MCID: LVR006
MIFTS: 25

Liver Lymphoma

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Immune diseases, Liver diseases

Aliases & Classifications for Liver Lymphoma

MalaCards integrated aliases for Liver Lymphoma:

Name: Liver Lymphoma 12 15 70
Lymphoma of Liver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:901
NCIt 50 C4949
UMLS 70 C1112746

Summaries for Liver Lymphoma

MalaCards based summary : Liver Lymphoma, also known as lymphoma of liver, is related to infected hydrocele and mediastinal cancer. An important gene associated with Liver Lymphoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cytarabine and rituximab have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotype is Increased shRNA abundance.

Related Diseases for Liver Lymphoma

Diseases related to Liver Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 infected hydrocele 10.2 CD79A AFP
2 mediastinal cancer 10.2 CD79A AFP
3 germ cell and embryonal cancer 10.0 FGF4 AFP
4 epididymal neoplasm 10.0 MME AFP
5 hilar lung carcinoma 9.9 MME CD79A
6 lung hilum cancer 9.9 MME CD79A
7 ovarian mixed germ cell neoplasm 9.9 MME AFP
8 paranasal sinus lymphoma 9.9 MME CD79A
9 bladder lymphoma 9.9 MME CD79A
10 epiglottis neoplasm 9.9 MME CD79A
11 lung lymphoma 9.9 MME CD79A
12 bone lymphoma 9.9 MME CD79A
13 colon lymphoma 9.9 MME CD79A
14 epididymis adenocarcinoma 9.9 MME AFP
15 breast lymphoma 9.9 MME CD79A
16 epididymis cancer 9.9 MME AFP
17 gray zone lymphoma 9.9 MME CD79A
18 cerebral lymphoma 9.9 MME CD79A
19 gastrointestinal lymphoma 9.9 MME CD79A
20 pediatric lymphoma 9.9 MME CD79A
21 breast osteosarcoma 9.9 MME CD79A
22 intrahepatic bile duct adenoma 9.9 MME AFP
23 composite lymphoma 9.9 MME CD79A
24 testicular lymphoma 9.9 MME CD79A
25 gallbladder lymphoma 9.9 MME CD79A
26 spleen cancer 9.9 MME CD79A
27 cll/sll 9.9 MME CD79A
28 mixed cell type cancer 9.9 MME AFP
29 central nervous system hematologic cancer 9.9 MME CD79A
30 plasma protein metabolism disease 9.9 MME AFP
31 lymphoplasmacytic lymphoma 9.9 MME CD79A
32 tubular adenocarcinoma 9.9 MME AFP
33 diffuse large b-cell lymphoma 9.9
34 lymphoma 9.9
35 b-cell lymphoma 9.9
36 reproductive organ benign neoplasm 9.8 MME AFP
37 cystadenoma 9.8 MME AFP
38 marginal zone b-cell lymphoma 9.8 MME CD79A
39 mature t-cell and nk-cell lymphoma 9.8 MME CD79A
40 peripheral t-cell lymphoma 9.8
41 follicular lymphoma 9.8
42 constipation 9.8
43 fibrosarcoma of bone 9.8
44 histiocytosis 9.8
45 splenomegaly 9.8
46 hepatosplenic t-cell lymphoma 9.8
47 sclerosing hepatic carcinoma 9.8 MME CD79A AFP
48 membranous nephropathy 9.7 MME CD79A
49 mature b-cell neoplasm 9.7 MME CD79A
50 systemic lupus erythematosus 9.7

Graphical network of the top 20 diseases related to Liver Lymphoma:



Diseases related to Liver Lymphoma

Symptoms & Phenotypes for Liver Lymphoma

GenomeRNAi Phenotypes related to Liver Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 AFP CD79A ORC4

Drugs & Therapeutics for Liver Lymphoma

Drugs for Liver Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
2
rituximab Approved Phase 2 174722-31-7 10201696
3
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
4 Antineoplastic Agents, Immunological Phase 2
5 Immunosuppressive Agents Phase 2
6 Antirheumatic Agents Phase 2
7 Antibodies Phase 2
8 Immunoglobulins, Intravenous Phase 2
9 Immunologic Factors Phase 2
10 Immunoglobulins Phase 2
11 Alkylating Agents Phase 2
12 Antiviral Agents Phase 2
13 Antibodies, Monoclonal Phase 2
14 Antimetabolites Phase 2
15 Anti-Infective Agents Phase 2
16 Bendamustine Hydrochloride Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized 3-Arm Phase II Study Comparing 1.) Bendamustine, Rituximab and High Dose Cytarabine (BR/CR) 2.) Bendamustine, Rituximab, High Dose Cytarabine and Acalabrutinib (BR/CR-A), and 3.) Bendamustine, Rituximab and Acalabrutinib (BR-A) in Patients </= 70 Years Old With Untreated Mantle Cell Lymphoma Recruiting NCT04115631 Phase 2 Acalabrutinib;Bendamustine;Bendamustine Hydrochloride;Cytarabine

Search NIH Clinical Center for Liver Lymphoma

Genetic Tests for Liver Lymphoma

Anatomical Context for Liver Lymphoma

MalaCards organs/tissues related to Liver Lymphoma:

40
Liver

Publications for Liver Lymphoma

Articles related to Liver Lymphoma:

(show all 50)
# Title Authors PMID Year
1
Practice and prospects for PET/CT guided interventions. 61
33494585 2021
2
Primary Liver Lymphoma Presenting as Liver Nodules. 61
33791400 2021
3
Primary Lymphoma of Liver-a Rare Space-Occupying Lesion. 61
32333249 2020
4
Primary Hodgkin's lymphoma of liver in HIV-a case report and review of literature. 61
30264017 2018
5
Pregnant Lady With Undiagnosed Hodgkin's Disease Presenting As Secondary Sclerosing Cholangitis. 61
29331005 2017
6
Successful hemihepatectomy following chemotherapy for primary liver lymphoma: case report and review of literature. 61
29154242 2017
7
Prediagnosis Body Mass Index and Risk of Secondary Primary Cancer in Male Cancer Survivors: A Large Cohort Study. 61
27863195 2016
8
Primary extrahepatic bile duct lymphoma mimicking Klatskin's tumor, dramatic response to chemotherapy. 61
25681815 2015
9
Primary T-cell lymphoma of liver. 61
23608840 2013
10
Primary liver lymphoma. 61
23847828 2013
11
Liver lymphoma. 61
22341908 2012
12
[Hepatic granulomas]. 61
20832918 2011
13
Primary non-Hodgkin lymphoma of liver. 61
19672429 2009
14
Primary liver lymphoma with hypercalcemia: a case report. 61
19419919 2009
15
[Malignant histiocytosis-like B-cell lymphoma of liver: report of a case]. 61
18509992 2008
16
ACTuDB, a new database for the integrated analysis of array-CGH and clinical data for tumors. 61
17496932 2007
17
[Primary liver lymphoma in a patient with hepatitis C]. 61
17540154 2007
18
[Primary non-Hodgkin lymphoma of the liver: case report and review of the literature]. 61
17137818 2006
19
Primary liver AIDS-related lympoma. 61
17119682 2006
20
Primary liver lymphoma in a patient with chronic hepatitis C. 61
16520842 2006
21
Primary lymphoma of the liver: clinical features and outcome of 9 patients. 61
17357208 2005
22
Anticarcinogenic effects of glycoalkaloids from potatoes against human cervical, liver, lymphoma, and stomach cancer cells. 61
16029012 2005
23
Mri findings in primary non-Hodgkin's lymphoma of the liver. 61
15792163 2005
24
Primary lymphoma of liver: a case report and review of literature. 61
15727083 2004
25
[Primary non-Hodgkin lymphoma of the liver in HIV infected patient: case-report]. 61
15276292 2004
26
[Primary liver lymphoma. Diagnostic and therapeutic implications]. 61
11412599 2001
27
Imaging of primary non-Hodgkin's lymphoma of the liver. 61
11286581 2001
28
Non-hodgkin's lymphoma of the liver in patients with AIDS: sonographic, CT, and MRI findings. 61
11329154 2001
29
Sequential use of gadolinium chelate and mangafodipir trisodium for the assessment of focal liver lesions: initial observations. 61
11121698 2000
30
[31P-MR spectroscopy of the human liver--the spectral indications of lymphoma infiltration]. 61
9289045 1997
31
Synchronous primary hepatic lymphoma and epidermoid lung carcinoma treated with chemotherapy and surgery. 61
7747705 1995
32
The incidence of vertebral body metastases. 61
8567140 1995
33
[Malignant lymphoma of liver]. 61
8749481 1995
34
US, CT, and MRI of primary and secondary liver lymphoma. 61
8188908 1994
35
Primary hepatic lymphoma mimicking fulminant hepatic failure. 61
8270296 1993
36
Budd-Chiari syndrome: analysis of 30 cases. 61
8328682 1993
37
Malignant lymphoma imitating hepatitis. 61
8453587 1993
38
Primary liver lymphoma associated with primary biliary cirrhosis. 61
8454265 1993
39
Primary liver lymphoma: a diagnostic dilemma. 61
1853833 1991
40
[Ultrasonographic findings in hepatoblastoma]. 61
1657030 1991
41
Primary Liver Lymphoma: A Case Report with Review of Literature. 61
27458676 1991
42
Primary non-Hodgkin's lymphoma of liver with humoral hypercalcaemia. 61
1699217 1990
43
Liver lymphoma in systemic lupus erythematosus. 61
2696791 1989
44
Clinical correlates in patients with elevated platelet-associated immunoglobulins. 61
3355094 1988
45
Detection of spread of malignant lymphoma to the liver by low field strength magnetic resonance imaging. 61
3094803 1986
46
Primary lymphoma of the liver. Ten cases and a review of the literature. 61
3840404 1985
47
Cesium therapy in cancer patients. 61
6522427 1984
48
Drinking water and cancer in Louisiana. A retrospective mortality study. 61
7137152 1982
49
Angiography of the liver in lymphoma. 61
556355 1977
50
Primary lymphocytic follicular lymphoma of liver. 61
4888143 1969

Variations for Liver Lymphoma

Expression for Liver Lymphoma

Search GEO for disease gene expression data for Liver Lymphoma.

Pathways for Liver Lymphoma

Pathways related to Liver Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.6 FGF4 CD79A

GO Terms for Liver Lymphoma

Sources for Liver Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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