Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
Release Notes Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
LCPS
MCID: LMN005
MIFTS: 24

Lmna-Related Cardiocutaneous Progeria Syndrome (LCPS)

Categories: Cardiovascular diseases, Rare diseases, Skin diseases
Data Licensing
For inquiries, contact:
[email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes
Sources

Aliases & Classifications for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section

MalaCards integrated aliases for Lmna-Related Cardiocutaneous Progeria Syndrome:

Name: Lmna-Related Cardiocutaneous Progeria Syndrome 58
Lcps 58

Characteristics:


Inheritance:

Autosomal dominant 58

Prevelance:

<1/1000000 (Worldwide) 58

Age Of Onset:

Childhood 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare skin diseases


Sources

Summaries for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section

Orphanet: 58 LMNA-related cardiocutaneous progeria syndrome is a rare, genetic, premature aging syndrome characterized by adulthood-onset cutaneous manifestations that result in a prematurely aged appearance (i.e. premature thinning and graying of scalp hair, loss of subcutaneous fat, tightening of skin) associated with prominent cardiovascular manifestations, such as accelerated atherosclerosis, calcific valve disease, and cardiomyopathy. Patients present loss of eyebrows and eyelashes in childhood and have a predisposition to develop malignancies.

MalaCards based summary: Lmna-Related Cardiocutaneous Progeria Syndrome, also known as lcps, is related to legg-calve-perthes disease. An important gene associated with Lmna-Related Cardiocutaneous Progeria Syndrome is LMNA (Lamin A/C). Affiliated tissues include skin, heart and lung, and related phenotypes are hypertension and lipoatrophy
Sources

Related Diseases for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section

Diseases related to Lmna-Related Cardiocutaneous Progeria Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 legg-calve-perthes disease 10.0

Sources

Symptoms & Phenotypes for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section

Human phenotypes related to Lmna-Related Cardiocutaneous Progeria Syndrome:

58 30 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0000822
2 lipoatrophy 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0100578
3 hypertriglyceridemia 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0002155
4 congestive heart failure 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0001635
5 mitral regurgitation 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0001653
6 emphysema 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0002097
7 mitral valve calcification 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0004382
8 premature graying of hair 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0002216
9 hypercholesterolemia 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0003124
10 intracranial hemorrhage 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0002170
11 abnormality of the pulmonary artery 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0004414
12 absent eyelashes 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0000561
13 sparse hair 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0008070
14 squamous cell carcinoma of the skin 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0006739
15 basal cell carcinoma 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0002671
16 aortic valve stenosis 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0001650
17 aortic root aneurysm 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0002616
18 absent eyebrow 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0002223
19 alopecia universalis 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0002289
20 scleroderma 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0100324
21 premature skin wrinkling 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0100678
22 pulmonary carcinoid tumor 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0030445
23 ventricular hypertrophy 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0001714
24 papillary renal cell carcinoma 58 30 Hallmark (90%) Very frequent (99-80%)
 HP:0006766
25 coronary artery atherosclerosis 30 Hallmark (90%) HP:0001677
26 abnormal intrahepatic bile duct morphology 30 Hallmark (90%) HP:0011040
27 aortic atherosclerotic lesion 30 Hallmark (90%) HP:0012397
28 coronary atherosclerosis 58 Very frequent (99-80%)
29 abnormality of the intrahepatic bile duct 58 Very frequent (99-80%)
30 aortic atherosclerosis 58 Very frequent (99-80%)
Sources

Drugs & Therapeutics for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section

Search Clinical Trials, NIH Clinical Center for Lmna-Related Cardiocutaneous Progeria Syndrome

Sources

Genetic Tests for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section
Sources

Anatomical Context for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section

Organs/tissues related to Lmna-Related Cardiocutaneous Progeria Syndrome:

MalaCards : Skin, Heart, Lung, Bone, Breast, Brain, Retina
Sources

Publications for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section

Articles related to Lmna-Related Cardiocutaneous Progeria Syndrome:

(show top 50) (show all 324)
# Title Authors PMID Year
1
Liquid Crystalline Polymers: Opportunities to Shape Neural Interfaces. 62
33501705 2022
2
Structural determination of the cell wall polysaccharide LCPS-1 in Lacticaseibacillus paracasei strain Shirota YIT 9029. 62
36103733 2022
3
Photo-Programmed Deformations in Rigid Liquid Crystalline Polymers Triggered by Body Temperature. 62
36169084 2022
4
Nucleotide-based Lanthanide Coordination Polymer Nano-Probe for Turn-on Fluorescence Sensing of Zn2+ in Serum. 62
36264098 2022
5
Efficacy of hook-type locking plate and partially threaded cancellous lag screw in the treatment of displaced medial malleolar fractures in elderly patients. 62
34089372 2022
6
Managing Hospital Capacity: Achievements and Lessons from the COVID-19 Pandemic. 62
35950299 2022
7
Liquid-Crystalline Polymers: Molecular Engineering, Hierarchical Structures, and Applications. 62
36103648 2022
8
Functional outcomes of dogs undergoing shoulder arthrodesis with 2 locking compression plates. 62
36156275 2022
9
Release of Particulate Lead from Four Lead Corrosion Products in Drinking Water: A Laboratory Study Coupled with Microscopic Observations and Computational Fluid Dynamics. 62
35989562 2022
10
Metallosis after using distal fibular locking plate for lateral malleolar fractures: a retrospective study. 62
33646355 2022
11
Numerical simulation and biomechanical analysis of locking screw caps on clavicle locking plates. 62
35905263 2022
12
Amphiphilic Liquid Crystalline Polymer Micelles That Exhibit a Phase Transition at Body Temperature. 62
35767380 2022
13
The isolation, structural features and biological activities of polysaccharide from Ligusticum chuanxiong: A review. 62
35287839 2022
14
Oridonin-loaded lipid-coated calcium phosphate nanoparticles: preparation, characterization, and application in A549 lung cancer. 62
35734959 2022
15
BDBB: A Novel Beta-Distribution-Based Biclustering Algorithm for Revealing Local Co-Methylation Patterns in Epi-Transcriptome Profiling Data. 62
33764880 2022
16
The effects of functionalized graphene oxide on the thermal and mechanical properties of liquid crystalline polymers. 62
35552585 2022
17
Laminaria japonica cyclic peptides exert anti-colorectal carcinoma effects through apoptosis induction in vitro and in vivo. 62
34935253 2022
18
Neuropsychological Assessment of the Aging Physician: A Review & Commentary. 62
34018429 2022
19
Properties of electrode-supported lipid cubic mesophase films with embedded gramicidin A: structure and ion-transport studies. 62
34942573 2022
20
Structural Characterization and Immunoenhancing Effects of a Polysaccharide from the Soft Coral Lobophytum sarcophytoides. 62
35175461 2022
21
Design, Regulation, and Applications of Soft Actuators Based on Liquid-Crystalline Polymers and Their Composites. 62
35259869 2022
22
Degradation of UV-pretreated polyolefins by latex clearing protein from Streptomyces sp. Strain K30. 62
34619208 2022
23
Fixation of a scapular body fracture in a 5 month old foal using three 4.5/5.0 mm locking compression plates. 62
34866213 2022
24
Balanced lipase interactions for degradation-controlled paclitaxel release from lipid cubic phase formulations. 62
34571316 2022
25
Application of locking compression plates as type 1 external fixators to treat unilateral mandibular fractures in four equids and one dromedary. 62
34787314 2022
26
Flexible Liquid Crystal Polymer Technologies from Microwave to Terahertz Frequencies. 62
35209131 2022
27
NMR spectroscopy of lipidic cubic phases. 62
35340611 2022
28
Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel. 62
34978158 2022
29
Mountain frog species losing out to climate change around the Sichuan Basin. 62
34592288 2022
30
Biomechanical Evaluation of Different Plate Configurations for Midshaft Clavicle Fracture Fixation: Single Plating Compared with Dual Mini-Fragment Plating. 62
35265785 2022
31
Single-cut osteotomy for correction of a complex multiplanar deformity of the radius in a Shetland pony foal. 62
34651322 2022
32
Revision Surgery Using Retrograde Nail versus Replating in Nonunion Distal Femur Fracture Treated with Plate. 62
35694104 2022
33
The Construct and Interpretation of Chelated Coordination Polymers and Their Use in Nanomaterials Research. 62
35990538 2022
34
Using player types to understand cooperative behaviour under economic and sociocultural heterogeneity in common-pool resources: Evidence from lab experiments and agent-based models. 62
35613092 2022
35
Assessment of Functional and Radiological Outcomes of Comminuted Intra-Articular Distal Radius Fracture Treated With Locking Compression Plate. 62
35198305 2022
36
Using a certified electronic health record technology platform to screen, test and refer patients with prediabetes. 62
34870108 2021
37
Plasmid-Encoded H-NS Controls Extracellular Matrix Composition in a Modern Acinetobacter baumannii Urinary Isolate. 62
34398664 2021
38
Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents. 62
34115919 2021
39
Facilitators to referrals to CDC's National Diabetes Prevention Program in primary care practices and pharmacies: DocStyles 2016-2017. 62
33989676 2021
40
Programmable Chromism and Photoluminescence of Spiropyran-Based Liquid Crystalline Polymer with Tunable Glass Transition Temperature. 62
34164902 2021
41
100th Anniversary of Macromolecular Science Viewpoint: Opportunities for Liquid Crystal Polymers in Nanopatterning and Beyond. 62
35549196 2021
42
In vivo study of hypericin-loaded poloxamer-based mucoadhesive in situ gelling liquid crystalline precursor system in a mice model of vulvovaginal candidiasis. 62
33626136 2021
43
Leadless cardiac pacemaker implantations after infected pacemaker system removals in octogenarians. 62
34404987 2021
44
Recurrence with malignancy after endoscopic resection of large colon polyps with high-grade dysplasia: incidence and risk factors. 62
32472496 2021
45
Effect of fish-oil supplementation on breastmilk long-chain polyunsaturated fatty acid concentration: a randomized controlled trial in rural Ethiopia. 62
33159163 2021
46
Cognitive Screening Tools for Late Career Physicians: A Critical Review. 62
32419575 2021
47
Could wild boar be the Trans-Siberian transmitter of African swine fever? 62
32866334 2021
48
Numerical investigation of mechanical behavior of human femoral diaphysis in normal and defective geometry: experimental evaluation. 62
33164564 2021
49
Temporal organisation of the brain's intrinsic motor network: The relationship with circadian phenotype and motor performance. 62
33577933 2021
50
Translating 2D Director Profile to 3D Topography in a Liquid Crystal Polymer. 62
33898203 2021
Sources

Variations for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section
Sources

Expression for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section
Search GEO for disease gene expression data for Lmna-Related Cardiocutaneous Progeria Syndrome.
Sources

Pathways for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section
Sources

GO Terms for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section
Sources

Sources for Lmna-Related Cardiocutaneous Progeria Syndrome

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....