MCID: LVR010
MIFTS: 30

Liver Leiomyosarcoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Liver Leiomyosarcoma

MalaCards integrated aliases for Liver Leiomyosarcoma:

Name: Liver Leiomyosarcoma 12 15 70
Leiomyosarcoma of the Liver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5296
NCIt 50 C5756
UMLS 70 C1333969

Summaries for Liver Leiomyosarcoma

Disease Ontology : 12 A leiomyosarcoma and sarcoma of liver that is located in the liver.

MalaCards based summary : Liver Leiomyosarcoma, also known as leiomyosarcoma of the liver, is related to rare tumor and smooth muscle tumor. An important gene associated with Liver Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Hematopoietic cell lineage and Glucocorticoid receptor regulatory network. Affiliated tissues include liver, spleen and smooth muscle, and related phenotype is renal/urinary system.

Related Diseases for Liver Leiomyosarcoma

Diseases related to Liver Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 470)
# Related Disease Score Top Affiliating Genes
1 rare tumor 30.7 KIT CR2
2 smooth muscle tumor 30.1 KIT CR2 CD34 CALD1
3 intrahepatic cholangiocarcinoma 29.8 KRT7 GPC3 AFP
4 leiomyosarcoma 29.8 WT1 PSMB9 KIT ENO2
5 teratoma 28.7 KRT7 KIT GPC3 ENO2 CHGA CALB2
6 glomangioma 10.4 CD34 CALD1
7 urethra leiomyoma 10.4 KIT CALD1
8 intravascular angioleiomyoma 10.4 CD34 CALD1
9 breast myofibroblastoma 10.4 CD34 CALD1
10 pulmonary vein leiomyosarcoma 10.4 CD34 CALD1
11 glomangiomyoma 10.4 CD34 CALD1
12 prostate embryonal rhabdomyosarcoma 10.4 KIT CALD1
13 vulvar leiomyosarcoma 10.4 CD34 CALD1
14 spinal cord sarcoma 10.4 KIT CD34
15 gastric leiomyoma 10.4 KIT CALD1
16 small intestine leiomyosarcoma 10.4 KIT CD34
17 glomangiosarcoma 10.4 CD34 CALD1
18 gastric liposarcoma 10.4 KIT CD34
19 mucocele of appendix 10.4 KIT CD34
20 mediastinum seminoma 10.4 KIT AFP
21 adult fibrosarcoma 10.4 CD34 CALD1
22 cervical polyp 10.4 CD34 CALD1
23 mixed germ cell tumor 10.4 KIT AFP
24 intravenous leiomyomatosis 10.4 CD34 CALD1
25 ovarian solid teratoma 10.4 CD34 AFP
26 extragonadal seminoma 10.4 KIT AFP
27 adult teratoma 10.4 CHGA AFP
28 cutaneous leiomyosarcoma 10.4 CD34 CALD1
29 subungual glomus tumor 10.4 CD34 CALD1
30 vulvar leiomyoma 10.4 CD34 CALD1
31 infiltrating angiolipoma 10.4 CD34 CALD1
32 angiolipoma 10.4 CD34 CALD1
33 papillary adenofibroma 10.4 CD34 AFP
34 heart sarcoma 10.4 KIT CD34
35 intravascular fasciitis 10.4 CD34 CALD1
36 bizarre leiomyoma 10.4 PSMB9 CALD1
37 extraosseous osteosarcoma 10.4 CD34 CALD1
38 mixed germ cell cancer 10.4 KIT AFP
39 malignant mesenchymoma 10.4 CD34 CALD1
40 ovarian melanoma 10.3 CALD1 CALB2
41 ovarian fibrothecoma 10.3 KIT CALB2
42 nasal cavity benign neoplasm 10.3 KIT CD34
43 prostate stromal sarcoma 10.3 KIT CD34
44 hepatic angiomyolipoma 10.3 CD34 AFP
45 ovarian embryonal carcinoma 10.3 GPC3 AFP
46 papillary thymic adenocarcinoma 10.3 CHGA CALB2
47 benign breast phyllodes tumor 10.3 KIT CD34
48 kidney hemangiopericytoma 10.3 CD34 CALB2
49 esophageal neuroendocrine tumor 10.3 KRT5 CHGA
50 dysgerminoma of ovary 10.3 KIT AFP

Graphical network of the top 20 diseases related to Liver Leiomyosarcoma:



Diseases related to Liver Leiomyosarcoma

Symptoms & Phenotypes for Liver Leiomyosarcoma

MGI Mouse Phenotypes related to Liver Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.17 CHGA CR2 GATA3 GPC3 KIT KRT7

Drugs & Therapeutics for Liver Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Liver Leiomyosarcoma

Genetic Tests for Liver Leiomyosarcoma

Anatomical Context for Liver Leiomyosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Liver Leiomyosarcoma:

19
Liver

MalaCards organs/tissues related to Liver Leiomyosarcoma:

40
Liver, Spleen, Smooth Muscle

Publications for Liver Leiomyosarcoma

Articles related to Liver Leiomyosarcoma:

(show all 45)
# Title Authors PMID Year
1
Large surgically resected leiomyosarcoma of the liver: a case report. 61
32648231 2020
2
Primary leiomyosarcoma of the liver: Two new cases and a systematic review. 61
32181431 2020
3
Review of the literature laparoscopic surgery for metastatic hepatic leiomyosarcoma associated with smooth muscle tumor of uncertain malignant potential: Case report. 61
29713398 2018
4
Primary gigantic leiomyosarcoma of the liver treated with portal vein embolization and liver resection. 61
29264587 2017
5
A rare occurrence of primary hepatic leiomyosarcoma associated with epstein barr virus infection in an AIDS patient. 61
24024048 2013
6
Chemosaturation with percutaneous hepatic perfusion for unresectable isolated hepatic metastases from sarcoma. 61
22699779 2012
7
Epstein-Barr virus-associated hepatic leiomyosarcoma after renal transplantation: case report. 61
21168698 2010
8
Masquerading primary liver leiomyosarcoma as a hemorrhagic hepatoma. 61
19788930 2010
9
Primary hepatic leiomyosarcoma in a young man after Hodgkin's disease: diagnostic pitfalls and therapeutic challenge. 61
19688980 2009
10
[A case of primary leiomyosarcoma of the liver presenting with acute bleeding]. 61
18451694 2008
11
Hemoperitoneum secondary to spontaneous rupture of metastatic gastric leiomyosarcoma of the liver: report of a case. 61
16830295 2006
12
Myxoid leiomyosarcoma of the liver. 61
16316722 2006
13
[A case of primary leiomyosarcoma of the liver]. 61
12506253 2002
14
A case of primary myxoid leiomyosarcoma of the liver. 61
12647647 2002
15
[Primary hepatic leiomyosarcoma in a patient with gastric non-Hodgkin lymphoma]. 61
12139839 2002
16
[Liver leiomyosarcoma]. 61
12553161 2002
17
Leiomyosarcoma of the liver detected by high F-18 fluorodeoxyglucose positron emission tomographic uptake. 61
11507309 2001
18
Combined right hepatic and retrohepatic caval resection with reconstruction using a polytetrafluoroethylene graft for primary leiomyosarcoma of the liver: report of case. 61
9934835 1999
19
Brief case report. Metastatic leiomyosarcoma of the liver. 61
10224687 1998
20
Primary multiple epithelioid leiomyosarcoma of the liver. 61
8975973 1996
21
Primary leiomyosarcoma of the liver MR findings. 61
8959367 1996
22
Primary liver leiomyosarcoma: CT appearance. 61
8661764 1996
23
[Primary leiomyosarcoma of the liver 37 years after successful treatment of hereditary retinoblastoma]. 61
8761149 1996
24
Primary leiomyosarcoma of the liver mimicking liver abscess. 61
7717329 1995
25
Hepatic leiomyosarcomas: CT features with pathologic correlation. 61
7601167 1995
26
[Primary leiomyosarcoma of the liver]. 61
7748710 1995
27
[Leiomyosarcoma of the liver: a case treated by transplantation]. 61
8330697 1993
28
Primary leiomyosarcoma of the liver--a case report. 61
7680513 1993
29
Leiomyosarcoma in dogs: 44 cases (1983-1988). 61
1429139 1992
30
[Oncocytic presentation of a primary epithelioid leiomyosarcoma of the liver]. 61
1599569 1992
31
Two autopsy cases of primary leiomyosarcoma of the liver. Superiority of muscle-specific actin immunoreactivity in diagnosis. 61
1950562 1991
32
Primary leiomyosarcoma of the liver. 61
1931782 1991
33
[Rare primary hepatic neoplasms. Our experience in 2 cases: a primary lymphoma and a leiomyosarcoma of the liver]. 61
2186303 1990
34
Hepatic intra-arterial adriamycin in metastatic leiomyosarcoma: exploiting the steep dose-response curve. 61
3626566 1987
35
[Clinicopathologic manifestations in 2 cases of primary leiomyosarcoma of the liver]. 61
3623529 1987
36
[A case of primary leiomyosarcoma of the liver]. 61
6392626 1984
37
Ten-year survival after synchronous resection of liver metastasis from intestinal leiomyosarcoma. 61
7226067 1981
38
Hepatic leiomyosarcoma: ultrastructural study and review of the differential diagnosis. 61
730153 1978
39
[Primary leiomyosarcoma of the liver (author's transl)]. 61
716654 1978
40
Primary leiomyosarcoma of the liver. 61
326457 1977
41
Hemangiosarcoma of liver and spleen treated by hepatic artery ligation, intraportal infusion chemotherapy, and splenectomy. 61
986237 1976
42
Primary leiomyosarcoma of the liver. 61
4809237 1974
43
Hepatic artery ligation for metastastic leiomyosarcoma of the liver. 61
4139299 1972
44
Primary leiomyosarcoma of the liver. 61
5560846 1971
45
[Leiomyosarcoma of the liver (case report)]. 61
5516761 1970

Variations for Liver Leiomyosarcoma

Expression for Liver Leiomyosarcoma

Search GEO for disease gene expression data for Liver Leiomyosarcoma.

Pathways for Liver Leiomyosarcoma

Pathways related to Liver Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 KIT CR2 CD34
2 11.25 KRT5 GATA3 AFP
3 11.03 KIT GATA3 CD34
4 10.69 KIT GATA3 CD34

GO Terms for Liver Leiomyosarcoma

Biological processes related to Liver Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.5 WT1 KIT GATA3
2 embryonic hemopoiesis GO:0035162 9.4 KIT GATA3
3 mast cell degranulation GO:0043303 9.37 KIT CHGA
4 mesenchymal to epithelial transition GO:0060231 9.26 WT1 GATA3
5 mast cell chemotaxis GO:0002551 9.16 KIT CHGA
6 mast cell differentiation GO:0060374 8.96 KIT GATA3
7 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Sources for Liver Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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