Localized Pulmonary Fibrosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Localized Pulmonary Fibrosis

MalaCards integrated aliases for Localized Pulmonary Fibrosis:

Name: Localized Pulmonary Fibrosis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5642

NCIt ⁵⁰ C27103

SNOMED-CT ⁶⁷ 233726000

UMLS ⁷¹ C0340127

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Summaries for Localized Pulmonary Fibrosis

Disease Ontology : ¹² A pulmonary fibrosis that is characterized by localized destruction, scarring, and thickening of the lung parenchyma in a usual interstitial pneumonia pattern, eventually causing architectural distortion and honeycombing, has symptom progressive shortness of breath, fatigue, and chronic cough, possibly has material basis in exposure to certain chemicals, autoimmune conditions, and radiation.

MalaCards based summary : Localized Pulmonary Fibrosis is related to pleuroparenchymal fibroelastosis and ventilation pneumonitis, and has symptoms including progressive shortness of breath An important gene associated with Localized Pulmonary Fibrosis is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Bacterial infections in CF airways and Interleukin-4 and 13 signaling. Related phenotype is Increased virus production.

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Related Diseases for Localized Pulmonary Fibrosis

Diseases in the Pulmonary Fibrosis family:

Localized Pulmonary Fibrosis

Pulmonary Fibrosis, Familial

Diseases related to Localized Pulmonary Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)

#	Related Disease	Score	Top Affiliating Genes
1	pleuroparenchymal fibroelastosis	10.0	SFTPD MUC1
2	ventilation pneumonitis	10.0	SFTPD MUC1
3	rheumatoid arthritis interstitial lung disease	10.0	SFTPD MUC1
4	bird fancier's lung	10.0	SFTPD MUC1
5	interstitial pneumonitis, desquamative, familial	10.0	SFTPD MUC1
6	cryptogenic organizing pneumonia	10.0	SFTPD MUC1
7	pneumocystosis	10.0	SFTPD MUC1
8	nonspecific interstitial pneumonia	10.0	SFTPD MUC1
9	mycoplasma pneumoniae pneumonia	10.0	SFTPD MUC1
10	eosinophilic pneumonia	10.0	SFTPD MUC1
11	pulmonary alveolar proteinosis	10.0	SFTPD MUC1
12	pulmonary fibrosis	10.0	SFTPD IL1B
13	limbal stem cell deficiency	10.0	MUC1 IL1B
14	silo filler's disease	10.0	SFTPD IL1B
15	silicosis	9.9	SFTPD IL1B
16	pancreatic ductal carcinoma	9.9	MUC1 IL1B
17	extrinsic allergic alveolitis	9.9	SFTPD IL1B
18	acute interstitial pneumonia	9.9	SFTPD MUC1
19	ectopic pregnancy	9.9	MUC1 IL1B
20	bacterial pneumonia	9.9	SFTPD IL1B
21	bronchiolitis	9.9	SFTPD IL1B
22	colonic lymphangioma	9.9	PDPN MUC1
23	benign peritoneal mesothelioma	9.9	PDPN MUC1
24	mucinous cystadenocarcinoma	9.9	PDPN MUC1
25	cystadenocarcinoma	9.8	PDPN MUC1
26	sarcomatoid mesothelioma	9.8	PDPN MUC1
27	signet ring cell adenocarcinoma	9.8	PDPN MUC1
28	aspergillosis	9.8	SFTPD IL1B
29	pre-malignant neoplasm	9.8	PDPN MUC1
30	sarcoidosis 1	9.8	SFTPD IL1B
31	in situ carcinoma	9.8	PDPN MUC1
32	neurofibroma	9.8	PDPN MUC1
33	hemangioblastoma	9.8	PDPN MUC1
34	myositis	9.8	MUC1 IL1B
35	angiosarcoma	9.8	PDPN MUC1
36	gastric cancer, hereditary diffuse	9.8	PDPN IL1B
37	adult respiratory distress syndrome	9.7	SFTPD IL1B
38	malignant pleural mesothelioma	9.7	PDPN MUC1
39	mesothelioma, malignant	9.7	PDPN MUC1
40	interstitial lung disease	9.7	SFTPD MUC1 IL1B
41	lung disease	9.7	SFTPD MUC1 IL1B
42	disease by infectious agent	9.7	SFTPD IL1B
43	pneumonia	9.7	SFTPD MUC1 IL1B
44	pulmonary fibrosis, idiopathic	9.7	SFTPD MUC1 IL1B
45	connective tissue disease	9.7	SFTPD MUC1 IL1B
46	pulmonary disease, chronic obstructive	9.6	SFTPD IL1B
47	cystic fibrosis	9.6	SFTPD MUC1 IL1B

Graphical network of the top 20 diseases related to Localized Pulmonary Fibrosis:

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Symptoms & Phenotypes for Localized Pulmonary Fibrosis

Symptoms:

¹²

• progressive shortness of breath

GenomeRNAi Phenotypes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased virus production	GR00378-A	8.62	MUC1 SFTPD

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Drugs & Therapeutics for Localized Pulmonary Fibrosis

Search Clinical Trials , NIH Clinical Center for Localized Pulmonary Fibrosis

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Genetic Tests for Localized Pulmonary Fibrosis

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Anatomical Context for Localized Pulmonary Fibrosis

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Publications for Localized Pulmonary Fibrosis

Articles related to Localized Pulmonary Fibrosis:

#	Title	Authors	PMID	Year
1	Are pulmonary opacities a marker of pulmonary tuberculosis? ⁶¹	Marwah V...Rajput AK	24623942	2014
2	Pulmonary apical mass, the so-called pulmonary apical cap, in a 43-year-old woman. ⁶¹	Hirami Y...Tanemoto K	20930666	2010
3	Open lung biopsy of patients with rheumatoid arthritis. ⁶¹	Hakala M...Sutinen S	2088643	1990
4	Experimental tissue lesions related to extracorporeal lithotripsy of gallbladder. ⁶¹	Ponchon T...Capron F	2814755	1989
5	An experimental study on carcinogenesis related to localized fibrosis in the lung. ⁶¹	Ohwada H...Seki M	7418973	1980
6	Non-tuberculous chest disease found in a mass x-ray survey in Vancouver, B.C. ⁶¹	Mackenzie CJ	5911154	1966

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Genes for Localized Pulmonary Fibrosis

Genes related to Localized Pulmonary Fibrosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SFTPD	Surfactant Protein D	Protein Coding	4.99	DISEASES inferred ¹⁵
2	IL1B	Interleukin 1 Beta	Protein Coding	4.38	DISEASES inferred ¹⁵
3	PDPN	Podoplanin	Protein Coding	4.31	DISEASES inferred ¹⁵
4	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	4.01	DISEASES inferred ¹⁵

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Variations for Localized Pulmonary Fibrosis

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Expression for Localized Pulmonary Fibrosis

Search GEO for disease gene expression data for Localized Pulmonary Fibrosis.

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Pathways for Localized Pulmonary Fibrosis

Pathways related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	11.02	SFTPD MUC1 IL1B
2	Interleukin-4 and 13 signaling ⁶⁵	11.01	MUC1 IL1B

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GO Terms for Localized Pulmonary Fibrosis

Biological processes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of phagocytosis	GO:0050766	8.96	SFTPD IL1B
2	positive regulation of epithelial to mesenchymal transition	GO:0010718	8.62	PDPN IL1B

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Sources for Localized Pulmonary Fibrosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia