MCID: LVR010
MIFTS: 30

Liver Leiomyosarcoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases
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Aliases & Classifications for Liver Leiomyosarcoma

MalaCards integrated aliases for Liver Leiomyosarcoma:

Name: Liver Leiomyosarcoma 11 14 71
Leiomyosarcoma of the Liver 11

Classifications:



External Ids:

Disease Ontology 11 DOID:5296
NCIt 49 C5756
UMLS 71 C1333969

Summaries for Liver Leiomyosarcoma

Disease Ontology: 11 A leiomyosarcoma and sarcoma of liver that is located in the liver.

MalaCards based summary: Liver Leiomyosarcoma, also known as leiomyosarcoma of the liver, is related to epithelioid leiomyosarcoma and gastric leiomyosarcoma. An important gene associated with Liver Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include liver, smooth muscle and spleen, and related phenotypes are Strongly decreased CFP-tsO45G cell surface transport and muscle

Related Diseases for Liver Leiomyosarcoma

Diseases related to Liver Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 489)
# Related Disease Score Top Affiliating Genes
1 epithelioid leiomyosarcoma 30.4 KIT CD34 CALD1 ANO1
2 gastric leiomyosarcoma 30.4 KIT CALD1 ANO1
3 leiomyosarcoma 30.2 WT1 PSMB9 KIT
4 alcohol use disorder 29.8 GPT F2 ALB AFP
5 intrahepatic cholangiocarcinoma 29.7 GPC3 CEACAM5 ALB AFP
6 teratoma 29.7 KIT CHGA CEACAM5 CALB2 AFP
7 smooth muscle tumor 29.6 KIT CR2 CD34 CALD1 ANO1
8 sarcoma 28.9 WT1 KIT CR2 CD163 CALB2
9 bladder leiomyoma 10.4 KIT CALD1
10 urethra leiomyoma 10.4 KIT CALD1
11 ureter leiomyoma 10.4 KIT CALD1
12 kidney leiomyosarcoma 10.4 CALD1 ANO1
13 esophagus sarcoma 10.4 KIT CALD1
14 fallopian tube benign neoplasm 10.4 CALD1 AFP
15 mediastinum seminoma 10.4 KIT AFP
16 intravascular angioleiomyoma 10.4 CD34 CALD1
17 vagina leiomyosarcoma 10.4 KIT CALD1
18 uterine corpus sarcoma 10.4 KIT CALD1
19 gallbladder leiomyoma 10.4 KIT CD34
20 bartholin's duct cyst 10.4 CD34 CALD1
21 pulmonary vein leiomyosarcoma 10.4 CD34 CALD1
22 spinal cord sarcoma 10.4 KIT CD34
23 conventional fibrosarcoma 10.4 CD34 CALD1
24 conventional leiomyosarcoma 10.4 CALD1 ANO1
25 breast hemangiopericytoma 10.4 KIT CD34
26 diffuse peritoneal leiomyomatosis 10.4 CD34 CALD1
27 ovarian fetiform teratoma 10.4 CEACAM5 AFP
28 neuronal intestinal dysplasia, type b 10.4 KIT CD34
29 ovarian solid teratoma 10.4 CD34 AFP
30 malignant gastric teratoma 10.4 KIT AFP
31 gastric teratoma 10.4 KIT AFP
32 pineal region teratoma 10.4 KIT AFP
33 extragonadal seminoma 10.4 KIT AFP
34 sclerosing liposarcoma 10.4 KIT CD34
35 prostate embryonal rhabdomyosarcoma 10.4 KIT CALD1
36 glomangiomyoma 10.4 CD34 CALD1
37 immature teratoma of ovary 10.4 CEACAM5 AFP
38 retroperitoneal hemangiopericytoma 10.4 KIT CD34
39 thymus adenocarcinoma 10.4 KIT CEACAM5
40 spindle cell synovial sarcoma 10.4 CD34 CALD1
41 lipoma of spermatic cord 10.4 ANO1 AFP
42 middle ear cholesterol granuloma 10.4 CEACAM5 CD34
43 rectum signet ring adenocarcinoma 10.4 CEACAM5 AFP
44 intravenous leiomyomatosis 10.4 CD34 CALD1
45 subserous uterine fibroid 10.4 CEACAM5 AFP
46 adenoid basal cell carcinoma 10.4 KIT CEACAM5
47 vulvar sarcoma 10.3 CD34 CALD1
48 intratubular embryonal carcinoma 10.3 KIT AFP
49 bilateral hypoactive labyrinth 10.3 KIT ANO1
50 paratesticular lipoma 10.3 ANO1 AFP

Graphical network of the top 20 diseases related to Liver Leiomyosarcoma:



Diseases related to Liver Leiomyosarcoma

Symptoms & Phenotypes for Liver Leiomyosarcoma

GenomeRNAi Phenotypes related to Liver Leiomyosarcoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.13 AFP ALB ANO1 CALB2 CALD1 CD163
2 no effect GR00402-S-2 10.13 ALB ANO1 CALB2 CALD1 CD34 CEACAM5
3 Strongly decreased CFP-tsO45G cell surface transport GR00360-A-1 9.65 ANO1 GPT HADHA KIT SYT1
4 Strongly decreased CFP-tsO45G cell surface transport GR00360-A-2 9.65 ANO1 GPT HADHA KIT SYT1

MGI Mouse Phenotypes related to Liver Leiomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 10.03 ALB ANO1 CALD1 CD163 CEACAM5 CHGA
2 renal/urinary system MP:0005367 9.97 ALB ANO1 CALD1 CHGA CR2 GPC3
3 homeostasis/metabolism MP:0005376 9.97 AFP ALB ANO1 CD163 CD34 CEACAM5
4 neoplasm MP:0002006 9.91 AFP ALB CD34 CEACAM5 KIT PSMB9
5 cardiovascular system MP:0005385 9.7 ALB ANO1 CD163 CEACAM5 CHGA F2
6 respiratory system MP:0005388 9.23 ANO1 CD163 F2 GPC3 KIT PSMB9

Drugs & Therapeutics for Liver Leiomyosarcoma

Search Clinical Trials, NIH Clinical Center for Liver Leiomyosarcoma

Genetic Tests for Liver Leiomyosarcoma

Anatomical Context for Liver Leiomyosarcoma

Organs/tissues related to Liver Leiomyosarcoma:

FMA: Liver
MalaCards : Liver, Smooth Muscle, Spleen

Publications for Liver Leiomyosarcoma

Articles related to Liver Leiomyosarcoma:

(show all 45)
# Title Authors PMID Year
1
Large surgically resected leiomyosarcoma of the liver: a case report. 62
32648231 2020
2
Primary leiomyosarcoma of the liver: Two new cases and a systematic review. 62
32181431 2020
3
Review of the literature laparoscopic surgery for metastatic hepatic leiomyosarcoma associated with smooth muscle tumor of uncertain malignant potential: Case report. 62
29713398 2018
4
Primary gigantic leiomyosarcoma of the liver treated with portal vein embolization and liver resection. 62
29264587 2017
5
A rare occurrence of primary hepatic leiomyosarcoma associated with epstein barr virus infection in an AIDS patient. 62
24024048 2013
6
Chemosaturation with percutaneous hepatic perfusion for unresectable isolated hepatic metastases from sarcoma. 62
22699779 2012
7
Epstein-Barr virus-associated hepatic leiomyosarcoma after renal transplantation: case report. 62
21168698 2010
8
Masquerading primary liver leiomyosarcoma as a hemorrhagic hepatoma. 62
19788930 2010
9
Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge. 62
19688980 2009
10
[A case of primary leiomyosarcoma of the liver presenting with acute bleeding]. 62
18451694 2008
11
Hemoperitoneum secondary to spontaneous rupture of metastatic gastric leiomyosarcoma of the liver: report of a case. 62
16830295 2006
12
Myxoid leiomyosarcoma of the liver. 62
16316722 2006
13
[A case of primary leiomyosarcoma of the liver]. 62
12506253 2002
14
A case of primary myxoid leiomyosarcoma of the liver. 62
12647647 2002
15
[Primary hepatic leiomyosarcoma in a patient with gastric non-Hodgkin lymphoma]. 62
12139839 2002
16
[Liver leiomyosarcoma]. 62
12553161 2002
17
Leiomyosarcoma of the liver detected by high F-18 fluorodeoxyglucose positron emission tomographic uptake. 62
11507309 2001
18
Combined right hepatic and retrohepatic caval resection with reconstruction using a polytetrafluoroethylene graft for primary leiomyosarcoma of the liver: report of case. 62
9934835 1999
19
Brief case report. Metastatic leiomyosarcoma of the liver. 62
10224687 1998
20
Primary multiple epithelioid leiomyosarcoma of the liver. 62
8975973 1996
21
Primary leiomyosarcoma of the liver MR findings. 62
8959367 1996
22
Primary liver leiomyosarcoma: CT appearance. 62
8661764 1996
23
[Primary leiomyosarcoma of the liver 37 years after successful treatment of hereditary retinoblastoma]. 62
8761149 1996
24
Primary leiomyosarcoma of the liver mimicking liver abscess. 62
7717329 1995
25
Hepatic leiomyosarcomas: CT features with pathologic correlation. 62
7601167 1995
26
[Primary leiomyosarcoma of the liver]. 62
7748710 1995
27
[Leiomyosarcoma of the liver: a case treated by transplantation]. 62
8330697 1993
28
Primary leiomyosarcoma of the liver--a case report. 62
7680513 1993
29
Leiomyosarcoma in dogs: 44 cases (1983-1988). 62
1429139 1992
30
[Oncocytic presentation of a primary epithelioid leiomyosarcoma of the liver]. 62
1599569 1992
31
Primary leiomyosarcoma of the liver. 62
1931782 1991
32
Two autopsy cases of primary leiomyosarcoma of the liver. Superiority of muscle-specific actin immunoreactivity in diagnosis. 62
1950562 1991
33
[Rare primary hepatic neoplasms. Our experience in 2 cases: a primary lymphoma and a leiomyosarcoma of the liver]. 62
2186303 1990
34
Hepatic intra-arterial adriamycin in metastatic leiomyosarcoma: exploiting the steep dose-response curve. 62
3626566 1987
35
[Clinicopathologic manifestations in 2 cases of primary leiomyosarcoma of the liver]. 62
3623529 1987
36
[A case of primary leiomyosarcoma of the liver]. 62
6392626 1984
37
Ten-year survival after synchronous resection of liver metastasis from intestinal leiomyosarcoma. 62
7226067 1981
38
Hepatic leiomyosarcoma: ultrastructural study and review of the differential diagnosis. 62
730153 1978
39
[Primary leiomyosarcoma of the liver (author's transl)]. 62
716654 1978
40
Primary leiomyosarcoma of the liver. 62
326457 1977
41
Hemangiosarcoma of liver and spleen treated by hepatic artery ligation, intraportal infusion chemotherapy, and splenectomy. 62
986237 1976
42
Primary leiomyosarcoma of the liver. 62
4809237 1974
43
Hepatic artery ligation for metastastic leiomyosarcoma of the liver. 62
4139299 1972
44
Primary leiomyosarcoma of the liver. 62
5560846 1971
45
[Leiomyosarcoma of the liver (case report)]. 62
5516761 1970

Variations for Liver Leiomyosarcoma

Expression for Liver Leiomyosarcoma

Search GEO for disease gene expression data for Liver Leiomyosarcoma.

Pathways for Liver Leiomyosarcoma

GO Terms for Liver Leiomyosarcoma

Biological processes related to Liver Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900738 9.26 F2 CHGA
2 mast cell chemotaxis GO:0002551 8.92 KIT CHGA

Sources for Liver Leiomyosarcoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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