Liver Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Liver Benign Neoplasm, also known as epithelial hepatic and intrahepatic bile duct neoplasm, is related to liver sarcoma and hepatocellular adenoma. An important gene associated with Liver Benign Neoplasm is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and liver/biliary system

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Related Diseases for Liver Benign Neoplasm

Diseases related to Liver Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)

#	Related Disease	Score	Top Affiliating Genes
1	liver sarcoma	32.5	CD34 AFP
2	hepatocellular adenoma	31.0	SLC37A4 IL6ST HNF1A GSTP1 GPC3 GOT2
3	extragonadal nonseminomatous germ cell tumor	10.4	G6PC1 AFP
4	sarcomatous intrahepatic cholangiocarcinoma	10.4	GPC3 AFP
5	mixed hepatoblastoma	10.4	GPC3 AFP
6	ovarian embryonal carcinoma	10.4	GPC3 AFP
7	ovarian endodermal sinus tumor	10.4	GPC3 AFP
8	adult teratoma	10.3	TP53 AFP
9	testicular malignant germ cell cancer	10.3	GPC3 AFP
10	intratubular embryonal carcinoma	10.3	TP53 AFP
11	ovarian primitive germ cell tumor	10.3	GPC3 AFP
12	testicular yolk sac tumor	10.3	GPC3 AFP
13	gestational ovarian choriocarcinoma	10.3	TP53 AFP
14	paratesticular lipoma	10.3	TERT AFP
15	ovarian solid teratoma	10.3	CD34 AFP
16	intrahepatic bile duct adenoma	10.3	TP53 HNF1A AFP
17	glycogen storage disease ia	10.3	SLC37A4 HNF1A G6PC1
18	mixed cell type cancer	10.3	TP53 CTNNB1 AFP
19	liver inflammatory pseudotumor	10.3	CD34 AFP
20	malignant teratoma	10.3	TP53 GPC3 AFP
21	mature teratoma	10.3	TP53 GPC3 AFP
22	cystadenofibroma	10.3	TP53 AFP
23	bone squamous cell carcinoma	10.3	TP53 STAT3 CTNNB1
24	colonic lymphangioma	10.3	CD34 AFP
25	skin papilloma	10.3	TP53 STAT3 CTNNB1
26	multifocal osteogenic sarcoma	10.3	TP53 CD34
27	colon adenoma	10.3	TP53 STAT3 CTNNB1
28	hepatic coma	10.3	GLUL AFP
29	pancreatic ductal carcinoma	10.3	TP53 STAT3 CTNNB1
30	breast hemangioma	10.3	TP53 CD34
31	liver leiomyoma	10.3	CD34 AFP
32	hepatic angiomyolipoma	10.3	HNF1A CD34 AFP
33	scrotum neoplasm	10.3	CD34 AFP
34	chorioangioma	10.3	CD34 AFP
35	ureteral obstruction	10.2	TP53 FABP1 CTNNB1
36	childhood medulloblastoma	10.2	TP53 TERT CTNNB1
37	liver lipoma	10.2	CTNNB1 CD34 AFP
38	peliosis hepatis	10.2	GLUL CD34 AFP
39	ovarian large-cell neuroendocrine carcinoma	10.2	TP53 AFP
40	thyroid sarcoma	10.2	TERT CD34
41	testicular fibroma	10.2	CTNNB1 CD34 AFP
42	maturity-onset diabetes of the young, type 3	10.2	IL6ST HNF1A GOT2 FABP1
43	intestinal benign neoplasm	10.2	TP53 STAT3 CTNNB1
44	thyroid gland follicular carcinoma	10.2	TP53 TERT CTNNB1
45	liver leiomyosarcoma	10.2	GPC3 CD34 AFP
46	sclerosing hepatic carcinoma	10.2	GPC3 CD34 AFP
47	ameloblastoma	10.2	TP53 TERT CTNNB1
48	bladder transitional cell papilloma	10.2	TP53 TERT
49	malignant mesenchymoma	10.2	CD34 AFP
50	non-invasive bladder papillary urothelial neoplasm	10.2	TP53 TERT

Graphical network of the top 20 diseases related to Liver Benign Neoplasm:

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Symptoms & Phenotypes for Liver Benign Neoplasm

GenomeRNAi Phenotypes related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.2	AFP CD34 CTNNB1 CYP2E1 FABP1 FRK
2	no effect	GR00402-S-2	10.2	CD34 CTNNB1 CYP2E1 FABP1 FRK G6PC1

MGI Mouse Phenotypes related to Liver Benign Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.36	AFP CD34 CTNNB1 CYP2E1 FABP1 FRK
2	liver/biliary system	MP:0005370	10.31	AFP CTNNB1 CYP2E1 FABP1 G6PC1 GLUL
3	growth/size/body region	MP:0005378	10.24	CTNNB1 CYP2E1 G6PC1 GLUL GOT2 GPC3
4	neoplasm	MP:0002006	10.22	AFP CD34 CTNNB1 CYP2E1 FRK G6PC1
5	cellular	MP:0005384	10.17	CD34 CTNNB1 G6PC1 GLUL GPC3 HNF1A
6	renal/urinary system	MP:0005367	10.06	CTNNB1 G6PC1 GPC3 HNF1A PPARA SLC37A4
7	reproductive system	MP:0005389	9.96	AFP CTNNB1 GPC3 HNF1A IL6ST NR1I2
8	skeleton	MP:0005390	9.85	CTNNB1 CYP2E1 G6PC1 GPC3 HNF1A IL6ST
9	mortality/aging	MP:0010768	9.83	CTNNB1 CYP2E1 G6PC1 GLUL GOT2 GPC3
10	integument	MP:0010771	9.28	CD34 CTNNB1 GPC3 GSTP1 HNF1A IL6ST

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Drugs & Therapeutics for Liver Benign Neoplasm

Search Clinical Trials, NIH Clinical Center for Liver Benign Neoplasm

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Genetic Tests for Liver Benign Neoplasm

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Anatomical Context for Liver Benign Neoplasm

Organs/tissues related to Liver Benign Neoplasm:

MalaCards : Liver

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Publications for Liver Benign Neoplasm

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Genes for Liver Benign Neoplasm

Genes related to Liver Benign Neoplasm (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HNF1A	HNF1 Homeobox A	Protein Coding	7.98	DISEASES inferred ¹⁴
2	GLUL	Glutamate-Ammonia Ligase	Protein Coding	7.5	DISEASES inferred ¹⁴
3	CTNNB1	Catenin Beta 1	Protein Coding	7.4	DISEASES inferred ¹⁴
4	FABP1	Fatty Acid Binding Protein 1	Protein Coding	6.99	DISEASES inferred ¹⁴
5	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	6.91	DISEASES inferred ¹⁴
6	AFP	Alpha Fetoprotein	Protein Coding	6.77	DISEASES inferred ¹⁴
7	GPC3	Glypican 3	Protein Coding	6.7	DISEASES inferred ¹⁴
8	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	6.69	DISEASES inferred ¹⁴
9	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	6.65	DISEASES inferred ¹⁴
10	NR1I3	Nuclear Receptor Subfamily 1 Group I Member 3	Protein Coding	6.05	DISEASES inferred ¹⁴
11	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	5.9	DISEASES inferred ¹⁴
12	SLC37A4	Solute Carrier Family 37 Member 4	Protein Coding	5.81	DISEASES inferred ¹⁴
13	TP53	Tumor Protein P53	Protein Coding	5.79	DISEASES inferred ¹⁴
14	FRK	Fyn Related Src Family Tyrosine Kinase	Protein Coding	5.77	DISEASES inferred ¹⁴
15	TERT	Telomerase Reverse Transcriptase	Protein Coding	5.76	DISEASES inferred ¹⁴
16	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	5.73	DISEASES inferred ¹⁴
17	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	5.72	DISEASES inferred ¹⁴
18	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	5.64	DISEASES inferred ¹⁴
19	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	5.55	DISEASES inferred ¹⁴
20	CD34	CD34 Molecule	Protein Coding	5.54	DISEASES inferred ¹⁴
21	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	5.52	DISEASES inferred ¹⁴
22	KRT19	Keratin 19	Protein Coding	5.5	DISEASES inferred ¹⁴
23	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	5.48	DISEASES inferred ¹⁴
24	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	5.42	DISEASES inferred ¹⁴
25	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	5.42	DISEASES inferred ¹⁴
26	INHBE	Inhibin Subunit Beta E	Protein Coding	5.4	DISEASES inferred ¹⁴
27	AXIN1	Axin 1	Protein Coding	5.35	DISEASES inferred ¹⁴

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Variations for Liver Benign Neoplasm

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Expression for Liver Benign Neoplasm

Search GEO for disease gene expression data for Liver Benign Neoplasm.

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Pathways for Liver Benign Neoplasm

Pathways related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolism of lipids ⁶⁶	13.66	SLC37A4 PPARA GSTP1 GPC3 GOT2 GLUL
2	Nuclear receptors meta-pathway ⁷⁴ Show member pathways NRF2 pathway ⁷⁴	12.39	STAT3 PPARA NR1I3 NR1I2 GSTP1 FABP1
3	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.15	TP53 STAT3 IL6ST HNF1A CTNNB1
4	DNA damage response (only ATM dependent) ⁷⁴	11.72	TP53 G6PC1 CTNNB1
5	gluconeogenesis III ⁶¹ Show member pathways gluconeogenesis ⁶¹ Gluconeogenesis ⁶⁶	11.6	SLC37A4 GOT2 G6PC1
6	Glucocorticoid receptor regulatory network ⁶¹	11.56	TP53 NR1I3 AFP
7	Head and neck squamous cell carcinoma ⁷⁴	11.52	TP53 TERT CTNNB1
8	Adipogenesis ⁷⁴	11.47	STAT3 PPARA IL6ST HNF1A CTNNB1
9	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.35	HNF1A STAT3 TP53
10	FOXA2 and FOXA3 transcription factor networks ⁶¹ Show member pathways FOXA transcription factor networks ⁶¹	11.21	HNF1A G6PC1 AFP
11	Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics ⁶⁰	10.74	NR1I3 NR1I2
12	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.73	NR1I2 GSTP1
13	Estrogen receptor pathway ⁷⁴	10.64	STAT3 PPARA
14	Nuclear receptors in lipid metabolism and toxicity ⁷⁴	10.47	PPARA NR1I3 NR1I2 CYP2E1
15	Dichloroethylene metabolism ²²	10.36	HNF1A CYP2E1
16	Mammary gland development pathway - Involution (Stage 4 of 4) ⁷⁴	10.33	TP53 STAT3 IL6ST
17	Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists ⁷⁴	9.97	PPARA NR1I2

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GO Terms for Liver Benign Neoplasm

Cellular components related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription regulator complex	GO:0005667	9.28	TP53 STAT3 NR1I2 HNF1A CTNNB1

Biological processes related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription by RNA polymerase II	GO:0000122	10.33	CTNNB1 FRK HNF1A NR1I2 NR1I3 PPARA
2	positive regulation of gene expression	GO:0010628	10.26	TP53 STAT3 NR1I2 HNF1A CTNNB1 CD34
3	negative regulation of gene expression	GO:0010629	10.15	TP53 TERT STAT3 CTNNB1 CD34
4	stem cell proliferation	GO:0072089	10.02	TP53 CTNNB1 CD34
5	positive regulation of miRNA transcription	GO:1902895	10.01	TP53 TERT STAT3
6	gluconeogenesis	GO:0006094	9.95	SLC37A4 PPARA G6PC1
7	glucose homeostasis	GO:0042593	9.95	STAT3 SLC37A4 HNF1A G6PC1
8	negative regulation of apoptotic process	GO:0043066	9.93	TP53 TERT IL6ST HNF1A GSTP1 FABP1
9	triglyceride metabolic process	GO:0006641	9.83	SLC37A4 G6PC1 CYP2E1
10	glucose-6-phosphate transport	GO:0015760	9.81	G6PC1 SLC37A4
11	steroid metabolic process	GO:0008202	9.8	CYP2E1 G6PC1 NR1I2 SLC37A4
12	glycogen metabolic process	GO:0005977	9.77	SLC37A4 IL6ST G6PC1
13	fatty acid transport	GO:0015908	9.72	HNF1A GOT2 FABP1
14	intracellular receptor signaling pathway	GO:0030522	9.56	STAT3 PPARA NR1I3 NR1I2
15	negative regulation of miRNA maturation	GO:1903799	9.02	TP53 TERT HNF1A

Molecular functions related to Liver Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001228	10.1	TP53 STAT3 PPARA NR1I3 NR1I2 HNF1A
2	transcription coactivator binding	GO:0001223	9.65	TERT PPARA HNF1A
3	RNA polymerase II-specific DNA-binding transcription factor binding	GO:0061629	9.65	TP53 STAT3 PPARA CTNNB1 CD34
4	fatty acid binding	GO:0005504	9.63	AFP FABP1 GSTP1
5	nuclear receptor activity	GO:0004879	9.23	STAT3 PPARA NR1I3 NR1I2

Sources

Sources for Liver Benign Neoplasm

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LVR031 MIFTS: 27	Liver Benign Neoplasm Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases	Data Licensing For inquiries, contact: [email protected]
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