MCID: LVR006
MIFTS: 28

Liver Lymphoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Immune diseases, Liver diseases

Aliases & Classifications for Liver Lymphoma

MalaCards integrated aliases for Liver Lymphoma:

Name: Liver Lymphoma 12 15 71
Lymphoma of Liver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:901
NCIt 49 C4949
UMLS 71 C1112746

Summaries for Liver Lymphoma

MalaCards based summary : Liver Lymphoma, also known as lymphoma of liver, is related to cholangiocarcinoma and b-cell lymphoma. An important gene associated with Liver Lymphoma is CD79A (CD79a Molecule), and among its related pathways/superpathways are NF-kappaB Signaling and MECP2 and Associated Rett Syndrome. The drugs rituximab and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and t cells.

Related Diseases for Liver Lymphoma

Diseases related to Liver Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 cholangiocarcinoma 29.1 MME CEACAM5 AFP
2 b-cell lymphoma 28.9 MME CD5 BCL6
3 peripheral t-cell lymphoma 28.8 MME CD5 BCL6
4 follicular lymphoma 28.8 MME CD5 BCL6
5 diffuse large b-cell lymphoma 28.5 MME CD79A CD5 BCL6
6 lymphoma, non-hodgkin, familial 28.0 MME MIR103A1 CD79A CD5 BCL6
7 hilar lung carcinoma 10.3 MME CD79A
8 lung hilum cancer 10.3 MME CD79A
9 infected hydrocele 10.3 CD79A AFP
10 epididymal neoplasm 10.3 MME AFP
11 ovarian wilms' cancer 10.3 MME AFP
12 small intestine lymphoma 10.3 CD79A BCL6
13 cystadenofibroma 10.3 MME AFP
14 ureteral lymphoma 10.2 MME BCL6
15 epididymis adenocarcinoma 10.2 MME AFP
16 epididymis cancer 10.2 MME AFP
17 heart lymphoma 10.2 MME BCL6
18 paranasal sinus lymphoma 10.2 CD79A BCL6
19 ovarian lymphoma 10.2 MME BCL6
20 t-cell/histiocyte rich large b cell lymphoma 10.2 MME BCL6
21 lymphoma 10.2
22 liver lipoma 10.1 CEACAM5 AFP
23 malignant sertoli-leydig cell tumor 10.1 CEACAM5 AFP
24 urachal adenocarcinoma 10.1 CEACAM5 AFP
25 gestational ovarian choriocarcinoma 10.1 CEACAM5 AFP
26 immature teratoma of ovary 10.1 CEACAM5 AFP
27 mature teratoma 10.1 CEACAM5 AFP
28 rectum signet ring adenocarcinoma 10.1 CEACAM5 AFP
29 ovarian mixed germ cell neoplasm 10.1 CEACAM5 AFP
30 renal pelvis adenocarcinoma 10.1 CEACAM5 AFP
31 bile duct cystadenocarcinoma 10.1 CEACAM5 AFP
32 colonic lymphangioma 10.1 CEACAM5 AFP
33 adult teratoma 10.1 CEACAM5 AFP
34 orofaciodigital syndrome viii 10.1 BCL6 AFP
35 cervical serous adenocarcinoma 10.1 MME CEACAM5
36 multicentric castleman disease 10.1 CD79A BCL6
37 female urethral cancer 10.1 MME CEACAM5
38 liver sarcoma 10.1 CEACAM5 AFP
39 eccrine papillary adenocarcinoma 10.1 MME CEACAM5
40 benign mesothelioma 10.1 CEACAM5 AFP
41 clear cell hidradenoma 10.1 MME CEACAM5
42 hidradenoma 10.1 MME CEACAM5
43 sarcomatous intrahepatic cholangiocarcinoma 10.1 CEACAM5 AFP
44 urethral benign neoplasm 10.0 MME CEACAM5
45 eccrine sweat gland neoplasm 10.0 MME CEACAM5
46 pancreas lymphoma 10.0 CEACAM5 BCL6
47 sweat gland neoplasm 10.0 MME CEACAM5
48 pancreatic mucinous cystadenoma 10.0 MME CEACAM5
49 bile duct cysts 10.0 CEACAM5 AFP
50 nasal cavity olfactory neuroblastoma 10.0 MME CEACAM5

Graphical network of the top 20 diseases related to Liver Lymphoma:



Diseases related to Liver Lymphoma

Symptoms & Phenotypes for Liver Lymphoma

Drugs & Therapeutics for Liver Lymphoma

Drugs for Liver Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 2 174722-31-7 10201696
2
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
3
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
4 Anti-Infective Agents Phase 2
5 Immunologic Factors Phase 2
6 Antibodies, Monoclonal Phase 2
7 Antineoplastic Agents, Immunological Phase 2
8 Bendamustine Hydrochloride Phase 2
9 Alkylating Agents Phase 2
10 Antimetabolites Phase 2
11 Immunosuppressive Agents Phase 2
12 Antirheumatic Agents Phase 2
13 Antibodies Phase 2
14 Immunoglobulins Phase 2
15 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized 3-Arm Phase II Study Comparing 1.) Bendamustine, Rituximab and High Dose Cytarabine (BR/CR) 2.) Bendamustine, Rituximab, High Dose Cytarabine and Acalabrutinib (BR/CR-A), and 3.) Bendamustine, Rituximab and Acalabrutinib (BR-A) in Patients </= 70 Years Old With Untreated Mantle Cell Lymphoma Recruiting NCT04115631 Phase 2 Acalabrutinib;Bendamustine;Bendamustine Hydrochloride;Cytarabine

Search NIH Clinical Center for Liver Lymphoma

Genetic Tests for Liver Lymphoma

Anatomical Context for Liver Lymphoma

MalaCards organs/tissues related to Liver Lymphoma:

40
Liver, Lung, T Cells, B Cells

Publications for Liver Lymphoma

Articles related to Liver Lymphoma:

(show all 47)
# Title Authors PMID Year
1
Primary Hodgkin's lymphoma of liver in HIV-a case report and review of literature. 61
30264017 2018
2
Pregnant Lady With Undiagnosed Hodgkin's Disease Presenting As Secondary Sclerosing Cholangitis. 61
29331005 2017
3
Successful hemihepatectomy following chemotherapy for primary liver lymphoma: case report and review of literature. 61
29154242 2017
4
Prediagnosis Body Mass Index and Risk of Secondary Primary Cancer in Male Cancer Survivors: A Large Cohort Study. 61
27863195 2016
5
Primary extrahepatic bile duct lymphoma mimicking Klatskin's tumor, dramatic response to chemotherapy. 61
25681815 2015
6
Primary T-cell lymphoma of liver. 61
23608840 2013
7
Primary liver lymphoma. 61
23847828 2013
8
Liver lymphoma. 61
22341908 2012
9
[Hepatic granulomas]. 61
20832918 2011
10
Primary non-Hodgkin lymphoma of liver. 61
19672429 2009
11
Primary liver lymphoma with hypercalcemia: a case report. 61
19419919 2009
12
[Malignant histiocytosis-like B-cell lymphoma of liver: report of a case]. 61
18509992 2008
13
ACTuDB, a new database for the integrated analysis of array-CGH and clinical data for tumors. 61
17496932 2007
14
[Primary liver lymphoma in a patient with hepatitis C]. 61
17540154 2007
15
[Primary non-Hodgkin lymphoma of the liver: case report and review of the literature]. 61
17137818 2006
16
Primary liver AIDS-related lympoma. 61
17119682 2006
17
Primary liver lymphoma in a patient with chronic hepatitis C. 61
16520842 2006
18
Primary lymphoma of the liver: clinical features and outcome of 9 patients. 61
17357208 2005
19
Anticarcinogenic effects of glycoalkaloids from potatoes against human cervical, liver, lymphoma, and stomach cancer cells. 61
16029012 2005
20
Mri findings in primary non-Hodgkin's lymphoma of the liver. 61
15792163 2005
21
Primary lymphoma of liver: a case report and review of literature. 61
15727083 2004
22
[Primary non-Hodgkin lymphoma of the liver in HIV infected patient: case-report]. 61
15276292 2004
23
[Primary liver lymphoma. Diagnostic and therapeutic implications]. 61
11412599 2001
24
Imaging of primary non-Hodgkin's lymphoma of the liver. 61
11286581 2001
25
Non-hodgkin's lymphoma of the liver in patients with AIDS: sonographic, CT, and MRI findings. 61
11329154 2001
26
Sequential use of gadolinium chelate and mangafodipir trisodium for the assessment of focal liver lesions: initial observations. 61
11121698 2000
27
[31P-MR spectroscopy of the human liver--the spectral indications of lymphoma infiltration]. 61
9289045 1997
28
Synchronous primary hepatic lymphoma and epidermoid lung carcinoma treated with chemotherapy and surgery. 61
7747705 1995
29
The incidence of vertebral body metastases. 61
8567140 1995
30
[Malignant lymphoma of liver]. 61
8749481 1995
31
US, CT, and MRI of primary and secondary liver lymphoma. 61
8188908 1994
32
Primary hepatic lymphoma mimicking fulminant hepatic failure. 61
8270296 1993
33
Budd-Chiari syndrome: analysis of 30 cases. 61
8328682 1993
34
Malignant lymphoma imitating hepatitis. 61
8453587 1993
35
Primary liver lymphoma associated with primary biliary cirrhosis. 61
8454265 1993
36
Primary liver lymphoma: a diagnostic dilemma. 61
1853833 1991
37
[Ultrasonographic findings in hepatoblastoma]. 61
1657030 1991
38
Primary Liver Lymphoma: A Case Report with Review of Literature. 61
27458676 1991
39
Primary non-Hodgkin's lymphoma of liver with humoral hypercalcaemia. 61
1699217 1990
40
Liver lymphoma in systemic lupus erythematosus. 61
2696791 1989
41
Clinical correlates in patients with elevated platelet-associated immunoglobulins. 61
3355094 1988
42
Detection of spread of malignant lymphoma to the liver by low field strength magnetic resonance imaging. 61
3094803 1986
43
Primary lymphoma of the liver. Ten cases and a review of the literature. 61
3840404 1985
44
Cesium therapy in cancer patients. 61
6522427 1984
45
Drinking water and cancer in Louisiana. A retrospective mortality study. 61
7137152 1982
46
Angiography of the liver in lymphoma. 61
556355 1977
47
Primary lymphocytic follicular lymphoma of liver. 61
4888143 1969

Variations for Liver Lymphoma

Expression for Liver Lymphoma

Search GEO for disease gene expression data for Liver Lymphoma.

Pathways for Liver Lymphoma

Pathways related to Liver Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.85 CEACAM5 CD79A BCL6
2 11.05 FGF4 BCL6
3 10.99 MME CEACAM5 CD79A CD5
4 10.86 MME CD5 BCL6

GO Terms for Liver Lymphoma

Biological processes related to Liver Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell activation GO:0042113 8.62 CD79A AKAP17A

Sources for Liver Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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