MCID: LCL003
MIFTS: 20

Localized Pulmonary Fibrosis

Categories: Respiratory diseases
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Aliases & Classifications for Localized Pulmonary Fibrosis

MalaCards integrated aliases for Localized Pulmonary Fibrosis:

Name: Localized Pulmonary Fibrosis 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5642
NCIt 49 C27103
SNOMED-CT 68 233726000
UMLS 71 C0340127

Summaries for Localized Pulmonary Fibrosis

Disease Ontology: 11 A pulmonary fibrosis that is characterized by localized destruction, scarring, and thickening of the lung parenchyma in a usual interstitial pneumonia pattern, eventually causing architectural distortion and honeycombing, has symptom progressive shortness of breath, fatigue, and chronic cough, possibly has material basis in exposure to certain chemicals, autoimmune conditions, and radiation.

MalaCards based summary: Localized Pulmonary Fibrosis is related to ventilation pneumonitis and bird fancier's lung, and has symptoms including progressive shortness of breath An important gene associated with Localized Pulmonary Fibrosis is SFTPD (Surfactant Protein D), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Bacterial infections in CF airways. Affiliated tissues include lung, and related phenotype is Increased virus production.

Related Diseases for Localized Pulmonary Fibrosis

Diseases in the Pulmonary Fibrosis family:

Localized Pulmonary Fibrosis

Diseases related to Localized Pulmonary Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 ventilation pneumonitis 10.0 SFTPD MUC1
2 bird fancier's lung 10.0 SFTPD MUC1
3 interstitial pneumonitis, desquamative, familial 10.0 SFTPD MUC1
4 acute interstitial pneumonia 10.0 SFTPD MUC1
5 cryptogenic organizing pneumonia 10.0 SFTPD MUC1
6 nonspecific interstitial pneumonia 10.0 SFTPD MUC1
7 pneumocystosis 10.0 SFTPD MUC1
8 idiopathic interstitial pneumonia 10.0 SFTPD MUC1
9 extrinsic allergic alveolitis 10.0 SFTPD MUC1
10 bronchiolitis obliterans 10.0 SFTPD MUC1
11 pulmonary alveolar proteinosis 10.0 SFTPD MUC1
12 colonic lymphangioma 10.0 PDPN MUC1
13 lymphangitis 9.9 PDPN MUC1
14 benign peritoneal mesothelioma 9.9 PDPN MUC1
15 gallbladder adenocarcinoma 9.9 PDPN MUC1
16 large cell carcinoma 9.9 SFTPD MUC1
17 signet ring cell adenocarcinoma 9.9 PDPN MUC1
18 breast carcinoma in situ 9.9 PDPN MUC1
19 ductal carcinoma in situ 9.9 PDPN MUC1
20 pre-malignant neoplasm 9.9 PDPN MUC1
21 hemangioblastoma 9.9 PDPN MUC1
22 angiosarcoma 9.9 PDPN MUC1
23 cystadenocarcinoma 9.9 PDPN MUC1
24 neurofibroma 9.9 PDPN MUC1
25 pulmonary fibrosis 9.9 SFTPD IL1B
26 pneumonia 9.9 SFTPD IL1B
27 dry eye syndrome 9.8 MUC1 IL1B
28 bacterial pneumonia 9.8 SFTPD IL1B
29 bronchiolitis 9.8 SFTPD IL1B
30 lymphangioma 9.8 PDPN IL1B
31 aspergillosis 9.8 SFTPD IL1B
32 mesothelioma, malignant 9.8 PDPN MUC1
33 otitis media 9.8 SFTPD IL1B
34 breast adenocarcinoma 9.7 MUC1 IL1B
35 allergic disease 9.7 SFTPD IL1B
36 hemangioma 9.7 PDPN MUC1
37 sarcoidosis 1 9.7 SFTPD IL1B
38 kaposi sarcoma 9.7 PDPN IL1B
39 adult respiratory distress syndrome 9.7 SFTPD IL1B
40 anaerobic pneumonia 9.6 SFTPD MUC1 IL1B
41 silicosis 9.6 SFTPD MUC1 IL1B
42 interstitial lung disease 9.6 SFTPD MUC1 IL1B
43 pulmonary disease, chronic obstructive 9.6 SFTPD IL1B
44 interstitial lung disease 2 9.6 SFTPD MUC1 IL1B
45 respiratory failure 9.5 SFTPD IL1B
46 cystic fibrosis 9.4 SFTPD MUC1 IL1B

Graphical network of the top 20 diseases related to Localized Pulmonary Fibrosis:



Diseases related to Localized Pulmonary Fibrosis

Symptoms & Phenotypes for Localized Pulmonary Fibrosis

Symptoms:

11
  • progressive shortness of breath

GenomeRNAi Phenotypes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased virus production GR00378-A 8.62 MUC1 SFTPD

Drugs & Therapeutics for Localized Pulmonary Fibrosis

Search Clinical Trials, NIH Clinical Center for Localized Pulmonary Fibrosis

Genetic Tests for Localized Pulmonary Fibrosis

Anatomical Context for Localized Pulmonary Fibrosis

Organs/tissues related to Localized Pulmonary Fibrosis:

MalaCards : Lung

Publications for Localized Pulmonary Fibrosis

Articles related to Localized Pulmonary Fibrosis:

# Title Authors PMID Year
1
Are pulmonary opacities a marker of pulmonary tuberculosis? 62
24623942 2014
2
Pulmonary apical mass, the so-called pulmonary apical cap, in a 43-year-old woman. 62
20930666 2010
3
Open lung biopsy of patients with rheumatoid arthritis. 62
2088643 1990
4
Experimental tissue lesions related to extracorporeal lithotripsy of gallbladder. 62
2814755 1989
5
An experimental study on carcinogenesis related to localized fibrosis in the lung. 62
7418973 1980
6
Non-tuberculous chest disease found in a mass x-ray survey in Vancouver, B.C. 62
5911154 1966

Variations for Localized Pulmonary Fibrosis

Expression for Localized Pulmonary Fibrosis

Search GEO for disease gene expression data for Localized Pulmonary Fibrosis.

Pathways for Localized Pulmonary Fibrosis

Pathways related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.56 MUC1 IL1B
2
Show member pathways
11.2 SFTPD MUC1 IL1B
3 10.99 MUC1 IL1B

GO Terms for Localized Pulmonary Fibrosis

Biological processes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of epithelial to mesenchymal transition GO:0010718 9.26 PDPN IL1B
2 positive regulation of phagocytosis GO:0050766 8.92 SFTPD IL1B

Sources for Localized Pulmonary Fibrosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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