MCID: LCL011
MIFTS: 15

Localized Hypertrophic Neuropathy

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Localized Hypertrophic Neuropathy

MalaCards integrated aliases for Localized Hypertrophic Neuropathy:

Name: Localized Hypertrophic Neuropathy 54
Onion Whorl Disease 54

Classifications:



Summaries for Localized Hypertrophic Neuropathy

NIH Rare Diseases : 54 Localized hypertrophic neuropathy is a nerve condition in which nerve cells increase in number and form bundles that look like onion bulbs.  This condition affects one nerve, usually in an arm or leg.  The symptoms of this condition include muscle weakness, numbness, and decreased reflexes in the affected limb.  Symptoms slowly get worse over time.  The cause of this condition is unknown, but some researchers believe it might be a type of tumor, while others believe it might be an unusual reaction to injury.

MalaCards based summary : Localized Hypertrophic Neuropathy, also known as onion whorl disease, is related to perineurioma and intraneural perineurioma. An important gene associated with Localized Hypertrophic Neuropathy is MUC1 (Mucin 1, Cell Surface Associated).

Related Diseases for Localized Hypertrophic Neuropathy

Diseases related to Localized Hypertrophic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 perineurioma 30.1 MUC1 S100B
2 intraneural perineurioma 29.5 MUC1 S100B
3 neurofibroma 29.4 MUC1 S100B
4 neuropathy 10.5
5 sclerosing perineurioma 9.9 MUC1 S100B
6 intracranial cysts 9.9 MUC1 S100B
7 reticular perineurioma 9.9 MUC1 S100B
8 non-functioning pituitary adenoma 9.9 MUC1 S100B
9 functioning pituitary adenoma 9.9 MUC1 S100B
10 syringocystadenoma papilliferum 9.9 MUC1 S100B
11 epithelioid malignant peripheral nerve sheath tumor 9.9 MUC1 S100B
12 malignant peripheral nerve sheath tumor 9.9 MUC1 S100B
13 ossifying fibromyxoid tumor 9.9 MUC1 S100B
14 fibrous meningioma 9.9 MUC1 S100B
15 chordoid meningioma 9.9 MUC1 S100B
16 eccrine porocarcinoma 9.9 MUC1 S100B
17 spindle cell rhabdomyosarcoma 9.9 MUC1 S100B
18 aggressive digital papillary adenocarcinoma 9.9 MUC1 S100B
19 myxopapillary ependymoma 9.9 MUC1 S100B
20 ependymoma 9.9 MUC1 S100B
21 monophasic synovial sarcoma 9.9 MUC1 S100B
22 chordoid glioma 9.9 MUC1 S100B
23 spiradenoma 9.9 MUC1 S100B
24 syringoma 9.9 MUC1 S100B
25 pleomorphic liposarcoma 9.9 MUC1 S100B
26 anaplastic ependymoma 9.9 MUC1 S100B
27 papilloma of choroid plexus 9.9 MUC1 S100B
28 spindle cell sarcoma 9.9 MUC1 S100B
29 meningeal melanocytoma 9.8 MUC1 S100B
30 dendritic cell tumor 9.8 MUC1 S100B
31 macrodactyly 9.8
32 cerebral primitive neuroectodermal tumor 9.8 MUC1 S100B
33 polymorphous low-grade adenocarcinoma 9.8 MUC1 S100B
34 hemangiopericytoma, malignant 9.8 MUC1 S100B
35 malignant fibroxanthoma 9.8 MUC1 S100B
36 optic nerve glioma 9.8 MUC1 S100B
37 meningioma, radiation-induced 9.8 MUC1 S100B
38 pilomatrixoma 9.8 MUC1 S100B
39 hemangioblastoma 9.7 MUC1 S100B
40 pleomorphic adenoma 9.7 MUC1 S100B
41 chordoma 9.6 MUC1 S100B
42 adenoid cystic carcinoma 9.5 MUC1 S100B

Graphical network of the top 20 diseases related to Localized Hypertrophic Neuropathy:



Diseases related to Localized Hypertrophic Neuropathy

Symptoms & Phenotypes for Localized Hypertrophic Neuropathy

Drugs & Therapeutics for Localized Hypertrophic Neuropathy

Search Clinical Trials , NIH Clinical Center for Localized Hypertrophic Neuropathy

Genetic Tests for Localized Hypertrophic Neuropathy

Anatomical Context for Localized Hypertrophic Neuropathy

Publications for Localized Hypertrophic Neuropathy

Articles related to Localized Hypertrophic Neuropathy:

(show all 19)
# Title Authors Year
1
Localized hypertrophic neuropathy of the sciatic nerve in children: MRI findings. ( 22832864 )
2012
2
Localized hypertrophic neuropathy: a case report and review of the literature. ( 19216221 )
2009
3
Radial nerve palsy owing to localized hypertrophic neuropathy (intraneural perineurioma) in early childhood. ( 15032391 )
2004
4
Localized hypertrophic neuropathy: magnetic resonance imaging findings and long-term follow-up. ( 9883854 )
1999
5
Localized hypertrophic neuropathy involving the inferior alveolar nerve. ( 9915404 )
1999
6
Resection and graft repair for localized hypertrophic neuropathy. ( 9657192 )
1998
7
Localized hypertrophic neuropathy. ( 8035630 )
1994
8
Perineurioma: an uncommon soft tissue neoplasm distinct from localized hypertrophic neuropathy and neurofibroma. ( 1497116 )
1992
9
Localized hypertrophic neuropathy (LHN). ( 1332008 )
1992
10
Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy. ( 1320324 )
1992
11
Localized hypertrophic neuropathy: possible focal perineurial barrier defect. ( 2655369 )
1989
12
The immunohistochemical demonstration of early perineurial change in the development of localized hypertrophic neuropathy. ( 2847973 )
1988
13
Localized hypertrophic neuropathy--a rare and clinically almost unknown syndrome. ( 3791730 )
1986
14
Localized hypertrophic neuropathy: a perineurialoma? ( 3995812 )
1985
15
Localized hypertrophic neuropathy--a rare, clinically almost unknown syndrome. ( 6094068 )
1984
16
Perineurioma (localized hypertrophic neuropathy). ( 6329127 )
1984
17
Perineurioma as the cause of localized hypertrophic neuropathy. ( 6775221 )
1980
18
Letter: Localized hypertrophic neuropathy, intraneural tumour, or chronic nerve entrapment? ( 47973 )
1975
19
Macrodactyly and localized hypertrophic neuropathy. ( 4367276 )
1974

Variations for Localized Hypertrophic Neuropathy

Expression for Localized Hypertrophic Neuropathy

Search GEO for disease gene expression data for Localized Hypertrophic Neuropathy.

Pathways for Localized Hypertrophic Neuropathy

GO Terms for Localized Hypertrophic Neuropathy

Sources for Localized Hypertrophic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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