MCID: LCL022
MIFTS: 36

Localized Lipodystrophy

Categories: Rare diseases, Skin diseases, Endocrine diseases

Aliases & Classifications for Localized Lipodystrophy

MalaCards integrated aliases for Localized Lipodystrophy:

Name: Localized Lipodystrophy 53
Pressure-Induced Localized Lipoatrophy 53 59
Drug-Induced Localized Lipodystrophy 53 59
Idiopathic Localized Lipodystrophy 53 59
Centrifugal Lipodystrophy 53 59
Semicircular Lipoatrophy 59 73
Lipodystrophia Centrifugalis Abdominalis Infantilis 59
Panniculitis and Localized Lipodystrophy 53
Lipoatrophy Caused by Injected Drug 59
Lipoatrophia Semicircularis 59

Classifications:



Summaries for Localized Lipodystrophy

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 79088Disease definitionLocalised lipodystrophies are characterised by loss of subcutaneous tissue from small regions of the body.EpidemiologyThe term covers a heterogeneous group of conditions for which the prevalence varies according to the cause.Clinical descriptionDercum's disease (adiposis dolorosa) is a rare condition characterised by the progressive appearance of painful fatty deposits, generally in menopausal women presenting with obesity. Sclerodermiform lipodystrophy of the abdomen and thighs may be caused by a graft versus host reaction following a bone marrow allograft for a haematological disorder.EtiologyLipodystrophies caused by a poor injection technique when administering insulin are frequent. Localised lipodystrophy may also be associated with an iatrogenic cause linked to injection of other substances such as steroids, somatostatin, glatiramer acetate (administered for multiple sclerosis) or exogenous material. They are sometimes triggered by pressure or by panniculitis, such as nodular non-suppurative panniculitis (Weber-Christian syndrome).Differential diagnosisDifferential diagnoses may include scleroderma, idiopathic dermal atrophy, idiopathic atrophoderma of Pasini and Pierini, and Gowers panatrophy.Genetic counselingIdiopathic causes are not rare.Management and treatmentTreatment should revolve around elimination of the cause whenever possible: modification of the injection technique for insulin therapy, plastic surgery if necessary, or immunosuppressive therapy in case of a graft versus host reaction. Localised lipodystrophy associated with insulin therapy usually resolves in a few weeks after changing the site of injection and modification of the length of the needle.PrognosisThe prognosis depends on the cause but is more severe in case of panniculitis or a graft versus host reaction.Visit the Orphanet disease page for more resources.

MalaCards based summary : Localized Lipodystrophy, also known as pressure-induced localized lipoatrophy, is related to myositis and panniculitis-induced localized lipodystrophy. An important gene associated with Localized Lipodystrophy is DMD (Dystrophin), and among its related pathways/superpathways is Cardiac conduction. Affiliated tissues include skin, bone and bone marrow, and related phenotypes are lipoatrophy and reduced subcutaneous adipose tissue

Wikipedia : 76 Localized lipodystrophy is a skin condition characterized by the loss subcutaneous fat localized to... more...

Related Diseases for Localized Lipodystrophy

Graphical network of the top 20 diseases related to Localized Lipodystrophy:



Diseases related to Localized Lipodystrophy

Symptoms & Phenotypes for Localized Lipodystrophy

Human phenotypes related to Localized Lipodystrophy:

59 32 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lipoatrophy 59 32 hallmark (90%) Obligate (100%),Obligate (100%),Obligate (100%),Obligate (100%) HP:0100578
2 reduced subcutaneous adipose tissue 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%),Very frequent (99-80%),Very frequent (99-80%) HP:0003758
3 absence of subcutaneous fat 59 32 frequent (33%) Frequent (79-30%),Frequent (79-30%),Frequent (79-30%),Frequent (79-30%) HP:0007485
4 abnormality of the thorax 59 32 occasional (7.5%) Occasional (29-5%) HP:0000765
5 lymphadenitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002840
6 erythema 59 32 occasional (7.5%) Occasional (29-5%),Occasional (29-5%),Frequent (79-30%),Occasional (29-5%) HP:0010783
7 inflammatory abnormality of the skin 59 32 occasional (7.5%) Occasional (29-5%),Frequent (79-30%),Occasional (29-5%) HP:0011123
8 scaling skin 59 32 occasional (7.5%) Occasional (29-5%),Very rare (<4-1%) HP:0040189
9 alopecia 59 32 very rare (1%) Very rare (<4-1%) HP:0001596
10 lack of facial subcutaneous fat 59 32 very rare (1%) Very rare (<4-1%) HP:0005320
11 hyperpigmentation of the skin 59 32 occasional (7.5%) Occasional (29-5%),Occasional (29-5%) HP:0000953
12 hypopigmentation of the skin 59 32 occasional (7.5%) Occasional (29-5%),Occasional (29-5%) HP:0001010
13 regional abnormality of skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0011356
14 skin nodule 59 32 frequent (33%) Frequent (79-30%) HP:0200036
15 pruritus 59 32 occasional (7.5%) Occasional (29-5%) HP:0000989
16 morphea 59 32 very rare (1%) Very rare (<4-1%) HP:0012344
17 scleroderma 59 32 very rare (1%) Very rare (<4-1%) HP:0100324
18 abnormal subcutaneous fat tissue distribution 32 hallmark (90%) HP:0007552

Drugs & Therapeutics for Localized Lipodystrophy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Candela 1064nm:Nd:YAG Laser for Skin Tightening Completed NCT00585715 Not Applicable

Search NIH Clinical Center for Localized Lipodystrophy

Genetic Tests for Localized Lipodystrophy

Anatomical Context for Localized Lipodystrophy

MalaCards organs/tissues related to Localized Lipodystrophy:

41
Skin, Bone, Bone Marrow

Publications for Localized Lipodystrophy

Articles related to Localized Lipodystrophy:

(show all 12)
# Title Authors Year
1
Localized Lipodystrophy following Single Dose Intramuscular Gentamycin Injection. ( 28979879 )
2017
2
Centrifugal lipodystrophy of the scalp manifesting as centrifugal lipodystrophic alopecia. ( 29266423 )
2017
3
Tissue expander reconstruction of centrifugal lipodystrophy of the abdominal wall. ( 20811202 )
2010
4
Myositis associated with localized lipodystrophy: an unrecognized condition? ( 19541581 )
2009
5
Centrifugal lipodystrophy of the scalp presenting with an arch-form alopecia: a 10-year follow-up observation. ( 19712277 )
2009
6
Centrifugal lipodystrophy mimicking 'lipodystrophia centrifugalis abdominalis infantilis' in a Caucasian adult. ( 17894715 )
2007
7
Localized lipodystrophy in a child. ( 12220289 )
2002
8
Centrifugal lipodystrophy presenting with serpiginous erythema and alopecia. ( 12080947 )
2002
9
Centrifugal lipodystrophy of the face mimicking progressive lipodystrophy. ( 1419763 )
1992
10
Localized lipodystrophy with panniculitis: light and electron microscopic studies. ( 2613949 )
1989
11
Partial (localized) lipodystrophy. Report of a case with muscle and skin abnormalities. ( 3973119 )
1985
12
Centrifugal lipodystrophy. ( 6691914 )
1984

Variations for Localized Lipodystrophy

Expression for Localized Lipodystrophy

Search GEO for disease gene expression data for Localized Lipodystrophy.

Pathways for Localized Lipodystrophy

GO Terms for Localized Lipodystrophy

Cellular components related to Localized Lipodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lamellipodium GO:0030027 8.96 DMD DYSF
2 sarcolemma GO:0042383 8.62 DMD DYSF

Sources for Localized Lipodystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....