MCID: LCL022
MIFTS: 31

Localized Lipodystrophy

Categories: Endocrine diseases, Metabolic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Localized Lipodystrophy

MalaCards integrated aliases for Localized Lipodystrophy:

Name: Localized Lipodystrophy 20 58
Pressure-Induced Localized Lipoatrophy 20 58
Drug-Induced Localized Lipodystrophy 20 58
Idiopathic Localized Lipodystrophy 20 58
Centrifugal Lipodystrophy 20 58
Semicircular Lipoatrophy 58 70
Lipodystrophia Centrifugalis Abdominalis Infantilis 58
Panniculitis and Localized Lipodystrophy 20
Lipoatrophy Caused by Injected Drug 58
Lipoatrophia Semicircularis 58

Characteristics:

Orphanet epidemiological data:

58
localized lipodystrophy
Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare skin diseases
Rare endocrine diseases


Summaries for Localized Lipodystrophy

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 79088 Definition A rare group of acquired lipodystrophies that are characterized by loss of subcutaneous tissue from generally small regions of the body, either single or multiple areas, and are not typically associated with metabolic complications. Some cases may involve lipohypertrophy (insulin). This group includes pressure-induced localized lipoatrophy, drug-induced localized lipodystrophy, panniculitis- induced localized lipodystrophy, centrifugal lipodystrophy, and idiopathic localized lipodystrophy. Epidemiology The term covers a heterogeneous group of conditions for which the prevalence varies according to the cause. Clinical description Localized lipohypertrophy involves small body areas, manifesting as either a soft bump or a depression in the soft tissue, and are not usually accompanied by a metabolic syndrome. They are most frequently observed in association with repeated mechanical microtraumatism (pressure induced localized lipoatrophy) such as drug injection, but may also be seen as the sequelae of an inflammation (panniculitis-induced localized lipodystrophy). Drug-induced localized lipodystrophy is often observed in diabetes associated with steroid or antiretroviral treatment leading to possible android obesity, and sometimes a lipoatrophy of Bichat balls under antiretroviral drugs. Centrifugal lipodystrophy is characterized by fat loss spread in a centrifugal pattern from abdomen and groin area and is associated with peripheral panniculitis. It begins in infancy, stops spreading between the ages of 3 and 8 and then in most cases, resolves by itself. Panniculitis-induced localized lipodystrophy is characterized by an initial development of panniculitis followed by localized fat loss when these lesions heal. The disease is associated with serum ANA and anti dsDNA antibodies, patients may also have concurrent autoimmune diseases. Localized lipoatrophy is not painful but can induce discomfort, especially when they are localized in a support zone such as the bottom, or dressing difficulties or aesthetic prejudice. Etiology Localized lipodystrophy is generally iatrogenic and secondary to medication injections (somatostatin analogs, pegvisomant, insulin), vaccines or repetitive pressure trauma. In addition certain medications can induce localized lipodystrophy such as steroids or antiretroviral treatment, or it can be triggered by panniculitis (such as nodular non-suppurative panniculitis, Weber-Christian syndrome). The etiology for idiopathic localized lipodystrophy and centrifugal localized lipodystrophy remains unknown. Differential diagnosis Differential diagnoses may include scleroderma, idiopathic dermal atrophy, idiopathic atrophoderma of Pasini and Pierini, and Gowers panatrophy. Antenatal diagnosis Not applicable. Genetic counseling Not applicable. Management and treatment Treatment should revolve around elimination of the cause whenever possible: modification of the injection technique or plastic surgery if necessary. Localized lipodystrophy associated with insulin therapy usually resolves in a few weeks after changing the site of injection and modification of the length of the needle. Prognosis The prognosis depends on the cause but is more severe in case of panniculitis.

MalaCards based summary : Localized Lipodystrophy, also known as pressure-induced localized lipoatrophy, is related to myositis and panniculitis-induced localized lipodystrophy. An important gene associated with Localized Lipodystrophy is DMD (Dystrophin), and among its related pathways/superpathways is Cardiac conduction. Affiliated tissues include skin, and related phenotypes are lipoatrophy and reduced subcutaneous adipose tissue

Wikipedia : 73 Localized lipodystrophy is a skin condition characterized by the loss subcutaneous fat localized to... more...

Related Diseases for Localized Lipodystrophy

Diseases in the Primary Lipodystrophy family:

Localized Lipodystrophy Acquired Lipodystrophy

Diseases related to Localized Lipodystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 myositis 29.3 DYSF DMD
2 panniculitis-induced localized lipodystrophy 11.1
3 localized scleroderma 10.6
4 kawasaki disease 10.5
5 immunoglobulin alpha deficiency 10.5
6 skin disease 10.5
7 growth hormone deficiency 10.5
8 encephalopathy 10.5
9 somatoform disorder 10.2
10 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.2
11 alopecia 10.2
12 systemic lupus erythematosus 10.0
13 crest syndrome 10.0
14 collagen disease 10.0
15 lupus erythematosus 10.0
16 raynaud phenomenon 10.0
17 muscular dystrophy, limb-girdle, autosomal recessive 7 9.9 DYSF DMD
18 muscular dystrophy 9.9 DYSF DMD
19 autosomal recessive limb-girdle muscular dystrophy 9.9 DYSF DMD
20 autosomal recessive limb-girdle muscular dystrophy type 2c 9.9 DYSF DMD
21 autosomal recessive limb-girdle muscular dystrophy type 2f 9.9 DYSF DMD
22 muscular dystrophy, limb-girdle, autosomal recessive 6 9.8 DYSF DMD
23 autosomal recessive limb-girdle muscular dystrophy type 2a 9.8 DYSF DMD
24 cardiomyopathy, dilated, 3b 9.8 DYSF DMD
25 autoimmune disease 9.8
26 congenital generalized lipodystrophy 9.8
27 panniculitis 9.8
28 myopathy 9.8
29 connective tissue disease 9.8
30 myopathy, myofibrillar, 3 9.8 DYSF DMD
31 autosomal recessive limb-girdle muscular dystrophy type 2d 9.8 DYSF DMD
32 muscular dystrophy, congenital merosin-deficient, 1a 9.8 DYSF DMD
33 autosomal recessive limb-girdle muscular dystrophy type 2b 9.8 DYSF DMD
34 tibial muscular dystrophy 9.8 DYSF DMD
35 nonaka myopathy 9.8 DYSF DMD
36 emery-dreifuss muscular dystrophy 2, autosomal dominant 9.8 DYSF DMD
37 emery-dreifuss muscular dystrophy 9.8 DYSF DMD
38 muscular dystrophy, becker type 9.8 DYSF DMD
39 batten-turner congenital myopathy 9.8 DYSF DMD
40 isolated elevated serum creatine phosphokinase levels 9.8 DYSF DMD
41 rigid spine muscular dystrophy 1 9.8 DYSF DMD
42 ullrich congenital muscular dystrophy 1 9.8 DYSF DMD
43 bethlem myopathy 1 9.8 DYSF DMD
44 muscular dystrophy-dystroglycanopathy 9.8 DYSF DMD
45 miyoshi muscular dystrophy 9.8 DYSF DMD
46 centronuclear myopathy 9.8 DYSF DMD
47 congenital fiber-type disproportion 9.8 DYSF DMD
48 x-linked recessive disease 9.8 DYSF DMD
49 muscle tissue disease 9.8 DYSF DMD
50 myofibrillar myopathy 9.7 DYSF DMD

Graphical network of the top 20 diseases related to Localized Lipodystrophy:



Diseases related to Localized Lipodystrophy

Symptoms & Phenotypes for Localized Lipodystrophy

Human phenotypes related to Localized Lipodystrophy:

58 31 (show all 19)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lipoatrophy 58 31 hallmark (90%) Obligate (100%),Obligate (100%),Obligate (100%),Obligate (100%) HP:0100578
2 reduced subcutaneous adipose tissue 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%),Very frequent (99-80%),Very frequent (99-80%) HP:0003758
3 regional abnormality of skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0011356
4 abnormal subcutaneous fat tissue distribution 31 hallmark (90%) HP:0007552
5 erythema 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%),Occasional (29-5%),Frequent (79-30%) HP:0010783
6 skin nodule 58 31 frequent (33%) Frequent (79-30%) HP:0200036
7 inflammatory abnormality of the skin 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%),Frequent (79-30%) HP:0011123
8 absence of subcutaneous fat 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%),Frequent (79-30%),Frequent (79-30%) HP:0007485
9 pruritus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000989
10 hypopigmentation of the skin 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%) HP:0001010
11 hyperpigmentation of the skin 58 31 occasional (7.5%) Occasional (29-5%),Occasional (29-5%) HP:0000953
12 scaling skin 58 31 occasional (7.5%) Very rare (<4-1%),Occasional (29-5%) HP:0040189
13 lymphadenitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002840
14 abnormal thorax morphology 31 occasional (7.5%) HP:0000765
15 alopecia 58 31 very rare (1%) Very rare (<4-1%) HP:0001596
16 scleroderma 58 31 very rare (1%) Very rare (<4-1%) HP:0100324
17 morphea 58 31 very rare (1%) Very rare (<4-1%) HP:0012344
18 lack of facial subcutaneous fat 58 31 very rare (1%) Very rare (<4-1%) HP:0005320
19 abnormality of the thorax 58 Occasional (29-5%)

Drugs & Therapeutics for Localized Lipodystrophy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Candela 1064nm:Nd:YAG Laser for Skin Tightening Completed NCT00585715

Search NIH Clinical Center for Localized Lipodystrophy

Genetic Tests for Localized Lipodystrophy

Anatomical Context for Localized Lipodystrophy

MalaCards organs/tissues related to Localized Lipodystrophy:

40
Skin

Publications for Localized Lipodystrophy

Articles related to Localized Lipodystrophy:

(show all 39)
# Title Authors PMID Year
1
Localized Lipodystrophy following Single Dose Intramuscular Gentamycin Injection. 61
28979879 2017
2
[Semicircular lipoatrophy: Three clinical cases]. 61
27436818 2017
3
Lipodystrophy Syndromes. 61
27823605 2016
4
[Occupational semicircular lipoatrophy associated with serum adipokine abnormalities]. 61
25794769 2015
5
Reticular infantile hemangiomas with minimal or arrested growth associated with lipoatrophy. 61
25766364 2015
6
Power-Frequency Magnetic Field Inhibits Adipogenic Differentiation in Human ADSC. 61
26625130 2015
7
Semicircular lipoatrophy: an electrostatic hypothesis. 61
25721213 2015
8
Electrolyte and Haemogram changes post large volume liposuction comparing two different tumescent solutions. 61
25593425 2014
9
Case of semicircular lipoatrophy: relation between its characteristic distribution and anatomical muscle structure. 61
25039249 2014
10
Diphlorethohydroxycarmalol of Ishige okamurae and Caffeine Modified the Expression of Extracellular Fibrillars during Adipogenesis of Mouse Subcutaneous Adipose Derived Stem Cell. 61
25949143 2013
11
[False amyotrophy in the forearms due to semicircular lipoatrophy]. 61
23568689 2013
12
Case-control study of semicircular lipoatrophy, a new occupational disease in office workers. 61
23648474 2013
13
[Semicircular lipoatrophy: are there effective alternative measures?]. 61
22483408 2012
14
[Semicircular lipoatrophy. The case of a very tall worker]. 61
22948432 2012
15
[Semicircular lipoatrophy in office workers]. 61
19427654 2010
16
Myositis associated with localized lipodystrophy: an unrecognized condition? 61
19541581 2009
17
[Pressure-induced lipoatrophia semicircularis]. 61
18501172 2008
18
[Semicircular lipoatrophy: a new occupational disease]. 61
18261447 2008
19
What is your diagnosis? Semicircular lipoatrophy. 61
18246876 2007
20
[Electromagnetic lipolysis and semicircular lipoatrophy of the thighs]. 61
16885849 2006
21
Annular lipoatrophy of the ankles. 61
16427990 2006
22
A new case of semicircular lipoatrophy associated with repeated external microtraumas and review of the literature. 61
15987293 2005
23
Magnetic resonance imaging of semicircular lipoatrophy. 61
15539902 2004
24
Annular, semicircular lipoatrophy of the thighs associated with incomplete "CREST" syndrome: Raynaud's, telangiectasias, and esophageal dysmotility. 61
17041445 2003
25
Semicircular lipoatrophy in a child with systemic lupus erythematosus after subcutaneous injections with methotrexate. 61
12383102 2002
26
Localized lipodystrophy in a child. 61
12220289 2002
27
Semicircular lipoatrophy: 18 cases in the same company. 61
10703634 2000
28
New indications in the approach to the pendulous abdomen. 61
10441716 1999
29
[Impressions on the thighs; semicircular lipoatrophy]. 61
9646613 1998
30
Semicircular lipoatrophy after intragluteal injection of benzathine penicillin. 61
8757581 1996
31
Semicircular lipoatrophy. 61
1458656 1992
32
Semicircular lipoatrophy--a pressure-induced lipoatrophy? 61
2279347 1990
33
Localized lipodystrophy with panniculitis: light and electron microscopic studies. 61
2613949 1989
34
Annular and semicircular lipoatrophies. Report of three cases and review of the literature. 61
2645320 1989
35
Submental-submandibular suction lipectomy: indications and surgical technique. 61
2645554 1989
36
[The 1st case of semicircular lipoatrophy in childhood]. 61
3451074 1987
37
Partial (localized) lipodystrophy. Report of a case with muscle and skin abnormalities. 61
3973119 1985
38
Semicircular lipoatrophy. 61
7295573 1981
39
[Lipoatrophia semicircularis in the male. Coincidence of arterial variations and micro-traumas as a possible disease cause]. 61
659107 1978

Variations for Localized Lipodystrophy

Expression for Localized Lipodystrophy

Search GEO for disease gene expression data for Localized Lipodystrophy.

Pathways for Localized Lipodystrophy

GO Terms for Localized Lipodystrophy

Cellular components related to Localized Lipodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sarcolemma GO:0042383 8.62 DYSF DMD

Sources for Localized Lipodystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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