MCID: LVR003
MIFTS: 24

Liver Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases
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Aliases & Classifications for Liver Carcinoma in Situ

MalaCards integrated aliases for Liver Carcinoma in Situ:

Name: Liver Carcinoma in Situ 11 14
Carcinoma in Situ of Liver, Gallbladder and Bile Ducts 11
Carcinoma in Situ of Liver and Biliary System 11

Classifications:



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Disease Ontology 11 DOID:9132
ICD9CM 34 230.8
SNOMED-CT 68 271525004
ICD10 31 D01.5
UMLS 71 C0496854

Summaries for Liver Carcinoma in Situ

Disease Ontology: 11 An in situ carcinoma that is located in the liver.

MalaCards based summary: Liver Carcinoma in Situ, also known as carcinoma in situ of liver, gallbladder and bile ducts, is related to prolapse of urethra and amyotrophic lateral sclerosis 3. An important gene associated with Liver Carcinoma in Situ is ATF7IP (Activating Transcription Factor 7 Interacting Protein), and among its related pathways/superpathways are Alzheimer's disease and miRNA effects and Selective autophagy. Affiliated tissues include liver, and related phenotype is mortality/aging.

Related Diseases for Liver Carcinoma in Situ

Graphical network of the top 20 diseases related to Liver Carcinoma in Situ:



Diseases related to Liver Carcinoma in Situ

Symptoms & Phenotypes for Liver Carcinoma in Situ

MGI Mouse Phenotypes related to Liver Carcinoma in Situ:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.4 AMBRA1 ATG13 ATG5 BECN1 EIF4EBP1 EPHB4

Drugs & Therapeutics for Liver Carcinoma in Situ

Search Clinical Trials, NIH Clinical Center for Liver Carcinoma in Situ

Genetic Tests for Liver Carcinoma in Situ

Anatomical Context for Liver Carcinoma in Situ

Organs/tissues related to Liver Carcinoma in Situ:

FMA: Liver
MalaCards : Liver

Publications for Liver Carcinoma in Situ

Variations for Liver Carcinoma in Situ

Expression for Liver Carcinoma in Situ

Search GEO for disease gene expression data for Liver Carcinoma in Situ.

Pathways for Liver Carcinoma in Situ

Pathways related to Liver Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 BECN1 ATG14 ATG13 AMBRA1
2
Show member pathways
12.29 SQSTM1 MAP1LC3B HSP90AA1 HDAC6 GABARAP BECN1
3
Show member pathways
12.18 MAP1LC3B EPHB4 EPHA1 BECN1 ATG5 ATG14
4
Show member pathways
11.91 MAP1LC3B BECN1 ATG5 ATG14 ATG13 AMBRA1
5 11.64 AMBRA1 ATG13 ATG5 BECN1 MAP1LC3B SQSTM1
6 11.6 SQSTM1 PKM LDHA
7 11.58 SQSTM1 HDAC6 BECN1
8
Show member pathways
11.37 SQSTM1 MAP1LC3B ATG5
9 11.25 SQSTM1 MAP1LC3B GABARAP BECN1 ATG5 ATG14
10 11 EIF4EBP1 ATG13
11 10.97 BECN1 ATG14
12 10.36 PKM LDHA
13 10.34 PKM LDHA
14 10.32 BECN1 ATG14 AMBRA1

GO Terms for Liver Carcinoma in Situ

Cellular components related to Liver Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.33 AMBRA1 ATF7IP ATG13 ATG14 ATG5 BECN1
2 cytoplasmic vesicle GO:0031410 10.01 SQSTM1 MAP1LC3B GABARAP BECN1 ATG14 AMBRA1
3 phagocytic vesicle GO:0045335 9.91 BECN1 ATG14 AMBRA1
4 autophagosome membrane GO:0000421 9.85 MAP1LC3B GABARAP ATG14
5 phagophore assembly site GO:0000407 9.73 SQSTM1 BECN1 ATG13
6 axoneme GO:0005930 9.65 MAP1LC3B GABARAP ATG5 ATG14 AMBRA1
7 phosphatidylinositol 3-kinase complex, class III GO:0035032 9.62 ATG14 BECN1
8 autophagosome GO:0005776 9.47 SQSTM1 MAP1LC3B GABARAP BECN1 ATG5 ATG14

Biological processes related to Liver Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 10.18 ATG13 ATG14 BECN1 EPHA1 EPHB4 SQSTM1
2 macroautophagy GO:0016236 10.15 ATG14 ATG5 BECN1 GABARAP MAP1LC3B SQSTM1
3 autophagy of mitochondrion GO:0000422 10.1 SQSTM1 MAP1LC3B GABARAP BECN1 ATG5 AMBRA1
4 autophagosome assembly GO:0000045 10.1 MAP1LC3B GABARAP BECN1 ATG5 ATG14 ATG13
5 positive regulation of autophagy GO:0010508 10.03 BECN1 ATG13 AMBRA1
6 regulation of macroautophagy GO:0016241 10.01 HDAC6 BECN1 ATG14
7 cellular response to nitrogen starvation GO:0006995 10.01 MAP1LC3B GABARAP BECN1 ATG5
8 cellular response to starvation GO:0009267 9.98 MAP1LC3B ATG5 ATG14 AMBRA1
9 autophagosome maturation GO:0097352 9.93 MAP1LC3B BECN1 ATG14
10 mitophagy GO:0000423 9.93 AMBRA1 ATG13 ATG14 BECN1 MAP1LC3B SQSTM1
11 regulation of protein complex stability GO:0061635 9.87 SQSTM1 ATG14
12 selective autophagy GO:0061912 9.85 SQSTM1 BECN1
13 chaperone-mediated autophagy GO:0061684 9.83 HSP90AA1 ATG5
14 aggrephagy GO:0035973 9.81 SQSTM1 ATG5
15 response to iron(II) ion GO:0010040 9.8 BECN1 ATG5
16 response to mitochondrial depolarisation GO:0098780 9.65 SQSTM1 BECN1 ATG14 ATG13 AMBRA1
17 autophagy GO:0006914 9.5 SQSTM1 MAP1LC3B HDAC6 GABARAP BECN1 ATG5

Molecular functions related to Liver Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane-ephrin receptor activity GO:0005005 9.56 EPHB4 EPHA1
2 GTPase binding GO:0051020 9.56 HSP90AA1 BECN1 ATG14 AMBRA1
3 ubiquitin protein ligase binding GO:0031625 9.47 SQSTM1 MAP1LC3B HSP90AA1 HDAC6 GABARAP BECN1
4 ephrin receptor activity GO:0005003 9.33 EPHB4 EPHA1

Sources for Liver Carcinoma in Situ

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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