Aliases & Classifications for Lobular Neoplasia

MalaCards integrated aliases for Lobular Neoplasia:

Name: Lobular Neoplasia 12 15 73
Lobular Carcinoma in Situ of Breast 73
Non-Infiltrating Lobular Carcinoma 73
Lobular Intraepithelial Neoplasia 12
Lobular Carcinoma in Situ 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3010
NCIt 50 C27939
ICD10 33 D05.0

Summaries for Lobular Neoplasia

MalaCards based summary : Lobular Neoplasia, also known as lobular carcinoma in situ of breast, is related to ductal carcinoma in situ and breast cancer. An important gene associated with Lobular Neoplasia is CDH1 (Cadherin 1), and among its related pathways/superpathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. The drugs Tamoxifen and Antineoplastic Agents, Hormonal have been mentioned in the context of this disorder. Affiliated tissues include bone and breast, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and cellular

Wikipedia : 76 Lobular neoplasia can refer... more...

Related Diseases for Lobular Neoplasia

Diseases related to Lobular Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 ductal carcinoma in situ 28.0 BRCA1 CDH1 ERBB2 ESR1 MUC1
2 breast cancer 25.5 BRCA1 CDH1 CTNNB1 ERBB2 ESR1 ESR2
3 gastric signet ring cell adenocarcinoma 10.7 CDH1 ESR1
4 progesterone resistance 10.7 ESR1 ESR2
5 large intestine adenocarcinoma 10.7 CDH1 CTNNB1
6 goblet cell carcinoid 10.7 CDH1 CTNNB1
7 gender identity disorder 10.7 ESR1 ESR2
8 estrogen excess 10.6 ESR1 ESR2
9 dental fluorosis 10.6 ESR1 ESR2
10 endometriosis of ovary 10.6 ESR1 ESR2
11 vaginitis 10.5 ESR1 ESR2
12 gastric cancer, hereditary diffuse 10.5 CDH1 CTNNA1
13 gastric diffuse adenocarcinoma 10.5 CDH1 CTNNA1
14 synchronous bilateral breast carcinoma 10.4 BRCA1 ESR1
15 glycogen-rich clear cell breast carcinoma 10.4 BRCA1 ESR1
16 parotid gland cancer 10.4 CDH1 ESR2
17 microinvasive gastric cancer 10.4 CDH1 CTNNA1
18 biphasic synovial sarcoma 10.4 CDH1 MUC1
19 endometrial mucinous adenocarcinoma 10.3 ESR1 MUC1
20 pelvic organ prolapse 10.3 ESR1 ESR2
21 syringoma 10.3 ESR1 MUC1
22 postmenopausal atrophic vaginitis 10.3 ESR1 ESR2 PRLR
23 lymphoepithelioma-like carcinoma 10.3 CDH1 MUC1
24 adenomyoma 10.3 CTNNB1 MUC1
25 chondroid chordoma 10.2 CDH1 MUC1
26 pancreatic mucinous cystadenoma 10.2 ESR1 MUC1
27 sclerosing hemangioma 10.2 CTNNB1 MUC1
28 breast cystic hypersecretory carcinoma 10.2 CDH1 ERBB2
29 glassy cell carcinoma of the cervix 10.2 ERBB2 ESR1
30 epstein-barr virus-associated gastric carcinoma 10.1 CDH1 CTNNB1
31 comedo carcinoma 10.1 ERBB2 ESR1
32 peritoneal mesothelioma 10.1 ESR1 MUC1
33 oncocytic breast carcinoma 10.1 ERBB2 ESR1
34 diffuse gastric cancer 10.1 CDH1 CTNNA1
35 polymorphous low-grade adenocarcinoma 10.1 CTNNB1 MUC1
36 breast adenoid cystic carcinoma 10.1 ERBB2 ESR1
37 uterine body mixed cancer 10.0 ERBB2 ESR2
38 uterine corpus cancer 10.0 ERBB2 ESR1
39 luminal breast carcinoma 10.0 ERBB2 ESR1
40 breast benign neoplasm 10.0 ERBB2 ESR1
41 thoracic benign neoplasm 10.0 ERBB2 ESR1
42 gastrointestinal system benign neoplasm 10.0 CDH1 CTNNB1
43 signet ring cell adenocarcinoma 10.0 CDH1 CTNNB1 MUC1
44 mixed cell type cancer 10.0 ERBB2 ESR1
45 sarcoma, synovial 10.0 CDH1 CTNNB1 MUC1
46 mesothelioma, malignant 10.0 CDH1 CTNNB1 MUC1
47 breast fibroadenoma 10.0
48 cystadenofibroma 10.0 BRCA1 MUC1
49 bile duct adenocarcinoma 9.9 CDH1 MUC1
50 hidradenocarcinoma 9.9 ERBB2 ESR1

Graphical network of the top 20 diseases related to Lobular Neoplasia:



Diseases related to Lobular Neoplasia

Symptoms & Phenotypes for Lobular Neoplasia

GenomeRNAi Phenotypes related to Lobular Neoplasia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.92 CTNNA1 CTNNB1 ERBB2 MUC1

MGI Mouse Phenotypes related to Lobular Neoplasia:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 PRLR CTNNA1 BRCA1 CTNNB1 CDH1 ERBB2
2 endocrine/exocrine gland MP:0005379 10.16 PRLR CTNNA1 BRCA1 CTNNB1 CDH1 ERBB2
3 growth/size/body region MP:0005378 10.15 PRLR HSP90AA1 CTNNA1 BRCA1 CTNNB1 CDH1
4 behavior/neurological MP:0005386 10.11 PRLR HSP90AA1 BRCA1 CTNNB1 ESR1 ERBB2
5 cardiovascular system MP:0005385 10.1 CTNNA1 BRCA1 CTNNB1 CDH1 ERBB2 ESR2
6 integument MP:0010771 10.08 PRLR CTNNA1 BRCA1 CTNNB1 CDH1 ERBB2
7 embryo MP:0005380 10.07 PRLR CTNNA1 BRCA1 CTNNB1 CDH1 ERBB2
8 limbs/digits/tail MP:0005371 10.06 PRLR CTNNA1 BRCA1 CTNNB1 ESR2 ESR1
9 mortality/aging MP:0010768 10.03 HSP90AA1 CDH1 CTNNA1 BRCA1 CTNNB1 ERBB2
10 digestive/alimentary MP:0005381 10.01 BRCA1 CTNNB1 CDH1 ERBB2 ESR2 ESR1
11 neoplasm MP:0002006 9.97 PRLR CTNNA1 BRCA1 CTNNB1 CDH1 ESR2
12 muscle MP:0005369 9.88 CTNNA1 BRCA1 CTNNB1 ERBB2 ESR2 ESR1
13 nervous system MP:0003631 9.87 PRLR CTNNA1 BRCA1 CTNNB1 ESR1 ERBB2
14 reproductive system MP:0005389 9.76 PRLR BRCA1 CTNNB1 CDH1 ERBB2 ESR2
15 normal MP:0002873 9.73 BRCA1 CTNNB1 CDH1 ERBB2 ESR2 ESR1
16 respiratory system MP:0005388 9.35 BRCA1 ESR1 ERBB2 ESR2 CTNNB1
17 skeleton MP:0005390 9.23 PRLR CTNNA1 BRCA1 CTNNB1 ERBB2 ESR2

Drugs & Therapeutics for Lobular Neoplasia

Drugs for Lobular Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 3 10540-29-1 2733526
2 Antineoplastic Agents, Hormonal Phase 3
3 Bone Density Conservation Agents Phase 3
4 Estrogen Antagonists Phase 3
5 Estrogen Receptor Modulators Phase 3
6 Estrogens Phase 3
7 Hormone Antagonists Phase 3
8 Hormones Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 Selective Estrogen Receptor Modulators Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Low Dose Tamoxifen in Women With Breast Intraepithelial Neoplasia Active, not recruiting NCT01357772 Phase 3 Tamoxifen;placebo
2 Upstaging of ALH/LCIS Found on Core Biopsy Based on Subsequent Excisional Biopsy Completed NCT00146536

Search NIH Clinical Center for Lobular Neoplasia

Genetic Tests for Lobular Neoplasia

Anatomical Context for Lobular Neoplasia

MalaCards organs/tissues related to Lobular Neoplasia:

41
Bone, Breast

Publications for Lobular Neoplasia

Articles related to Lobular Neoplasia:

(show top 50) (show all 90)
# Title Authors Year
1
Observation versus excision of lobular neoplasia on core needle biopsy of the breast. ( 29299726 )
2018
2
Sonographic Appearance of Lesions Diagnosed as Lobular Neoplasia at Sonographically Guided Biopsies. ( 28075608 )
2017
3
Is the outcome at surgery different when flat epithelial atypia and lobular neoplasia are found in association at biopsy? ( 28118035 )
2017
4
Lobular Neoplasia and Atypical Ductal Hyperplasia on Core Biopsy: Current Surgical Management Recommendations. ( 28766203 )
2017
5
Lobular neoplasia diagnosed on breast Core biopsy: frequency of carcinoma on excision and implications for management. ( 27806840 )
2016
6
When pathological and radiological correlation is achieved, excision of fibroadenoma with lobular neoplasia on core biopsy is not warranted. ( 27718416 )
2016
7
Lobular Neoplasia: Another Reset in Management? ( 26676981 )
2016
8
Surgical Outcomes of Lobular Neoplasia Diagnosed in Core Biopsy: Prospective Study ofA 316 Cases. ( 27425222 )
2016
9
Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade: a study of 63 cases from four different institutions. ( 26564004 )
2016
10
The radiological features, diagnosis and management of screen-detected lobular neoplasia of the breast: Findings from the Sloane Project. ( 27060553 )
2016
11
CD10-positive myoepithelial cells are usually prominent around in situ lobular neoplasia of the breast and much less prominent or absent in DCIS. ( 26862059 )
2016
12
Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In-situ in Patients with Lobular Neoplasia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 020). ( 26542585 )
2015
13
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. ( 24441664 )
2014
14
Lobular neoplasia: morphology and management. ( 25268198 )
2014
15
Mucinous breast carcinoma with a lobular neoplasia component: a subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation. ( 24888775 )
2014
16
Lobular neoplasia. ( 24882347 )
2014
17
Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. ( 24948027 )
2014
18
Evolving concepts in breast lobular neoplasia and invasive lobular carcinoma, and their impact on imaging methods. ( 24633840 )
2014
19
Lobular neoplasia: what does it mean and how should it be treated? ( 23617527 )
2013
20
Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry. ( 23759937 )
2013
21
Classic lobular neoplasia on core biopsy: a clinical and radio-pathologic correlation study with follow-up excision biopsy. ( 23307062 )
2013
22
Low frequency of cancer occurrence in same breast quadrant diagnosed with lobular neoplasia at percutaneous needle biopsy. ( 22344406 )
2012
23
Hsa-miR-375 is differentially expressed during breast lobular neoplasia and promotes loss of mammary acinar polarity. ( 21953071 )
2012
24
Cadherin-catenin complex dissociation in lobular neoplasia of the breast. ( 22080244 )
2012
25
Lobular lesions of the breast: imaging findings of lobular neoplasia and invasive lobular carcinoma. ( 22324264 )
2012
26
Long-term follow-up of lobular neoplasia (atypical lobular hyperplasia/lobular carcinoma in situ) diagnosed on core needle biopsy. ( 22847124 )
2012
27
Is excisional biopsy required after a breast core biopsy yields lobular neoplasia? ( 22997389 )
2012
28
Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification. ( 22706860 )
2012
29
Breast-specific gamma imaging in the detection of atypical ductal hyperplasia and lobular neoplasia. ( 22578225 )
2012
30
Surgical outcome of biopsy-proven lobular neoplasia: is there any difference between lobular carcinoma in situ and atypical lobular hyperplasia? ( 22268170 )
2012
31
Lobular neoplasia: frequency and association with other breast lesions. ( 21827679 )
2011
32
Amplification of the prolactin receptor gene in mammary lobular neoplasia. ( 20658264 )
2011
33
In situ lobular neoplasia of the breast with marked myoepithelial proliferation. ( 21707709 )
2011
34
Lobular neoplasia found on breast biopsy: marker of increased risk of malignancy or direct pre-cancerous lesion? ( 22038220 )
2011
35
Lobular neoplasia: how to manage with partial understanding. ( 22106558 )
2011
36
Management of in situ lobular neoplasia detected on needle core biopsy of breast. ( 20972243 )
2010
37
Lobular neoplasia: morphology, biological potential and management in core biopsies. ( 20436498 )
2010
38
Lobular neoplasia displaying central necrosis: a potential diagnostic pitfall. ( 20359832 )
2010
39
Lobular neoplasia of the breast. ( 20701604 )
2010
40
Lobular neoplasia: evolution of its significance and morphologic spectrum. ( 20484286 )
2010
41
Lobular neoplasia of the breast: 68 years on. ( 19089737 )
2009
42
Lobular neoplasia of the breast: an update. ( 19642738 )
2009
43
Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia. ( 19294736 )
2009
44
Concurrent lobular neoplasia increases the risk of ipsilateral breast cancer recurrence in patients with ductal carcinoma in situ treated with breast-conserving therapy. ( 19170233 )
2009
45
Is excisional biopsy indicated for patients with lobular neoplasia diagnosed on percutaneous core needle biopsy of the breast? ( 19969131 )
2009
46
Sampling lobular neoplasia of the breast: underestimation despite technical success? ( 19466452 )
2009
47
Lobular neoplasia: core needle breast biopsy underestimation of malignancy in relation to radiologic and pathologic features. ( 18619840 )
2008
48
In situ and invasive lobular neoplasia of the breast. ( 18171417 )
2008
49
Lobular neoplasia at percutaneous breast biopsy: variables associated with carcinoma at surgical excision. ( 18287433 )
2008
50
Heat shock protein90 in lobular neoplasia of the breast. ( 18957107 )
2008

Variations for Lobular Neoplasia

Cosmic variations for Lobular Neoplasia:

9
(show top 50) (show all 1434)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6949530 ZRSR2 breast,NS,carcinoma,lobular carcinoma c.772-1G>C p.? 23:15818586-15818586 7
2 COSM6958693 ZFHX3 breast,NS,carcinoma,lobular carcinoma c.7262C>G p.S2421* 16:72795420-72795420 7
3 COSM5037959 ZFHX3 breast,NS,carcinoma,lobular carcinoma c.4556C>G p.S1519* 16:72798126-72798126 7
4 COSM6953298 ZFHX3 breast,NS,carcinoma,lobular carcinoma c.9220C>T p.Q3074* 16:72793462-72793462 7
5 COSM6906826 YES1 breast,NS,carcinoma,lobular carcinoma c.1090G>C p.D364H 18:739782-739782 7
6 COSM6921648 YAP1 breast,NS,carcinoma,lobular carcinoma c.952C>T p.Q318* 11:102223703-102223703 7
7 COSM3839782 XPO1 breast,NS,carcinoma,lobular carcinoma c.1160C>G p.S387C 2:61493979-61493979 7
8 COSM6923776 XPO1 breast,NS,carcinoma,lobular carcinoma c.2260G>T p.E754* 2:61488218-61488218 7
9 COSM6953971 XIAP breast,NS,carcinoma,lobular carcinoma c.1240C>G p.L414V 23:123900633-123900633 7
10 COSM638 WNK1 breast,NS,carcinoma,lobular carcinoma c.1255G>C p.E419Q 12:830104-830104 7
11 COSM637 WNK1 breast,NS,carcinoma,lobular carcinoma c.6569C>G p.S2190C 12:900596-900596 7
12 COSM18026 VHL breast,NS,carcinoma,lobular carcinoma c.562C>G p.L188V 3:10149885-10149885 7
13 COSM17721 VHL breast,NS,carcinoma,lobular carcinoma c.241C>T p.P81S 3:10142088-10142088 7
14 COSM51319 USP28 breast,NS,carcinoma,lobular carcinoma c.2050G>A p.D684N 11:113809177-113809177 7
15 COSM6963846 TSHR breast,NS,carcinoma,lobular carcinoma c.1283C>T p.A428V 14:81143341-81143341 7
16 COSM6971312 TSC2 breast,NS,carcinoma,lobular carcinoma c.429C>G p.F143L 16:2054388-2054388 7
17 COSM6911141 TSC2 breast,NS,carcinoma,lobular carcinoma c.700G>A p.E234K 16:2056695-2056695 7
18 COSM6929739 TSC2 breast,NS,carcinoma,lobular carcinoma c.3042C>G p.S1014R 16:2079107-2079107 7
19 COSM6909235 TSC2 breast,NS,carcinoma,lobular carcinoma c.1615C>T p.L539F 16:2065534-2065534 7
20 COSM6958690 TSC2 breast,NS,carcinoma,lobular carcinoma c.3887C>G p.S1296C 16:2083698-2083698 7
21 COSM6971309 TSC1 breast,NS,carcinoma,lobular carcinoma c.3208G>A p.A1070T 9:132896522-132896522 7
22 COSM6188 TRIM33 breast,NS,carcinoma,lobular carcinoma c.2968-1G>C p.? 1:114399610-114399610 7
23 COSM6971833 TRAF7 breast,NS,carcinoma,lobular carcinoma c.104G>A p.G35E 16:2165901-2165901 7
24 COSM6926297 TP63 breast,NS,carcinoma,lobular carcinoma c.1432G>C p.V478L 3:189886476-189886476 7
25 COSM3408510 TP63 breast,NS,carcinoma,lobular carcinoma c.679G>A p.A227T 3:189864331-189864331 7
26 COSM6940226 TP63 breast,NS,carcinoma,lobular carcinoma c.1865G>T p.S622I 3:189894324-189894324 7
27 COSM6958680 TP63 breast,NS,carcinoma,lobular carcinoma c.1079G>C p.R360T 3:189868666-189868666 7
28 COSM10768 TP53 breast,NS,carcinoma,lobular carcinoma c.535C>T p.H179Y 17:7675077-7675077 7
29 COSM43606 TP53 breast,NS,carcinoma,lobular carcinoma c.734G>A p.G245D 17:7674229-7674229 7
30 COSM10656 TP53 breast,NS,carcinoma,lobular carcinoma c.742C>T p.R248W 17:7674221-7674221 7
31 COSM10812 TP53 breast,NS,carcinoma,lobular carcinoma c.722C>T p.S241F 17:7674241-7674241 7
32 COSM44599 TP53 breast,NS,carcinoma,lobular carcinoma c.587G>A p.R196Q 17:7674944-7674944 7
33 COSM10719 TP53 breast,NS,carcinoma,lobular carcinoma c.811G>A p.E271K 17:7673809-7673809 7
34 COSM10733 TP53 breast,NS,carcinoma,lobular carcinoma c.574C>T p.Q192* 17:7674957-7674957 7
35 COSM44169 TP53 breast,NS,carcinoma,lobular carcinoma c.614A>C p.Y205S 17:7674917-7674917 7
36 COSM11073 TP53 breast,NS,carcinoma,lobular carcinoma c.1024C>T p.R342* 17:7670685-7670685 7
37 COSM43695 TP53 breast,NS,carcinoma,lobular carcinoma c.748C>T p.P250S 17:7674215-7674215 7
38 COSM11552 TP53 breast,NS,carcinoma,lobular carcinoma c.775G>T p.D259Y 17:7674188-7674188 7
39 COSM44268 TP53 breast,NS,carcinoma,lobular carcinoma c.559+1G>T p.? 17:7675052-7675052 7
40 COSM10654 TP53 breast,NS,carcinoma,lobular carcinoma c.637C>T p.R213* 17:7674894-7674894 7
41 COSM10648 TP53 breast,NS,carcinoma,lobular carcinoma c.524G>A p.R175H 17:7675088-7675088 7
42 COSM46103 TP53 breast,NS,carcinoma,lobular carcinoma c.319T>G p.Y107D 17:7676050-7676050 7
43 COSM10722 TP53 breast,NS,carcinoma,lobular carcinoma c.853G>A p.E285K 17:7673767-7673767 7
44 COSM10728 TP53 breast,NS,carcinoma,lobular carcinoma c.839G>A p.R280K 17:7673781-7673781 7
45 COSM11059 TP53 breast,NS,carcinoma,lobular carcinoma c.713G>A p.C238Y 17:7674250-7674250 7
46 COSM10704 TP53 breast,NS,carcinoma,lobular carcinoma c.844C>T p.R282W 17:7673776-7673776 7
47 COSM10726 TP53 breast,NS,carcinoma,lobular carcinoma c.856G>A p.E286K 17:7673764-7673764 7
48 COSM10867 TP53 breast,NS,carcinoma,lobular carcinoma c.797G>A p.G266E 17:7673823-7673823 7
49 COSM43597 TP53 breast,NS,carcinoma,lobular carcinoma c.538G>T p.E180* 17:7675074-7675074 7
50 COSM11196 TP53 breast,NS,carcinoma,lobular carcinoma c.734G>T p.G245V 17:7674229-7674229 7

Expression for Lobular Neoplasia

Search GEO for disease gene expression data for Lobular Neoplasia.

Pathways for Lobular Neoplasia

Pathways related to Lobular Neoplasia according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 BRCA1 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
2
Show member pathways
13.1 CDH1 CTNNB1 ERBB2 ESR1 ESR2 HSP90AA1
3
Show member pathways
12.82 BRCA1 CTNNB1 ERBB2 HSP90AA1 PRLR
4
Show member pathways
12.7 CDH1 CTNNA1 CTNNB1 ERBB2 HSP90AA1
5
Show member pathways
12.59 BRCA1 CDH1 ERBB2 ESR1 ESR2
6
Show member pathways
12.51 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
7
Show member pathways
12.36 ERBB2 ESR1 ESR2 PRLR
8
Show member pathways
12.27 BRCA1 CTNNB1 ESR1 HSP90AA1
9 12.22 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1 ESR2
10
Show member pathways
12.21 CDH1 CTNNB1 ERBB2 HSP90AA1 MUC1
11
Show member pathways
12.17 ERBB2 ESR1 ESR2
12 12.14 CTNNB1 ERBB2 ESR1
13
Show member pathways
12.11 CDH1 CTNNA1 CTNNB1
14
Show member pathways
12.06 CTNNA1 CTNNB1 HSP90AA1
15 12 CDH1 CTNNA1 CTNNB1
16 11.95 CDH1 CTNNA1 CTNNB1
17 11.95 BRCA1 CDH1 CTNNB1 ESR1
18
Show member pathways
11.83 BRCA1 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
19
Show member pathways
11.82 ERBB2 ESR1 PRLR
20 11.79 CDH1 CTNNA1 CTNNB1 MUC1
21 11.64 CDH1 CTNNA1 CTNNB1
22 11.36 CDH1 CTNNA1 CTNNB1
23 11.31 CDH1 CTNNA1 CTNNB1 ERBB2
24 11.29 CDH1 CTNNA1 CTNNB1
25 11.27 CDH1 CTNNA1 CTNNB1
26 11.22 ESR1 HSP90AA1
27 11.2 CTNNA1 CTNNB1
28 11.18 CTNNA1 CTNNB1
29 11.18 ESR2 PRLR
30 11.18 CDH1 CTNNA1 CTNNB1
31 11.16 CDH1 ERBB2
32 11.14 CTNNB1 ERBB2
33 11.13 CDH1 CTNNA1 CTNNB1
34 11.11 ESR1 ESR2
35 11.07 ESR1 ESR2
36 11.05 ESR1 HSP90AA1
37 11 ESR1 ESR2
38 10.94 CDH1 CTNNA1 CTNNB1
39 10.91 CDH1 CTNNA1
40 10.55 CDH1 CTNNA1 CTNNB1
41 10.15 ESR1 ESR2

GO Terms for Lobular Neoplasia

Cellular components related to Lobular Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.81 BRCA1 CDH1 CTNNA1 CTNNB1 ERBB2 ESR1
2 perinuclear region of cytoplasm GO:0048471 9.73 CDH1 CTNNB1 ERBB2 HSP90AA1
3 protein-containing complex GO:0032991 9.71 BRCA1 CTNNB1 ESR1 HSP90AA1
4 lamellipodium GO:0030027 9.54 CDH1 CTNNA1 CTNNB1
5 cell-cell adherens junction GO:0005913 9.43 CDH1 CTNNA1 CTNNB1
6 apical junction complex GO:0043296 9.32 CDH1 CTNNB1
7 catenin complex GO:0016342 9.13 CDH1 CTNNA1 CTNNB1
8 flotillin complex GO:0016600 8.8 CDH1 CTNNA1 CTNNB1

Biological processes related to Lobular Neoplasia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.63 ERBB2 ESR1 HSP90AA1
2 positive regulation of transcription, DNA-templated GO:0045893 9.55 BRCA1 CDH1 CTNNB1 ESR1 ESR2
3 ERBB2 signaling pathway GO:0038128 9.54 ERBB2 HSP90AA1
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.54 CTNNB1 ESR1 ESR2
5 regulation of angiogenesis GO:0045765 9.52 CTNNB1 ERBB2
6 positive regulation of telomerase activity GO:0051973 9.51 CTNNB1 HSP90AA1
7 positive regulation of muscle cell differentiation GO:0051149 9.49 CTNNA1 CTNNB1
8 intracellular estrogen receptor signaling pathway GO:0030520 9.48 ESR1 ESR2
9 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.43 BRCA1 MUC1
10 response to estrogen GO:0043627 9.43 BRCA1 CTNNA1 ESR1
11 positive regulation of histone H3-K4 methylation GO:0051571 9.4 BRCA1 CTNNB1
12 entry of bacterium into host cell GO:0035635 9.32 CDH1 CTNNB1
13 adherens junction organization GO:0034332 9.13 CDH1 CTNNA1 CTNNB1
14 cellular response to indole-3-methanol GO:0071681 8.92 BRCA1 CDH1 CTNNA1 CTNNB1

Molecular functions related to Lobular Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 BRCA1 CTNNB1 ESR1 ESR2
2 beta-catenin binding GO:0008013 9.54 CDH1 CTNNA1 ESR1
3 disordered domain specific binding GO:0097718 9.48 CTNNB1 HSP90AA1
4 steroid binding GO:0005496 9.46 ESR1 ESR2
5 gamma-catenin binding GO:0045295 9.43 CDH1 CTNNA1
6 identical protein binding GO:0042802 9.43 CDH1 CTNNA1 ERBB2 ESR1 ESR2 HSP90AA1
7 nitric-oxide synthase regulator activity GO:0030235 9.32 ESR1 HSP90AA1
8 estrogen receptor activity GO:0030284 9.26 ESR1 ESR2
9 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
10 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Lobular Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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