LFIT
MCID: LVR030
MIFTS: 40

Liver Failure, Infantile, Transient (LFIT)

Categories: Blood diseases, Bone diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Liver diseases, Mental diseases, Metabolic diseases, Nephrological diseases, Oral diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Liver Failure, Infantile, Transient

MalaCards integrated aliases for Liver Failure, Infantile, Transient:

Name: Liver Failure, Infantile, Transient 57 73 71
Acute Infantile Liver Failure Due to Synthesis Defect of Mtdna-Encoded Proteins 19 58 28 5
Transient Infantile Liver Failure 11 19 14
Acute Infantile Liver Failure Due to Synthesis Defect of Mitochondrial Dna-Encoded Proteins 19 58
Acute Infantile Liver Failure 19 73
Lfit 57 73
Acute Infantile Liver Failure Due to Mtdna-Encoded Proteins Synthesis Defect 73
Failure, Liver, Transient, Infantile 38
Liver Failure, Transient Infantile 57
Liver Failure, Acute Infantile 12

Characteristics:


Inheritance:

Liver Failure, Infantile, Transient: Autosomal recessive 57
Acute Infantile Liver Failure Due to Synthesis Defect of Mtdna-Encoded Proteins: Autosomal recessive 58

Prevelance:

Acute Infantile Liver Failure Due to Synthesis Defect of Mtdna-Encoded Proteins: <1/1000000 (Worldwide) 58

Age Of Onset:

Acute Infantile Liver Failure Due to Synthesis Defect of Mtdna-Encoded Proteins: Infancy,Neonatal 58

OMIM®:

57 (Updated 08-Dec-2022)
Miscellaneous:
onset usually at 2 to 6 months of age
onset at day 1 of life has been reported
clinical improvement after 2 to 3 weeks of supportive care
liver functions return to normal after 3 to 4 months
liver size returns to normal after 3 months to 3 years
those who survive initial acute episode have no recurrence of hepatic involvement, but may have persistent hypotonia


Classifications:

Orphanet: 58  
Rare hepatic diseases
Inborn errors of metabolism


Summaries for Liver Failure, Infantile, Transient

OMIM®: 57 Acute infantile liver failure resulting from TRMU mutation is a transient disorder of hepatic function. In addition to elevated liver enzymes, jaundice, vomiting, coagulopathy, and hyperbilirubinemia, the presence of increased serum lactate is consistent with a defect in mitochondrial respiratory function. With supportive care, patients who survive the initial acute episode can recover and show normal development (Zeharia et al., 2009). See also transient infantile mitochondrial myopathy (MMIT; 500009), which is a similar disorder. A more severe, permanent disorder with some overlapping features is associated with mitochondrial DNA depletion (251880). See ILFS1 (615438) for information on syndromic infantile liver failure. (613070) (Updated 08-Dec-2022)

MalaCards based summary: Liver Failure, Infantile, Transient, also known as acute infantile liver failure due to synthesis defect of mtdna-encoded proteins, is related to infantile liver failure syndrome and spinocerebellar ataxia, autosomal recessive 21, and has symptoms including vomiting and icterus. An important gene associated with Liver Failure, Infantile, Transient is TRMU (TRNA Mitochondrial 2-Thiouridylase), and among its related pathways/superpathways is tRNA-uridine 2-thiolation (mammalian mitochondria). Affiliated tissues include liver and skin, and related phenotypes are hepatomegaly and feeding difficulties in infancy

GARD: 19 Acute infantile liver failure resulting from TRMU mutation is a transient disorder of hepatic function. In addition to elevated liver enzymes, jaundice, vomiting, coagulopathy, and hyperbilirubinemia, the presence of increased serum lactate is consistent with a defect in mitochondrial respiratory function. With supportive care, patients who survive the initial acute episode can recover and show normal development (Zeharia et al., 2009).See also transient infantile mitochondrial myopathy (MMIT; 500009), which is a similar disorder.A more severe, permanent disorder with some overlapping features is associated with mitochondrial DNA depletion (251880).See ILFS1 (615438) for information on syndromic infantile liver failure.

Disease Ontology: 11 A liver disease that is characterized by elevated liver enzymes, jaundice, vomiting, coagulopathy, and hyperbilirubinemia, and the presence of increased serum lactate and that has material basis in homozygous or compound heterozygous mutation in the TRMU gene, which is involved in mitochondrial protein translation, on chromosome 22q13.

UniProtKB/Swiss-Prot: 73 A transient disorder of hepatic function characterized by elevated liver enzymes, jaundice, vomiting, coagulopathy, hyperbilirubinemia, increased serum lactate. Patients who survive the initial acute episode can recover, show normal development and have no recurrence.

Orphanet: 58 A rare mitochondrial respiratory chain deficiency due to TRMU deficiency leading to mitochondrial tRNA synthesis defect and characterized clinically by transient, but life-threatening acute liver failure episodes.

Related Diseases for Liver Failure, Infantile, Transient

Diseases in the Liver Disease family:

Liver Failure, Infantile, Transient Infantile Liver Failure Syndrome 1
Infantile Liver Failure Syndrome 2 Infantile Liver Failure Syndrome 3
Liver Disease, Severe Congenital Infantile Liver Failure Syndrome
Acute Liver Failure

Diseases related to Liver Failure, Infantile, Transient via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 infantile liver failure syndrome 30.1 NBAS LARS1
2 spinocerebellar ataxia, autosomal recessive 21 11.6
3 infantile liver failure syndrome 1 11.5
4 fever-associated acute infantile liver failure syndrome 11.5
5 mitochondrial myopathy, infantile, transient 11.0
6 mitochondrial complex i deficiency, nuclear type 33 10.0 TUBGCP6 TRMU
7 hemochromatosis, type 1 10.0
8 non-alcoholic fatty liver disease 10.0
9 liver disease 10.0
10 acute liver failure 10.0
11 myoclonic epilepsy associated with ragged-red fibers 10.0 TRMU LARS1
12 queensland tick typhus 10.0 TRMU MTO1
13 myopathy, lactic acidosis, and sideroblastic anemia 2 10.0 TRMU MTO1
14 cardiomyopathy, infantile hypertrophic 9.9 TRMU MTO1
15 charcot-marie-tooth disease, type 4b3 9.9 TUBGCP6 SBF1
16 early myoclonic encephalopathy 9.8 TRMU MTO1
17 skin hemangioma 9.8 NAGA A4GALT
18 angiokeratoma 9.7 NAGA A4GALT
19 combined oxidative phosphorylation deficiency 10 9.7 TRMU SBF1 MTO1
20 schindler disease 9.7 TUBGCP6 SBF1 NAGA
21 sphingolipidosis 9.7 NAGA A4GALT
22 mitochondrial encephalomyopathy 9.7 TRMU MTO1
23 fabry disease 9.6 NAGA A4GALT

Graphical network of the top 20 diseases related to Liver Failure, Infantile, Transient:



Diseases related to Liver Failure, Infantile, Transient

Symptoms & Phenotypes for Liver Failure, Infantile, Transient

Human phenotypes related to Liver Failure, Infantile, Transient:

30 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hepatomegaly 30 Very rare (1%) HP:0002240
2 feeding difficulties in infancy 30 Very rare (1%) HP:0008872
3 vomiting 30 Very rare (1%) HP:0002013
4 irritability 30 Very rare (1%) HP:0000737
5 jaundice 30 Very rare (1%) HP:0000952
6 increased serum lactate 30 Very rare (1%) HP:0002151
7 hyperbilirubinemia 30 Very rare (1%) HP:0002904
8 hypoalbuminemia 30 Very rare (1%) HP:0003073
9 prolonged prothrombin time 30 Very rare (1%) HP:0008151
10 abdominal distention 30 Very rare (1%) HP:0003270
11 acute hepatic failure 30 Very rare (1%) HP:0006554
12 decreased circulating igg level 30 Very rare (1%) HP:0004315
13 mitochondrial respiratory chain defects 30 Very rare (1%) HP:0200125
14 macrovesicular hepatic steatosis 30 Very rare (1%) HP:0001403
15 lacticaciduria 30 Very rare (1%) HP:0003648
16 elevated circulating alanine aminotransferase concentration 30 Very rare (1%) HP:0031964
17 3-hydroxydicarboxylic aciduria 30 Very rare (1%) HP:0008160
18 elevated hepatic transaminase 30 HP:0002910
19 lactic acidosis 30 HP:0003128
20 generalized hypotonia 30 HP:0001290
21 microvesicular hepatic steatosis 30 HP:0001414

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Muscle Soft Tissue:
hypotonia
cox-depleted fibers

Abdomen Gastrointestinal:
vomiting
poor feeding

Laboratory Abnormalities:
increased serum lactate
abnormal liver enzymes
hyperbilirubinemia, direct
decreased serum albumin
increased alpha-fetoprotein

Abdomen External Features:
distended abdomen

Abdomen Liver:
hepatomegaly
jaundice
cholestasis
mitochondrial respiratory chain defects
microvesicular steatosis
more
Skin Nails Hair Skin:
jaundice
pale-gray skin

Metabolic Features:
lactic acidosis

Hematology:
coagulopathy secondary to liver failure

Clinical features from OMIM®:

613070 (Updated 08-Dec-2022)

UMLS symptoms related to Liver Failure, Infantile, Transient:


vomiting; icterus

Drugs & Therapeutics for Liver Failure, Infantile, Transient

Search Clinical Trials, NIH Clinical Center for Liver Failure, Infantile, Transient

Genetic Tests for Liver Failure, Infantile, Transient

Genetic tests related to Liver Failure, Infantile, Transient:

# Genetic test Affiliating Genes
1 Acute Infantile Liver Failure Due to Synthesis Defect of Mtdna-Encoded Proteins 28 TRMU

Anatomical Context for Liver Failure, Infantile, Transient

Organs/tissues related to Liver Failure, Infantile, Transient:

MalaCards : Liver, Skin

Publications for Liver Failure, Infantile, Transient

Articles related to Liver Failure, Infantile, Transient:

(show all 25)
# Title Authors PMID Year
1
Acute infantile liver failure due to mutations in the TRMU gene. 62 57 5
19732863 2009
2
Reversible infantile respiratory chain deficiency is a unique, genetically heterogenous mitochondrial disease. 57 5
21931168 2011
3
Hepatic Copper Accumulation: A Novel Feature in Transient Infantile Liver Failure Due to TRMU Mutations? 62 5
25665837 2015
4
Defining clinical subgroups and genotype-phenotype correlations in NBAS-associated disease across 110 patients. 5
31761904 2020
5
Complex Multisystem Phenotype With Immunodeficiency Associated With NBAS Mutations: Reports of Three Patients and Review of the Literature. 5
33042920 2020
6
Diagnostic Yield of an Algorithm for Neonatal and Infantile Cholestasis Integrating Next-Generation Sequencing. 5
31160058 2019
7
Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts. 5
26541327 2016
8
Mitochondrial Infantile Liver Disease due to TRMU Gene Mutations: Three New Cases. 5
23625533 2013
9
Reversible fulminant lactic acidosis and liver failure in an infant with hepatic cytochrome-c oxidase deficiency. 57
12408186 2002
10
Using feeding and motility patterns for ivermectin resistance detecting in Haemonchus contortus larvae. 62
35151652 2022
11
Stainless Steel Femoral Heads Reduce Rate of Revision When Compared to Ion-Implanted Chromium-Cobalt Heads With a Single Cemented Femoral Design: An Analysis of 40,468 Total Hip Replacements From the Australian Orthopedic Association National Joint Replacement Registry. 62
34521567 2021
12
A new method of contrast enhancement of musculoskeletal ultrasound imaging based on fuzzy inference technique. 62
34161931 2021
13
Bilateral Mechanically-Assisted Crevice Corrosion Resulting in Femoral Stem-Head Dissociation in Metal-on-Polyethylene Total Hip Arthroplasty. 62
33718553 2021
14
TRMU deficiency: A broad clinical spectrum responsive to cysteine supplementation. 62
33485800 2021
15
Catastrophic failure of the Accolade I hip arthroplasty stem: a retrieval analysis study. 62
32323587 2020
16
Head Taper Corrosion Causing Head Bottoming Out and Consecutive Gross Stem Taper Failure in Total Hip Arthroplasty. 62
30100136 2018
17
Trunnion Failure of the Recalled Low Friction Ion Treatment Cobalt Chromium Alloy Femoral Head. 62
28478184 2017
18
Preparation and evaluation of Salmonella Enteritidis antigen conjugated with nanogold for screening of poultry flocks. 62
28919672 2017
19
Biallelic Mutations in NBAS Cause Recurrent Acute Liver Failure with Onset in Infancy. 62
26073778 2015
20
Energy compensation after an aerobic exercise session in high-fat/low-fit and low-fat/high-fit young male subjects. 62
23506960 2013
21
Impact of technical training on rapid antigen detection tests (RADT) in group A streptococcal tonsillopharyngitis. 62
23207649 2013
22
Cardiovascular fitness and mortality after contemporary cardiac rehabilitation. 62
23639499 2013
23
Action of sisal (Agave sisalana, Perrine) extract in the in vitro development of sheep and goat gastrointestinal nematodes. 62
22469785 2012
24
In vitro screening of plant lectins and tropical plant extracts for anthelmintic properties. 62
22130336 2012
25
The 2-thiouridylase function of the human MTU1 (TRMU) enzyme is dispensable for mitochondrial translation. 62
21890497 2011

Variations for Liver Failure, Infantile, Transient

ClinVar genetic disease variations for Liver Failure, Infantile, Transient:

5 (show top 50) (show all 132)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TRMU NM_018006.5(TRMU):c.229T>C (p.Tyr77His) SNV Pathogenic
1291 rs118203990 GRCh37: 22:46733822-46733822
GRCh38: 22:46337925-46337925
2 TRMU NM_018006.5(TRMU):c.815G>A (p.Gly272Asp) SNV Pathogenic
1293 rs118203991 GRCh37: 22:46749706-46749706
GRCh38: 22:46353809-46353809
3 TRMU NM_018006.5(TRMU):c.2T>A (p.Met1Lys) SNV Pathogenic
1294 rs118203992 GRCh37: 22:46731663-46731663
GRCh38: 22:46335766-46335766
4 TRMU NM_018006.5(TRMU):c.954dup (p.Ala319fs) DUP Pathogenic
215294 rs863224242 GRCh37: 22:46751418-46751419
GRCh38: 22:46355521-46355522
5 TRMU NM_018006.5(TRMU):c.117G>A (p.Trp39Ter) SNV Pathogenic
856245 rs1174791046 GRCh37: 22:46733710-46733710
GRCh38: 22:46337813-46337813
6 TRMU NM_018006.5(TRMU):c.718C>T (p.Arg240Ter) SNV Pathogenic
215287 rs367683258 GRCh37: 22:46748173-46748173
GRCh38: 22:46352276-46352276
7 TRMU NM_018006.5(TRMU):c.706-1G>A SNV Pathogenic
1076499 GRCh37: 22:46748160-46748160
GRCh38: 22:46352263-46352263
8 TRMU NM_018006.5(TRMU):c.1102-3C>G SNV Pathogenic/Likely Pathogenic
427012 rs753039116 GRCh37: 22:46752736-46752736
GRCh38: 22:46356839-46356839
9 TRMU NM_018006.5(TRMU):c.835G>A (p.Val279Met) SNV Pathogenic/Likely Pathogenic
30819 rs387907022 GRCh37: 22:46749726-46749726
GRCh38: 22:46353829-46353829
10 LARS1 NM_020117.11(LARS1):c.2770-2A>G SNV Likely Pathogenic
1343775 GRCh37: 5:145508347-145508347
GRCh38: 5:146128784-146128784
11 NBAS NC_000002.11:g.(15567919_15601324)_(15618414_15629017)del DEL Likely Pathogenic
1677070 GRCh37: 2:15567919-15629017
GRCh38:
12 NBAS NC_000002.11:g.(15378811_15415607)_(15567919_15601324)del DEL Likely Pathogenic
1683354 GRCh37: 2:15378811-15601324
GRCh38:
13 TRMU NM_018006.5(TRMU):c.1258_1259dup (p.Leu420fs) DUP Likely Pathogenic
1687728 GRCh37: 22:46752894-46752895
GRCh38: 22:46356997-46356998
14 NBAS NM_015909.4(NBAS):c.1A>T (p.Met1Leu) SNV Likely Pathogenic
1696343 GRCh37: 2:15701428-15701428
GRCh38: 2:15561304-15561304
15 NBAS NM_015909.4(NBAS):c.1213C>T (p.Arg405Ter) SNV Likely Pathogenic
1335898 GRCh37: 2:15615939-15615939
GRCh38: 2:15475815-15475815
16 TRMU NM_018006.5(TRMU):c.880del (p.Arg294fs) DEL Likely Pathogenic
558684 rs1490906786 GRCh37: 22:46751342-46751342
GRCh38: 22:46355445-46355445
17 NBAS NM_015909.4(NBAS):c.6877del (p.Leu2293fs) DEL Likely Pathogenic
1217235 GRCh37: 2:15307411-15307411
GRCh38: 2:15167287-15167287
18 NBAS NM_015909.4(NBAS):c.6909T>A (p.Cys2303Ter) SNV Likely Pathogenic
1331491 GRCh37: 2:15307379-15307379
GRCh38: 2:15167255-15167255
19 TRMU NM_018006.5(TRMU):c.758T>C (p.Leu253Pro) SNV Likely Pathogenic
217019 rs766314948 GRCh37: 22:46748213-46748213
GRCh38: 22:46352316-46352316
20 TRMU NM_018006.5(TRMU):c.653G>T (p.Ser218Ile) SNV Likely Pathogenic
807715 rs1601977105 GRCh37: 22:46748019-46748019
GRCh38: 22:46352122-46352122
21 TRMU NM_018006.5(TRMU):c.249-2A>G SNV Likely Pathogenic
1067268 GRCh37: 22:46739157-46739157
GRCh38: 22:46343260-46343260
22 NBAS NC_000002.11:g.(15432891_15448339)_(15449372_15467873)del DEL Likely Pathogenic
1705204 GRCh37: 2:15432891-15467873
GRCh38:
23 TRMU NM_018006.5(TRMU):c.873+1G>C SNV Likely Pathogenic
1704580 GRCh37: 22:46749765-46749765
GRCh38: 22:46353868-46353868
24 TRMU NM_018006.5(TRMU):c.882del (p.Thr295fs) DEL Likely Pathogenic
1704581 GRCh37: 22:46751348-46751348
GRCh38: 22:46355451-46355451
25 LARS1 NM_020117.11(LARS1):c.1755G>A (p.Trp585Ter) SNV Likely Pathogenic
1723363 GRCh37: 5:145523097-145523097
GRCh38: 5:146143534-146143534
26 NBAS NC_000002.11:g.(15470890_15492115)_(15493835_15496426)del DEL Likely Pathogenic
1723387 GRCh37: 2:15470890-15496426
GRCh38:
27 TRMU NM_018006.5(TRMU):c.680G>C (p.Arg227Thr) SNV Likely Pathogenic
973463 rs764622793 GRCh37: 22:46748046-46748046
GRCh38: 22:46352149-46352149
28 NBAS NM_015909.4(NBAS):c.2764-1G>C SNV Likely Pathogenic
1722434 GRCh37: 2:15555844-15555844
GRCh38: 2:15415720-15415720
29 NBAS NM_015909.4(NBAS):c.4698_4741del (p.Ser1567fs) DEL Likely Pathogenic
1722435 GRCh37: 2:15448396-15448439
GRCh38: 2:15308272-15308315
30 LARS1 NM_020117.11(LARS1):c.661C>T (p.Gln221Ter) SNV Likely Pathogenic
1722447 GRCh37: 5:145539983-145539983
GRCh38: 5:146160420-146160420
31 TRMU NM_018006.5(TRMU):c.1073_1081dup (p.Gln358_Val360dup) DUP Conflicting Interpretations Of Pathogenicity
552491 rs753112330 GRCh37: 22:46751933-46751934
GRCh38: 22:46356036-46356037
32 TRMU NM_018006.5(TRMU):c.834C>T (p.Tyr278=) SNV Uncertain Significance
797650 rs772935887 GRCh37: 22:46749725-46749725
GRCh38: 22:46353828-46353828
33 TRMU NM_018006.5(TRMU):c.83-9C>T SNV Uncertain Significance
990755 rs374612111 GRCh37: 22:46733667-46733667
GRCh38: 22:46337770-46337770
34 TRMU NM_018006.5(TRMU):c.82+8G>A SNV Uncertain Significance
766086 rs1601929107 GRCh37: 22:46731751-46731751
GRCh38: 22:46335854-46335854
35 TRMU NM_018006.5(TRMU):c.83-5C>T SNV Uncertain Significance
797583 rs758628820 GRCh37: 22:46733671-46733671
GRCh38: 22:46337774-46337774
36 TRMU NM_018006.5(TRMU):c.1018+9C>T SNV Uncertain Significance
342015 rs373346869 GRCh37: 22:46751494-46751494
GRCh38: 22:46355597-46355597
37 TRMU NM_018006.5(TRMU):c.773-4G>A SNV Uncertain Significance
899871 rs368787983 GRCh37: 22:46749660-46749660
GRCh38: 22:46353763-46353763
38 TRMU NM_018006.5(TRMU):c.954C>T (p.Pro318=) SNV Uncertain Significance
500143 rs758271660 GRCh37: 22:46751421-46751421
GRCh38: 22:46355524-46355524
39 TRMU NM_018006.5(TRMU):c.238G>A (p.Asp80Asn) SNV Uncertain Significance
215284 rs55952751 GRCh37: 22:46733831-46733831
GRCh38: 22:46337934-46337934
40 TRMU NM_018006.5(TRMU):c.289C>T (p.Pro97Ser) SNV Uncertain Significance
283815 rs886042713 GRCh37: 22:46739199-46739199
GRCh38: 22:46343302-46343302
41 TRMU NM_018006.5(TRMU):c.1135G>T (p.Gly379Cys) SNV Uncertain Significance
193910 rs773023974 GRCh37: 22:46752772-46752772
GRCh38: 22:46356875-46356875
42 TRMU NM_018006.4(TRMU):c.-281G>A SNV Uncertain Significance
341991 rs148373924 GRCh37: 22:46731381-46731381
GRCh38: 22:46335484-46335484
43 TRMU NM_018006.4(TRMU):c.-113G>C SNV Uncertain Significance
342000 rs182529223 GRCh37: 22:46731549-46731549
GRCh38: 22:46335652-46335652
44 TRMU NM_018006.4(TRMU):c.-147C>A SNV Uncertain Significance
341997 rs190351151 GRCh37: 22:46731515-46731515
GRCh38: 22:46335618-46335618
45 TRMU NM_018006.5(TRMU):c.1218C>T (p.Ser406=) SNV Uncertain Significance
342019 rs754239335 GRCh37: 22:46752855-46752855
GRCh38: 22:46356958-46356958
46 TRMU NM_018006.4(TRMU):c.-279G>A SNV Uncertain Significance
341992 rs187162795 GRCh37: 22:46731383-46731383
GRCh38: 22:46335486-46335486
47 TRMU NM_018006.4(TRMU):c.-161A>C SNV Uncertain Significance
341995 rs886057607 GRCh37: 22:46731501-46731501
GRCh38: 22:46335604-46335604
48 TRMU NM_018006.4(TRMU):c.-151G>A SNV Uncertain Significance
341996 rs886057608 GRCh37: 22:46731511-46731511
GRCh38: 22:46335614-46335614
49 TRMU NM_018006.4(TRMU):c.-190A>T SNV Uncertain Significance
341993 rs538113553 GRCh37: 22:46731472-46731472
GRCh38: 22:46335575-46335575
50 TRMU NM_018006.4(TRMU):c.-87T>C SNV Uncertain Significance
342001 rs184994382 GRCh37: 22:46731575-46731575
GRCh38: 22:46335678-46335678

UniProtKB/Swiss-Prot genetic disease variations for Liver Failure, Infantile, Transient:

73
# Symbol AA change Variation ID SNP ID
1 TRMU p.Tyr77His VAR_063429 rs118203990
2 TRMU p.Gly272Asp VAR_063430 rs118203991

Expression for Liver Failure, Infantile, Transient

Search GEO for disease gene expression data for Liver Failure, Infantile, Transient.

Pathways for Liver Failure, Infantile, Transient

Pathways related to Liver Failure, Infantile, Transient according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.23 TRMU MTO1

GO Terms for Liver Failure, Infantile, Transient

Biological processes related to Liver Failure, Infantile, Transient according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tRNA processing GO:0008033 8.62 TRMU MTO1

Sources for Liver Failure, Infantile, Transient

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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