MCID: LCL011
MIFTS: 15

Localized Hypertrophic Neuropathy

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Localized Hypertrophic Neuropathy

MalaCards integrated aliases for Localized Hypertrophic Neuropathy:

Name: Localized Hypertrophic Neuropathy 53
Onion Whorl Disease 53

Classifications:



Summaries for Localized Hypertrophic Neuropathy

NIH Rare Diseases : 53 Localized hypertrophic neuropathy is a nerve condition in which nerve cells increase in number and form bundles that look like onion bulbs.  This condition affects one nerve, usually in an arm or leg.  The symptoms of this condition include muscle weakness, numbness, and decreased reflexes in the affected limb.  Symptoms slowly get worse over time.  The cause of this condition is unknown, but some researchers believe it might be a type of tumor, while others believe it might be an unusual reaction to injury.

MalaCards based summary : Localized Hypertrophic Neuropathy, also known as onion whorl disease, is related to perineurioma and intraneural perineurioma. An important gene associated with Localized Hypertrophic Neuropathy is MUC1 (Mucin 1, Cell Surface Associated).

Related Diseases for Localized Hypertrophic Neuropathy

Diseases related to Localized Hypertrophic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 perineurioma 29.7 MUC1 S100B
2 intraneural perineurioma 29.1 MUC1 S100B
3 neurofibroma 29.0 MUC1 S100B
4 neuropathy 10.4
5 sclerosing perineurioma 9.9 MUC1 S100B
6 intracranial cysts 9.9 MUC1 S100B
7 reticular perineurioma 9.8 MUC1 S100B
8 non-functioning pituitary adenoma 9.8 MUC1 S100B
9 epithelioid malignant peripheral nerve sheath tumor 9.8 MUC1 S100B
10 ossifying fibromyxoid tumor 9.8 MUC1 S100B
11 fibrous meningioma 9.8 MUC1 S100B
12 chordoid meningioma 9.8 MUC1 S100B
13 syringocystadenoma papilliferum 9.8 MUC1 S100B
14 eccrine porocarcinoma 9.8 MUC1 S100B
15 spindle cell rhabdomyosarcoma 9.8 MUC1 S100B
16 aggressive digital papillary adenocarcinoma 9.8 MUC1 S100B
17 myxopapillary ependymoma 9.8 MUC1 S100B
18 monophasic synovial sarcoma 9.8 MUC1 S100B
19 chordoid glioma 9.8 MUC1 S100B
20 spiradenoma 9.8 MUC1 S100B
21 syringoma 9.8 MUC1 S100B
22 pleomorphic liposarcoma 9.8 MUC1 S100B
23 anaplastic ependymoma 9.8 MUC1 S100B
24 spindle cell sarcoma 9.8 MUC1 S100B
25 functioning pituitary adenoma 9.8 MUC1 S100B
26 papilloma of choroid plexus 9.7 MUC1 S100B
27 meningeal melanocytoma 9.7 MUC1 S100B
28 dendritic cell tumor 9.7 MUC1 S100B
29 connective tissue benign neoplasm 9.7
30 cerebral primitive neuroectodermal tumor 9.7 MUC1 S100B
31 hemangiopericytoma, malignant 9.7 MUC1 S100B
32 polymorphous low-grade adenocarcinoma 9.7 MUC1 S100B
33 malignant fibroxanthoma 9.7 MUC1 S100B
34 optic nerve glioma 9.6 MUC1 S100B
35 pilomatrixoma 9.6 MUC1 S100B
36 atypical teratoid rhabdoid tumor 9.6 MUC1 S100B
37 ependymoma 9.6 MUC1 S100B
38 hemangioblastoma 9.5 MUC1 S100B
39 pleomorphic adenoma 9.5 MUC1 S100B
40 chordoma 9.4 MUC1 S100B
41 malignant peripheral nerve sheath tumor 9.3 MUC1 S100B
42 adenoid cystic carcinoma 9.2 MUC1 S100B
43 meningioma, familial 9.0 MUC1 S100B

Graphical network of the top 20 diseases related to Localized Hypertrophic Neuropathy:



Diseases related to Localized Hypertrophic Neuropathy

Symptoms & Phenotypes for Localized Hypertrophic Neuropathy

Drugs & Therapeutics for Localized Hypertrophic Neuropathy

Search Clinical Trials , NIH Clinical Center for Localized Hypertrophic Neuropathy

Genetic Tests for Localized Hypertrophic Neuropathy

Anatomical Context for Localized Hypertrophic Neuropathy

Publications for Localized Hypertrophic Neuropathy

Articles related to Localized Hypertrophic Neuropathy:

(show all 19)
# Title Authors Year
1
Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings. ( 22832864 )
2012
2
Localized hypertrophic neuropathy: a case report and review of the literature. ( 19216221 )
2009
3
Radial nerve palsy owing to localized hypertrophic neuropathy (intraneural perineurioma) in early childhood. ( 15032391 )
2004
4
Localized hypertrophic neuropathy: magnetic resonance imaging findings and long-term follow-up. ( 9883854 )
1999
5
Localized hypertrophic neuropathy involving the inferior alveolar nerve. ( 9915404 )
1999
6
Resection and graft repair for localized hypertrophic neuropathy. ( 9657192 )
1998
7
Localized hypertrophic neuropathy. ( 8035630 )
1994
8
Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. ( 1497116 )
1992
9
Localized hypertrophic neuropathy (LHN). ( 1332008 )
1992
10
Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy. ( 1320324 )
1992
11
Localized hypertrophic neuropathy: possible focal perineurial barrier defect. ( 2655369 )
1989
12
The immunohistochemical demonstration of early perineurial change in the development of localized hypertrophic neuropathy. ( 2847973 )
1988
13
Localized hypertrophic neuropathy--a rare and clinically almost unknown syndrome. ( 3791730 )
1986
14
Localized hypertrophic neuropathy: a perineurialoma? ( 3995812 )
1985
15
Localized hypertrophic neuropathy--a rare, clinically almost unknown syndrome. ( 6094068 )
1984
16
Perineurioma (localized hypertrophic neuropathy). ( 6329127 )
1984
17
Perineurioma as the cause of localized hypertrophic neuropathy. ( 6775221 )
1980
18
Letter: Localized hypertrophic neuropathy, intraneural tumour, or chronic nerve entrapment? ( 47973 )
1975
19
Macrodactyly and localized hypertrophic neuropathy. ( 4367276 )
1974

Variations for Localized Hypertrophic Neuropathy

Expression for Localized Hypertrophic Neuropathy

Search GEO for disease gene expression data for Localized Hypertrophic Neuropathy.

Pathways for Localized Hypertrophic Neuropathy

GO Terms for Localized Hypertrophic Neuropathy

Sources for Localized Hypertrophic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
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33 ICD10
34 ICD10 via Orphanet
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44 MeSH
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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