MCID: LCK001
MIFTS: 46

Locked-in Syndrome

Categories: Cardiovascular diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Locked-in Syndrome

MalaCards integrated aliases for Locked-in Syndrome:

Name: Locked-in Syndrome 12 74 52 53 58 15 71
Cerebromedullospinal Disconnection 52 58
Locked in Syndrome 12 52
Quadriplegia 43 71
Locked-in State 12

Characteristics:

Orphanet epidemiological data:

58
locked-in syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12697
ICD9CM 34 344.81
MeSH 43 D011782
SNOMED-CT 67 38023001
ICD10 32 G83.5
ICD10 via Orphanet 33 G83.8
UMLS via Orphanet 72 C0023944
Orphanet 58 ORPHA2406
UMLS 71 C0023944 C0034372

Summaries for Locked-in Syndrome

NIH Rare Diseases : 52 Locked-in syndrome is a rare neurological disorder characterized by complete paralysis of voluntary muscles, except for those that control the eyes. People with locked-in syndrome are conscious and can think and reason, but are unable to speak or move. Vertical eye movements and blinking can be used to communicate. Locked-in syndrome may be caused by brain stem stroke, traumatic brain injury, tumors , diseases of the circulatory system (bleeding), diseases that destroy the myelin sheath surrounding nerve cells (like multiple sclerosis), infection, or medication overdose. There is no cure or specific treatments for locked-in syndrome. Supportive therapy for breathing and feeding is very important, especially early on. Physical therapy , comfort care, nutritional support, and prevention of systemic complications such as respiratory infections are the mainstay of treatment. While partial recovery of muscle control is possible, it is somewhat dependent on the cause. Speech therapists can help people with locked-in syndrome communicate more clearly with eye movements and blinking. However, electronic communication devices, including patient-computer interfaces such as infrared eye movement sensors and computer voice prosthetics, are allowing people with locked-in syndrome to communicate more freely and have access to the internet. Motorized wheelchairs have also increased independence. Many people with locked-in syndrome do not live beyond the early (acute) stage due to medical complications. However, others may live for another 10-20 years and report a good quality of life despite the severe disabilities caused by the syndrome.

MalaCards based summary : Locked-in Syndrome, also known as cerebromedullospinal disconnection, is related to ichthyosis, spastic quadriplegia, and mental retardation and neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures, and has symptoms including muscle weakness, ophthalmoplegia and hemiplegia. An important gene associated with Locked-in Syndrome is ERI1 (Exoribonuclease 1). The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and eye, and related phenotypes are spasticity and diplopia

Disease Ontology : 12 A nervous system disease that is characterized by complete paralysis of all voluntary muscles except for the ones that control the movements of the eyes.

NINDS : 53 Locked-in syndrome is a rare neurological disorder characterized by complete paralysis of voluntary muscles in all parts of the body except for those that control eye movement. It may result from traumatic brain injury, diseases of the circulatory system, diseases that destroy the myelin sheath surrounding nerve cells, or medication overdose. Individuals with locked-in syndrome are conscious and can think and reason, but are unable to speak or move. The disorder leaves individuals completely mute and paralyzed. Communication may be possible with blinking eye movements

Wikipedia : 74 Locked-in syndrome (LIS), also known as pseudocoma, is a condition in which a patient is aware but... more...

Related Diseases for Locked-in Syndrome

Diseases related to Locked-in Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
# Related Disease Score Top Affiliating Genes
1 ichthyosis, spastic quadriplegia, and mental retardation 12.7
2 neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures 12.6
3 spastic quadriplegia, retinitis pigmentosa, and mental retardation 12.2
4 neurodevelopmental disorder with spastic quadriplegia, optic atrophy, seizures, and structural brain anomalies 12.2
5 microcephaly with spastic quadriplegia 12.2
6 absent eyebrows and eyelashes with mental retardation 11.7
7 central pontine myelinolysis 11.7
8 inherited congenital spastic tetraplegia 11.5
9 paraplegia 11.5
10 spastic cerebral palsy 11.4
11 epileptic encephalopathy, early infantile, 4 11.4
12 epileptic encephalopathy, early infantile, 5 11.4
13 pelizaeus-merzbacher disease 11.4
14 spastic tetraplegia, thin corpus callosum, and progressive microcephaly 11.3
15 alternating hemiplegia of childhood 1 11.2
16 alternating hemiplegia of childhood 2 11.2
17 epileptic encephalopathy, early infantile, 53 11.2
18 8p inverted duplication/deletion syndrome 11.2
19 extrapontine myelinolysis 11.2
20 diencephalic-mesencephalic junction dysplasia syndrome 1 11.2
21 spastic tetraplegia-retinitis pigmentosa-intellectual disability syndrome 11.2
22 congenital ichthyosis-microcephalus-tetraplegia syndrome 11.2
23 variegate porphyria 11.1
24 argininemia 11.1
25 farber lipogranulomatosis 11.1
26 mitochondrial complex ii deficiency 11.1
27 sulfite oxidase deficiency, isolated 11.1
28 allan-herndon-dudley syndrome 11.1
29 cerebral palsy, spastic quadriplegic, 2 11.1
30 asparagine synthetase deficiency 11.1
31 encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum 11.1
32 immunodeficiency 49 11.1
33 rab18 deficiency 11.1
34 encephalocele 11.1
35 familial glucocorticoid deficiency 11.1
36 spastic paraplegia 16 11.1
37 quadriplegia 10.7
38 ocular motor apraxia 10.5
39 mutism 10.5
40 hypokalemia 10.4
41 cerebral palsy 10.4
42 basilar artery occlusion 10.3
43 akinetic mutism 10.3
44 spinal stenosis 10.3
45 epidural abscess 10.3
46 ptosis 10.2
47 cranial nerve palsy 10.2
48 renal tubular acidosis 10.2
49 kearns-sayre syndrome 10.1
50 thrombosis 10.1

Graphical network of the top 20 diseases related to Locked-in Syndrome:



Diseases related to Locked-in Syndrome

Symptoms & Phenotypes for Locked-in Syndrome

Human phenotypes related to Locked-in Syndrome:

58 31 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 spasticity 58 31 hallmark (90%) Very frequent (99-80%) HP:0001257
2 diplopia 58 31 hallmark (90%) Very frequent (99-80%) HP:0000651
3 tetraplegia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002445
4 respiratory insufficiency 58 31 hallmark (90%) Very frequent (99-80%) HP:0002093
5 behavioral abnormality 58 31 hallmark (90%) Very frequent (99-80%) HP:0000708
6 abnormality of the voice 58 31 hallmark (90%) Very frequent (99-80%) HP:0001608
7 cerebral palsy 58 31 hallmark (90%) Very frequent (99-80%) HP:0100021
8 tetraparesis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002273
9 anarthria 58 31 hallmark (90%) Very frequent (99-80%) HP:0002425
10 recurrent respiratory infections 58 31 frequent (33%) Frequent (79-30%) HP:0002205
11 feeding difficulties 58 31 frequent (33%) Frequent (79-30%) HP:0011968
12 excessive salivation 58 31 frequent (33%) Frequent (79-30%) HP:0003781
13 hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000365
14 hypertonia 58 Very frequent (99-80%)
15 abnormality of the eye 58 Very frequent (99-80%)
16 abnormality of vision 58 Very frequent (99-80%)

UMLS symptoms related to Locked-in Syndrome:


muscle weakness, ophthalmoplegia, hemiplegia, quadriparesis, other quadriplegia

Drugs & Therapeutics for Locked-in Syndrome

Drugs for Locked-in Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
3
Midodrine Approved Phase 4 42794-76-3, 133163-28-7 4195
4
Baclofen Approved Phase 4 1134-47-0 2284
5
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
6 Antioxidants Phase 4
7 Protective Agents Phase 4
8 Omega 3 Fatty Acid Phase 4
9 Neurotransmitter Agents Phase 4
10 Autonomic Agents Phase 4
11 Anesthetics, General Phase 4
12 Sympathomimetics Phase 4
13 Adrenergic Agonists Phase 4
14 Vasoconstrictor Agents Phase 4
15 Adrenergic Agents Phase 4
16
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
17
Nitroarginine Experimental, Investigational Phase 2, Phase 3 2149-70-4
18 NG-Nitroarginine Methyl Ester Phase 2, Phase 3
19 Anti-Asthmatic Agents Phase 2, Phase 3
20 Free Radical Scavengers Phase 2, Phase 3
21 Vasodilator Agents Phase 2, Phase 3
22 Respiratory System Agents Phase 2, Phase 3
23 Bronchodilator Agents Phase 2, Phase 3
24
Arginine Investigational, Nutraceutical Phase 2, Phase 3 74-79-3 6322
25 Chlorhexidine gluconate Phase 1
26 Anesthetics Phase 1
27 Papaya Approved
28
mometasone furoate Approved, Investigational, Vet_approved 83919-23-7
29
Ipratropium Approved, Experimental 22254-24-6, 60205-81-4 43232 657309
30
Silicon Approved, Investigational 7440-21-3 4082203
31 Orange Approved
32 Kava Approved, Investigational, Nutraceutical 9000-38-8
33 insulin
34 Insulin, Globin Zinc
35 Cholinergic Agents
36 Cholinergic Antagonists
37 Vitamins
38 Whey Protein
39
s 1 (combination)
40 Central Nervous System Depressants

Interventional clinical trials:

(show top 50) (show all 138)
# Name Status NCT ID Phase Drugs
1 Phrenic Reinnervation in Central Ventilatory Paralysis Due to Medullary Trauma With Phrenic Motoneuron Destruction Completed NCT01350297 Phase 4
2 Melatonin Replacement for Treatment of Sleep Disruption Completed NCT00507546 Phase 4 Ramelteon;Placebo
3 Omega-3 Supplementation to Increase HDL-c Levels in Those With Tetraplegia Completed NCT01896037 Phase 4
4 Core Temperature During Cold Exposure in Persons With Tetraplegia Completed NCT01822535 Phase 4 Midodrine hydrochloride
5 Early Nerve Reconstruction Approach in Tetraplegic Patients With Dysfunctional Upper Extremity: a Randomized Controlled Trial. Recruiting NCT01579604 Phase 4
6 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Recruiting NCT02379156 Phase 4 Midodrine Hydrochloride
7 Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes? Terminated NCT00752934 Phase 4 oral baclofen + placebo;placebo + oral baclofen
8 Activity-Dependent Plasticity After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
9 Outcome Evaluation of Exercise and Electrical Therapy for Quadriplegic Hand Function Completed NCT00656149 Phase 2, Phase 3
10 Evaluation of the Efficacy of "MEOPA" Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. Completed NCT00632528 Phase 3 MEOPA;Medicinal air
11 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed NCT00237770 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
12 Improving Hand Function in Chronic SCI With Combined Robotic Training and tDCS Completed NCT03555838 Phase 3
13 The Effect of Nitric Oxide on Pulmonary Resistances and Blood Pressure in Persons With Tetraplegia Completed NCT00753948 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
14 Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network Completed NCT00614744 Phase 2, Phase 3
15 Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy Terminated NCT01192776 Phase 3
16 A Phase II/III, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Cethrin in Subjects With Acute Cervical Spinal Cord Injury Withdrawn NCT02053883 Phase 2, Phase 3 Cethrin (BA-210);Placebo
17 Randomised Open Study of the Efficiency and Tolerance of the Use of a Corset on the Respiratory Function of Spinal Cord Injury Patients Withdrawn NCT01569360 Phase 3
18 ASIA Motor, Functional and Health Related Quality of Life Outcome in Traumatic Central Cord Syndrome, a Prospective Randomized Study Unknown status NCT00475748 Phase 2
19 A Phase 1/2a Dose Escalation Study of AST-OPC1 in Subjects With Subacute Cervical Spinal Cord Injury Completed NCT02302157 Phase 1, Phase 2
20 FES Therapy:Restoring Voluntary Grasping Function in Chronic SCI Completed NCT01208688 Phase 2
21 Enabling Forelimb Function With Agonist Drug and Epidural Stimulation in SCI Recruiting NCT02313194 Phase 1, Phase 2
22 Neurodevice Phase II: Wireless Implantable Neurodevice Microsystem for Neuroprosthesis and Neuroscience Recruiting NCT03811301 Phase 2
23 Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury Recruiting NCT04041063 Phase 2
24 Rehabilitation of the Lower Extremity With AMES Following Incomplete Spinal Cord Injury (SCI) Terminated NCT01498991 Phase 1, Phase 2
25 Effect of Two Different Air-stacking Techniques, Combined With Manually Assisted Cough, on Peak Cough Flow (PCF) in Patients With Acute Cervical or High Thoracic Spinal Cord Injury Withdrawn NCT01046175 Phase 2
26 The Role of Melatonin in the Regulation of Blood Coagulation Completed NCT01741389 Phase 1 Melatonin ("Circadin")
27 The Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Chronic Spinal Cord Injury (SCI) Receiving Rehabilitation Completed NCT02354625 Phase 1
28 Development and Translational Assessment of a Tongue-Based Assistive Neuro-Technology for Individuals With Severe Neurological Disorders Completed NCT01124292 Phase 1
29 Use of Interactive Gaming After Spinal Cord Injury Completed NCT01537978 Phase 1
30 Improving Ambulatory Community Access After Paralysis Recruiting NCT01570816 Phase 1
31 Tissue Bonding Cystostomy(TBC) Not yet recruiting NCT01771159 Phase 1
32 Communication by Brain - Computer Interface in Amyotrophic Lateral Sclerosis:Feasibility Study Unknown status NCT01897818
33 Validating of Neurofeedback Practice by Utilizing TMS as an Assessment Tool Unknown status NCT01993316
34 Body Composition Assessment in Spinal Cord Injury Unknown status NCT00957762
35 Abdominal Functional Electrical Stimulation to Augment Breathing in Tetraplegia Unknown status NCT00202631
36 Investigating the Effect of Motor Imagery With or With no Visual Neurofeedback on Grasping Capabilities After C6-C7 Tetraplegia: a Multicentric Randomized Controlled Trial. Unknown status NCT03190863
37 Intra-operatory Neurophysiological Monitoring Changes as a Predictive Clinical Outcome Measure in Radiculopathy Associated to Lumbar Disk Disease. Two Years Follow-up Unknown status NCT02185508
38 Evaluation of Pediatric Critical Illness Neuropathy/Myopathy in Pediatric Intensive Care Unit Unknown status NCT02763709
39 Effects of the Prone and the Sitting Positions on the Brain Oxygenation in Posterior Fossa Surgery Unknown status NCT02933749
40 Multi-Center Pivotal Study of NeuRx RA/4 Ventilatory Assist Device Unknown status NCT00010374
41 A Randomized, Crossover Clinical Trial of Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI Unknown status NCT02314221
42 Evaluation of Evoked Potentials Recording Modalities in Healthy Volunteer Population. Completed NCT01518426 Early Phase 1
43 Mindfulness Meditation for Subjects With Severe Speech and Physical Impairments Completed NCT01964664
44 Effectiveness of Standing Frame on Constipation in Children With Cerebral Palsy: a Single Subject Study Completed NCT01911559
45 A Feasibility Study for Daily Use of a Brain Computer Interface for Communication in an ICU Completed NCT01005524
46 Influence of Upper Extremity Vibration on Spasticity and Function in Persons With Tetraplegia Completed NCT04020770
47 Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury (SCI) Completed NCT00833105
48 A Feasibility Study of the Ability of the Neural Prosthetic System to Provide Direct Brain Control of Extracorporeal Devices in Patients With Quadriplegia Due to High Spinal Cord Injury Completed NCT01849822
49 Correlation Between Wound Volume and Depth of Decubitus Ulcers And Resting Energy Expenditure Completed NCT01274650
50 Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia Completed NCT02860403

Search NIH Clinical Center for Locked-in Syndrome

Cochrane evidence based reviews: quadriplegia

Genetic Tests for Locked-in Syndrome

Anatomical Context for Locked-in Syndrome

MalaCards organs/tissues related to Locked-in Syndrome:

40
Spinal Cord, Brain, Eye, Bone, Heart, Liver, Testes

Publications for Locked-in Syndrome

Articles related to Locked-in Syndrome:

(show top 50) (show all 3350)
# Title Authors PMID Year
1
Locked-in syndrome in a patient with acute obstructive hydrocephalus, caused by large unruptured aneurysm of the basilar artery (BA). 61 52
27633006 2017
2
Recovery From Locked-in Syndrome. 61 52
26167898 2015
3
Transcranial direct current stimulation for a patient with locked-in syndrome. 61
31771814 2020
4
Phenotype-genotype correlations in patients with GNB1 gene variants, including the first three reported Japanese patients to exhibit spastic diplegia, dyskinetic quadriplegia, and infantile spasms. 61
31735425 2020
5
Early Gross Motor Development Among Brazilian Children with Microcephaly Born Right After Zika Virus Infection Outbreak. 61
31453893 2020
6
Neural Cell Adhesion Molecule (NCAM) a Serum Biomarker Indicative for the Severity of Cervical Spondylotic Myelopathy. 61
32039991 2020
7
Basilar artery thrombosis during sexual intercourse. 61
31982277 2020
8
Decreased mitochondrial DNA copy number in children with cerebral palsy quantified by droplet digital PCR. 61
31978410 2020
9
Spinal Epidural Hematoma Associated with Epidural Metastasis After Minor Trauma. 61
31568906 2020
10
Small interstitial 9p24.3 deletions principally involving KANK1 are likely benign copy number variants. 61
30684669 2020
11
Acute rhabdomyolysis following viral infection with coxsackie A4 in a 50-day-old infant with Fukuyama congenital muscular dystrophy. 61
31983616 2020
12
Early infantile-onset Leigh syndrome complicated with infantile spasms associated with the m.9185 T > C variant in the MT-ATP6 gene: Expanding the clinical spectrum. 61
31500933 2020
13
Toward Improving Diagnostic Strategies in Chronic Disorders of Consciousness: An Overview on the (Re-)Emergent Role of Neurophysiology. 61
31936844 2020
14
Mental imagery for brain-computer interface control and communication in non-responsive individuals. 61
30978530 2020
15
Acute fl accid quadriplegia: it is Hypokalemia or hyperkalemia..? 61
31979740 2020
16
Neurological recovery after surgical intervention of a complete spinal cord injury secondary to a chronic untreated odontoid neck fracture: a lesson in patient prognostication. 61
31937631 2020
17
Clinical significance of urinary obstruction in critically ill patients with urinary tract infections. 61
31895786 2020
18
Secondary hypokalemic paralysis with bulbar weakness and reversible electrophysiologic abnormalities: A case report and systematic review. 61
31439490 2019
19
A Case of Acute Intermittent Porphyria Mimicking Guillain-Barré Syndrome. 61
31903042 2019
20
A novel PAK3 pathogenic variant identified in two siblings from a Japanese family with X-linked intellectual disability: case report and review of the literature. 61
31444167 2019
21
Determining the Optimal Number of MEG Trials: A Machine Learning and Speech Decoding Perspective. 61
31768504 2019
22
[Locked-in Syndrome due to Primary Brainstem Injury:A Case Report]. 61
31874946 2019
23
[Comparison of multi-mode and single-mode intraoperative neurophysiological monitoring in the treatment of severe ossification of the cervical posterior longitudinal ligament with anterior cervical corpectomy with fusion]. 61
31870067 2019
24
DEGS1 variant causes neurological disorder. 61
31186544 2019
25
Longitudinal MRI findings in patient with SLC25A12 pathogenic variants inform disease progression and classification. 61
31403263 2019
26
Cocaine as a rare cause of locked-in syndrome: a case report. 61
31739807 2019
27
Severe Neuromuscular Scoliosis Implicated by Dysfunction of Intrathecal Baclofen Pump: Case Report and Review of the Literature. 61
31733394 2019
28
Strabismus Is Correlated with Gross Motor Function in Children with Spastic Cerebral Palsy. 61
31189336 2019
29
Ethics of life-sustaining treatment in locked-in syndrome: A Chinese survey. 61
31682940 2019
30
God locked you in the room, but left a window open: A case report of spinal cord stimulation in locked-in syndrome. 61
31434619 2019
31
Burn on the buttocks caused by gel wheelchair cushion left on driver's seat of hand control car. 61
30946002 2019
32
Neuroprosthetic Speech: The Ethical Significance of Accuracy, Control and Pragmatics. 61
31475659 2019
33
The effect of arm-crank exercise training on power output, spirometric and cardiac function and level of autonomy in persons with tetraplegia. 61
31566476 2019
34
Psychological morbidity and chronic disease among adults with nontraumatic spinal cord injuries: a cohort study of privately insured beneficiaries. 61
31153961 2019
35
Hyperhomocysteinemia induced locked-in syndrome in a young adult due to folic acid deficiency. 61
31642398 2019
36
Ultrasonographic findings of shoulders in individuals with spinal cord injury. 61
31603385 2019
37
Longitudinally extensive transverse myelitis with seropositive chikungunya. 61
31604723 2019
38
Single-paradigm and hybrid brain computing interfaces and their use by disabled patients. 61
31163412 2019
39
Use of outcome measures in children with severe cerebral palsy: A survey of U.K. physiotherapists. 61
31172663 2019
40
Traumatic posterior atlantooccipital dislocation combined with type II dens fracture and C1 anterior arch fracture: Two case reports. 61
31651894 2019
41
[Varicella-zoster virus-associated polyradiculoneuritis with concomitant herpes zoster eruption: a case report]. 61
31564701 2019
42
Nutritional status of children with cerebral palsy in remote Sumba Island of Indonesia: a community-based key informants study. 61
31656105 2019
43
Progressive Paraplegia Due to Spinal Dural Arteriovenous Fistula: A Rare but Treatable Diagnosis That Should Not Be Missed. 61
31772863 2019
44
Predictors of Hospital-Acquired Conditions Are Predominately Similar for Spine Surgery and Other Common Elective Surgical Procedures, With Some Key Exceptions. 61
31552152 2019
45
Etiological Spectrum of Non-compressive Myelopathies in Tertiary Care Centre. 61
31561681 2019
46
The Clinical Implications and Complications of Anterior Versus Posterior Surgery for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament; An Updated Systematic Review and Meta-Analysis. 61
31607084 2019
47
Long-term prognosis of epilepsy in patients with cerebral palsy. 61
30854645 2019
48
Anti-pan-neurofascin IgG3 as a marker of fulminant autoimmune neuropathy. 61
31454780 2019
49
Effect of intravenous immunoglobulin therapy on anti-NT5C1A antibody-positive inclusion body myositis after successful treatment of hepatitis C: A case report. 61
31517073 2019
50
Late recovery of responsiveness after intra-thecal baclofen pump implantation and the role of diffuse pain and severe spasticity: a case report. 61
31267188 2019

Variations for Locked-in Syndrome

Expression for Locked-in Syndrome

Search GEO for disease gene expression data for Locked-in Syndrome.

Pathways for Locked-in Syndrome

GO Terms for Locked-in Syndrome

Sources for Locked-in Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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