Liver Leiomyoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Liver Leiomyoma

MalaCards integrated aliases for Liver Leiomyoma:

Name: Liver Leiomyoma ¹¹ ¹⁴ ⁷¹

Leiomyoma of the Liver ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Liver diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:917

NCIt ⁴⁹ C5753

UMLS ⁷¹ C1333968

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Summaries for Liver Leiomyoma

MalaCards based summary: Liver Leiomyoma, also known as leiomyoma of the liver, is related to leiomyoma and small intestinal sarcoma. An important gene associated with Liver Leiomyoma is ANO1 (Anoctamin 1), and among its related pathways/superpathways are Signaling by Receptor Tyrosine Kinases and NF-kappaB Signaling. Affiliated tissues include liver and smooth muscle, and related phenotypes are neoplasm and muscle

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Related Diseases for Liver Leiomyoma

Diseases related to Liver Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 436)

#	Related Disease	Score	Top Affiliating Genes
1	leiomyoma	29.5	PGR KIT ESR1 CD34
2	small intestinal sarcoma	10.3	KIT ANO1
3	gastric leiomyosarcoma	10.3	KIT ANO1
4	gallbladder leiomyoma	10.3	KIT CD34
5	spinal cord sarcoma	10.3	KIT CD34
6	breast hemangiopericytoma	10.3	KIT CD34
7	neuronal intestinal dysplasia, type b	10.3	KIT CD34
8	sclerosing liposarcoma	10.3	KIT CD34
9	bilateral hypoactive labyrinth	10.3	KIT ANO1
10	gastric teratoma	10.3	KIT AFP
11	retroperitoneal hemangiopericytoma	10.3	KIT CD34
12	mediastinum seminoma	10.3	KIT AFP
13	sarcomatous intrahepatic cholangiocarcinoma	10.3	ANO1 AFP
14	epithelial-myoepithelial carcinoma	10.3	KIT ANO1
15	testicular gonadoblastoma	10.3	KIT AFP
16	sarcomatoid renal cell carcinoma	10.3	KIT CD34
17	pineal region teratoma	10.3	KIT AFP
18	extragonadal seminoma	10.3	KIT AFP
19	lipoma of spermatic cord	10.3	ANO1 AFP
20	ovarian solid teratoma	10.3	CD34 AFP
21	mixed liposarcoma	10.3	KIT CD34
22	paratesticular lipoma	10.3	ANO1 AFP
23	intratubular embryonal carcinoma	10.3	KIT AFP
24	thymus adenocarcinoma	10.3	KIT CEACAM5
25	middle ear cholesterol granuloma	10.2	CEACAM5 CD34
26	adenoid basal cell carcinoma	10.2	KIT CEACAM5
27	thymus large cell carcinoma	10.2	KIT CR2
28	active peptic ulcer disease	10.2	KIT ANO1
29	cutaneous ganglioneuroma	10.2	KIT CD34
30	peliosis hepatis	10.2	CD34 AFP
31	malignant mesenchymoma	10.2	CD34 AFP
32	endometrial small cell carcinoma	10.2	KIT AFP
33	ovarian fetiform teratoma	10.2	CEACAM5 AFP
34	meckel diverticulum	10.2	KIT CD34
35	mucinous cystadenocarcinoma	10.2	CEACAM5 AFP
36	pulmonary vein leiomyosarcoma	10.2	PGR CD34
37	immature teratoma of ovary	10.2	CEACAM5 AFP
38	uterus leiomyosarcoma	10.2	PGR KIT
39	malignant syringoma	10.2	CEACAM5 CD34
40	lung meningioma	10.2	PGR CD34
41	parovarian cyst	10.2	CEACAM5 AFP
42	adult malignant schwannoma	10.2	KIT CD34
43	tibial adamantinoma	10.2	KIT CD34
44	brain germinoma	10.2	KIT AFP
45	rectum signet ring adenocarcinoma	10.2	CEACAM5 AFP
46	liver lymphoma	10.2	CEACAM5 AFP
47	acute basophilic leukemia	10.2	KIT CD34
48	psammomatous meningioma	10.2	PGR CD34
49	adult teratoma	10.2	CEACAM5 AFP
50	bile duct cystadenoma	10.2	CEACAM5 CD34

Graphical network of the top 20 diseases related to Liver Leiomyoma:

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Symptoms & Phenotypes for Liver Leiomyoma

MGI Mouse Phenotypes related to Liver Leiomyoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.7	AFP ALK CD34 CEACAM5 ESR1 KIT
2	muscle	MP:0005369	9.43	ANO1 CEACAM5 ESR1 KIT PECAM1 PGR
3	homeostasis/metabolism	MP:0005376	9.32	AFP ALK ANO1 CD34 CEACAM5 CR2

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Drugs & Therapeutics for Liver Leiomyoma

Search Clinical Trials, NIH Clinical Center for Liver Leiomyoma

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Genetic Tests for Liver Leiomyoma

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Anatomical Context for Liver Leiomyoma

Organs/tissues related to Liver Leiomyoma:

MalaCards : Liver, Smooth Muscle

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Publications for Liver Leiomyoma

Articles related to Liver Leiomyoma:

(show all 24)

#	Title	Authors	PMID	Year
1	Primary leiomyoma of the liver in an immunocompetent patient. ⁶²	Coletta D...Grazi GL	33139985	2020
2	Primary Leiomyoma of the Liver: Case Report and Review of the Literature. ⁶²	Navarro C...Sangster G	27159457	2015
3	Primary myxoid leiomyoma of the liver. ⁶²	Choi HS...Park S	24627696	2014
4	Primary leiomyoma of the liver: a review of a rare tumour. ⁶²	Omiyale AO	25505821	2014
5	Epstein-Barr virus negative primary hepatic leiomyoma: case report and literature review. ⁶²	Luo XZ...Gong NQ	23840159	2013
6	Primary liver leiomyoma: a review of this unusual tumour. ⁶²	Perini MV...Christophi C	22984931	2013
7	Primary leiomyoma of the liver: accurate preoperative diagnosis on liver biopsy. ⁶²	Sousa HT...Leitao MC	21686574	2009
8	Gadobenate dimeglumine-enhanced magnetic resonance imaging of primary leiomyoma of the liver. ⁶²	Marin D...Passariello R	18777536	2008
9	Primary leiomyoma of the liver: report of a case. ⁶²	Urizono Y...Nakajima Y	16794799	2006
10	[Primary leiomyoma of the liver: a case report]. ⁶²	Imasato M...Monden T	16304825	2005
11	[Primary leiomyoma of the liver: a rare benign tumor]. ⁶²	Beuzen F...Smadja C	15657544	2004
12	A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression. ⁶²	Kanazawa N...Sakai T	12243795	2002
13	Hepatic resection for primary giant leiomyoma of the liver. ⁶²	Belli G...Marano I	18333008	2001
14	Primary leiomyoma of the liver. ⁶²	Mesenas SJ...Ng HS	11063198	2000
15	Primary myxoid leiomyoma of the liver. ⁶²	Yoon GS...Kim OJ	9870862	1998
16	Epstein-Barr virus-associated hepatic smooth muscle neoplasm in a cardiac transplant recipient. ⁶²	Davidoff AM...Lau HT	8610372	1996
17	[Primary leiomyoma of the liver]. ⁶²	Shiraki K...Tameda Y	8749517	1995
18	Primary leiomyoma of the liver. A case report and review of the literature. ⁶²	Reinertson TE...Balint JA	1551357	1992
19	[Primary hepatic leiomyoma]. ⁶²	Bartoli S...Thau A	1961607	1991
20	Primary leiomyoma of the liver. ⁶²	Herzberg AJ...Meyers WC	2252034	1990
21	A leiomyoma of the liver. ⁶²	Hollands MJ...Little JM	2487073	1989
22	Mortality, major cause of moribundity, and spontaneous tumors in CD-1 mice. ⁶²	Maita K...Inui K	3194656	1988
23	Primary leiomyoma of the liver. Successful treatment by lobectomy and presentation of criteria for diagnosis. ⁶²	Hawkins EP...McGavran MH	7396072	1980
24	LEIOMYOMA OF THE LIVER. ⁶²	RIOS-DALENZ JL	14219531	1965

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Genes for Liver Leiomyoma

Genes related to Liver Leiomyoma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ANO1	Anoctamin 1	Protein Coding	5.13	DISEASES inferred ¹⁴
2	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	5.08	DISEASES inferred ¹⁴
3	CD34	CD34 Molecule	Protein Coding	4.56	DISEASES inferred ¹⁴
4	CR2	Complement C3d Receptor 2	Protein Coding	4.52	DISEASES inferred ¹⁴
5	AFP	Alpha Fetoprotein	Protein Coding	4.29	DISEASES inferred ¹⁴
6	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.23	DISEASES inferred ¹⁴
7	PGR	Progesterone Receptor	Protein Coding	3.92	DISEASES inferred ¹⁴
8	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	3.63	DISEASES inferred ¹⁴
9	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	3.63	DISEASES inferred ¹⁴
10	CALB2	Calbindin 2	Protein Coding	3.18	DISEASES inferred ¹⁴
11	ESR1	Estrogen Receptor 1	Protein Coding	3.12	DISEASES inferred ¹⁴

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Variations for Liver Leiomyoma

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Expression for Liver Leiomyoma

Search GEO for disease gene expression data for Liver Leiomyoma.

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Pathways for Liver Leiomyoma

Pathways related to Liver Leiomyoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.34	PGR KIT ESR1 ALK
2	NF-kappaB Signaling ³	11.44	PECAM1 KIT CEACAM5 CD34
3	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.2	KIT CEACAM5 CD34
4	Cellular roles of Anthrax toxin ⁶¹	10.54	PGR ESR1
5	Mammary gland development pathway - Puberty (Stage 2 of 4) ⁷⁴	10.27	PGR ESR1

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GO Terms for Liver Leiomyoma

Cellular components related to Liver Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.58	PECAM1 KIT CEACAM5 CD34 ANO1 ALK
2	plasma membrane	GO:0005887	9.58	PECAM1 KIT CEACAM5 CD34 ANO1 ALK

Biological processes related to Liver Leiomyoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.62	PGR ESR1
2	positive regulation of phospholipase C activity	GO:0010863	9.56	KIT ESR1
3	ovulation from ovarian follicle	GO:0001542	9.46	PGR AFP
4	paracrine signaling	GO:0038001	9.26	PGR CD34
5	glomerular endothelium development	GO:0072011	8.92	PECAM1 CD34

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Sources for Liver Leiomyoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: LVR005 MIFTS: 27	Liver Leiomyoma Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases	Data Licensing For inquiries, contact: [email protected]
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