MCID: LCL003
MIFTS: 20

Localized Pulmonary Fibrosis

Categories: Genetic diseases, Respiratory diseases

Aliases & Classifications for Localized Pulmonary Fibrosis

MalaCards integrated aliases for Localized Pulmonary Fibrosis:

Name: Localized Pulmonary Fibrosis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5642
NCIt 50 C27103
SNOMED-CT 67 233726000
UMLS 71 C0340127

Summaries for Localized Pulmonary Fibrosis

Disease Ontology : 12 A pulmonary fibrosis that is characterized by localized destruction, scarring, and thickening of the lung parenchyma in a usual interstitial pneumonia pattern, eventually causing architectural distortion and honeycombing, has symptom progressive shortness of breath, fatigue, and chronic cough, possibly has material basis in exposure to certain chemicals, autoimmune conditions, and radiation.

MalaCards based summary : Localized Pulmonary Fibrosis is related to pleuroparenchymal fibroelastosis and ventilation pneumonitis, and has symptoms including progressive shortness of breath An important gene associated with Localized Pulmonary Fibrosis is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are Bacterial infections in CF airways and Interleukin-4 and 13 signaling. Related phenotype is Increased virus production.

Related Diseases for Localized Pulmonary Fibrosis

Diseases in the Pulmonary Fibrosis family:

Localized Pulmonary Fibrosis Pulmonary Fibrosis, Familial

Diseases related to Localized Pulmonary Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 pleuroparenchymal fibroelastosis 10.0 SFTPD MUC1
2 ventilation pneumonitis 10.0 SFTPD MUC1
3 rheumatoid arthritis interstitial lung disease 10.0 SFTPD MUC1
4 bird fancier's lung 10.0 SFTPD MUC1
5 interstitial pneumonitis, desquamative, familial 10.0 SFTPD MUC1
6 cryptogenic organizing pneumonia 10.0 SFTPD MUC1
7 pneumocystosis 10.0 SFTPD MUC1
8 nonspecific interstitial pneumonia 10.0 SFTPD MUC1
9 mycoplasma pneumoniae pneumonia 10.0 SFTPD MUC1
10 eosinophilic pneumonia 10.0 SFTPD MUC1
11 pulmonary alveolar proteinosis 10.0 SFTPD MUC1
12 pulmonary fibrosis 10.0 SFTPD IL1B
13 limbal stem cell deficiency 10.0 MUC1 IL1B
14 silo filler's disease 10.0 SFTPD IL1B
15 silicosis 9.9 SFTPD IL1B
16 pancreatic ductal carcinoma 9.9 MUC1 IL1B
17 extrinsic allergic alveolitis 9.9 SFTPD IL1B
18 acute interstitial pneumonia 9.9 SFTPD MUC1
19 ectopic pregnancy 9.9 MUC1 IL1B
20 bacterial pneumonia 9.9 SFTPD IL1B
21 bronchiolitis 9.9 SFTPD IL1B
22 colonic lymphangioma 9.9 PDPN MUC1
23 benign peritoneal mesothelioma 9.9 PDPN MUC1
24 mucinous cystadenocarcinoma 9.9 PDPN MUC1
25 cystadenocarcinoma 9.8 PDPN MUC1
26 sarcomatoid mesothelioma 9.8 PDPN MUC1
27 signet ring cell adenocarcinoma 9.8 PDPN MUC1
28 aspergillosis 9.8 SFTPD IL1B
29 pre-malignant neoplasm 9.8 PDPN MUC1
30 sarcoidosis 1 9.8 SFTPD IL1B
31 in situ carcinoma 9.8 PDPN MUC1
32 neurofibroma 9.8 PDPN MUC1
33 hemangioblastoma 9.8 PDPN MUC1
34 myositis 9.8 MUC1 IL1B
35 angiosarcoma 9.8 PDPN MUC1
36 gastric cancer, hereditary diffuse 9.8 PDPN IL1B
37 adult respiratory distress syndrome 9.7 SFTPD IL1B
38 malignant pleural mesothelioma 9.7 PDPN MUC1
39 mesothelioma, malignant 9.7 PDPN MUC1
40 interstitial lung disease 9.7 SFTPD MUC1 IL1B
41 lung disease 9.7 SFTPD MUC1 IL1B
42 disease by infectious agent 9.7 SFTPD IL1B
43 pneumonia 9.7 SFTPD MUC1 IL1B
44 pulmonary fibrosis, idiopathic 9.7 SFTPD MUC1 IL1B
45 connective tissue disease 9.7 SFTPD MUC1 IL1B
46 pulmonary disease, chronic obstructive 9.6 SFTPD IL1B
47 cystic fibrosis 9.6 SFTPD MUC1 IL1B

Graphical network of the top 20 diseases related to Localized Pulmonary Fibrosis:



Diseases related to Localized Pulmonary Fibrosis

Symptoms & Phenotypes for Localized Pulmonary Fibrosis

Symptoms:

12
  • progressive shortness of breath

GenomeRNAi Phenotypes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased virus production GR00378-A 8.62 MUC1 SFTPD

Drugs & Therapeutics for Localized Pulmonary Fibrosis

Search Clinical Trials , NIH Clinical Center for Localized Pulmonary Fibrosis

Genetic Tests for Localized Pulmonary Fibrosis

Anatomical Context for Localized Pulmonary Fibrosis

Publications for Localized Pulmonary Fibrosis

Articles related to Localized Pulmonary Fibrosis:

# Title Authors PMID Year
1
Are pulmonary opacities a marker of pulmonary tuberculosis? 61
24623942 2014
2
Pulmonary apical mass, the so-called pulmonary apical cap, in a 43-year-old woman. 61
20930666 2010
3
Open lung biopsy of patients with rheumatoid arthritis. 61
2088643 1990
4
Experimental tissue lesions related to extracorporeal lithotripsy of gallbladder. 61
2814755 1989
5
An experimental study on carcinogenesis related to localized fibrosis in the lung. 61
7418973 1980
6
Non-tuberculous chest disease found in a mass x-ray survey in Vancouver, B.C. 61
5911154 1966

Variations for Localized Pulmonary Fibrosis

Expression for Localized Pulmonary Fibrosis

Search GEO for disease gene expression data for Localized Pulmonary Fibrosis.

Pathways for Localized Pulmonary Fibrosis

Pathways related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.02 SFTPD MUC1 IL1B
2 11.01 MUC1 IL1B

GO Terms for Localized Pulmonary Fibrosis

Biological processes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phagocytosis GO:0050766 8.96 SFTPD IL1B
2 positive regulation of epithelial to mesenchymal transition GO:0010718 8.62 PDPN IL1B

Sources for Localized Pulmonary Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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