Localized Pulmonary Fibrosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Localized Pulmonary Fibrosis

MalaCards integrated aliases for Localized Pulmonary Fibrosis:

Name: Localized Pulmonary Fibrosis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Global: Genetic diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5642

NCIt ⁴⁹ C27103

UMLS ⁷¹ C0340127

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Summaries for Localized Pulmonary Fibrosis

Disease Ontology : ¹² A pulmonary fibrosis that is characterized by localized destruction, scarring, and thickening of the lung parenchyma in a usual interstitial pneumonia pattern, eventually causing architectural distortion and honeycombing, has symptom progressive shortness of breath, fatigue, and chronic cough, possibly has material basis in exposure to certain chemicals, autoimmune conditions, and radiation.

MalaCards based summary : Localized Pulmonary Fibrosis is related to ophthalmia nodosa and ciliary dyskinesia, primary, 10, and has symptoms including progressive shortness of breath An important gene associated with Localized Pulmonary Fibrosis is ANKRD11 (Ankyrin Repeat Domain 11), and among its related pathways/superpathways are HIV Life Cycle and Bacterial infections in CF airways. Affiliated tissues include lung.

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Related Diseases for Localized Pulmonary Fibrosis

Diseases in the Pulmonary Fibrosis family:

Localized Pulmonary Fibrosis

Pulmonary Fibrosis, Familial

Diseases related to Localized Pulmonary Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)

#	Related Disease	Score	Top Affiliating Genes
1	ophthalmia nodosa	10.0	PSMD5 PSMD4
2	ciliary dyskinesia, primary, 10	10.0	PSMD5 PSMD4
3	pleuroparenchymal fibroelastosis	10.0	SFTPD MUC1
4	ciliary dyskinesia, primary, 9	10.0	PSMD5 PSMD4
5	bird fancier's lung	10.0	SFTPD MUC1
6	cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction	10.0	PSMD5 PSMD4
7	interstitial pneumonitis, desquamative, familial	10.0	SFTPD MUC1
8	acute interstitial pneumonia	10.0	SFTPD MUC1
9	cryptogenic organizing pneumonia	10.0	SFTPD MUC1
10	newborn respiratory distress syndrome	10.0	SFTPD IL1B
11	pneumocystosis	10.0	SFTPD MUC1
12	nonspecific interstitial pneumonia	10.0	SFTPD MUC1
13	mycoplasma pneumoniae pneumonia	9.9	SFTPD MUC1
14	retinitis pigmentosa 23	9.9	PSMD5 PSMD4
15	eosinophilic pneumonia	9.9	SFTPD MUC1
16	silicosis	9.9	SFTPD IL1B
17	limbal stem cell deficiency	9.9	MUC1 IL1B
18	hypotrichosis 1	9.9	PSMD5 PSMD4
19	pulmonary alveolar proteinosis	9.9	SFTPD MUC1
20	extrinsic allergic alveolitis	9.8	SFTPD IL1B
21	glossitis	9.7	TTR IL1B
22	gallbladder signet ring cell adenocarcinoma	9.7	TTR MUC1
23	chronic ethmoiditis	9.7	TTR MUC1
24	dysentery	9.7	TTR IL1B
25	wilson-turner x-linked mental retardation syndrome	9.7	PSMD5 PSMD4
26	papilloma of choroid plexus	9.7	TTR MUC1
27	ectopic pregnancy	9.6	MUC1 IL1B
28	benign ependymoma	9.6	TTR MUC1
29	interstitial lung disease	9.6	SFTPD MUC1 IL1B
30	lung disease	9.6	SFTPD MUC1 IL1B
31	carpal tunnel syndrome	9.6	TTR IL1B
32	pulmonary fibrosis, idiopathic	9.5	SFTPD MUC1 IL1B
33	connective tissue disease	9.4	SFTPD MUC1 IL1B
34	respiratory failure	9.4	TTR SFTPD IL1B
35	noonan syndrome 1	9.1	PSMD5 PSMD4 IL1B
36	pneumonia	9.0	TTR SFTPD MUC1 IL1B

Graphical network of the top 20 diseases related to Localized Pulmonary Fibrosis:

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Symptoms & Phenotypes for Localized Pulmonary Fibrosis

Symptoms:

¹²

• progressive shortness of breath

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Drugs & Therapeutics for Localized Pulmonary Fibrosis

Search Clinical Trials , NIH Clinical Center for Localized Pulmonary Fibrosis

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Genetic Tests for Localized Pulmonary Fibrosis

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Anatomical Context for Localized Pulmonary Fibrosis

MalaCards organs/tissues related to Localized Pulmonary Fibrosis:

⁴⁰

Lung

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Publications for Localized Pulmonary Fibrosis

Articles related to Localized Pulmonary Fibrosis:

#	Title	Authors	PMID	Year
1	Are pulmonary opacities a marker of pulmonary tuberculosis? ⁶¹	Marwah V...Rajput AK	24623942	2014
2	Pulmonary apical mass, the so-called pulmonary apical cap, in a 43-year-old woman. ⁶¹	Hirami Y...Tanemoto K	20930666	2010
3	Open lung biopsy of patients with rheumatoid arthritis. ⁶¹	Hakala M...Sutinen S	2088643	1990
4	Experimental tissue lesions related to extracorporeal lithotripsy of gallbladder. ⁶¹	Ponchon T...Capron F	2814755	1989
5	An experimental study on carcinogenesis related to localized fibrosis in the lung. ⁶¹	Ohwada H...Seki M	7418973	1980
6	Non-tuberculous chest disease found in a mass x-ray survey in Vancouver, B.C. ⁶¹	Mackenzie CJ	5911154	1966

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Genes for Localized Pulmonary Fibrosis

Genes related to Localized Pulmonary Fibrosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ANKRD11	Ankyrin Repeat Domain 11	Protein Coding	5.2	DISEASES inferred ¹⁵
2	AKT1S1	AKT1 Substrate 1	Protein Coding	5.01	DISEASES inferred ¹⁵
3	SFTPD	Surfactant Protein D	Protein Coding	4.95	DISEASES inferred ¹⁵
4	PSMD5	Proteasome 26S Subunit, Non-ATPase 5	Protein Coding	4.17	DISEASES inferred ¹⁵
5	PSMD4	Proteasome 26S Subunit, Non-ATPase 4	Protein Coding	4.05	DISEASES inferred ¹⁵
6	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	3.95	DISEASES inferred ¹⁵
7	TTR	Transthyretin	Protein Coding	3.86	DISEASES inferred ¹⁵
8	IL1B	Interleukin 1 Beta	Protein Coding	3.36	DISEASES inferred ¹⁵

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Variations for Localized Pulmonary Fibrosis

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Expression for Localized Pulmonary Fibrosis

Search GEO for disease gene expression data for Localized Pulmonary Fibrosis.

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Pathways for Localized Pulmonary Fibrosis

Pathways related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	HIV Life Cycle ⁶⁵ Show member pathways 2-LTR circle formation ⁶⁵ APOBEC3G mediated resistance to HIV-1 infection ⁶⁵ Assembly Of The HIV Virion ⁶⁵ Binding and entry of HIV virion ⁶⁵ Disease ⁶⁵ Diseases of signal transduction ⁶⁵ Early Phase of HIV Life Cycle ⁶⁵ HIV Infection ⁶⁵ Host Interactions of HIV factors ⁶⁵ Infectious disease ⁶⁵ Integration of provirus ⁶⁵ Late Phase of HIV Life Cycle ⁶⁵	12.8	TTR SFTPD PSMD5 PSMD4 MUC1 AKT1S1
2	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	11.55	SFTPD MUC1 IL1B
3	CLEC7A (Dectin-1) signaling ⁶⁵ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁵ C-type lectin receptors (CLRs) ⁶⁵	11.34	PSMD5 PSMD4 MUC1 IL1B

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GO Terms for Localized Pulmonary Fibrosis

Cellular components related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	proteasome complex	GO:0000502	9.16	PSMD5 PSMD4
2	proteasome accessory complex	GO:0022624	8.96	PSMD5 PSMD4
3	proteasome regulatory particle, base subcomplex	GO:0008540	8.62	PSMD5 PSMD4

Biological processes related to Localized Pulmonary Fibrosis according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:0002479	9.49	PSMD5 PSMD4
2	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:0061418	9.48	PSMD5 PSMD4
3	NIK/NF-kappaB signaling	GO:0038061	9.46	PSMD5 PSMD4
4	regulation of hematopoietic stem cell differentiation	GO:1902036	9.43	PSMD5 PSMD4
5	MAPK cascade	GO:0000165	9.43	PSMD5 PSMD4 IL1B
6	negative regulation of G2/M transition of mitotic cell cycle	GO:0010972	9.4	PSMD5 PSMD4
7	regulation of cellular amino acid metabolic process	GO:0006521	9.37	PSMD5 PSMD4
8	positive regulation of phagocytosis	GO:0050766	9.32	SFTPD IL1B
9	proteasome assembly	GO:0043248	9.16	PSMD5 PSMD4
10	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.13	PSMD5 PSMD4 MUC1
11	interleukin-1-mediated signaling pathway	GO:0070498	8.8	PSMD5 PSMD4 IL1B

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Sources for Localized Pulmonary Fibrosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁹ Cosmic

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

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⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia