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MCID: LVR031
MIFTS: 28

Liver Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases
Genes Tissues Related diseases Pathways
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Aliases & Classifications for Liver Benign Neoplasm

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MalaCards integrated aliases for Liver Benign Neoplasm:

Name: Liver Benign Neoplasm 12 15
Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Gastrointestinal diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:916
NCIt 51 C7103 C7106
ICD10 34 D13.4
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Summaries for Liver Benign Neoplasm

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MalaCards based summary : Liver Benign Neoplasm, also known as epithelial hepatic and intrahepatic bile duct neoplasm, is related to hepatocellular adenoma and liver sarcoma. An important gene associated with Liver Benign Neoplasm is GLUL (Glutamate-Ammonia Ligase), and among its related pathways/superpathways are Glucose / Energy Metabolism and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Liver Benign Neoplasm

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Diseases related to Liver Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 hepatocellular adenoma 29.7 CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC GLUL
2 liver sarcoma 11.5
3 simpson-golabi-behmel syndrome 10.2 CTNNB1 GPC3
4 noonan syndrome 10 10.2 G6PC GLUL
5 embryonal sarcoma 10.2 CTNNB1 GPC3
6 testicular malignant germ cell cancer 10.1 AFP GPC3
7 ovarian embryonal carcinoma 10.1 AFP GPC3
8 seminal vesicle tumor 10.0 AFP GPC3
9 embryoma 10.0 AFP GPC3
10 extragonadal nonseminomatous germ cell tumor 10.0 AFP G6PC
11 extragonadal germ cell cancer 10.0 AFP G6PC
12 ovarian endodermal sinus tumor 10.0 AFP GPC3
13 endodermal sinus tumor 10.0 AFP GPC3
14 ovarian primitive germ cell tumor 10.0 AFP GPC3
15 acinar cell carcinoma 9.9 AFP CTNNB1
16 hepatoblastoma 9.9 AFP CTNNB1 GPC3
17 gastrointestinal system cancer 9.9 AFP CTNNB1 GPC3
18 endocrine gland cancer 9.9 AFP CTNNB1 GPC3
19 testicular yolk sac tumor 9.9 AFP GPC3
20 danubian endemic familial nephropathy 9.8 CYP1A1 CYP1A2
21 bile duct adenocarcinoma 9.8 AFP GPC3
22 gastroschisis 9.8 CYP1A1 CYP1A2
23 cholangiocarcinoma 9.8 AFP CTNNB1 GPC3
24 clopidogrel resistance 9.7 CYP1A1 CYP1A2
25 acetaminophen metabolism 9.5 CYP1A1 CYP1A2
26 hepatic adenomas, familial 9.5 AFP CTNNB1 G6PC GPC3 HNF1A
27 hepatocellular carcinoma 8.8 AFP CTNNB1 CYP1A1 G6PC GLUL GPC3

Graphical network of the top 20 diseases related to Liver Benign Neoplasm:



Diseases related to Liver Benign Neoplasm
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Symptoms & Phenotypes for Liver Benign Neoplasm

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GenomeRNAi Phenotypes related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.5 CYP1A2 GLUL HAS1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.5 HAS1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.5 CYP1A2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.5 CYP1A2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.5 HAS1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.5 GLUL
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.5 HAS1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.5 CYP1A2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.5 GLUL
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.5 CYP1A2 GLUL HAS1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.5 GLUL

MGI Mouse Phenotypes related to Liver Benign Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 AFP CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC
2 growth/size/body region MP:0005378 9.97 CTNNB1 CYP1A1 G6PC GLUL GPC3 HNF1A
3 liver/biliary system MP:0005370 9.96 AFP CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC
4 mortality/aging MP:0010768 9.85 AFP CTNNB1 CYP1A1 CYP1A2 G6PC GLUL
5 neoplasm MP:0002006 9.35 AFP CTNNB1 CYP1A2 G6PC IL6ST
6 normal MP:0002873 9.1 CTNNB1 CYP1A1 G6PC GLUL HAS1 IL6ST
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Drugs & Therapeutics for Liver Benign Neoplasm

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Search Clinical Trials , NIH Clinical Center for Liver Benign Neoplasm

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Genetic Tests for Liver Benign Neoplasm

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Anatomical Context for Liver Benign Neoplasm

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MalaCards organs/tissues related to Liver Benign Neoplasm:

42
Liver
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Publications for Liver Benign Neoplasm

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Variations for Liver Benign Neoplasm

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Expression for Liver Benign Neoplasm

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Search GEO for disease gene expression data for Liver Benign Neoplasm.
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Pathways for Liver Benign Neoplasm

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Pathways related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Glucose / Energy Metabolism 4
11.75 CYP1A2 FABP1 GLUL HNF1A
2
Signaling pathways regulating pluripotency of stem cells 38
11.69 CTNNB1 HNF1A IL6ST
3
Adipogenesis 1
11.62 CTNNB1 HNF1A IL6ST
4
Tamoxifen metabolism 1
Show member pathways
 11.1 CYP1A1 CYP1A2
5
Melatonin metabolism and effects 1
11.06 CYP1A1 CYP1A2
6
Nuclear Receptors in Lipid Metabolism and Toxicity 1
11.02 CYP1A2 NR1I3
7
Estrogen metabolism 1
Show member pathways
 10.99 CYP1A1 CYP1A2
8
Erlotinib Pathway, Pharmacokinetics 62
Show member pathways
 10.81 CYP1A1 CYP1A2
9
Naphthalene metabolism 23
10.78 CYP1A1 CYP1A2
10
Ondansetron Pathway, Pharmacokinetics/Pharmacodynamics 62
Show member pathways
 10.46 CYP1A1 CYP1A2
11
FOXA2 and FOXA3 transcription factor networks 1
10.44 AFP G6PC HNF1A
12
Estrogen Receptor Pathway 1
10.27 CYP1A1 CYP1A2
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GO Terms for Liver Benign Neoplasm

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Cellular components related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 8.92 CTNNB1 FABP1 GLUL HNF1A

Biological processes related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.77 CTNNB1 CYP1A2 G6PC
2 branching involved in ureteric bud morphogenesis GO:0001658 9.62 CTNNB1 GPC3
3 glycosaminoglycan biosynthetic process GO:0006024 9.61 GPC3 HAS1
4 glycogen metabolic process GO:0005977 9.61 G6PC IL6ST
5 steroid metabolic process GO:0008202 9.61 CYP1A1 CYP1A2 G6PC
6 regulation of canonical Wnt signaling pathway GO:0060828 9.59 CTNNB1 GPC3
7 osteoclast differentiation GO:0030316 9.58 CTNNB1 GPC3
8 embryonic hindlimb morphogenesis GO:0035116 9.58 CTNNB1 GPC3
9 lung development GO:0030324 9.58 CTNNB1 CYP1A2 GPC3
10 pancreas development GO:0031016 9.57 CTNNB1 HNF1A
11 cellular response to copper ion GO:0071280 9.56 CYP1A1 CYP1A2
12 drug metabolic process GO:0017144 9.55 CYP1A1 CYP1A2
13 response to immobilization stress GO:0035902 9.54 CYP1A1 CYP1A2
14 bone resorption GO:0045453 9.52 CTNNB1 HNF1A
15 long-chain fatty acid biosynthetic process GO:0042759 9.51 CYP1A1 CYP1A2
16 response to food GO:0032094 9.49 CYP1A1 G6PC
17 epoxygenase P450 pathway GO:0019373 9.48 CYP1A1 CYP1A2
18 anterior/posterior axis specification GO:0009948 9.46 CTNNB1 GPC3
19 omega-hydroxylase P450 pathway GO:0097267 9.37 CYP1A1 CYP1A2
20 toxin metabolic process GO:0009404 9.32 CYP1A1 CYP1A2
21 hydrogen peroxide biosynthetic process GO:0050665 9.26 CYP1A1 CYP1A2
22 heterocycle metabolic process GO:0046483 9.16 CYP1A1 CYP1A2
23 porphyrin-containing compound metabolic process GO:0006778 8.96 CYP1A1 CYP1A2
24 dibenzo-p-dioxin metabolic process GO:0018894 8.62 CYP1A1 CYP1A2

Molecular functions related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP1A1 CYP1A2
2 aromatase activity GO:0070330 8.96 CYP1A1 CYP1A2
3 demethylase activity GO:0032451 8.62 CYP1A1 CYP1A2
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Sources for Liver Benign Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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