LCPS
MCID: LMN005
MIFTS: 23

Lmna-Related Cardiocutaneous Progeria Syndrome (LCPS)

Categories: Cardiovascular diseases, Rare diseases, Skin diseases

Aliases & Classifications for Lmna-Related Cardiocutaneous Progeria Syndrome

MalaCards integrated aliases for Lmna-Related Cardiocutaneous Progeria Syndrome:

Name: Lmna-Related Cardiocutaneous Progeria Syndrome 59
Lcps 59

Characteristics:

Orphanet epidemiological data:

59
lmna-related cardiocutaneous progeria syndrome
Inheritance: Autosomal dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood; Age of death: adult;

Classifications:

Orphanet: 59  
Rare skin diseases


Summaries for Lmna-Related Cardiocutaneous Progeria Syndrome

MalaCards based summary : Lmna-Related Cardiocutaneous Progeria Syndrome, also known as lcps, is related to legg-calve-perthes disease and rheumatoid arthritis. An important gene associated with Lmna-Related Cardiocutaneous Progeria Syndrome is LMNA (Lamin A/C). Affiliated tissues include skin, heart and bone, and related phenotypes are hypertension and lipoatrophy

Related Diseases for Lmna-Related Cardiocutaneous Progeria Syndrome

Diseases related to Lmna-Related Cardiocutaneous Progeria Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 legg-calve-perthes disease 11.4
2 rheumatoid arthritis 10.0
3 pancreatic cancer 10.0
4 arthritis 10.0
5 bone disease 10.0
6 myopia 10.0
7 cholera 10.0
8 central nervous system lymphoma 10.0
9 neuromuscular disease 10.0
10 primary central nervous system lymphoma 10.0

Graphical network of the top 20 diseases related to Lmna-Related Cardiocutaneous Progeria Syndrome:



Diseases related to Lmna-Related Cardiocutaneous Progeria Syndrome

Symptoms & Phenotypes for Lmna-Related Cardiocutaneous Progeria Syndrome

Human phenotypes related to Lmna-Related Cardiocutaneous Progeria Syndrome:

59 32 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertension 59 32 hallmark (90%) Very frequent (99-80%) HP:0000822
2 lipoatrophy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100578
3 emphysema 59 32 hallmark (90%) Very frequent (99-80%) HP:0002097
4 hypertriglyceridemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002155
5 congestive heart failure 59 32 hallmark (90%) Very frequent (99-80%) HP:0001635
6 premature graying of hair 59 32 hallmark (90%) Very frequent (99-80%) HP:0002216
7 mitral regurgitation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001653
8 mitral valve calcification 59 32 hallmark (90%) Very frequent (99-80%) HP:0004382
9 hypercholesterolemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003124
10 intracranial hemorrhage 59 32 hallmark (90%) Very frequent (99-80%) HP:0002170
11 abnormality of the pulmonary artery 59 32 hallmark (90%) Very frequent (99-80%) HP:0004414
12 sparse hair 59 32 hallmark (90%) Very frequent (99-80%) HP:0008070
13 absent eyelashes 59 32 hallmark (90%) Very frequent (99-80%) HP:0000561
14 aortic valve stenosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001650
15 squamous cell carcinoma of the skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0006739
16 abnormality of the intrahepatic bile duct 59 32 hallmark (90%) Very frequent (99-80%) HP:0011040
17 absent eyebrow 59 32 hallmark (90%) Very frequent (99-80%) HP:0002223
18 alopecia universalis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002289
19 scleroderma 59 32 hallmark (90%) Very frequent (99-80%) HP:0100324
20 ventricular hypertrophy 59 32 hallmark (90%) Very frequent (99-80%) HP:0001714
21 pulmonary carcinoid tumor 59 32 hallmark (90%) Very frequent (99-80%) HP:0030445
22 premature skin wrinkling 59 32 hallmark (90%) Very frequent (99-80%) HP:0100678
23 basal cell carcinoma 59 32 hallmark (90%) Very frequent (99-80%) HP:0002671
24 aortic atherosclerosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0012397
25 papillary renal cell carcinoma 59 32 hallmark (90%) Very frequent (99-80%) HP:0006766
26 aortic root dilatation 59 Very frequent (99-80%)
27 coronary atherosclerosis 59 Very frequent (99-80%)
28 aortic root aneurysm 32 hallmark (90%) HP:0002616
29 coronary artery atherosclerosis 32 hallmark (90%) HP:0001677

Drugs & Therapeutics for Lmna-Related Cardiocutaneous Progeria Syndrome

Search Clinical Trials , NIH Clinical Center for Lmna-Related Cardiocutaneous Progeria Syndrome

Genetic Tests for Lmna-Related Cardiocutaneous Progeria Syndrome

Anatomical Context for Lmna-Related Cardiocutaneous Progeria Syndrome

MalaCards organs/tissues related to Lmna-Related Cardiocutaneous Progeria Syndrome:

41
Skin, Heart, Bone

Publications for Lmna-Related Cardiocutaneous Progeria Syndrome

Articles related to Lmna-Related Cardiocutaneous Progeria Syndrome:

# Title Authors Year
1
Legg-Calvé-Perthes syndrome (LCPS): an up-to-date critical review Charles W. Goff, MD CORR 1962;22:93-107. ( 22806262 )
2012
2
Recent developments in infant formulae: 1--The addition of LCPs. ( 10197022 )
1998
3
Legg-Calve-Perthes syndrome (LCPS). An up-to-date critical review. ( 13899540 )
1962

Variations for Lmna-Related Cardiocutaneous Progeria Syndrome

Expression for Lmna-Related Cardiocutaneous Progeria Syndrome

Search GEO for disease gene expression data for Lmna-Related Cardiocutaneous Progeria Syndrome.

Pathways for Lmna-Related Cardiocutaneous Progeria Syndrome

GO Terms for Lmna-Related Cardiocutaneous Progeria Syndrome

Sources for Lmna-Related Cardiocutaneous Progeria Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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