MCID: LVR014
MIFTS: 30

Liver Sarcoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Liver Sarcoma

MalaCards integrated aliases for Liver Sarcoma:

Name: Liver Sarcoma 12 15
Sarcoma of Liver 73
Hepatic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:270
NCIt 50 C4437
SNOMED-CT 68 254601002
UMLS 73 C0345906

Summaries for Liver Sarcoma

Disease Ontology : 12 A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located in the liver.

MalaCards based summary : Liver Sarcoma, also known as sarcoma of liver, is related to sternum cancer and scrotal carcinoma. An important gene associated with Liver Sarcoma is AFP (Alpha Fetoprotein). Affiliated tissues include the liver and liver, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Liver Sarcoma

Diseases related to Liver Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 sternum cancer 10.8 AFP CD68
2 scrotal carcinoma 10.7 AFP CD68
3 mixed liposarcoma 10.6 CD68 PDGFB
4 liver rhabdomyosarcoma 10.6 CA4 PDGFB
5 fox-fordyce disease 10.5 CD68 CEACAM5
6 adult teratoma 10.5 AFP CHGA
7 mucinous cystadenofibroma 10.5 AFP CEACAM5
8 urachal adenocarcinoma 10.5 AFP CEACAM5
9 liver lymphoma 10.5 AFP CEACAM5
10 lymphohistiocytoid mesothelioma 10.5 CD68 CEACAM5
11 chorioangioma 10.5 AFP PTHLH
12 melanotic medulloblastoma 10.5 AFP CEACAM5
13 skin sarcoma 10.5 CD68 PDGFB
14 pancreatic acinar cell adenocarcinoma 10.5 AFP CHGA
15 hematocele of tunica vaginalis testis 10.5 AFP CEACAM5
16 miliaria 10.5 CD68 CEACAM5
17 bile duct cystadenocarcinoma 10.5 AFP CEACAM5
18 testicular granulosa cell tumor 10.5 AFP CEACAM5
19 juvenile type testicular granulosa cell tumor 10.5 AFP CEACAM5
20 rete testis adenocarcinoma 10.4 AFP CEACAM5
21 chondroid lipoma 10.4 CD68 CEACAM5
22 papillary ependymoma 10.4 CD68 CHGA
23 pancreatoblastoma 10.4 AFP CHGA
24 malignant biphasic mesothelioma 10.4 AFP CEACAM5
25 central nervous system sarcoma 10.4 CD68 LYZ
26 rete testis neoplasm 10.4 AFP CEACAM5
27 dysgerminoma of ovary 10.4 AFP PTHLH
28 malignant giant cell tumor of soft parts 10.4 CD68 LYZ
29 clear cell acanthoma 10.4 CD68 CEACAM5
30 melanotic neurilemmoma 10.4 CD68 LYZ
31 adult xanthogranuloma 10.4 CD68 LYZ
32 extragonadal seminoma 10.4 AFP CEACAM5
33 epidermolysis bullosa, junctional, herlitz type 10.4 AFP CEACAM5
34 endodermal sinus tumor 10.4 AFP CHGA
35 leydig cell tumor 10.3 AFP PTHLH
36 clear cell adenoma 10.3 CEACAM5 PTHLH
37 aleukemic leukemia cutis 10.3 CD68 LYZ
38 female urethral cancer 10.3 CEACAM5 CHGA
39 reticulohistiocytic granuloma 10.3 CD68 LYZ
40 ulcerative stomatitis 10.3 CD68 LYZ
41 dermis tumor 10.2 LYZ PDGFB
42 xanthogranulomatous pyelonephritis 10.2 CD68 LYZ
43 tubular adenocarcinoma 10.2 AFP CHGA
44 hemangioma of intra-abdominal structure 10.2 AFP CD68 PTHLH
45 atypical follicular adenoma 10.2 CEACAM5 CHGA
46 acinar cell carcinoma 10.2 AFP CHGA
47 pancreatic serous cystadenoma 10.2 CEACAM5 CHGA
48 acute thyroiditis 10.2 CEACAM5 CHGA
49 bile duct adenocarcinoma 10.2 AFP CEACAM5
50 gastric small cell carcinoma 10.2 CEACAM5 CHGA

Graphical network of the top 20 diseases related to Liver Sarcoma:



Diseases related to Liver Sarcoma

Symptoms & Phenotypes for Liver Sarcoma

MGI Mouse Phenotypes related to Liver Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 PTHLH ADAM17 AFP CHGA EEF1A2 LYZ
2 growth/size/body region MP:0005378 9.7 PDGFB PTHLH ADAM17 CA4 CHGA EEF1A2
3 mortality/aging MP:0010768 9.56 PTHLH ADAM17 AFP CA4 CHGA EEF1A2
4 reproductive system MP:0005389 9.17 PTHLH ADAM17 AFP CA4 CHGA LYZ

Drugs & Therapeutics for Liver Sarcoma

Search Clinical Trials , NIH Clinical Center for Liver Sarcoma

Genetic Tests for Liver Sarcoma

Anatomical Context for Liver Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Liver Sarcoma:

19
The Liver

MalaCards organs/tissues related to Liver Sarcoma:

41
Liver

Publications for Liver Sarcoma

Articles related to Liver Sarcoma:

(show all 17)
# Title Authors Year
1
Surgical Treatment and Chemotherapy of Adult Primary Liver Sarcoma: Experiences from a Single Hospital in China. ( 29346784 )
2018
2
Preoperative Interventional Therapy for Childhood Undifferentiated Embryonal Liver Sarcoma: Two Retrospective Cases from a Single Center. ( 26788456 )
2015
3
Undifferentiated embryonal liver sarcoma in childhood: A case report. ( 25120671 )
2014
4
Cardiac metastases and tumor embolization: A rare sequelae of primary undifferentiated liver sarcoma. ( 25460438 )
2014
5
A single-institution retrospective cases series of childhood undifferentiated embryonal liver sarcoma (UELS): success of combined therapy and the use of orthotopic liver transplant. ( 23138115 )
2013
6
A case of undifferentiated embryonic liver sarcoma mimicking cystic hydatid disease in an endemic region of the world. ( 22075370 )
2011
7
Undifferentiated (embryonal) liver sarcoma: synchronous and metachronous occurrence with neoplasms other than mesenchymal liver hamartoma. ( 21414822 )
2011
8
[A case of undifferentiated (embryonal) liver sarcoma mimicking klatskin tumor in an adult]. ( 20168062 )
2010
9
Radiofrequency ablation as a palliative treatment of primary liver sarcoma in an inoperable patient with hepatitis C virus-related cirrhosis. ( 19745597 )
2009
10
Clinical features and spiral computed tomography analysis of undifferentiated embryonic liver sarcoma in adults. ( 19906110 )
2009
11
Primary liver sarcoma in an immunocompetent patient with hepatitis C virus infection. ( 18391609 )
2008
12
Childhood undifferentiated embryonal liver sarcoma: clinical features and immunohistochemistry analysis. ( 18926232 )
2008
13
Undifferentiated liver sarcoma -- rare entity: a case report and review of the literature. ( 18218141 )
2008
14
Clinical outcomes of surgical resections for primary liver sarcoma in adults: results from a single centre. ( 15063896 )
2004
15
Undifferentiated (embryonal) liver sarcoma of childhood: evidence of leiomyoblastic differentiation. ( 6687281 )
1983
16
Thorotrast: primary liver sarcoma 22 years after the administration. ( 5469856 )
1970
17
Enlargement of Liver-? Sarcoma. ( 19988104 )
1931

Variations for Liver Sarcoma

Expression for Liver Sarcoma

Search GEO for disease gene expression data for Liver Sarcoma.

Pathways for Liver Sarcoma

GO Terms for Liver Sarcoma

Cellular components related to Liver Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 AFP CEACAM5 CHGA LYZ PDGFB PTHLH
2 transport vesicle membrane GO:0030658 9.16 CA4 CHGA
3 basolateral plasma membrane GO:0016323 8.8 CA4 CEACAM5 PDGFB

Biological processes related to Liver Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antimicrobial humoral response GO:0019730 9.26 CHGA LYZ
2 positive regulation of blood vessel endothelial cell migration GO:0043536 9.16 ADAM17 PDGFB
3 killing of cells of other organism GO:0031640 8.96 CHGA LYZ
4 defense response to Gram-positive bacterium GO:0050830 8.8 ADAM17 CHGA LYZ

Sources for Liver Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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