( 9219811 )
1997
28
Epidemiologic notes and reports. Angiosarcoma of the liver among polyvinyl chloride workers--Kentucky. 1974. ( 9045039 )
1997
29
Angiosarcoma of the liver in Great Britain in proximity to vinyl chloride sites. ( 9072028 )
1997
30
Angiosarcoma of the liver: MR imaging pre- and post-chemotherapy. ( 9254006 )
1997
31
Vinylchloride monomer exposure by the plastic industry workers basic condition for liver angiosarcoma appearance. ( 9277092 )
1996
32
Occupationally related angiosarcoma of the liver in the United Kingdom 1972-1994. ( 8977349 )
1996
33
Angiosarcoma of the liver in children. ( 8987004 )
1996
34
Angiosarcoma of the liver in Australia. ( 7854241 )
1995
35
The computed tomographic appearances of angiosarcoma of the liver. ( 8258223 )
1993
36
Abundant eosinophilic globules in a series of cases of angiosarcoma of the liver in childhood. ( 8372037 )
1993
37
Angiosarcoma of the liver in childhood: a clinicopathologic and follow-up study of 10 cases. ( 1409148 )
1992
38
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure. ( 1793483 )
1991
39
Massive bleeding after fine needle aspiration of liver angiosarcoma. ( 2298353 )
1990
40
Invasive character of malignant endothelial cells in vinyl-chloride-induced liver angiosarcoma. ( 2381457 )
1990
41
Angiosarcoma of the liver mimicking cavernous hemangioma on dynamic CT. ( 2778153 )
1989
42
Liver angiosarcoma in a vinyl chloride polymerization plant worker. Report of the seventh Italian case. ( 3173221 )
1988
43
Angiosarcoma of the liver with metastasis: report of a case. ( 3443851 )
1987
44
Acute hemorrhagic pericardial effusion complicating angiosarcoma of the liver. ( 3492631 )
1987
45
Atypical diffuse angiosarcoma of the liver. ( 3577144 )
1987
46
Iatrogenic disease. Lipoid pneumonia and liver angiosarcoma. ( 3714604 )
1986
47
Infantile angiosarcoma of the liver--report of a case. ( 3454698 )
1986
48
Thorium dioxide-related angiosarcoma of the liver. Pathomorphologic study of 29 autopsy cases. ( 3927870 )
1985
49
Exposure to vinyl chloride and angiosarcoma of the liver: a report of the register of cases. ( 4063218 )
1985
50
Angiosarcoma of the liver and spleen in an infant. ( 3835556 )
1985

Variations for Liver Angiosarcoma

Expression for Liver Angiosarcoma

Search GEO for disease gene expression data for Liver Angiosarcoma.

Pathways for Liver Angiosarcoma

Pathways related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 CDK4 HRAS KRAS NRAS TP53 VWF
2
Show member pathways
12.85 CDK4 HRAS KRAS NRAS TP53
3 12.82 CDK4 HRAS KRAS NRAS TP53
4
Show member pathways
12.75 CDK4 HRAS KRAS NRAS TP53
5
Show member pathways
12.69 CDK4 HRAS KRAS NRAS TP53
6
Show member pathways
12.58 HRAS KRAS NRAS TP53 YAP1
7
Show member pathways
12.54 HRAS KRAS NRAS TFE3 TP53
8 12.5 HRAS KRAS NRAS TP53 VIM
9 12.49 CDK4 MCM3 TP53 VIM
10
Show member pathways
12.48 HRAS KRAS NRAS TP53
11
Show member pathways
12.43 HRAS KRAS NRAS TP53
12
Show member pathways
12.41 CDK4 HRAS KRAS NRAS
13
Show member pathways
12.35 CDK4 HRAS KRAS NRAS VIM
14 12.29 HRAS KRAS NRAS TP53
15 12.27 CDK4 HRAS KRAS NRAS TP53
16
Show member pathways
12.25 HRAS KRAS NRAS TP53
17
Show member pathways
12.23 HRAS KRAS NRAS PECAM1
18
Show member pathways
12.17 HRAS KRAS NRAS TP53
19
Show member pathways
12.14 HRAS KRAS NRAS TP53
20
Show member pathways
12.14 CDK4 HRAS KRAS NRAS TP53
21
Show member pathways
12.13 HRAS KRAS NRAS TP53
22 12.13 CDK4 HRAS KRAS NRAS TP53
23
Show member pathways
12.08 HRAS KRAS NRAS VWF
24
Show member pathways
12.05 CDK4 HRAS KRAS NRAS
25
Show member pathways
12.04 HRAS KRAS NRAS TP53
26 11.99 HRAS KRAS NRAS TP53
27 11.98 CDK4 TP53 VIM
28 11.96 HRAS KRAS NRAS
29 11.96 HRAS KRAS NRAS TP53
30 11.96 CDK4 HRAS KRAS NRAS TP53
31 11.95 HRAS KRAS NRAS
32 11.95 HRAS KRAS NRAS TP53
33
Show member pathways
11.91 HRAS KRAS NRAS YAP1
34 11.86 CDK4 HRAS KRAS NRAS TP53
35
Show member pathways
11.85 HRAS KRAS NRAS
36 11.83 CDK4 MCM3 TP53
37 11.83 CDK4 HRAS KRAS NRAS
38
Show member pathways
11.8 HRAS KRAS NRAS
39
Show member pathways
11.68 HRAS KRAS NRAS
40 11.64 HRAS KRAS NRAS
41 11.61 HRAS KRAS NRAS
42 11.6 CDK4 HRAS KRAS NRAS TP53
43 11.58 HRAS KRAS NRAS TP53
44 11.53 HRAS KRAS NRAS
45 11.48 HRAS KRAS NRAS TP53
46 11.47 HRAS KRAS NRAS
47 11.35 HRAS KRAS NRAS
48 11.28 HRAS KRAS NRAS
49 11.27 HRAS KRAS NRAS
50
Show member pathways
11.24 HRAS KRAS NRAS

GO Terms for Liver Angiosarcoma

Cellular components related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.9 CAMTA1 CDK4 ENO2 HRAS KRAS KRT19
2 cytoplasm GO:0005737 9.77 CAMTA1 CD34 CDK4 CYP2E1 ENO2 HRAS
3 cell periphery GO:0071944 8.8 CD34 KRT19 PECAM1

Biological processes related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 CAMTA1 HRAS TFE3 TP53 WWTR1 YAP1
2 positive regulation of cell proliferation GO:0008284 9.88 CDK4 HRAS KRAS WWTR1 YAP1
3 positive regulation of gene expression GO:0010628 9.77 CD34 HRAS KRAS TP53 VIM
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.63 HRAS KRAS NRAS
5 response to isolation stress GO:0035900 9.43 HRAS KRAS
6 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.4 WWTR1 YAP1
7 cellular response to gamma radiation GO:0071480 9.33 HRAS TP53 YAP1
8 heart process GO:0003015 9.32 WWTR1 YAP1
9 glomerular endothelium development GO:0072011 9.26 CD34 PECAM1
10 tissue homeostasis GO:0001894 9.13 CD34 WWTR1 YAP1
11 Ras protein signal transduction GO:0007265 8.92 HRAS KRAS NRAS TP53

Molecular functions related to Liver Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.26 CDK4 KRAS KRT19 NRAS
2 nucleotide binding GO:0000166 9.02 CDK4 HRAS KRAS MCM3 NRAS

Sources for Liver Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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