MCID: LCK001
MIFTS: 47

Locked-in Syndrome

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Locked-in Syndrome

MalaCards integrated aliases for Locked-in Syndrome:

Name: Locked-in Syndrome 11 19 52 58 75 43 14 71 33
Cerebromedullospinal Disconnection 19 58
Locked in Syndrome 11 19
Locked-in State 11
Quadriplegia 71

Characteristics:


Prevelance:

<1/1000000 (Worldwide) 58

Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 11 DOID:12697
ICD9CM 34 344.81
MeSH 43 D000080422
SNOMED-CT 68 38023001
ICD10 via Orphanet 32 G83.8
UMLS via Orphanet 72 C0023944
Orphanet 58 ORPHA2406
ICD11 33 17562655
UMLS 71 C0023944 C0034372

Summaries for Locked-in Syndrome

GARD: 19 Locked-in syndrome is a rare neurological disorder characterized by complete paralysis of voluntary muscles, except for those that control the eyes. People with Locked-in syndrome are conscious and can think and reason, but are unable to speak or move. Vertical eye movements and blinking can be used to communicate. Locked-in syndrome may be caused by brain stem stroke, traumatic brain injury, tumors, diseases of the circulatory system (bleeding), diseases that destroy the myelin sheath surrounding nerve cells (like multiple sclerosis), infection, or medication overdose.

MalaCards based summary: Locked-in Syndrome, also known as cerebromedullospinal disconnection, is related to progressive bulbar palsy and lateral sclerosis, and has symptoms including muscle weakness, ophthalmoplegia and hemiplegia. An important gene associated with Locked-in Syndrome is CPZ (Carboxypeptidase Z), and among its related pathways/superpathways is Amyotrophic lateral sclerosis (ALS). The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and spinal cord, and related phenotypes are spasticity and diplopia

NINDS: 52 Locked-in syndrome is a rare neurological disorder characterized by complete paralysis of voluntary muscles in all parts of the body except for those that control eye movement. It may result from traumatic brain injury, diseases of the circulatory system, diseases that destroy the myelin sheath surrounding nerve cells, or medication overdose. Individuals with locked-in syndrome are conscious and can think and reason, but are unable to speak or move. The disorder leaves individuals completely mute and paralyzed. Communication may be possible with blinking eye movements

Orphanet: 58 Locked-in syndrome (LIS) is a neurological condition characterized by the presence of sustained eye opening, quadriplegia or quadriparesis, anarthria, preserved cognitive functioning and a primary code of communication that uses vertical eye movements or blinking.

Disease Ontology: 11 A nervous system disease that is characterized by complete paralysis of all voluntary muscles except for the ones that control the movements of the eyes.

Wikipedia: 75 Locked-in syndrome (LIS), also known as pseudocoma, is a condition in which a patient is aware but... more...

Related Diseases for Locked-in Syndrome

Diseases related to Locked-in Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 progressive bulbar palsy 30.2 SOD1 FUS ALS2
2 lateral sclerosis 30.1 TARDBP SOD1 FUS ALS2
3 motor neuron disease 30.0 TARDBP SOD1 FUS ALS2
4 aphasia 30.0 TARDBP PLG FUS
5 supranuclear palsy, progressive, 1 29.8 TARDBP SOD1 FUS
6 respiratory failure 29.7 SOD1 PLG LMOD3 KLHL40
7 neuromuscular disease 29.7 TARDBP SOD1 KLHL40 FUS ALS2
8 frontotemporal dementia 29.7 TARDBP SOD1 FUS ALS2
9 frontotemporal dementia and/or amyotrophic lateral sclerosis 1 29.7 TARDBP SOD1 FUS ALS2
10 movement disease 29.6 TARDBP SOD1 FUS
11 central pontine myelinolysis 11.1
12 quadriplegia 10.7
13 mutism 10.5
14 ocular motor apraxia 10.5
15 basilar artery occlusion 10.4
16 akinetic mutism 10.4
17 brain stem infarction 10.3
18 cranial nerve palsy 10.3
19 ptosis 10.3
20 conjugate gaze palsy 10.2
21 severe congenital nemaline myopathy 10.2 LMOD3 KLHL40
22 spinal muscular atrophy type 0 10.2 LMOD3 KLHL40
23 amyotrophic lateral sclerosis type 15 10.2 SOD1 ALS2
24 amyotrophic lateral sclerosis 20 10.2 SOD1 ALS2
25 nemaline myopathy 9 10.2 LMOD3 KLHL40
26 nemaline myopathy 11, autosomal recessive 10.2 LMOD3 KLHL40
27 amyotrophic lateral sclerosis 1 10.2
28 kearns-sayre syndrome 10.2
29 thrombosis 10.2
30 distal hereditary motor neuronopathy type 7 10.2 TARDBP ALS2
31 nemaline myopathy 10 10.2 LMOD3 KLHL40
32 amyotrophic lateral sclerosis, juvenile, with dementia 10.2 TARDBP AFF1
33 nemaline myopathy 8 10.2 LMOD3 KLHL40
34 hypoglycemia 10.2
35 juvenile amyotrophic lateral sclerosis 10.2 FUS ALS2
36 neuronopathy, distal hereditary motor, type viib 10.1 TARDBP ALS2
37 neuronopathy, distal hereditary motor, type iia 10.1 LMOD3 KLHL40 ALS2
38 ideomotor apraxia 10.1 TARDBP FUS
39 nominal aphasia 10.1 TARDBP FUS
40 prosopagnosia 10.1 TARDBP FUS
41 guillain-barre syndrome, familial 10.1
42 otitis media 10.1
43 hydrocephalus 10.1
44 guillain-barre syndrome 10.1
45 vascular disease 10.1
46 cerebrovascular disease 10.1
47 pathologic nystagmus 10.1
48 myoclonus 10.1
49 amyotrophic lateral sclerosis 19 10.1 TARDBP SOD1 ALS2
50 nemaline myopathy 2 10.1 LMOD3 KLHL40

Graphical network of the top 20 diseases related to Locked-in Syndrome:



Diseases related to Locked-in Syndrome

Symptoms & Phenotypes for Locked-in Syndrome

Human phenotypes related to Locked-in Syndrome:

58 30 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 spasticity 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001257
2 diplopia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0000651
3 tetraplegia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002445
4 respiratory insufficiency 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002093
5 behavioral abnormality 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0000708
6 abnormality of the voice 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001608
7 cerebral palsy 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0100021
8 tetraparesis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002273
9 anarthria 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002425
10 recurrent respiratory infections 58 30 Frequent (33%) Frequent (79-30%)
HP:0002205
11 feeding difficulties 58 30 Frequent (33%) Frequent (79-30%)
HP:0011968
12 excessive salivation 58 30 Frequent (33%) Frequent (79-30%)
HP:0003781
13 hearing impairment 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000365
14 hypertonia 58 Very frequent (99-80%)
15 abnormality of the eye 58 Very frequent (99-80%)
16 abnormality of vision 58 Very frequent (99-80%)

UMLS symptoms related to Locked-in Syndrome:


muscle weakness; ophthalmoplegia; hemiplegia; quadriparesis; other quadriplegia

MGI Mouse Phenotypes related to Locked-in Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.73 AFF1 ALS2 ARHGEF16 ERI1 FUS KLHL40
2 mortality/aging MP:0010768 9.36 AFF1 ALS2 ERI1 FUS KLHL40 LMOD3

Drugs & Therapeutics for Locked-in Syndrome

Drugs for Locked-in Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
2
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
3
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
4
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
5 Anesthetics Phase 4
6 Anesthetics, General Phase 4
7 Omega 3 Fatty Acid Phase 4
8 Neurotransmitter Agents Phase 4
9 Adrenergic alpha-Agonists Phase 4
10 Adrenergic Agonists Phase 4
11 Adrenergic Agents Phase 4
12 Vasoconstrictor Agents Phase 4
13 Sympathomimetics Phase 4
14
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
15
Arginine Approved, Investigational, Nutraceutical Phase 2, Phase 3 74-79-3 6322
16 NG-Nitroarginine Methyl Ester Phase 2, Phase 3
17
Buspirone Approved, Investigational Phase 1, Phase 2 36505-84-7 2477
18 Anti-Anxiety Agents Phase 1, Phase 2
19 Psychotropic Drugs Phase 1, Phase 2
20 Serotonin Receptor Agonists Phase 1, Phase 2
21
Serotonin Investigational, Nutraceutical Phase 1, Phase 2 50-67-9 5202
22
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 1 55-56-1 2713 9552079
23 Chlorhexidine gluconate Phase 1
24 Antioxidants Phase 1
25 Hemostatics Phase 1
26 Protective Agents Phase 1
27 Papaya Approved
28
Mometasone furoate Approved, Investigational, Vet_approved 83919-23-7 4240 441336
29
Ipratropium Approved, Experimental 22254-24-6, 60205-81-4 657309 3746
30
Silicon Approved, Investigational 7440-21-3 4082203
31
Metronidazole Approved 443-48-1, 69198-10-3 4173
32 Insulin, Globin Zinc
33
Insulin
34 Bronchodilator Agents
35 Anti-Asthmatic Agents
36 Respiratory System Agents
37 Cholinergic Antagonists
38 Cholinergic Agents
39 Vitamins
40 Whey Protein
41 Complement C3

Interventional clinical trials:

(show top 50) (show all 127)
# Name Status NCT ID Phase Drugs
1 Early Nerve Reconstruction Approach in Tetraplegic Patients With Dysfunctional Upper Extremity: a Randomized Controlled Trial. Unknown status NCT01579604 Phase 4
2 Omega-3 Supplementation to Increase HDL-c Levels in Those With Tetraplegia Completed NCT01896037 Phase 4
3 Melatonin Replacement for Treatment of Sleep Disruption Completed NCT00507546 Phase 4 Ramelteon;Placebo
4 Core Temperature During Cold Exposure in Persons With Tetraplegia Completed NCT01822535 Phase 4 Midodrine hydrochloride
5 Phrenic Reinnervation in Central Ventilatory Paralysis Due to Medullary Trauma With Phrenic Motoneuron Destruction Completed NCT01350297 Phase 4
6 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Active, not recruiting NCT02379156 Phase 4 Midodrine Hydrochloride
7 Activity-Dependent Plasticity After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
8 Evaluation of the Efficacy of "MEOPA" Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. Completed NCT00632528 Phase 3 MEOPA;Medicinal air
9 Outcome Evaluation of Exercise and Electrical Therapy for Quadriplegic Hand Function Completed NCT00656149 Phase 2, Phase 3
10 The Effect of Nitric Oxide on Pulmonary Resistances and Blood Pressure in Persons With Tetraplegia Completed NCT00753948 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
11 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed NCT00237770 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
12 Improving Hand Function in Chronic SCI With Combined Robotic Training and tDCS Active, not recruiting NCT03555838 Phase 3
13 Randomised Open Study of the Efficiency and Tolerance of the Use of a Corset on the Respiratory Function of Spinal Cord Injury Patients Withdrawn NCT01569360 Phase 3
14 ASIA Motor, Functional and Health Related Quality of Life Outcome in Traumatic Central Cord Syndrome, a Prospective Randomized Study Unknown status NCT00475748 Phase 2
15 Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury Recruiting NCT04041063 Phase 2
16 Enabling Forelimb Function With Agonist Drug and Epidural Stimulation in SCI Active, not recruiting NCT02313194 Phase 1, Phase 2 Buspirone
17 Rehabilitation of the Lower Extremity With AMES Following Incomplete Spinal Cord Injury (SCI) Terminated NCT01498991 Phase 1, Phase 2
18 Effect of Two Different Air-stacking Techniques, Combined With Manually Assisted Cough, on Peak Cough Flow (PCF) in Patients With Acute Cervical or High Thoracic Spinal Cord Injury Withdrawn NCT01046175 Phase 2
19 Improving Ambulatory Community Access After Paralysis Unknown status NCT01570816 Phase 1
20 The Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Chronic Spinal Cord Injury (SCI) Receiving Rehabilitation Completed NCT02354625 Phase 1
21 Development and Translational Assessment of a Tongue-Based Assistive Neuro-Technology for Individuals With Severe Neurological Disorders Completed NCT01124292 Phase 1
22 The Role of Melatonin in the Regulation of Blood Coagulation Completed NCT01741389 Phase 1 Melatonin ("Circadin")
23 Use of Interactive Gaming After Spinal Cord Injury Completed NCT01537978 Phase 1
24 Brain Computer Interface Based Communication in the Completely Locked-In State Unknown status NCT02980380
25 Utrecht Neural Prosthesis (UNP): A Pilot Study on Controllability of Brain Signals and Application in locked-in Patients Unknown status NCT02224469
26 Clinical Evaluation of Brain-Computer Interface for Helping Communication of Quadriplegic Patients Unknown status NCT01707498
27 Development of a Spinal Cord Injury-specific Exercise-based Capacity Unknown status NCT02602639
28 Developing Strategies to Optimize the Exercise Response in Persons Living With Tetraplegia. Unknown status NCT04465825
29 Body Composition Assessment in Spinal Cord Injury Unknown status NCT00957762
30 Abdominal Functional Electrical Stimulation to Augment Breathing in Tetraplegia Unknown status NCT00202631
31 A Randomized, Crossover Clinical Trial of Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI Unknown status NCT02314221
32 Functional Electrical Stimulation Cycling in Acute Spinal Cord Injury; a Feasibility Study Unknown status NCT04064385
33 A Clinical Observational Follow-up Study of European Pediatric Cases of Acute Flaccid Myelitis Associated With EV-D68 Infection. Unknown status NCT03499366
34 Feasibility Study of the mindBEAGLE Device in Patients With Disorders of Consciousness or Locked-In Syndrome Completed NCT02772302
35 Mindfulness Meditation for Subjects With Severe Speech and Physical Impairments Completed NCT01964664
36 A Feasibility Study of the Ability of the Neural Prosthetic System to Provide Direct Brain Control of Extracorporeal Devices in Patients With Quadriplegia Due to High Spinal Cord Injury Completed NCT01849822
37 Reanimation in Tetraplegia: Restoring Cortical Control of Functional Movement in Humans With Quadriplegia Completed NCT01997125
38 Finding the Optimal Voluntary Exercise Parameters for Generating a Health Benefit in Those Living With Quadriplegia Completed NCT03146728
39 Intermittent Theta Burst Stimulation to Promote Motor Re-education After Upper Limb Reconstruction in Tetraplegia Completed NCT03277521
40 Cardiovascular Parameters for Lokomat Training in Chronic Incomplete SCI Completed NCT00385918
41 Study of the Surgical Treatment of Cervical Spinal Cord Injuries With Nerve Transfers to Restore Upper Extremity and Hand Function Completed NCT01899664
42 Functional Evaluation of the Recovery of Prehension in Quadriplegics by Implanted Neural Stimulation Completed NCT04306328
43 Effectiveness of Standing Frame on Constipation in Children With Cerebral Palsy: a Single Subject Study Completed NCT01911559
44 Exercise to Reduce Obesity in Spinal Cord Injury Completed NCT00270855
45 Prospective Comparative Multicenter Study on the Medico-economical Impact of the Brindley Technique in the Management of Neurogenic Bladder in Patients With Injured Spinal Cord Completed NCT00221767
46 Multi-Center Pivotal Study of NeuRx RA/4 Ventilatory Assist Device Completed NCT00010374
47 Electrical Stimulation in Denervated Muscles of the Upper Limbs - Effect on Muscle Morphological Properties - A Pilot Study Completed NCT03698136
48 Random Noise Stimulation to Enhance Corticomotor Drive for Improved Hand Function Completed NCT04777149
49 Conditioning Neural Circuits to Improve Upper Extremity Function Completed NCT02611375
50 Reach and Palmar Grasp in Tetraplegics With Neuromuscular Electrical Stimulation: Assessment and Training. Completed NCT02969772

Search NIH Clinical Center for Locked-in Syndrome

Cochrane evidence based reviews: locked-in syndrome

Genetic Tests for Locked-in Syndrome

Anatomical Context for Locked-in Syndrome

Organs/tissues related to Locked-in Syndrome:

MalaCards : Eye, Brain, Spinal Cord, Cortex, Tongue, Pons, Globus Pallidus

Publications for Locked-in Syndrome

Articles related to Locked-in Syndrome:

(show top 50) (show all 912)
# Title Authors PMID Year
1
Use of functional magnetic resonance imaging to assess cognition and consciousness in severe Guillain-Barré syndrome. 62
36415610 2023
2
Acute vertical pendular nystagmus: eye-movement analysis and review of the literature. 62
35904591 2022
3
Posttraumatic locked-in syndrome from combined brainstem and upper cervical injury in childhood: A case report. 62
35644290 2022
4
Writing Blindly in Incomplete Locked-In Syndrome with A Custom-Made Switch-Operated Voice-Scanning Communicator-A Case Report. 62
36358449 2022
5
Investigating Structure-Function Connectivity in a Patient With Locked-In Syndrome by 7 T Magnetic Resonance Imaging: A Case Report. 62
35238835 2022
6
Quality of life and mental health in the locked-in-state-differences between patients with amyotrophic lateral sclerosis and their next of kin. 62
35790562 2022
7
Methodological Recommendations for Studies on the Daily Life Implementation of Implantable Communication-Brain-Computer Interfaces for Individuals With Locked-in Syndrome. 62
36124975 2022
8
"Re-identifying yourself": a qualitative study of veteran views on implantable BCI for mobility and communication in ALS. 62
32940119 2022
9
A 44-Year-Old Alcohol-Dependent Man Who Recovered from Central Pontine Myelinolysis with Supportive Physical Therapy. 62
36081331 2022
10
Visuo-auditory stimuli with semantic, temporal and spatial congruence for a P300-based BCI: An exploratory test with an ALS patient in a completely locked-in state. 62
35817307 2022
11
[An autopsy case report of a patient with frontotemporal dementia with motor neuron disease in totally locked-in state showing hyperosmolar hyperosmotic state]. 62
35871561 2022
12
Development of Parkinsonism in a Patient with Central Pontine Myelinolysis. 62
36135990 2022
13
Locked-in syndrome responding to endovascular treatment. 62
35985839 2022
14
Towards predicting ECoG-BCI performance: assessing the potential of scalp-EEG. 62
35931055 2022
15
Thinking without speaking: Neuropsychological testing with individuals who have communication impairments. 62
33977850 2022
16
The locked-in syndrome: The early French descriptions. 62
35902307 2022
17
A man in a completely locked-in state produces intelligible sentences using a brain-computer interface. 62
35467033 2022
18
Optimizing Motor Imagery Parameters for Robotic Arm Control by Brain-Computer Interface. 62
35884640 2022
19
Mechanical thrombectomy via chronic occluded proximal artery for the endovascular treatment of acute ischemic stroke patients with large vessel occlusion. 62
35279585 2022
20
Locked-in Syndrome Due to Meningovascular Syphilis: A Case Report and Literature Review. 62
34670896 2022
21
Who gets to decide?: Substitute decision making following severe brain injury with communication impairment. 62
35373705 2022
22
An observational study on clinico aetiological profile and response to treatment and outcome of patients diagnosed with severe hyponatremia in medicine intensive care unit of a tertiary care centre. 62
35443480 2022
23
Brain implant enables man in locked-in state to communicate. 62
35324277 2022
24
Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training. 62
35318316 2022
25
A unique case of free-floating gastric band tubing causing intraabdominal sepsis in a patient with locked-in syndrome secondary to Guillain-Barré syndrome. 62
35350220 2022
26
French Survey on Pain Perception and Management in Patients with Locked-In Syndrome. 62
35328322 2022
27
The clinical and cognitive spectrum of locked-in syndrome: 1-year follow-up of 100 patients. 62
33987814 2022
28
Slow Firing Single Units Are Essential for Optimal Decoding of Silent Speech. 62
35992944 2022
29
Brain-Computer Interface: Applications to Speech Decoding and Synthesis to Augment Communication. 62
35099768 2022
30
Dramatic neuromuscular paralysis following occult snakebites: An awareness for the primary care physician. 62
35309641 2022
31
Clinical Validation of BCI-Controlled Wheelchairs in Subjects With Severe Spinal Cord Injury. 62
35259107 2022
32
Locked-In Syndrome: Practical Rehabilitation Management. 62
33465298 2021
33
Snakebite Mimicking Brain Death: Bedside Clues. 62
35027811 2021
34
Brain Computer Interfaces for Assisted Communication in Paralysis and Quality of Life. 62
34587854 2021
35
Magnetometers vs Gradiometers for Neural Speech Decoding. 62
34892608 2021
36
Decoding four hand gestures with a single bipolar pair of electrocorticography electrodes. 62
34607318 2021
37
Hyperhomocysteinemia induced locked-in syndrome in a young adult due to folic acid deficiency. 62
31642398 2021
38
Isolated basilar artery dissection following blunt trauma challenging the Glasgow coma score: A case report. 62
33745773 2021
39
Successful management of spinal cord ischemia in a pediatric patient with fibrocartilaginous embolism: illustrative case. 62
35855305 2021
40
Brain-Computer interfaces for communication: preferences of individuals with locked-in syndrome, caregivers and researchers. 62
34383613 2021
41
The influence of motivation and emotion on sensorimotor rhythm-based brain-computer interface performance. 62
33945156 2021
42
Locked-In Syndrome: A Systematic Review of Long-Term Management and Prognosis. 62
34471579 2021
43
EEG power spectral density in locked-in and completely locked-in state patients: a longitudinal study. 62
34035865 2021
44
Probable first report of a motor deafferentation syndrome in the Paraguayan War. 62
34190817 2021
45
Neurophysiological aspects of the completely locked-in syndrome in patients with advanced amyotrophic lateral sclerosis. 62
33743301 2021
46
Neuropsychological and neurophysiological aspects of brain-computer-interface (BCI) control in paralysis. 62
32045022 2021
47
Unusually prolonged neuromuscular weakness caused by krait (Bungarus caeruleus) bite: Two case reports. 62
33497743 2021
48
Classification of visual comprehension based on EEG data using sparse optimal scoring. 62
33440368 2021
49
Decoding overt shifts of attention in depth through pupillary and cortical frequency tagging. 62
32348980 2021
50
Brain-Computer Interfaces for Communication: Preferences of Individuals With Locked-in Syndrome. 62
33530868 2021

Variations for Locked-in Syndrome

Expression for Locked-in Syndrome

Search GEO for disease gene expression data for Locked-in Syndrome.

Pathways for Locked-in Syndrome

Pathways related to Locked-in Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.18 SOD1 ALS2

GO Terms for Locked-in Syndrome

Cellular components related to Locked-in Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular non-membrane-bounded organelle GO:0043232 9.26 TARDBP FUS
2 A band GO:0031672 8.8 LMOD3 KLHL40

Molecular functions related to Locked-in Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 molecular condensate scaffold activity GO:0140693 8.92 TARDBP FUS

Sources for Locked-in Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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