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MCID: LCL004
MIFTS: 29

Localized Osteosarcoma

Categories: Cancer diseases, Bone diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Localized Osteosarcoma

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MalaCards integrated aliases for Localized Osteosarcoma:

Name: Localized Osteosarcoma 12 15 73
Localized Osteogenic Sarcoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3356
NCIt 50 C7780
UMLS 73 C0278511
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Summaries for Localized Osteosarcoma

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MalaCards based summary : Localized Osteosarcoma, also known as localized osteogenic sarcoma, is related to necrotizing sialometaplasia and blastic plasmacytoid dendritic cell. An important gene associated with Localized Osteosarcoma is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways is Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. The drugs Cisplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver.

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Related Diseases for Localized Osteosarcoma

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Diseases related to Localized Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 necrotizing sialometaplasia 9.9 CDKN2A TIA1
2 blastic plasmacytoid dendritic cell 9.8 CDKN2A CLEC4C
3 body mass index quantitative trait locus 1 9.6
4 sarcoma 9.6
5 b-cell lymphomas 9.5 CDKN2A TIA1
6 integumentary system cancer 9.4 CDKN2A GLI2

Graphical network of the top 20 diseases related to Localized Osteosarcoma:



Diseases related to Localized Osteosarcoma
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Symptoms & Phenotypes for Localized Osteosarcoma

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Drugs & Therapeutics for Localized Osteosarcoma

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Drugs for Localized Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
2
Doxorubicin Approved, Investigational Phase 3,Phase 2,Not Applicable 23214-92-8 31703
3
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
4
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1,Not Applicable 3778-73-2 3690
6
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 51-75-2 4033
7
Methotrexate Approved Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Peginterferon alfa-2b Approved Phase 3 99210-65-8, 215647-85-1
10
Zoledronic acid Approved Phase 3 118072-93-8 68740
11
Cyproheptadine Approved Phase 3 129-03-3 2913
12
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Not Applicable 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Not Applicable 58-05-9 143 6006
15
Doxil Approved June 1999 Phase 3,Phase 2,Not Applicable 31703
16 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
17 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable
18 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
19 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable
20 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
21 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
22 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
23 Liver Extracts Phase 3,Phase 1,Not Applicable
24 Antiviral Agents Phase 3,Phase 2
25 Interferon-alpha Phase 3,Phase 2
26 interferons Phase 3,Phase 2
27 Adjuvants, Immunologic Phase 3,Phase 2
28 Antibiotics, Antitubercular Phase 3,Phase 2,Not Applicable
29 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
30 Antimetabolites Phase 3,Phase 2,Not Applicable
31 Antimetabolites, Antineoplastic Phase 3,Phase 2,Not Applicable
32 Antimitotic Agents Phase 3,Phase 2
33 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
34 Dermatologic Agents Phase 3,Phase 2,Not Applicable
35 Etoposide phosphate Phase 3,Phase 2,Phase 1
36 Folic Acid Antagonists Phase 3,Phase 2,Not Applicable
37
Isophosphamide mustard Phase 3,Phase 2,Phase 1,Not Applicable 0
38 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Not Applicable
39 Protective Agents Phase 3,Phase 2,Not Applicable
40 razoxane Phase 3,Phase 2
41 Vitamin B Complex Phase 3,Phase 2,Not Applicable
42 Antidotes Phase 3,Phase 2,Not Applicable
43 Antioxidants Phase 3
44 Antitubercular Agents Phase 3
45 Chelating Agents Phase 3,Not Applicable
46 sodium thiosulfate Phase 3
47 Adjuvants, Anesthesia Phase 3
48 Analgesics Phase 3,Phase 2
49 Analgesics, Opioid Phase 3
50 Anesthetics Phase 3

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
2 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
3 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Active, not recruiting NCT00134030 Phase 3 Cisplatin;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Methotrexate
6 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3 cisplatin;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate;zoledronic acid
7 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
8 Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma Unknown status NCT00026416 Phase 2 thalidomide
9 A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung Completed NCT00752206 Phase 2 Saracatinib;Placebo
10 Samarium Sm 153 and Stem Cell Transplant Followed By Radiation Therapy Patients With Osteosarcoma Completed NCT00245011 Phase 2 ifosfamide
11 Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
12 Sorafenib and Ifosfamide in Treating Patients With High-Grade Soft Tissue Sarcoma or Bone Sarcoma That Can Be Removed by Surgery Terminated NCT00880542 Phase 2 sorafenib;Ifosfamide
13 Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma Terminated NCT00019864 Phase 2 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;methotrexate
14 Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor Completed NCT00161187 Phase 1
15 High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer Completed NCT00002854 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;mesna;paclitaxel
16 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733 Not Applicable cyclophosphamide
17 Combination Chemotherapy in Treating Patients Undergoing Surgery for Newly Diagnosed High-Grade Osteosarcoma Completed NCT00645632 Not Applicable cisplatin;doxorubicin hydrochloride;ifosfamide;methotrexate
18 Studying DNA in Tumor Tissue Samples From Patients With Localized or Metastatic Osteosarcoma Completed NCT01062438
19 Biomarker Expression in Tissue Samples From Patients With Bone Sarcomas Completed NCT01807052
20 Study of Blood Samples From Patients With Osteosarcoma Completed NCT00954473
21 Biomarkers in Predicting Response to Chemotherapy in Samples From Young Patients With Osteosarcoma Completed NCT01374672
22 Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer Completed NCT00002485
23 Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin Lymphoma Completed NCT00040911 Not Applicable
24 PET Scan Combined With CT Scan in Evaluating Treatment Response in Patients Undergoing Treatment for Bone Cancer or Soft Tissue Sarcoma Completed NCT00335751 Not Applicable
25 Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma Completed NCT00003793
26 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
27 DNA Biomarkers in Tissue Samples From Patients With Osteosarcoma Active, not recruiting NCT01190943
28 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine
29 Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection Withdrawn NCT00378781 Not Applicable Heparin;Minocycline-EDTA

Search NIH Clinical Center for Localized Osteosarcoma

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Genetic Tests for Localized Osteosarcoma

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Anatomical Context for Localized Osteosarcoma

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MalaCards organs/tissues related to Localized Osteosarcoma:

41
Bone, Lung, Liver
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Publications for Localized Osteosarcoma

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Articles related to Localized Osteosarcoma:

(show all 28)
# Title Authors Year
1
Tumoral immune-infiltrate (IF), PD-L1 expression and role of CD8/TIA-1 lymphocytes in localized osteosarcoma patients treated within protocol ISG-OS1. ( 29340095 )
2017
2
P16 expression as a prognostic and predictive marker in high grade localized osteosarcoma of the extremities: An analysis of 357 cases. ( 27544803 )
2016
3
Developing a prognostic model for patients with localized osteosarcoma treated with uniform chemotherapy protocol without high dose methotrexate: A single-center experience of 237 patients. ( 26381138 )
2015
4
Risk-Based Therapy for Localized Osteosarcoma. ( 26501936 )
2015
5
Characterization of localized osteosarcoma of the extremity in children, adolescents, and young adults from a single institution in South Texas. ( 24487915 )
2014
6
Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: A systemic review and meta-analysis of cohort studies. ( 25231396 )
2014
7
Reply to the Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 25099264 )
2014
8
Letter to the editor: Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 25106799 )
2014
9
Surgical resection of relapse may improve postrelapse survival of patients with localized osteosarcoma. ( 22972657 )
2013
10
Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study. ( 24178953 )
2013
11
Meta-analysis of limb salvage versus amputation for treating high-grade and localized osteosarcoma in patients with pathological fracture. ( 23226744 )
2012
12
Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. ( 21480474 )
2011
13
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial. ( 21656756 )
2011
14
Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. ( 21563300 )
2011
15
Intensive induction chemotherapy without methotrexate in adult patients with localized osteosarcoma: results of the Institut Gustave-Roussy phase II trial. ( 21151406 )
2010
16
Pharmacokinetic individualization of high-dose methotrexate chemotherapy for the treatment of localized osteosarcoma. ( 20566424 )
2010
17
How can survival be improved in localized osteosarcoma? ( 20735316 )
2010
18
Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma. ( 19021220 )
2009
19
Prognostic effect of pathologic fracture in localized osteosarcoma: a cohort/case controlled study at a single institute. ( 19294672 )
2009
20
Tumor necrosis rate adjusted by tumor volume change is a better predictor of survival of localized osteosarcoma patients. ( 18163171 )
2008
21
Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. ( 18270971 )
2008
22
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. ( 16246977 )
2005
23
The feasibility of neoadjuvant high-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with nonmetastatic high grade localized osteosarcoma: results of a phase II study. ( 15999369 )
2005
24
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. ( 11596036 )
2001
25
Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities. ( 11516856 )
2001
26
Reproductive functions in female patients treated with adjuvant and neoadjuvant chemotherapy for localized osteosarcoma of the extremity. ( 11064353 )
2000
27
[Neoadjuvant therapy for localized osteosarcoma of extremities. Results from the Cooperative osteosarcoma study group COSS of 925 patients]. ( 10472560 )
1999
28
The treatment of localized osteosarcoma of the extremities: the Italian experience. Studies of the National Research Council. ( 1622856 )
1992
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Variations for Localized Osteosarcoma

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Expression for Localized Osteosarcoma

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Search GEO for disease gene expression data for Localized Osteosarcoma.
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Pathways for Localized Osteosarcoma

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Pathways related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling 65
Show member pathways
 10.8 FRZB GLI2
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GO Terms for Localized Osteosarcoma

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Biological processes related to Localized Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.16 FRZB GLI2
2 negative regulation of cell growth GO:0030308 8.96 CDKN2A FRZB
3 cochlea morphogenesis GO:0090103 8.62 FRZB GLI2
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Sources for Localized Osteosarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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