MCID: LVR031
MIFTS: 27

Liver Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases
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Aliases & Classifications for Liver Benign Neoplasm

MalaCards integrated aliases for Liver Benign Neoplasm:

Name: Liver Benign Neoplasm 11 14
Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm 11

Classifications:



External Ids:

Disease Ontology 11 DOID:916
NCIt 49 C7103 C7106
ICD10 31 D13.4
UMLS 71 C1333419 C1333976

Summaries for Liver Benign Neoplasm

MalaCards based summary: Liver Benign Neoplasm, also known as epithelial hepatic and intrahepatic bile duct neoplasm, is related to liver sarcoma and hepatocellular adenoma. An important gene associated with Liver Benign Neoplasm is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Liver Benign Neoplasm

Diseases related to Liver Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 liver sarcoma 32.5 CD34 AFP
2 hepatocellular adenoma 31.0 SLC37A4 IL6ST HNF1A GSTP1 GPC3 GOT2
3 extragonadal nonseminomatous germ cell tumor 10.4 G6PC1 AFP
4 sarcomatous intrahepatic cholangiocarcinoma 10.4 GPC3 AFP
5 mixed hepatoblastoma 10.4 GPC3 AFP
6 ovarian embryonal carcinoma 10.4 GPC3 AFP
7 ovarian endodermal sinus tumor 10.4 GPC3 AFP
8 adult teratoma 10.3 TP53 AFP
9 testicular malignant germ cell cancer 10.3 GPC3 AFP
10 intratubular embryonal carcinoma 10.3 TP53 AFP
11 ovarian primitive germ cell tumor 10.3 GPC3 AFP
12 testicular yolk sac tumor 10.3 GPC3 AFP
13 gestational ovarian choriocarcinoma 10.3 TP53 AFP
14 paratesticular lipoma 10.3 TERT AFP
15 ovarian solid teratoma 10.3 CD34 AFP
16 intrahepatic bile duct adenoma 10.3 TP53 HNF1A AFP
17 glycogen storage disease ia 10.3 SLC37A4 HNF1A G6PC1
18 mixed cell type cancer 10.3 TP53 CTNNB1 AFP
19 liver inflammatory pseudotumor 10.3 CD34 AFP
20 malignant teratoma 10.3 TP53 GPC3 AFP
21 mature teratoma 10.3 TP53 GPC3 AFP
22 cystadenofibroma 10.3 TP53 AFP
23 bone squamous cell carcinoma 10.3 TP53 STAT3 CTNNB1
24 colonic lymphangioma 10.3 CD34 AFP
25 skin papilloma 10.3 TP53 STAT3 CTNNB1
26 multifocal osteogenic sarcoma 10.3 TP53 CD34
27 colon adenoma 10.3 TP53 STAT3 CTNNB1
28 hepatic coma 10.3 GLUL AFP
29 pancreatic ductal carcinoma 10.3 TP53 STAT3 CTNNB1
30 breast hemangioma 10.3 TP53 CD34
31 liver leiomyoma 10.3 CD34 AFP
32 hepatic angiomyolipoma 10.3 HNF1A CD34 AFP
33 scrotum neoplasm 10.3 CD34 AFP
34 chorioangioma 10.3 CD34 AFP
35 ureteral obstruction 10.2 TP53 FABP1 CTNNB1
36 childhood medulloblastoma 10.2 TP53 TERT CTNNB1
37 liver lipoma 10.2 CTNNB1 CD34 AFP
38 peliosis hepatis 10.2 GLUL CD34 AFP
39 ovarian large-cell neuroendocrine carcinoma 10.2 TP53 AFP
40 thyroid sarcoma 10.2 TERT CD34
41 testicular fibroma 10.2 CTNNB1 CD34 AFP
42 maturity-onset diabetes of the young, type 3 10.2 IL6ST HNF1A GOT2 FABP1
43 intestinal benign neoplasm 10.2 TP53 STAT3 CTNNB1
44 thyroid gland follicular carcinoma 10.2 TP53 TERT CTNNB1
45 liver leiomyosarcoma 10.2 GPC3 CD34 AFP
46 sclerosing hepatic carcinoma 10.2 GPC3 CD34 AFP
47 ameloblastoma 10.2 TP53 TERT CTNNB1
48 bladder transitional cell papilloma 10.2 TP53 TERT
49 malignant mesenchymoma 10.2 CD34 AFP
50 non-invasive bladder papillary urothelial neoplasm 10.2 TP53 TERT

Graphical network of the top 20 diseases related to Liver Benign Neoplasm:



Diseases related to Liver Benign Neoplasm

Symptoms & Phenotypes for Liver Benign Neoplasm

GenomeRNAi Phenotypes related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.2 AFP CD34 CTNNB1 CYP2E1 FABP1 FRK
2 no effect GR00402-S-2 10.2 CD34 CTNNB1 CYP2E1 FABP1 FRK G6PC1

MGI Mouse Phenotypes related to Liver Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 AFP CD34 CTNNB1 CYP2E1 FABP1 FRK
2 liver/biliary system MP:0005370 10.31 AFP CTNNB1 CYP2E1 FABP1 G6PC1 GLUL
3 growth/size/body region MP:0005378 10.24 CTNNB1 CYP2E1 G6PC1 GLUL GOT2 GPC3
4 neoplasm MP:0002006 10.22 AFP CD34 CTNNB1 CYP2E1 FRK G6PC1
5 cellular MP:0005384 10.17 CD34 CTNNB1 G6PC1 GLUL GPC3 HNF1A
6 renal/urinary system MP:0005367 10.06 CTNNB1 G6PC1 GPC3 HNF1A PPARA SLC37A4
7 reproductive system MP:0005389 9.96 AFP CTNNB1 GPC3 HNF1A IL6ST NR1I2
8 skeleton MP:0005390 9.85 CTNNB1 CYP2E1 G6PC1 GPC3 HNF1A IL6ST
9 mortality/aging MP:0010768 9.83 CTNNB1 CYP2E1 G6PC1 GLUL GOT2 GPC3
10 integument MP:0010771 9.28 CD34 CTNNB1 GPC3 GSTP1 HNF1A IL6ST

Drugs & Therapeutics for Liver Benign Neoplasm

Search Clinical Trials, NIH Clinical Center for Liver Benign Neoplasm

Genetic Tests for Liver Benign Neoplasm

Anatomical Context for Liver Benign Neoplasm

Organs/tissues related to Liver Benign Neoplasm:

MalaCards : Liver

Publications for Liver Benign Neoplasm

Variations for Liver Benign Neoplasm

Expression for Liver Benign Neoplasm

Search GEO for disease gene expression data for Liver Benign Neoplasm.

Pathways for Liver Benign Neoplasm

Pathways related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 SLC37A4 PPARA GSTP1 GPC3 GOT2 GLUL
2
Show member pathways
12.39 STAT3 PPARA NR1I3 NR1I2 GSTP1 FABP1
3
Show member pathways
12.15 TP53 STAT3 IL6ST HNF1A CTNNB1
4 11.72 TP53 G6PC1 CTNNB1
5
Show member pathways
11.6 SLC37A4 GOT2 G6PC1
6 11.56 TP53 NR1I3 AFP
7 11.52 TP53 TERT CTNNB1
8 11.47 STAT3 PPARA IL6ST HNF1A CTNNB1
9 11.35 HNF1A STAT3 TP53
10
Show member pathways
11.21 HNF1A G6PC1 AFP
11 10.74 NR1I3 NR1I2
12 10.73 NR1I2 GSTP1
13 10.64 STAT3 PPARA
14 10.47 PPARA NR1I3 NR1I2 CYP2E1
15 10.36 HNF1A CYP2E1
16 10.33 TP53 STAT3 IL6ST
17 9.97 PPARA NR1I2

GO Terms for Liver Benign Neoplasm

Cellular components related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulator complex GO:0005667 9.28 TP53 STAT3 NR1I2 HNF1A CTNNB1

Biological processes related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.33 CTNNB1 FRK HNF1A NR1I2 NR1I3 PPARA
2 positive regulation of gene expression GO:0010628 10.26 TP53 STAT3 NR1I2 HNF1A CTNNB1 CD34
3 negative regulation of gene expression GO:0010629 10.15 TP53 TERT STAT3 CTNNB1 CD34
4 stem cell proliferation GO:0072089 10.02 TP53 CTNNB1 CD34
5 positive regulation of miRNA transcription GO:1902895 10.01 TP53 TERT STAT3
6 gluconeogenesis GO:0006094 9.95 SLC37A4 PPARA G6PC1
7 glucose homeostasis GO:0042593 9.95 STAT3 SLC37A4 HNF1A G6PC1
8 negative regulation of apoptotic process GO:0043066 9.93 TP53 TERT IL6ST HNF1A GSTP1 FABP1
9 triglyceride metabolic process GO:0006641 9.83 SLC37A4 G6PC1 CYP2E1
10 glucose-6-phosphate transport GO:0015760 9.81 G6PC1 SLC37A4
11 steroid metabolic process GO:0008202 9.8 CYP2E1 G6PC1 NR1I2 SLC37A4
12 glycogen metabolic process GO:0005977 9.77 SLC37A4 IL6ST G6PC1
13 fatty acid transport GO:0015908 9.72 HNF1A GOT2 FABP1
14 intracellular receptor signaling pathway GO:0030522 9.56 STAT3 PPARA NR1I3 NR1I2
15 negative regulation of miRNA maturation GO:1903799 9.02 TP53 TERT HNF1A

Molecular functions related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 10.1 TP53 STAT3 PPARA NR1I3 NR1I2 HNF1A
2 transcription coactivator binding GO:0001223 9.65 TERT PPARA HNF1A
3 RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 9.65 TP53 STAT3 PPARA CTNNB1 CD34
4 fatty acid binding GO:0005504 9.63 AFP FABP1 GSTP1
5 nuclear receptor activity GO:0004879 9.23 STAT3 PPARA NR1I3 NR1I2

Sources for Liver Benign Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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