Localized Pulmonary Fibrosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Localized Pulmonary Fibrosis

MalaCards integrated aliases for Localized Pulmonary Fibrosis:

Name: Localized Pulmonary Fibrosis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5642

NCIt ⁴⁹ C27103

SNOMED-CT ⁶⁷ 233726000

UMLS ⁷¹ C0340127

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Summaries for Localized Pulmonary Fibrosis

Disease Ontology : ¹² A pulmonary fibrosis that is characterized by localized destruction, scarring, and thickening of the lung parenchyma in a usual interstitial pneumonia pattern, eventually causing architectural distortion and honeycombing, has symptom progressive shortness of breath, fatigue, and chronic cough, possibly has material basis in exposure to certain chemicals, autoimmune conditions, and radiation.

MalaCards based summary : Localized Pulmonary Fibrosis is related to silo filler's disease and pleuroparenchymal fibroelastosis, and has symptoms including progressive shortness of breath An important gene associated with Localized Pulmonary Fibrosis is HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L), and among its related pathways/superpathways are Bacterial infections in CF airways and CLEC7A (Dectin-1) signaling. Affiliated tissues include lung.

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Related Diseases for Localized Pulmonary Fibrosis

Diseases in the Pulmonary Fibrosis family:

Localized Pulmonary Fibrosis

Pulmonary Fibrosis, Familial

Diseases related to Localized Pulmonary Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)

#	Related Disease	Score	Top Affiliating Genes
1	silo filler's disease	10.1	SFTPD IL1B
2	pleuroparenchymal fibroelastosis	10.1	SFTPD MUC1
3	bird fancier's lung	10.1	SFTPD MUC1
4	interstitial pneumonitis, desquamative, familial	10.1	SFTPD MUC1
5	acute interstitial pneumonia	10.1	SFTPD MUC1
6	cryptogenic organizing pneumonia	10.1	SFTPD MUC1
7	limbal stem cell deficiency	10.1	MUC1 IL1B
8	newborn respiratory distress syndrome	10.1	SFTPD IL1B
9	pneumocystosis	10.0	SFTPD MUC1
10	nonspecific interstitial pneumonia	10.0	SFTPD MUC1
11	mycoplasma pneumoniae pneumonia	10.0	SFTPD MUC1
12	silicosis	10.0	SFTPD IL1B
13	colonic lymphangioma	10.0	PDPN MUC1
14	eosinophilic pneumonia	10.0	SFTPD MUC1
15	benign peritoneal mesothelioma	10.0	PDPN MUC1
16	extrinsic allergic alveolitis	10.0	SFTPD IL1B
17	pulmonary alveolar proteinosis	10.0	SFTPD MUC1
18	asbestosis	10.0	MUC1 IL1B
19	sarcomatoid mesothelioma	10.0	PDPN MUC1
20	mucinous cystadenocarcinoma	10.0	PDPN MUC1
21	signet ring cell adenocarcinoma	9.9	PDPN MUC1
22	pancreatic ductal carcinoma	9.9	MUC1 IL1B
23	ectopic pregnancy	9.9	MUC1 IL1B
24	pre-malignant neoplasm	9.8	PDPN MUC1
25	in situ carcinoma	9.8	PDPN MUC1
26	bacterial pneumonia	9.7	SFTPD IL1B
27	pneumonia	9.7	SFTPD MUC1 IL1B
28	interstitial lung disease	9.7	SFTPD MUC1 IL1B
29	lung disease	9.7	SFTPD MUC1 IL1B
30	ciliary dyskinesia, primary, 10	9.7	PSMD5 PSMD4
31	ophthalmia nodosa	9.7	PSMD5 PSMD4
32	neurofibroma	9.7	PDPN MUC1
33	congenital disorder of glycosylation, type il	9.7	PSMD5 PSMD4
34	myasthenic syndrome, congenital, 21, presynaptic	9.7	PSMD5 PSMD4
35	pulmonary fibrosis, idiopathic	9.7	SFTPD MUC1 IL1B
36	retinitis pigmentosa 61	9.7	PSMD5 PSMD4
37	ciliary dyskinesia, primary, 9	9.7	PSMD5 PSMD4
38	cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction	9.7	PSMD5 PSMD4
39	retinitis pigmentosa 23	9.6	PSMD5 PSMD4
40	kaufman oculocerebrofacial syndrome	9.6	PSMD5 PSMD4
41	connective tissue disease	9.6	SFTPD MUC1 IL1B
42	hemangioblastoma	9.5	PDPN MUC1
43	wilson-turner x-linked mental retardation syndrome	9.4	PSMD5 PSMD4
44	hypotrichosis 1	9.4	PSMD5 PSMD4 IL1B
45	kagami-ogata syndrome	9.4	PSMD5 PSMD4 IL1B

Graphical network of the top 20 diseases related to Localized Pulmonary Fibrosis:

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Symptoms & Phenotypes for Localized Pulmonary Fibrosis

Symptoms:

¹²

• progressive shortness of breath

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Drugs & Therapeutics for Localized Pulmonary Fibrosis

Search Clinical Trials , NIH Clinical Center for Localized Pulmonary Fibrosis

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Genetic Tests for Localized Pulmonary Fibrosis

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Anatomical Context for Localized Pulmonary Fibrosis

MalaCards organs/tissues related to Localized Pulmonary Fibrosis:

⁴⁰

Lung

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Publications for Localized Pulmonary Fibrosis

Articles related to Localized Pulmonary Fibrosis:

#	Title	Authors	PMID	Year
1	Are pulmonary opacities a marker of pulmonary tuberculosis? ⁶¹	Marwah V...Rajput AK	24623942	2014
2	Pulmonary apical mass, the so-called pulmonary apical cap, in a 43-year-old woman. ⁶¹	Hirami Y...Tanemoto K	20930666	2010
3	Open lung biopsy of patients with rheumatoid arthritis. ⁶¹	Hakala M...Sutinen S	2088643	1990
4	Experimental tissue lesions related to extracorporeal lithotripsy of gallbladder. ⁶¹	Ponchon T...Capron F	2814755	1989
5	An experimental study on carcinogenesis related to localized fibrosis in the lung. ⁶¹	Ohwada H...Seki M	7418973	1980
6	Non-tuberculous chest disease found in a mass x-ray survey in Vancouver, B.C. ⁶¹	Mackenzie CJ	5911154	1966

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Genes for Localized Pulmonary Fibrosis

Genes related to Localized Pulmonary Fibrosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HNRNPL	Heterogeneous Nuclear Ribonucleoprotein L	Protein Coding	5.17	DISEASES inferred ¹⁵
2	AKT1S1	AKT1 Substrate 1	Protein Coding	4.91	DISEASES inferred ¹⁵
3	SFTPD	Surfactant Protein D	Protein Coding	4.83	DISEASES inferred ¹⁵
4	IL1B	Interleukin 1 Beta	Protein Coding	4.26	DISEASES inferred ¹⁵
5	PDPN	Podoplanin	Protein Coding	4.2	DISEASES inferred ¹⁵
6	PSMD5	Proteasome 26S Subunit, Non-ATPase 5	Protein Coding	4	DISEASES inferred ¹⁵
7	PSMD4	Proteasome 26S Subunit, Non-ATPase 4	Protein Coding	3.87	DISEASES inferred ¹⁵
8	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	3.87	DISEASES inferred ¹⁵

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Variations for Localized Pulmonary Fibrosis

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Expression for Localized Pulmonary Fibrosis

Search GEO for disease gene expression data for Localized Pulmonary Fibrosis.

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Pathways for Localized Pulmonary Fibrosis

Pathways related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	11.35	SFTPD MUC1 IL1B
2	CLEC7A (Dectin-1) signaling ⁶⁵ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁵ C-type lectin receptors (CLRs) ⁶⁵	11.34	PSMD5 PSMD4 MUC1 IL1B

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GO Terms for Localized Pulmonary Fibrosis

Cellular components related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	proteasome complex	GO:0000502	9.16	PSMD5 PSMD4
2	proteasome accessory complex	GO:0022624	8.96	PSMD5 PSMD4
3	proteasome regulatory particle, base subcomplex	GO:0008540	8.62	PSMD5 PSMD4

Biological processes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:0002479	9.51	PSMD5 PSMD4
2	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061418	9.49	PSMD5 PSMD4
3	NIK/NF-kappaB signaling	GO:0038061	9.48	PSMD5 PSMD4
4	regulation of hematopoietic stem cell differentiation	GO:1902036	9.46	PSMD5 PSMD4
5	negative regulation of G2/M transition of mitotic cell cycle	GO:0010972	9.43	PSMD5 PSMD4
6	MAPK cascade	GO:0000165	9.43	PSMD5 PSMD4 IL1B
7	regulation of cellular amino acid metabolic process	GO:0006521	9.4	PSMD5 PSMD4
8	positive regulation of phagocytosis	GO:0050766	9.37	SFTPD IL1B
9	positive regulation of epithelial to mesenchymal transition	GO:0010718	9.32	PDPN IL1B
10	proteasome assembly	GO:0043248	9.16	PSMD5 PSMD4
11	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.13	PSMD5 PSMD4 MUC1
12	interleukin-1-mediated signaling pathway	GO:0070498	8.8	PSMD5 PSMD4 IL1B

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Sources for Localized Pulmonary Fibrosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia