MCID: LVR031
MIFTS: 28

Liver Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Liver Benign Neoplasm

MalaCards integrated aliases for Liver Benign Neoplasm:

Name: Liver Benign Neoplasm 12 15
Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:916
NCIt 50 C7103 C7106
ICD10 32 D13.4
UMLS 70 C1333419 C1333976

Summaries for Liver Benign Neoplasm

MalaCards based summary : Liver Benign Neoplasm, also known as epithelial hepatic and intrahepatic bile duct neoplasm, is related to hepatocellular adenoma and liver sarcoma. An important gene associated with Liver Benign Neoplasm is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Pathways in cancer and Translation Non-genomic (rapid) action of Androgen Receptor. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Liver Benign Neoplasm

Diseases related to Liver Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 hepatocellular adenoma 30.7 SLC37A4 IL6ST HNF1A GSTP1 GPC3 GLUL
2 liver sarcoma 11.5
3 liver adenomatosis 10.4 HNF1A CTNNB1
4 extragonadal nonseminomatous germ cell tumor 10.4 G6PC1 AFP
5 ovarian embryonal carcinoma 10.4 GPC3 AFP
6 acute vascular insufficiency of intestine 10.4 GOT2 FABP1
7 ovarian primitive germ cell tumor 10.4 GPC3 AFP
8 ovarian endodermal sinus tumor 10.4 GPC3 AFP
9 vulvar intraepithelial neoplasia 10.4 TP53 CTNNB1
10 glycogen storage disease due to glucose-6-phosphatase deficiency 10.4 SLC37A4 G6PC1
11 hyper-ige recurrent infection syndrome 1, autosomal dominant 10.4 STAT3 IL6ST
12 testicular malignant germ cell cancer 10.3 GPC3 AFP
13 sclerosing hepatic carcinoma 10.3 GPC3 AFP
14 adult teratoma 10.3 TP53 AFP
15 gallbladder adenoma 10.3 PPARA CTNNB1
16 non-gestational ovarian choriocarcinoma 10.3 TP53 AFP
17 hematocele of tunica vaginalis testis 10.3 GOT2 GLUL AFP
18 simpson-golabi-behmel syndrome 10.3 GPC3 CTNNB1
19 intratubular embryonal carcinoma 10.3 TP53 AFP
20 glycogen storage disease ia 10.3 SLC37A4 HNF1A G6PC1
21 peliosis hepatis 10.3 GLUL AFP
22 embryonal sarcoma 10.3 TP53 GPC3 CTNNB1
23 mammary analogue secretory carcinoma 10.3 TP53 CTNNB1
24 sarcomatous intrahepatic cholangiocarcinoma 10.3 GPC3 AFP
25 mixed cell type cancer 10.3 TP53 CTNNB1 AFP
26 acinar cell carcinoma 10.3 TP53 CTNNB1 AFP
27 bone squamous cell carcinoma 10.3 TP53 STAT3 CTNNB1
28 hepatic tuberculosis 10.3 HNF1A GLUL FABP1 AFP
29 reproductive organ benign neoplasm 10.3 TP53 CTNNB1 AFP
30 biliary tract benign neoplasm 10.3 TP53 AFP
31 cardiovascular organ benign neoplasm 10.2 TP53 CTNNB1 AFP
32 colonic benign neoplasm 10.2 TP53 STAT3 CTNNB1
33 fibrolamellar carcinoma 10.2 GPC3 GLUL CTNNB1 AFP
34 ovarian gonadoblastoma 10.2 GPC3 AFP
35 ureteral obstruction 10.2 TP53 FABP1 CTNNB1
36 breast carcinoma in situ 10.2 TP53 IL6ST CTNNB1
37 human papillomavirus infectious disease 10.2 TP53 TERT
38 acute porphyria 10.2 NR1I3 NR1I2 GLUL
39 lymphangioma 10.2 TP53 STAT3 CTNNB1
40 intestinal benign neoplasm 10.2 TP53 STAT3 CTNNB1
41 inherited bone marrow failure syndromes 10.2 TERT SLC37A4
42 intrahepatic bile duct adenoma 10.2 TP53 HNF1A CTNNB1 AFP
43 suppression of tumorigenicity 12 10.2 TP53 GSTP1 CTNNB1
44 vaginal adenoma 10.2 CYP1A1 CTNNB1
45 tongue disease 10.2 TP53 STAT3 CTNNB1
46 glycogen storage disease 10.2 SLC37A4 HNF1A G6PC1 AFP
47 urinary tract papillary transitional cell benign neoplasm 10.2 TP53 TERT
48 gastrointestinal system benign neoplasm 10.2 TP53 STAT3 HNF1A CTNNB1
49 bladder papillary transitional cell neoplasm 10.2 TP53 TERT
50 colorectal adenoma 10.2 TP53 GSTP1 CTNNB1

Graphical network of the top 20 diseases related to Liver Benign Neoplasm:



Diseases related to Liver Benign Neoplasm

Symptoms & Phenotypes for Liver Benign Neoplasm

MGI Mouse Phenotypes related to Liver Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.32 AFP CTNNB1 CYP1A1 FABP1 FRK G6PC1
2 cellular MP:0005384 10.25 CTNNB1 G6PC1 GLUL GPC3 HNF1A IL6ST
3 growth/size/body region MP:0005378 10.25 CTNNB1 CYP1A1 G6PC1 GLUL GPC3 GSTP1
4 liver/biliary system MP:0005370 10.2 AFP CTNNB1 CYP1A1 FABP1 G6PC1 GLUL
5 mortality/aging MP:0010768 10.16 AFP CTNNB1 CYP1A1 G6PC1 GLUL GOT2
6 neoplasm MP:0002006 9.81 AFP CTNNB1 FRK G6PC1 GSTP1 IL6ST
7 renal/urinary system MP:0005367 9.56 CTNNB1 G6PC1 GPC3 HNF1A PPARA SLC37A4
8 reproductive system MP:0005389 9.32 AFP CTNNB1 GPC3 HNF1A IL6ST NR1I2

Drugs & Therapeutics for Liver Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Liver Benign Neoplasm

Genetic Tests for Liver Benign Neoplasm

Anatomical Context for Liver Benign Neoplasm

MalaCards organs/tissues related to Liver Benign Neoplasm:

40
Liver

Publications for Liver Benign Neoplasm

Variations for Liver Benign Neoplasm

Expression for Liver Benign Neoplasm

Search GEO for disease gene expression data for Liver Benign Neoplasm.

Pathways for Liver Benign Neoplasm

Pathways related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1 12.46 TP53 TERT STAT3 IL6ST GSTP1 CTNNB1
2
Show member pathways
12.1 TP53 STAT3 IL6ST CTNNB1
3 12.07 TP53 STAT3 GPC3 CTNNB1
4
Show member pathways
11.67 PPARA NR1I3 NR1I2
5 11.61 TP53 NR1I3 AFP
6
Show member pathways
11.58 GSTP1 CYP2B6 CYP1A1
7 11.51 STAT3 PPARA G6PC1
8 11.47 STAT3 PPARA IL6ST HNF1A CTNNB1
9
Show member pathways
11.42 NR1I3 NR1I2 CYP2B6
10 11.29 TP53 STAT3 HNF1A
11 11.19 HNF1A G6PC1 AFP
12
Show member pathways
11.03 NR1I3 NR1I2 CYP1A1
13 10.73 NR1I3 NR1I2
14 10.72 NR1I2 GSTP1
15 10.47 PPARA NR1I3 NR1I2 CYP2B6
16 10.45 STAT3 PPARA CYP1A1

GO Terms for Liver Benign Neoplasm

Cellular components related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 9.26 TP53 STAT3 HNF1A CTNNB1
2 protein-containing complex GO:0032991 9.1 TP53 HNF1A GOT2 GLUL FABP1 CTNNB1

Biological processes related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 TP53 STAT3 PPARA NR1I3 NR1I2 HNF1A
2 positive regulation of transcription, DNA-templated GO:0045893 9.99 TP53 STAT3 PPARA NR1I2 HNF1A CTNNB1
3 negative regulation of cell proliferation GO:0008285 9.97 TP53 STAT3 GPC3 FRK CTNNB1
4 regulation of cell proliferation GO:0042127 9.86 TP53 STAT3 FRK CTNNB1
5 negative regulation of apoptotic process GO:0043066 9.85 TP53 TERT IL6ST GSTP1 FABP1 CTNNB1
6 xenobiotic metabolic process GO:0006805 9.81 NR1I2 GSTP1 CYP2B6
7 regulation of lipid metabolic process GO:0019216 9.8 PPARA FABP1 CYP1A1
8 cell proliferation GO:0008283 9.78 STAT3 GLUL CYP1A1 CTNNB1
9 response to insulin GO:0032868 9.77 PPARA GOT2 G6PC1
10 negative regulation of transcription by RNA polymerase II GO:0000122 9.76 TP53 STAT3 PPARA NR1I3 NR1I2 HNF1A
11 response to glucose GO:0009749 9.75 SLC37A4 HNF1A GLUL
12 negative regulation of neuron death GO:1901215 9.72 STAT3 PPARA CTNNB1
13 response to organic cyclic compound GO:0014070 9.71 STAT3 SLC37A4 PPARA CYP1A1
14 gluconeogenesis GO:0006094 9.67 SLC37A4 GOT2 G6PC1
15 fatty acid transport GO:0015908 9.65 HNF1A GOT2
16 glutamate metabolic process GO:0006536 9.64 GOT2 GLUL
17 positive regulation of ATP biosynthetic process GO:2001171 9.63 STAT3 PPARA
18 negative regulation of glycolytic process GO:0045820 9.63 STAT3 PPARA
19 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.63 TP53 TERT STAT3
20 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.62 TP53 TERT
21 response to ethanol GO:0045471 9.62 STAT3 PPARA GSTP1 GOT2
22 interleukin-35-mediated signaling pathway GO:0070757 9.61 STAT3 IL6ST
23 interleukin-27-mediated signaling pathway GO:0070106 9.61 STAT3 IL6ST
24 glycogen metabolic process GO:0005977 9.61 SLC37A4 IL6ST G6PC1
25 positive regulation of fatty acid beta-oxidation GO:0032000 9.59 PPARA FABP1
26 sexual reproduction GO:0019953 9.58 STAT3 AFP
27 glucose homeostasis GO:0042593 9.56 STAT3 SLC37A4 HNF1A G6PC1
28 glucose-6-phosphate transport GO:0015760 9.52 SLC37A4 G6PC1
29 steroid metabolic process GO:0008202 9.35 SLC37A4 NR1I2 G6PC1 CYP2B6 CYP1A1
30 intracellular receptor signaling pathway GO:0030522 8.92 STAT3 PPARA NR1I3 NR1I2

Molecular functions related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.88 TP53 STAT3 PPARA NR1I3 NR1I2 HNF1A
2 sequence-specific DNA binding GO:0043565 9.83 STAT3 PPARA NR1I3 NR1I2 HNF1A
3 transcription factor binding GO:0008134 9.72 TP53 STAT3 PPARA HNF1A CTNNB1
4 protein phosphatase binding GO:0019903 9.65 TP53 STAT3 CTNNB1
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.63 TP53 STAT3 PPARA NR1I3 NR1I2 HNF1A
6 MDM2/MDM4 family protein binding GO:0097371 9.46 TP53 PPARA
7 fatty acid binding GO:0005504 9.43 GSTP1 FABP1 AFP
8 estrogen 2-hydroxylase activity GO:0101021 9.37 CYP2B6 CYP1A1
9 nuclear receptor activity GO:0004879 9.26 STAT3 PPARA NR1I3 NR1I2
10 drug binding GO:0008144 8.92 PPARA NR1I2 GSTP1 FABP1

Sources for Liver Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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