MCID: LCL003
MIFTS: 23

Localized Pulmonary Fibrosis

Categories: Genetic diseases, Respiratory diseases

Aliases & Classifications for Localized Pulmonary Fibrosis

MalaCards integrated aliases for Localized Pulmonary Fibrosis:

Name: Localized Pulmonary Fibrosis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5642
NCIt 49 C27103
SNOMED-CT 67 233726000
UMLS 71 C0340127

Summaries for Localized Pulmonary Fibrosis

Disease Ontology : 12 A pulmonary fibrosis that is characterized by localized destruction, scarring, and thickening of the lung parenchyma in a usual interstitial pneumonia pattern, eventually causing architectural distortion and honeycombing, has symptom progressive shortness of breath, fatigue, and chronic cough, possibly has material basis in exposure to certain chemicals, autoimmune conditions, and radiation.

MalaCards based summary : Localized Pulmonary Fibrosis is related to silo filler's disease and pleuroparenchymal fibroelastosis, and has symptoms including progressive shortness of breath An important gene associated with Localized Pulmonary Fibrosis is HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L), and among its related pathways/superpathways are Bacterial infections in CF airways and CLEC7A (Dectin-1) signaling. Affiliated tissues include lung.

Related Diseases for Localized Pulmonary Fibrosis

Diseases in the Pulmonary Fibrosis family:

Localized Pulmonary Fibrosis Pulmonary Fibrosis, Familial

Diseases related to Localized Pulmonary Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 silo filler's disease 10.1 SFTPD IL1B
2 pleuroparenchymal fibroelastosis 10.1 SFTPD MUC1
3 bird fancier's lung 10.1 SFTPD MUC1
4 interstitial pneumonitis, desquamative, familial 10.1 SFTPD MUC1
5 acute interstitial pneumonia 10.1 SFTPD MUC1
6 cryptogenic organizing pneumonia 10.1 SFTPD MUC1
7 limbal stem cell deficiency 10.1 MUC1 IL1B
8 newborn respiratory distress syndrome 10.1 SFTPD IL1B
9 pneumocystosis 10.0 SFTPD MUC1
10 nonspecific interstitial pneumonia 10.0 SFTPD MUC1
11 mycoplasma pneumoniae pneumonia 10.0 SFTPD MUC1
12 silicosis 10.0 SFTPD IL1B
13 colonic lymphangioma 10.0 PDPN MUC1
14 eosinophilic pneumonia 10.0 SFTPD MUC1
15 benign peritoneal mesothelioma 10.0 PDPN MUC1
16 extrinsic allergic alveolitis 10.0 SFTPD IL1B
17 pulmonary alveolar proteinosis 10.0 SFTPD MUC1
18 asbestosis 10.0 MUC1 IL1B
19 sarcomatoid mesothelioma 10.0 PDPN MUC1
20 mucinous cystadenocarcinoma 10.0 PDPN MUC1
21 signet ring cell adenocarcinoma 9.9 PDPN MUC1
22 pancreatic ductal carcinoma 9.9 MUC1 IL1B
23 ectopic pregnancy 9.9 MUC1 IL1B
24 pre-malignant neoplasm 9.8 PDPN MUC1
25 in situ carcinoma 9.8 PDPN MUC1
26 bacterial pneumonia 9.7 SFTPD IL1B
27 pneumonia 9.7 SFTPD MUC1 IL1B
28 interstitial lung disease 9.7 SFTPD MUC1 IL1B
29 lung disease 9.7 SFTPD MUC1 IL1B
30 ciliary dyskinesia, primary, 10 9.7 PSMD5 PSMD4
31 ophthalmia nodosa 9.7 PSMD5 PSMD4
32 neurofibroma 9.7 PDPN MUC1
33 congenital disorder of glycosylation, type il 9.7 PSMD5 PSMD4
34 myasthenic syndrome, congenital, 21, presynaptic 9.7 PSMD5 PSMD4
35 pulmonary fibrosis, idiopathic 9.7 SFTPD MUC1 IL1B
36 retinitis pigmentosa 61 9.7 PSMD5 PSMD4
37 ciliary dyskinesia, primary, 9 9.7 PSMD5 PSMD4
38 cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction 9.7 PSMD5 PSMD4
39 retinitis pigmentosa 23 9.6 PSMD5 PSMD4
40 kaufman oculocerebrofacial syndrome 9.6 PSMD5 PSMD4
41 connective tissue disease 9.6 SFTPD MUC1 IL1B
42 hemangioblastoma 9.5 PDPN MUC1
43 wilson-turner x-linked mental retardation syndrome 9.4 PSMD5 PSMD4
44 hypotrichosis 1 9.4 PSMD5 PSMD4 IL1B
45 kagami-ogata syndrome 9.4 PSMD5 PSMD4 IL1B

Graphical network of the top 20 diseases related to Localized Pulmonary Fibrosis:



Diseases related to Localized Pulmonary Fibrosis

Symptoms & Phenotypes for Localized Pulmonary Fibrosis

Symptoms:

12
  • progressive shortness of breath

Drugs & Therapeutics for Localized Pulmonary Fibrosis

Search Clinical Trials , NIH Clinical Center for Localized Pulmonary Fibrosis

Genetic Tests for Localized Pulmonary Fibrosis

Anatomical Context for Localized Pulmonary Fibrosis

MalaCards organs/tissues related to Localized Pulmonary Fibrosis:

40
Lung

Publications for Localized Pulmonary Fibrosis

Articles related to Localized Pulmonary Fibrosis:

# Title Authors PMID Year
1
Are pulmonary opacities a marker of pulmonary tuberculosis? 61
24623942 2014
2
Pulmonary apical mass, the so-called pulmonary apical cap, in a 43-year-old woman. 61
20930666 2010
3
Open lung biopsy of patients with rheumatoid arthritis. 61
2088643 1990
4
Experimental tissue lesions related to extracorporeal lithotripsy of gallbladder. 61
2814755 1989
5
An experimental study on carcinogenesis related to localized fibrosis in the lung. 61
7418973 1980
6
Non-tuberculous chest disease found in a mass x-ray survey in Vancouver, B.C. 61
5911154 1966

Variations for Localized Pulmonary Fibrosis

Expression for Localized Pulmonary Fibrosis

Search GEO for disease gene expression data for Localized Pulmonary Fibrosis.

Pathways for Localized Pulmonary Fibrosis

Pathways related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 SFTPD MUC1 IL1B
2
Show member pathways
11.34 PSMD5 PSMD4 MUC1 IL1B

GO Terms for Localized Pulmonary Fibrosis

Cellular components related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteasome complex GO:0000502 9.16 PSMD5 PSMD4
2 proteasome accessory complex GO:0022624 8.96 PSMD5 PSMD4
3 proteasome regulatory particle, base subcomplex GO:0008540 8.62 PSMD5 PSMD4

Biological processes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.51 PSMD5 PSMD4
2 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.49 PSMD5 PSMD4
3 NIK/NF-kappaB signaling GO:0038061 9.48 PSMD5 PSMD4
4 regulation of hematopoietic stem cell differentiation GO:1902036 9.46 PSMD5 PSMD4
5 negative regulation of G2/M transition of mitotic cell cycle GO:0010972 9.43 PSMD5 PSMD4
6 MAPK cascade GO:0000165 9.43 PSMD5 PSMD4 IL1B
7 regulation of cellular amino acid metabolic process GO:0006521 9.4 PSMD5 PSMD4
8 positive regulation of phagocytosis GO:0050766 9.37 SFTPD IL1B
9 positive regulation of epithelial to mesenchymal transition GO:0010718 9.32 PDPN IL1B
10 proteasome assembly GO:0043248 9.16 PSMD5 PSMD4
11 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.13 PSMD5 PSMD4 MUC1
12 interleukin-1-mediated signaling pathway GO:0070498 8.8 PSMD5 PSMD4 IL1B

Sources for Localized Pulmonary Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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