MCID: LCL011
MIFTS: 14

Localized Hypertrophic Neuropathy

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Localized Hypertrophic Neuropathy

MalaCards integrated aliases for Localized Hypertrophic Neuropathy:

Name: Localized Hypertrophic Neuropathy 20
Onion Whorl Disease 20

Classifications:



Summaries for Localized Hypertrophic Neuropathy

GARD : 20 Localized hypertrophic neuropathy is a nerve condition in which nerve cells increase in number and form bundles that look like onion bulbs. This condition affects one nerve, usually in an arm or leg. The symptoms of this condition include muscle weakness, numbness, and decreased reflexes in the affected limb. Symptoms slowly get worse over time. The cause of this condition is unknown, but some researchers believe it might be a type of tumor, while others believe it might be an unusual reaction to injury.

MalaCards based summary : Localized Hypertrophic Neuropathy, also known as onion whorl disease, is related to perineurioma and intraneural perineurioma. An important gene associated with Localized Hypertrophic Neuropathy is MUC1 (Mucin 1, Cell Surface Associated). Affiliated tissues include pituitary.

Related Diseases for Localized Hypertrophic Neuropathy

Diseases related to Localized Hypertrophic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 perineurioma 30.3 S100B MUC1
2 intraneural perineurioma 30.1 S100B MUC1
3 neurofibroma 29.8 S100B MUC1
4 neuropathy 10.5
5 mononeuropathy 10.4
6 muscular atrophy 9.9
7 neurofibromatosis 9.9
8 rare tumor 9.9
9 neuritis 9.9
10 rasopathy 9.9
11 amyotrophy, monomelic 9.9
12 macrodactyly 9.9
13 carpal tunnel syndrome 9.9
14 sclerosing perineurioma 9.9 S100B MUC1
15 reticular perineurioma 9.9 S100B MUC1
16 intracranial cysts 9.9 S100B MUC1
17 aggressive digital papillary adenocarcinoma 9.9 S100B MUC1
18 meningeal melanocytoma 9.9 S100B MUC1
19 cerebral primitive neuroectodermal tumor 9.9 S100B MUC1
20 non-functioning pituitary adenoma 9.9 S100B MUC1
21 cutaneous leiomyosarcoma 9.9 S100B MUC1
22 leiomyosarcoma 9.9 S100B MUC1
23 sarcoma 9.9 S100B MUC1
24 syringocystadenoma papilliferum 9.9 S100B MUC1
25 chordoid meningioma 9.9 S100B MUC1
26 anaplastic ependymoma 9.9 S100B MUC1
27 epithelioid malignant peripheral nerve sheath tumor 9.9 S100B MUC1
28 malignant peripheral nerve sheath tumor 9.9 S100B MUC1
29 ossifying fibromyxoid tumor 9.9 S100B MUC1
30 polymorphous low-grade adenocarcinoma 9.9 S100B MUC1
31 eccrine porocarcinoma 9.9 S100B MUC1
32 chordoid glioma 9.9 S100B MUC1
33 dendritic cell tumor 9.9 S100B MUC1
34 fibrous meningioma 9.9 S100B MUC1
35 spiradenoma 9.9 S100B MUC1
36 optic nerve glioma 9.9 S100B MUC1
37 spindle cell rhabdomyosarcoma 9.9 S100B MUC1
38 ovarian small cell carcinoma 9.8 S100B MUC1
39 monophasic synovial sarcoma 9.8 S100B MUC1
40 clear cell meningioma 9.8 S100B MUC1
41 syringoma 9.8 S100B MUC1
42 cellular ependymoma 9.8 S100B MUC1
43 myxopapillary ependymoma 9.8 S100B MUC1
44 myxoid chondrosarcoma 9.8 S100B MUC1
45 chondrosarcoma 9.8 S100B MUC1
46 pleomorphic liposarcoma 9.8 S100B MUC1
47 papilloma of choroid plexus 9.8 S100B MUC1
48 hemangiopericytoma, malignant 9.8 S100B MUC1
49 myoepithelioma 9.8 S100B MUC1
50 pilomatrixoma 9.8 S100B MUC1

Graphical network of the top 20 diseases related to Localized Hypertrophic Neuropathy:



Diseases related to Localized Hypertrophic Neuropathy

Symptoms & Phenotypes for Localized Hypertrophic Neuropathy

Drugs & Therapeutics for Localized Hypertrophic Neuropathy

Search Clinical Trials , NIH Clinical Center for Localized Hypertrophic Neuropathy

Genetic Tests for Localized Hypertrophic Neuropathy

Anatomical Context for Localized Hypertrophic Neuropathy

MalaCards organs/tissues related to Localized Hypertrophic Neuropathy:

40
Pituitary

Publications for Localized Hypertrophic Neuropathy

Articles related to Localized Hypertrophic Neuropathy:

(show all 36)
# Title Authors PMID Year
1
Proptosis due to intraorbital space-occupying lesions in children. 61
32676791 2020
2
Localized Hypertrophic Neuropathy as a Neoplastic Manifestation of KRAS-Mediated RASopathy. 61
32388560 2020
3
Sciatic nerve hypertrophy with Klippel-Trenaunay syndrome: a case report. 61
26037196 2015
4
Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings. 61
22832864 2012
5
Localized hypertrophic neuropathy: a case report and review of the literature. 61
19216221 2009
6
Intraneural perineurioma: a systematic review with illustrative cases. 61
17824794 2007
7
Intraneural perineurioma in a child with Beckwith-Wiedemann syndrome. 61
15750909 2005
8
A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center. 61
15739553 2005
9
Radial nerve palsy owing to localized hypertrophic neuropathy (intraneural perineurioma) in early childhood. 61
15032391 2004
10
Intraosseous intraneural perineurioma: report of a case with morphological, immunohistochemical and FISH study. 61
14704619 2004
11
[Localized hypertrophic neuropathy (LHN) of the brachial plexus: diagnosis and presurgical evaluation with MRI]. 61
12149594 2002
12
Hypertrophic neuropathy of the facial nerve. 61
11269771 2001
13
[Localized hypertrophic neuropathy: differential diagnosis of intraneural perineurioma]. 61
10648999 2000
14
Hypertrophic inflammatory neuropathy involving bilateral brachial plexus. 61
10595765 1999
15
Localized hypertrophic neuropathy involving the inferior alveolar nerve. 61
9915404 1999
16
Localized hypertrophic neuropathy: magnetic resonance imaging findings and long-term follow-up. 61
9883854 1999
17
Resection and graft repair for localized hypertrophic neuropathy. 61
9657192 1998
18
Focal posterior interosseous neuropathy in the presence of hereditary motor and sensory neuropathy, type I. 61
8618563 1996
19
Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22. 61
7785653 1995
20
[A case of localized hypertrophic neuropathy in the sciatic nerve]. 61
7781213 1995
21
Localized hypertrophic neuropathy. 61
8035630 1994
22
Localized hypertrophic neuropathy (LHN). 61
1332008 1992
23
Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. 61
1497116 1992
24
Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy. 61
1320324 1992
25
The enigmatic perineurial cell and its participation in tumors and in tumorlike entities. 61
1755098 1991
26
Localized hypertrophic neuropathy: possible focal perineurial barrier defect. 61
2655369 1989
27
The immunohistochemical demonstration of early perineurial change in the development of localized hypertrophic neuropathy. 61
2847973 1988
28
Localized hypertrophic mononeuropathy involving the tibial nerve. 61
2847076 1988
29
Localized hypertrophic neuropathy--a rare and clinically almost unknown syndrome. 61
3791730 1986
30
Perineural cell tumor. Immunocytochemical and ultrastructural characterization. Relationship to other peripheral nerve tumors with a review of the literature. 61
3080843 1986
31
Localized hypertrophic neuropathy: a perineurialoma? 61
3995812 1985
32
Localized hypertrophic neuropathy--a rare, clinically almost unknown syndrome. 61
6094068 1984
33
Perineurioma (localized hypertrophic neuropathy). 61
6329127 1984
34
Perineurioma as the cause of localized hypertrophic neuropathy. 61
6775221 1980
35
Letter: Localized hypertrophic neuropathy, intraneural tumour, or chronic nerve entrapment? 61
47973 1975
36
Macrodactyly and localized hypertrophic neuropathy. 61
4367276 1974

Variations for Localized Hypertrophic Neuropathy

Expression for Localized Hypertrophic Neuropathy

Search GEO for disease gene expression data for Localized Hypertrophic Neuropathy.

Pathways for Localized Hypertrophic Neuropathy

GO Terms for Localized Hypertrophic Neuropathy

Sources for Localized Hypertrophic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
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39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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