Liver Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LVR013 MIFTS: 68	Liver Disease Categories: Blood diseases, Bone diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Metabolic diseases, Nephrological diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Liver Disease

MalaCards integrated aliases for Liver Disease:

Name: Liver Disease ¹² ¹⁵ ³⁷ ¹⁷

Liver Diseases ⁵⁴ ⁴² ⁴³ ⁷¹

Abnormality of the Liver ²⁹ ⁶

Liver Dysfunction ⁵⁴ ⁷¹

Liver Failure ⁵⁴ ⁷¹

Disorder of Liver ¹²

Hepatic Disorder ¹²

Hepatic Failure ²⁹

Hepatic Disease ¹⁵

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Metabolic diseases
Anatomical: Gastrointestinal diseases Liver diseases Bone diseases Nephrological diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the digestive system

Diseases of liver

Hepatic failure, not elsewhere classified

Hepatic failure, unspecified

Liver disorders in diseases classified elsewhere

Liver disorders in other diseases classified elsewhere

Other diseases of liver

Liver disease, unspecified

Other specified diseases of liver

External Ids:

Disease Ontology ¹² DOID:409

ICD9CM ³⁴ 573.9

MeSH ⁴³ D008107

NCIt ⁴⁹ C3196

SNOMED-CT ⁶⁷ 235856003

ICD10 ³² K70-K77 K72 K72.9 more

EFO ¹⁷ EFO_0001421

UMLS ⁷¹ C0023895 C0085605 C0086565

Sources

Summaries for Liver Disease

MedlinePlus : ⁴² Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. There are many kinds of liver diseases: Diseases caused by viruses, such as hepatitis A, hepatitis B, and hepatitis C Diseases caused by drugs, poisons, or too much alcohol. Examples include fatty liver disease and cirrhosis. Liver cancer Inherited diseases, such as hemochromatosis and Wilson disease Symptoms of liver disease can vary, but they often include swelling of the abdomen and legs, bruising easily, changes in the color of your stool and urine, and jaundice, or yellowing of the skin and eyes. Sometimes there are no symptoms. Tests such as imaging tests and liver function tests can check for liver damage and help to diagnose liver diseases.

MalaCards based summary : Liver Disease, also known as liver diseases, is related to fatty liver disease and polycystic liver disease, and has symptoms including nausea and vomiting, abdominal pain and constipation. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Folate Metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and kidney, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : ⁷⁴ Liver disease (also called hepatic disease) is a type of damage to or disease of the liver. Whenever the... more...

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Related Diseases for Liver Disease

Diseases in the Liver Disease family:

Liver Failure, Infantile, Transient	Infantile Liver Failure Syndrome 1
Infantile Liver Failure Syndrome 2	Infantile Liver Failure Syndrome 3
Acute Liver Failure

Diseases related to Liver Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1928)

#	Related Disease	Score	Top Affiliating Genes
1	fatty liver disease	35.4	SLC17A5 PNPLA3 INS GPT GGT1 ALB
2	polycystic liver disease	35.3	SERPINA1 SEC63 PRKCSH PKHD1 PKD1 LRP5
3	non-alcoholic fatty liver disease	35.3	PNPLA3 INS GPT GGT1 ALB ADIPOQ
4	polycystic liver disease 1 with or without kidney cysts	35.2	SEC63 PRKCSH PKHD1 PKD1 LRP5
5	fatty liver disease, nonalcoholic 1	35.2	SLC17A5 PNPLA3 INS GPT GGT1 ADIPOQ
6	polycystic kidney disease 4 with or without polycystic liver disease	35.1	SEC63 PRKCSH PKHD1 PKD1 GANAB
7	polycystic kidney disease 2 with or without polycystic liver disease	35.0	SEC63 PRKCSH PKHD1 PKD1
8	polycystic kidney disease 1 with or without polycystic liver disease	35.0	SEC63 PRKCSH PKHD1 PKD1
9	alcoholic hepatitis	34.3	SLC17A5 PNPLA3 GPT GGT1 F2 ALB
10	non-alcoholic steatohepatitis	34.3	PNPLA3 INS GPT GGT1 ALB ADIPOQ
11	primary biliary cirrhosis	33.7	SLC17A5 GPT GGT1 F2 DLAT ALB
12	alpha-1-antitrypsin deficiency	33.7	SERPINA1 GPT F2 ALB
13	hepatic vascular disease	33.6	SERPINA1 PKHD1 GPT GGT1 F2 ALB
14	wilson disease	33.5	PNPLA3 GPT F2 ALB
15	bile acid synthesis defect, congenital, 1	33.5	HSD3B7 GGT1 ALB
16	cholangitis, primary sclerosing	33.4	SERPINA1 GPT GGT1 F2 DLAT ALB
17	alcohol use disorder	33.4	SLC17A5 GPT GGT1 ALB
18	sclerosing cholangitis	33.2	GPT GGT1 F2 ALB ABCB11
19	hepatic encephalopathy	33.2	SLC17A5 GPT F2 ALB
20	acute liver failure	33.2	SLC17A5 GPT F2 ALB
21	hepatorenal syndrome	33.0	GPT F2 ALB
22	congenital hepatic fibrosis	33.0	PKHD1 PKD1
23	autoimmune hepatitis	33.0	SLC17A5 GPT GGT1 F2 DLAT ALB
24	drug-induced hepatitis	32.9	GPT F2 ALB
25	liver cirrhosis	32.9	SLC17A5 SERPINA1 MEG3 GPT GGT1 FAH
26	idiopathic edema	32.7	INS ADIPOQ
27	alcoholic liver cirrhosis	32.6	SLC17A5 PNPLA3 INS GPT F2 ALB
28	viral hepatitis	32.5	SLC17A5 SERPINA1 PNPLA3 INS GPT GGT1
29	portal hypertension	32.5	PNPLA3 PKHD1 INS GPT F2 ALB
30	cholestasis	32.5	SLC17A5 SERPINA1 HSD3B7 GPT GGT1 F2
31	cholangitis	32.4	SLC17A5 GPT GGT1 F2 DLAT ALB
32	hepatic coma	32.3	GPT F2 ALB
33	hepatitis b	32.2	SLC17A5 GPT GGT1 F2 ALB
34	hepatitis a	32.1	INS GPT GGT1 F2 ALB
35	polycystic kidney disease	32.1	PRKCSH PKHD1 PKD1 LRP5 GANAB ALB
36	kidney disease	32.1	PKHD1 PKD1 LRP5 INS GANAB ALB
37	granulomatous hepatitis	32.0	GPT ALB
38	esophageal varix	32.0	SERPINA1 PKHD1 GPT GGT1 F2 ALB
39	biliary atresia	31.9	GPT GGT1 F2 ALB ABCB11
40	autosomal dominant polycystic kidney disease	31.9	PKHD1 PKD1 LRP5 INS GANAB ALB
41	glucose intolerance	31.8	INS GPT ALB ADIPOQ
42	sleep apnea	31.8	INS GPT ALB ADIPOQ
43	body mass index quantitative trait locus 11	31.8	SLC17A5 PNPLA3 INS GPT GGT1 ALB
44	hyperuricemia	31.7	INS GPT GGT1 ALB
45	obstructive jaundice	31.7	SLC17A5 GPT GGT1 F2 ALB
46	hypothyroidism	31.7	INS GPT F2 ALB ADIPOQ
47	bilirubin metabolic disorder	31.7	SLC17A5 GPT GGT1 F2 ALB ABCB11
48	hepatitis e	31.7	GPT GGT1 F2 ALB
49	cholelithiasis	31.7	SERPINA1 INS GPT GGT1 ALB
50	schistosomiasis	31.6	GPT GGT1 F2 ALB

Comorbidity relations with Liver Disease via Phenotypic Disease Network (PDN):

Active Peptic Ulcer Disease	Acute Cystitis
Acute Pancreatitis	Deficiency Anemia
Familial Atrial Fibrillation	Heart Disease
Hepatic Encephalopathy	Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Liver Disease:

Sources

Symptoms & Phenotypes for Liver Disease

UMLS symptoms related to Liver Disease:

nausea and vomiting, abdominal pain, constipation, diarrhea, hepatosplenomegaly, icterus, dyspepsia, heartburn, gastrointestinal gas, digestive system symptom, liver tender, abnormal bruising

MGI Mouse Phenotypes related to Liver Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.1	ADIPOQ ALB F2 FAH GGT1 INS
2	homeostasis/metabolism	MP:0005376	10.1	ABCB11 ADIPOQ ALB F2 FAH GGT1
3	liver/biliary system	MP:0005370	9.93	ABCB11 ADIPOQ ALB FAH HSD3B7 INS
4	mortality/aging	MP:0010768	9.86	ABCB11 ADIPOQ ALB DLAT F2 FAH
5	renal/urinary system	MP:0005367	9.28	ADIPOQ ALB FAH GGT1 INS PKD1

Sources

Drugs & Therapeutics for Liver Disease

Drugs for Liver Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1032)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Dalteparin

Approved

Phase 4

9005-49-6

Tinzaparin

Approved

Phase 4

9041-08-1, 9005-49-6

25244225

Acamprosate

Approved, Investigational

Phase 4

77337-76-9

71158

Telmisartan

Approved, Investigational

Phase 4

144701-48-4

65999

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Azithromycin

Approved

Phase 4

83905-01-5

447043 55185

Nitazoxanide

Approved, Investigational, Vet_approved

Phase 4

55981-09-4

41684

Pentoxifylline

Approved, Investigational

Phase 4

6493-05-6

4740

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Emtricitabine

Approved, Investigational

Phase 4

143491-57-0

60877

Vancomycin

Approved

Phase 4

1404-90-6

14969 441141

Imipenem

Approved

Phase 4

74431-23-5, 64221-86-9

104838

Insulin glulisine

Approved

Phase 4

207748-29-6

Lixisenatide

Approved

Phase 4

320367-13-3

Arsenic trioxide

Approved, Investigational

Phase 4

1327-53-3

518740

Insulin lispro

Approved

Phase 4

133107-64-9

Atenolol

Approved

Phase 4

29122-68-7

2249

Nebivolol

Approved, Investigational

Phase 4

99200-09-6, 118457-14-0, 152520-56-4

71301

Cefotaxime

Approved

Phase 4

63527-52-6

5742673 456256

Cefoxitin

Approved

Phase 4

35607-66-0

441199

Temocillin

Approved, Investigational

Phase 4

66148-78-5

Caspofungin

Approved

Phase 4

162808-62-0, 179463-17-3

2826718 468682

Clotrimazole

Approved, Vet_approved

Phase 4

23593-75-1

2812

Miconazole

Approved, Investigational, Vet_approved

Phase 4

22916-47-8

4189

Aspirin

Approved, Vet_approved

Phase 4

50-78-2

2244

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

Naloxone

Approved, Vet_approved

Phase 4

465-65-6

5284596

Buprenorphine

Approved, Illicit, Investigational, Vet_approved

Phase 4

52485-79-7

40400 644073

Ethanolamine oleate

Approved

Phase 4

2272-11-9

Tocopherol

Approved, Investigational

Phase 4

1406-66-2, 54-28-4

14986

Pravastatin

Approved

Phase 4

81093-37-0

54687

Iron

Approved, Experimental

Phase 4

15438-31-0, 7439-89-6

27284 23925

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Nicotinamide

Approved, Investigational

Phase 4

98-92-0

936

Rifampicin

Approved

Phase 4

13292-46-1

5381226 5458213

Baclofen

Approved

Phase 4

1134-47-0

2284

Anidulafungin

Approved, Investigational

Phase 4

166663-25-8

166548

Perindopril

Approved

Phase 4

107133-36-8, 82834-16-0

107807

Liraglutide

Approved

Phase 4

204656-20-2

44147092

Dobutamine

Approved

Phase 4

34368-04-2

36811

Hyaluronic acid

Approved, Vet_approved

Phase 4

9004-61-9

53477741

Adefovir dipivoxil

Approved, Investigational

Phase 4

142340-99-6

60871

Neostigmine

Approved, Vet_approved

Phase 4

59-99-4

4456

Atropine

Approved, Vet_approved

Phase 4

51-55-8, 5908-99-6

174174

Deferiprone

Approved

Phase 4

30652-11-0

2972

Interventional clinical trials:

(show top 50) (show all 4111)

#	Name	Status	NCT ID	Phase	Drugs
1	Granulocyte Colony-stimulating Factor(G-CSF) in the Treatment of Hepatic Failure: a Prospective Randomized Controlled Clinical Study	Unknown status	NCT02331745	Phase 4	Granulocyte colony-stimulating factor;standard treatment
2	THE EFFECT OF DUAL TREATMENT WITH L-CARNITINE AND MAGNESIUM ON Patients With Non Alcoholic Fatty Liver Disease	Unknown status	NCT01956825	Phase 4
3	Randomised Controlled Study Comparing Use of Popofol Plus Fentanyl Versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients With Advanced Liver Disease.	Unknown status	NCT03063866	Phase 4	Propofol;Midazolam;Fentanyl
4	Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease	Unknown status	NCT00941642	Phase 4	Lovaza;placebo control
5	Intravenous-Morphine and Glucagon-Usage Enhanced MR Cholangiography	Unknown status	NCT00155376	Phase 4	morphine and glucagon
6	Evaluation of Perindopril and Telmisartan for the Treatment of Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial	Unknown status	NCT02213224	Phase 4	Perindopril;Telmisartan;Amlodipine
7	Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography	Unknown status	NCT02757170	Phase 4
8	Branched-chain Amino Acid (BCAA) on Progression of Advanced Liver Disease (BRAVE): Korean Nation-wide Multicenter Retrospective and Prospective Observational Cohort Study	Unknown status	NCT02837302	Phase 4	Livact
9	An Randomized Open Label Trial on the Impact of 24 Weeks of Atorvastatin Therapy on Liver Fat Content and Abdominal Fat Content in Patients With Type 2 Diabetes Combined With High LDL-C and Non-alcoholic Fatty Liver Disease	Unknown status	NCT01720719	Phase 4	atorvastatin;Vitamin E
10	Influence of CYP3A5 Polymorphism on Liver Function Abnormality and the Trough Level Change After Conversion From Tacrolimus (Bid) to Advagraf® (qd) in Stable Liver Transplant Recipients	Unknown status	NCT02882113	Phase 4	Advagraf
11	A Randomized, Open Label, Phase IV, Multicenter Study for Efficacy and Safety of Lamivudine Versus Entecarvir Therapy in HBV-related Advanced Liver Disease Patients With High Viral Load and Normal or Slightly Elevated Transaminase	Unknown status	NCT00823550	Phase 4	Entecavir;Lamivudine
12	Effect of Probiotics on Gut-Liver Axis of Alcoholic Hepatitis	Unknown status	NCT02335632	Phase 4	Probiotics (Lacidofil®);Placebo
13	Entecavir for Patients With Decompensated HBV-Related Cirrhosis:a Prospective Randomized Controlled Trial	Unknown status	NCT00663182	Phase 4	Entecavir
14	Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion	Unknown status	NCT01786759	Phase 4	ClinOleic;Intralipid
15	Development of an Imaging Biomarker for Hepatic Fibrosis Using Gadoxetate Disodium	Unknown status	NCT01783314	Phase 4
16	Safety of Acamprosate for Alcohol Dependence in the Elderly: An Open-Label Study	Unknown status	NCT00655967	Phase 4	Acamprosate (Campral);Acamprosate
17	Intravenous Paracetamol Versus Intravenous Dexketoprofen in Patients Presented With Dysmenorrhea in Emergency Department	Unknown status	NCT02373514	Phase 4	Paracetamol;Dexketoprofen
18	A Randomised Controlled Trial of Lifestyle Versus Ezetimibe Plus Lifestyle in Patients With Non-alcoholic Steatohepatitis	Unknown status	NCT01950884	Phase 4	Ezetimibe
19	A Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Intra-articular Catheter (IAC) Following Primary Total Knee Arthroplasty	Unknown status	NCT02497911	Phase 4	Ropivicaine;Bupivicaine
20	Magnesium Deficiency in Cirrhotic Patients	Unknown status	NCT01894867	Phase 4
21	The Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin in People With Type 2 Diabetes and Chronic Liver Diseases	Unknown status	NCT01337440	Phase 4	UDCA;Sitagliptin
22	The Orange-III Trial: Optimised Recovery With Movicol® Preoperatively Within an Enhanced Recovery Programme, a Randomised Controlled Trial	Unknown status	NCT01429779	Phase 4	Movicol
23	A Study Comparing Thymoglobulin to Tacrolimus in Liver Transplant and Impact on Renal Function	Unknown status	NCT00564538	Phase 4	anti-thymocyte globulin (rabbit);tacrolimus
24	Sustained Off-treatment Response After HBeAg Loss in HBeAg-Pos Chronic Hepatitis B Patients Treated With Nucleos(t)Ide Analogues	Unknown status	NCT01911156	Phase 4	Continue NA treatment;Discontinue NA Treatment
25	Influence of Hepatic Steatosis on the Therapeutic Effect of Entecavir in Chronic Hepatitis B Patients-A Randomized, Double-Blinded, Controlled Trial	Unknown status	NCT01148576	Phase 4	entecavir;entecavir;essentiale + entecavir;Vitamin E + entecavir
26	Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhosis: An Open Label, Randomized Controlled Trial of Lactulose, Probiotics and No-therapy	Unknown status	NCT01178372	Phase 4	Lactulose;Probiotics(VSL#3)
27	A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty	Unknown status	NCT02603900	Phase 4	ropivacaine;bupivacaine
28	Phase IV Study of Effectiveness of Interferon and Ribavirin Treatment in Thalassemia Major Patients With Chronic Viral Hepatitis C	Unknown status	NCT00887081	Phase 4	PEG-IFN alpha2a or PEG-IFN alpha2b and Ribavirin
29	HBsAg Loss/Seroconversion in Low Replicative Chronic HBV Infection Patients With Low Level HBsAg Treated With Peginterferon Alpha	Unknown status	NCT02908763	Phase 4	peginterferon alfa
30	The Efficacy and Safety Study of Magnesium Isoglycyrrhizinate Injection Followed by Diammonium Glycyrrhizinate Enteric-coated Capsules and Combined With Entecavir on the Treatment of Chronic Hepatitis B	Unknown status	NCT03349008	Phase 4	Entecavir;Magnesium Isoglycyrrhizinate;Diammonium Glycyrrhizinate;Magnesium Isoglycyrrhizinate Placebo;Diammonium Glycyrrhizinate Placebo
31	Insulin Therapy in the Inpatient Management of Cirrhotic Patients With Type 2 Diabetes	Unknown status	NCT01143948	Phase 4	Glargine & Glulisine;Regular insulin;NPH & regular insulin
32	The Optimizing Treatment of Peginterferon Alpha in HBeAg-negative Chronic Hepatitis B Virus Patients With Low Level HBsAg	Unknown status	NCT02893124	Phase 4	peginterferon alfa
33	Efficacy and Safety of Certican® in Combination With Myfortic® in Adult Renal Allograft Recipients Following Calcineurin Inhibitor Withdrawal at Week 16 Compared to Patients Who Are Maintained on Tacrolimus and Myfortic®	Unknown status	NCT01399242	Phase 4	Certican
34	The Effect of the GLP-1 Receptor Agonists on Blood Levels of Lipoprotein (a)	Unknown status	NCT02501850	Phase 4	Liraglutide;metformin
35	Randomized, Multicenter, Open -Label Clinical Trial to Study the Effect of Adding on Pegylated Interferon Therapy for Patients Diagnosed With Chronic Hepatitis B Showing Maintained Response While Receiving Ongoing Nucleotide Analogues	Unknown status	NCT02982837	Phase 4	PEG-IFN & Nucleos(t)tide analogues;Nucleos(t)tide analogues
36	Phase IV Study of the Efficacy of Entecavir in Patients With Chronic Hepatitis B Virus Infection and Persistently Normal Alanine Aminotransferase	Unknown status	NCT01833611	Phase 4	Entecavir;placebo
37	A Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis	Unknown status	NCT00761098	Phase 4	Standard Care;Experimental
38	An Efficacy and Safety Study Comparing Pegylated-Interferon and Ribavirin Plus Metformin to Pegylated-Interferon and Ribavirin in the Treatment of naïve Patients With Genotype 1 Chronic HCV Infection and Insulin Resistance	Unknown status	NCT00370617	Phase 4	metformin
39	A Phase 4, Open-Label Study to Investigate the Efficacy and Safety of Tenofovir Disoproxil Fumarate (Viread(R)) in Preventing Hepatocellular Carcinoma Recurrence in Chronic Hepatitis B Virus Infected Patients With Low Viral Load at Baseline Treated With Radiofrequency Ablation or Resection	Unknown status	NCT02308319	Phase 4	Tenofovir disoproxil fumarate
40	The Effect of Empagliflozin on NAFLD in Asian Patients With Type 2 Diabetes	Unknown status	NCT02964715	Phase 4	Empagliflozin
41	Randomized Controlled Trial Comparing Effects of Sedation for Upper Gastrointestinal Endoscopy With Propofol Versus Midazolam on Psychometric Tests and Critical Flicker Frequency in Cirrhotics	Unknown status	NCT01356121	Phase 4	Propofol;Midazolam
42	RCT of Carvedilol vs Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage	Unknown status	NCT01070641	Phase 4	Carvedilol
43	Treating HIV-infected Elite Controllers as a Model of HIV Remission	Unknown status	NCT01025427	Phase 4	Raltegravir, tenofovir/emtricitabine
44	A Randomised, Open-label Clinical Trial Assessing the Efficacy and Safety of Mycophenolate Mofetil Versus Azathioprine for Induction of Remission in Treatment Naive Autoimmune Hepatitis	Unknown status	NCT02900443	Phase 4	Mycophenolate mofetil;Azathioprine
45	the Safety and Effect in TB Patients With NAC	Unknown status	NCT02889757	Phase 4	Acteylcysteine
46	Treatment of Relapsed Acute Promyelocytic Leukemia With Arsenic Trioxide (Phase IV Study)	Unknown status	NCT00196768	Phase 4	Arsenic trioxide;Trisenox
47	Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled，Clinical Study.	Unknown status	NCT02232945	Phase 4	placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
48	Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics- Double Blind Placebo Controlled Study	Unknown status	NCT00845936	Phase 4	Metformin
49	Randomized Trial of Switch to Tenofovir Versus Continue Lamivudine/Adefovir Treatment in Lamivudine-resistance Chronic Hepatitis B Patients Who Have Undergone Lamivudine/Adefovir Add-on Treatment	Unknown status	NCT01491295	Phase 4	Tenofovir disoproxil fumarate;Lamivudine plus adefovir
50	Effect of Liraglutide on Fatty Liver Content Evaluated by Proton-spectroscopy (1H-spectroscopy) and Lipoprotein Kinetic, in Patients With Type 2 Diabetes	Unknown status	NCT02721888	Phase 4	Liraglutide;MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)

Search NIH Clinical Center for Liver Disease

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

alglucerase

imiglucerase

Medium chain triglycerides

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Liver Disease cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Liver Disease:

	Adult stem cell therapy for liver insufficiency
	Bone marrow-derived mesenchymal stem cells for treatment of liver failure

Embryonic/Adult Cultured Cells Related to Liver Disease:

	Peripheral blood-derived hematopoietic stem cells PMIDs: 22121493 16556705 18181952
	Bone marrow-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: liver diseases

Sources

Genetic Tests for Liver Disease

Genetic tests related to Liver Disease:

#	Genetic test	Affiliating Genes
1	Hepatic Failure ²⁹
2	Abnormality of the Liver ²⁹

Sources

Anatomical Context for Liver Disease

MalaCards organs/tissues related to Liver Disease:

⁴⁰

Liver, Testes, Kidney, Bone, T Cells, Heart, Endothelial

Sources

Publications for Liver Disease

Articles related to Liver Disease:

(show top 50) (show all 50549)

#	Title	Authors	PMID	Year
1	Liver diseases in COVID-19: Etiology, treatment and prognosis. ⁶¹ ⁴²	Wu J...Li LJ	32476793	2020
2	Alcohol and the Hospitalized Patient. ⁴²	Chernyavsky S...Rizk D	32505260	2020
3	Liver injury in COVID-19: The current evidence. ⁴²	Alqahtani SA...Schattenberg JM	32450787	2020
4	Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease. ⁵⁴ ⁶¹	Fabbrini E...Klein S	20371660	2010
5	Elevated hydroxyacylcarnitines in a carrier of LCHAD deficiency during acute liver disease of pregnancy - a common feature of the pregnancy complication? ⁵⁴ ⁶¹	Eskelin PM...Tyni TA	20363656	2010
6	The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease. ⁵⁴ ⁶¹	Polyzos SA...Tsiaousi E	20415685	2010
7	The spectrum of liver diseases related to ABCB4 gene mutations: pathophysiology and clinical aspects. ⁵⁴ ⁶¹	Davit-Spraul A...Jacquemin E	20422496	2010
8	The PXR is a drug target for chronic inflammatory liver disease. ⁵⁴ ⁶¹	Wallace K...Wright MC	20416375	2010
9	Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis. ⁶¹ ⁵⁴	Lebrec D...Pentocir Group	20102716	2010
10	Nonalcoholic fatty liver disease and HFE gene mutations: a Polish study. ⁵⁴ ⁶¹	Raszeja-Wyszomirska J...Lubinski J	20503453	2010
11	Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice. ⁶¹ ⁵⁴	Marques CM...Mandarim-de-Lacerda CA	20490434	2010
12	Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy. ⁶¹ ⁵⁴	de Piano A...Damaso AR	19942238	2010
13	Is alanine aminotransferase level a surrogate biomarker of hepatic apoptosis in nonalcoholic fatty liver disease? ⁶¹ ⁵⁴	Canbakan B...Ozbay G	20406065	2010
14	Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease. ⁶¹ ⁵⁴	Park H...Okanoue T	19946731	2010
15	Serum apoptotic caspase activity in chronic hepatitis C and nonalcoholic Fatty liver disease. ⁵⁴ ⁶¹	Papatheodoridis GV...Archimandritis AJ	19881359	2010
16	Studies of gamma-glutamyl transferase in alpha-1 antitrypsin deficiency. ⁶¹ ⁵⁴	Holme J...Stockley RA	20397813	2010
17	Effect of Xuezhikang Capsule on serum tumor necrosis factor-alpha and interleukin-6 in patients with nonalcoholic fatty liver disease and hyperlipidemia. ⁵⁴ ⁶¹	Fan XF...Li JP	20473736	2010
18	Nuclear receptors, inflammation, and liver disease: insights for cholestatic and fatty liver diseases. ⁶¹ ⁵⁴	Arrese M...Karpen SJ	20200515	2010
19	Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). ⁶¹ ⁵⁴	Breuker C...Pascussi JM	20185760	2010
20	Nonlinear distribution of adiponectin in patients with nonalcoholic fatty liver disease limits its use in linear regression analysis. ⁵⁴ ⁶¹	Polyzos SA...Zavos C	19770674	2010
21	The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. ⁵⁴ ⁶¹	Schreuder TC...Schaap FG	20093562	2010
22	Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. ⁶¹ ⁵⁴	Petersen KF...Shulman GI	20335584	2010
23	Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. ⁶¹ ⁵⁴	Ix JH...Sharma K	20150538	2010
24	Natural anticoagulants can be useful predictors of severity in chronic liver disease. ⁶¹ ⁵⁴	Abdo AA...Gader AG	20019598	2010
25	HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease. ⁵⁴ ⁶¹	Valenti L...Fargion S	19931264	2010
26	The new therapeutic frontier--nuclear receptors and the liver. ⁶¹ ⁵⁴	Karpen SJ...Trauner M	20133000	2010
27	[Patomechanisms of hepatic steatosis]. ⁵⁴ ⁶¹	Fulop P...Paragh G	20159747	2010
28	Macrophage migration inhibitory factor expression and MIF gene -173 G/C polymorphism in nonalcoholic fatty liver disease. ⁶¹ ⁵⁴	Akyildiz M...Akarca U	19829123	2010
29	Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease. ⁶¹ ⁵⁴	Dongiovanni P...Fargion S	20176643	2010
30	Prevalence of genetic polymorphisms in the promoter region of the alpha-1 antitrypsin (SERPINA1) gene in chronic liver disease: a case control study. ⁶¹ ⁵⁴	Kok KF...Drenth JP	20170533	2010
31	Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease. ⁶¹ ⁵⁴	Oliveira CP...Correa-Giannella ML	19817962	2010
32	[The roles of cyclooxygenase-2 and 5-lipoxygenase in liver disease]. ⁶¹ ⁵⁴	Wang M...Guo JS	20196963	2010
33	Nonalcoholic fatty liver disease in primary aldosteronism: a pilot study. ⁵⁴ ⁶¹	Fallo F...Sechi LA	19910932	2010
34	[Is venous thrombembolism during pregnancy an indication for routine assay of antithrombin activity and antithrombin supplementation?]. ⁶¹ ⁵⁴	Barlik M...Sobieszczyk S	20232702	2010
35	Differential diagnosis of liver diseases using serum biomarkers. ⁵⁴ ⁶¹	Cujic D...Nedic O	20414942	2010
36	Influence of amino-acid polymorphism in the core protein on progression of liver disease in patients infected with hepatitis C virus genotype 1b. ⁶¹ ⁵⁴	Kobayashi M...Kumada H	19950230	2010
37	The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease. ⁵⁴ ⁶¹	Sookoian S...Pirola CJ	19940802	2010
38	Apoptosis in immune-mediated liver diseases. ⁶¹ ⁵⁴	Kahraman A...Canbay A	20460903	2010
39	Therapeutic effect of bezafibrate against biliary damage: a study of phospholipid secretion via the PPARalpha-MDR3 pathway. ⁶¹ ⁵⁴	Nakamuta M...Enjoji M	20040336	2010
40	The role of cytokines in non-alcoholic fatty liver disease. ⁶¹ ⁵⁴	Tilg H	20460908	2010
41	Comparison of modes of prothrombin time reporting in patients with advanced liver disease associated with viral hepatitis. ⁵⁴ ⁶¹	Wei Y...Shi B	19330428	2010
42	Plasma interleukin-18/interleukin-18 binding protein ratio in Chinese with NAFLD. ⁵⁴ ⁶¹	Li Y...Ying W	20422882	2010
43	Animal models for hepatitis C and related liver disease. ⁵⁴ ⁶¹	Koike K...Matsuura Y	20156300	2010
44	Diagnostic role of serum glypican-3 in differentiating hepatocellular carcinoma from non-malignant chronic liver disease and other liver cancers. ⁶¹ ⁵⁴	Tangkijvanich P...Kongtawelert P	19793164	2010
45	Tumor necrosis factor-alpha accelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease. ⁶¹ ⁵⁴	Zhang W...Takahara T	20043871	2010
46	Variants in the UGT1A1 gene and the risk of pediatric nonalcoholic fatty liver disease. ⁵⁴ ⁶¹	Lin YC...Ni YH	19948621	2009
47	Impact of fish oil-based lipid emulsion on serum triglyceride, bilirubin, and albumin levels in children with parenteral nutrition-associated liver disease. ⁶¹ ⁵⁴	Lee SI...Puder M	19687773	2009
48	Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). ⁶¹ ⁵⁴	Mutoh S...Negishi M	19858220	2009
49	[Fatty liver disease, insulin resistance and adiponectin in an obese pediatric population]. ⁵⁴ ⁶¹	Lopez-Capape M...Barrio Castellanos R	19850541	2009
50	Systematic review: caspase-cleaved fragments of cytokeratin 18 - the promises and challenges of a biomarker for chronic liver disease. ⁶¹ ⁵⁴	Yilmaz Y	19769633	2009

Sources

Genes for Liver Disease

Genes related to Liver Disease (0 elite genes):

(show top 50) (show all 108)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MEG3	Maternally Expressed 3	RNA Gene	155	Experimental evidence: Regulation ³⁸ DISEASES inferred ¹⁵	27770549
2	PRKCSH	Protein Kinase C Substrate 80K-H	Protein Coding	54.21	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
3	PKHD1	PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin	Protein Coding	41.96	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Variants (show sections)	15649945 11898128 16199545 (more) 19524688 18407555 10198164 15706593 16897190 19292732 16981847 15108277 17160262
4	SERPINA1	Serpin Family A Member 1	Protein Coding	41.48	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	7606551 9169667 10935704 (more) 17204961 19707397 19961268 1544671 9252072 18955864 2092568 16327507 1562749 12220457 20228200 20090075 19891586 18193338 17044896 15115878 7864587 1871543 17592477 17251342 15674733 15454659 11441335 9447774 20170533 19956452 18294358 17136953 16236857 1760450 7639071 17972336 16814390 15630900 11950825 1594889 10933583 19437508 19827990 15378547 20511674 14594626 16225408
5	GANAB	Glucosidase II Alpha Subunit	Protein Coding	40.79	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
6	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	38.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9750443 10435364 11490825 (more) 15983331 16881537 8573914 9177490 14500044 15297742 15770074 19148354 17512312 16556694 7608477 11039668 15211874 18058413 10389289 7873766 7718965 8780087 11395594 11553266 16549178 16685006 10500955 18763311 17272484 15810122 12569764 1992953 7509301 16810751 18088243 18373563 19686309 1572757 9448172 16682043 17353691 16832839 15767815 14562856 12236486 11776481 11399444 10680318 9453424 8938557 1728920 18205211 17321635 17021358 16254522 15746106 15221058 19370784 18507754 18726958 18484660 18090161 18074733 17701844 17142131 8314470 19966578 20377096 19666428 19502165 19170991 19217453 17517588 17593595 16371533 16166790 12659467 10824882 9727187 9443120 10879229 19849777 20205506 16799164 17063573 16491669 19702910 19293791 18302294 18034825 16249437 16550036 15861019 11911340 15658097 15462195 15235511 12705340 8598105 8655954 8423913 20406065 17255837 17175349 15948897 15705403 15703561 12203077 10459157 9443106 15028636 11129058 9517532 9537867 8155015 10146457 19344244 17764776 1424158 20118733 19779266 17717745 17596883 16955809
7	DLAT	Dihydrolipoamide S-Acetyltransferase	Protein Coding	38.27	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	11851838 17068145
8	ABCB11	ATP Binding Cassette Subfamily B Member 11	Protein Coding	37.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	12536246 14699511 18509747 (more) 20010382
9	PNPLA3	Patatin Like Phospholipase Domain Containing 3	Protein Coding	36.12	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
10	F2	Coagulation Factor II, Thrombin	Protein Coding	35.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10435364 11381464 17924174 (more) 12373814 12654556 15017611 15074396 19460532 9332318 17405283 18469550 20034320 16200238 2147451 1398505 12572711 12950957 20376801 8403694 7771637 8902994 9804483 19334478 10389289 11985056 16274834 16799774 17939263 19330428 15727702 8500713 8135196 15378798 1857606 8888344 9306617 11132456 10733541 12639207 12829902 16623914 10942794 10401942 9846345 8938167 8491449 1333467 19357455 17593061 1544283 20174759 18700988 19954052 19192404 19323033 17162234 16842531 11172350 9322144 7985052 19502165 17580177 17654598 15985009 12824749 11041294 17922457 18221607 17397512 15946135 16623915 12824750 9764985 9352863 9197300 19631411 19502999 10507484 8621137 19689996 8739814 19150311 16220696 15619355 15861019 15368454 11106349 10503834 10850574 10595632 10566732 9819047 9365042 8423913 1578806 1313384 9246040 8148804 8409334 1862252 19560784 19150310 17659574 16615008 16547670 18941414 1672859 7571984 8735313 10479200 15626058
11	PKD1	Polycystin 1, Transient Receptor Potential Channel Interacting	Protein Coding	35.47	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Variants (show sections)	18407555
12	SEC63	SEC63 Homolog, Protein Translocation Regulator	Protein Coding	35.06	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
13	HSD3B7	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 7	Protein Coding	34.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	12679481 17645593
14	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	34.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15983331 1362364 8199687 (more) 15780761 10336050 14500044 19046217 8534650 19943812 1673629 11563810 17512312 19065605 19576874 20397813 1972004 19100265 17379020 8622806 15952086 17352018 1670633 1759330 16120961 16036336 8947881 9589804 11853185 14999694 11129058 9844586 9531115 10920938 8749821 7627819 10146457 17353691 16871999 7522099 7911669 8095247 20021625 19950230 20151095 19131466 18484660 18589096 1983192 20129611 17373869 16799164 15346644 9352863 10879229 1726078 17669242 19839225 19034330 19054785 18369681 18249212 17932318 15552264 11476029 1351699 8844030 20142825 20377096 19666428 17666458 16910310 11940314 18173779 11594118 9443106 7945575 7912266 17353063 12970922 12687334 12501575 11399444 9097279 1672859 16770572 17596883 19686309
15	FAH	Fumarylacetoacetate Hydrolase	Protein Coding	34.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	11209059 7545495 8589717 (more) 8253377 1644288 11196105
16	ALB	Albumin	Protein Coding	34.26	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19597925 15301578 16437641 (more) 10688251 15017611 15074396 8369754 1398505 12572711 8065177 16274834 8364499 1443438 12529398 9923412 9463746 8721905 2330593 11910567 11360736 1986553 15244495 9259139 11018691 12425489 16094905 1670041 15490573 15779582 8500713 12950959 17109498 2293578 18498776 1857606 8445237 15918203 16123966 16952176 18941414 16573786 15765449 15558653 12485604 11804666 9413962 8448071 1572757 16615008 16215894 14752838 11919406 11899506 10388504 9886235 9706886 10146457 1544283 19242728 19192404 17666340 17060879 15576626 12852510 9246040 9322144 1424152 1380023 1916156 20372846 19687773 19918689 19669265 19502165 10087459 9197300 8739814 10879229 7674216 7751582 1962492 2103380 19849777 11400191 19337243 16611186 16047487 15209149 12829985 11586681 10764695 9631834 15770666 12423447 11350035 10595632 10566732 9365042 7491694 8095247 9074791 9286556 8794277 1862252 19686444 19473427 18617764 17955725 1578168 2408218 20430182 19509075 18756471 17471184 17377459 17301654 17681169 16207669 16181370 15710086 10503083
17	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	33.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	18719649 19326095 17006986 (more) 18311774 17379020 19053049 16115302 18376369 15591515 16787375 19850541 18709650 15826715 16231590 17904683 17656035 18854760 19693638 20415685 18713296 19012034 17022944 16139921 19669362 17823431 19525862 17535379 20484835 20022856 19246975 19119485 17196150 15718867 15653112 15369797 19484180 16284427 16279898 16270401 16108051 15797948 19770674 20150538 16231364 16989692 19561788 18565022 19282764 19502655 19585655
18	INS	Insulin	Protein Coding	33.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	14624764 10569299 14620622 (more) 11990393 16799888 18270241 20469672 16339124 19242728 17919242 10543718 19426389 18664869 16565603 16003133 16807517 18924577 18721166 18575782 17986744 16901766 17766001 16989692 16968800 16268963 12197781 19568858 19491421 18854760 17133473 17114290 16225476 15953863 15151626 15122714 19278843 19474742 19464851 17934820 16793619 17599864 16394091 12895270 11832442 19910932 18355813 18397487 17823431 17906183 17203528 15331067 14571229 12779071 20371660 19013572 18654951 17392334 17464461 20159747 19929783 17187615 11753161 19961041 17669243 17324347 17236121 16912563 14610526 14671152 20335584 19072347 18571268 20079327 1296234 10651835 11705130 11822099 11756758 16898568 16762001 18770489 18331185 18591439 18685459 18627005 18503774 17964913 17596883 17311652 2063119 20490434 19946731 20093562 20221393 20156300 20085121 19885351 19525859 19475694
19	LRP5	LDL Receptor Related Protein 5	Protein Coding	32.24	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
20	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	31.86	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8943756 18788383 14500044 (more) 15297742 17575231 19840483 7909270 11233898 16549178 15213895 9046384 15770074 15211874 19542081 15654347 1439189 17669242 15770731 17352018 17379201 18484660 1857606 16770572 20118733 9448172 12677151 14999694 1907676 8727697 15462195 11520257 10609275 1352416 19246126 19478697 10989688 9074791 8593320 10369716 9267545 10879229 1726078 18543598 18302294 16249437 15209149 10927957 19839225 19054785 18445142 18249212 17465456 12792701 10347135 1351699 16799164 16400394 14581797 10824882 7557098 1916663 2171815 20377096 19731022 19666428 17666458 16594470 1667711 19446911 14562856 10680318 20044930 18613423 8888344
21	MARS1	Methionyl-TRNA Synthetase 1	Protein Coding	31.85	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
22	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	31.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	12883487 19307976 12743671 (more) 16380384 11804663 11748356 11804847 9058590 10357784 12569554 16962935 16321567 15670660 9695719 14586387 11071897 7581484 12534643 8563770 15554233 10940340 9927612 7741759 12540792
23	ABCB4	ATP Binding Cassette Subfamily B Member 4	Protein Coding	31.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	20422496 19674157 11745043 (more) 18781607 17295178 20040336
24	TNF	Tumor Necrosis Factor	Protein Coding	31.16	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	11149030 8404274 9047083 (more) 1772964 10681811 19637776 11192323 8927510 18565022 1995437 9127637 18251167 7534321 8225219 8352843 7876386 17509993 15331067 20460908 11199370 8482461 8672758 10091104 11804847 20043871 9514991 11919406 10068094 9238048 19561788 16871999 16344602 15289211 15239085 11324903 10975018 16564703 15929761 14509501 11884933 10331114 9626579 9347083 7509363 16831568 16806222 16545485 12653886 11832442 11816546 9895030 9727645 7612225 2190492 20102716 19575503 19212208 18930330 18190648 17397512 16170395 16279898 12717381 10389289 9590317 8571172 1323602 2121637 19012034 17266151 19201949 18987152 18691193 17823431 16258409 15596091 15059302 9524290 9486175 8801824 8525652 7712914 8090535 8022853 1561525 16938178 2339855 20473736 19629467 19220664 19054267 15601573 15064230 12682890 10068116 8586322 18579335 15041894 10094975
25	KRT18	Keratin 18	Protein Coding	31.11	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	17971926 19769633 17105587 (more) 19587454 16911694 19881359 19707105 18852641 9011570 16575832
26	PKD2	Polycystin 2, Transient Receptor Potential Cation Channel	Protein Coding	30.8	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
27	NR1H4	Nuclear Receptor Subfamily 1 Group H Member 4	Protein Coding	30.2	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	19187229 18668687 14992012 (more) 16706681 19059462 11607932
28	AFP	Alpha Fetoprotein	Protein Coding	30.17	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	1708922 8652249 7691391 (more) 7686444 1707341 1378876 1691611 7516264 9917503 7524830 8894307 7686446 17004260 8520603 11508671 1283927 19469167 10967924 9094031 10626849 15189269 18065642 19062741 18233991 16615008 10365905 10920938 7504252 1377039 1699336 20414942 11205836 11776794 1715601 7691392 18616935 12717392 8884317 8642048 19793164 18658001 17629068 15690478 12788425 15086601 10898315 10554020 9382974 19453644 12143050 9365042 8648260 1285128 8569612 17143948 16273636 16136646 12595973 1712699 20141066 18594985 16871999 12499420 10518313 8985270 12420612 18985745 18638391
29	ATP8B1	ATPase Phospholipid Transporting 8B1	Protein Coding	29.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	12880872 20126555 11745041 (more) 9806540
30	DNAJB11	DnaJ Heat Shock Protein Family (Hsp40) Member B11	Protein Coding	29.24	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
31	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	29.21	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19390649 15382158 18853997 (more) 20040336 16611275 16174475 17244467 17935056 17022944
32	SERPINA3	Serpin Family A Member 3	Protein Coding	29.21	DISEASES inferred ¹⁵ ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries (show sections)	1871543 1315655 2130541
33	ALG8	ALG8 Alpha-1,3-Glucosyltransferase	Protein Coding	29.19	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
34	LEP	Leptin	Protein Coding	29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	19303970 17540037 15582127 (more) 19254460 19858588 17060687 11296700 16231590 16696395 19422483 19693638 12889566 15318105 16249287 20022856 18753993 17062890 9753503 18473416 19012034 18839053 17823431 17509993 15492608 15228881 9514867 15329225 14758566 16989692 18511214
35	KRT8	Keratin 8	Protein Coding	28.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications (show sections)	16911694 11372009 16575832 (more) 16143128 19587454 16365160 15060118 15368451 18329127 17509943 18697208 12724528
36	NDUFB9	NADH:Ubiquinone Oxidoreductase Subunit B9	Protein Coding	28.63	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries Pathways & Interactions (show sections)
37	HGF	Hepatocyte Growth Factor	Protein Coding	27.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9731569 8690730 9548396 (more) 8927623 9214455 11995475 15213896 10220746 1833258 7806142 10594807 8422546 15287857 8414505 8175137 10193310 10385675 11398603 1827761 12907947 10083762 16786119 11860406 7684768 19624764 14696449 10430357 16437717 11264569 11223718 8690400 8179588 1824837 9049198 20372002 8573112 19040928 7489981 8385241 10430302 12472204
38	GOLM1	Golgi Membrane Protein 1	Protein Coding	27.53	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Expressions (show sections)	12029628 15180730
39	NDUFS1	NADH:Ubiquinone Oxidoreductase Core Subunit S1	Protein Coding	26.48	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
40	FAS	Fas Cell Surface Death Receptor	Protein Coding	26.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	18331250 12806430 16856963 (more) 17704785 17979070 19919570 9585233 10737254 10470438 8900539 16510204 9422985 10932156 10950055
41	F3	Coagulation Factor III, Tissue Factor	Protein Coding	26.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12921506 11018691 8902994 (more) 11685041 17654598 10604250 16623914 17593061 7979911 16982303 19330428 20174759 9819047
42	ADIPOR2	Adiponectin Receptor 2	Protein Coding	24.75	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)	17006986
43	HFE	Homeostatic Iron Regulator	Protein Coding	24.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12557137 10692680 16393683 (more) 18201677 11788568 19433916 15991291 17679134 10383365 11495086 20503453 11110619 19931264 12885340 18210110 18438784 16053912 12779071 12401309 9620344 17729389 15566515 11169063 18752323 15508107 12678056 17585191 17573946 16454835 14752836 15304122 10189391 10673304 19115475 15858186 16669553 17362299 17589946 20208481
44	SLC25A13	Solute Carrier Family 25 Member 13	Protein Coding	24.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	18620775 19951499 11281457 (more) 11999983 12424587 16311094
45	ABCB7	ATP Binding Cassette Subfamily B Member 7	Protein Coding	24.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8199687 8266011 11594118 (more) 1350376 7916242
46	CP	Ceruloplasmin	Protein Coding	24.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17688883 15511628 15769390 (more) 9612901 15783020 9207280 15614251 18623632
47	IL6	Interleukin 6	Protein Coding	23.88	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Pathways & Interactions (show sections)
48	ALPP	Alkaline Phosphatase, Placental	Protein Coding	23.75	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	20188823 7909270 16201071 (more) 8617423 1458597 16955809 12970922 12203077 1740521 7665816 9455616 9148865 18585425 19014329 10879229 17903483 18484660 7818774 12394850 16770572
49	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	23.7	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via

Liver Disease

Aliases & Classifications for Liver Disease

MalaCards integrated aliases for Liver Disease:

Classifications:

External Ids:

Summaries for Liver Disease

Related Diseases for Liver Disease

Diseases in the Liver Disease family:

Diseases related to Liver Disease via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Liver Disease via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Liver Disease:

Symptoms & Phenotypes for Liver Disease

UMLS symptoms related to Liver Disease:

MGI Mouse Phenotypes related to Liver Disease:

Drugs & Therapeutics for Liver Disease

Drugs for Liver Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cell-based therapeutics:

Cochrane evidence based reviews: liver diseases

Genetic Tests for Liver Disease

Genetic tests related to Liver Disease:

Anatomical Context for Liver Disease

MalaCards organs/tissues related to Liver Disease:

Publications for Liver Disease

Articles related to Liver Disease:

Genes for Liver Disease

Genes related to Liver Disease (0 elite genes):

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :